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Wyszukujesz frazę ""Smad1 Protein"" wg kryterium: Temat


Tytuł:
Mechanical force induces macrophage-derived exosomal UCHL3 promoting bone marrow mesenchymal stem cell osteogenesis by targeting SMAD1.
Autorzy:
Pu P; Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, 210000, China.; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210000, China.; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, 210000, China.; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710049, China.
Wu S; Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, 210000, China.; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210000, China.; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, 210000, China.
Zhang K; Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, 210000, China.; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210000, China.; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, 210000, China.
Xu H; Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, 210000, China.; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210000, China.; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, 210000, China.
Guan J; Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, 210000, China.; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210000, China.; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, 210000, China.
Jin Z; Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, 210000, China.; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210000, China.; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, 210000, China.
Sun W; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210000, China.
Zhang H; School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 210000, China. .; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, 210000, China. .
Yan B; Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, 210000, China. .; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210000, China. .; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, 210000, China. .
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Źródło:
Journal of nanobiotechnology [J Nanobiotechnology] 2023 Mar 14; Vol. 21 (1), pp. 88. Date of Electronic Publication: 2023 Mar 14.
Typ publikacji:
Journal Article
MeSH Terms:
Mesenchymal Stem Cells*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
Ubiquitin Thiolesterase*/metabolism
Smad1 Protein*/metabolism
Cell Differentiation/physiology ; Macrophages/metabolism ; Osteogenesis ; Proteomics
Czasopismo naukowe
Tytuł:
BMP9 promotes cutaneous wound healing by activating Smad1/5 signaling pathways and cytoskeleton remodeling.
Autorzy:
Chai P; Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Yu J; Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Wang X; Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Ge S; Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Jia R; Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2021 Jan; Vol. 11 (1), pp. e271.
Typ publikacji:
Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
Cytoskeleton/*genetics
Growth Differentiation Factor 2/*genetics
Signal Transduction/*genetics
Smad1 Protein/*genetics
Smad5 Protein/*genetics
Wound Healing/*genetics
Animals ; Cytoskeleton/metabolism ; Disease Models, Animal ; Growth Differentiation Factor 2/metabolism ; Mice ; Skin/injuries ; Skin/metabolism ; Smad1 Protein/metabolism ; Smad5 Protein/metabolism
Raport
Tytuł:
BMP/Smad Pathway Is Involved in Lithium Carbonate-Induced Neural-Tube Defects in Mice and Neural Stem Cells.
Autorzy:
Yang A; Translational Medicine Laboratory, Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China.
Li S; Translational Medicine Laboratory, Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China.
Zhang Y; Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science & Bioengineering, Beijing University of Technology, Beijing 100124, China.
Wang X; Translational Medicine Laboratory, Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China.
Guan Z; Translational Medicine Laboratory, Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China.
Zhu Z; Translational Medicine Laboratory, Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China.
Liang Y; Translational Medicine Laboratory, Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China.
Zhao L; Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science & Bioengineering, Beijing University of Technology, Beijing 100124, China.
Wang J; Translational Medicine Laboratory, Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Nov 27; Vol. 23 (23). Date of Electronic Publication: 2022 Nov 27.
Typ publikacji:
Journal Article
MeSH Terms:
Neural Stem Cells*/metabolism
Neural Tube Defects*
Mice ; Animals ; Lithium Carbonate/metabolism ; Neurogenesis/physiology ; Signal Transduction/physiology ; Smad1 Protein/genetics ; Smad1 Protein/metabolism
Czasopismo naukowe
Tytuł:
Bmp4 Synexpression Gene, Sizzled, Transcription Is Collectively Modulated by Smad1 and Ventx1.1/Ventx2.1 in Early Xenopus Embryos.
Autorzy:
Rehman ZU; Department of Biochemistry, Institute of Cell Differentiation and Aging, College of Medicine, Hallym University, Chuncheon 24252, Gangwon-Do, Korea.
Tayyaba F; Department of Biochemistry, Institute of Cell Differentiation and Aging, College of Medicine, Hallym University, Chuncheon 24252, Gangwon-Do, Korea.
Lee U; Department of Electrical Engineering, Hallym University, Chuncheon 24252, Gangwon-Do, Korea.
Kim J; Department of Biochemistry, Institute of Cell Differentiation and Aging, College of Medicine, Hallym University, Chuncheon 24252, Gangwon-Do, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Nov 01; Vol. 23 (21). Date of Electronic Publication: 2022 Nov 01.
Typ publikacji:
Journal Article
MeSH Terms:
Xenopus Proteins*/genetics
Xenopus Proteins*/metabolism
Transcription Factors*/metabolism
Animals ; Xenopus laevis/genetics ; Xenopus laevis/metabolism ; Promoter Regions, Genetic ; Binding Sites ; Bone Morphogenetic Protein 4/genetics ; Bone Morphogenetic Protein 4/metabolism ; Smad1 Protein/genetics ; Smad1 Protein/metabolism
Czasopismo naukowe
Tytuł:
TRPM7 Upregulate the Activity of SMAD1 through PLC Signaling Way to Promote Osteogenesis of hBMSCs.
Autorzy:
Hong F; Institute of Cell and Development Biology, College of Life Sciences, Zijingang Campus, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Wu S; Institute of Cell and Development Biology, College of Life Sciences, Zijingang Campus, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Zhang C; Institute of Cell and Development Biology, College of Life Sciences, Zijingang Campus, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Li L; Institute of Cell and Development Biology, College of Life Sciences, Zijingang Campus, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Chen J; Institute of Cell and Development Biology, College of Life Sciences, Zijingang Campus, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Fu Y; Department of ENT, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China.
Wang J; Institute of Cell and Development Biology, College of Life Sciences, Zijingang Campus, Zhejiang University, Hangzhou, Zhejiang 310058, China.; Department of ENT, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China.
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Źródło:
BioMed research international [Biomed Res Int] 2020 May 22; Vol. 2020, pp. 9458983. Date of Electronic Publication: 2020 May 22 (Print Publication: 2020).
Typ publikacji:
Journal Article
MeSH Terms:
Protein Serine-Threonine Kinases*/genetics
Protein Serine-Threonine Kinases*/metabolism
Smad1 Protein*/genetics
Smad1 Protein*/metabolism
TRPM Cation Channels*/genetics
TRPM Cation Channels*/metabolism
Type C Phospholipases*/genetics
Type C Phospholipases*/metabolism
Mesenchymal Stem Cells/*metabolism
Osteogenesis/*genetics
Cells, Cultured ; Humans ; Signal Transduction/genetics ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł:
Tbx2 mediates dorsal patterning and germ layer suppression through inhibition of BMP/GDF and Activin/Nodal signaling.
Autorzy:
Reich S; The Graduate Center, The City University of New York, New York, NY, 10016, USA.
Kayastha P; Department of Biology, Queens College, The City University of New York, Queens, NY, 11367, USA.
Teegala S; Department of Biology, Queens College, The City University of New York, Queens, NY, 11367, USA.
Weinstein DC; The Graduate Center, The City University of New York, New York, NY, 10016, USA. .; Department of Biology, Queens College, The City University of New York, Queens, NY, 11367, USA. .
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Źródło:
BMC molecular and cell biology [BMC Mol Cell Biol] 2020 May 28; Vol. 21 (1), pp. 39. Date of Electronic Publication: 2020 May 28.
Typ publikacji:
Journal Article
MeSH Terms:
Activins/*pharmacology
Ectoderm/*metabolism
Germ Layers/*metabolism
Smad1 Protein/*metabolism
Smad2 Protein/*metabolism
T-Box Domain Proteins/*metabolism
Xenopus Proteins/*metabolism
Animals ; Body Patterning ; Bone Morphogenetic Proteins/metabolism ; Gene Expression Regulation, Developmental/genetics ; Growth Differentiation Factors/metabolism ; Phosphorylation ; Protein Domains/genetics ; Signal Transduction/genetics ; Smad1 Protein/genetics ; Smad2 Protein/genetics ; T-Box Domain Proteins/chemistry ; T-Box Domain Proteins/genetics ; Transforming Growth Factor beta/metabolism ; Xenopus Proteins/genetics ; Xenopus laevis
Czasopismo naukowe
Tytuł:
Zingerone stimulates osteoblast differentiation by increasing Smad1/5/9-mediated HO-1 expression in MC3T3-E1 cells and primary mouse calvarial cells.
Autorzy:
Kim AR; Department of Biotechnology, College of Engineering, Daegu University, Gyeongbuk, Republic of Korea.; Research Institute of Anti-Aging, Daegu University, Gyeongbuk, Republic of Korea.
Lim YJ; Department of Biotechnology, College of Engineering, Daegu University, Gyeongbuk, Republic of Korea.; Research Institute of Anti-Aging, Daegu University, Gyeongbuk, Republic of Korea.
Jang WG; Department of Biotechnology, College of Engineering, Daegu University, Gyeongbuk, Republic of Korea.; Research Institute of Anti-Aging, Daegu University, Gyeongbuk, Republic of Korea.
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Źródło:
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2022 Oct; Vol. 49 (10), pp. 1050-1058. Date of Electronic Publication: 2022 Jul 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Core Binding Factor Alpha 1 Subunit*/genetics
Core Binding Factor Alpha 1 Subunit*/metabolism
Core Binding Factor Alpha 1 Subunit*/pharmacology
Osteoblasts*
Animals ; Bone Morphogenetic Protein 2/metabolism ; Cell Differentiation ; Guaiacol/analogs & derivatives ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/metabolism ; Mice ; Osteocalcin ; Osteogenesis ; Protein Phosphatase 2/genetics ; Protein Phosphatase 2/metabolism ; Smad1 Protein/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
BMP-SMAD1/5 Signaling Regulates Retinal Vascular Development.
Autorzy:
Benn A; Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, 3000 Leuven, Belgium.; VIB-KU Leuven Center for Brain & Disease Research, KU Leuven, 3000 Leuven, Belgium.
Alonso F; Centre de Recherche Cardio-Thoracique de Bordeaux (INSERM U0145), Université de Bordeaux, 33607 Bordeaux, France.
Mangelschots J; Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, 3000 Leuven, Belgium.
Génot E; Centre de Recherche Cardio-Thoracique de Bordeaux (INSERM U0145), Université de Bordeaux, 33607 Bordeaux, France.
Lox M; Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, 3000 Leuven, Belgium.
Zwijsen A; Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, 3000 Leuven, Belgium.
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Źródło:
Biomolecules [Biomolecules] 2020 Mar 23; Vol. 10 (3). Date of Electronic Publication: 2020 Mar 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Embryo, Mammalian*/blood supply
Embryo, Mammalian*/embryology
Neovascularization, Physiologic*
Signal Transduction*
Bone Morphogenetic Proteins/*metabolism
Retina/*embryology
Retinal Vessels/*embryology
Smad1 Protein/*metabolism
Smad5 Protein/*metabolism
Animals ; Bone Morphogenetic Proteins/genetics ; Mice ; Mice, Transgenic ; Smad1 Protein/genetics ; Smad5 Protein/genetics
Czasopismo naukowe
Tytuł:
H 2 O 2 induces oxidative stress damage through the BMP-6/SMAD/hepcidin axis.
Autorzy:
Chen L; Department of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Ma B; Department of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Liu X; Department of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Hao Y; Department of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yang X; Department of Ophthalmology, Xi'an No. 1 Hospital, Xi'an, China.; Shaanxi Institute of Ophthalmology, Xi'an, China.
Liu M; Department of Ophthalmology, Xi'an No. 1 Hospital, Xi'an, China.; Shaanxi Institute of Ophthalmology, Xi'an, China.
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Źródło:
Development, growth & differentiation [Dev Growth Differ] 2020 Feb; Vol. 62 (2), pp. 139-146. Date of Electronic Publication: 2020 Feb 03.
Typ publikacji:
Journal Article
MeSH Terms:
Bone Morphogenetic Protein 6/*metabolism
Hepcidins/*metabolism
Hydrogen Peroxide/*pharmacology
Oxidative Stress/*drug effects
Smad1 Protein/*metabolism
Smad5 Protein/*metabolism
Aged ; Blotting, Western ; Bone Morphogenetic Protein 6/genetics ; Cell Line ; Enzyme-Linked Immunosorbent Assay ; Female ; Hepcidins/genetics ; Humans ; Macular Degeneration ; Male ; Middle Aged ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Smad1 Protein/genetics ; Smad5 Protein/genetics
Czasopismo naukowe
Tytuł:
KR‑12‑a6 promotes the osteogenic differentiation of human bone marrow mesenchymal stem cells via BMP/SMAD signaling.
Autorzy:
Fu L; Department of Orthopedics, Jingzhou Central Hospital, Tongji Medical College of Huazhong University of Science and Technology, Jingzhou, Hubei 434020, P.R. China.
Jin P; Department of Orthopedics, Xiangyang No. 1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China.
Hu Y; Department of Gynecology and Obstetrics, Jingzhou Central Hospital, Tongji Medical College of Huazhong University of Science and Technology, Jingzhou, Hubei 434020, P.R. China.
Lu H; Department of Orthopedics, Jingzhou Central Hospital, Tongji Medical College of Huazhong University of Science and Technology, Jingzhou, Hubei 434020, P.R. China.
Su L; Department of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2020 Jan; Vol. 21 (1), pp. 61-68. Date of Electronic Publication: 2019 Nov 22.
Typ publikacji:
Journal Article
MeSH Terms:
Bone Morphogenetic Protein 2/*metabolism
Imidazoles/*pharmacology
Nylons/*pharmacology
Osteogenesis/*drug effects
Smad1 Protein/*metabolism
Smad5 Protein/*metabolism
Adult ; Alkaline Phosphatase/metabolism ; Bone Morphogenetic Protein 2/genetics ; Cells, Cultured ; Collagen Type I/genetics ; Collagen Type I/metabolism ; Collagen Type I, alpha 1 Chain ; Core Binding Factor Alpha 1 Subunit/genetics ; Core Binding Factor Alpha 1 Subunit/metabolism ; Female ; Humans ; Imidazoles/pharmacokinetics ; Male ; Mesenchymal Stem Cells/drug effects ; Mesenchymal Stem Cells/metabolism ; Nylons/pharmacokinetics ; Osteocalcin/genetics ; Osteocalcin/metabolism ; Osteogenesis/genetics ; Osteopontin/genetics ; Peptide Fragments/genetics ; Signal Transduction/genetics ; Smad1 Protein/antagonists & inhibitors ; Smad5 Protein/antagonists & inhibitors ; Sp7 Transcription Factor/genetics ; Sp7 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł:
BMP2 promotes lung adenocarcinoma metastasis through BMP receptor 2-mediated SMAD1/5 activation.
Autorzy:
Wu CK; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, No. 35, Xiao-Tong Road, Tainan, 704, Taiwan.
Wei MT; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, No. 35, Xiao-Tong Road, Tainan, 704, Taiwan.
Wu HC; Division of Hematology and Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Tainan, Taiwan.; Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan.
Wu CL; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, No. 35, Xiao-Tong Road, Tainan, 704, Taiwan.; Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wu CJ; Departments of Oncology and Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Liaw H; Department of Life Sciences, National Cheng Kung University, No. 1 University Road, Tainan City, 701, Taiwan. .
Su WP; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, No. 35, Xiao-Tong Road, Tainan, 704, Taiwan. .; Departments of Oncology and Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. .
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Źródło:
Scientific reports [Sci Rep] 2022 Sep 29; Vol. 12 (1), pp. 16310. Date of Electronic Publication: 2022 Sep 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adenocarcinoma*/genetics
Adenocarcinoma of Lung*
Carcinoma, Non-Small-Cell Lung*/genetics
Lung Neoplasms*/genetics
Smad5 Protein/*metabolism
Animals ; Bone Morphogenetic Protein 2 ; Humans ; Lymphatic Metastasis ; Mice ; Proto-Oncogene Proteins p21(ras) ; Smad1 Protein
Czasopismo naukowe
Tytuł:
Prohaptoglobin inhibits the transforming growth factor-β-induced epithelial-to-mesenchymal transition in vitro by increasing Smad1/5 activation and suppressing the Smad2/3 signaling pathway in SK-Hep1 liver cancer cells.
Autorzy:
Oh MK; Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul, Korea.; Bio-MAX institute, Seoul National University, Seoul, Korea.
Joo H; Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kim IS; Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul, Korea.
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Źródło:
PloS one [PLoS One] 2022 May 17; Vol. 17 (5), pp. e0266409. Date of Electronic Publication: 2022 May 17 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Haptoglobins*/metabolism
Liver Neoplasms*/genetics
Liver Neoplasms*/metabolism
Liver Neoplasms*/pathology
Smad Proteins*/metabolism
Transforming Growth Factor beta*/metabolism
Cell Line, Tumor ; Cell Movement ; Endothelial Cells/metabolism ; Epithelial-Mesenchymal Transition ; Humans ; Protein Precursors/metabolism ; Signal Transduction ; Smad1 Protein/metabolism ; Smad3 Protein/metabolism ; Smad5 Protein/metabolism
Czasopismo naukowe
Tytuł:
SMAD1/5 signaling in osteoclasts regulates bone formation via coupling factors.
Autorzy:
Tasca A; Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota, United States of America.
Astleford K; Department of Developmental and Surgical Sciences, Division of Orthodontics, University of Minnesota, Minneapolis, Minnesota, United States of America.
Blixt NC; Departmment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, United States of America.
Jensen ED; Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota, United States of America.
Gopalakrishnan R; Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota, United States of America.
Mansky KC; Department of Developmental and Surgical Sciences, Division of Orthodontics, University of Minnesota, Minneapolis, Minnesota, United States of America.
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Źródło:
PloS one [PLoS One] 2018 Sep 06; Vol. 13 (9), pp. e0203404. Date of Electronic Publication: 2018 Sep 06 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Osteogenesis*
Wnt Signaling Pathway*
Osteoclasts/*metabolism
Smad1 Protein/*metabolism
Smad5 Protein/*metabolism
Animals ; Connexin 43/genetics ; Connexin 43/metabolism ; Mice ; Mice, Knockout ; Osteoblasts/cytology ; Osteoblasts/metabolism ; Osteoclasts/cytology ; Smad1 Protein/genetics ; Wnt1 Protein/genetics ; Wnt1 Protein/metabolism
Czasopismo naukowe
Tytuł:
SMAD1 Loss-of-Function Variant Responsible for Congenital Heart Disease.
Autorzy:
Wang Z; Department of Pediatric Internal Medicine, Ningbo Women & Children's Hospital, Ningbo 315031, China.
Qiao XH; Department of Pediatric Internal Medicine, Ningbo Women & Children's Hospital, Ningbo 315031, China.
Xu YJ; Department of Cardiology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
Liu XY; Department of Pediatrics, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Huang RT; Department of Cardiovascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Xue S; Department of Cardiovascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Qiu HY; Department of Pediatric Internal Medicine, Ningbo Women & Children's Hospital, Ningbo 315031, China.
Yang YQ; Department of Cardiology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.; Department of Cardiovascular Research Laboratory, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.; Department of Central Laboratory, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
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Źródło:
BioMed research international [Biomed Res Int] 2022 Mar 03; Vol. 2022, pp. 9916325. Date of Electronic Publication: 2022 Mar 03 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Heart Defects, Congenital*/genetics
Smad1 Protein/*metabolism
Female ; Genes, Reporter ; Heterozygote ; Humans ; Pedigree ; Pregnancy
Czasopismo naukowe
Tytuł:
Duloxetine suppresses BMP-4-induced release of osteoprotegerin via inhibition of the SMAD signaling pathway in osteoblasts.
Autorzy:
Tachi J; Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.; Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Onuma T; Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Yamaguchi S; Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Kim W; Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.; Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Hioki T; Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.; Department of Dermatology, Kizawa Memorial Hospital, Minokamo 505-8503, Japan.
Matsushima-Nishiwaki R; Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Tanabe K; Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Tokuda H; Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.; Department of Clinical Laboratory/Medical Genome Center Biobank, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan.
Kozawa O; Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Iida H; Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
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Źródło:
Biochemistry and cell biology = Biochimie et biologie cellulaire [Biochem Cell Biol] 2021 Oct; Vol. 99 (5), pp. 578-586. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bone Morphogenetic Protein 4/*antagonists & inhibitors
Duloxetine Hydrochloride/*pharmacology
Osteoblasts/*drug effects
Osteoprotegerin/*antagonists & inhibitors
3T3 Cells ; Animals ; Bone Morphogenetic Protein 4/metabolism ; Cells, Cultured ; Dose-Response Relationship, Drug ; Mice ; Osteoblasts/metabolism ; Osteoprotegerin/metabolism ; Signal Transduction/drug effects ; Smad1 Protein/antagonists & inhibitors ; Smad1 Protein/metabolism ; Smad5 Protein/antagonists & inhibitors ; Smad5 Protein/metabolism ; Smad8 Protein/antagonists & inhibitors ; Smad8 Protein/metabolism
Czasopismo naukowe
Tytuł:
Effect of N-Vinyl-2-Pyrrolidone (NVP), a Bromodomain-Binding Small Chemical, on Osteoblast and Osteoclast Differentiation and Its Potential Application for Bone Regeneration.
Autorzy:
Klemmer VA; Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.
Khera N; Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.
Siegenthaler BM; Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.
Bhattacharya I; Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.
Weber FE; Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.; Center for Applied Biotechnology and Molecular Medicine, University of Zurich, 8057 Zurich, Switzerland.
Ghayor C; Oral Biotechnology and Bioengineering, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 13; Vol. 22 (20). Date of Electronic Publication: 2021 Oct 13.
Typ publikacji:
Journal Article
MeSH Terms:
Bone Regeneration/*drug effects
Cell Differentiation/*drug effects
Pyrrolidinones/*pharmacology
Animals ; Bone Diseases/drug therapy ; Bone Diseases/pathology ; Bone Morphogenetic Protein 2/agonists ; Bone Morphogenetic Protein 2/metabolism ; Bone and Bones/pathology ; Cell Survival/drug effects ; Cells, Cultured ; Core Binding Factor Alpha 1 Subunit/metabolism ; Disease Models, Animal ; Mice ; Osteoblasts/cytology ; Osteoblasts/metabolism ; Osteoclasts/cytology ; Osteoclasts/metabolism ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Pyrrolidinones/chemistry ; Pyrrolidinones/therapeutic use ; RANK Ligand/pharmacology ; Rabbits ; Smad1 Protein/metabolism
Czasopismo naukowe
Tytuł:
Abnormal expression levels of BMP15/Smad1 are associated with granulosa cell apoptosis in patients with polycystic ovary syndrome.
Autorzy:
Cui X; Reproductive Medicine Center, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan, Shanxi 030000, P.R. China.
Jing X; Clinical Laboratory, Shanxi Province People's Hospital, Taiyuan, Shanxi 030000, P.R. China.
Wu X; Reproductive Medicine Center, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan, Shanxi 030000, P.R. China.
Bi X; Reproductive Medicine Center, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan, Shanxi 030000, P.R. China.
Liu J; Reproductive Medicine Center, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan, Shanxi 030000, P.R. China.
Long Z; Reproductive Medicine Center, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan, Shanxi 030000, P.R. China.
Zhang X; Reproductive Medicine Center, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan, Shanxi 030000, P.R. China.
Zhang D; Reproductive Medicine Center, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan, Shanxi 030000, P.R. China.
Jia H; Reproductive Medicine Center, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan, Shanxi 030000, P.R. China.
Su D; Reproductive Medicine Center, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan, Shanxi 030000, P.R. China.
Huo K; Department of Neurosurgery, The Tumor Hospital of Shanxi, Taiyuan, Shanxi 030000, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2017 Dec; Vol. 16 (6), pp. 8231-8236. Date of Electronic Publication: 2017 Sep 28.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation*
Apoptosis/*genetics
Bone Morphogenetic Protein 15/*genetics
Granulosa Cells/*metabolism
Polycystic Ovary Syndrome/*genetics
Smad1 Protein/*genetics
Adult ; Biomarkers ; Bone Morphogenetic Protein 15/metabolism ; Bone Morphogenetic Protein Receptors, Type II/genetics ; Bone Morphogenetic Protein Receptors, Type II/metabolism ; Case-Control Studies ; Female ; Fertilization ; Humans ; Polycystic Ovary Syndrome/metabolism ; Smad1 Protein/metabolism
Czasopismo naukowe
Tytuł:
Mechanical stress affects the osteogenic differentiation of human ligamentum flavum cells via the BMP‑Smad1 signaling pathway.
Autorzy:
Shunzhi Y; Department of Orthopedic Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China.
Zhonghai L; Department of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian 116011, P.R. China.
Ning Y; Department of Orthopedic Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2017 Nov; Vol. 16 (5), pp. 7692-7698. Date of Electronic Publication: 2017 Sep 20.
Typ publikacji:
Journal Article
MeSH Terms:
Mechanotransduction, Cellular*
Bone Morphogenetic Proteins/*metabolism
Ligamentum Flavum/*metabolism
Osteoblasts/*metabolism
Osteogenesis/*genetics
Smad1 Protein/*metabolism
Alkaline Phosphatase/genetics ; Alkaline Phosphatase/metabolism ; Biomechanical Phenomena ; Bone Morphogenetic Proteins/genetics ; Cell Differentiation ; Core Binding Factor Alpha 1 Subunit/genetics ; Core Binding Factor Alpha 1 Subunit/metabolism ; Gene Expression Regulation ; Humans ; Ligamentum Flavum/pathology ; Male ; Middle Aged ; Osteoblasts/pathology ; Osteocalcin/genetics ; Osteocalcin/metabolism ; Primary Cell Culture ; Proto-Oncogene Protein c-ets-1/genetics ; Proto-Oncogene Protein c-ets-1/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; SOXB1 Transcription Factors/genetics ; SOXB1 Transcription Factors/metabolism ; Smad1 Protein/genetics ; Stress, Mechanical ; p38 Mitogen-Activated Protein Kinases/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism ; src-Family Kinases/genetics ; src-Family Kinases/metabolism
Czasopismo naukowe
Tytuł:
Smad2/3 Activation Regulates Smad1/5/8 Signaling via a Negative Feedback Loop to Inhibit 3T3-L1 Adipogenesis.
Autorzy:
Aykul S; Department of Biochemistry and Molecular Biology, Michigan State University, 603 Wilson Road, East Lansing, MI 48824, USA.; Regeneron Pharma, Tarrytown, NY 10591, USA.
Maust J; Department of Biochemistry and Molecular Biology, Michigan State University, 603 Wilson Road, East Lansing, MI 48824, USA.
Thamilselvan V; Department of Biochemistry and Molecular Biology, Michigan State University, 603 Wilson Road, East Lansing, MI 48824, USA.
Floer M; Department of Biochemistry and Molecular Biology, Michigan State University, 603 Wilson Road, East Lansing, MI 48824, USA.; Advertent Biotherapeutics, East Lansing, MI 48824, USA.
Martinez-Hackert E; Department of Biochemistry and Molecular Biology, Michigan State University, 603 Wilson Road, East Lansing, MI 48824, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 06; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 06.
Typ publikacji:
Journal Article
MeSH Terms:
Adipogenesis*
Smad2 Protein/*metabolism
Smad3 Protein/*metabolism
3T3-L1 Cells ; Animals ; Mice ; Signal Transduction ; Smad1 Protein/metabolism ; Smad5 Protein/metabolism ; Smad8 Protein/metabolism
Czasopismo naukowe
Tytuł:
MiR-144-5p, an exosomal miRNA from bone marrow-derived macrophage in type 2 diabetes, impairs bone fracture healing via targeting Smad1.
Autorzy:
Zhang D; Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430072, Hubei, China.
Wu Y; Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430072, Hubei, China.
Li Z; Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430072, Hubei, China.
Chen H; Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430072, Hubei, China.
Huang S; Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430072, Hubei, China.
Jian C; Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430072, Hubei, China. .
Yu A; Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430072, Hubei, China. .
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Źródło:
Journal of nanobiotechnology [J Nanobiotechnology] 2021 Jul 30; Vol. 19 (1), pp. 226. Date of Electronic Publication: 2021 Jul 30.
Typ publikacji:
Journal Article
MeSH Terms:
Fracture Healing*
Diabetes Mellitus, Type 2/*metabolism
Macrophages/*metabolism
MicroRNAs/*genetics
Smad1 Protein/*metabolism
Animals ; Bone Regeneration ; Cell Differentiation ; Cell Proliferation/drug effects ; Exosomes ; Fractures, Bone ; Humans ; Male ; Osteoblasts ; Osteogenesis ; Rats, Sprague-Dawley ; Rats
Czasopismo naukowe

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