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Wyszukujesz frazę ""Single-Cell Analysis"" wg kryterium: Temat


Tytuł :
Single-Cell RNA Sequencing Reveals Endothelial Cell Transcriptome Heterogeneity Under Homeostatic Laminar Flow.
Autorzy :
Liu Z; Integrative Program for Biological & Genome Sciences (Z.L., D.L.R., V.L.B.).; McAllister Heart Institute (Z.L., D.L.R., V.L.B.).
Ruter DL; Integrative Program for Biological & Genome Sciences (Z.L., D.L.R., V.L.B.).; Now with KBI Biopharma, Inc, RTP, NC (D.L.R.).; McAllister Heart Institute (Z.L., D.L.R., V.L.B.).; Lineberger Comprehensive Cancer Center (D.L.R., Y.J., V.L.B.).
Quigley K; Department of Chemistry (K.Q.).
Tanke NT; Curriculum in Cell Biology and Physiology (N.T.T., V.L.B.).
Jiang Y; Lineberger Comprehensive Cancer Center (D.L.R., Y.J., V.L.B.).; Department of Biostatistics (Y.J.).; Department of Genetics (Y.J.).
Bautch VL; Integrative Program for Biological & Genome Sciences (Z.L., D.L.R., V.L.B.).; McAllister Heart Institute (Z.L., D.L.R., V.L.B.).; Lineberger Comprehensive Cancer Center (D.L.R., Y.J., V.L.B.).; Curriculum in Cell Biology and Physiology (N.T.T., V.L.B.).; Department of Biology, University of North Carolina, Chapel Hill (V.L.B.).
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Oct; Vol. 41 (10), pp. 2575-2584. Date of Electronic Publication: 2021 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Expression Profiling*
Mechanotransduction, Cellular*
RNA-Seq*
Single-Cell Analysis*
Transcriptome*
Human Umbilical Vein Endothelial Cells/*metabolism
Animals ; Cells, Cultured ; Humans ; Mice ; Microscopy, Fluorescence ; Regional Blood Flow ; Stress, Mechanical
Czasopismo naukowe
Tytuł :
SCHNAPPs - Single Cell sHiNy APPlication(s).
Autorzy :
Jagla B; Institut Pasteur, Université de Paris, Cytometry and Biomarkers UTechS, F-75015 Paris, France; Institut Pasteur, Université de Paris, Bioinformatics and Biostatistics Hub, F-75015 Paris, France. Electronic address: .
Libri V; Institut Pasteur, Université de Paris, Cytometry and Biomarkers UTechS, F-75015 Paris, France.
Chica C; Institut Pasteur, Université de Paris, Bioinformatics and Biostatistics Hub, F-75015 Paris, France.
Rouilly V; Datactix, 40 rue Neuve, 33000, Bordeaux, France.
Mella S; Institut Pasteur, Université de Paris, Cytometry and Biomarkers UTechS, F-75015 Paris, France; Institut Pasteur, Université de Paris, Bioinformatics and Biostatistics Hub, F-75015 Paris, France.
Puceat M; Aix-Marseille University, INSERM U-1251, MMG, France.
Hasan M; Institut Pasteur, Université de Paris, Cytometry and Biomarkers UTechS, F-75015 Paris, France.
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Źródło :
Journal of immunological methods [J Immunol Methods] 2021 Dec; Vol. 499, pp. 113176. Date of Electronic Publication: 2021 Nov 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Sequence Analysis, RNA*
Single-Cell Analysis*
Software*
Leukocytes, Mononuclear/*cytology
Humans ; Leukocytes, Mononuclear/immunology
Czasopismo naukowe
Tytuł :
Combining bulk and single-cell RNA-sequencing data to reveal gene expression pattern of chondrocytes in the osteoarthritic knee.
Autorzy :
Li X; Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Key Laboratory of Bone and Cartilage Regeneration Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Liao Z; Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Key Laboratory of Bone and Cartilage Regeneration Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Deng Z; Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Key Laboratory of Bone and Cartilage Regeneration Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Chen N; Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Key Laboratory of Bone and Cartilage Regeneration Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhao L; Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Key Laboratory of Bone and Cartilage Regeneration Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Department of Orthopaedics, Shunde Hospital, Southern Medical University, Foshan, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 997-1007.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Sequence Analysis, RNA*
Single-Cell Analysis*
Chondrocytes/*metabolism
Knee Joint/*pathology
Osteoarthritis/*genetics
Osteoarthritis/*pathology
Gene Expression Profiling ; Gene Regulatory Networks ; Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Single-Cell Analysis of the In Vivo Dynamics of Host Circulating Immune Cells Highlights the Importance of Myeloid Cells in Avian Flaviviral Infection.
Autorzy :
Liang Y; State Key Laboratory of Veterinary Biotechnology, National Poultry Laboratory Animal Resource Center, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China; and.
Ma Y; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, People's Republic of China.
Zhang Y; State Key Laboratory of Veterinary Biotechnology, National Poultry Laboratory Animal Resource Center, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China; and.
Chen Z; State Key Laboratory of Veterinary Biotechnology, National Poultry Laboratory Animal Resource Center, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China; and.
Wang Z; State Key Laboratory of Veterinary Biotechnology, National Poultry Laboratory Animal Resource Center, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China; and.
Li X; State Key Laboratory of Veterinary Biotechnology, National Poultry Laboratory Animal Resource Center, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China; and.
Cui L; State Key Laboratory of Veterinary Biotechnology, National Poultry Laboratory Animal Resource Center, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China; and.
Xu L; State Key Laboratory of Veterinary Biotechnology, National Poultry Laboratory Animal Resource Center, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China; and.
Liu S; State Key Laboratory of Veterinary Biotechnology, National Poultry Laboratory Animal Resource Center, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China; and .
Li H; State Key Laboratory of Veterinary Biotechnology, National Poultry Laboratory Animal Resource Center, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China; and .
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Dec 01; Vol. 207 (11), pp. 2878-2891. Date of Electronic Publication: 2021 Oct 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Single-Cell Analysis*
Flavivirus Infections/*immunology
Myeloid Cells/*immunology
Animals ; Ducks/virology ; Female ; Male ; Myeloid Cells/pathology ; Myeloid Cells/virology
Czasopismo naukowe
Tytuł :
Automated annotation of rare-cell types from single-cell RNA-sequencing data through synthetic oversampling.
Autorzy :
Bej S; Department of Systems Biology and Bioinformatics, University of Rostock, 18057, Rostock, Germany.; Leibniz-Institute for Food Systems Biology, Technical University of Munich, 85354, Freising, Germany.
Galow AM; Institute of Genome Biology, Research Institute for Farm Animal Biology, 18196, Dummerstorf, Germany.
David R; Department of Cardiac Surgery, Rostock University Medical Centre, 18057, Rostock, Germany.; Department of Life, Light and Matter, University of Rostock, 18059, Rostock, Germany.
Wolfien M; Department of Systems Biology and Bioinformatics, University of Rostock, 18057, Rostock, Germany.
Wolkenhauer O; Department of Systems Biology and Bioinformatics, University of Rostock, 18057, Rostock, Germany. .; Leibniz-Institute for Food Systems Biology, Technical University of Munich, 85354, Freising, Germany. .; Stellenbosch Institute of Advanced Study, Stellenbosch University, Stellenbosch, 7602, South Africa. .
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2021 Nov 19; Vol. 22 (1), pp. 557. Date of Electronic Publication: 2021 Nov 19.
Typ publikacji :
Journal Article
MeSH Terms :
RNA*/genetics
Single-Cell Analysis*
Animals ; Cluster Analysis ; Machine Learning ; Mice ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
Asc-Seurat: analytical single-cell Seurat-based web application.
Autorzy :
Pereira WJ; School of Forest, Fisheries, and Geomatics Sciences, University of Florida, Gainesville, FL, 32611, USA. .
Almeida FM; Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, DF, 70910-900, Brazil.
Conde D; School of Forest, Fisheries, and Geomatics Sciences, University of Florida, Gainesville, FL, 32611, USA.
Balmant KM; School of Forest, Fisheries, and Geomatics Sciences, University of Florida, Gainesville, FL, 32611, USA.
Triozzi PM; School of Forest, Fisheries, and Geomatics Sciences, University of Florida, Gainesville, FL, 32611, USA.
Schmidt HW; School of Forest, Fisheries, and Geomatics Sciences, University of Florida, Gainesville, FL, 32611, USA.
Dervinis C; School of Forest, Fisheries, and Geomatics Sciences, University of Florida, Gainesville, FL, 32611, USA.
Pappas GJ Jr; Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, DF, 70910-900, Brazil.
Kirst M; School of Forest, Fisheries, and Geomatics Sciences, University of Florida, Gainesville, FL, 32611, USA.; Genetics Institute, University of Florida, Gainesville, FL, 32611, USA.
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2021 Nov 18; Vol. 22 (1), pp. 556. Date of Electronic Publication: 2021 Nov 18.
Typ publikacji :
Journal Article
MeSH Terms :
Single-Cell Analysis*
Software*
Cluster Analysis ; Gene Expression Profiling ; Leukocytes, Mononuclear ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
Ruthenium red: a highly efficient and versatile cell staining agent for single-cell analysis using inductively coupled plasma time-of-flight mass spectrometry.
Autorzy :
Qin W; Department of Analytical Chemistry, Helmholtz Centre for Environmental Research - UFZ, Permoserstrasse 15, 04318, Leipzig, Germany. .
Stärk HJ; Department of Analytical Chemistry, Helmholtz Centre for Environmental Research - UFZ, Permoserstrasse 15, 04318, Leipzig, Germany. .
Reemtsma T; Department of Analytical Chemistry, Helmholtz Centre for Environmental Research - UFZ, Permoserstrasse 15, 04318, Leipzig, Germany. .; Institute of Analytical Chemistry, University of Leipzig, Linnéstrasse 3, 04103, Leipzig, Germany.
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Źródło :
The Analyst [Analyst] 2021 Nov 08; Vol. 146 (22), pp. 6753-6759. Date of Electronic Publication: 2021 Nov 08.
Typ publikacji :
Journal Article
MeSH Terms :
Ruthenium Red*
Saccharomyces cerevisiae*
Single-Cell Analysis*
Humans ; Mass Spectrometry ; Staining and Labeling
Czasopismo naukowe
Tytuł :
scAdapt: virtual adversarial domain adaptation network for single cell RNA-seq data classification across platforms and species.
Autorzy :
Zhou X; School of Computer Science and Engineering at the Sun Yat-sen University, China.
Chai H; School of Computer Science and Engineering at the Sun Yat-sen University, China.
Zeng Y; School of Computer Science and Engineering at the Sun Yat-sen University, China.
Zhao H; Sun Yat-sen Memorial Hospital at the Sun Yat-sen University, China.
Yang Y; School of Computer Science and Engineering and the National Super Computer Center at Guangzhou, Sun Yat-sen University, China.
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Źródło :
Briefings in bioinformatics [Brief Bioinform] 2021 Nov 05; Vol. 22 (6).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Single-Cell Analysis*
COVID-19/*genetics
SARS-CoV-2/*genetics
Transcriptome/*genetics
COVID-19/virology ; Humans ; RNA-Seq ; SARS-CoV-2/isolation & purification ; Species Specificity ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
Systematic review on the current knowledge and use of single-cell RNA sequencing in head and neck cancer.
Autorzy :
Stampe H; Department of Otorhinolaryngology, Head and Neck Surgery, and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Jakobsen KK; Department of Otorhinolaryngology, Head and Neck Surgery, and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Bendtsen SK; Department of Otorhinolaryngology, Head and Neck Surgery, and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Grønhøj C; Department of Otorhinolaryngology, Head and Neck Surgery, and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
von Buchwald C; Department of Otorhinolaryngology, Head and Neck Surgery, and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
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Źródło :
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica [APMIS] 2021 Nov; Vol. 129 (11), pp. 619-625.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
Sequence Analysis, RNA*
Single-Cell Analysis*
Head and Neck Neoplasms/*genetics
Squamous Cell Carcinoma of Head and Neck/*genetics
Biomarkers, Tumor/genetics ; Gene Expression Profiling ; Genetic Heterogeneity ; Head and Neck Neoplasms/pathology ; Humans ; Squamous Cell Carcinoma of Head and Neck/pathology ; Tumor Microenvironment/genetics
Czasopismo naukowe
Tytuł :
Multi-omics integration in the age of million single-cell data.
Autorzy :
Miao Z; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.; Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Humphreys BD; Division of Nephrology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
McMahon AP; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Kim J; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA. .; Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. .
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Źródło :
Nature reviews. Nephrology [Nat Rev Nephrol] 2021 Nov; Vol. 17 (11), pp. 710-724. Date of Electronic Publication: 2021 Aug 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genomics*
Single-Cell Analysis*
Computational Biology ; Data Analysis ; Data Visualization ; Epigenomics ; Gene Expression Profiling ; Humans ; Proteomics
Czasopismo naukowe
Tytuł :
Single-cell analysis of regions of interest (SCARI) using a photosensitive tag.
Autorzy :
van der Leun AM; Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands.
Hoekstra ME; Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands.
Reinalda L; Department of Bio-Organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands.
Scheele CLGJ; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands.; VIB-KULeuven Center for Cancer Biology, Leuven, Belgium.
Toebes M; Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands.
van de Graaff MJ; Department of Bio-Organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands.; SeraNovo, Leiden, Netherlands.
Chen LYY; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands.
Li H; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.; Shenzhen Institute of Synthetic Biology, Shenzhen, China.
Bercovich A; Department of Computer Science and Applied Mathematics and Department of Biological Regulation, Weizmann Institute, Rehovot, Israel.
Lubling Y; Department of Computer Science and Applied Mathematics and Department of Biological Regulation, Weizmann Institute, Rehovot, Israel.; Cancer Research UK Cambridge Institute, Cambridge, UK.
David E; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Thommen DS; Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
Tanay A; Department of Computer Science and Applied Mathematics and Department of Biological Regulation, Weizmann Institute, Rehovot, Israel.
van Rheenen J; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands.
Amit I; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
van Kasteren SI; Department of Bio-Organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands. .
Schumacher TN; Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands. .; Department of Hematology, Leiden University Medical Center, Leiden, Netherlands. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Nov; Vol. 17 (11), pp. 1139-1147. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Single-Cell Analysis*
Benzofurans/*chemistry
CD8-Positive T-Lymphocytes/*cytology
Nitrophenols/*chemistry
Humans
Czasopismo naukowe
Tytuł :
Single-cell transcriptome analysis reveals defective decidua stromal niche attributes to recurrent spontaneous abortion.
Autorzy :
Du L; Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.; Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Guangzhou, China.; Guangdong Engineering and Technology Research Center of Maternal-Fetal Medicine, Guangzhou, China.
Deng W; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.; Key Laboratory of Reproductive Health Research, Fujian Province University, School of Medicine, Xiamen University, Xiamen, China.
Zeng S; Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xu P; Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Huang L; Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Liang Y; Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Wang Y; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.; Key Laboratory of Reproductive Health Research, Fujian Province University, School of Medicine, Xiamen University, Xiamen, China.
Xu H; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.; Key Laboratory of Reproductive Health Research, Fujian Province University, School of Medicine, Xiamen University, Xiamen, China.
Tang J; Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Bi S; Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhang L; Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Li Y; Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Ren L; Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Lin L; Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Deng W; Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Liu M; Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Chen J; Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.; Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Guangzhou, China.; Guangdong Engineering and Technology Research Center of Maternal-Fetal Medicine, Guangzhou, China.
Wang H; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.; Key Laboratory of Reproductive Health Research, Fujian Province University, School of Medicine, Xiamen University, Xiamen, China.
Chen D; Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.; Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Guangzhou, China.; Guangdong Engineering and Technology Research Center of Maternal-Fetal Medicine, Guangzhou, China.
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Źródło :
Cell proliferation [Cell Prolif] 2021 Nov; Vol. 54 (11), pp. e13125. Date of Electronic Publication: 2021 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Profiling*/methods
Single-Cell Analysis*/methods
Abortion, Habitual/*metabolism
Trophoblasts/*physiology
Abortion, Habitual/genetics ; Abortion, Habitual/pathology ; Adult ; Decidua/metabolism ; Decidua/pathology ; Female ; Humans ; Killer Cells, Natural/metabolism ; Pregnancy ; Trophoblasts/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Quantitative selection of single human sperm with high DNA integrity for intracytoplasmic sperm injection.
Autorzy :
Zhang Z; Department of Mechanical Engineering, University of Toronto, Toronto, Ontario, Canada.
Dai C; Department of Mechanical Engineering, University of Toronto, Toronto, Ontario, Canada.
Shan G; Department of Mechanical Engineering, University of Toronto, Toronto, Ontario, Canada.
Chen X; The Hospital for Sick Children, Toronto, Ontario, Canada.
Liu H; Department of Mechanical Engineering, University of Toronto, Toronto, Ontario, Canada.
Abdalla K; CReATe Fertility Centre, Toronto, Ontario, Canada.
Kuznyetsova I; CReATe Fertility Centre, Toronto, Ontario, Canada.
Moskovstev S; CReATe Fertility Centre, Toronto, Ontario, Canada.
Huang X; The Hospital for Sick Children, Toronto, Ontario, Canada.
Librach C; CReATe Fertility Centre, Toronto, Ontario, Canada.
Jarvi K; Mount Sinai Hospital, Toronto, Ontario, Canada.
Sun Y; Department of Mechanical Engineering, University of Toronto, Toronto, Ontario, Canada; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada; Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario, Canada; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada. Electronic address: .
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Źródło :
Fertility and sterility [Fertil Steril] 2021 Nov; Vol. 116 (5), pp. 1308-1318. Date of Electronic Publication: 2021 Jul 13.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Single-Cell Analysis*
Sperm Injections, Intracytoplasmic*/adverse effects
Sperm Motility*
DNA/*genetics
Infertility, Male/*therapy
Spermatozoa/*physiology
Algorithms ; Cell Shape ; Comet Assay ; DNA Fragmentation ; Fertility ; Humans ; Infertility, Male/diagnosis ; Infertility, Male/physiopathology ; Male ; Predictive Value of Tests ; Prospective Studies ; Reproducibility of Results ; Software ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Molecular and Cellular Dynamics of Aortic Aneurysms Revealed by Single-Cell Transcriptomics.
Autorzy :
Li Y; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX.
LeMaire SA; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX.
Shen YH; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Nov; Vol. 41 (11), pp. 2671-2680. Date of Electronic Publication: 2021 Oct 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Gene Expression Profiling*
Single-Cell Analysis*
Transcriptome*
Aorta/*metabolism
Aortic Aneurysm/*genetics
Animals ; Aorta/pathology ; Aortic Aneurysm/metabolism ; Aortic Aneurysm/pathology ; Dilatation, Pathologic ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Humans ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/pathology ; RNA-Seq
Czasopismo naukowe
Tytuł :
Single-cell nuclear architecture across cell types in the mouse brain.
Autorzy :
Takei Y; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Zheng S; Department of Genetics and Genomic Sciences and Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yun J; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Shah S; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Pierson N; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
White J; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Schindler S; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Tischbirek CH; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Yuan GC; Department of Genetics and Genomic Sciences and Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cai L; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Oct 29; Vol. 374 (6567), pp. 586-594. Date of Electronic Publication: 2021 Sep 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Single-Cell Analysis*
Cell Nucleus/*metabolism
Cell Nucleus/*ultrastructure
Cerebral Cortex/*cytology
Neuroglia/*ultrastructure
Neurons/*ultrastructure
Animals ; Cerebral Cortex/metabolism ; Chromatin/metabolism ; Chromatin/ultrastructure ; Chromosomes/metabolism ; Chromosomes/ultrastructure ; Endothelial Cells/metabolism ; Endothelial Cells/ultrastructure ; Epigenesis, Genetic ; Female ; Genome ; In Situ Hybridization, Fluorescence ; Mice ; Neuroglia/metabolism ; Neurons/metabolism ; RNA-Seq ; Transcription, Genetic ; Transcriptome ; X Chromosome/metabolism ; X Chromosome/ultrastructure
Czasopismo naukowe
Tytuł :
[A review on integration methods for single-cell data].
Autorzy :
Pan D; State Key Laboratory of Bioelectronics, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, P.R.China.
Li H; State Key Laboratory of Bioelectronics, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, P.R.China.
Liu H; State Key Laboratory of Bioelectronics, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, P.R.China.
Sun X; State Key Laboratory of Bioelectronics, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, P.R.China.
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Źródło :
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi [Sheng Wu Yi Xue Gong Cheng Xue Za Zhi] 2021 Oct 25; Vol. 38 (5), pp. 1010-1017.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Gene Expression Profiling*
Single-Cell Analysis*
Base Sequence ; Gene Expression Regulation ; Humans ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
Meta-analysis of COVID-19 single-cell studies confirms eight key immune responses.
Autorzy :
Garg M; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
Li X; School of Public Health (Shenzhen), Sun Yat-Sen University, Guangzhou, China.
Moreno P; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
Papatheodorou I; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
Shu Y; School of Public Health (Shenzhen), Sun Yat-Sen University, Guangzhou, China. .
Brazma A; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK. .
Miao Z; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK. .; Translational Research Institute of Brain and Brain-Like Intelligence and Department of Anesthesiology, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, 200081, China. .
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Źródło :
Scientific reports [Sci Rep] 2021 Oct 21; Vol. 11 (1), pp. 20833. Date of Electronic Publication: 2021 Oct 21.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA, Small Cytoplasmic*
Single-Cell Analysis*
Biomarkers/*metabolism
COVID-19/*immunology
COVID-19/*metabolism
Bronchoalveolar Lavage Fluid ; Computational Biology ; Databases, Factual ; Gene Expression Profiling/methods ; Genome, Human ; Genome, Viral ; Humans ; Immunity ; Leukocytes, Mononuclear/cytology ; RNA-Seq ; Reproducibility of Results ; SARS-CoV-2 ; Sequence Analysis, RNA/methods ; Signal Transduction ; Up-Regulation
Czasopismo naukowe
Tytuł :
Efficient and precise single-cell reference atlas mapping with Symphony.
Autorzy :
Kang JB; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Nathan A; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Weinand K; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Zhang F; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Millard N; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Rumker L; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Moody DB; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Korsunsky I; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA. .; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. .; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. .; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. .; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. .
Raychaudhuri S; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA. .; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. .; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. .; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. .; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. .; Versus Arthritis Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 07; Vol. 12 (1), pp. 5890. Date of Electronic Publication: 2021 Oct 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Genome*
Single-Cell Analysis*
Software*
Algorithms ; Computational Biology ; Humans
Czasopismo naukowe
Tytuł :
Comparative cellular analysis of motor cortex in human, marmoset and mouse.
Autorzy :
Bakken TE; Allen Institute for Brain Science, Seattle, WA, USA. .
Jorstad NL; Allen Institute for Brain Science, Seattle, WA, USA.
Hu Q; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Lake BB; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Tian W; The Salk Institute for Biological Studies, La Jolla, CA, USA.
Kalmbach BE; Allen Institute for Brain Science, Seattle, WA, USA.; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA.
Crow M; Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Hodge RD; Allen Institute for Brain Science, Seattle, WA, USA.
Krienen FM; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Sorensen SA; Allen Institute for Brain Science, Seattle, WA, USA.
Eggermont J; LKEB, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Yao Z; Allen Institute for Brain Science, Seattle, WA, USA.
Aevermann BD; J. Craig Venter Institute, La Jolla, CA, USA.
Aldridge AI; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Bartlett A; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Bertagnolli D; Allen Institute for Brain Science, Seattle, WA, USA.
Casper T; Allen Institute for Brain Science, Seattle, WA, USA.
Castanon RG; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Crichton K; Allen Institute for Brain Science, Seattle, WA, USA.
Daigle TL; Allen Institute for Brain Science, Seattle, WA, USA.
Dalley R; Allen Institute for Brain Science, Seattle, WA, USA.
Dee N; Allen Institute for Brain Science, Seattle, WA, USA.
Dembrow N; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA.; Epilepsy Center of Excellence, Department of Veterans Affairs Medical Center, Seattle, WA, USA.
Diep D; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Ding SL; Allen Institute for Brain Science, Seattle, WA, USA.
Dong W; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Fang R; Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, CA, USA.
Fischer S; Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Goldman M; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Goldy J; Allen Institute for Brain Science, Seattle, WA, USA.
Graybuck LT; Allen Institute for Brain Science, Seattle, WA, USA.
Herb BR; Institute for Genomes Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Hou X; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Kancherla J; Department of Computer Science, University of Maryland College Park, College Park, MD, USA.
Kroll M; Allen Institute for Brain Science, Seattle, WA, USA.
Lathia K; Allen Institute for Brain Science, Seattle, WA, USA.
van Lew B; LKEB, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Li YE; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.; Ludwig Institute for Cancer Research, La Jolla, CA, USA.
Liu CS; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.; Biomedical Sciences Program, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Liu H; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Lucero JD; The Salk Institute for Biological Studies, La Jolla, CA, USA.
Mahurkar A; Institute for Genomes Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
McMillen D; Allen Institute for Brain Science, Seattle, WA, USA.
Miller JA; Allen Institute for Brain Science, Seattle, WA, USA.
Moussa M; University of Connecticut, Storrs, CT, USA.
Nery JR; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Nicovich PR; Allen Institute for Brain Science, Seattle, WA, USA.
Niu SY; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.; Computer Science and Engineering Program, University of California, San Diego, La Jolla, CA, USA.
Orvis J; Institute for Genomes Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Osteen JK; The Salk Institute for Biological Studies, La Jolla, CA, USA.
Owen S; Allen Institute for Brain Science, Seattle, WA, USA.
Palmer CR; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.; Biomedical Sciences Program, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Pham T; Allen Institute for Brain Science, Seattle, WA, USA.
Plongthongkum N; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Poirion O; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Reed NM; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Rimorin C; Allen Institute for Brain Science, Seattle, WA, USA.
Rivkin A; The Salk Institute for Biological Studies, La Jolla, CA, USA.
Romanow WJ; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Sedeño-Cortés AE; Allen Institute for Brain Science, Seattle, WA, USA.
Siletti K; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Somasundaram S; Allen Institute for Brain Science, Seattle, WA, USA.
Sulc J; Allen Institute for Brain Science, Seattle, WA, USA.
Tieu M; Allen Institute for Brain Science, Seattle, WA, USA.
Torkelson A; Allen Institute for Brain Science, Seattle, WA, USA.
Tung H; Allen Institute for Brain Science, Seattle, WA, USA.
Wang X; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, USA.
Xie F; Department of Physics, University of California, San Diego, La Jolla, CA, USA.
Yanny AM; Allen Institute for Brain Science, Seattle, WA, USA.
Zhang R; J. Craig Venter Institute, La Jolla, CA, USA.
Ament SA; Institute for Genomes Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Behrens MM; The Salk Institute for Biological Studies, La Jolla, CA, USA.
Bravo HC; Department of Computer Science, University of Maryland College Park, College Park, MD, USA.
Chun J; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Dobin A; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Gillis J; Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Hertzano R; Departments of Otorhinolaryngology, Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Hof PR; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Höllt T; Computer Graphics and Visualization Group, Delt University of Technology, Delft, The Netherlands.
Horwitz GD; Department of Physiology and Biophysics, Washington National Primate Research Center, University of Washington, Seattle, WA, USA.
Keene CD; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Kharchenko PV; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Ko AL; Department of Neurological Surgery, University of Washington School of Medicine, Seattle, WA, USA.; Regional Epilepsy Center, Harborview Medical Center, Seattle, WA, USA.
Lelieveldt BP; LKEB, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.; Pattern Recognition and Bioinformatics group, Delft University of Technology, Delft, The Netherlands.
Luo C; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Mukamel EA; Department of Cognitive Science, University of California, San Diego, La Jolla, CA, USA.
Pinto-Duarte A; The Salk Institute for Biological Studies, La Jolla, CA, USA.
Preissl S; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Regev A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ren B; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.; Ludwig Institute for Cancer Research, La Jolla, CA, USA.
Scheuermann RH; J. Craig Venter Institute, La Jolla, CA, USA.; Department of Pathology, University of California, San Diego, CA, USA.; Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, USA.
Smith K; Allen Institute for Brain Science, Seattle, WA, USA.
Spain WJ; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA.; Epilepsy Center of Excellence, Department of Veterans Affairs Medical Center, Seattle, WA, USA.
White OR; Institute for Genomes Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Koch C; Allen Institute for Brain Science, Seattle, WA, USA.
Hawrylycz M; Allen Institute for Brain Science, Seattle, WA, USA.
Tasic B; Allen Institute for Brain Science, Seattle, WA, USA.
Macosko EZ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
McCarroll SA; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ting JT; Allen Institute for Brain Science, Seattle, WA, USA.; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA.
Zeng H; Allen Institute for Brain Science, Seattle, WA, USA.
Zhang K; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Feng G; McGovern Institute for Brain Research, MIT, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ecker JR; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.; Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Linnarsson S; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Lein ES; Allen Institute for Brain Science, Seattle, WA, USA. .
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Źródło :
Nature [Nature] 2021 Oct; Vol. 598 (7879), pp. 111-119. Date of Electronic Publication: 2021 Oct 06.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Single-Cell Analysis*
Motor Cortex/*cytology
Neurons/*classification
Animals ; Atlases as Topic ; Callithrix/genetics ; Epigenesis, Genetic ; Epigenomics ; Female ; GABAergic Neurons/cytology ; GABAergic Neurons/metabolism ; Gene Expression Profiling ; Glutamates/metabolism ; Humans ; In Situ Hybridization, Fluorescence ; Male ; Mice ; Middle Aged ; Motor Cortex/anatomy & histology ; Neurons/cytology ; Neurons/metabolism ; Organ Specificity ; Phylogeny ; Species Specificity ; Transcriptome
Czasopismo naukowe
Tytuł :
Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19.
Autorzy :
Xie X; State Key Laboratory of Experimental Hematology and National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.; Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China.
Cheng X; State Key Laboratory of Experimental Hematology and National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.; Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China.
Wang G; Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Zhang B; State Key Laboratory of Experimental Hematology and National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.; Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China.
Liu M; State Key Laboratory of Experimental Hematology and National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.; Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China.
Chen L; Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Cheng H; State Key Laboratory of Experimental Hematology and National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.; Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China.
Hao S; State Key Laboratory of Experimental Hematology and National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.; Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China.
Zhou J; Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. .
Zhu P; State Key Laboratory of Experimental Hematology and National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China. .; Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China. .
Cheng T; State Key Laboratory of Experimental Hematology and National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China. .; Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China. .
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Źródło :
Science China. Life sciences [Sci China Life Sci] 2021 Oct; Vol. 64 (10), pp. 1634-1644. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
Severity of Illness Index*
Single-Cell Analysis*
Transcriptome*
COVID-19/*physiopathology
Leukocytes, Mononuclear/*metabolism
CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; COVID-19/blood ; COVID-19/genetics ; COVID-19/virology ; Case-Control Studies ; Humans ; Killer Cells, Natural/immunology ; SARS-CoV-2/isolation & purification
Czasopismo naukowe

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