Temat: "Sodium" - OpacWWW - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Unique electrophysiological property of a novel Nav1.7, Nav1.8, and Nav1.9 sodium channel blocker, ANP-230.
Autorzy:: Kamei T; Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd., Kobe, 650-0047, Japan. Electronic address: .
Kudo T; Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan.
Yamane H; Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd., Kobe, 650-0047, Japan.
Ishibashi F; Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; Platform Technology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan.
Takada Y; Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; Global Corporate Strategy, Sumitomo Pharma Co., Ltd., Tokyo, 104-8356, Japan.
Honda S; Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; Sumika Chemical Analysis Service, Ltd., Osaka, 554-0022, Japan.
Maezawa Y; Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan.
Ikeda K; Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; Platform Technology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan.
Oyamada Y; Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; AlphaNavi Pharma Inc., Osaka, 564-0053, Japan.; Pokaż więcej
Źródło:: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Aug 20; Vol. 721, pp. 150126. Date of Electronic Publication: 2024 May 14.
Typ publikacji:: Journal Article
MeSH Terms:: NAV1.8 Voltage-Gated Sodium Channel*/metabolism
NAV1.8 Voltage-Gated Sodium Channel*/genetics
NAV1.9 Voltage-Gated Sodium Channel*/metabolism
NAV1.9 Voltage-Gated Sodium Channel*/genetics
NAV1.7 Voltage-Gated Sodium Channel*/metabolism
NAV1.7 Voltage-Gated Sodium Channel*/genetics
Sodium Channel Blockers*/pharmacology
Humans ; Animals ; Rats ; HEK293 Cells ; Voltage-Gated Sodium Channel Blockers/pharmacology ; Ganglia, Spinal/metabolism ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/cytology

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Tytuł:: The potential anti-arrhythmic effect of SGLT2 inhibitors.
Autorzy:: Duan HY; Department of Cardiology and Cardiovascular Research Institute, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei, China.; Hubei Key Laboratory of Cardiology, Wuhan, 430060, Hubei, China.
Barajas-Martinez H; Lankenau Institute for Medical Research, Lankenau Heart Institute, Wynnewood, PA, 19096, USA.; Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, 19107, USA.
Antzelevitch C; Lankenau Institute for Medical Research, Lankenau Heart Institute, Wynnewood, PA, 19096, USA.; Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, 19107, USA.
Hu D; Department of Cardiology and Cardiovascular Research Institute, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei, China. .; Hubei Key Laboratory of Cardiology, Wuhan, 430060, Hubei, China. .; Pokaż więcej
Źródło:: Cardiovascular diabetology [Cardiovasc Diabetol] 2024 Jul 15; Vol. 23 (1), pp. 252. Date of Electronic Publication: 2024 Jul 15.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Sodium-Glucose Transporter 2 Inhibitors*/therapeutic use
Sodium-Glucose Transporter 2 Inhibitors*/adverse effects
Diabetes Mellitus, Type 2*/drug therapy
Diabetes Mellitus, Type 2*/diagnosis
Anti-Arrhythmia Agents*/therapeutic use
Anti-Arrhythmia Agents*/adverse effects
Arrhythmias, Cardiac*/drug therapy
Arrhythmias, Cardiac*/physiopathology
Arrhythmias, Cardiac*/prevention & control
Arrhythmias, Cardiac*/metabolism
Humans ; Animals ; Treatment Outcome ; Heart Rate/drug effects ; Autophagy/drug effects ; Sodium-Glucose Transporter 2/metabolism ; Action Potentials/drug effects ; Sodium/metabolism

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Tytuł:: Sodium-glucose cotransporter 1/2 inhibition and risk of neurodegenerative disorders: A Mendelian randomization study.
Autorzy:: Liu J; Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
Shi X; Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
Shao Y; Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.; Pokaż więcej
Źródło:: Brain and behavior [Brain Behav] 2024 Jul; Vol. 14 (7), pp. e3624.
Typ publikacji:: Journal Article
MeSH Terms:: Mendelian Randomization Analysis*
Sodium-Glucose Transporter 2 Inhibitors*/pharmacology
Polymorphism, Single Nucleotide*
Neurodegenerative Diseases*/genetics
Glycated Hemoglobin*/metabolism
Sodium-Glucose Transporter 1*/genetics
Humans ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/genetics ; Sodium-Glucose Transporter 2/genetics ; Sodium-Glucose Transporter 2/metabolism ; Parkinson Disease/genetics ; Parkinson Disease/drug therapy ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/drug therapy ; Alzheimer Disease/genetics ; Alzheimer Disease/drug therapy ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/genetics

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Skocz do pozycji: 4.

Tytuł:: Loss of the alpha subunit distal furin cleavage site blunts ENaC activation following Na restriction.
Autorzy:: Nickerson AJ; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Sheng S; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Cox NA; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Szekely KG; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Marciszyn AL; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lam T; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Chen J; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Gingras S; Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kashlan OB; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kirabo A; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Hughey RP; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ray EC; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kleyman TR; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Pokaż więcej
Źródło:: The Journal of physiology [J Physiol] 2024 Sep; Vol. 602 (17), pp. 4309-4326. Date of Electronic Publication: 2024 Aug 28.
Typ publikacji:: Journal Article
MeSH Terms:: Epithelial Sodium Channels*/metabolism
Epithelial Sodium Channels*/genetics
Furin*/metabolism
Furin*/genetics
Animals ; Mice ; Male ; Sodium/metabolism ; Colon/metabolism ; Mice, Inbred C57BL ; Aldosterone/metabolism ; Diet, Sodium-Restricted

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Tytuł:: Recent advances in small molecule Nav 1.7 inhibitors for cancer pain management.
Autorzy:: Yu X; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Zhao X; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Li L; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Huang Y; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Cui C; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Hu Q; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Xu H; Yangtze River Pharmaceutical (Group) Co., Ltd., 1 South Yangtze River Road, Taizhou City, Jiangsu Province, 225321, China.
Yin B; Yangtze River Pharmaceutical Group Jiangsu Haici Biological Pharmaceutical Co., Ltd., 8 Taizhen Road, Medical New & Hi-tech Industrial Development Zone, Taizhou City, Jiangsu Province, 225321, China.
Chen X; Yangtze River Pharmaceutical Group Jiangsu Haici Biological Pharmaceutical Co., Ltd., 8 Taizhen Road, Medical New & Hi-tech Industrial Development Zone, Taizhou City, Jiangsu Province, 225321, China.
Zhao D; Yangtze River Pharmaceutical Group Jiangsu Haici Biological Pharmaceutical Co., Ltd., 8 Taizhen Road, Medical New & Hi-tech Industrial Development Zone, Taizhou City, Jiangsu Province, 225321, China.
Qiu Y; Yangtze River Pharmaceutical Group Jiangsu Haici Biological Pharmaceutical Co., Ltd., 8 Taizhen Road, Medical New & Hi-tech Industrial Development Zone, Taizhou City, Jiangsu Province, 225321, China.
Hou Y; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. Electronic address: .; Pokaż więcej
Źródło:: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107605. Date of Electronic Publication: 2024 Jun 29.
Typ publikacji:: Journal Article; Review
MeSH Terms:: NAV1.7 Voltage-Gated Sodium Channel*/metabolism
Voltage-Gated Sodium Channel Blockers*/pharmacology
Voltage-Gated Sodium Channel Blockers*/chemistry
Voltage-Gated Sodium Channel Blockers*/therapeutic use
Humans ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Small Molecule Libraries/therapeutic use ; Cancer Pain/drug therapy ; Cancer Pain/metabolism ; Analgesics/chemistry ; Analgesics/pharmacology ; Analgesics/therapeutic use ; Animals ; Structure-Activity Relationship ; Pain Management/methods ; Molecular Structure ; Neoplasms/drug therapy ; Sodium Channel Blockers/pharmacology ; Sodium Channel Blockers/chemistry ; Sodium Channel Blockers/therapeutic use

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Skocz do pozycji: 6.

Tytuł:: Mendelian randomization study of sodium-glucose cotransporter 2 inhibitors in cardiac and renal diseases.
Autorzy:: Chen L; Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Zuo Y; Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
He M; Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Duo L; Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Tang W; Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Pokaż więcej
Źródło:: The Journal of international medical research [J Int Med Res] 2024 Aug; Vol. 52 (8), pp. 3000605241272639.
Typ publikacji:: Journal Article
MeSH Terms:: Mendelian Randomization Analysis*
Sodium-Glucose Transporter 2 Inhibitors*/therapeutic use
Sodium-Glucose Transporter 2 Inhibitors*/adverse effects
Polymorphism, Single Nucleotide*
Genome-Wide Association Study*
Humans ; Nephrotic Syndrome/genetics ; Nephrotic Syndrome/drug therapy ; Kidney Diseases/genetics ; Sodium/urine ; Sodium/blood ; Glomerulonephritis/genetics ; Glomerulonephritis/drug therapy ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/drug therapy ; Heart Diseases/genetics

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Skocz do pozycji: 7.

Tytuł:: Zinc deficiency induces hypertension by paradoxically amplifying salt sensitivity under high salt intake in mice.
Autorzy:: Yamamoto M; Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Nishi-cho 36-1, Yonago, Tottori, 683-8504, Japan.
Takata T; Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Nishi-cho 36-1, Yonago, Tottori, 683-8504, Japan. .
Hanada H; Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Nishi-cho 36-1, Yonago, Tottori, 683-8504, Japan.
Taniguchi S; Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Nishi-cho 36-1, Yonago, Tottori, 683-8504, Japan.
Hamada S; Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Nishi-cho 36-1, Yonago, Tottori, 683-8504, Japan.
Mae Y; Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Nishi-cho 36-1, Yonago, Tottori, 683-8504, Japan.
Iyama T; Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Nishi-cho 36-1, Yonago, Tottori, 683-8504, Japan.
Kanda T; Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Nishi-cho 36-1, Yonago, Tottori, 683-8504, Japan.
Isomoto H; Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Nishi-cho 36-1, Yonago, Tottori, 683-8504, Japan.; Pokaż więcej
Źródło:: Clinical and experimental nephrology [Clin Exp Nephrol] 2024 Aug; Vol. 28 (8), pp. 728-739. Date of Electronic Publication: 2024 Apr 06.
Typ publikacji:: Journal Article
MeSH Terms:: Zinc*/deficiency
Zinc*/metabolism
Hypertension*/etiology
Hypertension*/physiopathology
Hypertension*/metabolism
Sodium Chloride, Dietary*/adverse effects
Sodium-Hydrogen Exchanger 3*/metabolism
Blood Pressure*
Animals ; Male ; Mice ; Mice, Inbred C57BL ; Solute Carrier Family 12, Member 3/metabolism ; Solute Carrier Family 12, Member 3/genetics ; Sodium/urine ; Sodium/metabolism ; Natriuresis

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Skocz do pozycji: 8.

Tytuł:: Biophysical Analysis of a Minimalistic Kidney Model Expressing SGLT1 Reveals Crosstalk between Luminal and Lateral Membranes and a Plausible Mechanism of Isosmotic Transport.
Autorzy:: Larsen EH; Department of Biology, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Sørensen JN; Department of Wind Energy, Technical University of Denmark, DK-2800 Lyngby, Denmark.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2024 Jul 23; Vol. 14 (8). Date of Electronic Publication: 2024 Jul 23.
Typ publikacji:: Journal Article
MeSH Terms:: Sodium-Glucose Transporter 1*/metabolism
Sodium-Glucose Transporter 1*/genetics
Sodium/metabolism ; Humans ; Biological Transport ; Models, Biological ; Water/metabolism ; Kidney/metabolism ; Tight Junctions/metabolism ; Cell Membrane/metabolism ; Animals ; Sodium-Potassium-Exchanging ATPase/metabolism ; Glucose/metabolism ; Potassium/metabolism

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Skocz do pozycji: 9.

Tytuł:: Moderating effect of a sodium-rich diet on the association between long-term exposure to fine particulate matter and blood lipids in children and adolescents.
Autorzy:: Cao Y; Department of Maternal and Child Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Liu Y; Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Ma M; Sichuan Center for Disease Control and Prevention, Nutrition and Food Hygiene Institute, Chengdu, 610041, Sichuan, China.
Cai J; School of Public Health, Faculty of Medicine, Imperial College London, SW7 2BX, London, United Kingdom.
Liu M; Sichuan Center for Disease Control and Prevention, Nutrition and Food Hygiene Institute, Chengdu, 610041, Sichuan, China.
Zhang R; Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Jiang Y; Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Yan L; Sichuan Center for Disease Control and Prevention, Nutrition and Food Hygiene Institute, Chengdu, 610041, Sichuan, China.
Cao Y; Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Liu Z; Department of Maternal and Child Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. .
Liao J; Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. .; Pokaż więcej
Źródło:: BMC pediatrics [BMC Pediatr] 2024 Jul 20; Vol. 24 (1), pp. 466. Date of Electronic Publication: 2024 Jul 20.
Typ publikacji:: Journal Article
MeSH Terms:: Particulate Matter*/adverse effects
Particulate Matter*/analysis
Sodium, Dietary*
Environmental Exposure*/adverse effects
Environmental Exposure*/analysis
Lipids*/blood
Humans ; Adolescent ; Child ; Male ; Female ; Cross-Sectional Studies ; China ; Sodium/blood ; Sodium/urine ; Diet

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Skocz do pozycji: 10.

Tytuł:: Efficacy of oral sodium chloride in reducing the incidence of hyponatremia in children with epilepsy receiving oxcarbazepine monotherapy: A randomized controlled trial (SCHO Trial).
Autorzy:: Neha KC; Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand 249203, India.
Panda PK; Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand 249203, India.
Mirza AA; Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand 249203, India.
Dhamija P; Department of Pharmacology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand 249203, India.
Sharawat IK; Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand 249203, India. Electronic address: .; Pokaż więcej
Źródło:: Epilepsy & behavior : E&B [Epilepsy Behav] 2024 Sep; Vol. 158, pp. 109939. Date of Electronic Publication: 2024 Jul 12.
Typ publikacji:: Journal Article; Randomized Controlled Trial
MeSH Terms:: Hyponatremia*/prevention & control
Hyponatremia*/chemically induced
Hyponatremia*/epidemiology
Anticonvulsants*/therapeutic use
Anticonvulsants*/adverse effects
Oxcarbazepine*/therapeutic use
Oxcarbazepine*/adverse effects
Epilepsy*/drug therapy
Sodium Chloride*/therapeutic use
Sodium Chloride*/administration & dosage
Sodium Chloride*/adverse effects
Humans ; Female ; Male ; Child ; Child, Preschool ; Infant ; Adolescent ; Administration, Oral ; Incidence ; Treatment Outcome ; Sodium/blood ; Sodium/urine

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Skocz do pozycji: 11.

Tytuł:: ST-2560, a selective inhibitor of the Na V 1.7 sodium channel, affects nocifensive and cardiovascular reflexes in non-human primates.
Autorzy:: Mulcahy JV; SiteOne Therapeutics, Inc., South San Francisco, California, USA.
Beckley JT; SiteOne Therapeutics, Inc., South San Francisco, California, USA.
Klas SD; SiteOne Therapeutics, Inc., South San Francisco, California, USA.
Odink DA; SiteOne Therapeutics, Inc., South San Francisco, California, USA.
Delwig A; SiteOne Therapeutics, Inc., South San Francisco, California, USA.
Pajouhesh H; SiteOne Therapeutics, Inc., South San Francisco, California, USA.
Monteleone D; SiteOne Therapeutics, Inc., South San Francisco, California, USA.
Zhou X; SiteOne Therapeutics, Inc., South San Francisco, California, USA.
Du Bois J; Department of Chemistry, Stanford University, Stanford, California, USA.
Yeomans DC; Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA.
Luu G; SiteOne Therapeutics, Inc., South San Francisco, California, USA.
Hunter JC; SiteOne Therapeutics, Inc., South San Francisco, California, USA.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2024 Sep; Vol. 181 (17), pp. 3160-3171. Date of Electronic Publication: 2024 May 07.
Typ publikacji:: Journal Article
MeSH Terms:: NAV1.7 Voltage-Gated Sodium Channel*/metabolism
Animals ; Male ; Humans ; Female ; Reflex/drug effects ; Sodium Channel Blockers/pharmacology ; Voltage-Gated Sodium Channel Blockers/pharmacology ; Dose-Response Relationship, Drug

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Skocz do pozycji: 12.

Tytuł:: Targeted Approaches: Choosing Sodium Reduction Methods Based on Salt Usage Habits.
Autorzy:: Hu N; Department of Preventive & Social Medicine, University of Otago, P.O. Box 56, Dunedin 9016, New Zealand.
McLean R; Department of Preventive & Social Medicine, University of Otago, P.O. Box 56, Dunedin 9016, New Zealand.; Pokaż więcej
Źródło:: Nutrients [Nutrients] 2024 Aug 23; Vol. 16 (17). Date of Electronic Publication: 2024 Aug 23.
Typ publikacji:: Editorial
MeSH Terms:: Sodium Chloride, Dietary*
Diet, Sodium-Restricted*/methods
Humans ; Sodium, Dietary/administration & dosage ; Feeding Behavior ; Hypertension/prevention & control

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Tytuł:: Development of a selective novel fluorescent substrate for sodium-dependent transporters.
Autorzy:: Agnes RS; Department of Radiology, University Hospitals of Cleveland and Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA. Electronic address: .
Traughber BJ; Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: .
Muzic RF Jr; Department of Radiology, University Hospitals of Cleveland and Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA. Electronic address: .; Pokaż więcej
Źródło:: Life sciences [Life Sci] 2024 Aug 15; Vol. 351, pp. 122847. Date of Electronic Publication: 2024 Jun 14.
Typ publikacji:: Journal Article
MeSH Terms:: Fluorescent Dyes*/metabolism
Sodium-Glucose Transporter 1*/metabolism
Humans ; HEK293 Cells ; Animals ; Swine ; Sodium-Glucose Transporter 2/metabolism ; Glucose/metabolism ; LLC-PK1 Cells ; Biological Transport ; Sodium/metabolism ; Carbocyanines/chemistry ; Carbocyanines/metabolism

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Tytuł:: Enhanced Late I Na Induces Intracellular Ion Disturbances and Automatic Activity in the Guinea Pig Pulmonary Vein Cardiomyocytes.
Autorzy:: Saito T; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama Funabashi, Chiba 274-8510, Japan.
Suzuki M; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama Funabashi, Chiba 274-8510, Japan.
Ohba A; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama Funabashi, Chiba 274-8510, Japan.
Hamaguchi S; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama Funabashi, Chiba 274-8510, Japan.
Namekata I; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama Funabashi, Chiba 274-8510, Japan.
Tanaka H; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama Funabashi, Chiba 274-8510, Japan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 09; Vol. 25 (16). Date of Electronic Publication: 2024 Aug 09.
Typ publikacji:: Journal Article
MeSH Terms:: Pulmonary Veins*/metabolism
Pulmonary Veins*/cytology
Pulmonary Veins*/drug effects
Myocytes, Cardiac*/metabolism
Myocytes, Cardiac*/drug effects
Calcium*/metabolism
Cnidarian Venoms*/pharmacology
Sodium-Calcium Exchanger*/metabolism
Animals ; Guinea Pigs ; Sodium/metabolism ; Male ; Action Potentials/drug effects ; Sodium Channels/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Aniline Compounds/pharmacology ; Sulfonamides/pharmacology ; Calcium Signaling/drug effects ; Isoquinolines ; Phenyl Ethers

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Skocz do pozycji: 15.

Tytuł:: Effect of dapagliflozin on readmission and loop diuretics use in patients with acute heart failure: a retrospective propensity score-matched cohort study.
Autorzy:: Wu D; Department of Pharmacy, Fuyang People's Hospital, Fuyang, Anhui, China.
Ma Z; Department of Cardio Vascular Medicine, Fuyang People's Hospital, Fuyang, Anhui, China.
Wang X; Department of Pharmacy, Fuyang People's Hospital, Fuyang, Anhui, China.
Wang X; Department of Clinical Laboratory, The Second People's Hospital of Fuyang, Fuyang infection Disease Clinical College of Anhui Medical university, Fuyang, Anhui, China. .
Wang X; Department of Pharmacy, Fuyang People's Hospital, Fuyang, Anhui, China. .; Pokaż więcej
Źródło:: BMC cardiovascular disorders [BMC Cardiovasc Disord] 2024 Aug 02; Vol. 24 (1), pp. 402. Date of Electronic Publication: 2024 Aug 02.
Typ publikacji:: Journal Article
MeSH Terms:: Heart Failure*/drug therapy
Heart Failure*/diagnosis
Heart Failure*/physiopathology
Patient Readmission*
Sodium Potassium Chloride Symporter Inhibitors*/therapeutic use
Sodium Potassium Chloride Symporter Inhibitors*/adverse effects
Sodium Potassium Chloride Symporter Inhibitors*/administration & dosage
Glucosides*/adverse effects
Glucosides*/therapeutic use
Glucosides*/administration & dosage
Propensity Score*
Benzhydryl Compounds*/therapeutic use
Benzhydryl Compounds*/adverse effects
Benzhydryl Compounds*/administration & dosage
Humans ; Retrospective Studies ; Male ; Female ; Aged ; Middle Aged ; Treatment Outcome ; Acute Disease ; Time Factors ; Risk Factors ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects ; Drug Therapy, Combination ; China/epidemiology ; Aged, 80 and over ; Risk Assessment

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Tytuł:: The effect of sodium-glucose transporter 2 inhibitors on stroke in patients with type 2 diabetes: A meta-analysis.
Autorzy:: Pasqualotto E; Universidade Federal de Santa Catarina, Brazil. Electronic address: .
Rodrigues FR; Universidade Federal de Viçosa, Brazil. Electronic address: .
E Silva Ribeiro GB; Department of Neurology, Universidade Estadual de Campinas, Brazil. Electronic address: .
de Oliveira Almeida G; Universidade Federal do Triângulo Mineiro, Brazil. Electronic address: .
Kabariti JC; Universidade Federal do Triângulo Mineiro, Brazil. Electronic address: .
Ferreira ROM; Universidade Federal de Santa Catarina, Brazil. Electronic address: .
Chavez MP; Universidade Federal de Santa Catarina, Brazil. Electronic address: .
Clemente MRC; Faculdade de Medicina de Petrópolis, Brazil. Electronic address: .
Sur NB; Department of Neurology, University of Miami Miller School of Medicine, USA. Electronic address: .
Di Luca DG; Department of Neurology, Washington University, USA. Electronic address: .; Pokaż więcej
Źródło:: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2024 Aug; Vol. 33 (8), pp. 107730. Date of Electronic Publication: 2024 Apr 26.
Typ publikacji:: Meta-Analysis; Journal Article; Systematic Review
MeSH Terms:: Diabetes Mellitus, Type 2*/drug therapy
Diabetes Mellitus, Type 2*/complications
Diabetes Mellitus, Type 2*/diagnosis
Sodium-Glucose Transporter 2 Inhibitors*/therapeutic use
Sodium-Glucose Transporter 2 Inhibitors*/adverse effects
Randomized Controlled Trials as Topic*
Stroke*/diagnosis
Stroke*/drug therapy
Humans ; Treatment Outcome ; Risk Factors ; Risk Assessment ; Male ; Female ; Middle Aged ; Aged ; Hemorrhagic Stroke/diagnosis ; Time Factors ; Ischemic Stroke/diagnosis ; Ischemic Stroke/drug therapy ; Sodium-Glucose Transporter 2

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Skocz do pozycji: 17.

Tytuł:: Nanomedicine and voltage-gated sodium channel blockers in pain management: a game changer or a lost cause?
Autorzy:: Le Franc A; Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 91400, Orsay, France.
Da Silva A; Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 91400, Orsay, France.
Lepetre-Mouelhi S; Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 91400, Orsay, France. .; Pokaż więcej
Źródło:: Drug delivery and translational research [Drug Deliv Transl Res] 2024 Aug; Vol. 14 (8), pp. 2112-2145. Date of Electronic Publication: 2024 Jun 11.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Voltage-Gated Sodium Channel Blockers*/administration & dosage
Voltage-Gated Sodium Channel Blockers*/pharmacokinetics
Voltage-Gated Sodium Channel Blockers*/therapeutic use
Pain Management*/methods
Nanomedicine*
Humans ; Animals ; Voltage-Gated Sodium Channels/metabolism ; Anesthetics, Local/administration & dosage ; Anesthetics, Local/therapeutic use ; Anesthetics, Local/pharmacokinetics ; Pain/drug therapy

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Tytuł:: Vitamin D 3 suppresses Npt2c abundance and differentially modulates phosphate and calcium homeostasis in Npt2a knockout mice.
Autorzy:: Thomas L; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.; James A. Haley Veterans' Hospital, Tampa, FL, USA.
Dissanayake LV; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Tahmasbi M; Department of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA.
Staruschenko A; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.; James A. Haley Veterans' Hospital, Tampa, FL, USA.; Hypertension and Kidney Research Center, University of South Florida, Tampa, FL, USA.
Al-Masri S; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Dominguez Rieg JA; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.; James A. Haley Veterans' Hospital, Tampa, FL, USA.; Hypertension and Kidney Research Center, University of South Florida, Tampa, FL, USA.
Rieg T; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. .; James A. Haley Veterans' Hospital, Tampa, FL, USA. .; Hypertension and Kidney Research Center, University of South Florida, Tampa, FL, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Jul 23; Vol. 14 (1), pp. 16997. Date of Electronic Publication: 2024 Jul 23.
Typ publikacji:: Journal Article
MeSH Terms:: Phosphates*/metabolism
Mice, Knockout*
Calcium*/metabolism
Homeostasis*/drug effects
Cholecalciferol*/pharmacology
Cholecalciferol*/metabolism
Sodium-Phosphate Cotransporter Proteins, Type IIa*/metabolism
Sodium-Phosphate Cotransporter Proteins, Type IIa*/genetics
Animals ; Mice ; Kidney/metabolism ; Kidney/drug effects ; Fibroblast Growth Factor-23 ; Parathyroid Hormone/metabolism ; Male ; Hypophosphatemia/metabolism ; Hypophosphatemia/genetics ; Sodium-Phosphate Cotransporter Proteins, Type IIb

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Skocz do pozycji: 19.

Tytuł:: SGLT2 inhibitors attenuate endothelial to mesenchymal transition and cardiac fibroblast activation.
Autorzy:: Schmidt K; Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany.; Fraunhofer Cluster of Excellence Immune-Mediated Diseases (CIMD), Hannover, Germany.
Schmidt A; Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany.; Fraunhofer Cluster of Excellence Immune-Mediated Diseases (CIMD), Hannover, Germany.
Groß S; Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.
Just A; Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.
Pfanne A; Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.
Fuchs M; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany.; Fraunhofer Cluster of Excellence Immune-Mediated Diseases (CIMD), Hannover, Germany.
Jordan M; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany.; Fraunhofer Cluster of Excellence Immune-Mediated Diseases (CIMD), Hannover, Germany.
Mohr E; Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.
Pich A; Institute of Toxicology and Core Unit Proteomics, Hannover Medical School, Hannover, Germany.
Fiedler J; Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany. .; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany. .; Fraunhofer Cluster of Excellence Immune-Mediated Diseases (CIMD), Hannover, Germany. .
Thum T; Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Jul 16; Vol. 14 (1), pp. 16459. Date of Electronic Publication: 2024 Jul 16.
Typ publikacji:: Journal Article
MeSH Terms:: Sodium-Glucose Transporter 2 Inhibitors*/pharmacology
Human Umbilical Vein Endothelial Cells*/drug effects
Human Umbilical Vein Endothelial Cells*/metabolism
Benzhydryl Compounds*/pharmacology
Glucosides*/pharmacology
Fibroblasts*/drug effects
Fibroblasts*/metabolism
Humans ; Epithelial-Mesenchymal Transition/drug effects ; Sodium-Hydrogen Exchanger 1/metabolism ; Sodium-Hydrogen Exchanger 1/antagonists & inhibitors ; Cell Movement/drug effects ; Cell Proliferation/drug effects

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Tytuł:: Inhibiting Nav1.7 channels in pulpitis: An in vivo study on neuronal hyperexcitability.
Autorzy:: Lee KH; Department of Dental Hygiene, Division of Health Science, Dongseo University, Busan, 47011, Republic of Korea.
Kim UJ; Department of Physiology, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Cha M; Department of Physiology, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea. Electronic address: .
Lee BH; Department of Physiology, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea. Electronic address: .; Pokaż więcej
Źródło:: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Jul 12; Vol. 717, pp. 150044. Date of Electronic Publication: 2024 May 03.
Typ publikacji:: Journal Article
MeSH Terms:: NAV1.7 Voltage-Gated Sodium Channel*/metabolism
NAV1.7 Voltage-Gated Sodium Channel*/genetics
Pulpitis*/metabolism
Pulpitis*/pathology
Animals ; Mice ; Male ; Trigeminal Ganglion/metabolism ; Neurons/metabolism ; Nerve Tissue Proteins/metabolism ; Proto-Oncogene Proteins c-fos/metabolism ; Voltage-Gated Sodium Channel Blockers/pharmacology ; Disease Models, Animal ; Intercellular Signaling Peptides and Proteins

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Sodium.