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Wyszukujesz frazę ""Sirtuin 2"" wg kryterium: Temat


Tytuł :
SIRT2 modulates VEGFD-associated lymphangiogenesis by deacetylating EPAS1 in human head and neck cancer.
Autorzy :
Hu A; Department of Otolaryngology-Head and Neck Surgery, Gongli Hospital, Second Military Medical University, Shanghai, China.
Yang LY; Department of Otolaryngology-Head and Neck Surgery, Gongli Hospital, Second Military Medical University, Shanghai, China.
Liang J; Department of Otolaryngology-Head and Neck Surgery, Gongli Hospital, Second Military Medical University, Shanghai, China.
Lu D; Department of Otolaryngology-Head and Neck Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang JL; Department of Otolaryngology, Jinqiao Community Health Service Center, Shanghai, China.
Cao FF; Department of Sino-French Cooperative Central Lab, Gongli Hospital, Second Military Medical University, Shanghai, China.
Fu JY; Department of Otolaryngology-Head and Neck Surgery, Gongli Hospital, Second Military Medical University, Shanghai, China.
Dai WJ; Department of Otolaryngology-Head and Neck Surgery, Gongli Hospital, Second Military Medical University, Shanghai, China.
Zhang JF; Department of Otolaryngology-Head and Neck Surgery, Gongli Hospital, Second Military Medical University, Shanghai, China.
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Źródło :
Molecular carcinogenesis [Mol Carcinog] 2020 Nov; Vol. 59 (11), pp. 1280-1291. Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Lymphangiogenesis*
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Biomarkers, Tumor/*metabolism
Head and Neck Neoplasms/*pathology
Sirtuin 2/*metabolism
Vascular Endothelial Growth Factor D/*metabolism
Acetylation ; Animals ; Apoptosis ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Biomarkers, Tumor/genetics ; Cell Proliferation ; Female ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/metabolism ; Humans ; Lymphatic Metastasis ; Mice ; Mice, Nude ; Neoplasm Invasiveness ; Sirtuin 2/genetics ; Tumor Cells, Cultured ; Vascular Endothelial Growth Factor D/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Modulation of Human Arylamine N -Acetyltransferase 1 Activity by Lysine Acetylation: Role of p300/CREB-Binding Protein and Sirtuins 1 and 2.
Autorzy :
Butcher NJ; School of Biomedical Sciences, University of Queensland, St Lucia, Queensland, Australia .
Burow R; School of Biomedical Sciences, University of Queensland, St Lucia, Queensland, Australia.
Minchin RF; School of Biomedical Sciences, University of Queensland, St Lucia, Queensland, Australia.
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2020 Aug; Vol. 98 (2), pp. 88-95. Date of Electronic Publication: 2020 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arylamine N-Acetyltransferase/*chemistry
Arylamine N-Acetyltransferase/*metabolism
CREB-Binding Protein/*genetics
E1A-Associated p300 Protein/*genetics
Isoenzymes/*chemistry
Isoenzymes/*metabolism
Sirtuin 1/*genetics
Sirtuin 2/*genetics
Acetyl Coenzyme A/metabolism ; Acetylation/drug effects ; Arylamine N-Acetyltransferase/genetics ; Benzoates/pharmacology ; CREB-Binding Protein/metabolism ; Crystallography, X-Ray ; E1A-Associated p300 Protein/metabolism ; HeLa Cells ; Humans ; Hydroxamic Acids/pharmacology ; Isoenzymes/genetics ; Lysine/chemistry ; Lysine/genetics ; Models, Molecular ; Mutagenesis, Site-Directed ; Niacinamide/pharmacology ; Protein Conformation ; Pyrazoles/pharmacology ; Sirtuin 1/metabolism ; Sirtuin 2/metabolism ; Transfection
Czasopismo naukowe
Tytuł :
Depletion of microRNA-451 in response to allergen exposure accentuates asthmatic inflammation by regulating Sirtuin2.
Autorzy :
Chung S; Pulmonary, Critical Care, and Sleep Medicine, the Ohio State University, Davis Heart and Lung Research Institute, Columbus, Ohio.
Lee YG; Pulmonary, Critical Care, and Sleep Medicine, the Ohio State University, Davis Heart and Lung Research Institute, Columbus, Ohio.
Karpurapu M; Pulmonary, Critical Care, and Sleep Medicine, the Ohio State University, Davis Heart and Lung Research Institute, Columbus, Ohio.
Englert JA; Pulmonary, Critical Care, and Sleep Medicine, the Ohio State University, Davis Heart and Lung Research Institute, Columbus, Ohio.
Ballinger MN; Pulmonary, Critical Care, and Sleep Medicine, the Ohio State University, Davis Heart and Lung Research Institute, Columbus, Ohio.
Davis IC; College of Veterinary Medicine, the Ohio State University, Columbus, Ohio.
Park GY; Department of Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, University of Illinois at Chicago, Chicago, Illinois.
Christman JW; Pulmonary, Critical Care, and Sleep Medicine, the Ohio State University, Davis Heart and Lung Research Institute, Columbus, Ohio.
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Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2020 May 01; Vol. 318 (5), pp. L921-L930. Date of Electronic Publication: 2020 Mar 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Asthma/*genetics
Macrophages, Alveolar/*immunology
MicroRNAs/*genetics
Pneumonia/*genetics
Sirtuin 2/*genetics
Allergens/administration & dosage ; Animals ; Anti-Inflammatory Agents/pharmacology ; Antigens, Plant/administration & dosage ; Aspergillus/chemistry ; Aspergillus/immunology ; Asthma/chemically induced ; Asthma/pathology ; Asthma/therapy ; Chemokine CCL17/genetics ; Chemokine CCL17/immunology ; Disease Models, Animal ; Fungi/chemistry ; Fungi/immunology ; Furans/pharmacology ; Gene Expression Regulation ; Lung/drug effects ; Lung/immunology ; Lung/pathology ; Macrophage Activation/drug effects ; Macrophages, Alveolar/drug effects ; Macrophages, Alveolar/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; MicroRNAs/immunology ; Plant Extracts/administration & dosage ; Pneumonia/chemically induced ; Pneumonia/pathology ; Pneumonia/therapy ; Pyroglyphidae/chemistry ; Pyroglyphidae/immunology ; Quinolines/pharmacology ; Signal Transduction ; Sirtuin 2/antagonists & inhibitors ; Sirtuin 2/immunology
Czasopismo naukowe
Tytuł :
An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone Lysine Methyltransferases.
Autorzy :
Piracha ZZ; Department of Microbiology, Ajou University School of Medicine, Suwon, South Korea.; Department of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea.
Saeed U; Department of Microbiology, Ajou University School of Medicine, Suwon, South Korea.; Department of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea.
Kim J; Department of Microbiology, Ajou University School of Medicine, Suwon, South Korea.; Department of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea.
Kwon H; Department of Microbiology, Ajou University School of Medicine, Suwon, South Korea.; Department of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea.
Chwae YJ; Department of Microbiology, Ajou University School of Medicine, Suwon, South Korea.; Department of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea.
Lee HW; Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Lim JH; Department of General Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Park S; Department of Microbiology, Ajou University School of Medicine, Suwon, South Korea.; Department of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea.
Shin HJ; Department of Microbiology, Ajou University School of Medicine, Suwon, South Korea.; Department of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea.
Kim K; Department of Microbiology, Ajou University School of Medicine, Suwon, South Korea .; Department of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea.
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Źródło :
Journal of virology [J Virol] 2020 Jul 30; Vol. 94 (16). Date of Electronic Publication: 2020 Jul 30 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA, Circular/*genetics
Hepatitis B virus/*physiology
Histone-Lysine N-Methyltransferase/*genetics
Sirtuin 2/*genetics
Virus Replication/*genetics
Alternative Splicing ; Cell Line, Tumor ; DNA, Circular/metabolism ; DNA, Viral/genetics ; DNA, Viral/metabolism ; Epigenesis, Genetic ; Epigenetic Repression ; Hepatitis B/virology ; Hepatitis B virus/genetics ; Hepatitis B virus/growth & development ; Histone-Lysine N-Methyltransferase/metabolism ; Histones/metabolism ; Humans ; Protein Isoforms ; Sirtuin 2/metabolism ; Transcription, Genetic ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
Anesthetic preconditioning increases sirtuin 2 gene expression in a renal ischemia reperfusion injury model.
Autorzy :
Echavarría R; Western Biomedical Research Center, National Council of Science and Technology (CONACyT), Mexical Institute of Social Security (IMSS), Guadalajara, Mexico.
Garcia D; Western Biomedical Research Center, National Council of Science and Technology (CONACyT), Mexical Institute of Social Security (IMSS), Guadalajara, Mexico.
Figueroa F; High Specialty Medical Unit, Western Biomedical Research Center, Mexical Institute of Social Security (IMSS), Guadalajara, Mexico.
Franco-Acevedo A; Western Biomedical Research Center, National Council of Science and Technology (CONACyT), Mexical Institute of Social Security (IMSS), Guadalajara, Mexico.; University of Guadalajara, Guadalajara, Mexico.
Palomino J; Western Biomedical Research Center, National Council of Science and Technology (CONACyT), Mexical Institute of Social Security (IMSS), Guadalajara, Mexico.; Durango-Santander University, Hermosillo, Mexico.
Portilla-Debuen E; Western Biomedical Research Center, National Council of Science and Technology (CONACyT), Mexical Institute of Social Security (IMSS), Guadalajara, Mexico.
Goldaraz-Monraz MP; High Specialty Medical Unit, Western Biomedical Research Center, Mexical Institute of Social Security (IMSS), Guadalajara, Mexico.
Moreno-Carranza B; Institute of Neurobiology, National Autonomous University of Mexico (UNAM), Querétaro, Mexico.; School of Medicine, Anáhuac Querétaro University, El Marqués, Mexico.
Melo Z; Western Biomedical Research Center, National Council of Science and Technology (CONACyT), Mexical Institute of Social Security (IMSS), Guadalajara, Mexico - .
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Źródło :
Minerva urologica e nefrologica = The Italian journal of urology and nephrology [Minerva Urol Nefrol] 2020 Apr; Vol. 72 (2), pp. 243-249. Date of Electronic Publication: 2019 Nov 11.
Typ publikacji :
Journal Article
MeSH Terms :
Anesthetics/*pharmacology
Kidney Diseases/*genetics
Reperfusion Injury/*genetics
Sirtuin 2/*biosynthesis
Sirtuin 2/*genetics
Acute Kidney Injury/blood ; Acute Kidney Injury/prevention & control ; Animals ; Cell Adhesion Molecules/blood ; Creatinine/blood ; Dexmedetomidine/therapeutic use ; Gene Expression/drug effects ; Kidney Diseases/prevention & control ; Male ; Rats ; Rats, Wistar ; Reperfusion Injury/prevention & control ; Sirtuin 2/drug effects ; Sirtuins/biosynthesis
Czasopismo naukowe
Tytuł :
SIRT2 Affects Primary Cilia Formation by Regulating mTOR Signaling in Retinal Pigmented Epithelial Cells.
Autorzy :
Lim J; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Son J; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Ryu J; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Kim JE; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea.; Department of Pharmacology, School of Medicine, Kyung Hee University, Seoul 02447, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Mar 24; Vol. 21 (6). Date of Electronic Publication: 2020 Mar 24.
Typ publikacji :
Journal Article
MeSH Terms :
Cilia/*metabolism
Retinal Pigment Epithelium/*metabolism
Sirtuin 2/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Benzamides/pharmacology ; Cell Cycle ; Cell Line ; Enzyme Inhibitors/pharmacology ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Humans ; Retinal Pigment Epithelium/cytology ; Signal Transduction ; Sirtuin 2/antagonists & inhibitors ; Sirtuin 2/genetics ; Sulfonamides/pharmacology
Czasopismo naukowe
Tytuł :
QSAR studies on the human sirtuin 2 inhibition by non-covalent 7,5,2-anilinobenzamide derivatives.
Autorzy :
Ferreira GM; Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, SP, Brazil.
Magalhães JG; Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, SP, Brazil.
Maltarollo VG; Department of Pharmaceutical Products, Faculty of Pharmacy, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Kronenberger T; Department of Internal Medicine VIII, University Hospital Tübingen, Tübingen, Germany.
Ganesan A; School of Pharmacy, University of East Anglia, Norwich, UK.
Emery FDS; Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Trossini GHG; Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, SP, Brazil.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2020 Feb; Vol. 38 (2), pp. 354-363. Date of Electronic Publication: 2019 Feb 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Quantitative Structure-Activity Relationship*
Benzamides/*pharmacology
Sirtuin 2/*antagonists & inhibitors
Sirtuin 2/*chemistry
Acetylation/drug effects ; Catalytic Domain ; Epigenesis, Genetic/drug effects ; Humans ; Molecular Docking Simulation ; Reproducibility of Results ; Sirtuin 2/metabolism
Czasopismo naukowe
Tytuł :
Sirt2-associated transcriptome modifications in cisplatin-induced neuronal injury.
Autorzy :
Zhao X; Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.; Institute for Systems Genetics, NYU Langone Health, New York, NY, 10016, USA.
Du W; Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Zhang M; Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Atiq ZO; Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Xia F; Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA. .
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Źródło :
BMC genomics [BMC Genomics] 2020 Mar 02; Vol. 21 (1), pp. 192. Date of Electronic Publication: 2020 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Cisplatin/*adverse effects
Gene Expression Profiling/*methods
Gene Regulatory Networks/*drug effects
Neurons/*cytology
Sirtuin 2/*genetics
Animals ; Cell Culture Techniques ; Cell Differentiation/drug effects ; Gene Expression Regulation/drug effects ; Gene Knockout Techniques ; Neurons/drug effects ; Neurons/metabolism ; PC12 Cells ; Rats ; Sequence Analysis, RNA ; Sirtuin 2/metabolism
Czasopismo naukowe
Tytuł :
SIRT2 expression exhibits potential to serve as a biomarker for disease surveillance and prognosis in the management of cervical cancer patients.
Autorzy :
Yang LP; Department of Gynaecology and Obstetrics.
Feng HQ; Department of Gynaecology and Obstetrics.
Ma JC; Department of Gynaecology and Obstetrics.
Wu H; Department of Gynaecology and Obstetrics.
Liu CR; Department of Gynaecology and Obstetrics.
Hou JD; Department of Anesthesiology, HanDan Central Hospital, Handan 056008, China.
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Mar; Vol. 99 (11), pp. e18668.
Typ publikacji :
Journal Article
MeSH Terms :
Sirtuin 2/*metabolism
Uterine Cervical Neoplasms/*diagnosis
Adult ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/metabolism ; Cervix Uteri/metabolism ; Disease-Free Survival ; Female ; Humans ; Middle Aged ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Sirtuin 2/analysis ; Survival Analysis ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/mortality
Czasopismo naukowe
Tytuł :
Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors.
Autorzy :
Khalil NA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Kasr El-Aini Street, 11562, Egypt. Electronic address: .
Ahmed EM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Kasr El-Aini Street, 11562, Egypt.
Zaher AF; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Kasr El-Aini Street, 11562, Egypt.
El-Zoghbi MS; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Menoufia University, Menoufia, Gamal Abd El-Nasir Street, Egypt.
Sobh EA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Menoufia University, Menoufia, Gamal Abd El-Nasir Street, Egypt. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 Feb 01; Vol. 187, pp. 111926. Date of Electronic Publication: 2019 Nov 30.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Histone Deacetylase Inhibitors/*pharmacology
Pyrimidines/*pharmacology
Sirtuin 2/*antagonists & inhibitors
Thiophenes/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Humans ; Molecular Structure ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Sirtuin 2/metabolism ; Structure-Activity Relationship ; Thiophenes/chemical synthesis ; Thiophenes/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases.
Autorzy :
Zhang Y; Menzies Health Institute Queensland, Griffith University, Queensland, 4222, Australia; School of Pharmacy and Pharmacology, Griffith University, Gold Coast Campus, Queensland, 4222, Australia; Quality Use of Medicines Network, Queensland, 4222, Australia. Electronic address: .
Anoopkumar-Dukie S; Menzies Health Institute Queensland, Griffith University, Queensland, 4222, Australia; School of Pharmacy and Pharmacology, Griffith University, Gold Coast Campus, Queensland, 4222, Australia; Quality Use of Medicines Network, Queensland, 4222, Australia. Electronic address: .
Arora D; Menzies Health Institute Queensland, Griffith University, Queensland, 4222, Australia; School of Pharmacy and Pharmacology, Griffith University, Gold Coast Campus, Queensland, 4222, Australia; Quality Use of Medicines Network, Queensland, 4222, Australia. Electronic address: .
Davey AK; Menzies Health Institute Queensland, Griffith University, Queensland, 4222, Australia; School of Pharmacy and Pharmacology, Griffith University, Gold Coast Campus, Queensland, 4222, Australia; Quality Use of Medicines Network, Queensland, 4222, Australia. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2020 Jan 15; Vol. 867, pp. 172847. Date of Electronic Publication: 2019 Dec 05.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Neurodegenerative Diseases/*drug therapy
Neuroprotective Agents/*pharmacology
Sirtuin 1/*antagonists & inhibitors
Sirtuin 2/*antagonists & inhibitors
Animals ; Anti-Inflammatory Agents/therapeutic use ; Brain/drug effects ; Brain/immunology ; Brain/pathology ; Clinical Trials as Topic ; Disease Models, Animal ; Humans ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/immunology ; Neurodegenerative Diseases/pathology ; Neuroprotective Agents/therapeutic use ; Polymorphism, Single Nucleotide ; Sirtuin 1/genetics ; Sirtuin 1/immunology ; Sirtuin 1/metabolism ; Sirtuin 2/genetics ; Sirtuin 2/immunology ; Sirtuin 2/metabolism ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model.
Autorzy :
Diaz-Perdigon T; Pharmacology and Toxicology Department, Faculty of Pharmacy, University of Navarra, Pamplona, Spain.
Belloch FB; Pharmacology and Toxicology Department, Faculty of Pharmacy, University of Navarra, Pamplona, Spain.
Ricobaraza A; Gene Therapy Program CIMA, University of Navarra, IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
Elboray EE; Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.; CREST, Japan Science and Technology Agency (JST), Saitama, Japan.; Chemistry Department, Faculty of Science, South Valley University, Qena, Egypt.
Suzuki T; Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.; CREST, Japan Science and Technology Agency (JST), Saitama, Japan.; The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan.
Tordera RM; Pharmacology and Toxicology Department, Faculty of Pharmacy, University of Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
Puerta E; Pharmacology and Toxicology Department, Faculty of Pharmacy, University of Navarra, Pamplona, Spain. .; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain. .
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Źródło :
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2020 Jan; Vol. 45 (2), pp. 347-357. Date of Electronic Publication: 2019 Aug 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Aging/*metabolism
Cognitive Dysfunction/*metabolism
Sirtuin 2/*antagonists & inhibitors
Sirtuin 2/*metabolism
Aging/genetics ; Animals ; Cognitive Dysfunction/genetics ; Male ; Mice ; Mice, Transgenic ; Receptors, N-Methyl-D-Aspartate/metabolism ; Sirtuin 2/genetics
Czasopismo naukowe
Tytuł :
Enzymatic and Biological Characterization of Novel Sirtuin Modulators against Cancer.
Autorzy :
Carafa V; Dipartimento di Medicina di Precisione, Università degli Studi della Campania 'Luigi Vanvitelli', 80138 Napoli, Italy.
Poziello A; Dipartimento di Medicina di Precisione, Università degli Studi della Campania 'Luigi Vanvitelli', 80138 Napoli, Italy.
Della Torre L; Dipartimento di Medicina di Precisione, Università degli Studi della Campania 'Luigi Vanvitelli', 80138 Napoli, Italy.
Giovannelli P; Dipartimento di Medicina di Precisione, Università degli Studi della Campania 'Luigi Vanvitelli', 80138 Napoli, Italy.
Di Donato M; Dipartimento di Medicina di Precisione, Università degli Studi della Campania 'Luigi Vanvitelli', 80138 Napoli, Italy.
Safadeh E; Dipartimento di Medicina di Precisione, Università degli Studi della Campania 'Luigi Vanvitelli', 80138 Napoli, Italy.
Yu Z; Dipartimento di Medicina di Precisione, Università degli Studi della Campania 'Luigi Vanvitelli', 80138 Napoli, Italy.
Baldi A; Dipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche Università degli Studi della Campania 'Luigi Vanvitelli', 81100 Caserta, Italy.
Castoria G; Dipartimento di Medicina di Precisione, Università degli Studi della Campania 'Luigi Vanvitelli', 80138 Napoli, Italy.
Tomaselli D; Dipartimento di Chimica e Tecnologie del Farmaco 'Sapienza' Università di Roma, 00185 Roma, Italy.
Mai A; Dipartimento di Chimica e Tecnologie del Farmaco 'Sapienza' Università di Roma, 00185 Roma, Italy.
Rotili D; Dipartimento di Chimica e Tecnologie del Farmaco 'Sapienza' Università di Roma, 00185 Roma, Italy.
Nebbioso A; Dipartimento di Medicina di Precisione, Università degli Studi della Campania 'Luigi Vanvitelli', 80138 Napoli, Italy.
Altucci L; Dipartimento di Medicina di Precisione, Università degli Studi della Campania 'Luigi Vanvitelli', 80138 Napoli, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Nov 12; Vol. 20 (22). Date of Electronic Publication: 2019 Nov 12.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Histone Deacetylase Inhibitors*/chemistry
Histone Deacetylase Inhibitors*/pharmacology
Neoplasm Proteins*/antagonists & inhibitors
Neoplasm Proteins*/metabolism
Neoplasms*/drug therapy
Neoplasms*/enzymology
Neoplasms*/pathology
Sirtuin 1*/antagonists & inhibitors
Sirtuin 1*/metabolism
Sirtuin 2*/antagonists & inhibitors
Sirtuin 2*/metabolism
Animals ; HL-60 Cells ; Humans ; K562 Cells ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molybdoferredoxin ; U937 Cells
Czasopismo naukowe
Tytuł :
Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies.
Autorzy :
Chowdhury S; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Sripathy S; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Webster A; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Park A; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Lao U; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Hsu JH; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Loe T; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Bedalov A; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Simon JA; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Jan 21; Vol. 25 (3). Date of Electronic Publication: 2020 Jan 21.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Antineoplastic Agents/*therapeutic use
Lymphoma, B-Cell/*drug therapy
Sirtuin 2/*antagonists & inhibitors
Acetylation ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Death/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; Inhibitory Concentration 50 ; Mice ; Sirtuin 2/metabolism ; Structure-Activity Relationship ; Tubulin/metabolism
Czasopismo naukowe
Tytuł :
Intracellular Control of β-Catenin and Intestinal Cell Fate by SIRT2.
Autorzy :
Frey MR; Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California; Department of Pediatrics and Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California. Electronic address: .
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Źródło :
Cellular and molecular gastroenterology and hepatology [Cell Mol Gastroenterol Hepatol] 2020; Vol. 10 (1), pp. 193-194. Date of Electronic Publication: 2020 Mar 06.
Typ publikacji :
Editorial; Research Support, N.I.H., Extramural; Comment
MeSH Terms :
Sirtuin 2*
beta Catenin*
Cell Differentiation ; Cell Proliferation ; Intestines
Raport
Tytuł :
Distinct role of Sirtuin 1 (SIRT1) and Sirtuin 2 (SIRT2) in inhibiting cargo-loading and release of extracellular vesicles.
Autorzy :
Lee BR; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Sanstrum BJ; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Liu Y; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Kwon SH; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA. .
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Źródło :
Scientific reports [Sci Rep] 2019 Dec 27; Vol. 9 (1), pp. 20049. Date of Electronic Publication: 2019 Dec 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Extracellular Vesicles/*metabolism
Sirtuin 1/*physiology
Sirtuin 2/*physiology
Acetylation ; HEK293 Cells ; Humans ; Mannose-Binding Lectins/metabolism ; Membrane Transport Proteins/metabolism ; Protein Binding ; Protein Transport ; Receptors, G-Protein-Coupled/metabolism ; Sirtuin 1/genetics ; Sirtuin 2/genetics
Czasopismo naukowe
Tytuł :
Post-Stroke Microglia Induce Sirtuin2 Expression to Suppress the Anti-inflammatory Function of Infiltrating Regulatory T Cells.
Autorzy :
Shu L; Department of Neurology, Affiliated Renhe Hospital of China Three Gorges University, Yichang City, 443000, Hubei Province, China.
Xu CQ; Department of Neurology, Affiliated Renhe Hospital of China Three Gorges University, Yichang City, 443000, Hubei Province, China.
Yan ZY; Department of Neurology, Affiliated Renhe Hospital of China Three Gorges University, Yichang City, 443000, Hubei Province, China.
Yan Y; Department of Neurology, Affiliated Renhe Hospital of China Three Gorges University, Yichang City, 443000, Hubei Province, China.
Jiang SZ; Department of Digestive Diseases, Affiliated Renhe Hospital of China Three Gorges University, Yichang City, 443000, Hubei Province, China.
Wang YR; Department of Neurology, Affiliated Renhe Hospital of China Three Gorges University, Yichang City, 443000, Hubei Province, China. .
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Źródło :
Inflammation [Inflammation] 2019 Dec; Vol. 42 (6), pp. 1968-1979.
Typ publikacji :
Journal Article
MeSH Terms :
Inflammation/*etiology
Microglia/*physiology
Sirtuin 2/*metabolism
Stroke/*pathology
T-Lymphocytes, Regulatory/*immunology
Animals ; Brain Ischemia/metabolism ; Brain Ischemia/pathology ; Cell Communication/immunology ; Disease Models, Animal ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Infarction, Middle Cerebral Artery ; Mice ; Sirtuin 2/physiology ; T-Lymphocytes, Regulatory/metabolism
Czasopismo naukowe
Tytuł :
Dual Deletion of the Sirtuins SIRT2 and SIRT3 Impacts on Metabolism and Inflammatory Responses of Macrophages and Protects From Endotoxemia.
Autorzy :
Heinonen T; Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Ciarlo E; Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Rigoni E; Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Regina J; Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Le Roy D; Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Roger T; Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
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Źródło :
Frontiers in immunology [Front Immunol] 2019 Nov 26; Vol. 10, pp. 2713. Date of Electronic Publication: 2019 Nov 26 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endotoxemia/*metabolism
Inflammation/*metabolism
Macrophages/*physiology
Sirtuin 2/*metabolism
Sirtuin 3/*metabolism
Animals ; Cells, Cultured ; Female ; Immune Tolerance ; Immunity, Innate ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Sirtuin 2/genetics ; Sirtuin 3/genetics
Czasopismo naukowe
Tytuł :
Design, synthesis, in-vitro evaluation and molecular docking studies of novel indole derivatives as inhibitors of SIRT1 and SIRT2.
Autorzy :
Manjula R; Department of Biophysics, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore 560029, India.
Gokhale N; Organic Chemistry Laboratory, Department of Chemistry, National Institute of Technology Karnataka, Surathkal, Srinivasanagar, Mangalore 575025, India.
Unni S; Department of Biophysics, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore 560029, India.
Deshmukh P; Department of Biophysics, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore 560029, India.
Reddyrajula R; Organic Chemistry Laboratory, Department of Chemistry, National Institute of Technology Karnataka, Surathkal, Srinivasanagar, Mangalore 575025, India.
Srinivas Bharath MM; Department of Clinical Psychopharmacology and Neurotoxicology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore 560029, India.
Dalimba U; Organic Chemistry Laboratory, Department of Chemistry, National Institute of Technology Karnataka, Surathkal, Srinivasanagar, Mangalore 575025, India. Electronic address: .
Padmanabhan B; Department of Biophysics, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore 560029, India. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2019 Nov; Vol. 92, pp. 103281. Date of Electronic Publication: 2019 Sep 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Molecular Docking Simulation*
Histone Deacetylase Inhibitors/*pharmacology
Indoles/*pharmacology
Sirtuin 1/*antagonists & inhibitors
Sirtuin 2/*antagonists & inhibitors
Dose-Response Relationship, Drug ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Humans ; Indoles/chemical synthesis ; Indoles/chemistry ; Molecular Structure ; Sirtuin 1/metabolism ; Sirtuin 2/metabolism ; Structure-Activity Relationship ; Surface Plasmon Resonance
Czasopismo naukowe
Tytuł :
SIRT2: Controversy and multiple roles in disease and physiology.
Autorzy :
Wang Y; Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China; Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.
Yang J; Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Hong T; Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Chen X; Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Cui L; Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. Electronic address: .
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Źródło :
Ageing research reviews [Ageing Res Rev] 2019 Nov; Vol. 55, pp. 100961. Date of Electronic Publication: 2019 Sep 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Sirtuin 2/*physiology
Animals ; Autophagy ; Cell Differentiation ; Genomic Instability ; Humans ; Inflammation ; Mitosis ; Neoplasms/metabolism ; Neurodegenerative Diseases/metabolism ; Oxidative Stress ; Sirtuin 2/metabolism
Czasopismo naukowe

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