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Wyszukujesz frazę ""Signal transducer and activator of transcription 3"" wg kryterium: Temat


Wyświetlanie 1-9 z 9
Tytuł :
Targeting the PI3K/STAT3 axis modulates age-related differences in macrophage phenotype in rats with myocardial infarction.
Autorzy :
Lin CC; Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan.
Chen SY; Cardiovascular Institute, An Nan Hospital, China Medical University, Tainan, Taiwan.
Lien HY; Department of pharmacy, Kaohsiung Veterans general hospital Tainan branch, Tainan, Taiwan.
Lin SZ; Bioinnovation Center, Tzu Chi foundation, Department of Neurosurgery, Buddhist Tzu Chi General Hospital, Tzu Chi University, Yunlin, Taiwan.
Lee TM; Cardiovascular Institute, An Nan Hospital, Tainan, Taiwan.; Department of Medicine, China Medical University, Taichung, Taiwan.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2019 Sep; Vol. 23 (9), pp. 6378-6392. Date of Electronic Publication: 2019 Jul 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Macrophages/*metabolism
Myocardial Infarction/*metabolism
Myocardium/*metabolism
Phosphatidylinositol 3-Kinase/*metabolism
STAT3 Transcription Factor/*metabolism
Animals ; Fibrosis/drug therapy ; Fibrosis/metabolism ; Interleukin-10/metabolism ; Macrophages/drug effects ; Male ; Myocardial Infarction/drug therapy ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Myofibroblasts/drug effects ; Myofibroblasts/metabolism ; Phenotype ; Phosphorylation/drug effects ; Phosphorylation/physiology ; Phthalic Anhydrides/pharmacology ; Rats ; Rats, Wistar ; Signal Transduction/drug effects ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Low-dose curcumin stimulates proliferation of rat embryonic neural stem cells through glucocorticoid receptor and STAT3.
Autorzy :
Ma XX; Department of Anesthesiology, Critical Care and Pain Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Zhejiang Province Key Lab of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Department of Anesthesiology, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Liu J; Department of Anesthesiology, Critical Care and Pain Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Zhejiang Province Key Lab of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Wang CM; Department of Anesthesiology, Critical Care and Pain Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Zhejiang Province Key Lab of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Zhou JP; Department of Anesthesiology, Critical Care and Pain Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Zhejiang Province Key Lab of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
He ZZ; Department of Anesthesiology, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Lin H; Department of Anesthesiology, Critical Care and Pain Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Zhejiang Province Key Lab of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
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Źródło :
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2018 Oct; Vol. 24 (10), pp. 940-946. Date of Electronic Publication: 2018 Mar 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Cell Proliferation/*drug effects
Curcumin/*pharmacology
Neural Stem Cells/*drug effects
Receptors, Glucocorticoid/*metabolism
STAT3 Transcription Factor/*metabolism
Animals ; Bromodeoxyuridine/metabolism ; Cells, Cultured ; Dose-Response Relationship, Drug ; Embryo, Mammalian ; L-Lactate Dehydrogenase/metabolism ; RNA, Messenger ; Rats ; Rats, Sprague-Dawley ; Receptors, Glucocorticoid/genetics ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
Heat-shock transcription factor 1 is critically involved in the ischaemia-induced cardiac hypertrophy via JAK2/STAT3 pathway.
Autorzy :
Yuan L; Department of kinesiology, Institute of physical education, Shanghai Normal University, Shanghai, China.
Qiu L; Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ye Y; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biological Science, Fudan University, Shanghai, China.
Wu J; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biological Science, Fudan University, Shanghai, China.
Wang S; Department of Computer Tomography and Magnetic Imaging, Yidu Central Hospital, Weifang Medical College, Weifang, China.
Wang X; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biological Science, Fudan University, Shanghai, China.
Zhou N; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zou Y; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biological Science, Fudan University, Shanghai, China.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2018 Sep; Vol. 22 (9), pp. 4292-4303. Date of Electronic Publication: 2018 Jul 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cardiomegaly/*genetics
Heat Shock Transcription Factors/*genetics
Janus Kinase 2/*genetics
Myocardial Infarction/*genetics
Myocardial Ischemia/*genetics
STAT3 Transcription Factor/*genetics
Animals ; Animals, Newborn ; Cardiomegaly/diagnostic imaging ; Cardiomegaly/metabolism ; Cardiomegaly/pathology ; Cell Hypoxia ; Disease Models, Animal ; Echocardiography ; Gene Expression Regulation ; Heat Shock Transcription Factors/antagonists & inhibitors ; Heat Shock Transcription Factors/metabolism ; Janus Kinase 2/metabolism ; Mice ; Mice, Knockout ; Myocardial Infarction/diagnostic imaging ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardial Ischemia/diagnostic imaging ; Myocardial Ischemia/metabolism ; Myocardial Ischemia/pathology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Primary Cell Culture ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Rats ; Rats, Sprague-Dawley ; STAT3 Transcription Factor/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Phosphorylated signal transducer and activator of transcription 3 in the epidermis in adult-onset Still's disease.
Autorzy :
Takeichi T; Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Watanabe N; Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Muro Y; Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Teshigawara S; Department of General Medicine/Family and Community Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Sato M; Department of General Medicine/Family and Community Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Ban N; Department of General Medicine/Family and Community Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Akiyama M; Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
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Źródło :
The Journal of dermatology [J Dermatol] 2017 Oct; Vol. 44 (10), pp. 1172-1175. Date of Electronic Publication: 2017 May 04.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Epidermis/*pathology
Exanthema/*pathology
STAT3 Transcription Factor/*metabolism
Still's Disease, Adult-Onset/*pathology
Adult ; Aged ; Aged, 80 and over ; Cell Nucleus/pathology ; Epidermal Cells ; Female ; Healthy Volunteers ; Humans ; Immunohistochemistry ; Keratinocytes/pathology ; Male ; Middle Aged ; Phosphorylation
Czasopismo naukowe
Tytuł :
Hypoxia-inhibited DUSP2 expression promotes IL-6/STAT3 signaling in endometriosis.
Autorzy :
Hsiao KY; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chang N; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Department of Obstetrics and Gynecology, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan.
Tsai JL; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Lin SC; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Tsai SJ; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wu MH; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Department of Obstetrics and Gynecology, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan.
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Źródło :
American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2017 Oct; Vol. 78 (4). Date of Electronic Publication: 2017 Apr 25.
Typ publikacji :
Journal Article
MeSH Terms :
Dual Specificity Phosphatase 2/*genetics
Endometriosis/*immunology
Endometrium/*pathology
Hypoxia/*immunology
Interleukin-6/*metabolism
STAT3 Transcription Factor/*metabolism
Stromal Cells/*physiology
Adolescent ; Adult ; Apoptosis ; Caspase 3/metabolism ; Cells, Cultured ; Child ; Choristoma ; Dual Specificity Phosphatase 2/metabolism ; Endometriosis/genetics ; Female ; Gene Expression Regulation ; Humans ; Hypoxia/genetics ; Middle Aged ; Signal Transduction ; Young Adult
Czasopismo naukowe
Tytuł :
Critical contribution of the interleukin-6/signal transducer and activator of transcription 3 axis to vasculopathy associated with systemic sclerosis.
Autorzy :
Taniguchi T; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Asano Y; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Fukasawa T; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Yoshizaki A; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Sato S; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
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Źródło :
The Journal of dermatology [J Dermatol] 2017 Aug; Vol. 44 (8), pp. 967-971. Date of Electronic Publication: 2017 Mar 24.
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
Antibodies, Monoclonal, Humanized/*pharmacology
Interleukin-6/*metabolism
STAT3 Transcription Factor/*metabolism
Scleroderma, Systemic/*pathology
Signal Transduction/*drug effects
Vascular Diseases/*pathology
Adult ; Aged ; Antibodies, Monoclonal, Humanized/therapeutic use ; Capillaries/diagnostic imaging ; Capillaries/drug effects ; Dermoscopy ; Endothelial Cells/drug effects ; Endothelial Cells/pathology ; Female ; Humans ; Male ; Middle Aged ; Nails/blood supply ; Nails/diagnostic imaging ; Pilot Projects ; Proto-Oncogene Protein c-fli-1 ; Receptors, Interleukin-6/antagonists & inhibitors ; Scleroderma, Systemic/drug therapy ; Skin/drug effects ; Skin/pathology ; Vascular Diseases/drug therapy ; Vascular Diseases/etiology
Czasopismo naukowe
Tytuł :
Helicobacter pylori Activates IL-6-STAT3 Signaling in Human Gastric Cancer Cells: Potential Roles for Reactive Oxygen Species.
Autorzy :
Piao JY; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.
Lee HG; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.
Kim SJ; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.
Kim DH; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.
Han HJ; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.
Ngo HK; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.
Park SA; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.
Woo JH; Department of Food and Nutrition, Sungshin Women's University, Seoul, South Korea.
Lee JS; Department of Health and Functional Food, College of Medicine and Science, Jeonju University, Jeonju, South Korea.
Na HK; Department of Food and Nutrition, Sungshin Women's University, Seoul, South Korea.
Cha YN; College of Medicine, Inha University, Incheon, South Korea.
Surh YJ; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea. .; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea. .; Cancer Research Institute, Seoul National University, Seoul, South Korea. .
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Źródło :
Helicobacter [Helicobacter] 2016 Oct; Vol. 21 (5), pp. 405-16. Date of Electronic Publication: 2016 Feb 23.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Helicobacter pylori/*immunology
Interleukin-6/*metabolism
Reactive Oxygen Species/*metabolism
STAT3 Transcription Factor/*metabolism
Blotting, Western ; Cell Line, Tumor ; Coculture Techniques ; Electrophoretic Mobility Shift Assay ; Humans ; Immunohistochemistry ; Immunoprecipitation ; Reverse Transcriptase Polymerase Chain Reaction ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
Persistent cytotoxic T lymphocyte expansions after allogeneic haematopoietic stem cell transplantation: kinetics, clinical impact and absence of STAT3 mutations.
Autorzy :
Muñoz-Ballester J; Haematology and Medical Oncology Department, University Hospital Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, Murcia, Spain.
Chen-Liang TH; Haematology and Medical Oncology Department, University Hospital Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, Murcia, Spain.
Hurtado AM; Haematology and Medical Oncology Department, University Hospital Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, Murcia, Spain.
Heras I; Haematology and Medical Oncology Department, University Hospital Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, Murcia, Spain.
de Arriba F; Haematology and Medical Oncology Department, University Hospital Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, Murcia, Spain.
García-Malo MD; Haematology and Medical Oncology Department, University Hospital Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, Murcia, Spain.
Iniesta P; Haematology and Medical Oncology Department, University Hospital Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, Murcia, Spain.
Lozano ML; Haematology and Medical Oncology Department, University Hospital Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, Murcia, Spain.
Nieto JB; Haematology and Medical Oncology Department, University Hospital Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, Murcia, Spain.
Ortuño FJ; Haematology and Medical Oncology Department, University Hospital Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, Murcia, Spain.
Osma Mdel M; Haematology and Medical Oncology Department, University Hospital Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, Murcia, Spain.
Padilla J; Haematology and Medical Oncology Department, University Hospital Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, Murcia, Spain.
Teruel-Montoya R; Haematology and Medical Oncology Department, University Hospital Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, Murcia, Spain.
Vicente V; Haematology and Medical Oncology Department, University Hospital Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, Murcia, Spain.
Castilla-Llorente C; Haematology and Medical Oncology Department, University Hospital Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, Murcia, Spain.
Jerez A; Haematology and Medical Oncology Department, University Hospital Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, Murcia, Spain.
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Źródło :
British journal of haematology [Br J Haematol] 2016 Mar; Vol. 172 (6), pp. 937-46. Date of Electronic Publication: 2016 Jan 05.
Typ publikacji :
Journal Article
MeSH Terms :
Hematopoietic Stem Cell Transplantation*
Mutation*
Leukemia, Large Granular Lymphocytic/*therapy
STAT3 Transcription Factor/*genetics
T-Lymphocytes, Cytotoxic/*immunology
Adult ; Female ; Gene Rearrangement, T-Lymphocyte/genetics ; Graft vs Host Disease/immunology ; Graft vs Host Disease/prevention & control ; Humans ; Immunophenotyping ; Leukemia, Large Granular Lymphocytic/genetics ; Leukemia, Large Granular Lymphocytic/immunology ; Longitudinal Studies ; Male ; Middle Aged ; Neoplasm Proteins/genetics ; Survival Analysis ; Young Adult
Czasopismo naukowe
Tytuł :
Young investigator challenge: Application of cytologic techniques to circulating tumor cell specimens: Detecting activation of the oncogenic transcription factor STAT3.
Autorzy :
Lowe AC; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.
Pignon JC; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
Carvo I; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
Drage MG; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.
Constantine NM; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
Jones N; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Kroll Y; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Frank DA; Harvard Medical School, Boston, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Signoretti S; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.
Cibas ES; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.
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Źródło :
Cancer cytopathology [Cancer Cytopathol] 2015 Dec; Vol. 123 (12), pp. 696-706.
Typ publikacji :
Journal Article
MeSH Terms :
Neoplastic Cells, Circulating*
Biomarkers, Tumor/*analysis
Cytodiagnosis/*methods
Cytological Techniques/*methods
STAT3 Transcription Factor/*analysis
Humans ; Immunohistochemistry
Czasopismo naukowe
    Wyświetlanie 1-9 z 9

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