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    Wyświetlanie 1-8 z 8
    Podgląd okładki
    Tytuł :
    Novel myostatin-specific antibody enhances muscle strength in muscle disease models.
    Autorzy :
    Muramatsu H; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan.
    Kuramochi T; Chugai Pharmabody Research Pte. Ltd., 3 Biopolis Drive, #07-11 to 16, Synapse, Singapore, 138623, Singapore.
    Katada H; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan.
    Ueyama A; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan.
    Ruike Y; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan.
    Ohmine K; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan.
    Shida-Kawazoe M; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan.
    Miyano-Nishizawa R; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan.
    Shimizu Y; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan.
    Okuda M; Chugai Pharmabody Research Pte. Ltd., 3 Biopolis Drive, #07-11 to 16, Synapse, Singapore, 138623, Singapore.
    Hori Y; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan.
    Hayashi M; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan.
    Haraya K; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan.
    Ban N; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan.
    Nonaka T; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan.
    Honda M; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan.
    Kitamura H; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan.
    Hattori K; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan.
    Kitazawa T; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan.
    Igawa T; Chugai Pharmabody Research Pte. Ltd., 3 Biopolis Drive, #07-11 to 16, Synapse, Singapore, 138623, Singapore.
    Kawabe Y; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan.
    Nezu J; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, 103-8324, Japan. .
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    Źródło :
    Scientific reports [Sci Rep] 2021 Jan 25; Vol. 11 (1), pp. 2160. Date of Electronic Publication: 2021 Jan 25.
    Typ publikacji :
    Journal Article
    Czasopismo naukowe
    Szczegóły Pełny tekst Pełny tekst
    Podgląd okładki
    Tytuł :
    Antibody to CD137 Activated by Extracellular Adenosine Triphosphate Is Tumor Selective and Broadly Effective In Vivo without Systemic Immune Activation.
    Autorzy :
    Kamata-Sakurai M; Translational Research Division, Chugai Pharmaceutical Co., Ltd., Chuo-ku, Tokyo, Japan. .
    Narita Y; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Hori Y; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Nemoto T; Translational Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Uchikawa R; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Honda M; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Hironiwa N; Chugai Pharmabody Research Pte. Ltd., Synapse, Singapore.
    Taniguchi K; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Shida-Kawazoe M; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Metsugi S; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Miyazaki T; Clinical Development Division, Chugai Pharmaceutical Co., Ltd., Tokyo, Japan.
    Wada NA; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Ohte Y; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Shimizu S; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Mikami H; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Tachibana T; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Ono N; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Adachi K; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Sakiyama T; Pharmaceutical Technology Division, Chugai Pharmaceutical Co., Ltd., Kita-ku, Tokyo, Japan.
    Matsushita T; Translational Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Kadono S; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Komatsu SI; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Sakamoto A; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Horikawa S; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Hirako A; Translational Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Hamada K; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Naoi S; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Savory N; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Satoh Y; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Sato M; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Noguchi Y; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Shinozuka J; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Kuroi H; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Ito A; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Wakabayashi T; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Kamimura M; Chugai Research Institute for Medical Science, Inc., Kamakura, Kanagawa, Japan.
    Isomura F; Chugai Research Institute for Medical Science, Inc., Gotemba, Shizuoka, Japan.
    Tomii Y; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Sawada N; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Kato A; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Ueda O; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Nakanishi Y; Project & Lifecycle Management Unit, Chugai Pharmaceutical Co., Ltd., Chuo-ku, Tokyo, Japan.
    Endo M; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Jishage KI; Chugai Research Institute for Medical Science, Inc., Kamakura, Kanagawa, Japan.; Chugai Research Institute for Medical Science, Inc., Gotemba, Shizuoka, Japan.
    Kawabe Y; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Kitazawa T; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Igawa T; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.; Chugai Pharmabody Research Pte. Ltd., Synapse, Singapore.
    Pokaż więcej
    Źródło :
    Cancer discovery [Cancer Discov] 2020 Aug 25. Date of Electronic Publication: 2020 Aug 25.
    Typ publikacji :
    Journal Article
    Czasopismo naukowe
    Szczegóły
    Podgląd okładki
    Tytuł :
    Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody.
    Autorzy :
    Sampei Z; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Haraya K; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Tachibana T; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Fukuzawa T; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Shida-Kawazoe M; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Gan SW; Chugai Pharmabody Research Pte. Ltd., Singapore, Singapore.
    Shimizu Y; Chugai Pharmabody Research Pte. Ltd., Singapore, Singapore.
    Ruike Y; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Feng S; Chugai Pharmabody Research Pte. Ltd., Singapore, Singapore.
    Kuramochi T; Chugai Pharmabody Research Pte. Ltd., Singapore, Singapore.
    Muraoka M; Chugai Pharmabody Research Pte. Ltd., Singapore, Singapore.
    Kitazawa T; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Kawabe Y; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Igawa T; Chugai Pharmabody Research Pte. Ltd., Singapore, Singapore.
    Hattori K; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Nezu J; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Pokaż więcej
    Źródło :
    PloS one [PLoS One] 2018 Dec 28; Vol. 13 (12), pp. e0209509. Date of Electronic Publication: 2018 Dec 28 (Print Publication: 2018).
    Typ publikacji :
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms :
    Antibodies, Monoclonal/*genetics
    Complement Activation/*drug effects
    Complement C5/*antagonists & inhibitors
    Protein Engineering/*methods
    Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/therapeutic use ; Antibody Affinity ; Complement Activation/immunology ; Complement C5/immunology ; Complement C5/isolation & purification ; Computer Simulation ; Drug Discovery/methods ; Endosomes/immunology ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/immunology ; Humans ; Hydrogen-Ion Concentration ; Immune System Diseases/drug therapy ; Immune System Diseases/immunology ; Macaca fascicularis ; Mice ; Mice, Transgenic ; Mutagenesis ; Receptors, Fc/genetics ; Receptors, Fc/immunology ; Recombinant Proteins/immunology ; Recombinant Proteins/isolation & purification ; Time Factors
    Czasopismo naukowe
    Szczegóły Pełny tekst Pełny tekst
    Podgląd okładki
    Tytuł :
    Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases.
    Autorzy :
    Fukuzawa T; Chugai Pharmabody Research Pte. Ltd., 3 Biopolis Drive, #07-11 to 16, Synapse, 138623, Singapore.
    Sampei Z; Chugai Pharmabody Research Pte. Ltd., 3 Biopolis Drive, #07-11 to 16, Synapse, 138623, Singapore.
    Haraya K; Chugai Pharmabody Research Pte. Ltd., 3 Biopolis Drive, #07-11 to 16, Synapse, 138623, Singapore.
    Ruike Y; Chugai Pharmabody Research Pte. Ltd., 3 Biopolis Drive, #07-11 to 16, Synapse, 138623, Singapore.
    Shida-Kawazoe M; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Shimizu Y; Chugai Pharmabody Research Pte. Ltd., 3 Biopolis Drive, #07-11 to 16, Synapse, 138623, Singapore.
    Gan SW; Chugai Pharmabody Research Pte. Ltd., 3 Biopolis Drive, #07-11 to 16, Synapse, 138623, Singapore.
    Irie M; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Tsuboi Y; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Tai H; Chugai Research Institute for Medical Science, Inc., Gotemba, Shizuoka, Japan.
    Sakiyama T; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Sakamoto A; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Ishii S; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Maeda A; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Iwayanagi Y; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Shibahara N; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Shibuya M; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Nakamura G; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Nambu T; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Hayasaka A; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Mimoto F; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Okura Y; Chugai Pharmabody Research Pte. Ltd., 3 Biopolis Drive, #07-11 to 16, Synapse, 138623, Singapore.
    Hori Y; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Habu K; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Wada M; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Miura T; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Tachibana T; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Honda K; Chugai Pharmabody Research Pte. Ltd., 3 Biopolis Drive, #07-11 to 16, Synapse, 138623, Singapore.
    Tsunoda H; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Kitazawa T; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Kawabe Y; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Igawa T; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
    Hattori K; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
    Nezu J; Chugai Pharmabody Research Pte. Ltd., 3 Biopolis Drive, #07-11 to 16, Synapse, 138623, Singapore. .
    Pokaż więcej
    Źródło :
    Scientific reports [Sci Rep] 2017 Apr 24; Vol. 7 (1), pp. 1080. Date of Electronic Publication: 2017 Apr 24.
    Typ publikacji :
    Journal Article
    MeSH Terms :
    Antibodies, Neutralizing/*immunology
    Complement C5/*antagonists & inhibitors
    Complement C5/*immunology
    Animals ; Antibodies, Neutralizing/administration & dosage ; Antibodies, Neutralizing/chemistry ; Complement C5/chemistry ; Crystallography, X-Ray ; Hemoglobinuria, Paroxysmal/drug therapy ; Humans ; Macaca fascicularis ; Protein Binding ; Protein Conformation
    Czasopismo naukowe
    Szczegóły
    Podgląd okładki
    Tytuł :
    Novel asymmetrically engineered antibody Fc variant with superior FcγR binding affinity and specificity compared with afucosylated Fc variant.
    Autorzy :
    Mimoto F; Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, Japan.
    Igawa T
    Kuramochi T
    Katada H
    Kadono S
    Kamikawa T
    Shida-Kawazoe M
    Hattori K
    Pokaż więcej
    Źródło :
    MAbs [MAbs] 2013 Mar-Apr; Vol. 5 (2), pp. 229-36. Date of Electronic Publication: 2013 Feb 13.
    Typ publikacji :
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms :
    Antibody Affinity*
    Antibody Specificity*
    Antibodies, Monoclonal/*genetics
    Immunoglobulin Fc Fragments/*genetics
    Protein Engineering/*methods
    Receptors, IgG/*metabolism
    Amino Acid Substitution ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/metabolism ; Antibody-Dependent Cell Cytotoxicity ; Cell Line ; Fucose/metabolism ; Genetic Variation ; Humans ; Immunoglobulin Fc Fragments/chemistry ; Immunoglobulin Fc Fragments/metabolism ; Protein Binding
    Czasopismo naukowe
    Szczegóły
      Wyświetlanie 1-8 z 8

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