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Wyszukujesz frazę ""Small-Conductance Calcium-Activated Potassium Channels"" wg kryterium: Temat


Tytuł :
HDAC2-dependent remodeling of K Ca 2.2 (KCNN2) and K Ca 2.3 (KCNN3) K channels in atrial fibrillation with concomitant heart failure.
Autorzy :
Rahm AK; Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; HCR (Heidelberg Center for Heart Rhythm Disorders), University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Wieder T; Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; HCR (Heidelberg Center for Heart Rhythm Disorders), University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Gramlich D; Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; HCR (Heidelberg Center for Heart Rhythm Disorders), University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Müller ME; Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; HCR (Heidelberg Center for Heart Rhythm Disorders), University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Wunsch MN; Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; HCR (Heidelberg Center for Heart Rhythm Disorders), University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
El Tahry FA; Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Heimberger T; Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Weis T; Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Most P; Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Katus HA; Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; HCR (Heidelberg Center for Heart Rhythm Disorders), University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Thomas D; Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; HCR (Heidelberg Center for Heart Rhythm Disorders), University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. Electronic address: .
Lugenbiel P; Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; HCR (Heidelberg Center for Heart Rhythm Disorders), University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
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Źródło :
Life sciences [Life Sci] 2021 Feb 01; Vol. 266, pp. 118892. Date of Electronic Publication: 2020 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Atrial Fibrillation/*physiopathology
Heart Atria/*physiopathology
Heart Failure/*physiopathology
Histone Deacetylase 2/*metabolism
Small-Conductance Calcium-Activated Potassium Channels/*metabolism
Action Potentials ; Animals ; Atrial Fibrillation/complications ; Atrial Fibrillation/metabolism ; Electrophysiological Phenomena ; Female ; Heart Atria/metabolism ; Heart Failure/complications ; Heart Failure/metabolism ; Histone Deacetylase 2/genetics ; Humans ; Male ; Middle Aged ; Small-Conductance Calcium-Activated Potassium Channels/genetics ; Swine
Czasopismo naukowe
Tytuł :
Deciphering the molecular mechanism of SK2 channel activation by intracellular calcium to develop new therapeutic agents.
Autorzy :
Vitello R; Laboratory of Medicinal Chemistry, Department of Pharmacy, CIRM, ULiège, Belgium.
Kerff F; Center for Protein Engineering (CIP), Laboratory of Macromolecule Crystallography, InBioS, ULiège, Belgium.
Liégeois JF; Laboratory of Medicinal Chemistry, Department of Pharmacy, CIRM, ULiège, Belgium.
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Źródło :
Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2021 Jan; Vol. 231 (1), pp. e13574. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Editorial; Comment
MeSH Terms :
Calcium*/metabolism
Small-Conductance Calcium-Activated Potassium Channels*
Cytoplasm ; Hydrophobic and Hydrophilic Interactions
Opinia redakcyjna
Tytuł :
Estrogen-regulated expression of SK3 channel in rat colonic smooth muscle contraction.
Autorzy :
Xiong W; Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Jiang Y; Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Yu T; Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Zheng Y; Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Jiang L; Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Shen X; Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Tang Y; Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Electronic address: .
Lin L; Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
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Źródło :
Life sciences [Life Sci] 2020 Dec 15; Vol. 263, pp. 118549. Date of Electronic Publication: 2020 Oct 09.
Typ publikacji :
Journal Article
MeSH Terms :
Muscle Contraction*
Calcium/*metabolism
Colon/*metabolism
Estrogens/*pharmacology
Gene Expression Regulation/*drug effects
Muscle, Smooth/*metabolism
Small-Conductance Calcium-Activated Potassium Channels/*metabolism
Animals ; Cells, Cultured ; Colon/cytology ; Colon/drug effects ; Female ; Muscle, Smooth/cytology ; Muscle, Smooth/drug effects ; Rats ; Rats, Sprague-Dawley ; Small-Conductance Calcium-Activated Potassium Channels/genetics ; Sp1 Transcription Factor/genetics ; Sp1 Transcription Factor/metabolism ; Sp3 Transcription Factor/genetics ; Sp3 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
SK2 channel regulation of neuronal excitability, synaptic transmission, and brain rhythmic activity in health and diseases.
Autorzy :
Sun J; College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, United States of America; Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, United States of America.
Liu Y; College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, United States of America; Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, United States of America.
Baudry M; College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, United States of America; Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, United States of America.
Bi X; College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, United States of America; Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, United States of America. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2020 Dec; Vol. 1867 (12), pp. 118834. Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Neuronal Plasticity/*genetics
Neurons/*metabolism
Small-Conductance Calcium-Activated Potassium Channels/*genetics
Synaptic Transmission/*genetics
Calcium/metabolism ; Hippocampus/metabolism ; Humans ; Signal Transduction/genetics ; Small-Conductance Calcium-Activated Potassium Channels/metabolism
Czasopismo naukowe
Tytuł :
Coronary endothelial dysfunction prevented by small-conductance calcium-activated potassium channel activator in mice and patients with diabetes.
Autorzy :
Zhang Z; Division of Cardiothoracic Surgery, Rhode Island Hospital, Providence, RI.
Shi G; Division of Cardiothoracic Surgery, Rhode Island Hospital, Providence, RI.
Liu Y; Division of Cardiothoracic Surgery, Rhode Island Hospital, Providence, RI.
Xing H; Division of Cardiothoracic Surgery, Rhode Island Hospital, Providence, RI.
Kabakov AY; Cardiovascular Research Center, Rhode Island Hospital, Providence, RI.
Zhao AS; Division of Cardiothoracic Surgery, Rhode Island Hospital, Providence, RI.
Agbortoko V; Division of Cardiothoracic Surgery, Rhode Island Hospital, Providence, RI.
Kim J; Division of Cardiothoracic Surgery, Rhode Island Hospital, Providence, RI.
Singh AK; Division of Cardiothoracic Surgery, Rhode Island Hospital, Providence, RI.
Koren G; Cardiovascular Research Center, Rhode Island Hospital, Providence, RI.
Harrington EO; Ocean State Research Institute, Providence VA Medical Center, Providence, RI.
Sellke FW; Division of Cardiothoracic Surgery, Rhode Island Hospital, Providence, RI.
Feng J; Division of Cardiothoracic Surgery, Rhode Island Hospital, Providence, RI. Electronic address: .
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Źródło :
The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2020 Dec; Vol. 160 (6), pp. e263-e280. Date of Electronic Publication: 2020 Feb 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Coronary Artery Disease/*etiology
Coronary Vessels/*pathology
Diabetes Mellitus, Type 2/*complications
Endothelium, Vascular/*metabolism
Indoles/*pharmacology
Oximes/*pharmacology
Small-Conductance Calcium-Activated Potassium Channels/*metabolism
Vasodilation/*drug effects
Aged ; Animals ; Cells, Cultured ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/metabolism ; Coronary Vessels/drug effects ; Coronary Vessels/metabolism ; Diabetes Mellitus, Experimental ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/pathology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/pathology ; Female ; Humans ; Male ; Mice ; Signal Transduction ; Small-Conductance Calcium-Activated Potassium Channels/drug effects
Czasopismo naukowe
Tytuł :
PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts.
Autorzy :
Hamilton S; Department of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA.; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, USA.
Polina I; Department of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.; Medical University of South Carolina, Department of Medicine, Division of Nephrology, Charleston, SC, USA.
Terentyeva R; Department of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA.; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, USA.
Bronk P; Department of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.
Kim TY; Department of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.
Roder K; Department of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.
Clements RT; Department of Surgery, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.; Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Providence, RI, USA.
Koren G; Department of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.
Choi BR; Department of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.
Terentyev D; Department of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA.; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, USA.
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Źródło :
The Journal of physiology [J Physiol] 2020 Jul; Vol. 598 (14), pp. 2847-2873. Date of Electronic Publication: 2019 Mar 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Myocytes, Cardiac*/metabolism
Small-Conductance Calcium-Activated Potassium Channels*/genetics
Small-Conductance Calcium-Activated Potassium Channels*/metabolism
Animals ; Apamin ; Cardiomegaly/metabolism ; Phosphorylation ; Rats
Czasopismo naukowe
Tytuł :
Ik Ca and SK Ca might participate in preeclampsia through regulating placental angiogenesis.
Autorzy :
Li F; Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Xie Y; Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
He M; Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Fan Y; Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Yang M; Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Wang S; Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Li X; Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Sun Y; Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Xu H; Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Liu X; Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Deng D; Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: .
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Źródło :
Pregnancy hypertension [Pregnancy Hypertens] 2020 Jul; Vol. 21, pp. 90-95. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Journal Article
MeSH Terms :
Neovascularization, Pathologic*
Human Umbilical Vein Endothelial Cells/*metabolism
Intermediate-Conductance Calcium-Activated Potassium Channels/*metabolism
Placenta/*blood supply
Pre-Eclampsia/*metabolism
Small-Conductance Calcium-Activated Potassium Channels/*metabolism
Apoptosis ; Cell Movement ; Cell Proliferation ; Cells, Cultured ; Female ; Fibroblast Growth Factors/metabolism ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/pathology ; Humans ; Insulin-Like Growth Factor I/metabolism ; Intermediate-Conductance Calcium-Activated Potassium Channels/antagonists & inhibitors ; Potassium Channel Blockers/pharmacology ; Pre-Eclampsia/drug therapy ; Pre-Eclampsia/pathology ; Pregnancy ; Signal Transduction ; Small-Conductance Calcium-Activated Potassium Channels/antagonists & inhibitors ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome.
Autorzy :
Sun J; College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, 91766, USA.
Liu Y; Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, 91766, USA.
Zhu G; Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, 91766, USA.; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, 230038, China.
Cato C; College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, 91766, USA.
Hao X; College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, 91766, USA.
Qian L; College of Pharmacy, Western University of Health Sciences, Pomona, CA, 91766, USA.
Lin W; Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, 91766, USA.
Adhikari R; College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, 91766, USA.
Luo Y; College of Pharmacy, Western University of Health Sciences, Pomona, CA, 91766, USA.
Baudry M; Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, 91766, USA.
Bi X; College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, 91766, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jun 17; Vol. 10 (1), pp. 9824. Date of Electronic Publication: 2020 Jun 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Neuronal Plasticity*
Angelman Syndrome/*physiopathology
Cyclic AMP-Dependent Protein Kinases/*metabolism
Hippocampus/*pathology
Small-Conductance Calcium-Activated Potassium Channels/*metabolism
Synapses/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Amino Acid Sequence ; Angelman Syndrome/metabolism ; Angelman Syndrome/pathology ; Animals ; CA1 Region, Hippocampal/pathology ; CA1 Region, Hippocampal/physiopathology ; COS Cells ; Chlorocebus aethiops ; Endocytosis ; Hippocampus/physiopathology ; Long-Term Potentiation ; Mice ; Models, Molecular ; Mutation ; Phosphorylation ; Protein Domains ; Protein Transport ; Small-Conductance Calcium-Activated Potassium Channels/chemistry ; Small-Conductance Calcium-Activated Potassium Channels/genetics ; Ubiquitination
Czasopismo naukowe
Tytuł :
Inhibitory Effects of Dronedarone on Small Conductance Calcium Activated Potassium Channels in Patients with Chronic Atrial Fibrillation: Comparison to Amiodarone.
Autorzy :
Yu Y; Key Laboratory of Medical Electrophysiology of Ministry of Education, Medical Electrophysiology Key Lab of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, China (mainland).; Department of Electrocardiography, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China (mainland).
Luo D; Key Laboratory of Medical Electrophysiology of Ministry of Education, Medical Electrophysiology Key Lab of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, China (mainland).
Li Z; Key Laboratory of Medical Electrophysiology of Ministry of Education, Medical Electrophysiology Key Lab of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, China (mainland).
Zhang J; Key Laboratory of Medical Electrophysiology of Ministry of Education, Medical Electrophysiology Key Lab of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, China (mainland).
Li F; Key Laboratory of Medical Electrophysiology of Ministry of Education, Medical Electrophysiology Key Lab of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, China (mainland).
Qiao J; Key Laboratory of Medical Electrophysiology of Ministry of Education, Medical Electrophysiology Key Lab of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, China (mainland).
Yu F; Department of Cardiothoracic Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China (mainland).
Li M; Key Laboratory of Medical Electrophysiology of Ministry of Education, Medical Electrophysiology Key Lab of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, China (mainland).; Department of Cardiothoracic Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China (mainland).
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Źródło :
Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2020 May 29; Vol. 26, pp. e924215. Date of Electronic Publication: 2020 May 29.
Typ publikacji :
Journal Article
MeSH Terms :
Atrial Fibrillation/*drug therapy
Dronedarone/*pharmacology
Small-Conductance Calcium-Activated Potassium Channels/*drug effects
Adult ; Amiodarone/metabolism ; Amiodarone/pharmacology ; Anti-Arrhythmia Agents/therapeutic use ; Atrial Fibrillation/metabolism ; Calcium/metabolism ; Dronedarone/metabolism ; Female ; HEK293 Cells ; Heart Atria/physiopathology ; Humans ; Male ; Middle Aged ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Potassium Channels/drug effects ; Potassium Channels/metabolism ; Small-Conductance Calcium-Activated Potassium Channels/metabolism
Czasopismo naukowe
Tytuł :
Kcnn2 blockade reverses learning deficits in a mouse model of fetal alcohol spectrum disorders.
Autorzy :
Mohammad S; Center for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, DC, USA.
Page SJ; Center for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, DC, USA.
Wang L; Center for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, DC, USA.
Ishii S; Center for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, DC, USA.
Li P; Center for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, DC, USA.; Wenzhou Medical University, Ouhai, Wenzhou, China.
Sasaki T; Center for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, DC, USA.; Department of Obstetrics and Gynecology, Tokyo Medical University, Tokyo, Japan.
Basha A; Center for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, DC, USA.
Salzberg A; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Quezado Z; The Sheikh Zayed Institute for Pediatric Surgical Innovation, Division of Anesthesiology, Pain and Perioperative Medicine, Children's National Hospital, Washington, DC, USA.
Imamura F; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Nishi H; Department of Obstetrics and Gynecology, Tokyo Medical University, Tokyo, Japan.
Isaka K; Department of Obstetrics and Gynecology, Tokyo Medical University, Tokyo, Japan.
Corbin JG; Center for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, DC, USA.; Department of Pediatrics, Pharmacology and Physiology, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.
Liu JS; Department of Neurology, Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA.
Kawasawa YI; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA. .; Department of Biochemistry and Molecular Biology, Institute for Personalized Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA. .
Torii M; Center for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, DC, USA. .; Department of Pediatrics, Pharmacology and Physiology, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA. .
Hashimoto-Torii K; Center for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, DC, USA. .; Department of Pediatrics, Pharmacology and Physiology, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA. .
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Źródło :
Nature neuroscience [Nat Neurosci] 2020 Apr; Vol. 23 (4), pp. 533-543. Date of Electronic Publication: 2020 Mar 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Behavior, Animal/*drug effects
Fetal Alcohol Spectrum Disorders/*drug therapy
Learning/*drug effects
Learning Disabilities/*drug therapy
Motor Cortex/*drug effects
Scorpion Venoms/*pharmacology
Small-Conductance Calcium-Activated Potassium Channels/*antagonists & inhibitors
Animals ; Cell Shape/drug effects ; Dendrites/drug effects ; Dendrites/metabolism ; Disease Models, Animal ; Learning Disabilities/metabolism ; Mice ; Motor Activity/drug effects ; Motor Cortex/metabolism ; Neurons/drug effects ; Neurons/metabolism ; Scorpion Venoms/therapeutic use ; Small-Conductance Calcium-Activated Potassium Channels/metabolism
Czasopismo naukowe
Tytuł :
Activation of small conductance calcium-activated potassium channels suppresses seizure susceptibility in the genetically epilepsy-prone rats.
Autorzy :
Khandai P; Departments of Pediatrics, Georgetown University Medical Center, Washington, USA.
Forcelli PA; Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington DC, USA; Department of Neuroscience, Georgetown University Medical Center, Washington DC, USA; Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington DC, USA.
N'Gouemo P; Departments of Pediatrics, Georgetown University Medical Center, Washington, USA; Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington DC, USA; Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington DC, USA. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2020 Feb; Vol. 163, pp. 107865. Date of Electronic Publication: 2019 Nov 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Benzimidazoles/*pharmacology
Epilepsy/*genetics
Seizures/*drug therapy
Small-Conductance Calcium-Activated Potassium Channels/*agonists
Action Potentials ; Animals ; Female ; Male ; Rats ; Small-Conductance Calcium-Activated Potassium Channels/metabolism
Czasopismo naukowe
Tytuł :
Small and intermediate Ca channels do not play a role in vascular conductance during resting blood flow in the anaesthetised pig.
Autorzy :
Ruane-O'Hora T; Department of Physiology, University College Cork, Western Gateway Building, Cork, Ireland.
Markos F; Department of Physiology, University College Cork, Western Gateway Building, Cork, Ireland. .
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Źródło :
Heart and vessels [Heart Vessels] 2020 Feb; Vol. 35 (2), pp. 284-289. Date of Electronic Publication: 2019 Aug 31.
Typ publikacji :
Journal Article
MeSH Terms :
Vasodilation*/drug effects
Iliac Artery/*metabolism
Intermediate-Conductance Calcium-Activated Potassium Channels/*metabolism
Potassium/*metabolism
Small-Conductance Calcium-Activated Potassium Channels/*metabolism
Anesthesia, General ; Animals ; Arterial Pressure ; Blood Flow Velocity ; Female ; Iliac Artery/drug effects ; Intermediate-Conductance Calcium-Activated Potassium Channels/antagonists & inhibitors ; Models, Animal ; Potassium Channel Blockers/pharmacology ; Signal Transduction ; Small-Conductance Calcium-Activated Potassium Channels/antagonists & inhibitors ; Sus scrofa ; Vascular Resistance
Czasopismo naukowe
Tytuł :
Pharmacology of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels.
Autorzy :
Brown BM; Department of Pharmacology, University of California, Davis, California 95616, USA; email: .
Shim H; Department of Pharmacology, University of California, Davis, California 95616, USA; email: .
Christophersen P; Saniona A/S, DK-2750 Ballerup, Denmark; email: .
Wulff H; Department of Pharmacology, University of California, Davis, California 95616, USA; email: .
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Źródło :
Annual review of pharmacology and toxicology [Annu Rev Pharmacol Toxicol] 2020 Jan 06; Vol. 60, pp. 219-240. Date of Electronic Publication: 2019 Jul 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Intermediate-Conductance Calcium-Activated Potassium Channels/*drug effects
Small-Conductance Calcium-Activated Potassium Channels/*drug effects
Animals ; Binding Sites ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/physiopathology ; Humans ; Intermediate-Conductance Calcium-Activated Potassium Channels/metabolism ; Nervous System Diseases/drug therapy ; Nervous System Diseases/physiopathology ; Potassium Channel Blockers/pharmacology ; Small-Conductance Calcium-Activated Potassium Channels/metabolism
Czasopismo naukowe
Tytuł :
SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces.
Autorzy :
Grasselli G; Department of Neurobiology, University of Chicago, Chicago, Illinois, United States of America.
Boele HJ; Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.
Titley HK; Department of Neurobiology, University of Chicago, Chicago, Illinois, United States of America.
Bradford N; Department of Neurobiology, University of Chicago, Chicago, Illinois, United States of America.
van Beers L; Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.
Jay L; Department of Neurobiology, University of Chicago, Chicago, Illinois, United States of America.
Beekhof GC; Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.
Busch SE; Department of Neurobiology, University of Chicago, Chicago, Illinois, United States of America.
De Zeeuw CI; Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.; Netherlands Institute for Neuroscience, Royal Academy of Sciences, Amsterdam, The Netherlands.
Schonewille M; Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.
Hansel C; Department of Neurobiology, University of Chicago, Chicago, Illinois, United States of America.
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Źródło :
PLoS biology [PLoS Biol] 2020 Jan 06; Vol. 18 (1), pp. e3000596. Date of Electronic Publication: 2020 Jan 06 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Action Potentials/*genetics
Learning/*physiology
Memory/*physiology
Motor Activity/*physiology
Purkinje Cells/*metabolism
Small-Conductance Calcium-Activated Potassium Channels/*physiology
Animals ; Cerebellum/cytology ; Cerebellum/metabolism ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neuronal Plasticity/physiology ; Reflex, Vestibulo-Ocular ; Small-Conductance Calcium-Activated Potassium Channels/metabolism
Czasopismo naukowe
Tytuł :
SK channel activation potentiates auranofin-induced cell death in glio- and neuroblastoma cells.
Autorzy :
Krabbendam IE; Faculty of Science and Engineering, Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, 9713 AV Groningen, the Netherlands. Electronic address: .
Honrath B; Faculty of Science and Engineering, Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, 9713 AV Groningen, the Netherlands.
Bothof L; Faculty of Science and Engineering, Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, 9713 AV Groningen, the Netherlands.
Silva-Pavez E; Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile and Geroscience Center for Brain Health and Metabolism, Santiago, Chile.
Huerta H; Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile and Geroscience Center for Brain Health and Metabolism, Santiago, Chile.
Peñaranda Fajardo NM; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Dekker F; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, the Netherlands.
Schmidt M; Faculty of Science and Engineering, Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, 9713 AV Groningen, the Netherlands.
Culmsee C; Institut für Pharmakologie und Klinische Pharmazie, Biochemisch-Pharmakologisches Centrum Marburg, Philipps-Universität Marburg, Karl-von-Frisch-Straße 2, Marburg 35032, Germany; Center for Mind, Brain and Behavior, Universities of Marburg and Gießen, Hans-Meerwein-Straße 6, 35032 Marburg, Germany.
César Cárdenas J; Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile and Geroscience Center for Brain Health and Metabolism, Santiago, Chile; Buck Institute for Research on Aging, Novato, CA 94945, United States; Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, United States.
Kruyt F; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Dolga AM; Faculty of Science and Engineering, Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, 9713 AV Groningen, the Netherlands. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Jan; Vol. 171, pp. 113714. Date of Electronic Publication: 2019 Nov 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Auranofin/*pharmacology
Brain Neoplasms/*metabolism
Glioblastoma/*metabolism
Neuroblastoma/*metabolism
Pyrazoles/*pharmacology
Pyrimidines/*pharmacology
Small-Conductance Calcium-Activated Potassium Channels/*agonists
Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Auranofin/administration & dosage ; Brain Neoplasms/drug therapy ; Brain Neoplasms/pathology ; Cell Death/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Synergism ; Glioblastoma/drug therapy ; Glioblastoma/pathology ; Humans ; Mice ; Mitochondria/drug effects ; Mitochondria/metabolism ; Neuroblastoma/drug therapy ; Neuroblastoma/pathology ; Pyrazoles/administration & dosage ; Pyrimidines/administration & dosage ; Small-Conductance Calcium-Activated Potassium Channels/metabolism ; Spheroids, Cellular/drug effects ; Thioredoxin-Disulfide Reductase/antagonists & inhibitors ; Thioredoxin-Disulfide Reductase/metabolism
Czasopismo naukowe
Tytuł :
Variants in the SK2 channel gene (KCNN2) lead to dominant neurodevelopmental movement disorders.
Autorzy :
Mochel F; Institut du Cerveau et de la Moelle épinière (ICM), Sorbonne Université, UMR S 1127, Inserm U1127, CNRS UMR 7225, F-75013 Paris, France.; AP-HP, Hôpital Pitié-Salpêtrière, Département de Génétique and Centre de Référence Neurométabolique Adulte, F-75013, Paris, France.
Rastetter A; Institut du Cerveau et de la Moelle épinière (ICM), Sorbonne Université, UMR S 1127, Inserm U1127, CNRS UMR 7225, F-75013 Paris, France.
Ceulemans B; Division of Paediatric Neurology, Antwerp University Hospital, University of Antwerp, Edegem, Belgium.
Platzer K; Institute of Human Genetics, University of Leipzig Medical Center, Leipzig, Germany.
Yang S; GeneDx, Gaithersburg, MD 20877, USA.
Shinde DN; Department of Clinical Diagnostics, Ambry Genetics, Aliso Viejo, CA, USA.
Helbig KL; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; The Epilepsy Neurogenetics Initiative, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Lopergolo D; Medical Genetics, University of Siena, Siena, Italy.; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Mari F; Medical Genetics, University of Siena, Siena, Italy.; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Renieri A; Medical Genetics, University of Siena, Siena, Italy.; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Benetti E; Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Canitano R; Division of Child and Adolescent Neuropsychiatry, University Hospital of Siena, Siena, Italy.
Waisfisz Q; Department of Clinical Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Plomp AS; Department of Clinical Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Huisman SA; Department of Pediatrics, Amsterdam UMC, Amsterdam, The Netherlands.; Prinsenstichting, Purmerend, The Netherlands.
Wilson GN; Department of Pediatrics, Texas Tech University Health Science Center, Lubbock, Texas, USA.
Cathey SS; Greenwood Genetic Center, Greenwood, South Carolina, 29646, USA.
Louie RJ; Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA.
Gaudio DD; Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA.
Waggoner D; Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA.
Kacker S; Department of Pediatrics, Section of Child Neurology, University of Chicago, Chicago, IL, 60637, USA.
Nugent KM; Department of Pediatrics, Baylor College of Medicine, San Antonio, TX, 78207, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Roeder ER; Department of Pediatrics, Baylor College of Medicine, San Antonio, TX, 78207, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Bruel AL; UMR1231 GAD, Inserm - Université Bourgogne-Franche Comté, Dijon, France.; Centre de référence maladies rares 'déficiences intellectuelles de causes rares', Centre de Génétique, FHU-TRANSLAD, CHU Dijon Bourgogne, Dijon, France.
Thevenon J; Service de Génétique, Génomique, et Procréation, Centre Hospitalier Universitaire Grenoble Alpes, 38700 La Tronche, France.; INSERM 1209, CNRS UMR 5309, Institute for Advanced Biosciences, Université Grenoble Alpes, 38706 Grenoble, France.
Ehmke N; Institute for Human Genetics and Medical Genetics, Charité - Universitaetsmedizin Berlin, Berlin, Germany.
Horn D; Institute for Human Genetics and Medical Genetics, Charité - Universitaetsmedizin Berlin, Berlin, Germany.
Holtgrewe M; Core Unit Bioinformatics - CUBI, Berlin Institute of Health (BIH), Berlin, Germany.
Kaiser FJ; Institute of Human Genetics, University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45147 Essen, Germany.
Kamphausen SB; Institute of Human Genetics, University Hospital Magdeburg, Magdeburg, Germany.
Abou Jamra R; Institute of Human Genetics, University of Leipzig Medical Center, Leipzig, Germany.
Weckhuysen S; Applied and Translational Neurogenomics Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Translational Neurosciences, Faculty of Medicine and Health Science, University of Antwerp, Antwerp, Belgium.; Department of Neurology, University Hospital Antwerp, Antwerp, Belgium.
Dalle C; Institut du Cerveau et de la Moelle épinière (ICM), Sorbonne Université, UMR S 1127, Inserm U1127, CNRS UMR 7225, F-75013 Paris, France.
Depienne C; Institut du Cerveau et de la Moelle épinière (ICM), Sorbonne Université, UMR S 1127, Inserm U1127, CNRS UMR 7225, F-75013 Paris, France.; Institute of Human Genetics, University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45147 Essen, Germany.
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Źródło :
Brain : a journal of neurology [Brain] 2020 Dec 01; Vol. 143 (12), pp. 3564-3573.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Movement Disorders/*genetics
Neurodevelopmental Disorders/*genetics
Small-Conductance Calcium-Activated Potassium Channels/*genetics
Adolescent ; Adult ; Cerebellar Ataxia/genetics ; Cerebellar Ataxia/psychology ; Child ; Child, Preschool ; Electrophysiological Phenomena ; Exome ; Frameshift Mutation ; Genetic Variation ; Haploinsufficiency ; Humans ; Intellectual Disability/genetics ; Intellectual Disability/psychology ; Learning Disabilities/genetics ; Learning Disabilities/psychology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Movement Disorders/psychology ; Mutation, Missense/genetics ; Neurodevelopmental Disorders/psychology ; Patch-Clamp Techniques ; White Matter/abnormalities ; White Matter/diagnostic imaging ; Young Adult
Czasopismo naukowe
Tytuł :
Melatonin Improves Memory Deficits in Rats with Cerebral Hypoperfusion, Possibly, Through Decreasing the Expression of Small-Conductance Ca Channels.
Autorzy :
Al Dera H; Department of Basic Medical Sciences, College of Medicine At King Saud, Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Kingdom of Saudi Arabia. .; King Abdullah International Medical Research Center (KAIMRC), Riyadh, Kingdom of Saudi Arabia. .
Alassiri M; Department of Basic Medical Sciences, College of Medicine At King Saud, Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Kingdom of Saudi Arabia.; King Abdullah International Medical Research Center (KAIMRC), Riyadh, Kingdom of Saudi Arabia.
Eleawa SM; Department of Applied Medical Sciences, College of Health Sciences, Dept., PAAET, Adailiyah, Kuwait.
AlKhateeb MA; Department of Basic Medical Sciences, College of Medicine At King Saud, Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Kingdom of Saudi Arabia.
Hussein AM; Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Dallak M; Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Sakr HF; Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.; Department of Medical Physiology, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia.
Alqahtani S; Department of Basic Medical Sciences, College of Medicine At King Saud, Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Kingdom of Saudi Arabia.; King Abdullah International Medical Research Center (KAIMRC), Riyadh, Kingdom of Saudi Arabia.
Khalil MA; Department of Basic Medical Sciences, College of Medicine, King Fahid Medical City, Riyadh, Kingdom of Saudi Arabia.
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Źródło :
Neurochemical research [Neurochem Res] 2019 Aug; Vol. 44 (8), pp. 1851-1868. Date of Electronic Publication: 2019 Jun 11.
Typ publikacji :
Journal Article
MeSH Terms :
Melatonin/*therapeutic use
Memory Disorders/*drug therapy
Small-Conductance Calcium-Activated Potassium Channels/*metabolism
Animals ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism ; Down-Regulation/drug effects ; Hippocampus/drug effects ; Interleukin-1beta/genetics ; Interleukin-1beta/metabolism ; Male ; Memory Disorders/metabolism ; Mitogen-Activated Protein Kinases/genetics ; Mitogen-Activated Protein Kinases/metabolism ; Oxidative Stress/drug effects ; RNA, Messenger/metabolism ; Rats, Wistar ; Small-Conductance Calcium-Activated Potassium Channels/genetics ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Gain-of-Function Mutations in KCNN3 Encoding the Small-Conductance Ca Channel SK3 Cause Zimmermann-Laband Syndrome.
Autorzy :
Bauer CK; Department of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. Electronic address: .
Schneeberger PE; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Kortüm F; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Altmüller J; Cologne Center for Genomics University of Cologne, 50931 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.
Santos-Simarro F; Sección de Genética Clínica, Instituto de Genética Médica y Molecular (INGEMM), Hospital Universitario La Paz, IdiPAZ, CIBERER, ISCIII, 28046 Madrid, Spain.
Baker L; Division of Medical Genetics, Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA.
Keller-Ramey J; GeneDx, Gaithersburg, MD 20877, USA.
White SM; Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, VIC 3052, Australia; Department of Paediatrics, University of Melbourne, Melbourne, VIC 3010, Australia.
Campeau PM; Department of Pediatrics, Sainte-Justine Hospital, University of Montreal, Montréal, QC H3T 1C5, Canada.
Gripp KW; Division of Medical Genetics, Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA.
Kutsche K; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. Electronic address: .
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Źródło :
American journal of human genetics [Am J Hum Genet] 2019 Jun 06; Vol. 104 (6), pp. 1139-1157. Date of Electronic Publication: 2019 May 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gain of Function Mutation*
Abnormalities, Multiple/*etiology
Craniofacial Abnormalities/*etiology
Fibromatosis, Gingival/*etiology
Hand Deformities, Congenital/*etiology
Small-Conductance Calcium-Activated Potassium Channels/*genetics
Abnormalities, Multiple/pathology ; Adult ; Amino Acid Sequence ; Animals ; CHO Cells ; Child ; Child, Preschool ; Craniofacial Abnormalities/pathology ; Cricetinae ; Cricetulus ; Female ; Fibromatosis, Gingival/pathology ; Hand Deformities, Congenital/pathology ; Humans ; Ion Channel Gating ; Male ; Middle Aged ; Phenotype ; Protein Conformation ; Sequence Homology ; Small-Conductance Calcium-Activated Potassium Channels/chemistry ; Small-Conductance Calcium-Activated Potassium Channels/metabolism
SCR Disease Name :
Zimmerman Laband syndrome
Czasopismo naukowe
Tytuł :
Small-Conductance, Calcium-Activated Potassium Channels: A Key Circuit Determinant for Stress-Induced Amygdala Dysfunction.
Autorzy :
Morel C; Department of Pharmacological Sciences, Nash Family Department of Neuroscience, Friedman Brain Institute, and the Center for Affective Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York.
Montgomery S; Department of Pharmacological Sciences, Nash Family Department of Neuroscience, Friedman Brain Institute, and the Center for Affective Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York.
Han MH; Department of Pharmacological Sciences, Nash Family Department of Neuroscience, Friedman Brain Institute, and the Center for Affective Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: .
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Źródło :
Biological psychiatry [Biol Psychiatry] 2019 May 15; Vol. 85 (10), pp. 784-786.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Comment
MeSH Terms :
Amygdala*
Small-Conductance Calcium-Activated Potassium Channels*
Down-Regulation ; Neurons
Czasopismo naukowe

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