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Tytuł:
Adaptation of a transmitted/founder simian-human immunodeficiency virus for enhanced replication in rhesus macaques.
Autorzy:
Bauer A; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Lindemuth E; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Marino FE; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Krause R; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Joy J; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Docken SS; Kirby Institute, University of New South Wales, Sydney, Australia.
Mallick S; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
McCormick K; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Holt C; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee, United States of America.
Georgiev I; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee, United States of America.
Felber B; Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, Maryland, United States of America.
Keele BF; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.
Veazey R; Department of Pathology and Laboratory Medicine, Tulane School of Medicine, New Orleans, Louisiana, United States of America.
Davenport MP; Kirby Institute, University of New South Wales, Sydney, Australia.
Li H; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Departments of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Shaw GM; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Departments of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Bar KJ; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2023 Jul 03; Vol. 19 (7), pp. e1011059. Date of Electronic Publication: 2023 Jul 03 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Simian Acquired Immunodeficiency Syndrome*
Simian Immunodeficiency Virus*
HIV Infections*
HIV-1*
HIV Seropositivity*
Animals ; Humans ; Macaca mulatta/metabolism ; env Gene Products, Human Immunodeficiency Virus ; Virus Replication/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates.
Autorzy:
van Schooten J; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, location AMC, University of Amsterdam, Amsterdam, The Netherlands.
van Haaren MM; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, location AMC, University of Amsterdam, Amsterdam, The Netherlands.
Li H; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
McCoy LE; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.; Division of Infection and Immunity, University College London, London, United Kingdom.
Havenar-Daughton C; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America.
Cottrell CA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Burger JA; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, location AMC, University of Amsterdam, Amsterdam, The Netherlands.
van der Woude P; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, location AMC, University of Amsterdam, Amsterdam, The Netherlands.
Helgers LC; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, location AMC, University of Amsterdam, Amsterdam, The Netherlands.
Tomris I; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, location AMC, University of Amsterdam, Amsterdam, The Netherlands.
Labranche CC; Laboratory for AIDS Vaccine Research and Development, Duke University Medical Center, Durham, North Carolina, United States of America.
Montefiori DC; Laboratory for AIDS Vaccine Research and Development, Duke University Medical Center, Durham, North Carolina, United States of America.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.; International AIDS Vaccine Initiative-Neutralizing Antibody Center (IAVI-NAC), The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America.
Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.; International AIDS Vaccine Initiative-Neutralizing Antibody Center (IAVI-NAC), The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America.; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
Moore JP; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America.
Sanders RW; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, location AMC, University of Amsterdam, Amsterdam, The Netherlands.; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America.
Crotty S; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America.
Shaw GM; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
van Gils MJ; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, location AMC, University of Amsterdam, Amsterdam, The Netherlands.
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Źródło:
PLoS pathogens [PLoS Pathog] 2021 Aug 25; Vol. 17 (8), pp. e1009736. Date of Electronic Publication: 2021 Aug 25 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
AIDS Vaccines/*administration & dosage
Antibodies, Neutralizing/*immunology
Epitopes/*immunology
HIV Infections/*immunology
HIV-1/*immunology
Simian Acquired Immunodeficiency Syndrome/*immunology
env Gene Products, Human Immunodeficiency Virus/*immunology
AIDS Vaccines/immunology ; Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/immunology ; Antibody Formation ; Antigens, Viral/immunology ; HIV Antibodies/immunology ; HIV Infections/virology ; Humans ; Immunization ; Infant ; Kenya ; Primates ; Protein Multimerization ; Simian Acquired Immunodeficiency Syndrome/prevention & control ; Simian Immunodeficiency Virus/immunology ; Vaccination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection.
Autorzy:
Charles TP; Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Burton SL; Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Arunachalam PS; Departments of Pathology, and Microbiology and Immunology, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, California, United States of America.
Cottrell CA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Sewall LM; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Bollimpelli VS; Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Gangadhara S; Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Dey AK; International AIDS Vaccine Initiative, New York, New York, United States of America.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Shaw GM; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Hunter E; Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.
Amara RR; Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, United States of America.
Pulendran B; Departments of Pathology, and Microbiology and Immunology, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, California, United States of America.
van Gils MJ; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Derdeyn CA; Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2021 Feb 08; Vol. 17 (2), pp. e1009257. Date of Electronic Publication: 2021 Feb 08 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies, Neutralizing/*immunology
HIV Antibodies/*immunology
HIV-1/*immunology
Polysaccharides/*immunology
Simian Acquired Immunodeficiency Syndrome/*prevention & control
Simian Immunodeficiency Virus/*immunology
env Gene Products, Human Immunodeficiency Virus/*immunology
Animals ; Epitopes/immunology ; Female ; HIV Infections/immunology ; HIV Infections/virology ; Humans ; Immunization ; Macaca mulatta ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Acquired Immunodeficiency Syndrome/virology ; Vaccination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.
Autorzy:
Roark RS; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Li H; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Williams WB; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Chug H; Laboratory of Molecular Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Mason RD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Gorman J; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Wang S; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lee FH; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Rando J; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bonsignori M; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Hwang KK; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.
Saunders KO; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.; Departments of Immunology and Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Wiehe K; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Moody MA; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.; Departments of Pediatrics and Immunology, Duke University School of Medicine, Durham, NC 27710, USA.
Hraber PT; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Wagh K; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Giorgi EE; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Russell RM; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bibollet-Ruche F; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Liu W; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Connell J; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Smith AG; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
DeVoto J; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Murphy AI; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Smith J; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ding W; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Zhao C; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Chohan N; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Okumura M; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Rosario C; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ding Y; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lindemuth E; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bauer AM; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bar KJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ambrozak D; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Chao CW; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Chuang GY; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Geng H; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Lin BC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Louder MK; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Nguyen R; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Zhang B; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Lewis MG; Bioqual, Inc., Rockville, MD 20850, USA.
Raymond DD; Laboratory of Molecular Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Doria-Rose NA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Schramm CA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Douek DC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Kepler TB; Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.; Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA.
Kelsoe G; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.; Departments of Immunology and Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Mascola JR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Kwong PD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Korber BT; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Harrison SC; Laboratory of Molecular Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Haynes BF; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Hahn BH; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Shaw GM; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. .
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Źródło:
Science (New York, N.Y.) [Science] 2021 Jan 08; Vol. 371 (6525). Date of Electronic Publication: 2020 Nov 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms:
Broadly Neutralizing Antibodies*/chemistry
Broadly Neutralizing Antibodies*/genetics
Broadly Neutralizing Antibodies*/immunology
HIV Antibodies*/chemistry
HIV Antibodies*/genetics
HIV Antibodies*/immunology
Biological Coevolution/*immunology
HIV Envelope Protein gp120/*immunology
HIV Infections/*immunology
HIV-1/*immunology
Simian Immunodeficiency Virus/*immunology
Animals ; Binding Sites ; CD4 Antigens/immunology ; Cryoelectron Microscopy ; Epitopes/immunology ; HIV Envelope Protein gp120/genetics ; HIV-1/genetics ; Humans ; Macaca mulatta ; Molecular Mimicry/immunology ; Simian Immunodeficiency Virus/genetics ; Virus Replication
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes.
Autorzy:
O'Brien SP; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States of America.
Swanstrom AE; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States of America.
Pegu A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
Ko SY; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
Immonen TT; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States of America.
Del Prete GQ; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States of America.
Fennessey CM; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States of America.
Gorman J; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
Foulds KE; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
Schmidt SD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
Doria-Rose N; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
Williamson C; Division of Medical Virology, University of Cape Town, Cape Town, South Africa.; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban, South Africa.
Hatziioannou T; The Rockefeller University, New York, NY, United States of America.
Bieniasz PD; The Rockefeller University, New York, NY, United States of America.; Howard Hughes Medical Institute, The Rockefeller University, New York, NY, United States of America.
Li H; Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Shaw GM; Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Mascola JR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
Koup RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
Kwong PD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
Lifson JD; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States of America.
Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
Keele BF; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2019 Apr 03; Vol. 15 (4), pp. e1007632. Date of Electronic Publication: 2019 Apr 03 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Mutation*
HIV Infections/*virology
HIV-1/*genetics
Simian Acquired Immunodeficiency Syndrome/*virology
Simian Immunodeficiency Virus/*genetics
env Gene Products, Human Immunodeficiency Virus/*metabolism
Animals ; Gene Expression Regulation, Viral ; Humans ; Macaca mulatta ; Research Design ; Virus Replication ; env Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection.
Autorzy:
Kijak GH; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Sanders-Buell E; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Chenine AL; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Eller MA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Goonetilleke N; School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Thomas R; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Leviyang S; Department of Mathematics and Statistics, Georgetown University, Washington, DC, United States of America.
Harbolick EA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Bose M; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Pham P; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Oropeza C; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Poltavee K; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
O'Sullivan AM; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Billings E; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Merbah M; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Costanzo MC; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Warren JA; School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Slike B; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Li H; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Peachman KK; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Fischer W; Theoretical Biology, Los Alamos National Laboratory, Los Alamos, NM, United States of America.
Gao F; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America.
Cicala C; Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
Arthos J; Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
Eller LA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
O'Connell RJ; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Sinei S; Walter Reed Project, Kericho, Kenya.
Maganga L; Mbeya Medical Research Programme, Mbeya, Tanzania.
Kibuuka H; Makerere University-Walter Reed Project, Kampala, Uganda.
Nitayaphan S; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Rao M; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.
Marovich MA; Vaccine Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States of America.
Krebs SJ; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Rolland M; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Korber BT; Theoretical Biology, Los Alamos National Laboratory, Los Alamos, NM, United States of America.
Shaw GM; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Michael NL; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.
Robb ML; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Tovanabutra S; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Kim JH; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.
Pokaż więcej
Źródło:
PLoS pathogens [PLoS Pathog] 2017 Jul 31; Vol. 13 (7), pp. e1006510. Date of Electronic Publication: 2017 Jul 31 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
HIV Infections/*virology
HIV-1/*genetics
HIV-1/*isolation & purification
Adolescent ; Adult ; Cohort Studies ; Female ; HIV Infections/immunology ; HIV Infections/transmission ; HIV-1/classification ; HIV-1/physiology ; High-Throughput Nucleotide Sequencing ; Humans ; Immune Evasion ; Male ; Middle Aged ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/virology ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Transmitted virus fitness and host T cell responses collectively define divergent infection outcomes in two HIV-1 recipients.
Autorzy:
Yue L; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Pfafferott KJ; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Baalwa J; Department of Medicine, University of Alabama, Birmingham, Alabama, United States of America.
Conrod K; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Dong CC; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Chui C; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Rong R; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Claiborne DT; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Prince JL; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Tang J; Department of Medicine, University of Alabama, Birmingham, Alabama, United States of America.
Ribeiro RM; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
Cormier E; Human Immunology Laboratory, International AIDS Vaccine Initiative, London, United Kingdom.
Hahn BH; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
Shaw GM; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Karita E; Rwanda-Zambia HIV Research Project, Project San Francisco, Kigali, Rwanda.
Gilmour J; Human Immunology Laboratory, International AIDS Vaccine Initiative, London, United Kingdom.
Goepfert P; Department of Medicine, University of Alabama, Birmingham, Alabama, United States of America.
Derdeyn CA; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.
Allen SA; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.
Borrow P; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Hunter E; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.
Pokaż więcej
Źródło:
PLoS pathogens [PLoS Pathog] 2015 Jan 08; Vol. 11 (1), pp. e1004565. Date of Electronic Publication: 2015 Jan 08 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Genetic Fitness*
HIV Infections/*diagnosis
HIV-1/*genetics
HIV-1/*immunology
Host-Pathogen Interactions/*immunology
T-Lymphocytes/*immunology
Adult ; Amino Acid Sequence ; Epitopes, T-Lymphocyte/genetics ; Epitopes, T-Lymphocyte/immunology ; Evolution, Molecular ; Female ; HEK293 Cells ; HIV Infections/genetics ; HIV Infections/immunology ; HIV Infections/transmission ; Host-Pathogen Interactions/genetics ; Humans ; Immune Evasion/genetics ; Male ; Molecular Sequence Data ; Phylogeny ; Prognosis ; Viral Load/genetics ; Virus Replication/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Relative resistance of HIV-1 founder viruses to control by interferon-alpha.
Autorzy:
Fenton-May AE; Nuffield Department of Medicine, University of Oxford, NDM Research Building, Old Road Campus, Headington, Oxford OX3 7FZ, UK. .
Dibben O
Emmerich T
Ding H
Pfafferott K
Aasa-Chapman MM
Pellegrino P
Williams I
Cohen MS
Gao F
Shaw GM
Hahn BH
Ochsenbauer C
Kappes JC
Borrow P
Pokaż więcej
Źródło:
Retrovirology [Retrovirology] 2013 Dec 03; Vol. 10, pp. 146. Date of Electronic Publication: 2013 Dec 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Resistance, Viral*
HIV Infections/*virology
HIV-1/*drug effects
HIV-1/*immunology
Interferon-alpha/*immunology
Interferon-alpha/*pharmacology
Virus Replication/*drug effects
HIV Infections/immunology ; HIV-1/isolation & purification ; Humans ; Inhibitory Concentration 50 ; Microbial Sensitivity Tests
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Clonal amplification and maternal-infant transmission of nevirapine-resistant HIV-1 variants in breast milk following single-dose nevirapine prophylaxis.
Autorzy:
Permar SR; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA.
Salazar MG
Gao F
Cai F
Learn GH
Kalilani L
Hahn BH
Shaw GM
Salazar-Gonzalez JF
Pokaż więcej
Źródło:
Retrovirology [Retrovirology] 2013 Aug 14; Vol. 10, pp. 88. Date of Electronic Publication: 2013 Aug 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Resistance, Viral*
Anti-HIV Agents/*administration & dosage
HIV Infections/*prevention & control
HIV Infections/*virology
HIV-1/*drug effects
Milk, Human/*virology
Nevirapine/*administration & dosage
Anti-HIV Agents/pharmacology ; Chemoprevention/methods ; Cluster Analysis ; Female ; Genotype ; HIV Infections/transmission ; HIV-1/classification ; HIV-1/genetics ; HIV-1/isolation & purification ; Humans ; Infant ; Infant, Newborn ; Infectious Disease Transmission, Vertical/prevention & control ; Molecular Epidemiology ; Molecular Sequence Data ; Nevirapine/pharmacology ; Phylogeny ; Pregnancy ; RNA, Viral/genetics ; Sequence Analysis, DNA ; Sequence Homology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.
Autorzy:
Liao HX; Duke University Human Vaccine Institute, Departments of Medicine and Immunology, Duke University School of Medicine, Durham, North Carolina 27710, USA. />Lynch R
Zhou T
Gao F
Alam SM
Boyd SD
Fire AZ
Roskin KM
Schramm CA
Zhang Z
Zhu J
Shapiro L
Mullikin JC
Gnanakaran S
Hraber P
Wiehe K
Kelsoe G
Yang G
Xia SM
Montefiori DC
Parks R
Lloyd KE
Scearce RM
Soderberg KA
Cohen M
Kamanga G
Louder MK
Tran LM
Chen Y
Cai F
Chen S
Moquin S
Du X
Joyce MG
Srivatsan S
Zhang B
Zheng A
Shaw GM
Hahn BH
Kepler TB
Korber BT
Kwong PD
Mascola JR
Haynes BF
Pokaż więcej
Corporate Authors:
NISC Comparative Sequencing Program
Źródło:
Nature [Nature] 2013 Apr 25; Vol. 496 (7446), pp. 469-76. Date of Electronic Publication: 2013 Apr 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Evolution, Molecular*
Antibodies, Neutralizing/*chemistry
Antibodies, Neutralizing/*immunology
HIV Antibodies/*chemistry
HIV Antibodies/*immunology
HIV-1/*chemistry
HIV-1/*immunology
AIDS Vaccines/immunology ; Africa ; Amino Acid Sequence ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/immunology ; Antibodies, Neutralizing/genetics ; CD4 Antigens/chemistry ; CD4 Antigens/immunology ; Cell Lineage ; Cells, Cultured ; Clone Cells/cytology ; Cross Reactions/immunology ; Crystallography, X-Ray ; Epitopes/chemistry ; Epitopes/immunology ; HIV Antibodies/genetics ; HIV Envelope Protein gp120/chemistry ; HIV Envelope Protein gp120/genetics ; HIV Envelope Protein gp120/immunology ; HIV Envelope Protein gp120/metabolism ; HIV-1/classification ; Humans ; Models, Molecular ; Molecular Sequence Data ; Mutation ; Neutralization Tests ; Phylogeny ; Protein Structure, Tertiary
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants.
Autorzy:
Fouda GG; Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA.
Mahlokozera T
Salazar-Gonzalez JF
Salazar MG
Learn G
Kumar SB
Dennison SM
Russell E
Rizzolo K
Jaeger F
Cai F
Vandergrift NA
Gao F
Hahn B
Shaw GM
Ochsenbauer C
Swanstrom R
Meshnick S
Mwapasa V
Kalilani L
Fiscus S
Montefiori D
Haynes B
Kwiek J
Alam SM
Permar SR
Pokaż więcej
Źródło:
Retrovirology [Retrovirology] 2013 Jan 10; Vol. 10, pp. 3. Date of Electronic Publication: 2013 Jan 10.
Typ publikacji:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Infectious Disease Transmission, Vertical*
Gastrointestinal Tract/*virology
HIV Infections/*transmission
HIV-1/*genetics
Milk, Human/*immunology
env Gene Products, Human Immunodeficiency Virus/*genetics
Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/metabolism ; Breast Feeding ; Cohort Studies ; Female ; Gastrointestinal Tract/immunology ; HIV Antibodies/blood ; HIV Antibodies/metabolism ; HIV Infections/immunology ; HIV-1/pathogenicity ; Humans ; Infant ; Milk, Human/virology ; Neutralization Tests ; Phylogeny ; Sequence Analysis, RNA ; Viral Load
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape.
Autorzy:
Bar KJ; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Tsao CY
Iyer SS
Decker JM
Yang Y
Bonsignori M
Chen X
Hwang KK
Montefiori DC
Liao HX
Hraber P
Fischer W
Li H
Wang S
Sterrett S
Keele BF
Ganusov VV
Perelson AS
Korber BT
Georgiev I
McLellan JS
Pavlicek JW
Gao F
Haynes BF
Hahn BH
Kwong PD
Shaw GM
Pokaż więcej
Źródło:
PLoS pathogens [PLoS Pathog] 2012; Vol. 8 (5), pp. e1002721. Date of Electronic Publication: 2012 May 31.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Antibodies, Neutralizing/*pharmacology
HIV Antibodies/*pharmacology
HIV Infections/*drug therapy
HIV-1/*drug effects
Immune Evasion/*drug effects
Virus Replication/*drug effects
AIDS Vaccines/immunology ; Adaptive Immunity ; Antibodies, Neutralizing/immunology ; Dose-Response Relationship, Immunologic ; Genes, Viral ; Genome ; HIV Antibodies/immunology ; HIV Envelope Protein gp120/drug effects ; HIV Envelope Protein gp120/immunology ; HIV Infections/immunology ; HIV-1/genetics ; Host-Pathogen Interactions ; Immune Evasion/immunology ; Neutralization Tests
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7.
Autorzy:
Parrish NF; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Wilen CB
Banks LB
Iyer SS
Pfaff JM
Salazar-Gonzalez JF
Salazar MG
Decker JM
Parrish EH
Berg A
Hopper J
Hora B
Kumar A
Mahlokozera T
Yuan S
Coleman C
Vermeulen M
Ding H
Ochsenbauer C
Tilton JC
Permar SR
Kappes JC
Betts MR
Busch MP
Gao F
Montefiori D
Haynes BF
Shaw GM
Hahn BH
Doms RW
Pokaż więcej
Źródło:
PLoS pathogens [PLoS Pathog] 2012; Vol. 8 (5), pp. e1002686. Date of Electronic Publication: 2012 May 31.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
CD4 Antigens/*metabolism
HIV Infections/*transmission
HIV-1/*pathogenicity
Integrins/*metabolism
Receptors, CCR5/*metabolism
Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/virology ; Cells, Cultured ; Cloning, Molecular ; HIV Envelope Protein gp120/chemistry ; HIV Envelope Protein gp120/immunology ; HIV Envelope Protein gp120/metabolism ; HIV Infections/metabolism ; HIV-1/immunology ; HIV-1/metabolism ; Host-Pathogen Interactions ; Humans ; Integrins/immunology ; Mucous Membrane/virology ; Neutralization Tests ; Viral Tropism ; Virus Internalization ; Virus Replication
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections.
Autorzy:
Gnanakaran S; Theoretical Biology, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
Bhattacharya T
Daniels M
Keele BF
Hraber PT
Lapedes AS
Shen T
Gaschen B
Krishnamoorthy M
Li H
Decker JM
Salazar-Gonzalez JF
Wang S
Jiang C
Gao F
Swanstrom R
Anderson JA
Ping LH
Cohen MS
Markowitz M
Goepfert PA
Saag MS
Eron JJ
Hicks CB
Blattner WA
Tomaras GD
Asmal M
Letvin NL
Gilbert PB
Decamp AC
Magaret CA
Schief WR
Ban YE
Zhang M
Soderberg KA
Sodroski JG
Haynes BF
Shaw GM
Hahn BH
Korber B
Pokaż więcej
Źródło:
PLoS pathogens [PLoS Pathog] 2011 Sep; Vol. 7 (9), pp. e1002209. Date of Electronic Publication: 2011 Sep 29.
Typ publikacji:
Clinical Trial; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
MeSH Terms:
Mutation, Missense*
HIV Infections/*genetics
HIV-1/*genetics
Protein Sorting Signals/*genetics
env Gene Products, Human Immunodeficiency Virus/*genetics
Adaptive Immunity ; Amino Acid Motifs ; Amino Acid Substitution ; Antibodies, Viral/immunology ; Binding Sites/genetics ; CD4 Antigens/genetics ; CD4 Antigens/immunology ; Chronic Disease ; Gene Expression Regulation, Viral/physiology ; Glycosylation ; HIV Infections/immunology ; HIV-1/immunology ; HIV-1/pathogenicity ; Receptors, CCR5/genetics ; Receptors, CCR5/immunology ; Retrospective Studies ; env Gene Products, Human Immunodeficiency Virus/biosynthesis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Escape is a more common mechanism than avidity reduction for evasion of CD8+ T cell responses in primary human immunodeficiency virus type 1 infection.
Autorzy:
Turnbull EL; Nuffield Department of Clinical Medicine, University of Oxford, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK. .
Baalwa J
Conrod KE
Wang S
Wei X
Wong M
Turner J
Pellegrino P
Williams I
Shaw GM
Borrow P
Pokaż więcej
Źródło:
Retrovirology [Retrovirology] 2011 Jun 02; Vol. 8, pp. 41. Date of Electronic Publication: 2011 Jun 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Immune Evasion*
Mutation, Missense*
CD8-Positive T-Lymphocytes/*immunology
HIV Infections/*immunology
HIV Infections/*virology
HIV-1/*immunology
Viral Proteins/*immunology
Epitopes, T-Lymphocyte/genetics ; Epitopes, T-Lymphocyte/immunology ; Humans ; Viral Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A signature in HIV-1 envelope leader peptide associated with transition from acute to chronic infection impacts envelope processing and infectivity.
Autorzy:
Asmal M; Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America. />Hellmann I
Liu W
Keele BF
Perelson AS
Bhattacharya T
Gnanakaran S
Daniels M
Haynes BF
Korber BT
Hahn BH
Shaw GM
Letvin NL
Pokaż więcej
Źródło:
PloS one [PLoS One] 2011; Vol. 6 (8), pp. e23673. Date of Electronic Publication: 2011 Aug 18.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Disease Progression*
Protein Sorting Signals*
Gene Products, env/*metabolism
HIV Infections/*pathology
HIV Infections/*virology
HIV-1/*metabolism
HIV-1/*pathogenicity
Acute Disease ; Amino Acid Sequence ; Chronic Disease ; Endoplasmic Reticulum/metabolism ; Gene Products, env/chemistry ; HIV Core Protein p24/metabolism ; Humans ; Jurkat Cells ; Likelihood Functions ; Models, Biological ; Molecular Sequence Data ; Phylogeny ; Polymorphism, Genetic ; Protein Structure, Tertiary ; Protein Transport ; Virion/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Genetic signatures in the envelope glycoproteins of HIV-1 that associate with broadly neutralizing antibodies.
Autorzy:
Gnanakaran S; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
Daniels MG
Bhattacharya T
Lapedes AS
Sethi A
Li M
Tang H
Greene K
Gao H
Haynes BF
Cohen MS
Shaw GM
Seaman MS
Kumar A
Gao F
Montefiori DC
Korber B
Pokaż więcej
Źródło:
PLoS computational biology [PLoS Comput Biol] 2010 Oct 07; Vol. 6 (10), pp. e1000955. Date of Electronic Publication: 2010 Oct 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies, Neutralizing/*metabolism
Computational Biology/*methods
HIV Envelope Protein gp120/*genetics
HIV Envelope Protein gp41/*genetics
HIV-1/*genetics
Algorithms ; Amino Acid Sequence ; Antibodies, Neutralizing/blood ; Artificial Intelligence ; Cluster Analysis ; DNA Mutational Analysis/methods ; Epitope Mapping ; Epitopes, T-Lymphocyte ; HIV Envelope Protein gp120/metabolism ; HIV Envelope Protein gp41/metabolism ; Humans ; Logistic Models ; Models, Molecular ; Mutation/genetics ; Neutralization Tests ; Phylogeny ; Sequence Alignment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing.
Autorzy:
Fischer W; Theoretical Biology, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
Ganusov VV
Giorgi EE
Hraber PT
Keele BF
Leitner T
Han CS
Gleasner CD
Green L
Lo CC
Nag A
Wallstrom TC
Wang S
McMichael AJ
Haynes BF
Hahn BH
Perelson AS
Borrow P
Shaw GM
Bhattacharya T
Korber BT
Pokaż więcej
Źródło:
PloS one [PLoS One] 2010 Aug 20; Vol. 5 (8), pp. e12303. Date of Electronic Publication: 2010 Aug 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Evolution, Molecular*
Sequence Analysis, DNA*
Genome, Viral/*genetics
HIV-1/*genetics
HIV-1/*physiology
Immune Evasion/*genetics
Consensus Sequence ; Epitopes/genetics ; Epitopes/immunology ; HIV Infections/immunology ; HIV-1/immunology ; Humans ; Mutation ; Selection, Genetic ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI.
Autorzy:
Kim KA; Institute of Molecular Virology, University Hospital Ulm, 89081 Ulm, Germany.
Yolamanova M
Zirafi O
Roan NR
Staendker L
Forssmann WG
Burgener A
Dejucq-Rainsford N
Hahn BH
Shaw GM
Greene WC
Kirchhoff F
Münch J
Pokaż więcej
Źródło:
Retrovirology [Retrovirology] 2010 Jun 23; Vol. 7, pp. 55. Date of Electronic Publication: 2010 Jun 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Sexually Transmitted Diseases, Viral*
Virus Attachment*
Amyloid/*metabolism
HIV Infections/*transmission
HIV-1/*pathogenicity
Protein Tyrosine Phosphatases/*metabolism
Semen/*virology
Acid Phosphatase ; Animals ; Cell Line ; HIV-2/pathogenicity ; Humans ; Hydrogen-Ion Concentration ; Primates ; Protein Binding ; Simian Immunodeficiency Virus/pathogenicity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 37

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