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Tytuł :
Factors associated with recurrence in patients with curatively resected stage I-II lung cancer.
Autorzy :
Koo HK; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Jongno-gu, Seoul, Republic of Korea.
Jin SM
Lee CH
Lim HJ
Yim JJ
Kim YT
Yang SC
Yoo CG
Han SK
Kim JH
Shim YS
Kim YW
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Źródło :
Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2011 Aug; Vol. 73 (2), pp. 222-9. Date of Electronic Publication: 2010 Dec 18.
Typ publikacji :
Journal Article
MeSH Terms :
Neoplasm Recurrence, Local*
Carcinoma, Non-Small-Cell Lung/*surgery
Lung Neoplasms/*surgery
Aged ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; ROC Curve ; Retrospective Studies ; Risk Factors ; Treatment Failure
Czasopismo naukowe
Tytuł :
Risk factors of postoperative pneumonia after lung cancer surgery.
Autorzy :
Lee JY; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul, Korea.
Jin SM
Lee CH
Lee BJ
Kang CH
Yim JJ
Kim YT
Yang SC
Yoo CG
Han SK
Kim JH
Shim YS
Kim YW
Pokaż więcej
Źródło :
Journal of Korean medical science [J Korean Med Sci] 2011 Aug; Vol. 26 (8), pp. 979-84. Date of Electronic Publication: 2011 Jul 27.
Typ publikacji :
Journal Article
MeSH Terms :
Postoperative Complications*
Lung Neoplasms/*surgery
Pneumonia/*etiology
Adult ; Age Factors ; Aged ; Aged, 80 and over ; C-Reactive Protein/analysis ; Carbon Monoxide/metabolism ; Erythrocyte Transfusion ; Female ; Forced Expiratory Volume ; Hospital Mortality ; Humans ; Incidence ; Logistic Models ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Odds Ratio ; Pneumonia/epidemiology ; Pneumonia/mortality ; Retrospective Studies ; Risk Factors ; Vital Capacity
Czasopismo naukowe
Tytuł :
Impact of parenchymal tuberculosis sequelae on mediastinal lymph node staging in patients with lung cancer.
Autorzy :
Lee SH; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul, Korea.
Min JW
Lee CH
Park CM
Goo JM
Chung DH
Kang CH
Kim YT
Kim YW
Han SK
Shim YS
Yim JJ
Pokaż więcej
Źródło :
Journal of Korean medical science [J Korean Med Sci] 2011 Jan; Vol. 26 (1), pp. 67-70. Date of Electronic Publication: 2010 Dec 22.
Typ publikacji :
Journal Article
MeSH Terms :
Latent Tuberculosis/*complications
Lung Neoplasms/*diagnosis
Aged ; Aged, 80 and over ; Female ; Fluorodeoxyglucose F18 ; Humans ; Latent Tuberculosis/pathology ; Lung Neoplasms/complications ; Lung Neoplasms/pathology ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Male ; Mediastinum ; Middle Aged ; Neoplasm Staging ; Positron-Emission Tomography ; Predictive Value of Tests ; Radiopharmaceuticals ; Sensitivity and Specificity ; Tomography, X-Ray Computed
Czasopismo naukowe
Tytuł :
Impact of whole-body ¹⁸F-fluorodeoxyglucose positron emission tomography on therapeutic management of non-small cell lung cancer.
Autorzy :
Heo EY; Division of Pulmonary and Critical Care Medicine, Department of Medicine and Lung Institute, Seoul National University College of Medicine, Jongno-gu, Seoul, Republic of Korea.
Yang SC
Yoo CG
Han SK
Shim YS
Kim YW
Pokaż więcej
Źródło :
Respirology (Carlton, Vic.) [Respirology] 2010 Nov; Vol. 15 (8), pp. 1174-8.
Typ publikacji :
Journal Article
MeSH Terms :
Fluorodeoxyglucose F18*
Radiopharmaceuticals*
Carcinoma, Non-Small-Cell Lung/*diagnostic imaging
Carcinoma, Non-Small-Cell Lung/*therapy
Lung Neoplasms/*diagnostic imaging
Lung Neoplasms/*therapy
Positron-Emission Tomography/*methods
Whole Body Imaging/*methods
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung/pathology ; Female ; Humans ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Costs for 5-year lung cancer survivors in a tertiary care hospital in South Korea.
Autorzy :
Park YS; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea.
Kim SH
Park SK
Park BJ
Kim YT
Lee SM
Yim JJ
Yoo CG
Kim YW
Han SK
Shim YS
Yang SC
Pokaż więcej
Źródło :
Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2010 May; Vol. 68 (2), pp. 299-304. Date of Electronic Publication: 2009 Jul 30.
Typ publikacji :
Journal Article
MeSH Terms :
Health Care Costs*
Carcinoma, Non-Small-Cell Lung/*economics
Lung Neoplasms/*economics
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/physiopathology ; Carcinoma, Non-Small-Cell Lung/therapy ; Cost of Illness ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Insurance Claim Review/statistics & numerical data ; Lung Neoplasms/pathology ; Lung Neoplasms/physiopathology ; Lung Neoplasms/therapy ; Male ; Middle Aged ; Neoplasm Staging ; Republic of Korea ; Retrospective Studies ; Time Factors
Czasopismo naukowe
Tytuł :
Clinical significance of non-diagnostic pathology results from percutaneous transthoracic needle lung biopsy: experience of a tertiary hospital without an on-site cytopathologist.
Autorzy :
Min JW; Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
Lee SM
Chung DH
Yim JJ
Yang SC
Yoo CG
Kim YW
Han SK
Shim YS
Chung HS
Pokaż więcej
Źródło :
Respirology (Carlton, Vic.) [Respirology] 2009 Sep; Vol. 14 (7), pp. 1042-50.
Typ publikacji :
Evaluation Study; Journal Article
MeSH Terms :
Biopsy, Needle/*methods
Lung/*pathology
Lung Neoplasms/*diagnosis
Lung Neoplasms/*pathology
Pathology, Clinical/*methods
Aged ; Clinical Competence ; Diagnostic Errors/prevention & control ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Outcome Assessment, Health Care ; Probability ; Prognosis ; Retrospective Studies
Czasopismo naukowe
Tytuł :
The role of whole-body FDG PET/CT, Tc 99m MDP bone scintigraphy, and serum alkaline phosphatase in detecting bone metastasis in patients with newly diagnosed lung cancer.
Autorzy :
Min JW; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
Um SW
Yim JJ
Yoo CG
Han SK
Shim YS
Kim YW
Pokaż więcej
Źródło :
Journal of Korean medical science [J Korean Med Sci] 2009 Apr; Vol. 24 (2), pp. 275-80. Date of Electronic Publication: 2009 Apr 21.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Fluorodeoxyglucose F18*
Radiopharmaceuticals*
Technetium Tc 99m Medronate*
Alkaline Phosphatase/*blood
Bone Neoplasms/*secondary
Lung Neoplasms/*diagnosis
Aged ; Bone Neoplasms/diagnosis ; Bone Neoplasms/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Small Cell/diagnosis ; Carcinoma, Small Cell/pathology ; Female ; Humans ; Lung Neoplasms/pathology ; Male ; Medical Records ; Middle Aged ; Neoplasm Staging ; Positron-Emission Tomography ; Retrospective Studies ; Sensitivity and Specificity ; Tomography, X-Ray Computed ; Whole Body Imaging/methods
Czasopismo naukowe
Tytuł :
Solid-organ malignancy as a risk factor for tuberculosis.
Autorzy :
Kim HR; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Jongno-gu, Seoul 110-744, Korea.
Hwang SS
Ro YK
Jeon CH
Ha DY
Park SJ
Lee CH
Lee SM
Yoo CG
Kim YW
Han SK
Shim YS
Yim JJ
Pokaż więcej
Źródło :
Respirology (Carlton, Vic.) [Respirology] 2008 May; Vol. 13 (3), pp. 413-9.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*epidemiology
Colonic Neoplasms/*epidemiology
Liver Neoplasms/*epidemiology
Lung Neoplasms/*epidemiology
Stomach Neoplasms/*epidemiology
Tuberculosis, Pulmonary/*epidemiology
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/therapeutic use ; Breast Neoplasms/drug therapy ; Case-Control Studies ; Cohort Studies ; Colonic Neoplasms/drug therapy ; Drug Therapy ; Female ; Humans ; Immunosuppression ; Liver Neoplasms/drug therapy ; Lung Neoplasms/drug therapy ; Male ; Middle Aged ; Regression Analysis ; Retrospective Studies ; Risk Factors ; Stomach Neoplasms/drug therapy
Czasopismo naukowe
Tytuł :
Small solid noncalcified pulmonary nodules detected by screening chest computed tomography.
Autorzy :
Jin SM; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea.
Choi SH
Yoo CG
Kim YW
Han SK
Shim YS
Lee SM
Pokaż więcej
Źródło :
Respiratory medicine [Respir Med] 2007 Sep; Vol. 101 (9), pp. 1880-4. Date of Electronic Publication: 2007 Jun 27.
Typ publikacji :
Journal Article
MeSH Terms :
Lung Neoplasms/*diagnostic imaging
Solitary Pulmonary Nodule/*diagnostic imaging
Adult ; Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Humans ; Lung Neoplasms/etiology ; Lung Neoplasms/pathology ; Male ; Mass Screening/methods ; Middle Aged ; Risk Assessment/methods ; Smoking/adverse effects ; Solitary Pulmonary Nodule/etiology ; Solitary Pulmonary Nodule/pathology ; Tomography, X-Ray Computed
Czasopismo naukowe
Tytuł :
Adenovirus expressing shRNA to IGF-1R enhances the chemosensitivity of lung cancer cell lines by blocking IGF-1 pathway.
Autorzy :
Lee YJ; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea.
Imsumran A
Park MY
Kwon SY
Yoon HI
Lee JH
Yoo CG
Kim YW
Han SK
Shim YS
Piao W
Yamamoto H
Adachi Y
Carbone DP
Lee CT
Pokaż więcej
Źródło :
Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2007 Mar; Vol. 55 (3), pp. 279-86. Date of Electronic Publication: 2006 Nov 28.
Typ publikacji :
Journal Article
MeSH Terms :
RNA Interference*
Adenoviridae/*genetics
Lung Neoplasms/*metabolism
RNA, Small Interfering/*pharmacology
Receptor, IGF Type 1/*antagonists & inhibitors
Antineoplastic Agents/therapeutic use ; Apoptosis ; Base Sequence ; Caspase 3/drug effects ; Caspase 3/metabolism ; Cell Line, Tumor ; Genetic Therapy/methods ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Molecular Sequence Data ; Phosphorylation ; RNA, Messenger/metabolism ; RNA, Viral/metabolism ; Receptor, IGF Type 1/metabolism ; Signal Transduction/physiology ; Transduction, Genetic
Czasopismo naukowe
Tytuł :
Bronchial washing yield before and after forceps biopsy in patients with endoscopically visible lung cancers.
Autorzy :
Lee HS; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University Hospital, Seoul, Republic of Korea.
Kwon SY
Kim DK
Yoon HI
Lee SM
Lee JH
Lee CT
Chung HS
Han SK
Shim YS
Yim JJ
Pokaż więcej
Źródło :
Respirology (Carlton, Vic.) [Respirology] 2007 Mar; Vol. 12 (2), pp. 277-82.
Typ publikacji :
Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms :
Bronchoscopy*
Bronchoalveolar Lavage/*methods
Bronchoalveolar Lavage Fluid/*cytology
Lung Neoplasms/*pathology
Adult ; Aged ; Aged, 80 and over ; Biopsy/instrumentation ; Diagnosis, Differential ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prospective Studies
Czasopismo naukowe
Tytuł :
Determinants of diagnostic bronchial washing in peripheral lung cancers.
Autorzy :
Lee HS; Division of Respiratory and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul, South Korea.
Kwon SY
Kim DK
Yoon HI
Lee SM
Lee JH
Lee CT
Chung HS
Han SK
Shim YS
Yim JJ
Pokaż więcej
Źródło :
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2007 Feb; Vol. 11 (2), pp. 227-32.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Bronchoalveolar Lavage*
Bronchoscopy*
Lung Neoplasms/*diagnosis
Bronchography ; Female ; Humans ; Logistic Models ; Lung Neoplasms/diagnostic imaging ; Male ; Middle Aged ; Tomography, X-Ray Computed
Czasopismo naukowe
Tytuł :
Clinical significance of a solitary ground-glass opacity (GGO) lesion of the lung detected by chest CT.
Autorzy :
Oh JY; Division of Pulmonology and Critical Care, Department of Internal Medicine and Lung Institute of Medical Research Center, College of Medicine, and Department of Medicine, Seoul National University Bundang Hospital, Republic of Korea.
Kwon SY
Yoon HI
Lee SM
Yim JJ
Lee JH
Yoo CG
Kim YW
Han SK
Shim YS
Kim TJ
Lee KW
Chung JH
Jheon SH
Sung SW
Lee CT
Pokaż więcej
Źródło :
Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2007 Jan; Vol. 55 (1), pp. 67-73. Date of Electronic Publication: 2006 Nov 07.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Lung/*pathology
Lung Neoplasms/*diagnostic imaging
Lung Neoplasms/*pathology
Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Risk Factors ; Tomography, X-Ray Computed
Czasopismo naukowe
Tytuł :
Hypoxia confers protection against apoptosis via PI3K/Akt and ERK pathways in lung cancer cells.
Autorzy :
Lee SM; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-799, South Korea.
Lee CT
Kim YW
Han SK
Shim YS
Yoo CG
Pokaż więcej
Źródło :
Cancer letters [Cancer Lett] 2006 Oct 28; Vol. 242 (2), pp. 231-8. Date of Electronic Publication: 2006 Jan 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Hypoxia*
Extracellular Signal-Regulated MAP Kinases/*metabolism
Lung Neoplasms/*enzymology
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Cell Line, Tumor ; Cell Survival ; DNA Fragmentation ; Enzyme Inhibitors/pharmacology ; Etoposide/pharmacology ; Flow Cytometry ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Ultraviolet Rays
Czasopismo naukowe
Tytuł :
Clinical characteristics of a second small nodule(s) associated with cT1-2N0M0 non-small-cell lung cancer.
Autorzy :
Yoon HI; Department of Internal Medicine, Seoul National University Bundang Hospital, Geonggi-do, Seongnam-si, 463-707, Republic of Korea. />Yim JJ
Lee CT
Kim YW
Han SK
Shim YS
Kim YT
Sung SW
Kim JH
Yoo CG
Pokaż więcej
Źródło :
Lung [Lung] 2006 Sep-Oct; Vol. 184 (5), pp. 273-8.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*pathology
Lung Neoplasms/*pathology
Adult ; Aged ; Biopsy ; Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Female ; Humans ; Lung Neoplasms/diagnostic imaging ; Male ; Middle Aged ; Neoplasm Staging/methods ; Prognosis ; Retrospective Studies ; Tomography, X-Ray Computed
Czasopismo naukowe
Tytuł :
In vivo imaging of adenovirus transduction and enhanced therapeutic efficacy of combination therapy with conditionally replicating adenovirus and adenovirus-p27.
Autorzy :
Lee CT; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Korea. />Lee YJ
Kwon SY
Lee J
Kim KI
Park KH
Kang JH
Yoo CG
Kim YW
Han SK
Chung JK
Shim YS
Curiel DT
Carbone DP
Pokaż więcej
Źródło :
Cancer research [Cancer Res] 2006 Jan 01; Vol. 66 (1), pp. 372-7.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenoviridae/*physiology
Cyclin-Dependent Kinase Inhibitor p27/*genetics
Genetic Therapy/*methods
Lung Neoplasms/*therapy
Adenoviridae/genetics ; Animals ; Cyclin-Dependent Kinase Inhibitor p27/biosynthesis ; Gene Expression ; Humans ; Luciferases/biosynthesis ; Luciferases/genetics ; Luminescent Measurements ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/virology ; Mice ; Transduction, Genetic ; Virus Replication ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Adenovirus-uteroglobin suppresses COX-2 expression via inhibition of NF-kappaB activity in lung cancer cells.
Autorzy :
Yoon JM; Department of Internal Medicine, Seoul National University College of Medicine, 28 Youngon-Dong, Chongno-Gu, Seoul 110-744, Korea.
Lim JJ
Yoo CG
Lee CT
Bang YJ
Han SK
Shim YS
Kim YW
Pokaż więcej
Źródło :
Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2005 May; Vol. 48 (2), pp. 201-9. Date of Electronic Publication: 2005 Jan 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lung Neoplasms/*enzymology
Lung Neoplasms/*pathology
NF-kappa B/*metabolism
Prostaglandin-Endoperoxide Synthases/*biosynthesis
Uteroglobin/*genetics
Uteroglobin/*metabolism
Adenoviridae/genetics ; Cell Proliferation ; Cyclooxygenase 2 ; Gene Expression Profiling ; Genes, Reporter ; Humans ; Membrane Proteins ; Transcription, Genetic ; Transduction, Genetic ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Additive effect of TRAIL and p53 gene transfer on apoptosis of human lung cancer cell lines.
Autorzy :
Jang SH; Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
Seol JY
Kim CH
Yoo CG
Kim YW
Han SK
Shim YS
Lee CT
Pokaż więcej
Źródło :
International journal of molecular medicine [Int J Mol Med] 2004 Jan; Vol. 13 (1), pp. 181-6.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*physiology
Lung Neoplasms/*metabolism
Membrane Glycoproteins/*genetics
Tumor Necrosis Factor-alpha/*genetics
Tumor Suppressor Protein p53/*genetics
Adenoviridae ; Apoptosis Regulatory Proteins ; Genetic Vectors ; Humans ; Membrane Glycoproteins/metabolism ; Receptors, TNF-Related Apoptosis-Inducing Ligand ; Receptors, Tumor Necrosis Factor/metabolism ; TNF-Related Apoptosis-Inducing Ligand ; Transduction, Genetic ; Tumor Necrosis Factor-alpha/metabolism ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Tytuł :
Expression of caveolin-1 is associated with poor prognosis of patients with squamous cell carcinoma of the lung.
Autorzy :
Yoo SH; Department of Pathology, Seoul National University College of Medicine, Chongno-gu Yongon-dong 28, Seoul, South Korea.
Park YS
Kim HR
Sung SW
Kim JH
Shim YS
Lee SD
Choi YL
Kim MK
Chung DH
Pokaż więcej
Źródło :
Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2003 Nov; Vol. 42 (2), pp. 195-202.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neoplasm Staging*
Carcinoma, Non-Small-Cell Lung/*pathology
Carcinoma, Squamous Cell/*pathology
Caveolins/*biosynthesis
Lung Neoplasms/*pathology
Adult ; Aged ; Aged, 80 and over ; Caveolin 1 ; Disease Progression ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Sensitivity and Specificity ; Survival Analysis
Czasopismo naukowe

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