- Tytuł:
- A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
- Autorzy:
- Źródło:
- Nature chemical biology [Nat Chem Biol] 2012 Nov; Vol. 8 (11), pp. 890-6. Date of Electronic Publication: 2012 Sep 30.
- Typ publikacji:
- Journal Article
- MeSH Terms:
-
Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Histones/*metabolism
Indazoles/*pharmacology
Lymphoma/*drug therapy
Lymphoma/*pathology
Polycomb Repressive Complex 2/*antagonists & inhibitors
Pyridones/*pharmacology
Antineoplastic Agents/chemistry ; Cell Cycle/drug effects ; Cell Death/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Enhancer of Zeste Homolog 2 Protein ; Enzyme Inhibitors/chemistry ; Histones/chemistry ; Humans ; Indazoles/chemistry ; Lymphoma/enzymology ; Lymphoma/genetics ; Lysine/metabolism ; Methylation/drug effects ; Molecular Structure ; Point Mutation ; Polycomb Repressive Complex 2/genetics ; Polycomb Repressive Complex 2/metabolism ; Pyridones/chemistry ; Structure-Activity Relationship
Czasopismo naukowe