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Wyszukujesz frazę ""Simvastatin"" wg kryterium: Temat


Tytuł :
Simvastatin can enhance the osseointegration of titanium rods in ovariectomized rats maintenance treatment with valproic acid.
Autorzy :
Tao ZS; Department of Trauma Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, No. 2, Zhe Shan Xi Road, Wuhu 241001, Anhui, People's Republic of China.
Zhou WS; Department of Geriatrics, the Second Affiliated Hospital of Wannan Medical College, No.123, Kangfu Road, Wuhu 241000, Anhui, People's Republic of China.
Xu HG; Department of Spinal Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, No. 2, Zhe Shan Xi Road, Wuhu 241001, Anhui, People's Republic of China.
Yang M; Department of Trauma Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, No. 2, Zhe Shan Xi Road, Wuhu 241001, Anhui, People's Republic of China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Dec; Vol. 132, pp. 110745. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article
MeSH Terms :
Osteoporosis/*therapy
Simvastatin/*pharmacology
Titanium/*chemistry
Valproic Acid/*toxicity
3T3 Cells ; Animals ; Anticonvulsants/administration & dosage ; Anticonvulsants/toxicity ; Female ; Gene Expression Regulation ; Mice ; Osseointegration/drug effects ; Osteogenesis/drug effects ; Osteoporosis/genetics ; Osteoporosis/pathology ; Ovariectomy ; Prostheses and Implants ; Prosthesis Design ; Rats ; Rats, Sprague-Dawley ; Simvastatin/administration & dosage ; Valproic Acid/administration & dosage ; X-Ray Microtomography
Czasopismo naukowe
Tytuł :
Transgenerational inheritance of chemical-induced signature: A case study with simvastatin.
Autorzy :
Neuparth T; CIMAR/CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal. Electronic address: .
Machado AM; CIMAR/CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal; FCUP - Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal.
Montes R; Department of Analytical Chemistry, Nutrition and Food Sciences, IAQBUS - Institute of Research on Chemical and Biological Analysis, Universidade de Santiago de Compostela, R. Constantino Candeira S/N, 15782 Santiago de Compostela, Spain.
Rodil R; Department of Analytical Chemistry, Nutrition and Food Sciences, IAQBUS - Institute of Research on Chemical and Biological Analysis, Universidade de Santiago de Compostela, R. Constantino Candeira S/N, 15782 Santiago de Compostela, Spain.
Barros S; CIMAR/CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.
Alves N; CIMAR/CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.
Ruivo R; CIMAR/CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.
Castro LFC; CIMAR/CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal; FCUP - Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal.
Quintana JB; Department of Analytical Chemistry, Nutrition and Food Sciences, IAQBUS - Institute of Research on Chemical and Biological Analysis, Universidade de Santiago de Compostela, R. Constantino Candeira S/N, 15782 Santiago de Compostela, Spain.
Santos MM; CIMAR/CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal; FCUP - Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal. Electronic address: .
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Źródło :
Environment international [Environ Int] 2020 Nov; Vol. 144, pp. 106020. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amphipoda*
Simvastatin*/toxicity
Animals ; Epigenesis, Genetic ; Humans ; Reproduction
Czasopismo naukowe
Tytuł :
Effects of multidose simvastatin co-administration on pharmacokinetic profile of apatinib in rats by UPLC-MS/MS.
Autorzy :
Gao J; Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Ren H; Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Feng Z; Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Chen S; Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Liang Y; Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Liu W; Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Zhou Q; Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Wang M; Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Sep; Vol. 50 (9), pp. 1115-1120. Date of Electronic Publication: 2020 Mar 19.
Typ publikacji :
Journal Article
MeSH Terms :
Pyridines/*pharmacokinetics
Simvastatin/*pharmacokinetics
Animals ; Area Under Curve ; Chromatography, Liquid ; Cytochrome P-450 CYP3A ; Protein Kinase Inhibitors ; Pyridines/administration & dosage ; Rats ; Rats, Sprague-Dawley ; Simvastatin/administration & dosage
Czasopismo naukowe
Tytuł :
Simvastatin improves mitochondrial respiration in peripheral blood cells.
Autorzy :
Durhuus JA; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.; The HNPCC Register, Clinical Research Center, Copenhagen University Hospital, Hvidovre, Denmark.
Hansson S; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Morville T; Department of Biomedical Sciences, XLAB, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Kuhlman AB; Department of Biomedical Sciences, XLAB, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Dohlmann TL; Department of Biomedical Sciences, XLAB, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Larsen S; Department of Biomedical Sciences, XLAB, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.; Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland.
Helge JW; Department of Biomedical Sciences, XLAB, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Angleys M; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Muniesa-Vargas A; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Bundgaard JR; Department of Clinical Biochemistry, University of Copenhagen, Copenhagen, Denmark.
Hickson ID; Department of Cellular and Molecular Medicine, Center for Healthy Aging, Center for Chromosome Stability, University of Copenhagen, Copenhagen, Denmark.
Dela F; Department of Biomedical Sciences, XLAB, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.; Department of Geriatrics, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark.
Desler C; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark. .
Rasmussen LJ; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark. .
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Źródło :
Scientific reports [Sci Rep] 2020 Oct 12; Vol. 10 (1), pp. 17012. Date of Electronic Publication: 2020 Oct 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood Platelets/*drug effects
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology
Hypercholesterolemia/*drug therapy
Leukocytes, Mononuclear/*drug effects
Mitochondria/*drug effects
Simvastatin/*pharmacology
Blood Platelets/metabolism ; Cell Line ; Electron Transport Complex I/metabolism ; Electron Transport Complex IV/metabolism ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hypercholesterolemia/metabolism ; Leukocytes, Mononuclear/metabolism ; Male ; Middle Aged ; Mitochondria/metabolism ; Oxygen Consumption/drug effects ; Simvastatin/therapeutic use ; Superoxides/metabolism
Czasopismo naukowe
Tytuł :
Effect of Switching from Low-Dose Simvastatin to High-Dose Atorvastatin on Glucose Homeostasis and Cognitive Function in Type 2 Diabetes.
Autorzy :
Thongtang N; Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Tangkittikasem N; Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Samaithongcharoen K; Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Piyapromdee J; Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Srinonprasert V; Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Sriussadaporn S; Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
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Źródło :
Vascular health and risk management [Vasc Health Risk Manag] 2020 Sep 21; Vol. 16, pp. 367-377. Date of Electronic Publication: 2020 Sep 21 (Print Publication: 2020).
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Drug Substitution*
Atorvastatin/*administration & dosage
Blood Glucose/*drug effects
Cognition/*drug effects
Diabetes Mellitus, Type 2/*drug therapy
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage
Simvastatin/*administration & dosage
Aged ; Atorvastatin/adverse effects ; Biomarkers/blood ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/psychology ; Female ; Glycated Hemoglobin A/metabolism ; Homeostasis ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Male ; Mental Status and Dementia Tests ; Middle Aged ; Simvastatin/adverse effects ; Thailand ; Time Factors ; Trail Making Test ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Enhancing the Hypolipidemic Effect of Simvastatin in Poloxamer-Induced Hyperlipidemic Rats via Liquisolid Approach: Pharmacokinetic and Pharmacodynamic Evaluation.
Autorzy :
El-Say KM; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. .; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt. .
Ahmed TA; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Ahmed OAA; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Minia University, Minya, Egypt.
Elimam H; Department of Biochemistry, Faculty of Pharmacy, University of Sadat City, Sadat City, Monufia, Egypt.
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Źródło :
AAPS PharmSciTech [AAPS PharmSciTech] 2020 Aug 04; Vol. 21 (6), pp. 223. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article
MeSH Terms :
Hypolipidemic Agents/*pharmacology
Simvastatin/*pharmacology
Animals ; Biological Availability ; Male ; Poloxamer/toxicity ; Rats ; Rats, Wistar ; Simvastatin/chemistry ; Simvastatin/pharmacokinetics ; Solubility ; Tablets
Czasopismo naukowe
Tytuł :
Modified electrospun chitosan membranes for controlled release of simvastatin.
Autorzy :
Murali VP; Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, USA. Electronic address: .
Fujiwara T; Department of Chemistry, University of Memphis, Memphis, TN 38152, USA.
Gallop C; Department of Chemistry, University of Memphis, Memphis, TN 38152, USA.
Wang Y; Department of Chemistry, University of Memphis, Memphis, TN 38152, USA.
Wilson JA; Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, USA.
Atwill MT; Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, USA.
Kurakula M; Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, USA.
Bumgardner JD; Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, USA.
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2020 Jun 30; Vol. 584, pp. 119438. Date of Electronic Publication: 2020 May 17.
Typ publikacji :
Journal Article
MeSH Terms :
Chitosan*/administration & dosage
Chitosan*/chemistry
Hydroxymethylglutaryl-CoA Reductase Inhibitors*/administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors*/chemistry
Membranes, Artificial*
Nanofibers*/administration & dosage
Nanofibers*/chemistry
Simvastatin*/administration & dosage
Simvastatin*/chemistry
Acylation ; Animals ; Cell Line ; Cell Survival/drug effects ; Delayed-Action Preparations/administration & dosage ; Delayed-Action Preparations/chemistry ; Fatty Acids/chemistry ; Mice
Czasopismo naukowe
Tytuł :
Simvastatin induces adverse effects on proliferation and mineralization of human primary osteoblasts.
Autorzy :
Sabandal MMI; Central Interdisciplinary Ambulance in the School of Dentistry, University of Münster, Albert-Schweitzer-Campus 1, Gebäude W30, Waldeyerstr. 30, 48149, Münster, Germany. .
Schäfer E; Central Interdisciplinary Ambulance in the School of Dentistry, University of Münster, Albert-Schweitzer-Campus 1, Gebäude W30, Waldeyerstr. 30, 48149, Münster, Germany.
Aed J; Central Interdisciplinary Ambulance in the School of Dentistry, University of Münster, Albert-Schweitzer-Campus 1, Gebäude W30, Waldeyerstr. 30, 48149, Münster, Germany.; Department of Cranio-Maxillofacial Surgery, University Hospital Münster, Münster, Germany.
Jung S; Department of Cranio-Maxillofacial Surgery, University Hospital Münster, Münster, Germany.
Kleinheinz J; Department of Cranio-Maxillofacial Surgery, University Hospital Münster, Münster, Germany.
Sielker S; Department of Cranio-Maxillofacial Surgery, University Hospital Münster, Münster, Germany.
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Źródło :
Head & face medicine [Head Face Med] 2020 Aug 20; Vol. 16 (1), pp. 18. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article
MeSH Terms :
Anticholesteremic Agents*/adverse effects
Osteoblasts*/drug effects
Osteogenesis*/drug effects
Simvastatin*/adverse effects
Adult ; Cell Differentiation ; Cell Proliferation ; Female ; Humans ; Male
Czasopismo naukowe
Tytuł :
Formulation of simvastatin chitosan nanoparticles for controlled delivery in bone regeneration: Optimization using Box-Behnken design, stability and in vivo study.
Autorzy :
Delan WK; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr el Aini Street, Cairo, Egypt.
Zakaria M; Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University, Kasr Al Aini Street, Cairo, Egypt.
Elsaadany B; Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University, Kasr Al Aini Street, Cairo, Egypt.
ElMeshad AN; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr el Aini Street, Cairo, Egypt.
Mamdouh W; Department of Chemistry, School of Sciences and Engineering, The American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo 11835, Egypt.
Fares AR; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr el Aini Street, Cairo, Egypt. Electronic address: .
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2020 Mar 15; Vol. 577, pp. 119038. Date of Electronic Publication: 2020 Jan 15.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Regeneration/*drug effects
Chitosan/*analogs & derivatives
Drug Compounding/*methods
Nanoparticles/*chemistry
Simvastatin/*chemistry
Administration, Oral ; Animals ; Biological Availability ; Bone Density/drug effects ; Chitosan/chemistry ; Cone-Beam Computed Tomography ; Drug Carriers/chemistry ; Drug Carriers/pharmacology ; Drug Liberation ; Drug Stability ; Male ; Microscopy, Electron, Transmission ; Particle Size ; Rabbits ; Simvastatin/pharmacokinetics ; Simvastatin/pharmacology ; Surface Properties
Czasopismo naukowe
Tytuł :
Stent coating by electrospinning with chitosan/poly-cyclodextrin based nanofibers loaded with simvastatin for restenosis prevention.
Autorzy :
Kersani D; Univ. Lille, CNRS UMR8207, UMET - Unité Matériaux et Transformations, F-59655 Villeneuve D'Ascq, France.
Mougin J; Univ. Lille, INSERM, CHU Lille, U1008 - Controlled Drug Delivery Systems and Biomaterials, F-59000 Lille, France.
Lopez M; Univ. Lille, INSERM, CHU Lille, U1008 - Controlled Drug Delivery Systems and Biomaterials, F-59000 Lille, France.
Degoutin S; Univ. Lille, CNRS UMR8207, UMET - Unité Matériaux et Transformations, F-59655 Villeneuve D'Ascq, France.
Tabary N; Univ. Lille, CNRS UMR8207, UMET - Unité Matériaux et Transformations, F-59655 Villeneuve D'Ascq, France.
Cazaux F; Univ. Lille, CNRS UMR8207, UMET - Unité Matériaux et Transformations, F-59655 Villeneuve D'Ascq, France.
Janus L; Univ. Lille, CNRS UMR8207, UMET - Unité Matériaux et Transformations, F-59655 Villeneuve D'Ascq, France.
Maton M; Univ. Lille, INSERM, CHU Lille, U1008 - Controlled Drug Delivery Systems and Biomaterials, F-59000 Lille, France.
Chai F; Univ. Lille, INSERM, CHU Lille, U1008 - Controlled Drug Delivery Systems and Biomaterials, F-59000 Lille, France.
Sobocinski J; Univ. Lille, INSERM, CHU Lille, U1008 - Controlled Drug Delivery Systems and Biomaterials, F-59000 Lille, France.
Blanchemain N; Univ. Lille, INSERM, CHU Lille, U1008 - Controlled Drug Delivery Systems and Biomaterials, F-59000 Lille, France.
Martel B; Univ. Lille, CNRS UMR8207, UMET - Unité Matériaux et Transformations, F-59655 Villeneuve D'Ascq, France. Electronic address: .
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Źródło :
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2020 May; Vol. 150, pp. 156-167. Date of Electronic Publication: 2020 Mar 13.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Drug Carriers*
Drug-Eluting Stents*
Nanofibers*
Self Expandable Metallic Stents*
Angioplasty/*instrumentation
Chitosan/*chemistry
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*chemistry
Simvastatin/*chemistry
beta-Cyclodextrins/*chemistry
Alloys ; Delayed-Action Preparations ; Drug Compounding ; Drug Liberation ; Kinetics ; Models, Chemical ; Prosthesis Design ; Simvastatin/administration & dosage ; Solubility ; Surface Properties
Czasopismo naukowe
Tytuł :
Chitosan Coated Microparticles Enhance Simvastatin Colon Targeting and Pro-Apoptotic Activity.
Autorzy :
Alhakamy NA; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Center of Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Advanced Drug Delivery Research Group, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Fahmy UA; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Ahmed OAA; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Caruso G; Oasi Research Institute-IRCCS, Via Conte Ruggero, 73, 94018 Troina (EN), Italy.
Caraci F; Oasi Research Institute-IRCCS, Via Conte Ruggero, 73, 94018 Troina (EN), Italy.; Department of Drug Sciences, University of Catania, 95125 Catania, Italy.
Asfour HZ; Department of Medical Microbiology and Parasitology, Faculty of Medicine, Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Bakhrebah MA; Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), P.O. Box 6086, Riyadh 11442, Saudi Arabia.
N Alomary M; Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), P.O. Box 6086, Riyadh 11442, Saudi Arabia.
Abdulaal WH; Department of Biochemistry, Cancer Metabolism and Epigenetic Unit, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Okbazghi SZ; Global Analytical and Pharmaceutical Development, Alexion Pharmaceuticals, New Haven, CT 06510, USA.
Abdel-Naim AB; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Eid BG; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Aldawsari HM; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Kurakula M; Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, USA.
Mohamed AI; Department of Pharmaceutics and Industrial Pharmacy, Military Medical Academy, Cairo 11435, Egypt.
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Źródło :
Marine drugs [Mar Drugs] 2020 Apr 24; Vol. 18 (4). Date of Electronic Publication: 2020 Apr 24.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems*
Antineoplastic Agents/*administration & dosage
Chitosan/*chemistry
Colonic Neoplasms/*drug therapy
Simvastatin/*administration & dosage
Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Drug Carriers/chemistry ; HCT116 Cells ; Humans ; Hydrogen-Ion Concentration ; Male ; Microspheres ; Particle Size ; Polymethacrylic Acids/chemistry ; Rabbits ; Simvastatin/pharmacology
Czasopismo naukowe
Tytuł :
Preparation, Physicochemical Characterisation and DoE Optimisation of a Spray-Dried Dry Emulsion Platform for Delivery of a Poorly Soluble Drug, Simvastatin.
Autorzy :
Pohlen M; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia.
Lavrič Z; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia.
Prestidge C; School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.
Dreu R; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia. .
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Źródło :
AAPS PharmSciTech [AAPS PharmSciTech] 2020 Apr 21; Vol. 21 (4), pp. 119. Date of Electronic Publication: 2020 Apr 21.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems/*methods
Emulsions/*chemical synthesis
Simvastatin/*chemical synthesis
Technology, Pharmaceutical/*methods
Chemical Phenomena ; Desiccation/methods ; Drug Stability ; Emulsions/administration & dosage ; Glycerides/administration & dosage ; Glycerides/chemical synthesis ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/chemical synthesis ; Particle Size ; Polysorbates/administration & dosage ; Polysorbates/chemical synthesis ; Simvastatin/administration & dosage ; Solubility ; Tablets
Czasopismo naukowe
Tytuł :
Lysophosphatidic Acid Inhibits Simvastatin-Induced Myocytoxicity by Activating LPA Receptor/PKC Pathway.
Autorzy :
Won KJ; Department of Physiology and Medical Science, School of Medicine, Konkuk University, Chungju 27478, Korea.
Goh YJ; Department of Pharmaceutical Engineering, College of Health Sciences, Sangji University, Wonju 26339, Korea.
Hwang SH; Department of Pharmaceutical Engineering, College of Health Sciences, Sangji University, Wonju 26339, Korea.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Mar 27; Vol. 25 (7). Date of Electronic Publication: 2020 Mar 27.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*adverse effects
Lysophospholipids/*pharmacology
Myoblasts/*drug effects
Protein Kinase C/*metabolism
Receptors, Lysophosphatidic Acid/*antagonists & inhibitors
Simvastatin/*adverse effects
Animals ; Calcium/metabolism ; Caspase 3/metabolism ; Cell Line ; Cell Survival/drug effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Indoles/pharmacology ; Isoxazoles/pharmacology ; Maleimides/pharmacology ; Myoblasts/metabolism ; Propionates/pharmacology ; Protein Kinase C/antagonists & inhibitors ; Rats ; Receptors, Lysophosphatidic Acid/metabolism ; Signal Transduction/drug effects ; Simvastatin/pharmacology ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Influence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits.
Autorzy :
Zhao B; Department of Oral Implantology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266001, People's Republic of China.; School of Stomatology, Qingdao University, Qingdao, Shandong 266001, People's Republic of China.
Li X; Department of Oral Implantology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266001, People's Republic of China.; School of Stomatology, Qingdao University, Qingdao, Shandong 266001, People's Republic of China.
Xu H; Department of Oral Implantology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266001, People's Republic of China.; School of Stomatology, Qingdao University, Qingdao, Shandong 266001, People's Republic of China.
Jiang Y; Department of Oral Implantology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266001, People's Republic of China.; School of Stomatology, Qingdao University, Qingdao, Shandong 266001, People's Republic of China.
Wang D; Department of Oral Implantology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266001, People's Republic of China.; School of Stomatology, Qingdao University, Qingdao, Shandong 266001, People's Republic of China.
Liu R; Department of Oral Implantology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266001, People's Republic of China.; School of Stomatology, Qingdao University, Qingdao, Shandong 266001, People's Republic of China.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2020 Mar 16; Vol. 15, pp. 1797-1807. Date of Electronic Publication: 2020 Mar 16 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Prostheses and Implants*
Osseointegration/*drug effects
Osteoporosis/*pathology
Simvastatin/*pharmacology
Animals ; Bone-Implant Interface ; Coated Materials, Biocompatible/chemistry ; Female ; Hydroxyapatites/chemistry ; Osteogenesis/drug effects ; Oxidation-Reduction ; Rabbits ; Simvastatin/chemistry ; Strontium/chemistry ; Tibia/physiopathology
Czasopismo naukowe
Tytuł :
Simvastatin decreases the silver resistance of E. faecalis through compromising the entrapping function of extracellular polymeric substances against silver.
Autorzy :
Cui J; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‑MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan, 430079, People's Republic of China.
Duan M; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‑MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan, 430079, People's Republic of China.
Sun Q; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‑MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan, 430079, People's Republic of China.
Fan W; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‑MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan, 430079, People's Republic of China. .
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Źródło :
World journal of microbiology & biotechnology [World J Microbiol Biotechnol] 2020 Mar 14; Vol. 36 (4), pp. 54. Date of Electronic Publication: 2020 Mar 14.
Typ publikacji :
Journal Article
MeSH Terms :
Enterococcus faecalis/*drug effects
Silver/*pharmacology
Simvastatin/*pharmacology
Drug Resistance, Bacterial/drug effects ; Enterococcus faecalis/physiology ; Extracellular Polymeric Substance Matrix/drug effects ; Metal Nanoparticles ; Microbial Sensitivity Tests ; Microscopy, Electron, Transmission ; Simvastatin/chemistry
Czasopismo naukowe
Tytuł :
Understanding Concomitant Physical and Chemical Transformations of Simvastatin During Dry Ball Milling.
Autorzy :
Modhave D; Research Center Pharmaceutical Engineering (RCPE) GmbH, Inffeldgasse 13, 8010, Graz, Austria.
Saraf I; Research Center Pharmaceutical Engineering (RCPE) GmbH, Inffeldgasse 13, 8010, Graz, Austria.
Karn A; Research Center Pharmaceutical Engineering (RCPE) GmbH, Inffeldgasse 13, 8010, Graz, Austria.
Paudel A; Research Center Pharmaceutical Engineering (RCPE) GmbH, Inffeldgasse 13, 8010, Graz, Austria. .; Institute for Process and Particle Engineering, Graz University of Technology, Inffeldgasse 13, 8010, Graz, Austria. .
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Źródło :
AAPS PharmSciTech [AAPS PharmSciTech] 2020 May 21; Vol. 21 (5), pp. 152. Date of Electronic Publication: 2020 May 21.
Typ publikacji :
Journal Article
MeSH Terms :
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*chemistry
Simvastatin/*chemistry
Calorimetry, Differential Scanning ; Differential Thermal Analysis ; Drug Compounding ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Light ; Phase Transition ; Powders ; Scattering, Radiation ; Simvastatin/administration & dosage ; Spectrophotometry, Infrared ; X-Rays
Czasopismo naukowe
Tytuł :
Statin Use in the Early Phase of ST-Segment Elevation Myocardial Infarction Is Associated With Decreased QTc Dispersion.
Autorzy :
Munhoz DB; Cardiology Division, Faculty of Medical Sciences, State University of Campinas (Unicamp), Campinas, Sao Paulo, Brazil.
Carvalho LSF; Cardiology Division, Faculty of Medical Sciences, State University of Campinas (Unicamp), Campinas, Sao Paulo, Brazil.
Venancio FNC; Hospital de Base do Distrito Federal, Brasilia, Brazil.; University of Brasilia, Brasilia, Brazil.
Rangel de Almeida OL; Hospital de Base do Distrito Federal, Brasilia, Brazil.
Quinaglia E Silva JC; Hospital de Base do Distrito Federal, Brasilia, Brazil.
Coelho-Filho OR; Cardiology Division, Faculty of Medical Sciences, State University of Campinas (Unicamp), Campinas, Sao Paulo, Brazil.
Nadruz W Jr; Cardiology Division, Faculty of Medical Sciences, State University of Campinas (Unicamp), Campinas, Sao Paulo, Brazil.
Sposito AC; Cardiology Division, Faculty of Medical Sciences, State University of Campinas (Unicamp), Campinas, Sao Paulo, Brazil.
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Źródło :
Journal of cardiovascular pharmacology and therapeutics [J Cardiovasc Pharmacol Ther] 2020 May; Vol. 25 (3), pp. 226-231. Date of Electronic Publication: 2020 Feb 03.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Action Potentials/*drug effects
Anti-Arrhythmia Agents/*administration & dosage
Arrhythmias, Cardiac/*prevention & control
Heart Rate/*drug effects
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage
ST Elevation Myocardial Infarction/*drug therapy
Simvastatin/*administration & dosage
Aged ; Anti-Arrhythmia Agents/adverse effects ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/etiology ; Arrhythmias, Cardiac/physiopathology ; Drug Administration Schedule ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Longitudinal Studies ; Male ; Middle Aged ; Retrospective Studies ; Risk Assessment ; Risk Factors ; ST Elevation Myocardial Infarction/complications ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/physiopathology ; Simvastatin/adverse effects ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Legacy effect of fibrate add-on therapy in diabetic patients with dyslipidemia: a secondary analysis of the ACCORDION study.
Autorzy :
Zhu L; Australian Centre for Public and Population Health Research, Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia. .
Hayen A; Australian Centre for Public and Population Health Research, Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia.
Bell KJL; School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
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Źródło :
Cardiovascular diabetology [Cardiovasc Diabetol] 2020 Mar 05; Vol. 19 (1), pp. 28. Date of Electronic Publication: 2020 Mar 05.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Cardiovascular Diseases/*prevention & control
Diabetes Mellitus, Type 2/*drug therapy
Dyslipidemias/*drug therapy
Fenofibrate/*therapeutic use
Lipids/*blood
Simvastatin/*therapeutic use
Aged ; Biomarkers/blood ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/mortality ; Cause of Death ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/mortality ; Drug Therapy, Combination ; Dyslipidemias/blood ; Dyslipidemias/diagnosis ; Dyslipidemias/mortality ; Female ; Fenofibrate/adverse effects ; Humans ; Male ; Middle Aged ; Risk Factors ; Simvastatin/adverse effects ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
A phase II clinical trial of the Safety Of Simvastatin (SOS) in patients with pulmonary lymphangioleiomyomatosis and with tuberous sclerosis complex.
Autorzy :
Krymskaya VP; Pulmonary, Allergy and Critical Care Division, Department of Medicine, Perelman School of Medicine, Philadelphia, PA, USA.
Courtwright AM; Pulmonary, Allergy and Critical Care Division, Department of Medicine, Perelman School of Medicine, Philadelphia, PA, USA.
Fleck V; Pulmonary, Allergy and Critical Care Division, Department of Medicine, Perelman School of Medicine, Philadelphia, PA, USA.
Dorgan D; Pulmonary, Allergy and Critical Care Division, Department of Medicine, Perelman School of Medicine, Philadelphia, PA, USA.
Kotloff R; Department of Pulmonary Medicine, Cleveland Clinic, Cleveland, OH, USA.
McCormack FX; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA.
Kreider M; Pulmonary, Allergy and Critical Care Division, Department of Medicine, Perelman School of Medicine, Philadelphia, PA, USA. Electronic address: .
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Źródło :
Respiratory medicine [Respir Med] 2020 Mar; Vol. 163, pp. 105898. Date of Electronic Publication: 2020 Feb 08.
Typ publikacji :
Clinical Trial, Phase II; Journal Article
MeSH Terms :
Everolimus/*adverse effects
Lymphangioleiomyomatosis/*drug therapy
Simvastatin/*adverse effects
Tuberous Sclerosis/*drug therapy
Drug Therapy, Combination ; Everolimus/administration & dosage ; Female ; Forced Expiratory Volume ; Humans ; Lymphangioleiomyomatosis/complications ; Lymphangioleiomyomatosis/physiopathology ; Male ; Safety ; Simvastatin/administration & dosage ; Sirolimus/administration & dosage ; Treatment Outcome ; Tuberous Sclerosis/complications ; Tuberous Sclerosis/physiopathology
Czasopismo naukowe
Tytuł :
Calcium Phosphate Carrying Simvastatin Enhances Bone Regeneration: A Systematic Review.
Autorzy :
Cruz R; Laboratory of Dental Clinical Research, Dentistry school, UFF - Universidade Federal Fluminense, Niterói, RJ, Brazil.
Pesce G; Laboratory of Dental Clinical Research, Dentistry school, UFF - Universidade Federal Fluminense, Niterói, RJ, Brazil.
Calasans-Maia J; Department of Orthodontics, Dentistry School, UFF - Universidade Federal Fluminense, Niterói, RJ, Brazil.
Moraschini V; Laboratory of Dental Clinical Research, Dentistry school, UFF - Universidade Federal Fluminense, Niterói, RJ, Brazil.
Calasans-Maia MD; Laboratory of Dental Clinical Research, Dentistry school, UFF - Universidade Federal Fluminense, Niterói, RJ, Brazil.
Granjeiro JM; Laboratory of Dental Clinical Research, Dentistry school, UFF - Universidade Federal Fluminense, Niterói, RJ, Brazil.; Bioengineering Laboratory, INMETRO - Instituto Nacional de Metrologia, Qualidade e Tecnologia, Duque de Caxias, RJ, Brazil.
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Źródło :
Brazilian dental journal [Braz Dent J] 2020 Mar-Apr; Vol. 31 (2), pp. 93-102.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Calcium Phosphates*
Simvastatin*
Animals ; Bone Regeneration ; Bone Transplantation ; Humans ; Osteogenesis
Czasopismo naukowe

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