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    Tytuł:
    Antibodies as drugs-a Keystone Symposia report.
    Autorzy:
    Cable J; PhD Science Writer, New York, New York, USA.
    Saphire EO; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.; Department of Medicine, University of California San Diego, La Jolla, California, USA.
    Hayday AC; Peter Gorer Department of Immunobiology, King's College London, London, UK.; Cancer Research UK Cancer Immunotherapy Accelerator, London, UK.; Immunosurveillance Laboratory, The Francis Crick Institute, London, UK.
    Wiltshire TD; Mayo Clinic, Rochester, Minnesota, USA.
    Mousa JJ; Department of Infectious Diseases and Center for Vaccines and Immunology, College of Veterinary Medicine, Athens, Georgia, USA.; Department of Biochemistry and Molecular Biology, Franklin College of Arts and Sciences, University of Georgia, Athens, Georgia, USA.; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
    Humphreys DP; Protein Sciences, UCB Pharma, Berkshire, UK.
    Breij ECW; Translational Research and Precision Medicine, Genmab BV, Utrecht, the Netherlands.
    Bruhns P; Institut Pasteur, Université de Paris, Unit of Antibodies in Therapy and Pathology, Paris, France.
    Broketa M; Institut Pasteur, Université de Paris, Unit of Antibodies in Therapy and Pathology, Paris, France.
    Furuya G; Department of Preventive Medicine and Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
    Hauser BM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.
    Mahévas M; Service de Médecine Interne, Centre de Référence des Cytopénies Auto-immunes de l'adulte, Centre Hospitalier Universitaire Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Université Paris-Est Créteil, Créteil, France.
    Carfi A; Moderna Inc., Cambridge, Massachusetts, USA.; Department of Pathology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
    Cantaert T; Immunology Unit, Institut Pasteur du Cambodge, The Pasteur Network, Phnom Penh, Cambodia.
    Kwong PD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
    Tripathi P; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
    Davis JH; Invenra, Inc, Madison, Wisconsin, USA.
    Brewis N; F-star Therapeutics Ltd., Cambridge, UK.
    Keyt BA; IGM Biosciences, Inc., Mountainview, California, USA.
    Fennemann FL; Lava Therapeutics, Utrecht, the Netherlands.
    Dussupt V; Emerging Infectious Diseases Branch, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
    Sivasubramanian A; Computational Biology, Adimab, Palo Alto, California, USA.
    Kim PM; Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, Canada.; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.
    Rawi R; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
    Richardson E; Department of Statistics, University of Oxford, Oxford, UK.
    Leventhal D; Generate Biomedicines, Somerville, Massachusetts, USA.
    Wolters RM; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
    Geuijen CAW; Merus N.V., Utrecht, the Netherlands.
    Sleeman MA; Regeneron Pharmaceuticals, Tarrytown, New York, USA.
    Pengo N; Mabylon AG, Schlieren, Switzerland.
    Donnellan FR; University of Oxford, Oxford, UK.
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    Źródło:
    Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2023 Jan; Vol. 1519 (1), pp. 153-166. Date of Electronic Publication: 2022 Nov 16.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antibodies, Bispecific*/therapeutic use
    Humans ; Immunotherapy
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes.
    Autorzy:
    Panea C; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA. .
    Zhang R; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
    VanValkenburgh J; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
    Ni M; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
    Adler C; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
    Wei Y; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
    Ochoa F; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
    Schmahl J; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
    Tang Y; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
    Siao CJ; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
    Poueymirou W; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
    Espert J; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
    Lim WK; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
    Atwal GS; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
    Murphy AJ; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
    Sleeman MA; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
    Hovhannisyan Z; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
    Haxhinasto S; Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA. .
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    Źródło:
    Communications biology [Commun Biol] 2021 Jul 26; Vol. 4 (1), pp. 913. Date of Electronic Publication: 2021 Jul 26.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Butyrophilins/*genetics
    Ileum/*immunology
    Immunity, Innate/*genetics
    Immunity, Mucosal/*genetics
    Intraepithelial Lymphocytes/*metabolism
    Animals ; Butyrophilins/metabolism ; Female ; Mice ; Mice, Inbred C57BL
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Absence of central tolerance in Aire-deficient mice synergizes with immune-checkpoint inhibition to enhance antitumor responses.
    Autorzy:
    Benitez AA; Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
    Khalil-Agüero S; Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
    Nandakumar A; Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
    Gupta NT; Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
    Zhang W; Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
    Atwal GS; Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
    Murphy AJ; Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
    Sleeman MA; Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
    Haxhinasto S; Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA. .
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    Źródło:
    Communications biology [Commun Biol] 2020 Jul 08; Vol. 3 (1), pp. 355. Date of Electronic Publication: 2020 Jul 08.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Immune Checkpoint Inhibitors/*immunology
    Immune Tolerance/*immunology
    Neoplasms, Experimental/*immunology
    Polyendocrinopathies, Autoimmune/*immunology
    Transcription Factors/*deficiency
    Animals ; CD8-Positive T-Lymphocytes/immunology ; Melanoma, Experimental/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neoplasm Transplantation ; T-Lymphocytes/immunology ; Tumor Escape/immunology ; AIRE Protein
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1.
    Autorzy:
    Vousden KA; MedImmune Ltd, Cambridge, CB21 6GH, UK. .
    Lundqvist T; AstraZeneca AB R&D, Pepparedsleden 1, 431 50, Mölndal, Sweden.
    Popovic B; MedImmune Ltd, Cambridge, CB21 6GH, UK.
    Naiman B; MedImmune LLC, One MedImmune Way, Gaithersburg, MD, 20878, USA.
    Carruthers AM; MedImmune Ltd, Cambridge, CB21 6GH, UK.
    Newton P; MedImmune Ltd, Cambridge, CB21 6GH, UK.
    Johnson DJD; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK.
    Pomowski A; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK.
    Wilkinson T; MedImmune Ltd, Cambridge, CB21 6GH, UK.
    Dufner P; MedImmune Ltd, Cambridge, CB21 6GH, UK.
    de Mendez I; MedImmune Ltd, Cambridge, CB21 6GH, UK.
    Mallinder PR; MedImmune Ltd, Cambridge, CB21 6GH, UK.
    Murray C; AstraZeneca R&D, Alderley Park, Macclesfield, Cheshire, SK10 4TF, UK.
    Strain M; MedImmune Ltd, Cambridge, CB21 6GH, UK.
    Connor J; MedImmune LLC, One MedImmune Way, Gaithersburg, MD, 20878, USA.
    Murray LA; MedImmune Ltd, Cambridge, CB21 6GH, UK.
    Sleeman MA; MedImmune Ltd, Cambridge, CB21 6GH, UK.
    Lowe DC; MedImmune Ltd, Cambridge, CB21 6GH, UK.
    Huntington JA; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK.
    Vaughan TJ; MedImmune Ltd, Cambridge, CB21 6GH, UK.
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    Źródło:
    Scientific reports [Sci Rep] 2019 Feb 07; Vol. 9 (1), pp. 1605. Date of Electronic Publication: 2019 Feb 07.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antibodies, Neutralizing/*immunology
    Plasminogen Activator Inhibitor 1/*immunology
    Amino Acid Sequence ; Animals ; Antibodies, Neutralizing/chemistry ; Antibody Specificity ; Humans ; Mice ; Models, Molecular ; Plasminogen Activator Inhibitor 1/chemistry ; Protein Conformation ; Rats
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD.
    Autorzy:
    Briend E; MedImmune Ltd, Granta Park, Cambridge, CB21 6GH, UK.; Present address: Agenus Ltd, Cambridge, UK.
    Ferguson GJ; MedImmune Ltd, Granta Park, Cambridge, CB21 6GH, UK.
    Mori M; Department of Experimental Medical Science, BMC D12, Lund University, SE-221 84, Lund, Sweden.
    Damera G; MedImmune LLC, 1 MedImmune Way, Gaithersburg, MD, USA.
    Stephenson K; MedImmune Ltd, Granta Park, Cambridge, CB21 6GH, UK.; Present address: University of Nottingham, Nottingham, UK.
    Karp NA; Quantitative Biology IMED, AstraZeneca R&D, Cambridge, UK.
    Sethi S; Department of Medicine, University at Buffalo, 3495 Bailey Avenue, Buffalo, NY, 14215, USA.
    Ward CK; MedImmune LLC, 1 MedImmune Way, Gaithersburg, MD, USA.; Present address: Bristol-Myers Squibb, Princeton, NJ, USA.
    Sleeman MA; MedImmune Ltd, Granta Park, Cambridge, CB21 6GH, UK.; Present address: Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
    Erjefält JS; Department of Experimental Medical Science, BMC D12, Lund University, SE-221 84, Lund, Sweden.; Department of Respiratory Medicine and Allergology, Lund University Hospital, Lund, Sweden.
    Finch DK; MedImmune Ltd, Granta Park, Cambridge, CB21 6GH, UK. .
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    Źródło:
    Respiratory research [Respir Res] 2017 Aug 22; Vol. 18 (1), pp. 159. Date of Electronic Publication: 2017 Aug 22.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Severity of Illness Index*
    Interferon-gamma/*biosynthesis
    Interleukin-18/*biosynthesis
    Lung/*metabolism
    Lymphocytes/*metabolism
    Pulmonary Disease, Chronic Obstructive/*metabolism
    Humans ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/pathology ; Longitudinal Studies ; Lung/pathology ; Lymphocytes/pathology ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/pathology ; Sputum/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium.
    Autorzy:
    Murray LA; Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Granta Park, Cambridge, CB21 6GH, United Kingdom. .
    Dunmore R; Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Granta Park, Cambridge, CB21 6GH, United Kingdom.
    Camelo A; Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Granta Park, Cambridge, CB21 6GH, United Kingdom.
    Da Silva CA; Respiratory, Inflammation and Autoimmunity innovative Medicines Unit, AstraZeneca R&D, Mölndal, Sweden.
    Gustavsson MJ; Respiratory, Inflammation and Autoimmunity innovative Medicines Unit, AstraZeneca R&D, Mölndal, Sweden.
    Habiel DM; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
    Hackett TL; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.; James Hogg Research Centre, University of British Columbia, Vancouver, Canada.
    Hogaboam CM; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
    Sleeman MA; Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Granta Park, Cambridge, CB21 6GH, United Kingdom.
    Knight DA; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.; James Hogg Research Centre, University of British Columbia, Vancouver, Canada.; School of Biomedical Sciences and Pharmacy, Newcastle, Australia.; Priority Research Centre for Healthy Lungs, University of Newcastle and Hunter Medical Research Institute, New South Wales, Australia.
    Pokaż więcej
    Źródło:
    Respiratory research [Respir Res] 2017 May 03; Vol. 18 (1), pp. 82. Date of Electronic Publication: 2017 May 03.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Epithelial-Mesenchymal Transition/*drug effects
    Pulmonary Disease, Chronic Obstructive/*physiopathology
    Pulmonary Fibrosis/*chemically induced
    Respiratory Mucosa/*drug effects
    Respiratory Mucosa/*physiopathology
    Smoke/*adverse effects
    Tobacco Products/*poisoning
    Animals ; Apoptosis/drug effects ; Humans ; Mice ; Mice, Inbred C57BL ; Pulmonary Disease, Chronic Obstructive/chemically induced ; Pulmonary Disease, Chronic Obstructive/pathology ; Pulmonary Fibrosis/pathology ; Pulmonary Fibrosis/physiopathology ; Respiratory Mucosa/pathology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells.
    Autorzy:
    Piper SC; Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Cambridge, United Kingdom.
    Ferguson J
    Kay L
    Parker LC
    Sabroe I
    Sleeman MA
    Briend E
    Finch DK
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    Źródło:
    PloS one [PLoS One] 2013 May 28; Vol. 8 (5), pp. e63365. Date of Electronic Publication: 2013 May 28 (Print Publication: 2013).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antiviral Agents/*metabolism
    Bronchi/*pathology
    Epithelial Cells/*virology
    Inflammation Mediators/*metabolism
    Interleukin-1/*metabolism
    Interleukin-18/*metabolism
    Rhinovirus/*physiology
    Autocrine Communication ; Caspase 1/metabolism ; Cells, Cultured ; Enzyme Activation ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; HeLa Cells ; Humans ; Interleukin-1alpha/metabolism ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Interleukin-8/metabolism ; Picornaviridae Infections/metabolism ; Picornaviridae Infections/virology ; Signal Transduction ; Viral Load ; Virus Internalization ; Virus Replication
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Effects of CXCL13 inhibition on lymphoid follicles in models of autoimmune disease.
    Autorzy:
    Finch DK; MedImmune Ltd, Cambridge, UK. />Ettinger R
    Karnell JL
    Herbst R
    Sleeman MA
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    Źródło:
    European journal of clinical investigation [Eur J Clin Invest] 2013 May; Vol. 43 (5), pp. 501-9. Date of Electronic Publication: 2013 Mar 20.
    Typ publikacji:
    Journal Article; Review
    MeSH Terms:
    Disease Models, Animal*
    Autoimmune Diseases/*immunology
    Chemokine CXCL13/*antagonists & inhibitors
    Lymphoid Tissue/*immunology
    Animals ; Chemokine CXCL13/immunology ; Mice ; Mice, Transgenic ; Receptors, CXCR5/immunology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    An anti-human ICAM-1 antibody inhibits rhinovirus-induced exacerbations of lung inflammation.
    Autorzy:
    Traub S; National Heart and Lung Institute, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom.
    Nikonova A
    Carruthers A
    Dunmore R
    Vousden KA
    Gogsadze L
    Hao W
    Zhu Q
    Bernard K
    Zhu J
    Dymond M
    McLean GR
    Walton RP
    Glanville N
    Humbles A
    Khaitov M
    Wells T
    Kolbeck R
    Leishman AJ
    Sleeman MA
    Bartlett NW
    Johnston SL
    Pokaż więcej
    Źródło:
    PLoS pathogens [PLoS Pathog] 2013; Vol. 9 (8), pp. e1003520. Date of Electronic Publication: 2013 Aug 01.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antibodies, Monoclonal, Murine-Derived/*pharmacology
    Immunoglobulin G/*pharmacology
    Intercellular Adhesion Molecule-1/*immunology
    Picornaviridae Infections/*immunology
    Pneumonia, Viral/*immunology
    Rhinovirus/*immunology
    Virus Internalization/*drug effects
    Animals ; Antibodies, Monoclonal, Murine-Derived/immunology ; Chemokines/genetics ; Chemokines/immunology ; HeLa Cells ; Humans ; Immunoglobulin G/immunology ; Intercellular Adhesion Molecule-1/genetics ; Jurkat Cells ; Lymphocyte Function-Associated Antigen-1/genetics ; Lymphocyte Function-Associated Antigen-1/immunology ; Mice ; Mice, Transgenic ; Picornaviridae Infections/drug therapy ; Picornaviridae Infections/genetics ; Picornaviridae Infections/pathology ; Pneumonia, Viral/diet therapy ; Pneumonia, Viral/genetics ; Pneumonia, Viral/pathology ; Th2 Cells/immunology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Developing the next generation of monoclonal antibodies for the treatment of rheumatoid arthritis.
    Autorzy:
    Campbell J; Department of Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Cambridge, UK.
    Lowe D
    Sleeman MA
    Pokaż więcej
    Źródło:
    British journal of pharmacology [Br J Pharmacol] 2011 Apr; Vol. 162 (7), pp. 1470-84.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Review
    MeSH Terms:
    Antibodies, Monoclonal/*therapeutic use
    Arthritis, Rheumatoid/*therapy
    Animals ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/immunology ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/pathology ; Autoimmunity/drug effects ; Humans ; Protein Engineering ; Receptors, Pattern Recognition/immunology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-15 z 15

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