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Tytuł:
Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice
Autorzy:
Shimizu, RitsukoAff1, Aff2, Aff3, IDs4200302305251w_cor1
Hirano, Ikuo
Hasegawa, Atsushi
Suzuki, MikikoAff2, Aff3
Otsuki, Akihito
Taguchi, KeikoAff1, Aff3
Katsuoka, FumikiAff1, Aff3
Uruno, Akira
Suzuki, Norio
Yumoto, Akane
Okada, Risa
Shirakawa, Masaki
Shiba, Dai
Takahashi, Satoru
Suzuki, Takafumi
Yamamoto, MasayukiAff1, Aff3, IDs4200302305251w_cor16
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Źródło:
Communications Biology. 6(1)
Czasopismo naukowe
Szczegóły
Tytuł:
Comparing effects of microgravity and amyotrophic lateral sclerosis in the mouse ventral lumbar spinal cord.
Autorzy:
Yoshikawa, Masaaki (AUTHOR)
Ishikawa, Chihiro (AUTHOR)
Li, Haiyan (AUTHOR)
Kudo, Takashi (AUTHOR)
Shiba, Dai (AUTHOR)
Shirakawa, Masaki (AUTHOR)
Muratani, Masafumi (AUTHOR)
Takahashi, Satoru (AUTHOR)
Aizawa, Shin (AUTHOR)
Shiga, Takashi (AUTHOR)
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Źródło:
MCN: Molecular & Cellular Neuroscience. Jul2022, Vol. 121, pN.PAG-N.PAG. 1p.
Czasopismo naukowe
Szczegóły
Tytuł:
Nrf2 plays a critical role in the metabolic response during and after spaceflight.
Autorzy:
Uruno A; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Saigusa D; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Suzuki T; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yumoto A; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Nakamura T; Department of Health Record Informatics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Matsukawa N; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Yamazaki T; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Saito R; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Taguchi K; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.; Advanced Research Center for Innovations in Next-GEneration Medicine (INGEM), Tohoku University, Sendai, Japan.
Suzuki M; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.; Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan.
Suzuki N; Division of Oxygen Biology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Otsuki A; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Katsuoka F; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.; Advanced Research Center for Innovations in Next-GEneration Medicine (INGEM), Tohoku University, Sendai, Japan.
Hishinuma E; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-GEneration Medicine (INGEM), Tohoku University, Sendai, Japan.
Okada R; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Koshiba S; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-GEneration Medicine (INGEM), Tohoku University, Sendai, Japan.
Tomioka Y; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Shimizu R; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Molecular Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shirakawa M; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Kensler TW; Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Shiba D; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan. .
Yamamoto M; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan. .; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan. .
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Źródło:
Communications biology [Commun Biol] 2021 Dec 09; Vol. 4 (1), pp. 1381. Date of Electronic Publication: 2021 Dec 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Space Flight*
Adipose Tissue, White/*metabolism
Epididymis/*metabolism
NF-E2-Related Factor 2/*genetics
Animals ; Male ; Metabolome ; Mice ; Mice, Knockout ; NF-E2-Related Factor 2/deficiency ; NF-E2-Related Factor 2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Transcriptome analysis of gravitational effects on mouse skeletal muscles under microgravity and artificial 1 g onboard environment
Autorzy:
Okada, RisaAff1, Aff2
Fujita, Shin-ichiroAff3, Aff4
Suzuki, RikuAff5, Aff6
Hayashi, TakutoAff3, Aff5
Tsubouchi, Hirona
Kato, ChihiroAff5, Aff7
Sadaki, Shunya
Kanai, MahoAff5, Aff6
Fuseya, SayakaAff3, Aff5
Inoue, YuriAff3, Aff5
Jeon, Hyojung
Hamada, Michito
Kuno, AkihiroAff5, Aff6
Ishii, Akiko
Tamaoka, Akira
Tanihata, Jun
Ito, Naoki
Shiba, DaiAff1, Aff2
Shirakawa, MasakiAff1, Aff2
Muratani, MasafumiAff1, Aff4
Kudo, TakashiAff1, Aff5
Takahashi, SatoruAff1, Aff5
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Źródło:
Scientific Reports. 11(1)
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Author Correction: Nrf2 contributes to the weight gain of mice during space travel.
Autorzy:
Suzuki T; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Uruno A; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Yumoto A; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Taguchi K; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan.
Suzuki M; Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan.
Harada N; Institute for Animal Experimentation, Tohoku University Graduate School of Medicine, Sendai, Japan.
Ryoke R; Department of Functional Brain Imaging, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
Naganuma E; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Osanai N; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Goto A; Department of Molecular Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Suda H; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Browne R; Department of Functional Brain Imaging, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
Otsuki A; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Katsuoka F; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan.
Zorzi M; Department of Molecular Biotechnology and Health Sciences, University of Turin, 10125, Torino, Italy.
Yamazaki T; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Saigusa D; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Koshiba S; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan.
Nakamura T; Division of Molecular Pharmacology & Cell Biophysics, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Fukumoto S; Division of Pediatric Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Ikehata H; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Nishikawa K; Immunology Frontier Research Center, Osaka University, Suita, Japan.
Suzuki N; Division of Oxygen Biology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hirano I; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Molecular Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shimizu R; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Molecular Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Oishi T; Division of Oxygen Biology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Motohashi H; Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Tsubouchi H; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Okada R; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Kudo T; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Shimomura M; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Kensler TW; Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Mizuno H; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Shirakawa M; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Takahashi S; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Shiba D; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan. .
Yamamoto M; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan. .; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan. .; The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan. .
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Źródło:
Communications biology [Commun Biol] 2020 Oct 07; Vol. 3 (1), pp. 566. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji:
Published Erratum
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight.
Autorzy:
Horie K; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Kato T; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Kudo T; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.
Sasanuma H; Laboratory of Developmental Genetics, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
Miyauchi M; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Akiyama N; Laboratory for Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Miyao T; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Seki T; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Ishikawa T; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Takakura Y; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Shirakawa M; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Ibaraki, 305-8505, Japan.
Shiba D; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Ibaraki, 305-8505, Japan.
Hamada M; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.
Jeon H; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.
Yoshida N; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.; Laboratory of Developmental Genetics, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
Inoue JI; Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
Muratani M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.; Transborder Medical Research Center, and Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.
Takahashi S; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.
Ohno H; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan. .
Akiyama T; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan. .; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2019 Dec 27; Vol. 9 (1), pp. 19866. Date of Electronic Publication: 2019 Dec 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gravity, Altered*
Space Flight*
Thymus Gland/*metabolism
Animals ; Base Sequence ; Enzyme-Linked Immunosorbent Assay ; Male ; Mice ; Mice, Inbred C57BL ; Principal Component Analysis ; RNA-Seq
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dietary intervention of mice using an improved Multiple Artificial-gravity Research System (MARS) under artificial 1 g
Autorzy:
Matsuda, Chie
Kato, TamotsuAff2, Aff3
Inoue-Suzuki, SayoAff4, Aff2
Kikuchi, JunAff5, Aff3
Ohta, ToshikoAff1, Aff2, Aff4
Kagawa, Masaharu
Hattori, MasahiraAff2, Aff6
Kobayashi, Hiroe
Shiba, Dai
Shirakawa, Masaki
Mizuno, Hiroyasu
Furukawa, Satoshi
Mukai, Chiaki
Ohno, HiroshiAff2, Aff3
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Źródło:
npj Microgravity. 5(1)
Czasopismo naukowe
Szczegóły
Tytuł:
Down-regulation of GATA1-dependent erythrocyte-related genes in the spleens of mice exposed to a space travel
Autorzy:
Horie, Kenta
Sasanuma, HirokiAff2, Aff3
Kudo, TakashiAff3, Aff4
Fujita, Shin-ichiroAff3, Aff5
Miyauchi, Maki
Miyao, Takahisa
Seki, Takao
Akiyama, Nobuko
Takakura, Yuki
Shimbo, MikiAff3, Aff4
Jeon, HyojungAff3, Aff4
Shirakawa, MasakiAff3, Aff6
Shiba, DaiAff3, Aff6
Yoshida, NobuakiAff2, Aff3
Muratani, MasafumiAff3, Aff5
Takahashi, SatoruAff3, Aff4
Akiyama, TaishinAff1, Aff3
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Źródło:
Scientific Reports. 9(1)
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hypergravity and microgravity exhibited reversal effects on the bone and muscle mass in mice.
Autorzy:
Tominari T; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan.
Ichimaru R; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan.
Taniguchi K; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan.
Yumoto A; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki, 305-8505, Japan.
Shirakawa M; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki, 305-8505, Japan.
Matsumoto C; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan.
Watanabe K; Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan.
Hirata M; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan.
Itoh Y; Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan.; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7FY, UK.
Shiba D; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, 2-1-1 Sengen, Tsukuba, Ibaraki, 305-8505, Japan.
Miyaura C; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan.; Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan.
Inada M; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan. .; Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo, 184-8588, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2019 Apr 29; Vol. 9 (1), pp. 6614. Date of Electronic Publication: 2019 Apr 29.
Typ publikacji:
Journal Article
MeSH Terms:
Cancellous Bone/*physiology
Muscle, Skeletal/*physiology
Absorptiometry, Photon ; Animals ; Body Weight/physiology ; Bone Morphogenetic Protein 2/metabolism ; Cancellous Bone/metabolism ; Eating/physiology ; Femur/metabolism ; Femur/physiology ; Humerus/metabolism ; Humerus/physiology ; Hypergravity ; Male ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal/metabolism ; MyoD Protein/metabolism ; Polymerase Chain Reaction ; RNA, Messenger/metabolism ; Sp7 Transcription Factor/metabolism ; Tibia/metabolism ; Tibia/physiology ; X-Ray Microtomography
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic Analysis.
Autorzy:
Mao, Xiao W.
Byrum, Stephanie
Nishiyama, Nina C.
Pecaut, Michael J.
Sridharan, Vijayalakshmi
Boerma, Marjan
Tackett, Alan J.
Shiba, Dai
Shirakawa, Masaki shirakawa.masaki@jaxa.jp
Takahashi, Satoru
Delp, Michael D.
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Źródło:
International Journal of Molecular Sciences. Sep2018, Vol. 19 Issue 9, p2546. 1p. 6 Diagrams, 3 Charts, 2 Graphs.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Long-term hindlimb unloading causes a preferential reduction of medullary thymic epithelial cells expressing autoimmune regulator (Aire).
Autorzy:
Horie, Kenta
Kudo, Takashi
Yoshinaga, Riko
Akiyama, Nobuko
Sasanuma, Hiroki
Kobayashi, Tetsuya J.
Shimbo, Miki
Jeon, Hyojung
Miyao, Takahisa
Miyauchi, Maki
Shirakawa, Masaki
Shiba, Dai
Yoshida, Nobuaki
Muratani, Masafumi
Takahashi, Satoru
Akiyama, Taishin
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Źródło:
Biochemical & Biophysical Research Communications. Jun2018, Vol. 501 Issue 3, p745-750. 6p.
Czasopismo naukowe
Szczegóły
Tytuł:
Effects of gravity changes on gene expression of BDNF and serotonin receptors in the mouse brain.
Autorzy:
Ishikawa C; Laboratory of Neurobiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
Li H; Laboratory of Neurobiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
Ogura R; Laboratory of Neurobiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
Yoshimura Y; Laboratory of Neurobiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
Kudo T; Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.
Shirakawa M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Ibaraki, Japan.
Shiba D; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Ibaraki, Japan.
Takahashi S; Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.
Morita H; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; Department of Physiology, Gifu University Graduate School of Medicine, Gifu, Japan.
Shiga T; Laboratory of Neurobiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.; Department of Neurobiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
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Źródło:
PloS one [PLoS One] 2017 Jun 07; Vol. 12 (6), pp. e0177833. Date of Electronic Publication: 2017 Jun 07 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Brain-Derived Neurotrophic Factor/*biosynthesis
Receptor, Serotonin, 5-HT1A/*biosynthesis
Receptor, Serotonin, 5-HT1B/*biosynthesis
Receptor, Serotonin, 5-HT2A/*biosynthesis
Animals ; Brain/metabolism ; Brain/physiology ; Brain Mapping ; Brain-Derived Neurotrophic Factor/metabolism ; Gene Expression Regulation ; Gravitation ; Hippocampus/metabolism ; Humans ; Mice ; Receptor, Serotonin, 5-HT1A/metabolism ; Receptor, Serotonin, 5-HT1B/metabolism ; Receptor, Serotonin, 5-HT2A/metabolism ; Space Flight ; Vestibule, Labyrinth/metabolism ; Vestibule, Labyrinth/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Acute transcriptional up-regulation specific to osteoblasts/osteoclasts in medaka fish immediately after exposure to microgravity.
Autorzy:
Chatani, Masahiro
Morimoto, Hiroya
Takeyama, Kazuhiro
Mantoku, Akiko
Tanigawa, Naoki
Kubota, Koji
Suzuki, Hiromi
Uchida, Satoko
Tanigaki, Fumiaki
Shirakawa, Masaki
Gusev, Oleg
Sychev, Vladimir
Takano, Yoshiro
Itoh, Takehiko
Kudo, Akira
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Źródło:
Scientific Reports; 12/23/2016, p39545, 1p
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Hypergravity Provokes a Temporary Reduction in CD4+CD8+ Thymocyte Number and a Persistent Decrease in Medullary Thymic Epithelial Cell Frequency in Mice.
Autorzy:
Tateishi R; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan.
Akiyama N; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan.
Miyauchi M; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan.
Yoshinaga R; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan.
Sasanuma H; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The University of Tokyo, Tokyo, Japan.
Kudo T; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki, Japan; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Shimbo M; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki, Japan; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Shinohara M; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan; JST, PRESTO, Kawaguchi, Saitama, Japan.
Obata K; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; Department of Physiology, Gifu University Graduate School of Medicine, Gifu, Japan.
Inoue J; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Shirakawa M; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Ibaraki, Japan.
Shiba D; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Ibaraki, Japan.
Asahara H; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Yoshida N; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The University of Tokyo, Tokyo, Japan.
Takahashi S; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki, Japan; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Morita H; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; Department of Physiology, Gifu University Graduate School of Medicine, Gifu, Japan.
Akiyama T; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan.
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Źródło:
PloS one [PLoS One] 2015 Oct 29; Vol. 10 (10), pp. e0141650. Date of Electronic Publication: 2015 Oct 29 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Count*
Hypergravity*
Epithelial Cells/*metabolism
T-Lymphocyte Subsets/*metabolism
Thymocytes/*metabolism
Thymus Gland/*cytology
Thymus Gland/*metabolism
Animals ; Biomarkers ; CD4 Antigens/metabolism ; CD8 Antigens/metabolism ; Gene Expression ; Immunophenotyping ; Mice ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptor Activator of Nuclear Factor-kappa B/genetics ; Receptor Activator of Nuclear Factor-kappa B/metabolism ; Time Factors
Czasopismo naukowe
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Wyświetlanie 1-20 z 80

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