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Tytuł :
Transcriptome analysis of gravitational effects on mouse skeletal muscles under microgravity and artificial 1 g onboard environment
Autorzy :
Okada, RisaAff1, Aff2
Fujita, Shin-ichiroAff3, Aff4
Suzuki, RikuAff5, Aff6
Hayashi, TakutoAff3, Aff5
Tsubouchi, Hirona
Kato, ChihiroAff5, Aff7
Sadaki, Shunya
Kanai, MahoAff5, Aff6
Fuseya, SayakaAff3, Aff5
Inoue, YuriAff3, Aff5
Jeon, Hyojung
Hamada, Michito
Kuno, AkihiroAff5, Aff6
Ishii, Akiko
Tamaoka, Akira
Tanihata, Jun
Ito, Naoki
Shiba, DaiAff1, Aff2
Shirakawa, MasakiAff1, Aff2
Muratani, MasafumiAff1, Aff4
Kudo, TakashiAff1, Aff5
Takahashi, SatoruAff1, Aff5
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Źródło :
Scientific Reports. 11(1)
Czasopismo naukowe
Tytuł :
Novel method for evaluating the health condition of mice in space through a video downlink.
Autorzy :
Yumoto A; Mouse Epigenetics Project, ISS/Kibo Experiment, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan.; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan.
Kokubo T; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan.; Laboratory Animal and Genome Sciences Section, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
Izumi R; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan.; Graduate School of Social and Cultural Studies, Nihon University, 12-5 Gobancho, Chiyoda-ku, Tokyo 102-8251, Japan.
Shimomura M; Mouse Epigenetics Project, ISS/Kibo Experiment, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan.; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan.
Funatsu O; Mouse Epigenetics Project, ISS/Kibo Experiment, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan.; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan.
Tada MN; Japan Manned Space Systems Corporation, 2-1-6 Sengen, Tsukuba, Ibaraki 305-0047, Japan.
Ota-Murakami N; Advanced Engineering Service, Tsukuba Mitsui Bldg., 1-6-1 Takezono, Tsukuba, Ibaraki 305-0032, Japan.
Iino K; I-NET Corp., 13F, Nissay Aroma Square, 5-37-1 Kamata, Ota-ku, Tokyo 144-8721, Japan.
Shirakawa M; Mouse Epigenetics Project, ISS/Kibo Experiment, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan.; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan.
Mizuno H; Mouse Epigenetics Project, ISS/Kibo Experiment, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan.; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan.
Kudo T; Mouse Epigenetics Project, ISS/Kibo Experiment, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan.; Laboratory Animal Resource Center in Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Takahashi S; Mouse Epigenetics Project, ISS/Kibo Experiment, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan.; Laboratory Animal Resource Center in Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Suzuki T; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-Machi, Aoba-ku, Sendai, Miyagi 980-8573, Japan.; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-Machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.
Uruno A; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-Machi, Aoba-ku, Sendai, Miyagi 980-8573, Japan.; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-Machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.
Yamamoto M; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-Machi, Aoba-ku, Sendai, Miyagi 980-8573, Japan.; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-Machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.
Shiba D; Mouse Epigenetics Project, ISS/Kibo Experiment, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan.; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan.
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Źródło :
Experimental animals [Exp Anim] 2021 May 13; Vol. 70 (2), pp. 236-244. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Author Correction: Nrf2 contributes to the weight gain of mice during space travel.
Autorzy :
Suzuki T; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Uruno A; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Yumoto A; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Taguchi K; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan.
Suzuki M; Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan.
Harada N; Institute for Animal Experimentation, Tohoku University Graduate School of Medicine, Sendai, Japan.
Ryoke R; Department of Functional Brain Imaging, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
Naganuma E; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Osanai N; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Goto A; Department of Molecular Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Suda H; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Browne R; Department of Functional Brain Imaging, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
Otsuki A; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Katsuoka F; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan.
Zorzi M; Department of Molecular Biotechnology and Health Sciences, University of Turin, 10125, Torino, Italy.
Yamazaki T; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Saigusa D; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Koshiba S; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan.
Nakamura T; Division of Molecular Pharmacology & Cell Biophysics, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Fukumoto S; Division of Pediatric Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Ikehata H; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Nishikawa K; Immunology Frontier Research Center, Osaka University, Suita, Japan.
Suzuki N; Division of Oxygen Biology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hirano I; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Molecular Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shimizu R; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Molecular Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Oishi T; Division of Oxygen Biology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Motohashi H; Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Tsubouchi H; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Okada R; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Kudo T; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Shimomura M; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Kensler TW; Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Mizuno H; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Shirakawa M; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Takahashi S; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Shiba D; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan. .
Yamamoto M; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan. .; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan. .; The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan. .
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Źródło :
Communications biology [Commun Biol] 2020 Oct 07; Vol. 3 (1), pp. 566. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Published Erratum
Tytuł :
Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight.
Autorzy :
Horie K; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Kato T; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Kudo T; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.
Sasanuma H; Laboratory of Developmental Genetics, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
Miyauchi M; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Akiyama N; Laboratory for Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Miyao T; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Seki T; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Ishikawa T; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Takakura Y; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Shirakawa M; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Ibaraki, 305-8505, Japan.
Shiba D; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Ibaraki, 305-8505, Japan.
Hamada M; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.
Jeon H; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.
Yoshida N; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.; Laboratory of Developmental Genetics, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
Inoue JI; Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
Muratani M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.; Transborder Medical Research Center, and Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.
Takahashi S; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.
Ohno H; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan. .
Akiyama T; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan. .; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan. .
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Źródło :
Scientific reports [Sci Rep] 2019 Dec 27; Vol. 9 (1), pp. 19866. Date of Electronic Publication: 2019 Dec 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gravity, Altered*
Space Flight*
Thymus Gland/*metabolism
Animals ; Base Sequence ; Enzyme-Linked Immunosorbent Assay ; Male ; Mice ; Mice, Inbred C57BL ; Principal Component Analysis ; RNA-Seq
Czasopismo naukowe
Tytuł :
Dietary intervention of mice using an improved Multiple Artificial-gravity Research System (MARS) under artificial 1  g .
Autorzy :
Matsuda C; Space Biomedical Research Group, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Kato T; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.; 3Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.
Inoue-Suzuki S; 4Institute of Nutrition Sciences, Kagawa Nutrition University, Saitama, Japan.; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Kikuchi J; 5Environmental Metabolic Analysis Research Team, RIKEN Center for Sustainable Resource Science, Yokohama, Japan.; 3Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.
Ohta T; Space Biomedical Research Group, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.; 4Institute of Nutrition Sciences, Kagawa Nutrition University, Saitama, Japan.
Kagawa M; 4Institute of Nutrition Sciences, Kagawa Nutrition University, Saitama, Japan.
Hattori M; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.; 6Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
Kobayashi H; Space Biomedical Research Group, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Shiba D; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Shirakawa M; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Mizuno H; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Furukawa S; Space Biomedical Research Group, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Mukai C; Space Biomedical Research Group, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Ohno H; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.; 3Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.
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Źródło :
NPJ microgravity [NPJ Microgravity] 2019 Jul 08; Vol. 5, pp. 16. Date of Electronic Publication: 2019 Jul 08 (Print Publication: 2019).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Dietary intervention of mice using an improved Multiple Artificial-gravity Research System (MARS) under artificial 1 g
Autorzy :
Kikuchi, Jun
Matsuda, Chie
Kato, Tamotsu
Inoue-Suzuki, Sayo
Ohta, Toshiko
Kagawa, Masaharu
Hattori, Masahira
Kobayashi, Hiroe
Shiba, Dai
Shirakawa, Masaki
Mizuno, Hiroyasu
Furukawa, Satoshi
Mukai, Chiaki
Ohno, Hiroshi
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Temat :
QP1-981
Biotechnology
Physiology
Brief Communication
Biological sciences
Health care
TP248.13-248.65
Źródło :
npj Microgravity, Vol 5, Iss 1, Pp 1-5 (2019)
Tytuł :
Down-regulation of GATA1-dependent erythrocyte-related genes in the spleens of mice exposed to a space travel.
Autorzy :
Horie K; RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Sasanuma H; Laboratory of Developmental Genetics, Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.
Kudo T; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.; Laboratory Animal Resource Center and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.
Fujita SI; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.; Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.
Miyauchi M; RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Miyao T; RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Seki T; RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Akiyama N; RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Takakura Y; RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Shimbo M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.; Laboratory Animal Resource Center and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.
Jeon H; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.; Laboratory Animal Resource Center and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.
Shirakawa M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Ibaraki, 305-8505, Japan.
Shiba D; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Ibaraki, 305-8505, Japan.
Yoshida N; Laboratory of Developmental Genetics, Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.
Muratani M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.; Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.
Takahashi S; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.; Laboratory Animal Resource Center and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.
Akiyama T; RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan. .; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan. .
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Źródło :
Scientific reports [Sci Rep] 2019 May 21; Vol. 9 (1), pp. 7654. Date of Electronic Publication: 2019 May 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Space Flight*
Transcriptome*
GATA1 Transcription Factor/*metabolism
Spleen/*metabolism
Animals ; Down-Regulation ; Erythropoiesis ; GATA1 Transcription Factor/genetics ; Mice ; T-Cell Acute Lymphocytic Leukemia Protein 1/genetics ; T-Cell Acute Lymphocytic Leukemia Protein 1/metabolism ; Weightlessness/adverse effects
Czasopismo naukowe
Tytuł :
Hypergravity and microgravity exhibited reversal effects on the bone and muscle mass in mice.
Autorzy :
Tominari T; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan.
Ichimaru R; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan.
Taniguchi K; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan.
Yumoto A; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki, 305-8505, Japan.
Shirakawa M; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki, 305-8505, Japan.
Matsumoto C; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan.
Watanabe K; Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan.
Hirata M; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan.
Itoh Y; Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan.; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7FY, UK.
Shiba D; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki, 305-8505, Japan.
Miyaura C; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan.; Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan.
Inada M; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan. .; Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan. .
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Źródło :
Scientific reports [Sci Rep] 2019 Apr 29; Vol. 9 (1), pp. 6614. Date of Electronic Publication: 2019 Apr 29.
Typ publikacji :
Journal Article
MeSH Terms :
Cancellous Bone/*physiology
Muscle, Skeletal/*physiology
Absorptiometry, Photon ; Animals ; Body Weight/physiology ; Bone Morphogenetic Protein 2/metabolism ; Cancellous Bone/metabolism ; Eating/physiology ; Femur/metabolism ; Femur/physiology ; Humerus/metabolism ; Humerus/physiology ; Hypergravity ; Male ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal/metabolism ; MyoD Protein/metabolism ; Polymerase Chain Reaction ; RNA, Messenger/metabolism ; Sp7 Transcription Factor/metabolism ; Tibia/metabolism ; Tibia/physiology ; X-Ray Microtomography
Czasopismo naukowe
Tytuł :
Long-term hindlimb unloading causes a preferential reduction of medullary thymic epithelial cells expressing autoimmune regulator (Aire).
Autorzy :
Horie K; Center for Integrative Medical Science, RIKEN, Yokohama 230-0045, Japan; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.
Kudo T; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; Laboratory Animal Resource Center and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
Yoshinaga R; Center for Integrative Medical Science, RIKEN, Yokohama 230-0045, Japan; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.
Akiyama N; Center for Integrative Medical Science, RIKEN, Yokohama 230-0045, Japan; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.
Sasanuma H; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
Kobayashi TJ; Institute of Industrial Science, The University of Tokyo, Tokyo 153-8505, Japan.
Shimbo M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; Laboratory Animal Resource Center and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
Jeon H; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; Laboratory Animal Resource Center and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
Miyao T; Center for Integrative Medical Science, RIKEN, Yokohama 230-0045, Japan.
Miyauchi M; Center for Integrative Medical Science, RIKEN, Yokohama 230-0045, Japan.
Shirakawa M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Ibaraki 305-8505, Japan.
Shiba D; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Ibaraki 305-8505, Japan.
Yoshida N; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
Muratani M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
Takahashi S; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; Laboratory Animal Resource Center and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
Akiyama T; Center for Integrative Medical Science, RIKEN, Yokohama 230-0045, Japan; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2018 Jun 27; Vol. 501 (3), pp. 745-750.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial Cells/*cytology
Hindlimb Suspension/*methods
Thymocytes/*cytology
Thymus Gland/*physiology
Transcription Factors/*analysis
Animals ; CD4 Antigens/analysis ; CD8 Antigens/analysis ; Cell Count ; Male ; Mice, Inbred C57BL ; Organ Size ; Thymus Gland/cytology ; Time Factors
Czasopismo naukowe
Tytuł :
Long-term hindlimb unloading causes a preferential reduction of medullary thymic epithelial cells expressing autoimmune regulator (Aire).
Autorzy :
Horie, Kenta
Kudo, Takashi
Yoshinaga, Riko
Akiyama, Nobuko
Sasanuma, Hiroki
Kobayashi, Tetsuya J.
Shimbo, Miki
Jeon, Hyojung
Miyao, Takahisa
Miyauchi, Maki
Shirakawa, Masaki
Shiba, Dai
Yoshida, Nobuaki
Muratani, Masafumi
Takahashi, Satoru
Akiyama, Taishin
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Źródło :
Biochemical & Biophysical Research Communications. Jun2018, Vol. 501 Issue 3, p745-750. 6p.
Czasopismo naukowe
Tytuł :
Development of new experimental platform 'MARS'-Multiple Artificial-gravity Research System-to elucidate the impacts of micro/partial gravity on mice.
Autorzy :
Shiba D; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan. .; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan. .
Mizuno H; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Yumoto A; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Shimomura M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Kobayashi H; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Morita H; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; Department of Physiology, Gifu University Graduate School of Medicine, Gifu, Japan.
Shimbo M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.; Laboratory Animal Resource Center, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Hamada M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.; Laboratory Animal Resource Center, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Kudo T; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.; Laboratory Animal Resource Center, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Shinohara M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.; Japan Science and Technology Agency (JST), Precursory Research for Embryonic Science and Technology (PRESTO), Tokyo, Japan.
Asahara H; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Shirakawa M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan. shirakawa.masaki@jaxa.jp.; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan. shirakawa.masaki@jaxa.jp.
Takahashi S; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.; Laboratory Animal Resource Center, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.; Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
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Źródło :
Scientific reports [Sci Rep] 2017 Sep 07; Vol. 7 (1), pp. 10837. Date of Electronic Publication: 2017 Sep 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Space Flight*
Weightlessness*
Animals ; Bone and Bones/diagnostic imaging ; Bone and Bones/metabolism ; Bone and Bones/pathology ; Environment ; Male ; Mice ; Phenotype
Czasopismo naukowe
Tytuł :
Impact of a simulated gravity load for atmospheric reentry, 10 g for 2 min, on conscious mice.
Autorzy :
Morita H; Department of Physiology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan. .; Mouse Epigenetics Project, ISS/Kibo Experiment, Japan Aerospace Exploration Agency, Tsukuba, 305-8505, Japan. .
Yamaguchi A; Department of Physiology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
Shiba D; JEM Utilization Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency, Tsukuba, 305-8505, Japan.
Shirakawa M; JEM Utilization Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency, Tsukuba, 305-8505, Japan.
Takahashi S; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, 305-8575, Japan.; Mouse Epigenetics Project, ISS/Kibo Experiment, Japan Aerospace Exploration Agency, Tsukuba, 305-8505, Japan.
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Źródło :
The journal of physiological sciences : JPS [J Physiol Sci] 2017 Jul; Vol. 67 (4), pp. 531-537. Date of Electronic Publication: 2017 Feb 09.
Typ publikacji :
Journal Article
MeSH Terms :
Consciousness*
Space Flight*
Stress, Physiological*
Centrifugation/*adverse effects
Gravity, Altered/*adverse effects
Animals ; Biomarkers/blood ; Central Amygdaloid Nucleus/metabolism ; Central Amygdaloid Nucleus/physiopathology ; Centrifugation/methods ; Corticosterone/blood ; Eating ; Feeding Behavior ; Mice, Inbred C57BL ; Motion Sickness/etiology ; Motion Sickness/metabolism ; Motion Sickness/physiopathology ; Motor Activity ; Paraventricular Hypothalamic Nucleus/metabolism ; Paraventricular Hypothalamic Nucleus/physiopathology ; Proto-Oncogene Proteins c-fos/metabolism ; Time Factors ; Vestibular Nuclei/metabolism ; Vestibular Nuclei/physiopathology
Czasopismo naukowe
Tytuł :
Effects of gravity changes on gene expression of BDNF and serotonin receptors in the mouse brain.
Autorzy :
Ishikawa C; Laboratory of Neurobiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
Li H; Laboratory of Neurobiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
Ogura R; Laboratory of Neurobiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
Yoshimura Y; Laboratory of Neurobiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
Kudo T; Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.
Shirakawa M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Ibaraki, Japan.
Shiba D; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Ibaraki, Japan.
Takahashi S; Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.
Morita H; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; Department of Physiology, Gifu University Graduate School of Medicine, Gifu, Japan.
Shiga T; Laboratory of Neurobiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; Department of Neurobiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
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Źródło :
PloS one [PLoS One] 2017 Jun 07; Vol. 12 (6), pp. e0177833. Date of Electronic Publication: 2017 Jun 07 (Print Publication: 2017).
Typ publikacji :
Journal Article
MeSH Terms :
Brain-Derived Neurotrophic Factor/*biosynthesis
Receptor, Serotonin, 5-HT1A/*biosynthesis
Receptor, Serotonin, 5-HT1B/*biosynthesis
Receptor, Serotonin, 5-HT2A/*biosynthesis
Animals ; Brain/metabolism ; Brain/physiology ; Brain Mapping ; Brain-Derived Neurotrophic Factor/metabolism ; Gene Expression Regulation ; Gravitation ; Hippocampus/metabolism ; Humans ; Mice ; Receptor, Serotonin, 5-HT1A/metabolism ; Receptor, Serotonin, 5-HT1B/metabolism ; Receptor, Serotonin, 5-HT2A/metabolism ; Space Flight ; Vestibule, Labyrinth/metabolism ; Vestibule, Labyrinth/physiology
Czasopismo naukowe

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