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Tytuł :
CD133 prevents colon cancer cell death induced by serum deprivation through activation of Akt-mediated protein synthesis and inhibition of apoptosis.
Autorzy :
Mori Y; Laboratory of Oncogenomics, Chiba Cancer Center Research Institute, Japan.
Takeuchi A; Laboratory of Oncogenomics, Chiba Cancer Center Research Institute, Japan.
Miyagawa K; Laboratory of Oncogenomics, Chiba Cancer Center Research Institute, Japan.; Department of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Japan.
Yoda H; Laboratory of Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Japan.
Soda H; Department of Esophago-Gastrointestinal Surgery, Chiba Cancer Center Hospital, Japan.
Nabeya Y; Department of Esophago-Gastrointestinal Surgery, Chiba Cancer Center Hospital, Japan.
Watanabe N; Department of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Japan.
Ozaki T; Laboratory of Oncogenomics, Chiba Cancer Center Research Institute, Japan.
Shimozato O; Laboratory of Oncogenomics, Chiba Cancer Center Research Institute, Japan.
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Źródło :
FEBS open bio [FEBS Open Bio] 2021 May; Vol. 11 (5), pp. 1382-1394. Date of Electronic Publication: 2021 Mar 28.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
PTPRK suppresses progression and chemo-resistance of colon cancer cells via direct inhibition of pro-oncogenic CD133.
Autorzy :
Matsushita M; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Japan.
Mori Y; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Japan.; Laboratory of Oncogenomics, Chiba Cancer Center Research Institute, Japan.
Uchiumi K; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Japan.
Ogata T; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Japan.
Nakamura M; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Japan.
Yoda H; Laboratory of Cancer Genetics, Chiba Cancer Center Research Institute, Japan.
Soda H; Department of Esophago-Gastrointestinal Surgery, Chiba Cancer Center Hospital, Japan.
Takiguchi N; Department of Esophago-Gastrointestinal Surgery, Chiba Cancer Center Hospital, Japan.
Nabeya Y; Department of Esophago-Gastrointestinal Surgery, Chiba Cancer Center Hospital, Japan.
Shimozato O; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Japan.; Laboratory of Oncogenomics, Chiba Cancer Center Research Institute, Japan.
Ozaki T; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Japan.; Laboratory of Oncogenomics, Chiba Cancer Center Research Institute, Japan.
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Źródło :
FEBS open bio [FEBS Open Bio] 2019 May; Vol. 9 (5), pp. 935-946. Date of Electronic Publication: 2019 Apr 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
AC133 Antigen/*genetics
Antineoplastic Agents/*pharmacology
Carcinogenesis/*genetics
Cell Proliferation/*genetics
Oxaliplatin/*pharmacology
Receptor-Like Protein Tyrosine Phosphatases, Class 2/*genetics
AC133 Antigen/metabolism ; Carcinogenesis/drug effects ; Cell Line, Tumor ; Disease Progression ; Drug Resistance ; HEK293 Cells ; HT29 Cells ; Humans ; Phosphorylation ; Receptor-Like Protein Tyrosine Phosphatases, Class 2/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Administration of DNA Encoding the Interleukin-27 Gene Augments Antitumour Responses through Non-adaptive Immunity.
Autorzy :
Li, Q.
Sato, A.
Shimozato, O.
Shingyoji, M.
Tada, Y.
Tatsumi, K.
Shimada, H.
Hiroshima, K.
Tagawa, M.
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Temat :
INTERLEUKIN-27
CANCER immunotherapy
ANTINEOPLASTIC agents
DRUG administration
NATURAL immunity
DNA
LABORATORY mice
Źródło :
Scandinavian Journal of Immunology; Oct2015, Vol. 82 Issue 4, p320-327, 8p
Czasopismo naukowe
Tytuł :
Histone deacetylase 2 is involved in DNA damage-mediated cell death of human osteosarcoma cells through stimulation of the ATM/p53 pathway.
Autorzy :
Sun D; Department of Urology The First Hospital of China Medical University Shenyang China.
Yu M; Department of Reproductive Biology and Transgenic Animal China Medical University Shenyang China.
Li Y; Department of Molecular Medicine Life Science Institute Saga Medical Center KOSEIKAN Saga Japan.
Xing H; Department of Urology The First Hospital of China Medical University Shenyang China.
Gao Y; Department of Urology The First Hospital of China Medical University Shenyang China.
Huang Z; Department of Urology The First Hospital of China Medical University Shenyang China.
Hao W; Department of Urology The First Hospital of China Medical University Shenyang China.
Lu K; Department of Urology The First Hospital of China Medical University Shenyang China.
Kong C; Department of Urology The First Hospital of China Medical University Shenyang China.
Shimozato O; Laboratory of DNA Damage Signaling Chiba Cancer Center Research Institute Chiba Japan.
Ozaki T; Laboratory of DNA Damage Signaling Chiba Cancer Center Research Institute Chiba Japan.
Zhu Y; Department of Urology The First Hospital of China Medical University Shenyang China.
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Źródło :
FEBS open bio [FEBS Open Bio] 2019 Jan 30; Vol. 9 (3), pp. 478-489. Date of Electronic Publication: 2019 Jan 30 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ataxia Telangiectasia Mutated Proteins/*metabolism
Histone Deacetylase 2/*metabolism
Lung Neoplasms/*metabolism
Osteosarcoma/*metabolism
Tumor Suppressor Protein p53/*metabolism
Antibiotics, Antineoplastic/pharmacology ; Cell Death/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; DNA Damage ; Dose-Response Relationship, Drug ; Doxorubicin/pharmacology ; Drug Screening Assays, Antitumor ; Gene Silencing/drug effects ; Histone Deacetylase 2/antagonists & inhibitors ; Histone Deacetylase 2/genetics ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Osteosarcoma/drug therapy ; Osteosarcoma/pathology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Impact of RUNX2 gene silencing on the gemcitabine sensitivity of p53‑mutated pancreatic cancer MiaPaCa‑2 spheres.
Autorzy :
Sang M; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Chiba 260‑8717, Japan.
Nakamura M; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Chiba 260‑8717, Japan.
Ogata T; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Chiba 260‑8717, Japan.
Sun D; Department of Urology, First Hospital of China Medical University, Shenyang, Liaoning110001, P.R. China.
Shimozato O; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Chiba 260‑8717, Japan.
Nikaido T; Department of Regenerative Medicine, Graduate School of Medicine, University of Toyama, Toyama 930‑0194, Japan.
Ozaki T; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Chiba 260‑8717, Japan.
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Źródło :
Oncology reports [Oncol Rep] 2018 Jun; Vol. 39 (6), pp. 2749-2758. Date of Electronic Publication: 2018 Mar 30.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*/drug effects
Core Binding Factor Alpha 1 Subunit/*genetics
Deoxycytidine/*analogs & derivatives
Pancreatic Neoplasms/*genetics
Spheroids, Cellular/*cytology
Tumor Suppressor Protein p53/*genetics
Cell Culture Techniques ; Cell Line, Tumor ; Core Binding Factor Alpha 1 Subunit/metabolism ; Deoxycytidine/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Regulatory Networks/drug effects ; Gene Silencing ; Humans ; Mutation ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/metabolism ; Signal Transduction/drug effects ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/metabolism ; Transcription Factors/genetics ; Tumor Suppressor Proteins/genetics
Czasopismo naukowe
Tytuł :
Hydrophobic structure of hairpin ten-ring pyrrole-imidazole polyamides enhances tumor tissue accumulation/retention in vivo.
Autorzy :
Inoue T; Laboratory of Cancer Genetics, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba 260-8717, Japan.
Shimozato O; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba 260-8717, Japan. Electronic address: .
Matsuo N; Laboratory of Cancer Genetics, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba 260-8717, Japan.
Mori Y; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba 260-8717, Japan.
Shinozaki Y; Laboratory of Cancer Genetics, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba 260-8717, Japan.
Lin J; Laboratory of Cancer Genetics, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba 260-8717, Japan.
Watanabe T; Laboratory of Cancer Genetics, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba 260-8717, Japan.
Takatori A; Laboratory of Cancer Genetics, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba 260-8717, Japan.
Koshikawa N; Laboratory of Cancer Genetics, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba 260-8717, Japan.
Ozaki T; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba 260-8717, Japan.
Nagase H; Laboratory of Cancer Genetics, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba 260-8717, Japan.
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2018 May 15; Vol. 26 (9), pp. 2337-2344. Date of Electronic Publication: 2018 Mar 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Imidazoles/*metabolism
Neoplasms/*metabolism
Nylons/*metabolism
Pyrroles/*metabolism
Animals ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Female ; Fluoresceins/chemical synthesis ; Fluoresceins/chemistry ; Fluoresceins/metabolism ; Fluorescence ; Fluorescent Dyes/chemical synthesis ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/metabolism ; Humans ; Hydrophobic and Hydrophilic Interactions ; Imidazoles/chemical synthesis ; Imidazoles/chemistry ; Mice, Inbred BALB C ; Molecular Structure ; Nylons/chemical synthesis ; Nylons/chemistry ; Pyrroles/chemical synthesis ; Pyrroles/chemistry ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Cancer-Type OATP1B3 mRNA in Extracellular Vesicles as a Promising Candidate for a Serum-Based Colorectal Cancer Biomarker.
Autorzy :
Morio H; Department of Pharmacology, Graduate School of Medicine, Chiba University.; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University.
Sun Y; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University.
Harada M; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University.
Ide H; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University.
Shimozato O; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute.
Zhou X; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University.
Higashi K; Department of Pharmaceutical Technology, Graduate School of Pharmaceutical Sciences, Chiba University.
Yuki R; Laboratory of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University.
Yamaguchi N; Laboratory of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University.
Hofbauer JP; EB House Austria, Research Program for the Molecular Therapy of Genodermatoses, Department of Dermatology, University Hospital of the Paracelsus Medical University Salzburg.
Guttmann-Gruber C; EB House Austria, Research Program for the Molecular Therapy of Genodermatoses, Department of Dermatology, University Hospital of the Paracelsus Medical University Salzburg.
Anzai N; Department of Pharmacology, Graduate School of Medicine, Chiba University.
Akita H; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University.
Chiba K; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University.
Furihata T; Department of Pharmacology, Graduate School of Medicine, Chiba University.; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University.
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Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2018; Vol. 41 (3), pp. 445-449.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*genetics
Colorectal Neoplasms/*blood
Extracellular Vesicles/*metabolism
RNA, Messenger/*blood
RNA, Messenger/*genetics
RNA, Neoplasm/*blood
RNA, Neoplasm/*genetics
Solute Carrier Organic Anion Transporter Family Member 1B3/*genetics
Animals ; Cell Line, Tumor ; Colorectal Neoplasms/diagnosis ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Neoplasm Transplantation ; Prognosis ; Real-Time Polymerase Chain Reaction ; Solute Carrier Organic Anion Transporter Family Member 1B3/biosynthesis
Czasopismo naukowe
Tytuł :
Cancer-type OATP1B3 mRNA has the potential to become a detection and prognostic biomarker for human colorectal cancer.
Autorzy :
Sun Y; Laboratory of Pharmacology & Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Harada M; Laboratory of Pharmacology & Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Shimozato O; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Chiba, Japan.
Souda H; Department of Gastrointestinal Surgery, Chiba Cancer Center, Chiba, Japan.
Takiguchi N; Department of Gastrointestinal Surgery, Chiba Cancer Center, Chiba, Japan.
Nabeya Y; Department of Gastrointestinal Surgery, Chiba Cancer Center, Chiba, Japan.
Kamijo T; Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan.
Akita H; Laboratory of Pharmacology & Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Anzai N; Department of Pharmacology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Chiba K; Laboratory of Pharmacology & Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Furihata T; Laboratory of Pharmacology & Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.; Department of Pharmacology, Graduate School of Medicine, Chiba University, Chiba, Japan.
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Źródło :
Biomarkers in medicine [Biomark Med] 2017 Aug; Vol. 11 (8), pp. 629-639. Date of Electronic Publication: 2017 Jun 08.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Depletion of runt-related transcription factor 2 (RUNX2) enhances SAHA sensitivity of p53-mutated pancreatic cancer cells through the regulation of mutant p53 and TAp63.
Autorzy :
Ogata T; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Chiba, Japan.
Nakamura M; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Chiba, Japan.
Sang M; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Chiba, Japan.; Department of Regenerative Medicine, Graduate School of Medicine, University of Toyama, Toyama, Japan.
Yoda H; Laboratory of Cancer Genetics, Chiba Cancer Center Research Institute, Chiba, Japan.
Hiraoka K; Laboratory of Cancer Genetics, Chiba Cancer Center Research Institute, Chiba, Japan.
Yin D; Research Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China.
Sang M; Research Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China.
Shimozato O; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Chiba, Japan.
Ozaki T; Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Chiba, Japan.
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Źródło :
PloS one [PLoS One] 2017 Jul 03; Vol. 12 (7), pp. e0179884. Date of Electronic Publication: 2017 Jul 03 (Print Publication: 2017).
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Genes, p53*
Mutation*
Core Binding Factor Alpha 1 Subunit/*physiology
Hydroxamic Acids/*pharmacology
Pancreatic Neoplasms/*pathology
Transcription Factors/*genetics
Tumor Suppressor Proteins/*genetics
Cell Line, Tumor ; Core Binding Factor Alpha 1 Subunit/genetics ; Down-Regulation ; Gene Knockdown Techniques ; Humans ; Up-Regulation ; Vorinostat
Czasopismo naukowe

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