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Title:

Genetic risk converges on regulatory networks mediating early type 2 diabetes

Authors:

Walker, John T.
Saunders, Diane C.
Rai, Vivek
Chen, Hung-Hsin
Orchard, Peter
Dai, Chunhua
Pettway, Yasminye D.
Hopkirk, Alexander L.
Reihsmann, Conrad V.
Tao, Yicheng
Fan, Simin
Shrestha, Shristi
Varshney, Arushi
Petty, Lauren E.
Wright, Jordan J.
Ventresca, Christa
Agarwala, Samir
Aramandla, Radhika
Poffenberger, Greg
Jenkins, Regina
Mei, Shaojun
Hart, Nathaniel J.
Phillips, Sharon
Kang, Hakmook
Greiner, Dale L.
Shultz, Leonard D.
Bottino, RitaAff9, Aff10
Liu, Jie
Below, Jennifer E.
Parker, Stephen C. J.Aff3, Aff5, Aff11, IDs41586023066932_cor31
Powers, Alvin C.Aff1, Aff2, Aff12, IDs41586023066932_cor32
Brissova, MarcelaAff2, IDs41586023066932_cor33

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Nature: International weekly journal of science. 624(7992):621-629

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Title:

Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells

Authors:

Gong, Zheng
Li, Qing
Shi, Jiayuan
Liu, Edison T.
Shultz, Leonard D.
Ren, Guangwen

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In Cell Metabolism 6 December 2022 34(12):1960-1976

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Title:

Circulating CD34+ cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice

Authors:

Saito, NoriyukiAff1, Aff2
Yamauchi, Takuji
Kawano, Noriaki
Ono, Rintaro
Yoshida, Shuro
Miyamoto, Toshihiro
Kamimura, Tomohiko
Shultz, Leonard D.
Saito, Yoriko
Takenaka, Katsuto
Shimoda, Kazuya
Harada, Mine
Akashi, KoichiAff1, IDs1218502103239y_cor13
Ishikawa, FumihikoAff3, IDs1218502103239y_cor14

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International Journal of Hematology. 115(2):198-207

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Title:

Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice

Authors:

Saito, Yoriko
Shultz, Leonard D.
Ishikawa, Fumihiko

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In Trends in Immunology August 2020 41(8):706-720

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Title:

Improved mouse models and advanced genetic and genomic technologies for the study of neutrophils

Authors:

Hosur, Vishnu
Skelly, Daniel A.
Francis, Christopher
Low, Benjamin E.
Kohar, Vivek
Burzenski, Lisa M.
Amiji, Mansoor M.
Shultz, Leonard D.
Wiles, Michael V.

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In Drug Discovery Today June 2020 25(6):1013-1025

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Inactive rhomboid proteins RHBDF1 and RHBDF2 (iRhoms): a decade of research in murine models

Authors:

Burzenski, Lisa M.
Low, Benjamin E.
Kohar, Vivek
Shultz, Leonard D.
Wiles, Michael V.
Hosur, VishnuAff1, IDs00335021099103_cor6

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Mammalian Genome: Precision and Functional Genomics. 32(6):415-426

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Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis

Authors:

Saunders, Diane C.
Brissova, Marcela
Phillips, Neil
Shrestha, Shristi
Walker, John T.
Aramandla, Radhika
Poffenberger, Greg
Flaherty, David K.
Weller, Kevin P.
Pelletier, Julie
Cooper, Tracy
Goff, Matt T.
Virostko, John
Shostak, Alena
Dean, E. Danielle
Greiner, Dale L.
Shultz, Leonard D.
Prasad, Nripesh
Levy, Shawn E.
Carnahan, Robert H.
Dai, Chunhua
Sévigny, Jean
Powers, Alvin C.

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In Cell Metabolism 5 March 2019 29(3):745-754

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Title:

Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing

Authors:

Hosur, Vishnu
Burzenski, Lisa M.
Stearns, Timothy M.
Farley, Michelle L.
Sundberg, John P.
Wiles, Michael V.
Shultz, Leonard D.

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In Experimental and Molecular Pathology April 2017 102(2):337-346

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Title:

Humanized mouse models of immunological diseases and precision medicine

Authors:

Shultz, Leonard D.
Keck, James
Burzenski, Lisa
Jangalwe, Sonal
Vaidya, Shantashri
Greiner, Dale L.
Brehm, Michael A.

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Mammalian Genome. 30(5-6):123-142

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Title:

Humanized mouse model of mast cell–mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis

Authors:

Bryce, Paul J.
Falahati, Rustom
Kenney, Laurie L.
Leung, John
Bebbington, Christopher
Tomasevic, Nenad
Krier, Rebecca A.
Hsu, Chia-Lin
Shultz, Leonard D.
Greiner, Dale L.
Brehm, Michael A.

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In The Journal of Allergy and Clinical Immunology September 2016 138(3):769-779

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Title:

Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status

Authors:

Li, PeishanAff1, Aff2
Lu, MingAff2, Aff3
Shi, Jiayuan
Hua, Li
Gong, Zheng
Li, Qing
Shultz, Leonard D.
Ren, Guangwen

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Nature Communications. 11(1)

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Title:

NOD-scid IL2rγ mice lacking TLR4 support human immune system development and the study of human-specific innate immunity.

Authors:

Aryee, Ken-Edwin
Shultz, Leonard D
Burzenski, Lisa M
Greiner, Dale L
Brehm, Michael A

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Subject Terms:

NATURAL immunity
IMMUNE system
TOLL-like receptors
SYSTEMS development
B cells

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Journal of Leukocyte Biology; May2023, Vol. 113 Issue 5, p418-433, 16p

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NUCLEAR Suppliers Group (Company)

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Title:

Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells

Authors:

Wagenblast, Elvin
Azkanaz, Maria
Smith, Sabrina A.
Shakib, Lorien
McLeod, Jessica L.
Krivdova, Gabriela
Araújo, Joana
Shultz, Leonard D.
Gan, Olga I.
Dick, John E.Aff1, Aff3
Lechman, Eric R.

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Nature Communications. 10(1)

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Title:

Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop

Authors:

Bedognetti, Davide
Ceccarelli, Michele
Galluzzi, LorenzoAff3, Aff4, Aff5
Lu, Rongze
Palucka, Karolina
Samayoa, Josue
Spranger, Stefani
Warren, Sarah
Wong, Kwok-Kin
Ziv, Elad
Chowell, Diego
Coussens, Lisa M.
De Carvalho, Daniel D.
DeNardo, David G.
Galon, Jérôme
Kaufman, Howard L.
Kirchhoff, Tomas
Lotze, Michael T.
Luke, Jason J.
Minn, Andy J.
Politi, Katerina
Shultz, Leonard D.
Simon, Richard
Thórsson, Vésteinn
Weidhaas, Joanne B.
Ascierto, Maria Libera
Ascierto, Paolo Antonio
Barnes, James M.
Barsan, Valentin
Bommareddy, Praveen K.
Bot, Adrian
Church, Sarah E.
Ciliberto, Gennaro
De Maria, Andrea
Draganov, Dobrin
Ho, Winson S.
McGee, Heather M.
Monette, Anne
Murphy, Joseph F.
Nisticò, Paola
Park, Wungki
Patel, Maulik
Quigley, Michael
Radvanyi, Laszlo
Raftopoulos, Harry
Rudqvist, Nils-Petter
Snyder, Alexandra
Sweis, Randy F.
Valpione, Sara
Zappasodi, RobertaAff47, Aff48
Butterfield, Lisa H.
Disis, Mary L.
Fox, Bernard A.
Cesano, Alessandra
Marincola, Francesco M.
Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups

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Journal for ImmunoTherapy of Cancer. 7(1)

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Title:

Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop

Authors:

Bedognetti, Davide
Ceccarelli, Michele
Galluzzi, LorenzoAff3, Aff4, Aff5
Lu, Rongze
Palucka, Karolina
Samayoa, Josue
Spranger, Stefani
Warren, Sarah
Wong, Kwok-Kin
Ziv, Elad
Chowell, Diego
Coussens, Lisa M.
De Carvalho, Daniel D.
DeNardo, David G.
Galon, Jérôme
Kaufman, Howard L.
Kirchhoff, Tomas
Lotze, Michael T.
Luke, Jason J.
Minn, Andy J.
Politi, Katerina
Shultz, Leonard D.
Simon, Richard
Thórsson, Vésteinn
Weidhaas, Joanne B.
Ascierto, Maria Libera
Ascierto, Paolo Antonio
Barnes, James M.
Barsan, Valentin
Bommareddy, Praveen K.
Bot, Adrian
Church, Sarah E.
Ciliberto, Gennaro
De Maria, Andrea
Draganov, Dobrin
Ho, Winson S.
McGee, Heather M.
Monette, Anne
Murphy, Joseph F.
Nisticò, Paola
Park, Wungki
Patel, Maulik
Quigley, Michael
Radvanyi, Laszlo
Raftopoulos, Harry
Rudqvist, Nils-Petter
Snyder, Alexandra
Sweis, Randy F.
Valpione, Sara
Zappasodi, RobertaAff47, Aff48
Butterfield, Lisa H.
Disis, Mary L.
Fox, Bernard A.
Cesano, Alessandra
Marincola, Francesco M.
Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups

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Journal for ImmunoTherapy of Cancer. 7(1)

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Title:

Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection

Authors:

Sewald, Xaver
Ladinsky, Mark S.
Uchil, Pradeep D.
Beloor, Jagadish
Pi, Ruoxi
Herrmann, Christin
Motamedi, Nasim
Murrooka, Thomas T.
Brehm, Michael A.
Greiner, Dale L.
Shultz, Leonard D.
Mempel, Thorsten R.
Bjorkman, Pamela J.
Kumar, Priti
Mothes, Walther

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Science, 2015 Oct . 350(6260), 563-567.

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Title:

Humanized Mice as Models for Human Disease

Authors:

McCune, Joseph M.Aff6, Aff7
Shultz, Leonard D.

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Humanized Mice for HIV Research. :15-24

Degree:

MD, PhD

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Title:

Dystrophin and dysferlin double mutant mice: a novel model for rhabdomyosarcoma

Authors:

Hosur, Vishnu
Kavirayani, Anoop
Riefler, Jennifer
Carney, Lisa M.B.
Lyons, Bonnie
Gott, Bruce
Cox, Gregory A.
Shultz, Leonard D.

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In Cancer Genetics May 2012 205(5):232-241

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Title:

Clathrin light chain-conjugated drug delivery for cancer.

Authors:

Sungwook Jung
Liwei Jiang
Jing Zhao
Shultz, Leonard D.
Greiner, Dale L.
Munhyung Bae
Xiaofei Li
Ordikhani, Farideh
Rui Kuai
Joseph, John
Kasinath, Vivek
Elmaleh, David R.
Abdi, Reza

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Subject Terms:

PACLITAXEL
TARGETED drug delivery
DRUG delivery systems
CLATHRIN
ANTINEOPLASTIC agents

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Bioengineering & Translational Medicine; Jan2023, Vol. 8 Issue 1, p1-14, 14p

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Modeling Human Leukemia Using Immune-Compromised Mice

Authors:

Ishikawa, Fumihiko
Saito, Yariko
Shultz, Leonard D.

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Mouse Models of Human Blood Cancers : Basic Research and Pre-clinical Applications. :121-132

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NOD-scidIl2rg : A Model for Stromal Cell–Tumor Cell Interaction for Human Colon Cancer

Authors:

Maykel, Justin
Liu, Jian Hua
Li, Hanchen
Shultz, Leonard D.
Greiner, Dale L.
Houghton, JeanMarie

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Digestive Diseases and Sciences. June 2014 59(6):1169-1179

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Title:

Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury

Authors:

Moser, Jill
van Ark, Joris
van Dijk, Marcory C.
Greiner, Dale L.
Shultz, Leonard D.
van Goor, Harry
Hillebrands, Jan-Luuk

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Scientific Reports. 6(1)

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Title:

In Childhood Acute Lymphoblastic Leukemia, Blasts at Different Stages of Immunophenotypic Maturation Have Stem Cell Properties

Authors:

le Viseur, Christoph
Hotfilder, Marc
Bomken, Simon
Wilson, Kerrie
Röttgers, Silja
Schrauder, André
Rosemann, Annegret
Irving, Julie
Stam, Ronald W.
Shultz, Leonard D.
Harbott, Jochen
Jürgens, Heribert
Schrappe, Martin
Pieters, Rob
Vormoor, Josef

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In Cancer Cell 8 July 2008 14(1):47-58

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Title:

A novel clinically relevant graft‐versus‐leukemia model in humanized mice.

Authors:

Jia, Bei
Zhao, Chenchen
Bayerl, Michael
Shike, Hiroko
Claxton, David F.
Ehmann, W Christopher
Mineishi, Shin
Schell, Todd D.
Zheng, Pan
Zhang, Yi
Shultz, Leonard D.
Prabhu, K. Sandeep
Paulson, Robert F.
Zheng, Hong

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Subject Terms:

HEMATOPOIETIC stem cell transplantation
HEMATOPOIETIC stem cells
ANIMAL disease models
ACUTE myeloid leukemia

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Journal of Leukocyte Biology; Feb2022, Vol. 111 Issue 2, p427-437, 11p

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NUCLEAR Suppliers Group (Company)

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Title:

Cellular Origin of Follicular Dendritic Cells

Authors:

Kapasi, Zoher F.Aff2, Aff3
Kosco-Vilbois, Marie H.
Shultz, Leonard D.
Tew, John G.
Szakal, Andras K.

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In Vivo Immunology : Regulatory Processes during Lymphopoiesis and Immunopoiesis. 355:231-235

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Cellular Requirements for Functional Reconstitution of Follicular Dendritic Cells in Scid Mice

Authors:

Kapasi, Zoher F.
Szakal, Andras K.
Burton, Gregory F.
Tew, John G.
Shultz, Leonard D.

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Dendritic Cells in Fundamental and Clinical Immunology. 329:383-386

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Immunophenotypic and Ultrastructural Differentiation and Maturation of Nonlymphoid Dendritic Cells in Osteopetrotic (op) Mice with the Total Absence of Macrophage Colony Stimulating Factor Activity

Authors:

Takahashi, Kiyoshi
Naito, Makoto
Morioka, Yuki
Shultz, Leonard D.

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Dendritic Cells in Fundamental and Clinical Immunology. 329:293-297

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Epidermal Dendritic Cells in Immunodeficient Mice

Authors:

Sprecher, Eli
Shultz, Leonard D.
Becker, Yechiel

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Skin Langerhans (Dendritic) Cells in Virus Infections and AIDS. 7:59-76

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Epidermal Dendritic Cells in Aged C57BL/6 J MICE

Authors:

Sprecher, Eli
Shultz, Leonard D.Aff2, Aff3
Becker, Yechiel

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Skin Langerhans (Dendritic) Cells in Virus Infections and AIDS. 7:99-118

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An Assay for Human Hematopoietic Stem Cells Based on Transplantation into Nonobese Diabetic Recombination Activating Gene-Null Perforin-Null Mice

Authors:

Minamiguchi, Hitoshi
Wingard, John R.
Laver, Joseph H.
Mainali, Elsie S.
Shultz, Leonard D.
Ogawa, Makio

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In Biology of Blood and Marrow Transplantation 2005 11(7):487-494

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Title:

SHP-1 regulates STAT6 phosphorylation and IL-4-mediated function in a cell type-specific manner

Authors:

Huang, Zan
Coleman, John M.
Su, Yan
Mann, Meredith
Ryan, John
Shultz, Leonard D.
Huang, Hua

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In Cytokine 2005 29(3):118-124

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Title:

Genetic Separation of the Transplantation Tolerance and Autoimmune Phenotypes in NOD Mice

Authors:

Pearson, Todd
Markees, Thomas G.
Serreze, David V.
Pierce, Melissa A.
Wicker, Linda S.
Peterson, Laurence B.
Shultz, Leonard D.
Mordes, John P.
Rossini, Aldo A.
Greiner, Dale L.

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Reviews in Endocrine and Metabolic Disorders. September 2003 4(3):255-261

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Title:

Improved B cell development in humanized NOD -scid IL2Rγ mice transgenically expressing human stem cell factor, granulocyte-macrophage colony-stimulating factor and interleukin-3.

Authors:

Jangalwe, Sonal
Shultz, Leonard D.
Mathew, Anuja
Brehm, Michael A.

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Immunity, Inflammation & Disease. Dec2016, Vol. 4 Issue 4, p427-440. 14p.

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Title:

Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD- scid and NOD- Rag1nullPrf1null mice

Authors:

Banuelos, Scott J
Shultz, Leonard D
Greiner, Dale L
Burzenski, Lisa M
Gott, Bruce
Lyons, Bonnie L
Rossini, Aldo A
Appel, Michael C

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In Clinical Immunology 2004 112(3):273-283

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Title:

Production of Immunoglobulin Isotypes by Ly-$^{1}$ B cells in Viable Motheaten and Normal mice

Authors:

Sidman, Charles L.
Shultz, Leonard D.
Hardy, Richard R.
Hayakawa, Kyoko
Herzenberg, Lee A.

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Science, 1986 Jun . 232(4756), 1423-1425.

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Title:

The Molecular Bases of Spontaneous Immunological Mutations in the Mouse and Their Homologous Human Diseases

Authors:

Joliat, Melissa J.
Shultz, Leonard D.

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In Clinical Immunology November 2001 101(2):113-129

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Title:

T cell receptor expression is not required for the localization and differentiation of intraepithelial lymphocytes

Authors:

Croitoru, Kenneth
Stead, Ron H.
Bienenstock, John
Shultz, Leonard D.
Ernst, Peter B.

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Immunologic Research. December 1991 10(3-4):293-295

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Title:

Humanized mice for immune system investigation: progress, promise and challenges.

Authors:

Shultz, Leonard D.
Brehm, Michael A.
Garcia-Martinez, J. Victor
Greiner, Dale L.

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Nature Reviews Immunology. Nov2012, Vol. 12 Issue 11, p786-798. 13p. 2 Diagrams, 5 Charts.

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Title:

Humanized mice as a preclinical tool for infectious disease and biomedical research.

Authors:

Shultz, Leonard D. (AUTHOR)
Brehm, Michael A. (AUTHOR)
Bavari, Sina (AUTHOR)
Greiner, Dale L. (AUTHOR)

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Annals of the New York Academy of Sciences. Dec2011, Vol. 1245 Issue 1, p50-54. 5p.

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Title:

Humanized NOD/LtSz- scid IL2 Receptor Common Gamma Chain Knockout Mice in Diabetes Research.

Authors:

SHULTZ, LEONARD D. (AUTHOR)
PEARSON, TODD (AUTHOR)
KING, MARIE (AUTHOR)
GIASSI, LISA (AUTHOR)
CARNEY, LISA (AUTHOR)
GOTT, BRUCE (AUTHOR)
LYONS, BONNIE (AUTHOR)
ROSSINI, ALDO A. (AUTHOR)
GREINER, DALE L. (AUTHOR)

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Annals of the New York Academy of Sciences. 2007, Vol. 1103, p77-89. 13p. 1 Color Photograph, 1 Diagram.

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Title:

Humanized mice in translational biomedical research.

Authors:

Shultz, Leonard D.
Ishikawa, Fumihiko
Greiner, Dale L.

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Nature Reviews Immunology. Feb2007, Vol. 7 Issue 2, p118-130. 13p. 2 Diagrams, 2 Charts.

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Title:

Thymic Microenvironment and NZB Mice: The Abnormal Thymic Microenvironment of New Zealand Mice Correlates with Immunopathology

Authors:

Takeoka, Yuichi
Taguchi, Nobuhisa
Kotzin, Brian L.
Bennett, Sean
Vyse, Timothy J.
Boyd, Richard L.
Naiki, Mitsuru
Konishi, Jin-emon
Ansari, Aftab A.
Shultz, Leonard D.
Gershwin, M.Eric

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Source:

In Clinical Immunology March 1999 90(3):388-398

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Title:

The Mouse Mutant 'Wasted': An Animal Model for Ataxia-Telangiectasia

Authors:

Inoue, Tadashi
Tezuka, Hideo
Kada, Tsuneo
Aikawa, Katsuhiro
Shultz, Leonard D.

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Source:

Antimutagenesis and Anticarcinogenesis Mechanisms. 39:323-335

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Title:

Pneumocystis carinii Pneumonia in scid/scid Mice

Authors:

Shultz, Leonard D.
Schweitzer, Peter A.
Hall, Elaine J.
Sundberg, John P.
Taylor, Suzanne
Walzer, Peter D.

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The Scid Mouse : Characterization and Potential Uses. 152:243-249

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Title:

Tissue‑specific role of RHBDF2 in cutaneous wound healing and hyperproliferative skin disease.

Authors:

Hosur, Vishnu
Lyons, Bonnie L.
Burzenski, Lisa M.
Shultz, Leonard D.

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BMC Research Notes; 11/7/2017, Vol. 10, p1-7, 7p, 2 Color Photographs, 1 Graph

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Title:

Genetically modified human CD4 T cells can be evaluated in vivo without lethal graft-versus-host disease.

Authors:

Ali, Riyasat
Babad, Jeffrey
Follenzi, Antonia
Gebe, John A.
Brehm, Michael A.
Nepom, Gerald T.
Shultz, Leonard D.
Greiner, Dale L.
DiLorenzo, Teresa P.

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Subject Terms:

GRAFT versus host disease
CD4 antigen
CELLULAR therapy
IMMUNOTHERAPY
T cell receptors
ANTINEOPLASTIC agents

Source:

Immunology; Aug2016, Vol. 148 Issue 4, p339-351, 13p

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Title:

The immunological mouse mutants nude (nu) and rhino (hr ) generate cytotoxic effector cells following adoptive immunotherapy but fail to reject a transplanted tumor

Authors:

Evans, Robert
Duffy, Theodore M.
Shultz, Leonard D.

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Cancer Immunology, Immunotherapy. February 1988 26(1):35-42

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Title:

Mutations in mice that influence natural killer (NK) cell activity

Authors:

Clark, Edward A.
Shultz, Leonard D.
Pollack, Sylvia B.

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Immunogenetics. December 1981 12(1):601-613

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Title:

Genetic control of contact sensitivity in mice: Effect ofH-2 and nonH-2 loci

Authors:

Shultz, Leonard D.
Bailey, Donald W.

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Source:

Immunogenetics. December 1974 1(1):570-583

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Title:

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes

Authors:

Brissova, Marcela
Haliyur, Rachana
Saunders, Diane
Shrestha, Shristi
Dai, Chunhua
Blodgett, David M.
Bottino, Rita
Campbell-Thompson, Martha
Aramandla, Radhika
Poffenberger, Gregory
Lindner, Jill
Pan, Fong Cheng
von Herrath, Matthias G.
Greiner, Dale L.
Shultz, Leonard D.
Sanyoura, May
Philipson, Louis H.
Atkinson, Mark
Harlan, David M.
Levy, Shawn E.
Prasad, Nripesh
Stein, Roland
Powers, Alvin C.

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Cell Reports; March 2018, Vol. 22 Issue: 10 p2667-2676, 10p

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Title:

Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of α-1 Antitrypsin Deficiency

Authors:

Borel, Florie
Tang, Qiushi
Gernoux, Gwladys
Greer, Cynthia
Wang, Ziqiong
Barzel, Adi
Kay, Mark A.
Shultz, Leonard D.
Greiner, Dale L.
Flotte, Terence R.
Brehm, Michael A.
Mueller, Christian

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Molecular Therapy; November 2017, Vol. 25 Issue: 11 p2477-2489, 13p

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Title:

Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD--scid IL-2rg RIP-DTR mice engrafted with human islets.

Authors:

Chaoxing Yang
Loehn, Matthias
Jurczyk, Agata
Przewozniak, Natalia
Leehy, Linda
Herrera3, Pedro L.
Shultz, Leonard D.
Greiner, Dale L.
Harlan, David M.
Bortell, Rita

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Subject Terms:

GLUCAGON-like peptides
PANCREATIC beta cells
PHYSIOLOGICAL effects of insulin
GLUCOSE tolerance tests
DIAGNOSIS of diabetes

Source:

Diabetes, Metabolic Syndrome & Obesity: Targets & Therapy; Aug2015, Vol. 8, p387-398, 12p

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