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Wyszukujesz frazę ""Simian Acquired Immunodeficiency Syndrome"" wg kryterium: Temat


Tytuł :
Characterization of Nef expression in different brain regions of SIV-infected macaques.
Autorzy :
Yarandi SS; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States of America.
Robinson JA; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States of America.
Vakili S; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States of America.
Donadoni M; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States of America.
Burdo TH; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States of America.
Sariyer IK; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Nov 02; Vol. 15 (11), pp. e0241667. Date of Electronic Publication: 2020 Nov 02 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cerebellum/*metabolism
Gene Products, nef/*genetics
Hippocampus/*metabolism
Simian Acquired Immunodeficiency Syndrome/*metabolism
Animals ; Cerebellum/virology ; Gene Products, nef/metabolism ; Hippocampus/virology ; Macaca mulatta ; Male ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus/genetics ; Simian Immunodeficiency Virus/metabolism
Czasopismo naukowe
Tytuł :
Therapeutic vaccination of SIV-infected, ART-treated infant rhesus macaques using Ad48/MVA in combination with TLR-7 stimulation.
Autorzy :
Bricker KM; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States of America.
Obregon-Perko V; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States of America.
Uddin F; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States of America.
Williams B; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States of America.
Uffman EA; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America.
Garrido C; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America.
Fouda GG; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America.; Departments of Molecular Genetics and Microbiology and Pediatrics, Duke University School of Medicine, Durham, NC, United States of America.
Geleziunas R; Gilead Sciences, Inc., Foster City, CA, United States of America.
Robb M; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.
Michael N; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.
Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States of America.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, United States of America.
Chahroudi A; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States of America.; Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States of America.; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta and Emory University, Atlanta, GA, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Oct 26; Vol. 16 (10), pp. e1008954. Date of Electronic Publication: 2020 Oct 26 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
CD4-Positive T-Lymphocytes/*immunology
SAIDS Vaccines/*administration & dosage
Simian Acquired Immunodeficiency Syndrome/*drug therapy
Simian Immunodeficiency Virus/*immunology
Toll-Like Receptor 7/*agonists
Vaccination/*methods
Viremia/*drug therapy
Adenoviridae/genetics ; Animals ; Animals, Newborn ; CD4-Positive T-Lymphocytes/virology ; Female ; Genetic Vectors ; Macaca mulatta ; Male ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus/drug effects ; Viral Load ; Viremia/immunology ; Viremia/virology ; Virus Replication
Czasopismo naukowe
Tytuł :
SMAC Mimetic Plus Triple-Combination Bispecific HIVxCD3 Retargeting Molecules in SHIV.C.CH505-Infected, Antiretroviral Therapy-Suppressed Rhesus Macaques.
Autorzy :
Dashti A; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Waller C; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Mavigner M; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta and Emory University, Atlanta, Georgia, USA.
Schoof N; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Bar KJ; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Shaw GM; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Vanderford TH; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Liang S; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Lifson JD; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Dunham RM; HIV Drug Discovery, ViiV Healthcare, Research Triangle Park, North Carolina, USA.; UNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Ferrari G; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Tuyishime M; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Lam CK; MacroGenics, Inc., Rockville, Maryland, USA.
Nordstrom JL; MacroGenics, Inc., Rockville, Maryland, USA.
Margolis DM; UNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Silvestri G; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.; Emory Vaccine Center, Emory University, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Chahroudi A; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA .; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta and Emory University, Atlanta, Georgia, USA.
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Źródło :
Journal of virology [J Virol] 2020 Oct 14; Vol. 94 (21). Date of Electronic Publication: 2020 Oct 14 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alkynes/*pharmacology
Anti-Retroviral Agents/*pharmacology
Antibodies, Neutralizing/*pharmacology
Antibodies, Viral/*pharmacology
HIV Infections/*drug therapy
Oligopeptides/*pharmacology
Simian Acquired Immunodeficiency Syndrome/*drug therapy
Viremia/*drug therapy
Animals ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/virology ; Female ; Gene Expression Regulation ; HIV Infections/genetics ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/drug effects ; HIV-1/growth & development ; HIV-1/immunology ; Humans ; Inhibitor of Apoptosis Proteins/antagonists & inhibitors ; Inhibitor of Apoptosis Proteins/genetics ; Inhibitor of Apoptosis Proteins/immunology ; Macaca mulatta ; NF-kappa B/genetics ; NF-kappa B/immunology ; Reassortant Viruses/drug effects ; Reassortant Viruses/growth & development ; Reassortant Viruses/immunology ; Simian Acquired Immunodeficiency Syndrome/genetics ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus/drug effects ; Simian Immunodeficiency Virus/growth & development ; Simian Immunodeficiency Virus/immunology ; Viral Load/drug effects ; Viremia/genetics ; Viremia/immunology ; Viremia/virology ; Virus Latency/drug effects ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Regional Brain Recovery from Acute Synaptic Injury in Simian Immunodeficiency Virus-Infected Rhesus Macaques Associates with Heme Oxygenase Isoform Expression.
Autorzy :
Garcia-Mesa Y; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Garza R; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Diaz Ortiz ME; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Gruenewald AL; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Bastien BL; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Lobrovich R; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Irwin DJ; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Betts MR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Silvestri G; Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Druid Hills, Georgia, USA.
Kolson DL; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA .
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Źródło :
Journal of virology [J Virol] 2020 Sep 15; Vol. 94 (19). Date of Electronic Publication: 2020 Sep 15 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Brain/*metabolism
Brain Injuries/*metabolism
Heme Oxygenase (Decyclizing)/*metabolism
Simian Acquired Immunodeficiency Syndrome/*metabolism
Simian Immunodeficiency Virus/*immunology
Animals ; Anti-Inflammatory Agents ; Brain/pathology ; Brain/virology ; Brain Injuries/pathology ; Brain Injuries/virology ; Disease Models, Animal ; Female ; HIV Infections ; Heme Oxygenase-1/metabolism ; Inflammation ; Macaca mulatta ; Male ; Oxidative Stress ; Protein Isoforms ; Simian Acquired Immunodeficiency Syndrome/pathology ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus/pathogenicity
Czasopismo naukowe
Tytuł :
Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge.
Autorzy :
Om K; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Paquin-Proulx D; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Montero M; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Peachman K; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Shen X; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America.
Wieczorek L; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Beck Z; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Weiner JA; Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, United States of America.
Kim D; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Li Y; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Mdluli T; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Shubin Z; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Bryant C; EMMES, Rockville, Maryland, United States of America.
Sharma V; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Tokarev A; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Dawson P; EMMES, Rockville, Maryland, United States of America.
White Y; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Appelbe O; Department of Pharmaceutics, University of Washington, Seattle, Washington, United States of America.
Klatt NR; Department of Pharmaceutics, University of Washington, Seattle, Washington, United States of America.
Tovanabutra S; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Estes JD; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, United States of America.
Matyas GR; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Ferrari G; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America.
Alving CR; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Tomaras GD; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America.
Ackerman ME; Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, United States of America.
Michael NL; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Robb ML; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Polonis V; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Rolland M; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Eller MA; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Rao M; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Bolton DL; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Sep 03; Vol. 16 (9), pp. e1008764. Date of Electronic Publication: 2020 Sep 03 (Print Publication: 2020).
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Adjuvants, Immunologic/*administration & dosage
Antibodies, Viral/*immunology
Antibody Formation/*immunology
HIV Antibodies/*immunology
HIV Infections/*prevention & control
SAIDS Vaccines/*therapeutic use
Simian Acquired Immunodeficiency Syndrome/*prevention & control
Adolescent ; Adult ; Animals ; Antibodies, Neutralizing/immunology ; Double-Blind Method ; Female ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/drug effects ; HIV-1/immunology ; Humans ; Macaca mulatta ; Male ; Middle Aged ; SAIDS Vaccines/immunology ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus/drug effects ; Simian Immunodeficiency Virus/immunology ; Young Adult
Czasopismo naukowe
Tytuł :
Origin of rebound virus in chronically SIV-infected Rhesus monkeys following treatment discontinuation.
Autorzy :
Liu PT; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Keele BF; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Abbink P; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Mercado NB; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Liu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Bondzie EA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Chandrashekar A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Borducchi EN; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Hesselgesser J; Gilead Sciences, Foster City, CA, USA.
Mish M; Gilead Sciences, Foster City, CA, USA.
Chin G; Gilead Sciences, Foster City, CA, USA.
Bekerman E; Gilead Sciences, Foster City, CA, USA.
Geleziunas R; Gilead Sciences, Foster City, CA, USA.
Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. .; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 27; Vol. 11 (1), pp. 5412. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Retroviral Agents/*administration & dosage
Simian Acquired Immunodeficiency Syndrome/*drug therapy
Simian Immunodeficiency Virus/*physiology
Animals ; CD4-Positive T-Lymphocytes/virology ; Female ; HIV Infections/drug therapy ; HIV Infections/virology ; HIV-1/drug effects ; HIV-1/genetics ; HIV-1/physiology ; Humans ; Macaca mulatta ; Male ; Patient Dropouts ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus/drug effects ; Simian Immunodeficiency Virus/genetics ; Viral Load/drug effects ; Virus Latency/drug effects ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans.
Autorzy :
Nakano Y; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Yamamoto K; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ueda MT; Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan.
Soper A; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Konno Y; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.; Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Kimura I; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Uriu K; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.; Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Kumata R; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.; Faculty of Science, Kyoto University, Kyoto, Japan.
Aso H; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Misawa N; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Nagaoka S; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.; Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Shimizu S; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Mitsumune K; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Kosugi Y; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Juarez-Fernandez G; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ito J; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.
Nakagawa S; Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan.
Ikeda T; Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America.; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, Minnesota, United States of America.; Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
Koyanagi Y; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Harris RS; Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America.; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, Minnesota, United States of America.
Sato K; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.; CREST, Japan Science and Technology Agency, Saitama, Japan.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Sep 10; Vol. 16 (9), pp. e1008812. Date of Electronic Publication: 2020 Sep 10 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Evolution, Molecular*
Host-Pathogen Interactions*
Virus Replication*
APOBEC-3G Deaminase/*metabolism
Gene Products, vif/*metabolism
Simian Acquired Immunodeficiency Syndrome/*transmission
Simian Immunodeficiency Virus/*isolation & purification
APOBEC-3G Deaminase/chemistry ; APOBEC-3G Deaminase/genetics ; Amino Acid Sequence ; Animals ; Gene Products, vif/chemistry ; Gene Products, vif/genetics ; Gorilla gorilla ; Humans ; Pan troglodytes ; Phylogeny ; Protein Conformation ; Sequence Homology ; Simian Acquired Immunodeficiency Syndrome/virology
Czasopismo naukowe
Tytuł :
Early exposure to broadly neutralizing antibodies may trigger a dynamical switch from progressive disease to lasting control of SHIV infection.
Autorzy :
Desikan R; Department of Chemical Engineering, Indian Institute of Science, Bengaluru, India.
Raja R; Department of Chemical Engineering, Indian Institute of Science, Bengaluru, India.
Dixit NM; Department of Chemical Engineering, Indian Institute of Science, Bengaluru, India.; Centre for Biosystems Science and Engineering, Indian Institute of Science, Bengaluru, India.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2020 Aug 20; Vol. 16 (8), pp. e1008064. Date of Electronic Publication: 2020 Aug 20 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Broadly Neutralizing Antibodies/*immunology
HIV Infections/*immunology
Simian Acquired Immunodeficiency Syndrome/*immunology
Animals ; HIV Infections/virology ; Humans ; Macaca mulatta ; Simian Acquired Immunodeficiency Syndrome/virology ; Viral Load ; Viremia/immunology
Czasopismo naukowe
Tytuł :
The Brain Retains: Nonhuman Primate Models for Pediatric HIV-1 in the CNS.
Autorzy :
Obregon-Perko V; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Bricker K; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Chahroudi A; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. .; Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. .; Emory+Children's Center for Childhood Infections and Vaccines, Atlanta, GA, USA. .
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Źródło :
Current HIV/AIDS reports [Curr HIV/AIDS Rep] 2020 Aug; Vol. 17 (4), pp. 343-353.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Blood-Brain Barrier/*physiology
Brain/*pathology
HIV Infections/*pathology
Myeloid Cells/*virology
Simian Acquired Immunodeficiency Syndrome/*pathology
Animals ; Anti-HIV Agents/therapeutic use ; Brain/virology ; CD4-Positive T-Lymphocytes/virology ; Cerebrospinal Fluid/virology ; Child ; Cognitive Dysfunction/virology ; Disease Models, Animal ; Encephalitis/virology ; HIV Infections/drug therapy ; HIV Seropositivity ; HIV-1/drug effects ; Humans ; Infectious Disease Transmission, Vertical ; Macaca ; Simian Acquired Immunodeficiency Syndrome/drug therapy ; Simian Immunodeficiency Virus/drug effects
Czasopismo naukowe
Tytuł :
Therapeutic Efficacy and Resistance Selection of a Lipopeptide Fusion Inhibitor in Simian Immunodeficiency Virus-Infected Rhesus Macaques.
Autorzy :
Yu D; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xue J; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wei H; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Cong Z; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chen T; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhu Y; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chong H; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wei Q; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Qin C; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
He Y; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China .; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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Źródło :
Journal of virology [J Virol] 2020 Jul 16; Vol. 94 (15). Date of Electronic Publication: 2020 Jul 16 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Simian Acquired Immunodeficiency Syndrome*/drug therapy
Simian Acquired Immunodeficiency Syndrome*/genetics
Simian Acquired Immunodeficiency Syndrome*/metabolism
Simian Acquired Immunodeficiency Syndrome*/pathology
Lipopeptides/*pharmacology
Lipoproteins/*pharmacology
Simian Immunodeficiency Virus/*metabolism
Viral Fusion Proteins/*metabolism
Virus Internalization/*drug effects
Amino Acid Substitution ; Animals ; Lipopeptides/chemistry ; Lipoproteins/chemistry ; Macaca mulatta ; Mutation, Missense ; Simian Immunodeficiency Virus/genetics ; Viral Fusion Proteins/genetics
Czasopismo naukowe
Tytuł :
Therapeutic vaccine-mediated Gag-specific CD8 cells in simian immunodeficiency virus-infected macaques.
Autorzy :
Nakamura-Hoshi M; AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.; The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
Takahara Y; AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.; The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
Matsuoka S; AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
Ishii H; AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
Seki S; AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
Nomura T; AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
Yamamoto H; AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
Sakawaki H; Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Miura T; Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Tokusumi T; ID Pharma Co., Ltd., 6 Ohkubo, Tsukuba, Ibaraki, 300-2611, Japan.
Shu T; ID Pharma Co., Ltd., 6 Ohkubo, Tsukuba, Ibaraki, 300-2611, Japan.
Matano T; AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan. .; The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 09; Vol. 10 (1), pp. 11394. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acquired Immunodeficiency Syndrome/*therapy
Anti-Retroviral Agents/*pharmacology
CD8-Positive T-Lymphocytes/*immunology
SAIDS Vaccines/*administration & dosage
Simian Acquired Immunodeficiency Syndrome/*therapy
Acquired Immunodeficiency Syndrome/immunology ; Acquired Immunodeficiency Syndrome/virology ; Animals ; Anti-Retroviral Agents/therapeutic use ; CD8-Positive T-Lymphocytes/drug effects ; Disease Models, Animal ; Gene Products, gag/immunology ; Gene Products, vif/immunology ; Humans ; Immunogenicity, Vaccine ; Macaca mulatta ; SAIDS Vaccines/immunology ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus/immunology ; Viral Load/drug effects ; Viral Load/immunology
Czasopismo naukowe
Tytuł :
Polyethylene Glycol 40-Modified Peptide with High Therapeutic Efficacy in Simian-Human Immunodeficiency Virus-Acutely Infected Rhesus Monkeys.
Autorzy :
Li M; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Huairou District, Beijing, China.
Cheng S; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Huairou District, Beijing, China.
Ding Y; State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Changping District, Beijing, China.
Wang C; State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Changping District, Beijing, China.
Feng Y; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Huairou District, Beijing, China.
Wang W; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China.
Ma L; State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Changping District, Beijing, China .
Li X; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China .; Savaid Medical School, University of Chinese Academy of Sciences, Huairou District, Beijing, China.
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Źródło :
Journal of virology [J Virol] 2020 Jul 01; Vol. 94 (14). Date of Electronic Publication: 2020 Jul 01 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV Envelope Protein gp41*/chemistry
HIV Envelope Protein gp41*/pharmacokinetics
HIV Envelope Protein gp41*/pharmacology
HIV Fusion Inhibitors*/chemistry
HIV Fusion Inhibitors*/pharmacokinetics
HIV Fusion Inhibitors*/pharmacology
HIV Infections*/drug therapy
HIV Infections*/metabolism
HIV Infections*/pathology
Peptide Fragments*/chemistry
Peptide Fragments*/pharmacokinetics
Peptide Fragments*/pharmacology
Simian Acquired Immunodeficiency Syndrome*/drug therapy
Simian Acquired Immunodeficiency Syndrome*/metabolism
Simian Acquired Immunodeficiency Syndrome*/pathology
HIV-1/*metabolism
Polyethylene Glycols/*chemistry
Simian Immunodeficiency Virus/*metabolism
Animals ; Humans ; Macaca mulatta
Czasopismo naukowe
Tytuł :
Virologic and Immunologic Features of Simian Immunodeficiency Virus Control Post-ART Interruption in Rhesus Macaques.
Autorzy :
Strongin Z; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Micci L; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Fromentin R; Centre de recherche du CHUM, Montreal, Quebec, Canada.; Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Quebec, Canada.
Harper J; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
McBrien J; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Ryan E; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Shenvi N; Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Easley K; Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Chomont N; Centre de recherche du CHUM, Montreal, Quebec, Canada.; Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Quebec, Canada.
Silvestri G; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Paiardini M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA .; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
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Źródło :
Journal of virology [J Virol] 2020 Jul 01; Vol. 94 (14). Date of Electronic Publication: 2020 Jul 01 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Simian Acquired Immunodeficiency Syndrome*/blood
Simian Acquired Immunodeficiency Syndrome*/drug therapy
Simian Acquired Immunodeficiency Syndrome*/immunology
Simian Immunodeficiency Virus*/immunology
Simian Immunodeficiency Virus*/metabolism
Th17 Cells*/immunology
Th17 Cells*/metabolism
Anti-Retroviral Agents/*pharmacology
Animals ; CD4-CD8 Ratio ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; DNA, Viral/blood ; DNA, Viral/immunology ; Macaca mulatta ; Time Factors
Czasopismo naukowe
Tytuł :
The colonic mucosa-associated microbiome in SIV infection: shift towards Bacteroidetes coincides with mucosal CD4 T cell depletion and enterocyte damage.
Autorzy :
Allers K; Department of Gastroenterology, Infectious Diseases, and Rheumatology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany. .
Stahl-Hennig C; German Primate Center, 37077, Göttingen, Germany.
Fiedler T; Institute of Medical Microbiology, Virology, and Hygiene, Rostock University Medical Centre, 18057, Rostock, Germany.
Wibberg D; Center for Biotechnology (CeBiTec), Bielefeld University, 33615, Bielefeld, Germany.
Hofmann J; Institute of Medical Virology, Charité-Universitätsmedizin Berlin, Campus Mitte, 10117, Berlin, Germany.
Kunkel D; Department of Gastroenterology, Infectious Diseases, and Rheumatology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.; Berlin-Brandenburg Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, 13353, Berlin, Germany.
Moos V; Department of Gastroenterology, Infectious Diseases, and Rheumatology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
Kreikemeyer B; Institute of Medical Microbiology, Virology, and Hygiene, Rostock University Medical Centre, 18057, Rostock, Germany.
Kalinowski J; Center for Biotechnology (CeBiTec), Bielefeld University, 33615, Bielefeld, Germany.
Schneider T; Institute of Medical Virology, Charité-Universitätsmedizin Berlin, Campus Mitte, 10117, Berlin, Germany.
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 02; Vol. 10 (1), pp. 10887. Date of Electronic Publication: 2020 Jul 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gastrointestinal Microbiome*
Bacteroidetes/*isolation & purification
CD4-Positive T-Lymphocytes/*immunology
Enterocytes/*pathology
Intestinal Mucosa/*microbiology
Simian Acquired Immunodeficiency Syndrome/*microbiology
Animals ; Bacterial Translocation ; Bacteroidetes/classification ; CD4 Lymphocyte Count ; Firmicutes/isolation & purification ; Helicobacter/isolation & purification ; Intestinal Mucosa/pathology ; Macaca mulatta ; Ribotyping ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Immunodeficiency Virus/genetics ; Simian Immunodeficiency Virus/isolation & purification ; Viral Load
Czasopismo naukowe
Tytuł :
Mucosal-associated invariant T (MAIT) cells provide B-cell help in vaccinated and subsequently SIV-infected Rhesus Macaques.
Autorzy :
Rahman MA; Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Ko EJ; Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.; College of Veterinary Medicine and Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju, 63243, Korea.
Bhuyan F; Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Enyindah-Asonye G; Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Hunegnaw R; Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Helmold Hait S; Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Hogge CJ; Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Venzon DJ; Biostatistics and Data Management Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Hoang T; Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Robert-Guroff M; Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jun 22; Vol. 10 (1), pp. 10060. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
B-Lymphocytes/*metabolism
Mucosal-Associated Invariant T Cells/*metabolism
Simian Acquired Immunodeficiency Syndrome/*prevention & control
Simian Immunodeficiency Virus/*immunology
Vaccination/*veterinary
Animals ; Bronchoalveolar Lavage Fluid/immunology ; Female ; Interferon-gamma/metabolism ; Ki-67 Antigen/metabolism ; Longitudinal Studies ; Lymphocyte Activation ; Macaca mulatta ; Simian Acquired Immunodeficiency Syndrome/immunology ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
MAIT cells are functionally impaired in a Mauritian cynomolgus macaque model of SIV and Mtb co-infection.
Autorzy :
Ellis AL; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Balgeman AJ; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Larson EC; Department of Microbiology and Molecular Genetics, and Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Rodgers MA; Department of Microbiology and Molecular Genetics, and Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Ameel C; Department of Microbiology and Molecular Genetics, and Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Baranowski T; Department of Microbiology and Molecular Genetics, and Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Kannal N; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Maiello P; Department of Microbiology and Molecular Genetics, and Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Juno JA; Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia.
Scanga CA; Department of Microbiology and Molecular Genetics, and Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
O'Connor SL; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 May 20; Vol. 16 (5), pp. e1008585. Date of Electronic Publication: 2020 May 20 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Coinfection/*immunology
Mucosal-Associated Invariant T Cells/*immunology
Mycobacterium tuberculosis/*immunology
Simian Acquired Immunodeficiency Syndrome/*immunology
Simian Immunodeficiency Virus/*immunology
Tuberculosis, Pulmonary/*immunology
Animals ; Coinfection/pathology ; Granuloma/immunology ; Granuloma/pathology ; Lymph Nodes/immunology ; Lymph Nodes/pathology ; Macaca fascicularis ; Mucosal-Associated Invariant T Cells/pathology ; Programmed Cell Death 1 Receptor/immunology ; Receptors, Immunologic/immunology ; Simian Acquired Immunodeficiency Syndrome/pathology ; Tuberculosis, Pulmonary/pathology
Czasopismo naukowe
Tytuł :
Differential Outcomes following Optimization of Simian-Human Immunodeficiency Viruses from Clades AE, B, and C.
Autorzy :
Tartaglia LJ; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Gupte S; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Pastores KC; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Trott S; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Abbink P; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Mercado NB; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Li Z; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Liu PT; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Borducchi EN; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Chandrashekar A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Bondzie EA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Hamza V; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Kordana N; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Mahrokhian S; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Lavine CL; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Li H; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Shaw GM; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA .; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.
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Źródło :
Journal of virology [J Virol] 2020 May 04; Vol. 94 (10). Date of Electronic Publication: 2020 May 04 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Simian Acquired Immunodeficiency Syndrome/*immunology
Simian Immunodeficiency Virus/*genetics
Simian Immunodeficiency Virus/*immunology
Animals ; Antibodies, Neutralizing ; CD4-Positive T-Lymphocytes ; Female ; Gene Products, env/genetics ; HIV Infections/virology ; HIV-1/genetics ; HIV-1/immunology ; Humans ; Macaca mulatta ; Male ; Mutation ; Sequence Analysis ; Simian Acquired Immunodeficiency Syndrome/virology ; Viral Load ; Virus Replication
Czasopismo naukowe
Tytuł :
Simian Immunodeficiency Virus-Infected Memory CD4 T Cells Infiltrate to the Site of Infected Macrophages in the Neuroparenchyma of a Chronic Macaque Model of Neurological Complications of AIDS.
Autorzy :
Lee CA; Laboratory of Molecular Microbiology, NIAID/NIH, Bethesda, Maryland, USA.
Beasley E; Laboratory of Molecular Microbiology, NIAID/NIH, Bethesda, Maryland, USA.
Sundar K; Laboratory of Molecular Microbiology, NIAID/NIH, Bethesda, Maryland, USA.
Smelkinson M; Biological Imaging, Research Technology Branch, NIAID/NIH, Bethesda, Maryland, USA.
Vinton C; Laboratory of Viral Diseases, NIAID/NIH, Bethesda, Maryland, USA.
Deleage C; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Matsuda K; Laboratory of Molecular Microbiology, NIAID/NIH, Bethesda, Maryland, USA.
Wu F; Laboratory of Molecular Microbiology, NIAID/NIH, Bethesda, Maryland, USA.
Estes JD; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center (ONPRC), Oregon Health and Science University (OHSU), Beaverton, Oregon, USA.
Lafont BAP; Viral Immunology Section, Office of the Scientific Director, NIAID/NIH, Bethesda, Maryland, USA.
Brenchley JM; Laboratory of Viral Diseases, NIAID/NIH, Bethesda, Maryland, USA.
Hirsch VM; Laboratory of Molecular Microbiology, NIAID/NIH, Bethesda, Maryland, USA .
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Źródło :
MBio [mBio] 2020 Apr 21; Vol. 11 (2). Date of Electronic Publication: 2020 Apr 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms :
CD4-Positive T-Lymphocytes/*immunology
Host-Pathogen Interactions/*immunology
Macrophages/*immunology
Nervous System Diseases/*etiology
Simian Acquired Immunodeficiency Syndrome/*complications
Simian Acquired Immunodeficiency Syndrome/*immunology
Simian Immunodeficiency Virus/*immunology
Animals ; Biomarkers ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/virology ; Central Nervous System/immunology ; Central Nervous System/pathology ; Central Nervous System/virology ; Disease Models, Animal ; Fluorescent Antibody Technique ; Immunohistochemistry ; Immunophenotyping ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/virology ; Macrophages/metabolism ; Macrophages/virology ; Nervous System Diseases/pathology ; Neuroimmunomodulation ; Simian Acquired Immunodeficiency Syndrome/virology ; Viral Load ; Virulence
Czasopismo naukowe
Tytuł :
Presence of Inflammatory Group I and III Innate Lymphoid Cells in the Colon of Simian Immunodeficiency Virus-Infected Rhesus Macaques.
Autorzy :
Cogswell A; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USA.
Ferguson N; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USA.
Barker E; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USA .
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Źródło :
Journal of virology [J Virol] 2020 Apr 16; Vol. 94 (9). Date of Electronic Publication: 2020 Apr 16 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Lymphocytes/*immunology
Simian Acquired Immunodeficiency Syndrome/*immunology
Simian Immunodeficiency Virus/*metabolism
Animals ; Colon/immunology ; Cytokines/immunology ; Female ; Immunity, Innate/immunology ; Inflammation/pathology ; Interferon-gamma/metabolism ; Interleukin-17/metabolism ; Interleukins/metabolism ; Intestinal Mucosa/virology ; Killer Cells, Natural/metabolism ; Lymphocytes/metabolism ; Macaca mulatta/virology ; Male ; Simian Acquired Immunodeficiency Syndrome/metabolism ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus/pathogenicity ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe

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