Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Ukraiński (UK)
Przejdź do strony domowej biblioteki Uniwersytet Ekonomiczny we Wrocławiu Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaUniwersytet Ekonomiczny we Wrocławiu

Wyszukujesz frazę ""Sleegers, K."" wg kryterium: Autor

  Lista filtrów
Wyrównaj
Wyświetlanie 1-20 z 31
Tytuł:
Definition of a Threshold for the Plasma Aβ42/Aβ40 Ratio Measured by Single-Molecule Array to Predict the Amyloid Status of Individuals without Dementia.
Autorzy:
Colmant L; Institute of Neuroscience, UCLouvain, 1200 Brussels, Belgium.; Neurology Department, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium.; Institute of Information and Communication Technologies, Electronics and Applied Mathematics, UCLouvain, 1348 Louvain-la-Neuve, Belgium.
Boyer E; Institute of Neuroscience, UCLouvain, 1200 Brussels, Belgium.; Neurology Department, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium.
Gerard T; Institute of Neuroscience, UCLouvain, 1200 Brussels, Belgium.; Neurology Department, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium.
Sleegers K; Complex Genetics of Alzheimer's Disease Group, VIB-UAntwerp Center for Molecular Neurology, University of Antwerp, 2000 Antwerpen, Belgium.
Lhommel R; Neurology Department, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium.
Ivanoiu A; Institute of Neuroscience, UCLouvain, 1200 Brussels, Belgium.; Neurology Department, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium.
Lefèvre P; Institute of Neuroscience, UCLouvain, 1200 Brussels, Belgium.; Institute of Information and Communication Technologies, Electronics and Applied Mathematics, UCLouvain, 1348 Louvain-la-Neuve, Belgium.
Kienlen-Campard P; Institute of Neuroscience, UCLouvain, 1200 Brussels, Belgium.
Hanseeuw B; Institute of Neuroscience, UCLouvain, 1200 Brussels, Belgium.; Neurology Department, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium.; WELBIO Department, WEL Research Institute, Avenue Pasteur, 6, 1300 Wavre, Belgium.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 18; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 18.
Typ publikacji:
Journal Article
MeSH Terms:
Amyloid beta-Peptides*
Alzheimer Disease*/diagnosis
Humans ; Amyloidogenic Proteins ; Positron-Emission Tomography ; Brain ; Plaque, Amyloid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response.
Autorzy:
Duchateau L; Complex Genetics of Alzheimer's Disease Group, VIB-UAntwerp Center for Molecular Neurology, VIB, Building V, Universiteitsplein 1, Wilrijk, Antwerp, B-2610, Belgium.; Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, Wilrijk, Antwerp, 2610, Belgium.
Küҫükali F; Complex Genetics of Alzheimer's Disease Group, VIB-UAntwerp Center for Molecular Neurology, VIB, Building V, Universiteitsplein 1, Wilrijk, Antwerp, B-2610, Belgium.; Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, Wilrijk, Antwerp, 2610, Belgium.
De Roeck A; Complex Genetics of Alzheimer's Disease Group, VIB-UAntwerp Center for Molecular Neurology, VIB, Building V, Universiteitsplein 1, Wilrijk, Antwerp, B-2610, Belgium.; Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, Wilrijk, Antwerp, 2610, Belgium.; Present Address: Argenx, Ghent, Belgium.
Wittens MMJ; Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, Wilrijk, Antwerp, 2610, Belgium.; Clinical Neurochemistry Laboratory, Department of Clinical Biology, University Hospital Brussels, Generaal Jacqueslaan 137, Elsene, Brussels, 1050, Belgium.
Temmerman J; Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, Wilrijk, Antwerp, 2610, Belgium.; Neuroprotection & Neuromodulation (NEUR) Research Group, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, Jette, Brussels, 1090, Belgium.
Weets I; Clinical Neurochemistry Laboratory, Department of Clinical Biology, University Hospital Brussels, Generaal Jacqueslaan 137, Elsene, Brussels, 1050, Belgium.; Experimental Pharmacology (EFAR) Research Group, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, Brussels, 1090, Belgium.
Timmers M; Reference Center for Biological Markers of Dementia, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, Wilrijk, Antwerp, 2610, Belgium.; Janssen Research and Development, a Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse, 2340, Belgium.
Engelborghs S; Neuroprotection & Neuromodulation (NEUR) Research Group, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, Jette, Brussels, 1090, Belgium.; Reference Center for Biological Markers of Dementia, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, Wilrijk, Antwerp, 2610, Belgium.; Department of Neurology and Bru-BRAIN, University Hospital Brussels, Generaal Jacqueslaan 137, Elsene, Brussels, 1050, Belgium.
Bjerke M; Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, Wilrijk, Antwerp, 2610, Belgium.; Clinical Neurochemistry Laboratory, Department of Clinical Biology, University Hospital Brussels, Generaal Jacqueslaan 137, Elsene, Brussels, 1050, Belgium.; Neuroprotection & Neuromodulation (NEUR) Research Group, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, Jette, Brussels, 1090, Belgium.
Sleegers K; Complex Genetics of Alzheimer's Disease Group, VIB-UAntwerp Center for Molecular Neurology, VIB, Building V, Universiteitsplein 1, Wilrijk, Antwerp, B-2610, Belgium. kristel.sleegers@uantwerpen.vib.be.; Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, Wilrijk, Antwerp, 2610, Belgium. kristel.sleegers@uantwerpen.vib.be.
Pokaż więcej
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2023 Nov 09; Vol. 15 (1), pp. 195. Date of Electronic Publication: 2023 Nov 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/pathology
Humans ; ATP-Binding Cassette Transporters/genetics ; Biomarkers ; Chitinase-3-Like Protein 1/metabolism ; Codon, Nonsense ; Mutation/genetics ; Amyloid/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning.
Autorzy:
Neumann A; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam, Netherlands.
Ohlei O; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Ratzeburger Allee 160, V50.2M, Lübeck, 23562, Germany.
Küçükali F; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Bos IJ; Netherlands Institute for Health Services Research, Utrecht, Netherlands.
Timsina J; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA.
Vos S; Alzheimer Centrum Limburg, Maastricht University, Maastricht, Netherlands.
Prokopenko D; Genetics and Aging Unit and McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Tijms BM; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.
Andreasson U; Department of Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Blennow K; Department of Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Vandenberghe R; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium.; Neurology Service, University Hospital Leuven, Leuven, Belgium.
Scheltens P; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.
Teunissen CE; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.
Engelborghs S; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Universitair Ziekenhuis Brussel (UZ Brussel) and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Frisoni GB; Memory Center, Department of Rehabilitation and Geriatrics, Geneva University and University Hospitals, Geneva, Switzerland.
Blin O; Clinical Pharmacology & Pharmacovigilance Department, Marseille University Hospital, Marseille, France.
Richardson JC; Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, UK.
Bordet R; Neuroscience & Cognition, CHU de Lille, University of Lille, Inserm, France.
Lleó A; Memory Unit, Neurology Department, Hospital de Sant Pau, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Alcolea D; Memory Unit, Neurology Department, Hospital de Sant Pau, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Popp J; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zürich, Zurich, Switzerland.; Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.
Marsh TW; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA.; Division of Biology & Biomedical Sciences, Washington University in St. Louis, St Louis, MO, USA.
Gorijala P; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA.
Clark C; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zürich, Zurich, Switzerland.
Peyratout G; Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.
Martinez-Lage P; Center for Research and Advanced Therapies, CITA-Alzheimer Foundation, San Sebastian, Spain.
Tainta M; Center for Research and Advanced Therapies, CITA-Alzheimer Foundation, San Sebastian, Spain.; Zumarraga Hospital, Osakidetza, Integrated Health Organization (OSI) Goierri-Urola Garia, Basque Country, Spain.
Dobson RJB; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Boston, UK.; NIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.; Health Data Research UK London, University College London, London, UK.; Institute of Health Informatics, University College London, London, UK.; The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK.
Legido-Quigley C; Steno Diabetes Center, Copenhagen, Denmark.; Institute of Pharmaceutical Science, King's College London, London, UK.
Van Broeckhoven C; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
Tanzi RE; Genetics and Aging Unit and McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Ten Kate M; Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, Netherlands.; Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands.
Lill CM; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Ratzeburger Allee 160, V50.2M, Lübeck, 23562, Germany.; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.; Ageing Epidemiology Research Unit, School of Public Health, Imperial College, London, UK.
Barkhof F; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands.; Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London, London, UK.
Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA.
Lovestone S; Janssen Medical Ltd, Wycombe, UK.; Department of Psychiatry, University of Oxford, Oxford, UK.
Streffer J; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; AC Immune SA, Lausanne, Switzerland.; Janssen R&D, LLC, Beerse, Belgium.
Zetterberg H; Department of Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; UK Dementia Research Institute, University College London, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
Visser PJ; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; Alzheimer Centrum Limburg, Maastricht University, Maastricht, Netherlands.; Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, Netherlands.
Sleegers K; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Bertram L; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Ratzeburger Allee 160, V50.2M, Lübeck, 23562, Germany. .; Centre for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway. .
Pokaż więcej
Corporate Authors:
EMIF-AD & ADNI study group
Źródło:
Genome medicine [Genome Med] 2023 Oct 04; Vol. 15 (1), pp. 79. Date of Electronic Publication: 2023 Oct 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/pathology
Humans ; Female ; Male ; Genome-Wide Association Study ; tau Proteins/genetics ; Biomarkers ; Inflammation ; Apolipoproteins E/genetics ; Membrane Proteins/genetics ; Nerve Tissue Proteins/genetics ; Receptors, N-Methyl-D-Aspartate/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TDP-43 pathology is associated with increased tau burdens and seeding.
Autorzy:
Tomé SO; Laboratory of Neuropathology - Department of Imaging and Pathology, KU Leuven, Leuven, Belgium. .; Leuven Brain Institute, KU Leuven, Leuven, Belgium. .
Tsaka G; Laboratory of Neuropathology - Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.; Leuven Brain Institute, KU Leuven, Leuven, Belgium.; Switch Laboratory, VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Ronisz A; Laboratory of Neuropathology - Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.; Leuven Brain Institute, KU Leuven, Leuven, Belgium.
Ospitalieri S; Laboratory of Neuropathology - Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.; Leuven Brain Institute, KU Leuven, Leuven, Belgium.
Gawor K; Laboratory of Neuropathology - Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.; Leuven Brain Institute, KU Leuven, Leuven, Belgium.
Gomes LA; Laboratory of Neuropathology - Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.; Leuven Brain Institute, KU Leuven, Leuven, Belgium.
Otto M; Department of Neurology, University of Ulm, Ulm, Germany.; Department of Neurology, University of Halle, Halle, Germany.
von Arnim CAF; Department of Neurology, University of Ulm, Ulm, Germany.; Department of Geriatrics, University Medical Center Göttingen, Göttingen, Germany.
Van Damme P; Leuven Brain Institute, KU Leuven, Leuven, Belgium.; Laboratory for Neurobiology - VIB-KU Leuven, Leuven, Belgium.; Department of Neurology, UZ Leuven, Leuven, Belgium.
Van Den Bosch L; Leuven Brain Institute, KU Leuven, Leuven, Belgium.; Laboratory for Neurobiology - VIB-KU Leuven, Leuven, Belgium.
Ghebremedhin E; Institute for Clinical Neuroanatomy - Johann Wolfgang Goethe University, Frankfurt Am Main, Germany.
Laureyssen C; Complex Genetics of Alzheimer's Disease Group, VIB-University of Antwerp Center for Molecular Neurology, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Sleegers K; Complex Genetics of Alzheimer's Disease Group, VIB-University of Antwerp Center for Molecular Neurology, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Vandenberghe R; Leuven Brain Institute, KU Leuven, Leuven, Belgium.; Department of Neurology, UZ Leuven, Leuven, Belgium.; Laboratory of Experimental Neurology - Department of Neurosciences, KU Leuven, Leuven, Belgium.
Rousseau F; Switch Laboratory, VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Schymkowitz J; Switch Laboratory, VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Thal DR; Laboratory of Neuropathology - Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.; Leuven Brain Institute, KU Leuven, Leuven, Belgium.; Department of Pathology, UZ Leuven, Leuven, Belgium.
Pokaż więcej
Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2023 Sep 30; Vol. 18 (1), pp. 71. Date of Electronic Publication: 2023 Sep 30.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/metabolism
TDP-43 Proteinopathies*/metabolism
Humans ; Animals ; Mice ; tau Proteins/metabolism ; Neurofibrillary Tangles/metabolism ; DNA-Binding Proteins/metabolism
SCR Disease Name:
limbic-predominant age-related TDP-43 encephalopathy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Correction: Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease.
Autorzy:
Visser PJ; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, PO Box 7057 1007, MB, Amsterdam, The Netherlands. .; Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200, MD, Maastricht, The Netherlands. .; Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden. .
Reus LM; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, PO Box 7057 1007, MB, Amsterdam, The Netherlands.
Gobom J; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Jansen I; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, the Netherlands.
Dicks E; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, PO Box 7057 1007, MB, Amsterdam, The Netherlands.
van der Lee SJ; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, PO Box 7057 1007, MB, Amsterdam, The Netherlands.; Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
Tsolaki M; 1St Department of Neurology, AHEPA University Hospital, Thessaloniki, Makedonia, Greece.
Verhey FRJ; Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200, MD, Maastricht, The Netherlands.
Popp J; Old Age Psychiatry, University Hospital Lausanne, Lausanne, Switzerland.; Department of Geriatric Psychiatry, University Hospital of Psychiatry and University of Zürich, Zürich, Switzerland.
Martinez-Lage P; Fundación CITA-Alzhéimer Fundazioa, San Sebastian, Spain.
Vandenberghe R; Neurology Service, University Hospitals Leuven, Leuven, Belgium.; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium.
Lleó A; IIB-Sant Pau, Hospital de La Santa Creu I Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.
Molinuevo JL; Barcelonaβeta Brain Research Center (BBRC), Barcelona, Spain.; Alzheimer's Disease Unit and Other Cognitive Disorders Unit, Hospital Clinic de Barcelona, Barcelona, Spain.
Engelborghs S; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology, UZ Brussel and Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.
Freund-Levi Y; Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.; Department of Psychiatry at School of Medical Sciences, Örebro University, Örebro, Sweden.
Froelich L; Department of Geriatric Psychiatry, Zentralinstitut Für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany.
Sleegers K; Complex Genetics Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Dobricic V; Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany.
Lovestone S; Jansen UK, High Wycombe, UK.
Streffer J; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; AC Immune SA, Lausanne, Switzerland.
Vos SJB; Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200, MD, Maastricht, The Netherlands.
Bos I; Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200, MD, Maastricht, The Netherlands.
Smit AB; Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Blennow K; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Scheltens P; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, PO Box 7057 1007, MB, Amsterdam, The Netherlands.
Teunissen CE; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Centers (AUMC), Amsterdam Neuroscience, Amsterdam, Netherlands.
Bertram L; Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany.; Center for Lifespan Changes in Brain and Cognition, Dept. of Psychology, University of Oslo, Oslo, Norway.
Zetterberg H; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; Dementia Research Institute at UCL, London, UK.
Tijms BM; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, PO Box 7057 1007, MB, Amsterdam, The Netherlands.
Pokaż więcej
Corporate Authors:
ADNI
Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2022 May 13; Vol. 17 (1), pp. 37. Date of Electronic Publication: 2022 May 13.
Typ publikacji:
Published Erratum
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease.
Autorzy:
Visser PJ; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, PO Box 7057 1007, MB, Amsterdam, The Netherlands. .; Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200, MD, Maastricht, The Netherlands. .; Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden. .
Reus LM; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, PO Box 7057 1007, MB, Amsterdam, The Netherlands.
Gobom J; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Jansen I; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, the Netherlands.
Dicks E; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, PO Box 7057 1007, MB, Amsterdam, The Netherlands.
van der Lee SJ; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, PO Box 7057 1007, MB, Amsterdam, The Netherlands.; Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
Tsolaki M; 1St Department of Neurology, AHEPA University Hospital, Thessaloniki, Makedonia, Greece.
Verhey FRJ; Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200, MD, Maastricht, The Netherlands.
Popp J; Old Age Psychiatry, University Hospital Lausanne, Lausanne, Switzerland.; Department of Geriatric Psychiatry, University Hospital of Psychiatry and University of Zürich, Zürich, Switzerland.
Martinez-Lage P; Fundación CITA-Alzhéimer Fundazioa, San Sebastian, Spain.
Vandenberghe R; Neurology Service, University Hospitals Leuven, Leuven, Belgium.; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium.
Lleó A; IIB-Sant Pau, Hospital de La Santa Creu I Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.
Molinuevo JL; Barcelonaβeta Brain Research Center (BBRC), Barcelona, Spain.; Alzheimer's Disease Unit and Other Cognitive Disorders Unit, Hospital Clinic de Barcelona, Barcelona, Spain.
Engelborghs S; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology, UZ Brussel and Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.
Freund-Levi Y; Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.; Department of Psychiatry at School of Medical Sciences, Örebro University, Örebro, Sweden.
Froelich L; Department of Geriatric Psychiatry, Zentralinstitut Für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany.
Sleegers K; Complex Genetics Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Dobricic V; Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany.
Lovestone S; Jansen UK, High Wycombe, UK.
Streffer J; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; AC Immune SA, Lausanne, Switzerland.
Vos SJB; Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200, MD, Maastricht, The Netherlands.
Bos I; Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200, MD, Maastricht, The Netherlands.
Smit AB; Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Blennow K; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Scheltens P; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, PO Box 7057 1007, MB, Amsterdam, The Netherlands.
Teunissen CE; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Centers (AUMC), Amsterdam Neuroscience, Netherlands.
Bertram L; Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany.; Center for Lifespan Changes in Brain and Cognition, Dept. of Psychology, University of Oslo, Oslo, Norway.
Zetterberg H; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; Dementia Research Institute at UCL, London, UK.
Tijms BM; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, PO Box 7057 1007, MB, Amsterdam, The Netherlands.
Pokaż więcej
Corporate Authors:
ADNI
Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2022 Mar 28; Vol. 17 (1), pp. 27. Date of Electronic Publication: 2022 Mar 28.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/cerebrospinal fluid
Alzheimer Disease*/pathology
Neuronal Plasticity*
tau Proteins*/cerebrospinal fluid
Biomarkers/cerebrospinal fluid ; Humans ; Proteomics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping.
Autorzy:
Belloy ME; Department of Neurology and Neurological Sciences - Greicius lab, Stanford University, 290 Jane Stanford Way, Stanford, CA, 94304, USA. .
Eger SJ; Department of Neurology and Neurological Sciences - Greicius lab, Stanford University, 290 Jane Stanford Way, Stanford, CA, 94304, USA.
Le Guen Y; Department of Neurology and Neurological Sciences - Greicius lab, Stanford University, 290 Jane Stanford Way, Stanford, CA, 94304, USA.
Damotte V; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.
Ahmad S; Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands.; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Ikram MA; Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands.
Ramirez A; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Neurodegenerative diseases and Geriatric Psychiatry, Medical Faculty, University Hospital Bonn, Bonn, Germany.; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Tsolaki AC; 1st Department of Neurology, AHEPA Hospital, Aristotle University of Thessaloniki, Athens, Greece.
Rossi G; Unit of Neurology V and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Jansen IE; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije University, Amsterdam, The Netherlands.
de Rojas I; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Parveen K; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Neurodegenerative diseases and Geriatric Psychiatry, Medical Faculty, University Hospital Bonn, Bonn, Germany.
Sleegers K; Complex Genetics of Alzheimer's Disease Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Ingelsson M; Department of Public Health and Carins Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Yliopistonranta 1E, 70211, Kuopio, Finland.
Amin N; Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands.; Nuffield Department of Population Health Oxford University, Oxford, UK.
Andreassen O; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Sánchez-Juan P; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain.
Kehoe P; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Amouyel P; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.
Sims R; Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales, UK.
Frikke-Schmidt R; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
van der Flier WM; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Lambert JC; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.
He Z; Department of Neurology and Neurological Sciences - Greicius lab, Stanford University, 290 Jane Stanford Way, Stanford, CA, 94304, USA.; Quantitative Sciences Unit, Department of Medicine, Stanford University, Stanford, CA, 94304, USA.
Han SS; Quantitative Sciences Unit, Department of Medicine, Stanford University, Stanford, CA, 94304, USA.; Department of Neurosurgery, Stanford University, Stanford, CA, 94304, USA.
Napolioni V; School of Biosciences and Veterinary Medicine, University of Camerino, 62032, Camerino, Italy.
Greicius MD; Department of Neurology and Neurological Sciences - Greicius lab, Stanford University, 290 Jane Stanford Way, Stanford, CA, 94304, USA.
Pokaż więcej
Corporate Authors:
European Alzheimer & Dementia BioBank (EADB)
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2022 Feb 04; Vol. 14 (1), pp. 22. Date of Electronic Publication: 2022 Feb 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/genetics
Apolipoproteins E*/genetics
Apolipoprotein E4/genetics ; Genetic Predisposition to Disease/genetics ; Genotype ; Humans ; Middle Aged ; Quality Control
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Amyloid-β 1-43 cerebrospinal fluid levels and the interpretation of APP, PSEN1 and PSEN2 mutations.
Autorzy:
Perrone F; Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, Antwerp, Belgium.; Institute Born-Bunge, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Bjerke M; Institute Born-Bunge, Antwerp, Belgium.; Reference Centre for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Laboratory of Neurochemistry and Center for Neurosciences, UZ Brussel and Vrije Universiteit Brussel, Brussels, Belgium.
Hens E; Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, Antwerp, Belgium.; Institute Born-Bunge, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Middelheim and Hoge Beuken, Antwerp, Belgium.; Department of Neurology, University Hospital Antwerp, Edegem, Belgium.; Department of Neurology, University Hospital Brussel and Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.
Sieben A; Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, Antwerp, Belgium.; Institute Born-Bunge, Antwerp, Belgium.; Department of Neurology, University Hospital Ghent and University of Ghent, Ghent, Belgium.
Timmers M; Reference Centre for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Janssen Research and Development, Division of Janssen Pharmaceutica NV, Beerse, Belgium.
De Roeck A; Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, Antwerp, Belgium.; Institute Born-Bunge, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Vandenberghe R; Department of Neurosciences, Faculty of Medicine, KU Leuven, Louvain, Belgium.; Laboratory of Cognitive Neurology, Department of Neurology, University Hospitals Leuven, Louvain, Belgium.
Sleegers K; Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, Antwerp, Belgium.; Institute Born-Bunge, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Martin JJ; Institute Born-Bunge, Antwerp, Belgium.
De Deyn PP; Institute Born-Bunge, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Middelheim and Hoge Beuken, Antwerp, Belgium.
Engelborghs S; Reference Centre for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology, University Hospital Brussel and Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.
van der Zee J; Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, Antwerp, Belgium.; Institute Born-Bunge, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Van Broeckhoven C; Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, Antwerp, Belgium. .; Institute Born-Bunge, Antwerp, Belgium. .; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. .
Cacace R; Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, Antwerp, Belgium. .; Institute Born-Bunge, Antwerp, Belgium. .; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. .
Pokaż więcej
Corporate Authors:
BELNEU Consortium
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2020 Sep 11; Vol. 12 (1), pp. 108. Date of Electronic Publication: 2020 Sep 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/genetics
Amyloid beta-Protein Precursor*/genetics
Amyloid beta-Peptides ; Heterozygote ; Humans ; Mutation/genetics ; Presenilin-1/genetics ; Presenilin-2/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network.
Autorzy:
Martins S; Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich-Heine University, 40225 Düsseldorf, Germany.
Müller-Schiffmann A; Department of Neuropathology, Heinrich-Heine University, 40225 Düsseldorf, Germany.
Erichsen L; Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich-Heine University, 40225 Düsseldorf, Germany.
Bohndorf M; Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich-Heine University, 40225 Düsseldorf, Germany.
Wruck W; Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich-Heine University, 40225 Düsseldorf, Germany.
Sleegers K; Neurodegenerative Brain Diseases Group, VIB-Center for Molecular Neurology, University of Antwerp, 20610 Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, 20610 Antwerp, Belgium.
Van Broeckhoven C; Neurodegenerative Brain Diseases Group, VIB-Center for Molecular Neurology, University of Antwerp, 20610 Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, 20610 Antwerp, Belgium.
Korth C; Department of Neuropathology, Heinrich-Heine University, 40225 Düsseldorf, Germany.
Adjaye J; Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich-Heine University, 40225 Düsseldorf, Germany.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Jun 25; Vol. 21 (12). Date of Electronic Publication: 2020 Jun 25.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease/*genetics
Membrane Glycoproteins/*genetics
Receptors, Immunologic/*genetics
Aged ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Brain/metabolism ; Cell Differentiation/genetics ; Endoplasmic Reticulum/genetics ; Endoplasmic Reticulum/metabolism ; Female ; Gene Regulatory Networks/genetics ; Genetic Predisposition to Disease/genetics ; Genetic Variation/genetics ; Humans ; Male ; Membrane Glycoproteins/metabolism ; Models, Biological ; Mutation/genetics ; Myeloid Cells/metabolism ; Neurons/metabolism ; Pluripotent Stem Cells/metabolism ; Pluripotent Stem Cells/physiology ; Receptors, Immunologic/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics.
Autorzy:
Bos I; Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands. .; Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Universiteitssingel 40, Box 34, P.O. Box 616, 6200, MD, Maastricht, the Netherlands. .
Vos S; Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands.
Vandenberghe R; University Hospital Leuven, Leuven, Belgium.; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium.
Scheltens P; Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, the Netherlands.
Engelborghs S; Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium.; University of Antwerp, Antwerp, Belgium.
Frisoni G; University of Geneva, Geneva, Switzerland.; IRCCS Instituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Molinuevo JL; Alzheimer's Disease & Other Cognitive Disorders Unit, Hospital Clínic-IDIBAPS, Barcelona, Spain.; Barcelona Beta Brain Research Center, Fundació Pasqual Maragall, Barcelona, Spain.
Wallin A; Institute of Neuroscience and Physiology, Moelndal, Sweden.
Lleó A; Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Popp J; Geriatric Psychiatry, Department of Mental Health and Psychiatry, Geneva University Hospitals, Geneva, Switzerland.; Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.
Martinez-Lage P; Center for Research and Advanced Therapies, CITA-Alzheimer Foundation, San Sebastian, Spain.
Baird A; University of Oxford, Oxford, UK.
Dobson R; King's College London, London, UK.; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London, UK.; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, London, UK.; NIHR University College London Hospitals Biomedical Research Centre, London, UK.
Legido-Quigley C; King's College London, London, UK.
Sleegers K; Neurodegenerative Brain Diseases Group, VIB-Department of Molecular Genetics, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Van Broeckhoven C; Neurodegenerative Brain Diseases Group, VIB-Department of Molecular Genetics, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Bertram L; Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany.; School of Public Health, Imperial College London, London, UK.; Department of Psychology, University of Oslo, Oslo, Norway.
Ten Kate M; Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, the Netherlands.
Barkhof F; Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands.
Zetterberg H; Department of Psychiatry and Neurochemistry, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.; UK Dementia Research Institute, London, UK.
Lovestone S; University of Oxford, Oxford, UK.
Streffer J; Experimental Medicine, Janssen Pharmaceutical Companies, Beerse, Belgium.
Visser PJ; Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands.; Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, the Netherlands.
Pokaż więcej
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2018 Jul 06; Vol. 10 (1), pp. 64. Date of Electronic Publication: 2018 Jul 06.
Typ publikacji:
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Research Design*
Alzheimer Disease/*blood
Biomarkers/*blood
Biomedical Research/*methods
Aged ; Aged, 80 and over ; Alzheimer Disease/diagnosis ; Amyloid beta-Peptides/blood ; Chitinase-3-Like Protein 1/blood ; Cognitive Dysfunction ; Cohort Studies ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neurofilament Proteins/blood ; Neurogranin/blood ; Neuropsychological Tests ; Psychiatric Status Rating Scales
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification and description of three families with familial Alzheimer disease that segregate variants in the SORL1 gene.
Autorzy:
Thonberg H; Department NVS, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden. .; Department of Geriatric Medicine, Genetics unit, Karolinska University Hospital, Stockholm, Sweden. .
Chiang HH; Department NVS, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden.; Department of Geriatric Medicine, Genetics unit, Karolinska University Hospital, Stockholm, Sweden.
Lilius L; Department NVS, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden.; Department of Geriatric Medicine, Genetics unit, Karolinska University Hospital, Stockholm, Sweden.
Forsell C; Department NVS, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden.; Department of Geriatric Medicine, Genetics unit, Karolinska University Hospital, Stockholm, Sweden.
Lindström AK; Department NVS, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden.; Department of Geriatric Medicine, Genetics unit, Karolinska University Hospital, Stockholm, Sweden.
Johansson C; Department NVS, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden.; Department of Geriatric Medicine, Genetics unit, Karolinska University Hospital, Stockholm, Sweden.
Björkström J; Department NVS, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden.; Department of Geriatric Medicine, Genetics unit, Karolinska University Hospital, Stockholm, Sweden.
Thordardottir S; Department NVS, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden.; Department of Geriatric Medicine, Genetics unit, Karolinska University Hospital, Stockholm, Sweden.
Sleegers K; Neurodegenerative Brain Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Van Broeckhoven C; Neurodegenerative Brain Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Rönnbäck A; Department NVS, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden.; Department of Geriatric Medicine, Genetics unit, Karolinska University Hospital, Stockholm, Sweden.
Graff C; Department NVS, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden. .; Department of Geriatric Medicine, Genetics unit, Karolinska University Hospital, Stockholm, Sweden. .
Pokaż więcej
Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2017 Jun 09; Vol. 5 (1), pp. 43. Date of Electronic Publication: 2017 Jun 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Predisposition to Disease*
Genetic Variation*
Alzheimer Disease/*genetics
LDL-Receptor Related Proteins/*genetics
Membrane Transport Proteins/*genetics
Aged ; Aged, 80 and over ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Protein Precursor/metabolism ; Brain/metabolism ; Brain/pathology ; Case-Control Studies ; Cohort Studies ; Family ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Exome Sequencing
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations.
Autorzy:
Bettens K; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. .; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .
Vermeulen S; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. .; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .
Van Cauwenberghe C; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. .; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .
Heeman B; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. .; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .
Asselbergh B; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. .; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .
Robberecht C; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. .; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .
Engelborghs S; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .; Department of Neurology and Memory Clinic, Hospital Network Antwerp Middelheim and Hoge Beuken, Antwerp, Belgium. .
Vandenbulcke M; Department of Psychiatry and Memory Clinic, University of Leuven and University Hospitals Leuven Gasthuisberg, Leuven, Belgium. .
Vandenberghe R; Laboratory for Cognitive Neurology, Department of Neurology, University of Leuven and University Hospitals Leuven Gasthuisberg, Leuven, Belgium. .
De Deyn PP; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .; Department of Neurology and Memory Clinic, Hospital Network Antwerp Middelheim and Hoge Beuken, Antwerp, Belgium. .; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands. .
Cruts M; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. .; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .
Van Broeckhoven C; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. .; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .
Sleegers K; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. kristel.sleegers@molgen.vib-ua.be.; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. kristel.sleegers@molgen.vib-ua.be.
Pokaż więcej
Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2015 Jul 16; Vol. 10, pp. 30. Date of Electronic Publication: 2015 Jul 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutation, Missense*
Alzheimer Disease/*genetics
Clusterin/*metabolism
Aged ; Aged, 80 and over ; Alzheimer Disease/epidemiology ; Alzheimer Disease/physiopathology ; Amino Acid Substitution ; Belgium/epidemiology ; Biological Transport ; Clusterin/genetics ; Cystine/chemistry ; Dimerization ; Endoplasmic Reticulum/metabolism ; Exons/genetics ; Female ; Frameshift Mutation ; Golgi Apparatus/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; Male ; Protein Conformation ; Recombinant Fusion Proteins/metabolism ; Transduction, Genetic ; Transfection
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.
Autorzy:
Escott-Price V; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Bellenguez C; Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France.
Wang LS; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
Choi SH; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Harold D; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Jones L; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Holmans P; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Gerrish A; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Vedernikov A; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Richards A; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
DeStefano AL; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Lambert JC; Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France.
Ibrahim-Verbaas CA; Department of Epidemiology and Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Naj AC; Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Sims R; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Jun G; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America.
Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Beecham GW; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America.
Grenier-Boley B; Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France.
Russo G; Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland.
Thornton-Wells TA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America.
Denning N; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Smith AV; University of Iceland, Faculty of Medicine, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland.
Chouraki V; Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America.
Thomas C; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Ikram MA; Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.
Zelenika D; Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France.
Vardarajan BN; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America; Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America.
Kamatani Y; Fondation Jean Dausset- CEPH, Paris, France.
Lin CF; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
Schmidt H; Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Kunkle B; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America.
Dunstan ML; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Vronskaya M; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Johnson AD; NHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, Framingham, Massachusetts, United States of America.
Ruiz A; Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain.
Bihoreau MT; Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France.
Reitz C; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America; Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America.
Pasquier F; Université Lille 2, Lille, France; CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France.
Hollingworth P; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Hanon O; University Paris Descartes, Sorbonne Paris V, Broca Hospital, Geriatrics department, Paris, France.
Fitzpatrick AL; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America; Departments of Epidemiology and Global Health, University of Washington, Seattle, Washington, United States of America.
Buxbaum JD; Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America; Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America; Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America.
Campion D; CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France.
Crane PK; Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Baldwin C; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America.
Becker T; German Center for Neurodegenerative Diseases (DZNE), Bonn, and Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.
Gudnason V; University of Iceland, Faculty of Medicine, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland.
Cruchaga C; Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Craig D; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
Amin N; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Berr C; INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France.
Lopez OL; Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
De Jager PL; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Boston, Massachusetts, United States of America.
Deramecourt V; Université Lille 2, Lille, France; CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France.
Johnston JA; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
Evans D; Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of America.
Lovestone S; King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom.
Letenneur L; Inserm U897, Victor Segalen University, F-33076, Bordeaux, France.
Hernández I; Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain.
Rubinsztein DC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Eiriksdottir G; Icelandic Heart Association, Kopavogur, Iceland.
Sleegers K; Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Goate AM; Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Fiévet N; Inserm U744, Lille, France; Institut Pasteur de Lille, Lille, France.
Huentelman MJ; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America.
Gill M; Discipline of Psychiatry, Trinity College, Dublin, Ireland.
Brown K; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
Kamboh MI; Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Keller L; Aging Reasearch Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Barberger-Gateau P; King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom.
McGuinness B; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
Larson EB; Department of Medicine, University of Washington, Seattle, Washington, United States of America; Group Health Research Institute, Group Health, Seattle, Washington, United States of America.
Myers AJ; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.
Dufouil C; Inserm U897, Victor Segalen University, F-33076, Bordeaux, France.
Todd S; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
Wallon D; CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France.
Love S; University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, United Kingdom.
Rogaeva E; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.
Gallacher J; Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom.
George-Hyslop PS; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada; Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Clarimon J; Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain; Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.
Lleo A; Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain; Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.
Bayer A; Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom.
Tsuang DW; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States of America.
Yu L; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America.
Tsolaki M; 3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Bossù P; Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy.
Spalletta G; Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy.
Proitsi P; King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom.
Collinge J; MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.
Sorbi S; NEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy; Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy.
Garcia FS; Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain.
Fox NC; Dementia Research Center, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.
Hardy J; Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, United Kingdom.
Naranjo MC; Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain.
Bosco P; IRCCS Associazione Oasi Maria SS, Troina, Italy.
Clarke R; Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom.
Brayne C; Cognitive Function and Ageing Study (CFAS), Institute of Public Health, University of Cambridge, Cambridge, United Kingdom.
Galimberti D; University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy.
Scarpini E; University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy.
Bonuccelli U; Neurological Clinic, University of Pisa, Pisa, Italy.
Mancuso M; Neurological Clinic, University of Pisa, Pisa, Italy.
Siciliano G; Neurological Clinic, University of Pisa, Pisa, Italy.
Moebus S; Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Mecocci P; Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.
Zompo MD; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Maier W; Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany.
Hampel H; Department of Psychiatry, University of Frankfurt am Main, Frankfurt am Main, Germany (H.H.); Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany.
Pilotto A; Gerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
Frank-García A; Centro de Biología Molecular Severo Ochoa (CSIC-UAM); Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Instituto de Investigación Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain.
Panza F; Department of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy.
Solfrizzi V; Department of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy.
Caffarra P; Department of Neuroscience-University of Parma, Parma, Italy; Center for Cognitive Disorders AUSL, Parma, Italy.
Nacmias B; NEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy; Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy.
Perry W; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America.
Mayhaus M; Department Of Psychiatry, University Hospital, Saarland, Germany.
Lannfelt L; Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Pichler S; Department Of Psychiatry, University Hospital, Saarland, Germany.
Carrasquillo MM; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.
Ingelsson M; Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
Beekly D; National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, United States of America.
Alvarez V; Genetica molecular-Huca-Oviedo, Oviedo, Spain.
Zou F; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.
Valladares O; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
Younkin SG; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.
Coto E; Genetica molecular-Huca-Oviedo, Oviedo, Spain.
Hamilton-Nelson KL; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America.
Gu W; Department of Psychiatry, University Hospital, Saarland, Germany.
Razquin C; Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain.
Pastor P; Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain; CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.
Mateo I; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IFIMAV), Santander, Spain.
Owen MJ; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Faber KM; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America.
Jonsson PV; University of Iceland, Faculty of Medicine, Reykjavik, Iceland; Landspitali University Hospital, Reykjavik, Iceland.
Combarros O; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IFIMAV), Santander, Spain.
O'Donovan MC; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Cantwell LB; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
Soininen H; Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
Blacker D; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America; Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, United States of America.
Mead S; MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.
Mosley TH Jr; Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
Bennett DA; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America.
Harris TB; Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America.
Fratiglioni L; Aging Research Center, Department Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Holmes C; Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, United Kingdom.
de Bruijn RF; Departments of Neurology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Passmore P; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
Montine TJ; Department of Pathology, University of Washington, Seattle, Washington, United States of America.
Bettens K; Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America.
Brice A; INSERM UMR_S975-CNRS UMR 7225, Université Pierre et Marie Curie, Centre de recherche de l'Institut du Cerveau et de la Moëlle épinière-CRICM, Hôpital de la Salpêtrière, Paris France; AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France.
Morgan K; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
Foroud TM; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America.
Kukull WA; Department of Epidemiology, University of Washington, Seattle, Washington, United States of America.
Hannequin D; CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France.
Powell JF; King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom.
Nalls MA; Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America.
Ritchie K; INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France; Imperial College, London, United Kingdom.
Lunetta KL; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Kauwe JS; Department of Biology, Brigham Young University, Provo, Utah, United States of America.
Boerwinkle E; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America; Human Genetics Center and Div. of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, Texas, United States of America.
Riemenschneider M; Department of Psychiatry, University Hospital, Saarland, Germany.
Boada M; Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain; Hospital Universitari Vall d'Hebron - Institut de Recerca, Universitat Autònoma de Barcelona. (VHIR-UAB), Barcelona, Spain.
Hiltunen M; Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
Martin ER; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America.
Schmidt R; Department of Neurology, Medical University Graz, Graz, Austria.
Rujescu D; Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany.
Dartigues JF; Inserm U897, Victor Segalen University, F-33076, Bordeaux, France; Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France.
Mayeux R; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America; Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America.
Tzourio C; Inserm U708, Victor Segalen University, Bordeaux, France.
Hofman A; Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.
Nöthen MM; Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany.
Graff C; Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden; Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KIADRC, Stockholm, Sweden.
Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America; Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America.
Haines JL; Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America.
Lathrop M; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America; Fondation Jean Dausset- CEPH, Paris, France; McGill University and Génome Québec Innovation Centre, Montreal, Canada.
Pericak-Vance MA; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America.
Launer LJ; Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America.
Van Broeckhoven C; Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Farrer LA; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America.
van Duijn CM; Netherlands Consortium for Healthy Aging, Leiden, The Netherlands; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Center for Medical Systems Biology, Leiden, The Netherlands.
Ramirez A; Department of Psychiatry and Psychotherapy and Institute of Human Genetics, University of Bonn, Bonn, Germany.
Seshadri S; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America; The Framingham Heart Study, Framingham, Massachusetts, United States of America.
Schellenberg GD; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
Amouyel P; Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France; CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France; Centre Hospitalier Régional Universitaire de Lille, Lille, France.
Williams J; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Pokaż więcej
Corporate Authors:
United Kingdom Brain Expression Consortium
Cardiovascular Health Study (CHS)
Źródło:
PloS one [PLoS One] 2014 Jun 12; Vol. 9 (6), pp. e94661. Date of Electronic Publication: 2014 Jun 12 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Alzheimer Disease/*genetics
Carrier Proteins/*genetics
Heat-Shock Proteins/*genetics
Case-Control Studies ; Genome-Wide Association Study ; Humans ; Polymorphism, Single Nucleotide ; Receptors, Antigen, B-Cell/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
Autorzy:
Lambert JC
Ibrahim-Verbaas CA
Harold D
Naj AC
Sims R
Bellenguez C
DeStafano AL
Bis JC
Beecham GW
Grenier-Boley B
Russo G
Thorton-Wells TA
Jones N
Smith AV
Chouraki V
Thomas C
Ikram MA
Zelenika D
Vardarajan BN
Kamatani Y
Lin CF
Gerrish A
Schmidt H
Kunkle B
Dunstan ML
Ruiz A
Bihoreau MT
Choi SH
Reitz C
Pasquier F
Cruchaga C
Craig D
Amin N
Berr C
Lopez OL
De Jager PL
Deramecourt V
Johnston JA
Evans D
Lovestone S
Letenneur L
Morón FJ
Rubinsztein DC
Eiriksdottir G
Sleegers K
Goate AM
Fiévet N
Huentelman MW
Gill M
Brown K
Kamboh MI
Keller L
Barberger-Gateau P
McGuiness B
Larson EB
Green R
Myers AJ
Dufouil C
Todd S
Wallon D
Love S
Rogaeva E
Gallacher J
St George-Hyslop P
Clarimon J
Lleo A
Bayer A
Tsuang DW
Yu L
Tsolaki M
Bossù P
Spalletta G
Proitsi P
Collinge J
Sorbi S
Sanchez-Garcia F
Fox NC
Hardy J
Deniz Naranjo MC
Bosco P
Clarke R
Brayne C
Galimberti D
Mancuso M
Matthews F
Moebus S
Mecocci P
Del Zompo M
Maier W
Hampel H
Pilotto A
Bullido M
Panza F
Caffarra P
Nacmias B
Gilbert JR
Mayhaus M
Lannefelt L
Hakonarson H
Pichler S
Carrasquillo MM
Ingelsson M
Beekly D
Alvarez V
Zou F
Valladares O
Younkin SG
Coto E
Hamilton-Nelson KL
Gu W
Razquin C
Pastor P
Mateo I
Owen MJ
Faber KM
Jonsson PV
Combarros O
O'Donovan MC
Cantwell LB
Soininen H
Blacker D
Mead S
Mosley TH Jr
Bennett DA
Harris TB
Fratiglioni L
Holmes C
de Bruijn RF
Passmore P
Montine TJ
Bettens K
Rotter JI
Brice A
Morgan K
Foroud TM
Kukull WA
Hannequin D
Powell JF
Nalls MA
Ritchie K
Lunetta KL
Kauwe JS
Boerwinkle E
Riemenschneider M
Boada M
Hiltuenen M
Martin ER
Schmidt R
Rujescu D
Wang LS
Dartigues JF
Mayeux R
Tzourio C
Hofman A
Nöthen MM
Graff C
Psaty BM
Jones L
Haines JL
Holmans PA
Lathrop M
Pericak-Vance MA
Launer LJ
Farrer LA
van Duijn CM
Van Broeckhoven C
Moskvina V
Seshadri S
Williams J
Schellenberg GD
Amouyel P
Pokaż więcej
Corporate Authors:
European Alzheimer's Disease Initiative (EADI)
Genetic and Environmental Risk in Alzheimer's Disease
Alzheimer's Disease Genetic Consortium
Cohorts for Heart and Aging Research in Genomic Epidemiology
Źródło:
Nature genetics [Nat Genet] 2013 Dec; Vol. 45 (12), pp. 1452-8. Date of Electronic Publication: 2013 Oct 27.
Typ publikacji:
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Loci*
Genetic Predisposition to Disease*
Alzheimer Disease/*genetics
Genome-Wide Association Study/*statistics & numerical data
Age of Onset ; Aged ; Aged, 80 and over ; Alzheimer Disease/epidemiology ; Case-Control Studies ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.
Autorzy:
Chapuis J; 1] INSERM U744, Université Lille Nord de France, Institut pasteur de Lille, Lille, France [2] Université Lille Nord de France, Institut pasteur de Lille, Lille, France [3] Université Lille-Nord de France, Institut pasteur de Lille, Lille, France.
Hansmannel F
Gistelinck M
Mounier A
Van Cauwenberghe C
Kolen KV
Geller F
Sottejeau Y
Harold D
Dourlen P
Grenier-Boley B
Kamatani Y
Delepine B
Demiautte F
Zelenika D
Zommer N
Hamdane M
Bellenguez C
Dartigues JF
Hauw JJ
Letronne F
Ayral AM
Sleegers K
Schellens A
Broeck LV
Engelborghs S
De Deyn PP
Vandenberghe R
O'Donovan M
Owen M
Epelbaum J
Mercken M
Karran E
Bantscheff M
Drewes G
Joberty G
Campion D
Octave JN
Berr C
Lathrop M
Callaerts P
Mann D
Williams J
Buée L
Dewachter I
Van Broeckhoven C
Amouyel P
Moechars D
Dermaut B
Lambert JC
Pokaż więcej
Corporate Authors:
GERAD consortium
Źródło:
Molecular psychiatry [Mol Psychiatry] 2013 Nov; Vol. 18 (11), pp. 1225-34. Date of Electronic Publication: 2013 Feb 12.
Typ publikacji:
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Adaptor Proteins, Signal Transducing/*genetics
Alzheimer Disease/*genetics
Alzheimer Disease/*pathology
Genetic Predisposition to Disease/*genetics
Nuclear Proteins/*genetics
Tumor Suppressor Proteins/*genetics
tau Proteins/*metabolism
Adaptor Proteins, Signal Transducing/biosynthesis ; Alzheimer Disease/metabolism ; Animals ; Brain/metabolism ; Brain/pathology ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Case-Control Studies ; Cells, Cultured ; Drosophila Proteins/deficiency ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Endophenotypes ; Gene Expression/genetics ; Humans ; Mice ; Nerve Degeneration/genetics ; Nerve Degeneration/pathology ; Nuclear Proteins/biosynthesis ; Plaque, Amyloid/pathology ; Polymorphism, Single Nucleotide/genetics ; Synaptosomes/pathology ; Transcription Factors/deficiency ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Tumor Suppressor Proteins/biosynthesis ; tau Proteins/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.
Autorzy:
Lambert JC; INSERM, U744, Lille, France. />Grenier-Boley B
Harold D
Zelenika D
Chouraki V
Kamatani Y
Sleegers K
Ikram MA
Hiltunen M
Reitz C
Mateo I
Feulner T
Bullido M
Galimberti D
Concari L
Alvarez V
Sims R
Gerrish A
Chapman J
Deniz-Naranjo C
Solfrizzi V
Sorbi S
Arosio B
Spalletta G
Siciliano G
Epelbaum J
Hannequin D
Dartigues JF
Tzourio C
Berr C
Schrijvers EM
Rogers R
Tosto G
Pasquier F
Bettens K
Van Cauwenberghe C
Fratiglioni L
Graff C
Delepine M
Ferri R
Reynolds CA
Lannfelt L
Ingelsson M
Prince JA
Chillotti C
Pilotto A
Seripa D
Boland A
Mancuso M
Bossù P
Annoni G
Nacmias B
Bosco P
Panza F
Sanchez-Garcia F
Del Zompo M
Coto E
Owen M
O'Donovan M
Valdivieso F
Caffarra P
Scarpini E
Combarros O
Buée L
Campion D
Soininen H
Breteler M
Riemenschneider M
Van Broeckhoven C
Alpérovitch A
Lathrop M
Trégouët DA
Williams J
Amouyel P
Pokaż więcej
Źródło:
Molecular psychiatry [Mol Psychiatry] 2013 Apr; Vol. 18 (4), pp. 461-70. Date of Electronic Publication: 2012 Mar 20.
Typ publikacji:
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genome-Wide Association Study*
Adaptor Proteins, Signal Transducing/*genetics
Alzheimer Disease/*genetics
Genetic Predisposition to Disease/*genetics
Haplotypes/*genetics
Alzheimer Disease/blood ; Amyloid beta-Peptides/blood ; Case-Control Studies ; Humans ; Polymorphism, Single Nucleotide/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites.
Autorzy:
Brouwers N; Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium.
Van Cauwenberghe C
Engelborghs S
Lambert JC
Bettens K
Le Bastard N
Pasquier F
Montoya AG
Peeters K
Mattheijssens M
Vandenberghe R
Deyn PP
Cruts M
Amouyel P
Sleegers K
Van Broeckhoven C
Pokaż więcej
Źródło:
Molecular psychiatry [Mol Psychiatry] 2012 Feb; Vol. 17 (2), pp. 223-33. Date of Electronic Publication: 2011 Mar 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease/*genetics
Complement Factor I/*metabolism
DNA Copy Number Variations/*genetics
Polymorphism, Single Nucleotide/*genetics
Receptors, Complement/*genetics
Aged ; Aged, 80 and over ; Alzheimer Disease/cerebrospinal fluid ; Amyloid beta-Peptides/cerebrospinal fluid ; Apolipoprotein E4/genetics ; Cohort Studies ; Female ; Gene Frequency ; Genome-Wide Association Study ; Genotype ; Humans ; Logistic Models ; Male ; Meta-Analysis as Topic ; Odds Ratio ; Peptide Fragments/cerebrospinal fluid ; Segmental Duplications, Genomic ; tau Proteins/cerebrospinal fluid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk.
Autorzy:
Bettens K; Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, 2610 Antwerpen, Belgium. kristel.sleegers@molgen.vib-ua.be.
Brouwers N
Engelborghs S
Lambert JC
Rogaeva E
Vandenberghe R
Le Bastard N
Pasquier F
Vermeulen S
Van Dongen J
Mattheijssens M
Peeters K
Mayeux R
St George-Hyslop P
Amouyel P
De Deyn PP
Sleegers K
Van Broeckhoven C
Pokaż więcej
Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2012 Jan 16; Vol. 7, pp. 3. Date of Electronic Publication: 2012 Jan 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Variation*
Alzheimer Disease/*genetics
Clusterin/*genetics
Aged ; Aged, 80 and over ; Alleles ; Canada ; Chromosome Mapping ; Cohort Studies ; Exons ; Female ; Gene Frequency ; Genome-Wide Association Study ; Genotype ; Humans ; Male ; Middle Aged ; Mutagenesis, Insertional ; Polymorphism, Single Nucleotide ; Risk Factors ; Sequence Deletion ; White People/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects.
Autorzy:
Wikgren M; Division of Psychiatry, Department of Clinical Sciences, Umeå University, Umeå, Sweden. />Karlsson T
Lind J
Nilbrink T
Hultdin J
Sleegers K
Van Broeckhoven C
Roos G
Nilsson LG
Nyberg L
Adolfsson R
Norrback KF
Pokaż więcej
Źródło:
PloS one [PLoS One] 2012; Vol. 7 (4), pp. e34292. Date of Electronic Publication: 2012 Apr 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apolipoprotein E3/*genetics
Hippocampus/*physiology
Leukocytes/*physiology
Telomere/*genetics
Age Factors ; Aged ; Alleles ; Apolipoprotein E4/genetics ; Atrophy/genetics ; Atrophy/pathology ; Biomarkers/metabolism ; Cell Proliferation ; Cognition ; Female ; Hippocampus/pathology ; Humans ; Leukocytes/ultrastructure ; Male ; Memory, Episodic ; Middle Aged ; Neurogenesis/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 31

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies