Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure.
Autorzy :
Bertrand JA; Dept. of Bioengineering, Imperial College London, Prince Consort Road, South Kensington, London, SW7 2AZ, United Kingdom. Woodward DF; Dept. of Bioengineering, Imperial College London, Prince Consort Road, South Kensington, London, SW7 2AZ, United Kingdom; JeniVision Inc., 5270, California Ave., Irvine, CA 92617, United States. Electronic address: . SherwoodJM; Dept. of Bioengineering, Imperial College London, Prince Consort Road, South Kensington, London, SW7 2AZ, United Kingdom. Spenlehauer A; Dept. of Bioengineering, Imperial College London, Prince Consort Road, South Kensington, London, SW7 2AZ, United Kingdom. Silvestri C; Département de Médecine, Université Laval, 1050 Avenue de la Médecine, Québec, QC, Canada, G1V 0A6; Institut universitaire de cardiologie et de pneumologie de Québec, 2725 chemin Sainte-Foy, Québec, QC, Canada, G1V 4G5. Piscitelli F; Institute of Biomolecular Chemistry, Via Campi Flegrei, 34 80078 Pozzuoli (NA), Italy. Marzo VD; Département de Médecine, Université Laval, 1050 Avenue de la Médecine, Québec, QC, Canada, G1V 0A6; Institut universitaire de cardiologie et de pneumologie de Québec, 2725 chemin Sainte-Foy, Québec, QC, Canada, G1V 4G5; Institute of Biomolecular Chemistry, Via Campi Flegrei, 34 80078 Pozzuoli (NA), Italy; Faculté des sciences de l'agriculture et de l'alimentation, Université Laval, 2425 Rue de l'Agriculture Bureau 1122, Québec, QC, Canada, G1V 0A6; Institut sur la Nutrition et les Aliments Fonctionnels, 440 Boulevard Hochelaga, Québec, QC, Canada, G1V 0A6. Yamazaki M; Dept. of Cellular Neurobiology (currently Dept. of Animal Model Development), Brain Research Institute, Niigata University, Niigata, 951-8585 Japan; Dept of Neurology, University of California at San Francisco, San Francisco, CA, United States. Sakimura K; Dept. of Cellular Neurobiology (currently Dept. of Animal Model Development), Brain Research Institute, Niigata University, Niigata, 951-8585 Japan. Inoue Y; Dept. of Cellular Neurobiology (currently Dept. of Animal Model Development), Brain Research Institute, Niigata University, Niigata, 951-8585 Japan. Watanabe K; Faculty of Nutrition, Kobe Gakuin University, Kobe, 651-2180, Japan. Overby DR; Dept. of Bioengineering, Imperial College London, Prince Consort Road, South Kensington, London, SW7 2AZ, United Kingdom.
Source attributed case-control study of campylobacteriosis in New Zealand.
Autorzy :
Lake RJ; Risk Assessment and Social Systems Group, Institute of Environmental Science and Research, Christchurch Science Centre, 27 Creyke Road, Ilam, Christchurch 8041, New Zealand; New Zealand Food Safety Science and Research Centre, School of Veterinary Science, Massey University, New Zealand. Electronic address: . Campbell DM; New Zealand Food Safety, Ministry of Primary Industries, PO Box 2526, Wellington 6140, New Zealand. Hathaway SC; New Zealand Food Safety, Ministry of Primary Industries, PO Box 2526, Wellington 6140, New Zealand. Ashmore E; Risk Assessment and Social Systems Group, Institute of Environmental Science and Research, Christchurch Science Centre, 27 Creyke Road, Ilam, Christchurch 8041, New Zealand. Cressey PJ; Risk Assessment and Social Systems Group, Institute of Environmental Science and Research, Christchurch Science Centre, 27 Creyke Road, Ilam, Christchurch 8041, New Zealand. Horn BJ; Risk Assessment and Social Systems Group, Institute of Environmental Science and Research, Christchurch Science Centre, 27 Creyke Road, Ilam, Christchurch 8041, New Zealand. Pirikahu S; School of Population and Global Health, The University of Western Australia, 35 Stirling Hwy, Crawley WA, Perth, Australia. SherwoodJM; Institute of Environmental Science and Research, Kenepuru Science Centre, PO Box 50348, Porirua 5240, New Zealand. Baker MG; University of Otago, Wellington, Box 7343, Wellington, 6242, New Zealand. Shoemack P; Bay of Plenty District Health Board, PO Box 2120, Tauranga, 3140, New Zealand. Benschop J; Tāwharau Ora, School of Veterinary Science, Massey University, Private Bag 11-222, Palmerston North, 4442, New Zealand. Marshall JC; School of Fundamental Sciences, Massey University, Tennent Drive, Palmerston North, 4474, New Zealand. Midwinter AC; Tāwharau Ora, School of Veterinary Science, Massey University, Private Bag 11-222, Palmerston North, 4442, New Zealand. Wilkinson DA; Tāwharau Ora, School of Veterinary Science, Massey University, Private Bag 11-222, Palmerston North, 4442, New Zealand. French NP; New Zealand Food Safety Science and Research Centre, School of Veterinary Science, Massey University, New Zealand; Tāwharau Ora, School of Veterinary Science, Massey University, Private Bag 11-222, Palmerston North, 4442, New Zealand.
The Ocular Pulse Decreases Aqueous Humour Outflow Resistance by Stimulating Nitric Oxide Production.
Autorzy :
Madekurozwa M; Dept. of Bioengineering, Imperial College London, London, SW7 2AZ, United Kingdom. Stamer WD; Dept. of Ophthalmology, Duke University, Durham, NC, United States. Reina-Torres E; Dept. of Bioengineering, Imperial College London, London, SW7 2AZ, United Kingdom. SherwoodJM; Dept. of Bioengineering, Imperial College London, London, SW7 2AZ, United Kingdom. Overby DR; Dept. of Bioengineering, Imperial College London, London, SW7 2AZ, United Kingdom.
The role of Piezo1 in conventional aqueous humor outflow dynamics.
Autorzy :
Zhu W; Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, Shandong, China.; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University & Capital Medical University, Beijing 100730, China. Hou F; Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, Shandong, China.; Department of Pharmacy, Affiliated Hospital of Qingdao University, Qingdao 266003, China. Fang J; Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, Shandong, China. Bahrani Fard MR; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta 30332, GA, USA. Liu Y; Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, Shandong, China. Ren S; Department of Pharmacy, Affiliated Hospital of Qingdao University, Qingdao 266003, China. Wu S; Beijing Institute of Ophthalmology, Beijing Tongren Hospital Eye Center, Beijing 100730 China. Qi Y; Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, Shandong, China. Sui S; Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, Shandong, China. Read AT; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta 30332, GA, USA. SherwoodJM; Department of Bioengineering, Imperial College London, London, UK. Zou W; School of Mechatronic Engineering, Jiangsu Normal University, Xuzhou 221116, China. Yu H; Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, Shandong, China. Zhang J; Beijing Institute of Ophthalmology, Beijing Tongren Hospital Eye Center, Beijing 100730 China. Overby DR; Department of Bioengineering, Imperial College London, London, UK. Wang N; Beijing Institute of Ophthalmology, Beijing Tongren Hospital Eye Center, Beijing 100730 China. Ethier CR; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta 30332, GA, USA.; Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, 30332, GA, United States. Wang K; Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, Shandong, China.; Institute of Innovative Drugs, Qingdao University, 38 Dengzhou Road, Qingdao 266021, Shandong, China.
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Źródło :
IScience [iScience] 2021 Jan 07; Vol. 24 (2), pp. 102042. Date of Electronic Publication: 2021 Jan 07 (Print Publication: 2021).
The role of EP 2 receptors in mediating the ultra-long-lasting intraocular pressure reduction by JV-GL1.
Autorzy :
Bertrand JA; Dept. of Bioengineering, Imperial College London, London, UK. Woodward DF; Dept. of Bioengineering, Imperial College London, London, UK.; JeniVision Inc, Suite 200, Irvine, California, USA. SherwoodJM; Dept. of Bioengineering, Imperial College London, London, UK. Wang JW; JeniVision Inc, Suite 200, Irvine, California, USA. Overby DR; Dept. of Bioengineering, Imperial College London, London, UK .
siRNA targeting Schlemm's canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model.
Autorzy :
Cassidy PS; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. Kelly RA; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. Reina-Torres E; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.; Department of Bioengineering, Imperial College London, London, UK. SherwoodJM; Department of Bioengineering, Imperial College London, London, UK. Humphries MM; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. Kiang AS; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. Farrar GJ; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. O'Brien C; Department of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland. Campbell M; Neurovascular Research Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. Stamer WD; Department of Ophthalmology, Duke University, Durham, NC, USA. Overby DR; Department of Bioengineering, Imperial College London, London, UK. Humphries P; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. O'Callaghan J; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.; Neurovascular Research Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
Aqueous Humor Outflow Requires Active Cellular Metabolism in Mice.
Autorzy :
Reina-Torres E; Department of Bioengineering, Imperial College London, London, United Kingdom. Boussommier-Calleja A; Department of Bioengineering, Imperial College London, London, United Kingdom.; ImVitro, Paris, France. SherwoodJM; Department of Bioengineering, Imperial College London, London, United Kingdom. Overby DR; Department of Bioengineering, Imperial College London, London, United Kingdom.
Integral role for lysyl oxidase-like-1 in conventional outflow tissue function and behavior.
Autorzy :
Li G; Department of Ophthalmology, Duke University, Durham, NC, USA. Schmitt H; Department of Ophthalmology, Duke University, Durham, NC, USA. Johnson WM; Department of Ophthalmology, Duke University, Durham, NC, USA. Lee C; Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, USA. Navarro I; Department of Ophthalmology, Duke University, Durham, NC, USA. Cui J; East Chapel Hill School, Chapel Hill, NC, USA. Fleming T; Department of Ophthalmology, Duke University, Durham, NC, USA. Gomez-Caraballo M; Department of Ophthalmology, Duke University, Durham, NC, USA. Elliott MH; Department of Ophthalmology and Physiology, University of Oklahoma Health, Oklahoma City, OK, USA. SherwoodJM; Department of Bioengineering, Imperial College London, London, UK. Hauser MA; Department of Ophthalmology, Duke University, Durham, NC, USA.; Molecular Physiology Institute, Duke University, Durham, NC, USA. Farsiu S; Department of Ophthalmology, Duke University, Durham, NC, USA.; Department of Biomedical Engineering, Duke University, Durham, NC, USA. Ethier CR; Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, USA. Stamer WD; Department of Ophthalmology, Duke University, Durham, NC, USA.; Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Shear Stress in Schlemm's Canal as a Sensor of Intraocular Pressure.
Autorzy :
McDonnell F; Duke Eye Center, Durham, North Carolina, USA. Perkumas KM; Duke Eye Center, Durham, North Carolina, USA. Ashpole NE; Duke Eye Center, Durham, North Carolina, USA. Kalnitsky J; Duke Eye Center, Durham, North Carolina, USA. SherwoodJM; Bioengineering, Imperial College London, London, UK. Overby DR; Bioengineering, Imperial College London, London, UK. Stamer WD; Duke Eye Center, Durham, North Carolina, USA. .; Biomedical Engineering, Duke University, Durham, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Apr 02; Vol. 10 (1), pp. 5804. Date of Electronic Publication: 2020 Apr 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Measurement of Ocular Compliance Using iPerfusion.
Autorzy :
SherwoodJM; Department of Bioengineering, Imperial College London, London, United Kingdom. Boazak EM; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States. Feola AJ; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States.; Atlanta VA Medical Center, Atlanta, GA, United States. Parker K; Department of Bioengineering, Imperial College London, London, United Kingdom. Ethier CR; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States.; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, United States. Overby DR; Department of Bioengineering, Imperial College London, London, United Kingdom.
Reduced humidity experienced by mice in vivo coincides with reduced outflow facility measured ex vivo.
Autorzy :
Reina-Torres E; Department of Bioengineering, Imperial College London, London, United Kingdom; Ocular Genetics Unit, Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, Ireland. Bertrand JA; Department of Bioengineering, Imperial College London, London, United Kingdom. O'Callaghan J; Ocular Genetics Unit, Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, Ireland. SherwoodJM; Department of Bioengineering, Imperial College London, London, United Kingdom. Humphries P; Ocular Genetics Unit, Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, Ireland. Overby DR; Department of Bioengineering, Imperial College London, London, United Kingdom. Electronic address: .
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Źródło :
Experimental eye research [Exp Eye Res] 2019 Sep; Vol. 186, pp. 107745. Date of Electronic Publication: 2019 Jul 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Development and validation of a hemangiosarcoma likelihood prediction model in dogs presenting with spontaneous hemoabdomen: The HeLP score.
Autorzy :
Schick AR; Cornell University College of Veterinary Medicine, Ithaca, New York. Hayes GM; Cornell University College of Veterinary Medicine, Ithaca, New York. Singh A; Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada. Mathews KG; North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina. Higginbotham ML; Sugar Land Vet Specialists, Sugar Land, Texas. SherwoodJM; VCA Oso Creek Animal Hospital & Emergency Center, Corpus Christi, Texas.
A model of the oscillatory mechanical forces in the conventional outflow pathway.
Autorzy :
SherwoodJM; 1 Department of Bioengineering, Imperial College London , London , UK. Stamer WD; 2 Department of Ophthalmology, Duke University , Durham, NC , USA. Overby DR; 1 Department of Bioengineering, Imperial College London , London , UK.
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