Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Wyszukujesz frazę ""Sirolimus"" wg kryterium: Temat


Tytuł:
Prevention of neointimal hyperplasia after coronary artery bypass graft via local delivery of sirolimus and rosuvastatin: network pharmacology and in vivo validation.
Autorzy:
Ryu JY; Division of Cardiovascular Surgery, Department of Thoracic and Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, 03722, South Korea.
Jang EH; Division of Cardiovascular Surgery, Department of Thoracic and Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, 03722, South Korea.
Lee J; School of Mechanical Engineering, Yonsei University, Seoul, 03722, South Korea.; Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Kim JH; Division of Cardiovascular Surgery, Department of Thoracic and Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, 03722, South Korea.
Youn YN; Division of Cardiovascular Surgery, Department of Thoracic and Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, 03722, South Korea. .
Pokaż więcej
Źródło:
Journal of translational medicine [J Transl Med] 2024 Feb 16; Vol. 22 (1), pp. 166. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
Sirolimus*/pharmacology
Sirolimus*/therapeutic use
Drugs, Chinese Herbal*
Animals ; Rabbits ; Rosuvastatin Calcium/pharmacology ; Rosuvastatin Calcium/therapeutic use ; Hyperplasia/drug therapy ; Matrix Metalloproteinase 9 ; Network Pharmacology ; Proto-Oncogene Proteins c-akt ; Neointima ; Coronary Artery Bypass/adverse effects
Czasopismo naukowe
Tytuł:
Biodegradable AZ91 magnesium alloy/sirolimus/poly D, L-lactic-co-glycolic acid-based substrate for cardiovascular device application.
Autorzy:
Mohanta M; Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Rourkela, Odisha, India.
Ramdhun Y; Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Rourkela, Odisha, India.
Thirugnanam A; Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Rourkela, Odisha, India.
Gupta R; Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Rourkela, Odisha, India.
Verma D; Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Rourkela, Odisha, India.
Deepak T; Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Rourkela, Odisha, India.
Babu AR; Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Rourkela, Odisha, India.
Pokaż więcej
Źródło:
Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2024 Jan; Vol. 112 (1), pp. e35350. Date of Electronic Publication: 2023 Nov 15.
Typ publikacji:
Journal Article
MeSH Terms:
Sirolimus*/pharmacology
Sirolimus*/chemistry
Magnesium*/pharmacology
Magnesium*/chemistry
Glycolates*
Glycols ; Alloys/chemistry ; Coated Materials, Biocompatible/pharmacology ; Coated Materials, Biocompatible/chemistry ; Lactic Acid/chemistry ; Alkalies ; Corrosion
Czasopismo naukowe
Tytuł:
Sirolimus-loaded exosomes as a promising vascular delivery system for the prevention of post-angioplasty restenosis.
Autorzy:
Mehryab F; Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, PO Box: 14155-6153, Tehran, Iran.
Rabbani S; Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Shekari F; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Nazari A; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Goshtasbi N; Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, PO Box: 14155-6153, Tehran, Iran.
Haeri A; Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, PO Box: 14155-6153, Tehran, Iran. a_.; Protein Technology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. a_.
Pokaż więcej
Źródło:
Drug delivery and translational research [Drug Deliv Transl Res] 2024 Jan; Vol. 14 (1), pp. 158-176. Date of Electronic Publication: 2023 Jul 30.
Typ publikacji:
Journal Article
MeSH Terms:
Sirolimus*/chemistry
Exosomes*
Rats ; Animals ; Angioplasty
Czasopismo naukowe
Tytuł:
Drug levels after sirolimus initiation and short-term outcomes in ambulatory heart transplantation recipients.
Autorzy:
Kancharla M; Peter Munk Cardiac Centre, Ajmera Transplant Program, University Health Network, Toronto, Ontario, Canada.; Royal College of Surgeons in Ireland, Dublin, Ireland.
Kugathasan L; Peter Munk Cardiac Centre, Ajmera Transplant Program, University Health Network, Toronto, Ontario, Canada.
McDonald M; Peter Munk Cardiac Centre, Ajmera Transplant Program, University Health Network, Toronto, Ontario, Canada.
Alba AC; Peter Munk Cardiac Centre, Ajmera Transplant Program, University Health Network, Toronto, Ontario, Canada.
Pokaż więcej
Źródło:
Clinical transplantation [Clin Transplant] 2024 Jan; Vol. 38 (1), pp. e15184. Date of Electronic Publication: 2023 Nov 07.
Typ publikacji:
Journal Article
MeSH Terms:
Sirolimus*/therapeutic use
Heart Transplantation*
Humans ; Middle Aged ; Immunosuppressive Agents/therapeutic use ; Tacrolimus ; Retrospective Studies ; Stroke Volume ; Ventricular Function, Left ; Graft Rejection/drug therapy ; Graft Rejection/etiology
Czasopismo naukowe
Tytuł:
Early therapy with sirolimus reduces size of a large solid renal mass but not seizure activity in an infant with tuberous sclerosis.
Autorzy:
Hani SB; Pediatric Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Artunduaga M; Department of Radiology, Pediatric Radiology Division, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ludwig K; Pediatric Hematology-Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Bissler JJ; Le Bonheur Children's Hospital, Memphis, TN, USA.; The University of Tennessee Health Science Center, Memphis, TN, USA.
Wolf MTF; Pediatric Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, USA. .
Pokaż więcej
Źródło:
Journal of nephrology [J Nephrol] 2024 Jan; Vol. 37 (1), pp. 203-205. Date of Electronic Publication: 2023 Sep 28.
Typ publikacji:
Journal Article
MeSH Terms:
Sirolimus*/therapeutic use
Tuberous Sclerosis*/complications
Tuberous Sclerosis*/drug therapy
Infant ; Humans ; Secondary Prevention ; Immunosuppressive Agents/adverse effects ; Kidney
Czasopismo naukowe
Tytuł:
Impact of the TOR pathway on plant growth via cell wall remodeling.
Autorzy:
Calderan-Rodrigues MJ; Max-Planck Institut für Molekulare Pflanzenphysiologie, 14476, Potsdam-Golm, Germany; Universidade de São Paulo, Escola Superior de Agricultura 'Luiz de Queiroz', 13418-900, Piracicaba, SP, Brazil. Electronic address: .
Caldana C; Max-Planck Institut für Molekulare Pflanzenphysiologie, 14476, Potsdam-Golm, Germany.
Pokaż więcej
Źródło:
Journal of plant physiology [J Plant Physiol] 2024 Mar; Vol. 294, pp. 154202. Date of Electronic Publication: 2024 Feb 22.
Typ publikacji:
Journal Article; Review
MeSH Terms:
TOR Serine-Threonine Kinases*/metabolism
Sirolimus*/metabolism
Plant Development/physiology ; Signal Transduction/physiology ; Plants/metabolism ; Cell Wall/metabolism
Czasopismo naukowe
Tytuł:
Rapamycin attenuates reconsolidation of a backwards-conditioned aversive stimuli in female mice.
Autorzy:
Trask J; Department of Psychology, Memorial University of Newfoundland, St. John's, NL, A1B 3X9, Canada.
MacCallum PE; Department of Psychology, Memorial University of Newfoundland, St. John's, NL, A1B 3X9, Canada.
Rideout H; Department of Psychology, Memorial University of Newfoundland, St. John's, NL, A1B 3X9, Canada.
Preisser EL; Department of Biological Sciences, University of Rhode Island, Kingston, RI, 02881, USA.
Blundell JJ; Department of Psychology, Memorial University of Newfoundland, St. John's, NL, A1B 3X9, Canada. .
Pokaż więcej
Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2024 Mar; Vol. 241 (3), pp. 601-612. Date of Electronic Publication: 2024 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
Sirolimus*/pharmacology
Affect*
Female ; Animals ; Mice ; Conditioning, Classical ; Conditioning, Operant ; TOR Serine-Threonine Kinases ; Mammals
Czasopismo naukowe
Tytuł:
Discrete Mechanistic Target of Rapamycin Signaling Pathways, Stem Cells, and Therapeutic Targets.
Autorzy:
Jhanwar-Uniyal M; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Zeller SL; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Spirollari E; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Das M; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Hanft SJ; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Gandhi CD; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Pokaż więcej
Źródło:
Cells [Cells] 2024 Feb 27; Vol. 13 (5). Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Sirolimus*/pharmacology
Glioblastoma*/metabolism
Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Signal Transduction ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Stem Cells/metabolism ; Intercellular Signaling Peptides and Proteins/therapeutic use
Czasopismo naukowe
Tytuł:
Focusing on the role of protein kinase mTOR in endometrial physiology and pathology: insights for therapeutic interventions.
Autorzy:
Wang B; The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Gao M; Reproductive Medicine Center, The First Hospital of Lanzhou University, Lanzhou, China.; Key Laboratory for Reproductive Medicine and Embryo of Gansu, Lanzhou, China.
Yao Y; The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Li H; The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Zhang X; Reproductive Medicine Center, The First Hospital of Lanzhou University, Lanzhou, China. .; Key Laboratory for Reproductive Medicine and Embryo of Gansu, Lanzhou, China. .
Pokaż więcej
Źródło:
Molecular biology reports [Mol Biol Rep] 2024 Feb 24; Vol. 51 (1), pp. 359. Date of Electronic Publication: 2024 Feb 24.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Sirolimus*/therapeutic use
Endometriosis*/metabolism
Animals ; Female ; Humans ; Endometrium/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Signal Transduction ; Protein Serine-Threonine Kinases/metabolism ; Mammals/metabolism
Czasopismo naukowe
Tytuł:
Add-on sirolimus for the treatment of mild or moderate systemic lupus erythematosus via T lymphocyte subsets balance.
Autorzy:
Ding M; Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Jin L; Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Zhao J; Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Yang L; Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Cui S; Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Wang X; Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
He J; Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Chang F; Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Shi M; Department of Clinical Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.; Hebei Key Laboratory of Laboratory Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Ma J; Department of Anatomy, Hebei Medical University, Shijiazhuang, Hebei, China.; Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei, China.
Song S; Department of Clinical Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.; Hebei Key Laboratory of Laboratory Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Jin H; Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China .
Liu A; Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China .; Hebei Key Laboratory of Laboratory Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.; Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei, China.
Pokaż więcej
Źródło:
Lupus science & medicine [Lupus Sci Med] 2024 Feb 13; Vol. 11 (1). Date of Electronic Publication: 2024 Feb 13.
Typ publikacji:
Journal Article
MeSH Terms:
Sirolimus*/adverse effects
Lupus Erythematosus, Systemic*
Humans ; Retrospective Studies ; T-Lymphocyte Subsets/metabolism ; Cytokines
Czasopismo naukowe
Tytuł:
Targeting ageing with rapamycin and its derivatives in humans: a systematic review.
Autorzy:
Lee DJW; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Hodzic Kuerec A; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Centre for Healthy Longevity, @AgeSingapore National University Health System, Singapore.
Maier AB; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Centre for Healthy Longevity, @AgeSingapore National University Health System, Singapore; Department of Human Movement Sciences, @AgeAmsterdam, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands. Electronic address: .
Pokaż więcej
Źródło:
The lancet. Healthy longevity [Lancet Healthy Longev] 2024 Feb; Vol. 5 (2), pp. e152-e162.
Typ publikacji:
Systematic Review; Journal Article; Review
MeSH Terms:
Aging*
Sirolimus*/pharmacology
Humans
Czasopismo naukowe
Tytuł:
The Role of mTOR in Doxorubicin-Altered Cardiac Metabolism: A Promising Therapeutic Target of Natural Compounds.
Autorzy:
Yarmohammadi F; Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Hesari M; Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Shackebaei D; Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. .
Pokaż więcej
Źródło:
Cardiovascular toxicology [Cardiovasc Toxicol] 2024 Feb; Vol. 24 (2), pp. 146-157. Date of Electronic Publication: 2023 Dec 18.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cardiotoxicity*/metabolism
Sirolimus*
Humans ; Autophagy ; Doxorubicin/toxicity ; TOR Serine-Threonine Kinases/metabolism ; Oxidative Stress ; Myocytes, Cardiac ; Apoptosis
Czasopismo naukowe
Tytuł:
CD133-Dependent Activation of Phosphoinositide 3-Kinase /AKT/Mammalian Target of Rapamycin Signaling in Melanoma Progression and Drug Resistance.
Autorzy:
Kharouf N; Institut National de la Santé et de la Recherche Médicale, University of Strasbourg, 67000 Strasbourg, France.; Department of Operative Dentistry and Endodontics, Dental Faculty, University of Strasbourg, 67000 Strasbourg, France.
Flanagan TW; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, LA 70112, USA.
Alamodi AA; College of Health Sciences, Jackson State University, Jackson, MS 39213, USA.
Al Hmada Y; Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Hassan SY; Department of Pharmacy, Faculty of Science, Heinrich-Heine University Duesseldorf, 40225 Dusseldorf, Germany.
Shalaby H; Department of Urology, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Santourlidis S; Epigenetics Core Laboratory, Institute of Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Duesseldorf, 40225 Duesseldorf, Germany.
Hassan SL; Department of Chemistry, Faculty of Science, Heinrich-Heine University Duesseldorf, 40225 Dusseldorf, Germany.
Haikel Y; Institut National de la Santé et de la Recherche Médicale, University of Strasbourg, 67000 Strasbourg, France.; Department of Operative Dentistry and Endodontics, Dental Faculty, University of Strasbourg, 67000 Strasbourg, France.; Pôle de Médecine et Chirurgie Bucco-Dentaire, Hôpital Civil, Hôpitaux Universitaire de Strasbourg, 67000 Strasbourg, France.
Megahed M; Clinic of Dermatology, University Hospital of Aachen, 52074 Aachen, Germany.
Brodell RT; Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Hassan M; Institut National de la Santé et de la Recherche Médicale, University of Strasbourg, 67000 Strasbourg, France.; Department of Operative Dentistry and Endodontics, Dental Faculty, University of Strasbourg, 67000 Strasbourg, France.; Research Laboratory of Surgery-Oncology, Department of Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Pokaż więcej
Źródło:
Cells [Cells] 2024 Jan 26; Vol. 13 (3). Date of Electronic Publication: 2024 Jan 26.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Sirolimus*/pharmacology
Melanoma*/pathology
Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Drug Resistance, Neoplasm
Czasopismo naukowe
Tytuł:
Facilitating the development of molecular glues: Opportunities from serendipity and rational design.
Autorzy:
Jiang W; Laboratory of Human Diseases and Immunotherapies, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Jiang Y; Laboratory of Human Diseases and Immunotherapies, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China; Cardiovascular Surgery Research Laboratory, West China Hospital, Sichuan University, Chengdu, 610041, China.
Luo Y; Laboratory of Human Diseases and Immunotherapies, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: luo_.
Qiao W; Lung Cancer Center, Laboratory of Lung Cancer, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: .
Yang T; Laboratory of Human Diseases and Immunotherapies, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: .
Pokaż więcej
Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2024 Jan 05; Vol. 263, pp. 115950. Date of Electronic Publication: 2023 Nov 16.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Drug Discovery*
Sirolimus*
Czasopismo naukowe
Tytuł:
Long and Short-Term Effect of mTOR Regulation on Cerebral Organoid Growth and Differentiations.
Autorzy:
Park SB; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, Republic of Korea.
Lim B; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, Republic of Korea.
Kim KY; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, Republic of Korea. .
Koh B; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, Republic of Korea. .
Pokaż więcej
Źródło:
Tissue engineering and regenerative medicine [Tissue Eng Regen Med] 2024 Jan; Vol. 21 (1), pp. 159-169. Date of Electronic Publication: 2023 Dec 28.
Typ publikacji:
Journal Article
MeSH Terms:
Everolimus*
Sirolimus*/pharmacology
Organoids/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Brain/growth & development
Czasopismo naukowe
Tytuł:
Head and neck cancer stem cell maintenance relies on mTOR signaling, specifically involving the mechanistic target of rapamycin complexes 1 and 2 (mTORC1 and mTORC2).
Autorzy:
Almeida LO; Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA; Department of Basic and Oral Biology, University of Sao Paulo School of Dentistry, Ribeirao Preto, São Paulo, Brazil.
Silva LC; Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
Emerick C; Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
Amorim Dos Santos J; Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Castilho RM; Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Squarize CH; Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA. Electronic address: .
Pokaż więcej
Źródło:
Archives of oral biology [Arch Oral Biol] 2024 Jan; Vol. 157, pp. 105840. Date of Electronic Publication: 2023 Nov 01.
Typ publikacji:
Journal Article
MeSH Terms:
Sirolimus*/pharmacology
Head and Neck Neoplasms*
Humans ; Mechanistic Target of Rapamycin Complex 2/genetics ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Squamous Cell Carcinoma of Head and Neck ; TOR Serine-Threonine Kinases ; Stem Cells/metabolism
Czasopismo naukowe
Tytuł:
The exception to the rule? TORC1 triggers growth under low nutrient environments.
Autorzy:
Lopez LE; Fundación Instituto Leloir and IIBBA-CONICET. Av. Patricias Argentinas 435, Buenos Aires C1405BWE, Argentina.
Pacheco JM; Fundación Instituto Leloir and IIBBA-CONICET. Av. Patricias Argentinas 435, Buenos Aires C1405BWE, Argentina; Plant Molecular and Cellular Biology Laboratory and Integrative Biology Laboratory, Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA.
Estevez JM; Fundación Instituto Leloir and IIBBA-CONICET. Av. Patricias Argentinas 435, Buenos Aires C1405BWE, Argentina; ANID - Millennium Science Initiative Program - Millennium Nucleus for the Development of Super Adaptable Plants (MN-SAP), Santiago 8370146, Chile; Millennium Science Initiative Program - Millennium Institute for Integrative Biology (iBio), Santiago 8331150, Chile; Centro de Biotecnología Vegetal (CBV), Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago 8370146, Chile. Electronic address: .
Pokaż więcej
Źródło:
Trends in plant science [Trends Plant Sci] 2024 Jan; Vol. 29 (1), pp. 13-15. Date of Electronic Publication: 2023 Oct 16.
Typ publikacji:
Journal Article
MeSH Terms:
Sirolimus*
Nutrients*
Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism
Czasopismo naukowe
Tytuł:
Rapamycin functionalized carbon Dots: Target-oriented synthesis and suppression of vascular cell senescence.
Autorzy:
Dong J; Institute for Advanced Ceramics, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, PR China.
Wang Q; Department of Ophthalmology, The Second Affiliated Hospital of Harbin Medical University, Harbin, PR China.
Gu T; Institute for Advanced Ceramics, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, PR China.
Liu G; Institute for Advanced Ceramics, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, PR China.
Petrov YV; Laboratory of Dynamics and Extreme Characteristics of Promising Nanostructured Materials, Saint Petersburg State University, St. Petersburg, 199034, Russia.
Baulin VE; Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, 142432, Russia; Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow, 119071, Russia.
Yu Tsivadze A; Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow, 119071, Russia.
Jia D; Institute for Advanced Ceramics, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, PR China.
Zhou Y; Institute for Advanced Ceramics, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, PR China.
Yuan H; Department of Ophthalmology, The Second Affiliated Hospital of Harbin Medical University, Harbin, PR China. Electronic address: .
Li B; Institute for Advanced Ceramics, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, PR China; Laboratory of Dynamics and Extreme Characteristics of Promising Nanostructured Materials, Saint Petersburg State University, St. Petersburg, 199034, Russia. Electronic address: .
Pokaż więcej
Źródło:
Journal of colloid and interface science [J Colloid Interface Sci] 2024 Apr 15; Vol. 660, pp. 534-544. Date of Electronic Publication: 2024 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
Signal Transduction*/physiology
Sirolimus*/pharmacology
Humans ; Reactive Oxygen Species/metabolism ; TOR Serine-Threonine Kinases/metabolism ; TOR Serine-Threonine Kinases/pharmacology ; Human Umbilical Vein Endothelial Cells/metabolism ; Cellular Senescence ; Carbon/pharmacology
Czasopismo naukowe
Tytuł:
Rapamycin promotes hematoma resorption and enhances endothelial cell function by suppressing the mTOR/STAT3 signaling in chronic subdural hematoma.
Autorzy:
Shen J; Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, PR China. Electronic address: .
Zhang Y; Department of Neurosurgery, Xijing Hospital, Xi'an, 710000, Shaanxi, PR China.
Wu X; Department of Neurosurgery, The People's Hospital of Sixian County, Suzhou, 234399, Anhui, PR China.
Pokaż więcej
Źródło:
Experimental cell research [Exp Cell Res] 2023 Dec 15; Vol. 433 (2), pp. 113829. Date of Electronic Publication: 2023 Oct 24.
Typ publikacji:
Journal Article
MeSH Terms:
Hematoma, Subdural, Chronic*/drug therapy
Hematoma, Subdural, Chronic*/metabolism
Sirolimus*/pharmacology
Sirolimus*/therapeutic use
Aged ; Animals ; Humans ; Rats ; Atorvastatin/pharmacology ; Atorvastatin/therapeutic use ; Endothelial Cells/metabolism ; Signal Transduction ; STAT3 Transcription Factor/drug effects ; STAT3 Transcription Factor/metabolism ; TOR Serine-Threonine Kinases/drug effects ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł:
High rapamycin-loaded hollow mesoporous Prussian blue nanozyme targets lesion area of spinal cord injury to recover locomotor function.
Autorzy:
Shen K; Department of Orthopedics, Department of Neurology and Stroke Center, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, 510632, China.
Li X; Department of Orthopedics, Department of Neurology and Stroke Center, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, 510632, China.
Huang G; Department of Orthopedics, Department of Neurology and Stroke Center, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, 510632, China; Department of Chemistry, Jinan University, Guangzhou, 510632, China.
Yuan Z; Department of Chemistry, Jinan University, Guangzhou, 510632, China.
Xie B; Department of Chemistry, Jinan University, Guangzhou, 510632, China.
Chen T; Department of Orthopedics, Department of Neurology and Stroke Center, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, 510632, China. Electronic address: .
He L; Department of Orthopedics, Department of Neurology and Stroke Center, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, 510632, China. Electronic address: .
Pokaż więcej
Źródło:
Biomaterials [Biomaterials] 2023 Dec; Vol. 303, pp. 122358. Date of Electronic Publication: 2023 Oct 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Sirolimus*/pharmacology
Sirolimus*/therapeutic use
Spinal Cord Injuries*/drug therapy
Spinal Cord Injuries*/pathology
Rats ; Mice ; Animals ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Antioxidants/metabolism ; Oxygen/metabolism ; Spinal Cord/pathology
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies