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Tytuł :
Preclinical evaluation of cancer immune therapy using patient-derived tumor antigen-specific T cells in a novel xenograft platform.
Autorzy :
Shenoy GN; Department of Microbiology and Immunology at the Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA.
Greene CJ; Department of Microbiology and Immunology at the Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA.; Present address: Hodgson Russ LLP. Buffalo NY USA.
Bhatta M; Immune Modulatory Therapies, LLC Eden NY USA.; Present address: Roswell Park Comprehensive Cancer Center Buffalo NY USA.
Baroja ML; Center for Cellular Immunotherapies Perelman School of Medicine University of Pennsylvania Philadelphia PA USA.
Loyall JL; Department of Microbiology and Immunology at the Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA.
Balu-Iyer SV; Department of Pharmaceutical Sciences University at Buffalo Buffalo NY USA.
Kelleher RJ Jr; Department of Microbiology and Immunology at the Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA.
Carreno BM; Center for Cellular Immunotherapies Perelman School of Medicine University of Pennsylvania Philadelphia PA USA.
Linette GP; Center for Cellular Immunotherapies Perelman School of Medicine University of Pennsylvania Philadelphia PA USA.
Shultz LD; The Jackson Laboratory Bar Harbor ME USA.
Bankert RB; Department of Microbiology and Immunology at the Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA.
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Źródło :
Clinical & translational immunology [Clin Transl Immunology] 2021 Feb 02; Vol. 10 (2), pp. e1246. Date of Electronic Publication: 2021 Feb 02 (Print Publication: 2021).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia.
Autorzy :
de Groot AP; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Saito Y; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Kawakami E; Healthcare and Medical Data Driven AI based Predictive Reasoning Development Unit, RIKEN Medical Sciences Innovation Hub Program, Yokohama, Japan.
Hashimoto M; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Aoki Y; Department of Pediatrics, National Cancer Center Hospital, Tokyo, Japan.
Ono R; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Ogahara I; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Fujiki S; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Kaneko A; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Sato K; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Kajita H; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Watanabe T; Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Takagi M; Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan.
Tomizawa D; Division of Leukaemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Koh K; Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.
Eguchi M; Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan.
Ishii E; Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan.
Ohara O; Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Kazusa DNA Research Institute, Kisarazu, Chiba, Japan.
Shultz LD; The Jackson Laboratory, Bar Harbor, USA.
Mizutani S; Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan.
Ishikawa F; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. Electronic address: .
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Źródło :
EBioMedicine [EBioMedicine] 2021 Feb; Vol. 64, pp. 103235. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy.
Autorzy :
Jiang L; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Wang YJ; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Zhao J; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Uehara M; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Hou Q; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao 266071, China.
Kasinath V; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ichimura T; Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Banouni N; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Dai L; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Li X; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Greiner DL; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Shultz LD; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Zhang X; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
Sun ZJ; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Curtin I; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Vangos NE; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Yeoh ZC; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Geffken EA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Seo HS; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Liu ZX; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
Heffron GJ; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.
Shah K; Center for Stem Cell Therapeutics and Imaging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Dhe-Paganon S; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Abdi R; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: .
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Źródło :
Cell [Cell] 2020 Nov 25; Vol. 183 (5), pp. 1219-1233.e18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cytotoxicity, Immunologic*/drug effects
Immunotherapy*
Membrane Proteins/*metabolism
Neoplasms/*immunology
Neoplasms/*therapy
Serpins/*metabolism
Animals ; Apoptosis/drug effects ; Breast Neoplasms/immunology ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Disease Progression ; Female ; Gene Deletion ; Granzymes/metabolism ; Immunity/drug effects ; Melanoma/pathology ; Mice, Inbred C57BL ; Neoplasms/prevention & control ; Small Molecule Libraries/pharmacology ; Stromal Cells/drug effects ; Stromal Cells/pathology ; Tumor Microenvironment/drug effects
Czasopismo naukowe
Tytuł :
Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis.
Autorzy :
Li P; The Jackson Laboratory, Bar Harbor, ME, USA.; Key Laboratory of Experimental Teratology, Ministry of Education and Department of Molecular Medicine and Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
Lu M; The Jackson Laboratory, Bar Harbor, ME, USA.; Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, Shanghai, China.
Shi J; The Jackson Laboratory, Bar Harbor, ME, USA.
Gong Z; The Jackson Laboratory, Bar Harbor, ME, USA.
Hua L; The Jackson Laboratory, Bar Harbor, ME, USA.
Li Q; The Jackson Laboratory, Bar Harbor, ME, USA.
Lim B; Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Zhang XH; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Chen X; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Li S; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; The Jackson Laboratory Cancer Center, Bar Harbor, ME, USA.; Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT, USA.; Department of Computer Science and Engineering, University of Connecticut, Storrs, CT, USA.
Shultz LD; The Jackson Laboratory, Bar Harbor, ME, USA.; The Jackson Laboratory Cancer Center, Bar Harbor, ME, USA.
Ren G; The Jackson Laboratory, Bar Harbor, ME, USA. .; The Jackson Laboratory Cancer Center, Bar Harbor, ME, USA. .
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Źródło :
Nature immunology [Nat Immunol] 2020 Nov; Vol. 21 (11), pp. 1444-1455. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Lipid Metabolism*
Breast Neoplasms/*metabolism
Breast Neoplasms/*pathology
Lung Neoplasms/*metabolism
Lung Neoplasms/*secondary
Mesenchymal Stem Cells/*metabolism
Neutrophils/*metabolism
Animals ; Biomarkers ; Cell Proliferation ; Disease Progression ; Endocytosis ; Female ; Fluorescent Antibody Technique ; Humans ; Mice ; Neoplasm Metastasis ; Neutrophils/ultrastructure
Czasopismo naukowe
Tytuł :
Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status.
Autorzy :
Li P; Key Laboratory of Experimental Teratology, Ministry of Education and Department of Molecular Medicine and Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, 250012, Jinan, Shandong, China.; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Lu M; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.; Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 200040, Shanghai, China.
Shi J; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Hua L; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Gong Z; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Li Q; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Shultz LD; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Ren G; The Jackson Laboratory, Bar Harbor, ME, 04609, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Sep 01; Vol. 11 (1), pp. 4387. Date of Electronic Publication: 2020 Sep 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Killer Cells, Natural/*immunology
Lung Neoplasms/*immunology
Mammary Neoplasms, Animal/*immunology
Neutropenia/*prevention & control
Neutrophils/*immunology
Animals ; Cell Line, Tumor/transplantation ; Coculture Techniques ; Disease Models, Animal ; Female ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Granulocyte Colony-Stimulating Factor/adverse effects ; Humans ; Injections, Intravenous ; Lung/cytology ; Lung/immunology ; Lung/pathology ; Lung Neoplasms/blood ; Lung Neoplasms/secondary ; Mammary Glands, Animal/cytology ; Mammary Glands, Animal/immunology ; Mammary Glands, Animal/pathology ; Mammary Neoplasms, Animal/blood ; Mammary Neoplasms, Animal/complications ; Mammary Neoplasms, Animal/pathology ; Mice ; Mice, Inbred NOD ; Neutropenia/blood ; Neutropenia/etiology ; Neutropenia/immunology ; Neutrophils/drug effects ; Primary Cell Culture
Czasopismo naukowe
Tytuł :
A rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic-related cytokine release syndrome.
Autorzy :
Ye C; The Jackson Laboratory, Sacramento, CA, USA.
Yang H; The Jackson Laboratory, Sacramento, CA, USA.
Cheng M; The Jackson Laboratory, Sacramento, CA, USA.
Shultz LD; The Jackson Laboratory, Bar Harbor, MA, USA.
Greiner DL; Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA.
Brehm MA; Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA.
Keck JG; The Jackson Laboratory, Sacramento, CA, USA.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Sep; Vol. 34 (9), pp. 12963-12975. Date of Electronic Publication: 2020 Aug 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Disease Models, Animal*
Antibodies, Monoclonal/*adverse effects
Cytokine Release Syndrome/*immunology
Cytokines/*immunology
Leukocytes, Mononuclear/*immunology
Animals ; Antibodies, Monoclonal/immunology ; Cytokine Release Syndrome/chemically induced ; Female ; Mice ; Mice, Inbred NOD ; Mice, SCID
Czasopismo naukowe
Tytuł :
Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice.
Autorzy :
Saito Y; RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, 230-0045, Japan.
Shultz LD; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Ishikawa F; RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, 230-0045, Japan. Electronic address: .
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Źródło :
Trends in immunology [Trends Immunol] 2020 Aug; Vol. 41 (8), pp. 706-720. Date of Electronic Publication: 2020 Jul 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Hematopoiesis*/immunology
Precision Medicine*/trends
Animals ; Disease Models, Animal ; Humans
Czasopismo naukowe
Tytuł :
Dapagliflozin Does Not Directly Affect Human α or β Cells.
Autorzy :
Dai C; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Walker JT; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee.
Shostak A; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Bouchi Y; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Poffenberger G; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Hart NJ; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Jacobson DA; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee.
Calcutt MW; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee.
Bottino R; Institute of Cellular Therapeutics, Allegheny-Singer Research Institute, Allegheny Health Network, Pittsburgh, Pennsylvania.
Greiner DL; Department of Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts.
Shultz LD; The Jackson Laboratory, Bar Harbor, Maine.
McGuinness OP; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee.
Dean ED; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee.
Powers AC; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee.; VA Tennessee Valley Healthcare System, Nashville Tennessee.
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Źródło :
Endocrinology [Endocrinology] 2020 Aug 01; Vol. 161 (8).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Benzhydryl Compounds/*pharmacology
Glucagon-Secreting Cells/*drug effects
Glucosides/*pharmacology
Insulin-Secreting Cells/*drug effects
Adolescent ; Adult ; Animals ; Cells, Cultured ; Female ; Glucagon/metabolism ; Glucagon-Secreting Cells/metabolism ; Heterografts ; Humans ; Insulin/metabolism ; Insulin Secretion/drug effects ; Insulin-Secreting Cells/metabolism ; Islets of Langerhans/drug effects ; Islets of Langerhans/metabolism ; Islets of Langerhans/physiology ; Male ; Mice ; Mice, Inbred NOD ; Mice, Transgenic ; Middle Aged ; Signal Transduction/drug effects ; Species Specificity ; Young Adult
Czasopismo naukowe
Tytuł :
Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation.
Autorzy :
Hosur V; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA. .
Low BE; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.
Li D; Arthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Cornell Medicine, New York, NY, 10021, USA.
Stafford GA; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.
Kohar V; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.
Shultz LD; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.
Wiles MV; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA. .
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Źródło :
Genome biology [Genome Biol] 2020 Jul 09; Vol. 21 (1), pp. 168. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Czasopismo naukowe
Tytuł :
TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice.
Autorzy :
Johanna I; Department of Hematology and Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
Hernández-López P; Department of Hematology and Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
Heijhuurs S; Department of Hematology and Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
Bongiovanni L; Department of Pathobiology, Dutch Molecular Pathology Center, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
de Bruin A; Department of Pathobiology, Dutch Molecular Pathology Center, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Beringer D; Department of Hematology and Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
van Dooremalen S; Department of Hematology and Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
Shultz LD; Department of Immunology, The Jackson Laboratory, Bar Harbor, Maine, USA.
Ishikawa F; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Sebestyen Z; Department of Hematology and Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
Straetemans T; Department of Hematology and Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
Kuball J; Department of Hematology and Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2020 Jun; Vol. 107 (6), pp. 1069-1079. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
HLA-A24 Antigen/*genetics
Receptors, Antigen, T-Cell, gamma-delta/*genetics
Soft Tissue Neoplasms/*prevention & control
T-Lymphocytes, Regulatory/*immunology
Adoptive Transfer ; Animals ; Cell Engineering ; Gene Expression ; Graft vs Host Disease/genetics ; Graft vs Host Disease/immunology ; Graft vs Host Disease/prevention & control ; HLA-A24 Antigen/immunology ; Humans ; Immunotherapy/methods ; K562 Cells ; Male ; Mice ; Mice, Transgenic ; Receptors, Antigen, T-Cell, gamma-delta/immunology ; Signal Transduction ; Soft Tissue Neoplasms/genetics ; Soft Tissue Neoplasms/immunology ; Soft Tissue Neoplasms/pathology ; T-Lymphocytes, Regulatory/pathology ; T-Lymphocytes, Regulatory/transplantation ; Transduction, Genetic ; Whole-Body Irradiation
Czasopismo naukowe
Tytuł :
Improved mouse models and advanced genetic and genomic technologies for the study of neutrophils.
Autorzy :
Hosur V; The Jackson Laboratory for Mammalian Genetics, 600 Main Street, Bar Harbor, ME 04609 USA. Electronic address: .
Skelly DA; The Jackson Laboratory for Mammalian Genetics, 600 Main Street, Bar Harbor, ME 04609 USA.
Francis C; Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 360 Huntington Avenue, Boston, MA 02115 USA.
Low BE; The Jackson Laboratory for Mammalian Genetics, 600 Main Street, Bar Harbor, ME 04609 USA.
Kohar V; The Jackson Laboratory for Mammalian Genetics, 600 Main Street, Bar Harbor, ME 04609 USA.
Burzenski LM; The Jackson Laboratory for Mammalian Genetics, 600 Main Street, Bar Harbor, ME 04609 USA.
Amiji MM; Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 360 Huntington Avenue, Boston, MA 02115 USA.
Shultz LD; The Jackson Laboratory for Mammalian Genetics, 600 Main Street, Bar Harbor, ME 04609 USA.
Wiles MV; The Jackson Laboratory for Mammalian Genetics, 600 Main Street, Bar Harbor, ME 04609 USA.
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Źródło :
Drug discovery today [Drug Discov Today] 2020 Jun; Vol. 25 (6), pp. 1013-1025. Date of Electronic Publication: 2020 May 05.
Typ publikacji :
Journal Article; Review; Research Support, N.I.H., Extramural
Czasopismo naukowe
Tytuł :
Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable.
Autorzy :
Dai C; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, and.
Walker JT; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Shostak A; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, and.
Padgett A; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, and.
Spears E; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, and.
Wisniewski S; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, and.
Poffenberger G; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, and.
Aramandla R; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, and.
Dean ED; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, and.
Prasad N; HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA.
Levy SE; HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA.
Greiner DL; Department of Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Shultz LD; The Jackson Laboratory, Bar Harbor, Maine, USA.
Bottino R; Institute of Cellular Therapeutics, Allegheny-Singer Research Institute, Allegheny Health Network, Pittsburgh, Pennsylvania, USA.
Powers AC; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, and.; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; VA Tennessee Valley Healthcare System, Nashville, Tennessee, USA.
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Źródło :
JCI insight [JCI Insight] 2020 Jan 16; Vol. 5 (1). Date of Electronic Publication: 2020 Jan 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Insulin-Secreting Cells/*drug effects
Insulin-Secreting Cells/*metabolism
Sirolimus/*pharmacology
Tacrolimus/*pharmacology
Animals ; Calcineurin/metabolism ; Diabetes Mellitus ; Graft Rejection ; Humans ; Immunosuppressive Agents/pharmacology ; Insulin/metabolism ; Islets of Langerhans/drug effects ; Islets of Langerhans Transplantation ; Male ; Mice ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/drug effects
Czasopismo naukowe
Tytuł :
Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice.
Autorzy :
Redick SD; Diabetes Center of Excellence, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Leehy L; Diabetes Center of Excellence, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Rittenhouse AR; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.
Blodgett DM; Diabetes Center of Excellence, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.; Math and Science Division, Babson College, Wellesley, MA, USA.
Derr AG; Diabetes Center of Excellence, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA.
Kucukural A; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA.
Garber MG; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA.
Shultz LD; The Jackson Laboratory, Bar Harbor, ME, USA.
Greiner DL; Diabetes Center of Excellence, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Wang JP; Diabetes Center of Excellence, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Harlan DM; Diabetes Center of Excellence, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Bortell R; Diabetes Center of Excellence, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Jurczyk A; Diabetes Center of Excellence, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Jan; Vol. 34 (1), pp. 1901-1911. Date of Electronic Publication: 2019 Dec 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Endocrine Cells/*physiology
Islets of Langerhans/*physiology
Transcriptome/*physiology
Adult ; Animals ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Endocrine Cells/metabolism ; Female ; Gene Expression Profiling/methods ; Graft Survival/physiology ; Humans ; Insulin/metabolism ; Insulin-Secreting Cells/metabolism ; Insulin-Secreting Cells/physiology ; Islets of Langerhans/metabolism ; Islets of Langerhans Transplantation/methods ; Male ; Mice ; Transplantation, Heterologous/methods ; Young Adult
Czasopismo naukowe
Tytuł :
Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain.
Autorzy :
Svoboda DS; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
Barrasa MI; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.; Bioinformatics and Research Computing, Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
Shu J; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.; Broad Institute of MIT and Harvard, Cambridge, MA 02142.
Rietjens R; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
Zhang S; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
Mitalipova M; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
Berube P; Broad Institute of MIT and Harvard, Cambridge, MA 02142.
Fu D; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
Shultz LD; The Jackson Laboratory Cancer Center, The Jackson Laboratory, Bar Harbor, ME 04609.
Bell GW; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.; Bioinformatics and Research Computing, Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
Jaenisch R; Whitehead Institute for Biomedical Research, Cambridge, MA 02142; .; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Dec 10; Vol. 116 (50), pp. 25293-25303. Date of Electronic Publication: 2019 Nov 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*physiology
Induced Pluripotent Stem Cells/*transplantation
Microglia/*transplantation
Animals ; Brain/metabolism ; Brain/surgery ; Gene Expression ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Mice ; Microglia/metabolism ; Phenotype
Czasopismo naukowe
Tytuł :
Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells.
Autorzy :
Wagenblast E; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.
Azkanaz M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.
Smith SA; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.
Shakib L; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.
McLeod JL; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.
Krivdova G; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.
Araújo J; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.
Shultz LD; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Gan OI; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.
Dick JE; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada. .; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada. .
Lechman ER; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada. .
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Źródło :
Nature communications [Nat Commun] 2019 Oct 18; Vol. 10 (1), pp. 4730. Date of Electronic Publication: 2019 Oct 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CRISPR-Cas Systems*
Cell Differentiation/*genetics
Cell Proliferation/*genetics
Gene Editing/*methods
Hematopoietic Stem Cells/*metabolism
Animals ; Electroporation/methods ; Female ; GATA1 Transcription Factor/genetics ; GATA1 Transcription Factor/metabolism ; Hematopoietic Stem Cells/cytology ; Humans ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
Genome-wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice Reveals Key Virulence Features.
Autorzy :
Karlinsey JE; Department of Microbiology, University of Washington, Seattle, WA 98195, USA.
Stepien TA; Department of Global Health, University of Washington, Seattle, WA 98195, USA.
Mayho M; Quadram Institute Bioscience, Norwich, UK.
Singletary LA; Department of Microbiology, University of Washington, Seattle, WA 98195, USA.
Bingham-Ramos LK; Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
Brehm MA; Program in Molecular Medicine and the Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Greiner DL; Program in Molecular Medicine and the Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Shultz LD; Jackson Laboratory, Bar Harbor, ME 04609, USA.
Gallagher LA; Department of Genome Sciences, School of Medicine, University of Washington, Seattle, WA 98195, USA.
Bawn M; Quadram Institute Bioscience, Norwich, UK; Earlham Institute, Norwich, UK.
Kingsley RA; Quadram Institute Bioscience, Norwich, UK; School of Biological Science, University of East Anglia, Norwich, UK.
Libby SJ; Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
Fang FC; Department of Microbiology, University of Washington, Seattle, WA 98195, USA; Department of Global Health, University of Washington, Seattle, WA 98195, USA; Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2019 Sep 11; Vol. 26 (3), pp. 426-434.e6. Date of Electronic Publication: 2019 Aug 22.
Typ publikacji :
Journal Article
MeSH Terms :
Genome-Wide Association Study/*methods
Salmonella Infections/*metabolism
Salmonella Infections/*microbiology
Salmonella typhi/*genetics
Salmonella typhi/*pathogenicity
Amino Acids, Aromatic/biosynthesis ; Animals ; Bacterial Proteins/genetics ; Bacterial Toxins/genetics ; DNA-Activated Protein Kinase/genetics ; DNA-Binding Proteins/genetics ; Disease Models, Animal ; Genomic Islands/genetics ; Humans ; Interleukin Receptor Common gamma Subunit/genetics ; Iron/metabolism ; Lipopolysaccharides/metabolism ; Membrane Proteins/genetics ; Mice ; Mice, Inbred NOD ; Mice, Obese ; Mice, SCID ; Salmonella typhi/growth & development ; Siderophores/metabolism ; THP-1 Cells/microbiology ; Typhoid Fever ; Virulence/genetics
Czasopismo naukowe
Tytuł :
Mesenchymal stem cells: From regeneration to cancer.
Autorzy :
Li P; The Key Laboratory of Experimental Teratology of the Ministry of Education, School of Basic Medical Science, Shandong University, Jinan, Shandong 250012, China; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Gong Z; The Key Laboratory of Experimental Teratology of the Ministry of Education, School of Basic Medical Science, Shandong University, Jinan, Shandong 250012, China; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Shultz LD; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Ren G; The Jackson Laboratory, Bar Harbor, ME 04609, USA. Electronic address: .
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Źródło :
Pharmacology & therapeutics [Pharmacol Ther] 2019 Aug; Vol. 200, pp. 42-54. Date of Electronic Publication: 2019 Apr 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Neoplasms*
Regeneration*
Mesenchymal Stem Cells/*physiology
Animals ; Carcinogenesis ; Humans ; Wound Healing
Czasopismo naukowe
Tytuł :
Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop.
Autorzy :
Bedognetti D; Sidra Medicine, Doha, Qatar.
Ceccarelli M; AbbVie, Redwood City, CA, USA.
Galluzzi L; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, New York, NY, USA.; Université Paris Descartes/Paris V, Paris, France.
Lu R; AbbVie, Redwood City, CA, USA.
Palucka K; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Samayoa J; AbbVie, Redwood City, CA, USA.
Spranger S; Koch Institute for Integrative Cancer Research at MIT, Cambridge, MT, USA.
Warren S; NanoString Technologies, Inc, Seattle, WA, USA.
Wong KK; Perlmutter Cancer Center, New York Langone Health, New York, NY, USA.
Ziv E; University of California, San Francisco, CA, USA.
Chowell D; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Coussens LM; Oregon Health & Science University, Portland, OR, USA.
De Carvalho DD; Department of Medical Biophysics, Princess Margaret Cancer Centre University Health Network, University of Toronto, Toronto, Canada.
DeNardo DG; Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Galon J; INSERM, Laboratory of Integrative Cancer Immunology, Equipe Labellisée Ligue Contre le Cancer, Sorbonne Université, Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot; Centre de Recherche des Cordeliers, F-75006, Paris, France.
Kaufman HL; Massachusetts General Hospital, Boston, MA, USA and Replimune, Inc, Woburn, MA, USA.
Kirchhoff T; Perlmutter Comprehensive Cancer Center, New York University School of Medicine, New York University Langone Health New York, New York, NY, USA.
Lotze MT; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Luke JJ; University of Chicago, Chicago, IL, USA.
Minn AJ; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA.
Politi K; Yale School of Medicine, New Haven, CT, USA.
Shultz LD; The Jackson Laboratory Cancer Center, Bar Harbor, ME, USA.
Simon R; R. Simon Consulting, Potomac, MD, USA.
Thórsson V; Institute for Systems Biology, Seattle, WA, USA.
Weidhaas JB; University of California, Los Angeles, Los Angeles, CA, USA.
Ascierto ML; MedImmune, Gaithersberg, MD, USA.
Ascierto PA; Istituto Nazionale Tumori-IRCCS Fondazione 'G. Pascale', Naples, Italy.
Barnes JM; AbbVie, Redwood City, CA, USA.
Barsan V; Stanford University, Stanford, CA, USA.
Bommareddy PK; Rutgers University, New Brunswick, NJ, USA.
Bot A; Kite, a Gilead Company, Santa Monica, CA, USA.
Church SE; NanoString Technologies, Inc, Seattle, WA, USA.
Ciliberto G; IRCCS Istituto Nazionale Tumori Regina Elena, Rome, Italy.
De Maria A; Università degli Studi di Genova and Ospedale Policlinico San Martino IRCCS, Genoa, Italy.
Draganov D; Calidi Biotherapeutics, San Diego, CA, USA.
Ho WS; Department of Neurosurgery, Division of Pediatric Neurosurgery, Primary Children's Hospital, University of Utah, Salt Lake City, UT, USA.
McGee HM; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Monette A; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
Murphy JF; Caprion Biosciences Inc, Montreal, QC, Canada.
Nisticò P; IRCCS Istituto Nazionale Tumori Regina Elena, Rome, Italy.
Park W; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Patel M; AbbVie, Redwood City, CA, USA.
Quigley M; Bristol-Myers Squibb Company, Redwood City, CA, USA.
Radvanyi L; Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Raftopoulos H; Bayer HealthCare Pharmaceuticals Inc, Whippany, NJ, USA.
Rudqvist NP; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Snyder A; Merck & Co, Kenilworth, NJ, USA.
Sweis RF; University of Chicago, Chicago, IL, USA.
Valpione S; CRUK Manchester Institute and The Christie NHS Foundation Trust, The University of Manchester, Manchester, UK.
Zappasodi R; Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Butterfield LH; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.
Disis ML; University of Washington, Seattle, WA, USA.
Fox BA; Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, USA.
Cesano A; NanoString Technologies, Inc, Seattle, WA, USA.
Marincola FM; Refuge Biotechnologies Inc, 1505 Adams Drive, Suite D, Menlo Park, CA, 94025, USA. .
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Corporate Authors :
Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups
Źródło :
Journal for immunotherapy of cancer [J Immunother Cancer] 2019 Jul 04; Vol. 7 (1), pp. 167. Date of Electronic Publication: 2019 Jul 04.
Typ publikacji :
Published Erratum
Tytuł :
Humanized immune system mouse models: progress, challenges and opportunities.
Autorzy :
Allen TM; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Brehm MA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Bridges S; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, National Institutes of Health, Rockville, MD, USA.
Ferguson S; Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Kumar P; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA.
Mirochnitchenko O; Office of Research Infrastructure Programs, Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, National Institutes of Health, Bethesda, MD, USA.
Palucka K; The Jackson Laboratory, Farmington, CT, USA.
Pelanda R; Department of Immunology and Microbiology, University of Colorado, Aurora, CO, USA.
Sanders-Beer B; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, National Institutes of Health, Rockville, MD, USA.
Shultz LD; The Jackson Laboratory, Bar Harbor, ME, USA.
Su L; University of North Carolina, Chapel Hill, Chapel Hill, NC, USA.
PrabhuDas M; Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA. .
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Źródło :
Nature immunology [Nat Immunol] 2019 Jul; Vol. 20 (7), pp. 770-774.
Typ publikacji :
Congress; Letter
MeSH Terms :
Immune System*
Mice, Transgenic*
Models, Animal*
Animals ; Disease Models, Animal ; Humans ; Mice
Opinia redakcyjna
Tytuł :
Humanized mouse models of immunological diseases and precision medicine.
Autorzy :
Shultz LD; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA. lenny.shultz@jax.org.
Keck J; The Jackson Laboratory, 1650 Santa Ana Avenue, Sacramento, CA, 95838, USA.
Burzenski L; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA.
Jangalwe S; Diabetes Center of Excellence, The University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
Vaidya S; Diabetes Center of Excellence, The University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
Greiner DL; Diabetes Center of Excellence, The University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
Brehm MA; Diabetes Center of Excellence, The University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
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Źródło :
Mammalian genome : official journal of the International Mammalian Genome Society [Mamm Genome] 2019 Jun; Vol. 30 (5-6), pp. 123-142. Date of Electronic Publication: 2019 Mar 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Disease Models, Animal*
Precision Medicine*
Immune System Diseases/*immunology
Animals ; Cell Transplantation ; Humans ; Immune System/cytology ; Immune System/physiology ; Immune System Diseases/genetics ; Immune System Diseases/pathology ; Mice ; Transplantation, Heterologous
Czasopismo naukowe

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