- Tytuł:
- Suppression of MAPK Signaling and Reversal of mTOR-Dependent MDR1-Associated Multidrug Resistance by 21α-Methylmelianodiol in Lung Cancer Cells.
- Autorzy:
- Źródło:
- PloS one [PLoS One] 2015 Jun 22; Vol. 10 (6), pp. e0127841. Date of Electronic Publication: 2015 Jun 22 (Print Publication: 2015).
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Antineoplastic Agents /*pharmacology
Carcinoma, Non-Small-Cell Lung/*drug therapy
Drug Resistance, Neoplasm/*drug effects
Lung Neoplasms/*drug therapy
Triterpenes/*pharmacology
AMP-Activated Protein Kinases/metabolism ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Drug Combinations ; Drug Resistance, Multiple/drug effects ; G1 Phase Cell Cycle Checkpoints/drug effects ; Humans ; MAP Kinase Signaling System/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Neoplasm Invasiveness/pathology ; Paclitaxel/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; RNA Interference ; RNA, Small Interfering ; Reactive Oxygen Species/metabolism ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe