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Wyszukujesz frazę ""Snyder NW"" wg kryterium: Autor


Tytuł:
Lactoylglutathione promotes inflammatory signaling in macrophages through histone lactoylation.
Autorzy:
Trujillo MN; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA.
Jennings EQ; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA.
Hoffman EA; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA.
Zhang H; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA.
Phoebe AM; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA.
Mastin GE; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA.
Kitamura N; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA.
Reisz JA; Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO 80045, USA.
Megill E; Center for Metabolic Disease Research, Department of Cardiovascular Sciences, Temple University, Philadelphia, PA, USA.
Kantner D; Center for Metabolic Disease Research, Department of Cardiovascular Sciences, Temple University, Philadelphia, PA, USA.
Marcinkiewicz MM; Center for Metabolic Disease Research, Department of Cardiovascular Sciences, Temple University, Philadelphia, PA, USA.
Twardy SM; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Lebario F; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA.
Chapman E; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA.
McCullough RL; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO 80045, USA.
Snyder NW; Center for Metabolic Disease Research, Department of Cardiovascular Sciences, Temple University, Philadelphia, PA, USA.
Cusanovich DA; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA; Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA.
Galligan JJ; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA. Electronic address: .
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Źródło:
Molecular metabolism [Mol Metab] 2024 Mar; Vol. 81, pp. 101888. Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Histones*/metabolism
Lactoylglutathione Lyase*/metabolism
Chromatin/metabolism ; Glycolysis ; Lactic Acid/metabolism ; Macrophages/metabolism
Czasopismo naukowe
Tytuł:
Comparison of colorimetric, fluorometric, and liquid chromatography-mass spectrometry assays for acetyl-coenzyme A.
Autorzy:
Kantner DS; Lewis Katz School of Medicine at Temple University, Department of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Philadelphia, PA, 19140, USA.
Megill E; Lewis Katz School of Medicine at Temple University, Department of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Philadelphia, PA, 19140, USA.
Bostwick A; Lewis Katz School of Medicine at Temple University, Department of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Philadelphia, PA, 19140, USA.
Yang V; Lewis Katz School of Medicine at Temple University, Department of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Philadelphia, PA, 19140, USA.
Bekeova C; MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Van Scoyk A; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA.
Seifert EL; MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Deininger MW; Versiti Blood Research Institute and Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Snyder NW; Lewis Katz School of Medicine at Temple University, Department of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Philadelphia, PA, 19140, USA. Electronic address: .
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Źródło:
Analytical biochemistry [Anal Biochem] 2024 Jan 15; Vol. 685, pp. 115405. Date of Electronic Publication: 2023 Nov 26.
Typ publikacji:
Journal Article
MeSH Terms:
Colorimetry*
Humans ; Acetyl Coenzyme A/metabolism ; Chromatography, Liquid/methods ; Tandem Mass Spectrometry/methods
Czasopismo naukowe
Tytuł:
Dietary branched-chain amino acids get to the heart of H3K23Pr.
Autorzy:
Demetriadou C; Department of Cancer Biology and.; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
Kantner DS; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
Snyder NW; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
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Źródło:
The Journal of clinical investigation [J Clin Invest] 2023 Nov 15; Vol. 133 (22). Date of Electronic Publication: 2023 Nov 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Comment
MeSH Terms:
Amino Acids, Branched-Chain*/metabolism
Heart Failure*/metabolism
Mice ; Animals ; Heart ; Diet ; Signal Transduction
Czasopismo naukowe
Tytuł:
Identification of methylation-regulated genes modulating microglial phagocytosis in hyperhomocysteinemia-exacerbated Alzheimer's disease.
Autorzy:
Wang X; Center for Metabolic Disease Research, Department of Cardiovascular Science, Lewis Kats School of Medicine, Temple University, MERB, Room 1060, 3500 N. Broad Street, Philadelphia, USA.
Liu L; Center for Metabolic Disease Research, Department of Cardiovascular Science, Lewis Kats School of Medicine, Temple University, MERB, Room 1060, 3500 N. Broad Street, Philadelphia, USA.
Jiang X; Center for Metabolic Disease Research, Department of Cardiovascular Science, Lewis Kats School of Medicine, Temple University, MERB, Room 1060, 3500 N. Broad Street, Philadelphia, USA.
Saredy J; Center for Metabolic Disease Research, Department of Cardiovascular Science, Lewis Kats School of Medicine, Temple University, MERB, Room 1060, 3500 N. Broad Street, Philadelphia, USA.
Xi H; Center for Metabolic Disease Research, Department of Cardiovascular Science, Lewis Kats School of Medicine, Temple University, MERB, Room 1060, 3500 N. Broad Street, Philadelphia, USA.
Cueto R; Center for Metabolic Disease Research, Department of Cardiovascular Science, Lewis Kats School of Medicine, Temple University, MERB, Room 1060, 3500 N. Broad Street, Philadelphia, USA.
Sigler D; Center for Metabolic Disease Research, Department of Cardiovascular Science, Lewis Kats School of Medicine, Temple University, MERB, Room 1060, 3500 N. Broad Street, Philadelphia, USA.
Khan M; Center for Metabolic Disease Research, Department of Cardiovascular Science, Lewis Kats School of Medicine, Temple University, MERB, Room 1060, 3500 N. Broad Street, Philadelphia, USA.
Wu S; Center for Metabolic Disease Research, Department of Cardiovascular Science, Lewis Kats School of Medicine, Temple University, MERB, Room 1060, 3500 N. Broad Street, Philadelphia, USA.
Ji Y; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.
Snyder NW; Center for Metabolic Disease Research, Department of Cardiovascular Science, Lewis Kats School of Medicine, Temple University, MERB, Room 1060, 3500 N. Broad Street, Philadelphia, USA.
Hu W; Center for Metabolic Disease Research, Department of Cardiovascular Science, Lewis Kats School of Medicine, Temple University, MERB, Room 1060, 3500 N. Broad Street, Philadelphia, USA.
Yang X; Center for Metabolic Disease Research, Department of Cardiovascular Science, Lewis Kats School of Medicine, Temple University, MERB, Room 1060, 3500 N. Broad Street, Philadelphia, USA.
Wang H; Center for Metabolic Disease Research, Department of Cardiovascular Science, Lewis Kats School of Medicine, Temple University, MERB, Room 1060, 3500 N. Broad Street, Philadelphia, USA. .
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2023 Oct 03; Vol. 15 (1), pp. 164. Date of Electronic Publication: 2023 Oct 03.
Typ publikacji:
Meta-Analysis; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Alzheimer Disease*/metabolism
Hyperhomocysteinemia*/complications
Hyperhomocysteinemia*/genetics
Hyperhomocysteinemia*/metabolism
Mice ; Animals ; Humans ; Amyloid beta-Peptides/metabolism ; Microglia/metabolism ; Methylation ; Phagocytosis ; Disease Models, Animal ; Mice, Transgenic
Czasopismo naukowe
Tytuł:
ER stress mediates Angiotensin II-augmented innate immunity memory and facilitates distinct susceptibilities of thoracic from abdominal aorta to aneurysm development.
Autorzy:
Lu Y; Centers of Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Sun Y; Centers of Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Saaoud F; Centers of Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Shao Y; Centers of Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Xu K; Centers of Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Jiang X; Centers of Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.; Metabolic Disease Research and Thrombosis Research Center, Departments of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Wu S; Metabolic Disease Research and Thrombosis Research Center, Departments of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Yu J; Metabolic Disease Research and Thrombosis Research Center, Departments of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Snyder NW; Metabolic Disease Research and Thrombosis Research Center, Departments of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Yang L; Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Shi XM; Department of Computer and Information Sciences, College of Science and Technology, Temple University, Philadelphia, PA, United States.
Zhao H; Biomedical Education and Data Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Wang H; Metabolic Disease Research and Thrombosis Research Center, Departments of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Yang X; Centers of Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.; Metabolic Disease Research and Thrombosis Research Center, Departments of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
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Źródło:
Frontiers in immunology [Front Immunol] 2023 Sep 04; Vol. 14, pp. 1268916. Date of Electronic Publication: 2023 Sep 04 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Aorta, Abdominal*
Aneurysm*
Humans ; Angiotensin II/pharmacology ; Disease Susceptibility ; Immunity, Innate ; Protein Serine-Threonine Kinases
Czasopismo naukowe
Tytuł:
Chemoproteomics Yields a Selective Molecular Host for Acetyl-CoA.
Autorzy:
Lieberman WK; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States.
Brown ZA; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States.
Kantner DS; Department of Cardiovascular Sciences, Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania 19140, United States.
Jing Y; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States.
Megill E; Department of Cardiovascular Sciences, Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania 19140, United States.
Evans ND; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States.
Crawford MC; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States.
Jhulki I; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States.
Grose C; Protein Expression Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland 21702, United States.
Jones JE; Protein Expression Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland 21702, United States.
Snyder NW; Department of Cardiovascular Sciences, Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania 19140, United States.
Meier JL; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States.
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Źródło:
Journal of the American Chemical Society [J Am Chem Soc] 2023 Aug 02; Vol. 145 (30), pp. 16899-16905. Date of Electronic Publication: 2023 Jul 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms:
Proteome*
Humans ; Acetyl Coenzyme A/chemistry ; Ligands
Czasopismo naukowe
Tytuł:
Acetate controls endothelial-to-mesenchymal transition.
Autorzy:
Zhu X; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Wang Y; MOE Laboratory of Biosystems Homeostasis & Protection of College of Life Sciences, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province of Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Soaita I; Department of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lee HW; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Bae H; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA.
Boutagy N; Vascular Biology and Therapeutics Program and Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
Bostwick A; Center for Metabolic Disease Research, Department of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Zhang RM; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Bowman C; Department of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Xu Y; Department of Geriatric Medicine, Coronary Circulation Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Trefely S; Epigenetics and Signaling Program, Babraham Institute, Cambridge, UK.
Chen Y; MOE Laboratory of Biosystems Homeostasis & Protection of College of Life Sciences, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province of Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Qin L; Vascular Biology and Therapeutics Program and Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
Sessa W; Vascular Biology and Therapeutics Program and Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
Tellides G; Vascular Biology and Therapeutics Program and Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
Jang C; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA.
Snyder NW; Center for Metabolic Disease Research, Department of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Yu L; MOE Laboratory of Biosystems Homeostasis & Protection of College of Life Sciences, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province of Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address: .
Arany Z; Department of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: .
Simons M; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA. Electronic address: .
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Źródło:
Cell metabolism [Cell Metab] 2023 Jul 11; Vol. 35 (7), pp. 1163-1178.e10. Date of Electronic Publication: 2023 Jun 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Endothelial Cells*/metabolism
Vascular Diseases*/metabolism
Humans ; Signal Transduction ; Endothelium/metabolism ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł:
Acyl-CoA thioesterase 12 suppresses YAP-mediated hepatocarcinogenesis by limiting glycerolipid biosynthesis.
Autorzy:
He H; Division of Gastroenterology and Hepatology, Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, 10021, USA; Department of Gastroenterology, Xiangya Hospital of Central South University, Hunan, China.
Sugiyama A; Division of Gastroenterology and Hepatology, Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, 10021, USA; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Snyder NW; Center for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19104, USA.
Teneche MG; Center for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19104, USA.
Liu X; Department of Gastroenterology, Xiangya Hospital of Central South University, Hunan, China.
Maner-Smith KM; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Goessling W; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA; Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA, 02115, USA.
Hagen SJ; Division of Surgical Sciences, Department of Surgery, Beth Israel-Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Ortlund EA; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Najafi-Shoushtari SH; Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, 10021, USA; Research Department, Weill Cornell Medicine-Qatar, Education City, Doha, Qatar.
Acuña M; Division of Gastroenterology and Hepatology, Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, 10021, USA; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. Electronic address: .
Cohen DE; Division of Gastroenterology and Hepatology, Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, 10021, USA; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA, 02115, USA. Electronic address: .
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Źródło:
Cancer letters [Cancer Lett] 2023 Jul 01; Vol. 565, pp. 216210. Date of Electronic Publication: 2023 May 05.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/pathology
Animals ; Mice ; Hippo Signaling Pathway ; Transcription Factors/genetics ; YAP-Signaling Proteins/metabolism
Czasopismo naukowe
Tytuł:
Dynamic protein deacetylation is a limited carbon source for acetyl-CoA-dependent metabolism.
Autorzy:
Soaita I; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Megill E; Center for Metabolic Disease Research, Lewis Katz School of Medicine, TempleUniversity, Philadelphia, Pennsylvania, USA.
Kantner D; Center for Metabolic Disease Research, Lewis Katz School of Medicine, TempleUniversity, Philadelphia, Pennsylvania, USA.
Chatoff A; Center for Metabolic Disease Research, Lewis Katz School of Medicine, TempleUniversity, Philadelphia, Pennsylvania, USA.
Cheong YJ; Epigenetics and Signalling Programs, Babraham Institute, Cambridge, UK.
Clarke P; Epigenetics and Signalling Programs, Babraham Institute, Cambridge, UK.
Arany Z; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: .
Snyder NW; Center for Metabolic Disease Research, Lewis Katz School of Medicine, TempleUniversity, Philadelphia, Pennsylvania, USA. Electronic address: .
Wellen KE; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: .
Trefely S; Epigenetics and Signalling Programs, Babraham Institute, Cambridge, UK. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Jun; Vol. 299 (6), pp. 104772. Date of Electronic Publication: 2023 May 02.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetyl Coenzyme A*/metabolism
Carbon*/metabolism
Histones*/metabolism
Animals ; Mice ; Acetates/metabolism ; Acetylation ; Fibroblasts/metabolism ; Cells, Cultured
Czasopismo naukowe
Tytuł:
Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis.
Autorzy:
Izzo LT; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Trefely S; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.; Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Demetriadou C; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.; Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Drummond JM; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mizukami T; Department of Cancer Epigenetics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Kuprasertkul N; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Farria AT; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Nguyen PTT; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Murali N; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Reich L; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kantner DS; Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Shaffer J; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Affronti H; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Carrer A; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Andrews A; Department of Cancer Epigenetics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.; Department of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, NC 28403, USA.
Capell BC; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Snyder NW; Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Wellen KE; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
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Źródło:
Science advances [Sci Adv] 2023 May 03; Vol. 9 (18), pp. eadf0115. Date of Electronic Publication: 2023 May 03.
Typ publikacji:
Journal Article
MeSH Terms:
Lipogenesis*/genetics
Histones*/metabolism
Acetylcarnitine/metabolism ; Acetylation ; Acetyl Coenzyme A/metabolism ; Fatty Acids/metabolism ; Mitochondria/metabolism ; Glucose/metabolism
Czasopismo naukowe
Tytuł:
Lysine catabolism reprograms tumour immunity through histone crotonylation.
Autorzy:
Yuan H; Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Wu X; Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Wu Q; Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Chatoff A; Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Megill E; Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Gao J; Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Huang T; Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Duan T; Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Yang K; Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA.
Jin C; Department and School of Medicine, University of California, San Diego, CA, USA.
Yuan F; Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Wang S; Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Zhao L; Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Zinn PO; Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Abdullah KG; Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Zhao Y; Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Snyder NW; Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Rich JN; Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. .; Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. .
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Źródło:
Nature [Nature] 2023 May; Vol. 617 (7962), pp. 818-826. Date of Electronic Publication: 2023 May 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Histones*/chemistry
Histones*/metabolism
Lysine*/deficiency
Lysine*/metabolism
Protein Processing, Post-Translational*
Neoplasms*/drug therapy
Neoplasms*/immunology
Neoplasms*/metabolism
Neoplasms*/pathology
Chromatin/chemistry ; Chromatin/genetics ; Chromatin/metabolism ; Glutaryl-CoA Dehydrogenase/metabolism ; RNA, Double-Stranded/immunology ; Humans ; Animals ; Mice ; Interferon Type I/immunology
Czasopismo naukowe
Tytuł:
Allosteric role of the citrate synthase homology domain of ATP citrate lyase.
Autorzy:
Wei X; Department of Biochemistry & Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Laboratory, Guangzhou Medical University, Guangzhou, China.
Schultz K; Graduate Group in Biochemistry & Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Pepper HL; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.; Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Megill E; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.; Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Vogt A; Department of Biochemistry & Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Snyder NW; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.; Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Marmorstein R; Department of Biochemistry & Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. .; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. .; Graduate Group in Biochemistry & Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. .
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Źródło:
Nature communications [Nat Commun] 2023 Apr 19; Vol. 14 (1), pp. 2247. Date of Electronic Publication: 2023 Apr 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
ATP Citrate (pro-S)-Lyase*/genetics
ATP Citrate (pro-S)-Lyase*/metabolism
Citrate (si)-Synthase/genetics ; Citrate (si)-Synthase/metabolism ; Acetyl Coenzyme A/metabolism ; Catalysis
Czasopismo naukowe
Tytuł:
Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages.
Autorzy:
Drummer C 4th; Centers of Cardiovascular Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Saaoud F; Centers of Cardiovascular Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Jhala NC; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Cueto R; Metabolic Disease Research and Thrombosis Research Center, Departments of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Sun Y; Centers of Cardiovascular Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Xu K; Centers of Cardiovascular Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Shao Y; Centers of Cardiovascular Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Lu Y; Centers of Cardiovascular Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Shen H; Metabolic Disease Research and Thrombosis Research Center, Departments of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Yang L; Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Zhou Y; Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Temple Health, Philadelphia, PA, United States.
Yu J; Metabolic Disease Research and Thrombosis Research Center, Departments of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Wu S; Metabolic Disease Research and Thrombosis Research Center, Departments of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Snyder NW; Metabolic Disease Research and Thrombosis Research Center, Departments of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Hu W; Metabolic Disease Research and Thrombosis Research Center, Departments of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Zhuo J'; Tulane Hypertension & Renal Center of Excellence, Tulane University School of Medicine, New Orleans, LA, United States.
Zhong Y; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, United States.
Jiang X; Metabolic Disease Research and Thrombosis Research Center, Departments of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Wang H; Metabolic Disease Research and Thrombosis Research Center, Departments of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Yang X; Centers of Cardiovascular Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.; Metabolic Disease Research and Thrombosis Research Center, Departments of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
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Źródło:
Frontiers in immunology [Front Immunol] 2023 Jan 26; Vol. 14, pp. 1113883. Date of Electronic Publication: 2023 Jan 26 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Non-alcoholic Fatty Liver Disease*/pathology
Diabetes Mellitus, Type 2*/metabolism
Mice ; Animals ; Diet, High-Fat/adverse effects ; Caspases/metabolism ; Pyroptosis ; Oxidative Phosphorylation ; Macrophages ; Inflammation/metabolism ; Glycolysis
Czasopismo naukowe
Tytuł:
The helminth derived peptide FhHDM-1 redirects macrophage metabolism towards glutaminolysis to regulate the pro-inflammatory response.
Autorzy:
Quinteros SL; School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia.
von Krusenstiern E; Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.
Snyder NW; Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.
Tanaka A; School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia.
O'Brien B; School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia.
Donnelly S; School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia.
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Źródło:
Frontiers in immunology [Front Immunol] 2023 Jan 25; Vol. 14, pp. 1018076. Date of Electronic Publication: 2023 Jan 25 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Helminth Proteins*
Fasciola hepatica*
Animals ; Mice ; Macrophages ; Peptides/metabolism ; Inflammation
Czasopismo naukowe
Tytuł:
Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways.
Autorzy:
Saaoud F; Centers for Cardiovascular Research and.
Liu L; Metabolic Disease Research and Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Xu K; Centers for Cardiovascular Research and.
Cueto R; Metabolic Disease Research and Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Shao Y; Centers for Cardiovascular Research and.
Lu Y; Centers for Cardiovascular Research and.
Sun Y; Centers for Cardiovascular Research and.
Snyder NW; Metabolic Disease Research and Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Wu S; Metabolic Disease Research and Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Yang L; Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Zhou Y; Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Temple Health, Philadelphia, Pennsylvania, USA.
Williams DL; Department of Surgery, Center of Excellence in Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Li C; Department of Surgery, Center of Excellence in Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Martinez L; DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, USA.
Vazquez-Padron RI; DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, USA.
Zhao H; Center for Biostatistics and Epidemiology, Department of Biomedical Education and Data Science, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Jiang X; Centers for Cardiovascular Research and.; Metabolic Disease Research and Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Wang H; Metabolic Disease Research and Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Yang X; Centers for Cardiovascular Research and.; Metabolic Disease Research and Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
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Źródło:
JCI insight [JCI Insight] 2023 Jan 10; Vol. 8 (1). Date of Electronic Publication: 2023 Jan 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cardiovascular Diseases*/metabolism
Renal Insufficiency, Chronic*/metabolism
Humans ; Mice ; Animals ; Reactive Oxygen Species/metabolism ; Intercellular Adhesion Molecule-1/genetics ; Intercellular Adhesion Molecule-1/metabolism ; Endothelial Cells ; Trained Immunity ; Liver/metabolism ; Inflammation/metabolism ; Aorta
Czasopismo naukowe
Tytuł:
Acetyl-CoA Counteracts the Inhibitory Effect of Antiandrogens on Androgen Receptor Signaling in Prostate Cancer Cells.
Autorzy:
Makhov P; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Fazliyeva R; Cancer Signaling and Epigenetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Tufano A; Urology Unit, Department of Maternal-Child and Urological Sciences, 'Sapienza' University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
Uzzo RG; Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Cai KQ; Histopathology Facility, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Serebriiskii I; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.; Kazan Federal University, 420000 Kazan, Russia.
Snyder NW; Center for Metabolic Disease Research and the Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Andrews AJ; Cancer Signaling and Epigenetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Kolenko VM; Cancer Signaling and Epigenetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
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Źródło:
Cancers [Cancers (Basel)] 2022 Nov 29; Vol. 14 (23). Date of Electronic Publication: 2022 Nov 29.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Maternal androgens and autism spectrum disorder in the MARBLES prospective cohort study.
Autorzy:
Granillo L; Graduate Group in Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.; Department of Public Health Sciences, School of Medicine, University of California, Davis, Davis, CA, USA.
Iosif AM; Department of Public Health Sciences, School of Medicine, University of California, Davis, Davis, CA, USA.; MIND Institute, School of Medicine, University of California, Davis, Sacramento, CA, USA.
Goodrich A; Department of Public Health Sciences, School of Medicine, University of California, Davis, Davis, CA, USA.
Snyder NW; A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA, USA.; Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Schmidt RJ; Department of Public Health Sciences, School of Medicine, University of California, Davis, Davis, CA, USA.; MIND Institute, School of Medicine, University of California, Davis, Sacramento, CA, USA.
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Źródło:
Research in autism spectrum disorders [Res Autism Spectr Disord] 2022 Nov; Vol. 99. Date of Electronic Publication: 2022 Oct 14.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Editorial: Endothelial cells as innate immune cells.
Autorzy:
Lu Y; Centers of Cardiovascular Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Sun Y; Centers of Cardiovascular Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Xu K; Centers of Cardiovascular Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Shao Y; Metabolic Disease Research and Thrombosis Research Center, Department of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Saaoud F; Centers of Cardiovascular Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Snyder NW; Metabolic Disease Research and Thrombosis Research Center, Department of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Yang L; Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Yu J; Metabolic Disease Research and Thrombosis Research Center, Department of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Wu S; Metabolic Disease Research and Thrombosis Research Center, Department of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Hu W; Metabolic Disease Research and Thrombosis Research Center, Department of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Sun J; Center for Translational Medicine, Department of Medicine, Simmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States.
Wang H; Metabolic Disease Research and Thrombosis Research Center, Department of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
Yang X; Centers of Cardiovascular Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.; Metabolic Disease Research and Thrombosis Research Center, Department of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.
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Źródło:
Frontiers in immunology [Front Immunol] 2022 Oct 04; Vol. 13, pp. 1035497. Date of Electronic Publication: 2022 Oct 04 (Print Publication: 2022).
Typ publikacji:
Editorial; Research Support, N.I.H., Extramural
MeSH Terms:
Endothelial Cells*
Immunity, Innate*
Humans ; Inflammation
Raport
Tytuł:
Thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination in genomic DNA, cell death, and interferon-α/β expression.
Autorzy:
Sugitani N; Department of Radiation Oncology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Vendetti FP; Department of Radiation Oncology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Cipriano AJ; Department of Radiation Oncology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Pandya P; Department of Radiation Oncology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Deppas JJ; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
Moiseeva TN; Tallinn University of Technology, Department of Chemistry and Biotechnology, Tallinn, Estonia.
Schamus-Haynes S; Department of Radiation Oncology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Wang Y; Department of Immunology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Palmer D; UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Osmanbeyoglu HU; UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Biomedical Informatics, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Bostwick A; Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Center for Metabolic Disease Research, Philadelphia, PA, USA.
Snyder NW; Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Center for Metabolic Disease Research, Philadelphia, PA, USA.
Gong YN; Department of Immunology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Aird KM; UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Delgoffe GM; Department of Immunology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Beumer JH; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA; UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Division of Hematology-Oncology, UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Bakkenist CJ; Department of Radiation Oncology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2022 Sep 20; Vol. 40 (12), pp. 111371.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
CD8-Positive T-Lymphocytes*/metabolism
CDC2 Protein Kinase*/metabolism
Animals ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Cell Death ; Cell Line, Tumor ; DNA ; DNA Damage ; DNA-Directed DNA Polymerase/metabolism ; Deoxyuridine ; Genomics ; Interferon-alpha/metabolism ; Interferon-beta ; Mice ; Nucleotides/metabolism ; Protein Kinase Inhibitors/pharmacology ; RNA ; Thymidine/pharmacology
Czasopismo naukowe
Tytuł:
UCP2 modulates cardiomyocyte cell cycle activity, acetyl-CoA, and histone acetylation in response to moderate hypoxia.
Autorzy:
Rigaud VO; Center for Metabolic Disease Research (CMDR).
Zarka C; Center for Metabolic Disease Research (CMDR).
Kurian J; Center for Metabolic Disease Research (CMDR).
Harlamova D; Center for Metabolic Disease Research (CMDR).
Elia A; Center for Metabolic Disease Research (CMDR).
Kasatkin N; Center for Metabolic Disease Research (CMDR).
Johnson J; Cardiovascular Research Institute (CVRC), and.
Behanan M; Center for Metabolic Disease Research (CMDR).
Kraus L; Cardiovascular Research Institute (CVRC), and.
Pepper H; Center for Metabolic Disease Research (CMDR).
Snyder NW; Center for Metabolic Disease Research (CMDR).
Mohsin S; Cardiovascular Research Institute (CVRC), and.
Houser SR; Cardiovascular Research Institute (CVRC), and.
Khan M; Center for Metabolic Disease Research (CMDR).; Department of Cardiovascular Sciences, LKSOM, Temple University, Philadelphia, Pennsylvania, USA.
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Źródło:
JCI insight [JCI Insight] 2022 Aug 08; Vol. 7 (15). Date of Electronic Publication: 2022 Aug 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Mitochondrial Proteins*/metabolism
Myocytes, Cardiac*/metabolism
Acetyl Coenzyme A/metabolism ; Acetylation ; Animals ; Cell Cycle ; Histones/metabolism ; Hypoxia/metabolism ; Ion Channels/genetics ; Ion Channels/metabolism ; Mice ; Oxygen/metabolism ; Rats ; Uncoupling Protein 2/genetics ; Uncoupling Protein 2/metabolism
Czasopismo naukowe

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