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Tytuł :
SUMO1 modification of IGF-1R combining with SNAI2 inhibited osteogenic differentiation of PDLSCs stimulated by high glucose.
Autorzy :
Jiang R; Department of Stomatology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, Jiangsu, China.
Wang M; Department of Stomatology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, Jiangsu, China.
Shen X; Department of Stomatology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, Jiangsu, China.
Huang S; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Nantong University, Nantong, 226001, Jiangsu, China.
Han J; Department of Stomatology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, Jiangsu, China.
Li L; Department of Stomatology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, Jiangsu, China.
Xu Z; Department of Stomatology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, Jiangsu, China.
Jiang C; Department of Stomatology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, Jiangsu, China.
Zhou Q; Department of Stomatology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, Jiangsu, China. .
Feng X; Department of Stomatology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, Jiangsu, China. .
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Źródło :
Stem cell research & therapy [Stem Cell Res Ther] 2021 Oct 18; Vol. 12 (1), pp. 543. Date of Electronic Publication: 2021 Oct 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Osteogenesis*
Periodontal Ligament*
Snail Family Transcription Factors*/genetics
Receptor, IGF Type 1/*genetics
SUMO-1 Protein/*genetics
Adolescent ; Cell Differentiation ; Cells, Cultured ; Glucose/pharmacology ; Humans ; Stem Cells
Czasopismo naukowe
Tytuł :
Competing Endogenous RNA of Snail and Zeb1 UTR in Therapeutic Resistance of Colorectal Cancer.
Autorzy :
Kim NH; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Song SH; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Choi YH; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Hwang KH; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Yun JS; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Song H; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Cha SY; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Cho SB; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Lee I; Research Division, miRCore, Ann Arbor, MI 48105, USA.
Kim HS; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
Yook JI; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 03; Vol. 22 (17). Date of Electronic Publication: 2021 Sep 03.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, Tumor Suppressor*
Colorectal Neoplasms/*metabolism
MicroRNAs/*metabolism
Neoplasm Proteins/*metabolism
RNA, Neoplasm/*metabolism
Snail Family Transcription Factors/*metabolism
Zinc Finger E-box-Binding Homeobox 1/*metabolism
Animals ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/therapy ; Female ; HCT116 Cells ; Humans ; Mice ; Mice, Nude ; MicroRNAs/genetics ; Neoplasm Proteins/genetics ; RNA, Neoplasm/genetics ; Snail Family Transcription Factors/genetics ; Zinc Finger E-box-Binding Homeobox 1/genetics
Czasopismo naukowe
Tytuł :
Snail Upregulates Transcription of FN, LEF, COX2, and COL1A1 in Hepatocellular Carcinoma: A General Model Established for Snail to Transactivate Mesenchymal Genes.
Autorzy :
Ly TM; Institute of Medical Sciences, Tzu Chi University, Hualien 970, Taiwan.
Chen YC; Division of General Surgery, Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.
Lee MC; Division of General Surgery, Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and School of Medicine, Tzu Chi University, Hualien 970, Taiwan.
Hu CT; Division of Gastroenterology, Department of Medicine, Research Centre for Hepatology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.
Cheng CC; Department of Laboratory Medicine and Biotechnology, College of Medicine, Tzu Chi University, Hualien 970, Taiwan.
Chang HH; Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien 970, Taiwan.
You RI; Department of Laboratory Medicine and Biotechnology, College of Medicine, Tzu Chi University, Hualien 970, Taiwan.
Wu WS; Division of General Surgery, Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.
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Źródło :
Cells [Cells] 2021 Aug 26; Vol. 10 (9). Date of Electronic Publication: 2021 Aug 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Hepatocellular/*genetics
Snail Family Transcription Factors/*metabolism
Carcinoma, Hepatocellular/metabolism ; Cell Line ; Collagen Type I/metabolism ; Cyclooxygenase 2/metabolism ; Fibronectins/metabolism ; Gene Expression/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Hep G2 Cells ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Lymphoid Enhancer-Binding Factor 1/metabolism ; Mesenchymal Stem Cells/metabolism ; Promoter Regions, Genetic/genetics ; Protein Binding/genetics ; Snail Family Transcription Factors/genetics ; Snail Family Transcription Factors/physiology ; Transcription Factors/metabolism ; Transcriptional Activation/genetics
Czasopismo naukowe
Tytuł :
Evaluating the effect of secretome of human amniotic mesenchymal stromal cells on apoptosis induction and epithelial-mesenchymal transition inhibition in LNCaP prostate cancer cells based on 2D and 3D cell culture models.
Autorzy :
Safari F; Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran.
Shakery T; Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran.
Sayadamin N; Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran.
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Źródło :
Cell biochemistry and function [Cell Biochem Funct] 2021 Aug; Vol. 39 (6), pp. 813-820. Date of Electronic Publication: 2021 Jun 14.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Culture Media, Conditioned/*pharmacology
Epithelial-Mesenchymal Transition/*drug effects
Mesenchymal Stem Cells/*drug effects
Snail Family Transcription Factors/*antagonists & inhibitors
Vimentin/*antagonists & inhibitors
Zinc Finger E-box-Binding Homeobox 1/*antagonists & inhibitors
Coculture Techniques ; Culture Media, Conditioned/chemistry ; Down-Regulation/drug effects ; Humans ; Mesenchymal Stem Cells/metabolism ; Snail Family Transcription Factors/metabolism ; Tumor Cells, Cultured ; Vimentin/metabolism ; Zinc Finger E-box-Binding Homeobox 1/metabolism
Czasopismo naukowe
Tytuł :
Loss of polarity protein Par3, via transcription factor Snail, promotes bladder cancer metastasis.
Autorzy :
Wang S; NHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Cai J; Department of Urology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhang S; NHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Dong M; NHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Zhang L; NHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Xu Y; NHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Shen B; Department of Urology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Chen S; NHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Jul; Vol. 112 (7), pp. 2625-2641. Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Cell Cycle Proteins/*metabolism
Glycogen Synthase Kinase 3 beta/*antagonists & inhibitors
Lung Neoplasms/*secondary
Snail Family Transcription Factors/*metabolism
Urinary Bladder Neoplasms/*metabolism
Urinary Bladder Neoplasms/*pathology
Adaptor Proteins, Signal Transducing/deficiency ; Adaptor Proteins, Signal Transducing/genetics ; Animals ; Cell Cycle Proteins/deficiency ; Cell Cycle Proteins/genetics ; Cell Nucleus/metabolism ; Cell Polarity/physiology ; Gene Knockdown Techniques ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Mutation ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplasm Proteins/deficiency ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Phenotype ; Phosphorylation ; Prognosis ; Random Allocation ; Snail Family Transcription Factors/genetics ; Tight Junctions/physiology ; Zonula Occludens-1 Protein/metabolism
Czasopismo naukowe
Tytuł :
The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression.
Autorzy :
Gentile A; Max Planck Institute for Heart and Lung Research, Department of Developmental Genetics, Bad Nauheim, Germany.
Bensimon-Brito A; Max Planck Institute for Heart and Lung Research, Department of Developmental Genetics, Bad Nauheim, Germany.; DZHK German Centre for Cardiovascular Research, Partner Site Rhine-Main, Bad Nauheim, Germany.
Priya R; Max Planck Institute for Heart and Lung Research, Department of Developmental Genetics, Bad Nauheim, Germany.; DZHK German Centre for Cardiovascular Research, Partner Site Rhine-Main, Bad Nauheim, Germany.
Maischein HM; Max Planck Institute for Heart and Lung Research, Department of Developmental Genetics, Bad Nauheim, Germany.
Piesker J; Max Planck Institute for Heart and Lung Research, Microscopy Service Group, Bad Nauheim, Germany.
Guenther S; DZHK German Centre for Cardiovascular Research, Partner Site Rhine-Main, Bad Nauheim, Germany.; Max Planck Institute for Heart and Lung Research, Bioinformatics and Deep Sequencing Platform, Bad Nauheim, Germany.
Gunawan F; Max Planck Institute for Heart and Lung Research, Department of Developmental Genetics, Bad Nauheim, Germany.; DZHK German Centre for Cardiovascular Research, Partner Site Rhine-Main, Bad Nauheim, Germany.
Stainier DY; Max Planck Institute for Heart and Lung Research, Department of Developmental Genetics, Bad Nauheim, Germany.; DZHK German Centre for Cardiovascular Research, Partner Site Rhine-Main, Bad Nauheim, Germany.
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Źródło :
ELife [Elife] 2021 Jun 21; Vol. 10. Date of Electronic Publication: 2021 Jun 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Heart/*physiology
Intermediate Filaments/*genetics
Snail Family Transcription Factors/*genetics
Zebrafish/*physiology
Zebrafish Proteins/*genetics
Animals ; Myocardium/metabolism ; Snail Family Transcription Factors/metabolism ; Zebrafish/genetics ; Zebrafish Proteins/metabolism
Czasopismo naukowe
Tytuł :
Snail1 expression in endothelial cells controls growth, angiogenesis and differentiation of breast tumors.
Autorzy :
Cabrerizo-Granados D; Programa de Recerca en Càncer, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Unidad Asociada al CSIC, Barcelona, Spain.; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.
Peña R; Programa de Recerca en Càncer, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Unidad Asociada al CSIC, Barcelona, Spain.
Palacios L; Programa de Recerca en Càncer, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Unidad Asociada al CSIC, Barcelona, Spain.
Carrillo-Bosch L; Programa de Recerca en Càncer, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Unidad Asociada al CSIC, Barcelona, Spain.
Lloreta-Trull J; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.; Servei d'Anatomia Patològica, Hospital del Mar, Barcelona, Spain.
Comerma L; Servei d'Anatomia Patològica, Hospital del Mar, Barcelona, Spain.
Iglesias M; Servei d'Anatomia Patològica, Hospital del Mar, Barcelona, Spain.
de Herreros AG; Programa de Recerca en Càncer, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Unidad Asociada al CSIC, Barcelona, Spain.; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.
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Źródło :
Theranostics [Theranostics] 2021 Jun 16; Vol. 11 (16), pp. 7671-7684. Date of Electronic Publication: 2021 Jun 16 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*genetics
Snail Family Transcription Factors/*metabolism
Animals ; Breast Neoplasms/metabolism ; Cancer-Associated Fibroblasts/metabolism ; Carcinogenesis/pathology ; Cell Line, Tumor ; Endothelial Cells/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Epithelial-Mesenchymal Transition/physiology ; Female ; Fibroblasts/metabolism ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neovascularization, Pathologic/pathology ; Snail Family Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
STK39 promotes breast cancer invasion and metastasis by increasing SNAI1 activity upon phosphorylation.
Autorzy :
Qiu Z; Department of Pharmacology & Nutritional Sciences, University of Kentucky, College of Medicine, Lexington, KY 40506, United States.; Markey Cancer Center, the University of Kentucky, College of Medicine, Lexington, KY 40506, United States.
Dong B; Department of Pharmacology & Nutritional Sciences, University of Kentucky, College of Medicine, Lexington, KY 40506, United States.; Markey Cancer Center, the University of Kentucky, College of Medicine, Lexington, KY 40506, United States.
Guo W; Markey Cancer Center, the University of Kentucky, College of Medicine, Lexington, KY 40506, United States.
Piotr R; Department of Surgery, University of Kentucky, College of Medicine, Lexington, KY 40506, United States.; Markey Cancer Center, the University of Kentucky, College of Medicine, Lexington, KY 40506, United States.
Longmore G; Department of Medicine (Oncology), Cell Biology and Physiology, Washington University, St. Louis.
Yang X; Department of Pharmacology & Nutritional Sciences, University of Kentucky, College of Medicine, Lexington, KY 40506, United States.
Yu Z; Department of Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Deng J; Key Laboratory of Cell Differentiation and Apoptosis of Chinese Minister of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Evers BM; Department of Surgery, University of Kentucky, College of Medicine, Lexington, KY 40506, United States.; Markey Cancer Center, the University of Kentucky, College of Medicine, Lexington, KY 40506, United States.
Wu Y; Department of Pharmacology & Nutritional Sciences, University of Kentucky, College of Medicine, Lexington, KY 40506, United States.; Markey Cancer Center, the University of Kentucky, College of Medicine, Lexington, KY 40506, United States.
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Źródło :
Theranostics [Theranostics] 2021 Jun 11; Vol. 11 (16), pp. 7658-7670. Date of Electronic Publication: 2021 Jun 11 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Snail Family Transcription Factors/*metabolism
Animals ; Breast Neoplasms/physiopathology ; Cell Line, Tumor ; Cell Movement/genetics ; Epithelial-Mesenchymal Transition/genetics ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Mice ; Mice, SCID ; Neoplasm Invasiveness/genetics ; Phosphorylation ; Protein-Serine-Threonine Kinases/genetics ; Snail Family Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
GTSE1 promotes SNAIL1 degradation by facilitating its nuclear export in hepatocellular carcin oma cells.
Autorzy :
Li SS; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China.
Chen DM; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China.
Chen LB; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China.
Wei H; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China.
Wang JL; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China.
Xiao J; Department of Medical Oncology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510655, P.R. China.
Huang YH; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China.
Lian YF; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Jun; Vol. 23 (6). Date of Electronic Publication: 2021 Apr 21.
Typ publikacji :
Journal Article
MeSH Terms :
Active Transport, Cell Nucleus/*physiology
Carcinoma, Hepatocellular/*metabolism
Liver Neoplasms/*metabolism
Microtubule-Associated Proteins/*metabolism
Snail Family Transcription Factors/*metabolism
Active Transport, Cell Nucleus/genetics ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Cycle ; Cell Line, Tumor ; Cell Proliferation ; Down-Regulation ; Gene Expression Regulation, Neoplastic ; HEK293 Cells ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Microtubule-Associated Proteins/genetics ; Neoplasm Recurrence, Local/genetics ; Promoter Regions, Genetic ; Proteasome Endopeptidase Complex ; Signal Transduction ; Snail Family Transcription Factors/genetics ; Up-Regulation
Czasopismo naukowe
Tytuł :
Stabilization of snail maintains the sorafenib resistance of hepatocellular carcinoma cells.
Autorzy :
Zhao H; Department of General Surgery, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, 200438, China. Electronic address: .
Cheng X; Department of Radiotherapy, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, 200438, China. Electronic address: .
Yu J; Department of General Surgery, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, 200438, China. Electronic address: .
Li Y; Department of Radiotherapy, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, 200438, China. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Mar 15; Vol. 699, pp. 108754. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular/*physiopathology
Drug Resistance, Neoplasm/*physiology
Liver Neoplasms/*physiopathology
Snail Family Transcription Factors/*metabolism
Sorafenib/*pharmacology
Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; COP9 Signalosome Complex/genetics ; COP9 Signalosome Complex/metabolism ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition/physiology ; Gene Silencing ; Humans ; Protein Stability ; RNA, Small Interfering/pharmacology ; Snail Family Transcription Factors/chemistry ; Snail Family Transcription Factors/genetics ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium.
Autorzy :
Carter LE; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
Cook DP; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
McCloskey CW; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
Grondin MA; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
Landry DA; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
Dang T; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
Collins O; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
Gamwell LF; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
Dempster HA; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
Vanderhyden BC; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. .; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada. .
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Źródło :
Communications biology [Commun Biol] 2021 May 05; Vol. 4 (1), pp. 527. Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Phenotype*
BRCA1 Protein/*metabolism
Epithelial Cells/*cytology
Ovary/*cytology
Snail Family Transcription Factors/*metabolism
Stem Cells/*cytology
Transforming Growth Factor beta1/*metabolism
BRCA1 Protein/genetics ; Epithelial Cells/metabolism ; Epithelial-Mesenchymal Transition ; Female ; Gene Expression Profiling ; Gene Expression Regulation ; Humans ; Ovary/metabolism ; Signal Transduction ; Snail Family Transcription Factors/genetics ; Stem Cells/metabolism ; Transforming Growth Factor beta1/genetics
Czasopismo naukowe
Tytuł :
EBV-miR-BART12 inhibits cell migration and proliferation by targeting Snail expression in EBV-associated gastric cancer.
Autorzy :
Li J; Department of Pathogenic Biology, Qingdao University Medical College, 2 Ningde Road, Qingdao, 266000, China.
Zhang Y; Department of Clinical Laboratory, Zibo Central Hospital, 54 Gongqingtuan Road, Zibo, 255036, China.
Liu J; Department of Pathogenic Biology, Qingdao University Medical College, 2 Ningde Road, Qingdao, 266000, China.
Shi Q; Department of Pathogenic Biology, Qingdao University Medical College, 2 Ningde Road, Qingdao, 266000, China.
Liu W; Department of Pathogenic Biology, Qingdao University Medical College, 2 Ningde Road, Qingdao, 266000, China.
Luo B; Department of Pathogenic Biology, Qingdao University Medical College, 2 Ningde Road, Qingdao, 266000, China. .
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Źródło :
Archives of virology [Arch Virol] 2021 May; Vol. 166 (5), pp. 1313-1323. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article
MeSH Terms :
Epstein-Barr Virus Infections/*pathology
Herpesvirus 4, Human/*physiology
MicroRNAs/*metabolism
RNA, Viral/*metabolism
Snail Family Transcription Factors/*metabolism
Stomach Neoplasms/*pathology
Apoptosis ; Cell Cycle ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Epithelial-Mesenchymal Transition/genetics ; Epstein-Barr Virus Infections/genetics ; Epstein-Barr Virus Infections/metabolism ; Epstein-Barr Virus Infections/virology ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; NF-kappa B/genetics ; NF-kappa B/metabolism ; RNA, Viral/genetics ; Signal Transduction ; Snail Family Transcription Factors/genetics ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/virology
Czasopismo naukowe
Tytuł :
Resveratrol induces PD-L1 expression through snail-driven activation of Wnt pathway in lung cancer cells.
Autorzy :
Yang M; School of Anesthesiology, Wannan Medical College, Wuhu, 241001, China.; Research Laboratory of Tumor Microenvironment, Wannan Medical College, Wuhu, 241001, China.; Anhui Province Key Laboratory of Active Biological Macro-Molecules Research, Wannan Medical College, Wuhu, 241001, China.
Li Z; Research Laboratory of Tumor Microenvironment, Wannan Medical College, Wuhu, 241001, China.; Anhui Province Key Laboratory of Active Biological Macro-Molecules Research, Wannan Medical College, Wuhu, 241001, China.; School of Medical Imageology, Wannan Medical College, Wuhu, 241001, China.
Tao J; Research Laboratory of Tumor Microenvironment, Wannan Medical College, Wuhu, 241001, China.; School of Clinical Medicine, Wannan Medical College, Wuhu, 241001, China.
Hu H; Research Laboratory of Tumor Microenvironment, Wannan Medical College, Wuhu, 241001, China.; School of Clinical Medicine, Wannan Medical College, Wuhu, 241001, China.
Li Z; Research Laboratory of Tumor Microenvironment, Wannan Medical College, Wuhu, 241001, China.; School of Medical Imageology, Wannan Medical College, Wuhu, 241001, China.
Zhang Z; Research Laboratory of Tumor Microenvironment, Wannan Medical College, Wuhu, 241001, China.; School of Preclinical Medicine, Wannan Medical College, Wuhu, 241001, China.
Cheng F; Research Laboratory of Tumor Microenvironment, Wannan Medical College, Wuhu, 241001, China.; Anhui Province Key Laboratory of Active Biological Macro-Molecules Research, Wannan Medical College, Wuhu, 241001, China.
Sun Y; Research Laboratory of Tumor Microenvironment, Wannan Medical College, Wuhu, 241001, China.; School of Clinical Medicine, Wannan Medical College, Wuhu, 241001, China.
Zhang Y; Anhui Province Key Laboratory of Active Biological Macro-Molecules Research, Wannan Medical College, Wuhu, 241001, China.
Yang J; Research Laboratory of Tumor Microenvironment, Wannan Medical College, Wuhu, 241001, China.; School of Preclinical Medicine, Wannan Medical College, Wuhu, 241001, China.
Wei H; Anhui Province Key Laboratory of Active Biological Macro-Molecules Research, Wannan Medical College, Wuhu, 241001, China.
Wu Z; Research Laboratory of Tumor Microenvironment, Wannan Medical College, Wuhu, 241001, China. .; Anhui Province Key Laboratory of Active Biological Macro-Molecules Research, Wannan Medical College, Wuhu, 241001, China. .; School of Preclinical Medicine, Wannan Medical College, Wuhu, 241001, China. .
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Apr; Vol. 147 (4), pp. 1101-1113. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :
Journal Article
MeSH Terms :
B7-H1 Antigen/*metabolism
Gene Expression Regulation, Neoplastic/*drug effects
Lung Neoplasms/*drug therapy
Resveratrol/*pharmacology
Snail Family Transcription Factors/*metabolism
Wnt Proteins/*metabolism
beta Catenin/*metabolism
Antioxidants/pharmacology ; Apoptosis ; B7-H1 Antigen/genetics ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Proliferation ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Snail Family Transcription Factors/genetics ; Tumor Cells, Cultured ; Wnt Proteins/genetics ; beta Catenin/genetics
Czasopismo naukowe
Tytuł :
Skp2 and Slug Are Coexpressed in Aggressive Prostate Cancer and Inhibited by Neddylation Blockade.
Autorzy :
Mickova A; Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, 779 00 Olomouc, Czech Republic.; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic.
Kharaishvili G; Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, 779 00 Olomouc, Czech Republic.
Kurfurstova D; Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, 779 00 Olomouc, Czech Republic.
Gachechiladze M; Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, 779 00 Olomouc, Czech Republic.; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic.
Kral M; Department of Urology, University Hospital, 779 00 Olomouc, Czech Republic.
Vacek O; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.; International Clinical Research Center, Center for Biomolecular and Cellular Engineering, St. Anne's University Hospital in Brno, 602 00 Brno, Czech Republic.; Department of Experimental Biology, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic.
Pokryvkova B; Department of Genetics and Microbiology, Faculty of Science, Charles University, BIOCEV, 252 50 Vestec, Czech Republic.
Mistrik M; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic.
Soucek K; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.; International Clinical Research Center, Center for Biomolecular and Cellular Engineering, St. Anne's University Hospital in Brno, 602 00 Brno, Czech Republic.; Department of Experimental Biology, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic.
Bouchal J; Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, 779 00 Olomouc, Czech Republic.; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 11; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Processing, Post-Translational*
NEDD8 Protein/*genetics
Prostatic Neoplasms/*genetics
S-Phase Kinase-Associated Proteins/*genetics
Snail Family Transcription Factors/*genetics
Antigens, CD/genetics ; Antigens, CD/metabolism ; Antineoplastic Agents/pharmacology ; Cadherins/genetics ; Cadherins/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Cyclin-Dependent Kinase Inhibitor p27/genetics ; Cyclin-Dependent Kinase Inhibitor p27/metabolism ; Cyclopentanes/pharmacology ; Docetaxel/pharmacology ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Lymphatic Metastasis ; Male ; NEDD8 Protein/metabolism ; Neoplasm Grading ; PC-3 Cells ; Prostate/metabolism ; Prostate/pathology ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Pyrimidines/pharmacology ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism ; S-Phase Kinase-Associated Proteins/antagonists & inhibitors ; S-Phase Kinase-Associated Proteins/metabolism ; Snail Family Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
KLF4, Slug and EMT in Head and Neck Squamous Cell Carcinoma.
Autorzy :
Ingruber J; Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Innsbruck, University Hospital of Tyrol, A-6020 Innsbruck, Austria.
Savic D; Laboratory for Experimental and Translational Research on Radiation Oncology (EXTRO-Lab), Department of Therapeutic Radiology and Oncology, Medical University of Innsbruck, A-6020 Innsbruck, Austria.; Tyrolean Cancer Research Institute, A-6020 Innsbruck, Austria.
Steinbichler TB; Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Innsbruck, University Hospital of Tyrol, A-6020 Innsbruck, Austria.
Sprung S; Department of Pathology, Medical University of Innsbruck, A-6020 Innsbruck, Austria.
Fleischer F; Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Innsbruck, University Hospital of Tyrol, A-6020 Innsbruck, Austria.; Department of Restorative and Operative Dentistry, Medical University of Innsbruck, A-6020 Innsbruck, Austria.
Glueckert R; Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Innsbruck, University Hospital of Tyrol, A-6020 Innsbruck, Austria.
Schweigl G; Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Innsbruck, University Hospital of Tyrol, A-6020 Innsbruck, Austria.
Skvortsova II; Laboratory for Experimental and Translational Research on Radiation Oncology (EXTRO-Lab), Department of Therapeutic Radiology and Oncology, Medical University of Innsbruck, A-6020 Innsbruck, Austria.; Tyrolean Cancer Research Institute, A-6020 Innsbruck, Austria.
Riechelmann H; Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Innsbruck, University Hospital of Tyrol, A-6020 Innsbruck, Austria.
Dudás J; Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Innsbruck, University Hospital of Tyrol, A-6020 Innsbruck, Austria.
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Źródło :
Cells [Cells] 2021 Mar 03; Vol. 10 (3). Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Head and Neck Neoplasms/*genetics
Kruppel-Like Transcription Factors/*genetics
Nuclear Proteins/*genetics
Snail Family Transcription Factors/*genetics
Squamous Cell Carcinoma of Head and Neck/*genetics
Tumor Suppressor Protein p53/*genetics
Twist-Related Protein 1/*genetics
Aged ; Aged, 80 and over ; Case-Control Studies ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Epithelial-Mesenchymal Transition/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/mortality ; Head and Neck Neoplasms/pathology ; Humans ; Kruppel-Like Transcription Factors/metabolism ; Male ; Middle Aged ; Neoplasm Staging ; Nuclear Proteins/metabolism ; Signal Transduction ; Snail Family Transcription Factors/metabolism ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Squamous Cell Carcinoma of Head and Neck/mortality ; Squamous Cell Carcinoma of Head and Neck/pathology ; Survival Analysis ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta1/metabolism ; Tumor Suppressor Protein p53/metabolism ; Twist-Related Protein 1/metabolism ; Vimentin/genetics ; Vimentin/metabolism ; Zinc Finger E-box-Binding Homeobox 1/genetics ; Zinc Finger E-box-Binding Homeobox 1/metabolism
Czasopismo naukowe
Tytuł :
The miR-5694/AF9/Snail Axis Provides Metastatic Advantages and a Therapeutic Target in Basal-like Breast Cancer.
Autorzy :
Tian X; Cancer Research Institute, The First Affiliated Hospital of China Medical University, Shenyang, China; Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou 510006, China. Electronic address: .
Yu H; CAS Key Laboratory of Tissue Microenvironment and Tumor, Institute of Health Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou 510006, China.
Li D; International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, The China Welfare Institute, Shanghai 200030, China.
Jin G; Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.
Dai S; Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China.
Gong P; Cancer Research Institute, The First Affiliated Hospital of China Medical University, Shenyang, China.
Kong C; Cancer Research Institute, The First Affiliated Hospital of China Medical University, Shenyang, China.
Wang X; CAS Key Laboratory of Tissue Microenvironment and Tumor, Institute of Health Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou 510006, China. Electronic address: .
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Źródło :
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2021 Mar 03; Vol. 29 (3), pp. 1239-1257. Date of Electronic Publication: 2020 Nov 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial-Mesenchymal Transition*
Breast Neoplasms/*pathology
Carcinoma, Basal Cell/*pathology
Lung Neoplasms/*secondary
MicroRNAs/*genetics
Nuclear Proteins/*metabolism
Snail Family Transcription Factors/*metabolism
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Carcinoma, Basal Cell/genetics ; Carcinoma, Basal Cell/metabolism ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Invasiveness ; Nuclear Proteins/genetics ; Prognosis ; RNA, Small Interfering/genetics ; Snail Family Transcription Factors/genetics ; Survival Rate ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
miR-34a-5p might have an important role for inducing apoptosis by down-regulation of SNAI1 in apigenin-treated lung cancer cells.
Autorzy :
Aida R; Faculty of Biomedical Engineering, Toin University of Yokohama, 1614 Kurogane-cho, Aoba-ku, Yokohama, 225-8503, Japan.
Hagiwara K; Faculty of Biomedical Engineering, Toin University of Yokohama, 1614 Kurogane-cho, Aoba-ku, Yokohama, 225-8503, Japan.
Okano K; Division of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan.
Nakata K; Faculty of Biomedical Engineering, Toin University of Yokohama, 1614 Kurogane-cho, Aoba-ku, Yokohama, 225-8503, Japan.
Obata Y; Faculty of Biomedical Engineering, Toin University of Yokohama, 1614 Kurogane-cho, Aoba-ku, Yokohama, 225-8503, Japan.
Yamashita T; Faculty of Biomedical Engineering, Toin University of Yokohama, 1614 Kurogane-cho, Aoba-ku, Yokohama, 225-8503, Japan.
Yoshida K; Faculty of Biomedical Engineering, Toin University of Yokohama, 1614 Kurogane-cho, Aoba-ku, Yokohama, 225-8503, Japan.
Hagiwara H; Faculty of Biomedical Engineering, Toin University of Yokohama, 1614 Kurogane-cho, Aoba-ku, Yokohama, 225-8503, Japan. .
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Źródło :
Molecular biology reports [Mol Biol Rep] 2021 Mar; Vol. 48 (3), pp. 2291-2297. Date of Electronic Publication: 2021 Mar 06.
Typ publikacji :
Journal Article
MeSH Terms :
Apigenin/*pharmacology
Apoptosis/*genetics
Down-Regulation/*genetics
Lung Neoplasms/*genetics
Lung Neoplasms/*pathology
MicroRNAs/*metabolism
Snail Family Transcription Factors/*genetics
A549 Cells ; Apoptosis/drug effects ; Cell Survival/drug effects ; Cell Survival/genetics ; Down-Regulation/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; MicroRNAs/genetics ; Models, Biological ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Snail Family Transcription Factors/metabolism ; Up-Regulation/drug effects ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
Radiation exposure triggers the malignancy of non‑small cell lung cancer cells through the activation of visfatin/Snail signaling.
Autorzy :
Xiao L; Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
Mao Y; Teaching and Research Section of Nuclear Medicine, Anhui Medical University, Hefei, Anhui 230022, P.R. China.
Tong Z; Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
Zhao Y; Teaching and Research Section of Nuclear Medicine, Anhui Medical University, Hefei, Anhui 230022, P.R. China.
Hong H; Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
Wang F; Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
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Źródło :
Oncology reports [Oncol Rep] 2021 Mar; Vol. 45 (3), pp. 1153-1161. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*radiotherapy
Cytokines/*genetics
Gene Expression Regulation, Neoplastic/*radiation effects
Lung Neoplasms/*radiotherapy
MicroRNAs/*metabolism
Nicotinamide Phosphoribosyltransferase/*genetics
Snail Family Transcription Factors/*genetics
3' Untranslated Regions ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Movement/radiation effects ; Epithelial-Mesenchymal Transition/genetics ; Epithelial-Mesenchymal Transition/radiation effects ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Neoplasm Invasiveness/genetics ; Radiation Exposure/adverse effects ; Signal Transduction/genetics ; Signal Transduction/radiation effects ; Snail Family Transcription Factors/metabolism ; Up-Regulation/radiation effects
Czasopismo naukowe
Tytuł :
Erythrocyte membrane protein band 4.1-like 3 inhibits osteosarcoma cell invasion through regulation of Snai1-induced epithelial-to-mesenchymal transition.
Autorzy :
Yuan X; Department of Orthopedics, The Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu, P.R. China.
Piao L; Institute of Bioinformatics and Medical Engineering, Jiangsu University of Technology, Changzhou 213000, Jiangsu, P.R. China.
Wang L; Department of Orthopedics, The Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu, P.R. China.
Han X; Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu, P.R. China.
Tong L; Department of Orthopedics, The Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu, P.R. China.
Shao S; Department of Orthopedics, The Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu, P.R. China.
Xu X; Institute of Bioinformatics and Medical Engineering, Jiangsu University of Technology, Changzhou 213000, Jiangsu, P.R. China.
Zhuang M; Department of Orthopedics, The Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu, P.R. China.
Liu Z; Department of Orthopedics, The Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu, P.R. China.
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Źródło :
Aging [Aging (Albany NY)] 2020 Dec 11; Vol. 13 (2), pp. 1947-1961. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bone Neoplasms/*genetics
Epithelial-Mesenchymal Transition/*genetics
Microfilament Proteins/*genetics
Osteosarcoma/*genetics
Snail Family Transcription Factors/*biosynthesis
Biomarkers/analysis ; Bone Neoplasms/mortality ; Cadherins/biosynthesis ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Kaplan-Meier Estimate ; Neoplasm Invasiveness/genetics ; Neoplasm Metastasis/genetics ; Neoplasm Metastasis/pathology ; Osteosarcoma/mortality ; Snail Family Transcription Factors/antagonists & inhibitors ; Snail Family Transcription Factors/genetics ; Tumor Stem Cell Assay ; Vimentin/biosynthesis
Czasopismo naukowe
Tytuł :
SNAIL regulates gastric carcinogenesis through CCN3 and NEFL.
Autorzy :
Chen R; DSK Project, Medical Innovation Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Masuo K; DSK Project, Medical Innovation Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yogo A; DSK Project, Medical Innovation Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yokoyama S; DSK Project, Medical Innovation Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sugiyama A; DSK Project, Medical Innovation Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Seno H; DSK Project, Medical Innovation Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yoshizawa A; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Takaishi S; DSK Project, Medical Innovation Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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Źródło :
Carcinogenesis [Carcinogenesis] 2021 Feb 25; Vol. 42 (2), pp. 190-201.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinogenesis/*genetics
Nephroblastoma Overexpressed Protein/*genetics
Neurofilament Proteins/*genetics
Snail Family Transcription Factors/*metabolism
Stomach Neoplasms/*genetics
Animals ; Cell Line, Tumor ; Cell Proliferation ; Down-Regulation ; Drug Resistance, Neoplasm/genetics ; Epithelial-Mesenchymal Transition/genetics ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Mice ; Neoplastic Stem Cells/pathology ; Nephroblastoma Overexpressed Protein/metabolism ; Neurofilament Proteins/metabolism ; Signal Transduction/genetics ; Snail Family Transcription Factors/genetics ; Stomach/pathology ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology ; Up-Regulation ; Xenograft Model Antitumor Assays
Czasopismo naukowe

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