Oligodendrocyte-derived exosomes-containing SIRT2 ameliorates depressive-like behaviors and restores hippocampal neurogenesis and synaptic plasticity via the AKT/GSK-3β pathway in depressed mice.
Autorzy:
Zhang H; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. Xie XH; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. Xu SX; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. Wang C; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. Sun S; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. Song X; Clinical College of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, China. Li R; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. Li N; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. Feng Y; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. Duan H; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. Li D; Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Liu Z; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.; Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China.
Bioinformatic identification and experiment validation reveal 6 hub genes, promising diagnostic and therapeutic targets for Alzheimer's disease.
Autorzy:
Cao W; Department of Neurology Second Ward, Zibo Municipal Hospital, No. 139, Huangong Road, Linzi District, Zibo City, 255400, Shandong Province, China. Ji Z; Department of Neurology Second Ward, Zibo Municipal Hospital, No. 139, Huangong Road, Linzi District, Zibo City, 255400, Shandong Province, China. Zhu S; Department of Neurology Second Ward, Zibo Municipal Hospital, No. 139, Huangong Road, Linzi District, Zibo City, 255400, Shandong Province, China. Wang M; Department of Rehabilitation, Zibo Municipal Hospital, No. 139, Huangong Road, Linzi District, Zibo City, 255400, Shandong Province, China. Sun R; Department of Neurology Second Ward, Zibo Municipal Hospital, No. 139, Huangong Road, Linzi District, Zibo City, 255400, Shandong Province, China. .
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Źródło:
BMC medical genomics [BMC Med Genomics] 2024 Jan 02; Vol. 17 (1), pp. 6. Date of Electronic Publication: 2024 Jan 02.
SIRT2 transgenic over-expression does not impact lifespan in mice.
Autorzy:
Wu LE; School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia. Fiveash CE; School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia. Bentley NL; School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia. Kang MJ; School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia. Govindaraju H; School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.; Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia. Barbour JA; School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia. Wilkins BP; School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia. Hancock SE; Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia. Madawala R; School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia. Das A; School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.; School of Psychology, UNSW Sydney, Kensington, New South Wales, Australia. Massudi H; School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia. Li C; School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia. Kim LJ; School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia. Wong ASA; School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia. Marinova MB; School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia. Sultani G; School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia. Das A; School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia. Youngson NA; School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia. Le Couteur DG; ANZAC Medical Research Institute, Concord, New South Wales, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia. Sinclair DA; Department of Genetics, Blavatnik Institute, Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School, Boston, Massachusetts, United States. Turner N; School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.; Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
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Źródło:
Aging cell [Aging Cell] 2023 Dec; Vol. 22 (12), pp. e14027. Date of Electronic Publication: 2023 Nov 27.
5-((3-Amidobenzyl)oxy)nicotinamides as SIRT2 Inhibitors: A Study of Constrained Analogs.
Autorzy:
Ai T; Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. Wilson DJ; Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. Chen L; Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
Cooperative effects of SIRT1 and SIRT2 on APP acetylation.
Autorzy:
Li N; Department of Gerontology and Geriatrics, Shengjing Hospital, China Medical University, Shenyang, China. Bai N; The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, China.; Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, China. Zhao X; The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, China.; Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, China. Cheng R; The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, China.; Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, China. Wu X; The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, China.; Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, China. Jiang B; The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, China.; Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, China. Li X; The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, China.; Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, China. Xue M; Department of Ophthalmology, the First Affiliated Hospital of China Medical University, Shenyang, China. Xu H; The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, China.; Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, China. Guo Q; The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, China.; Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, China. Guo W; The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, China.; Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, China. Ma M; The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, China.; Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, China. Cao S; The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, China.; Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, China. Feng Y; The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, China.; Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, China. Song X; The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, China.; Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, China. Wang Z; Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, China. Zhang X; Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China. Zou Y; Department of Histology and Embryology, The College of Basic Medical Science, China Medical University, Shenyang, China. Wang D; Department of Gerontology and Geriatrics, Shengjing Hospital, China Medical University, Shenyang, China. Liu H; Innovation Center of Aging-Related Disease Diagnosis and Treatment and Prevention, Jinzhou Medical University, Jinzhou, China. Cao L; The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, China.; Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, China.; Innovation Center of Aging-Related Disease Diagnosis and Treatment and Prevention, Jinzhou Medical University, Jinzhou, China.
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Źródło:
Aging cell [Aging Cell] 2023 Oct; Vol. 22 (10), pp. e13967. Date of Electronic Publication: 2023 Aug 21.
An EMT-related genes signature as a prognostic biomarker for patients with endometrial cancer.
Autorzy:
Yu Y; State Key Lab of Respiratory Disease, Institute for Chemical Carcinogenesis, Collaborative Innovation Center for Environmental Toxicity, School of Public Health, Guangzhou Medical University, 1 Xinzao Road, Xinzao, Panyu District, Guangzhou, 511436, China. Zhang Y; Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. Li Z; State Key Lab of Respiratory Disease, Institute for Chemical Carcinogenesis, Collaborative Innovation Center for Environmental Toxicity, School of Public Health, Guangzhou Medical University, 1 Xinzao Road, Xinzao, Panyu District, Guangzhou, 511436, China. Dong Y; State Key Lab of Respiratory Disease, Institute for Chemical Carcinogenesis, Collaborative Innovation Center for Environmental Toxicity, School of Public Health, Guangzhou Medical University, 1 Xinzao Road, Xinzao, Panyu District, Guangzhou, 511436, China. Huang H; State Key Lab of Respiratory Disease, Institute for Chemical Carcinogenesis, Collaborative Innovation Center for Environmental Toxicity, School of Public Health, Guangzhou Medical University, 1 Xinzao Road, Xinzao, Panyu District, Guangzhou, 511436, China. Yang B; Innovation Center for Advanced Interdisciplinary Medicine, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. Zhao E; Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou, Guangdong, China. Chen Y; Department of Gynaecology and Obstetrics, Guangdong Women's and Children's Hospital, Guangzhou, Guangdong, China. Yang L; State Key Lab of Respiratory Disease, Institute for Chemical Carcinogenesis, Collaborative Innovation Center for Environmental Toxicity, School of Public Health, Guangzhou Medical University, 1 Xinzao Road, Xinzao, Panyu District, Guangzhou, 511436, China. Lu J; State Key Lab of Respiratory Disease, Institute for Chemical Carcinogenesis, Collaborative Innovation Center for Environmental Toxicity, School of Public Health, Guangzhou Medical University, 1 Xinzao Road, Xinzao, Panyu District, Guangzhou, 511436, China. Qiu F; State Key Lab of Respiratory Disease, Institute for Chemical Carcinogenesis, Collaborative Innovation Center for Environmental Toxicity, School of Public Health, Guangzhou Medical University, 1 Xinzao Road, Xinzao, Panyu District, Guangzhou, 511436, China. .
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Źródło:
BMC cancer [BMC Cancer] 2023 Sep 18; Vol. 23 (1), pp. 879. Date of Electronic Publication: 2023 Sep 18.
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