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Wyszukujesz frazę ""Song, Weihong"" wg kryterium: Autor


Tytuł:
The moderated-mediation role of risk perception and intolerance of uncertainty in the association between residual symptoms and psychological distress: a cross-sectional study after COVID-19 policy lifted in China.
Autorzy:
Sun Z; Department of Psychiatry, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China.; Zhejiang Provincial Clinical Research Center for Mental Disorders, Wenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, School of Mental Health and The Affiliated Wenzhou Kangning Hospital, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China.
Jin Z; Zhejiang Provincial Clinical Research Center for Mental Disorders, Wenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, School of Mental Health and The Affiliated Wenzhou Kangning Hospital, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China.
Zhao K; Zhejiang Provincial Clinical Research Center for Mental Disorders, Wenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, School of Mental Health and The Affiliated Wenzhou Kangning Hospital, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China.
Wen X; Zhejiang Provincial Clinical Research Center for Mental Disorders, Wenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, School of Mental Health and The Affiliated Wenzhou Kangning Hospital, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China.
Lu H; Zhejiang Provincial Clinical Research Center for Mental Disorders, Wenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, School of Mental Health and The Affiliated Wenzhou Kangning Hospital, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China.
Hu N; Zhejiang Provincial Clinical Research Center for Mental Disorders, Wenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, School of Mental Health and The Affiliated Wenzhou Kangning Hospital, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China.
Zhu Q; Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Zhejiang Provincial Clinical Research Center for Mental Disorders, Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China.
Zhang Y; Zhejiang Provincial Clinical Research Center for Mental Disorders, Wenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, School of Mental Health and The Affiliated Wenzhou Kangning Hospital, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China.
Ye M; Zhejiang Provincial Clinical Research Center for Mental Disorders, Wenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, School of Mental Health and The Affiliated Wenzhou Kangning Hospital, Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China.
Huang Y; Lyons Insights Consulting, 69534, Lyons, IL, USA.
Song W; Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Zhejiang Provincial Clinical Research Center for Mental Disorders, Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China. weihong@wmu.edu.cn.
Wang DB; Zhejiang Provincial Clinical Research Center for Mental Disorders, Wenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, School of Mental Health and The Affiliated Wenzhou Kangning Hospital, Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China. .
Wu Y; Zhejiang Provincial Clinical Research Center for Mental Disorders, Wenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, School of Mental Health and The Affiliated Wenzhou Kangning Hospital, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China. .
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Źródło:
BMC psychiatry [BMC Psychiatry] 2024 Feb 16; Vol. 24 (1), pp. 136. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19*
Psychological Distress*
Humans ; Cross-Sectional Studies ; Uncertainty ; Depression/psychology ; Anxiety/psychology ; Perception
Czasopismo naukowe
Tytuł:
Fotagliptin monotherapy with alogliptin as an active comparator in patients with uncontrolled type 2 diabetes mellitus: a randomized, multicenter, double-blind, placebo-controlled, phase 3 trial.
Autorzy:
Xu M; Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Sun K; Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Xu W; Shenzhen Salubris Pharmaceuticals Co., Ltd, Shenzhen, China.
Wang C; Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Yan D; Shenzhen Second People's Hospital, Shenzhen, China.
Li S; Huizhou Municipal Central Hospital, Huizhou, China.
Cong L; The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China.
Pi Y; The First Hospital of Changsha, Changsha, China.
Song W; Chenzhou First People's Hospital, Chenzhou, China.
Sun Q; Yueyang Central Hospital, Yueyang, China.
Xiao R; The First Peole's Hospital of Xiangtan City, Xiangtan, China.
Peng W; Yiyang Central Hospital, Yiyang, China.
Wang J; The Second Affiliated Hospital of the University of South China, Hengyang, China.
Peng H; Yichun People's Hospital, The Affiliated Hospital of Yichun University, Yichun, China.
Zhang Y; Pingxiang People's Hospital, Pingxiang, China.
Duan P; The People's Hospital of Nanchang, The Third Hospital of Nanchang, Nanchang, China.
Zhang M; The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Liu J; The First Affiliated Hospital of Nanchang University, Nanchang, China.
Huang Q; Xinyu People's Hospital, Xinyu, China.
Li X; Taihe Hospital, Affilited Hospital of Hubei University of Medicine, Shiyan, China.
Bao Y; Renmin Hospital of Wuhan University, Wuhan, China.
Zeng T; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wang K; Nanjing Jiangning Hospital, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.
Qin L; Chongming Branch, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Wu C; The 2nd School of Medicine, WMU, The 2nd Affiliated Hospital and Yuying Children's Hospital of WMU, Wenzhou, China.
Deng C; Zigong Fourth People's Hospital, Zigong, China.
Huang C; Bishan Hospital of Chongqing, Bishan Hospital of Chongqing Medical University, Chongqing, China.
Yan S; Fourth affiliated hospital of Harbin Medical University, Harbin, China.
Zhang W; The First Hospital of Qiqihar, Qiqihar, China.
Li M; The Affiliated Hospital of Yanbian University, Yanbian, China.
Sun L; Siping Central People's Hospital, Siping, China.
Wang Y; The Second Norman Bethune Hospital of Jilin University, Jilin, China.
Li H; Emergency General Hospital, Beijing, China.
Wang G; Beijing Chao-Yang Hospital, Capital Medicine University, Beijing, China.
Pang S; Jinan Central Hospital, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.
Zheng X; Handan Central Hospital, Handan, China.
Wang H; Handan First Hospital, Handan, China.
Wang F; The Fourth Hospital of He Bei Medical University, Shijiazhuang, China.
Su X; Cangzhou Hospital of Integrated TCM-WM Heibei, Cangzhou, China.
Ma Y; The First Affiliated Hospital and College of Clinical Medicine, Henan University of Science and Technology, Luoyang, China.
Zhang W; Puyang Oilfield General Hospital, Puyang, China.
Li Z; Inner Mongolia Baogang Hospita, Baotou, China.
Xie Z; Zhongda Hospital Southeast University, Nanjing, China.
Xu N; The First People's Hospital of Lianyungang, Lianyungang, China.
Ni L; The First People's Hospital of Huzhou, The First Affiliated Hospital of Huzhou Teacher College, Huzhou, China.
Zhang L; Hainan Third People's Hospital, Sanya, China.
Deng X; Wuhan Third Hospital, Wuhan, China.
Pan T; The Second Hospital of Anhui Medical University, Hefei, China.
Dong Q; People's Hospital of Zhengzhou, People's Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Wu X; Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.
Shen X; Zhongshan Hospital Xiamen University, Xiamen, China.
Zhang X; Genertec Liaoyou Gem Flowe Hospital, Panjin, China.
Zou Q; The Central Hospital of Yougzhou, Yongzhou, China.
Jiang C; The First People's Hospital of Zunyi, Zunyi, China.
Xi J; The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Ma J; Nanjing First Hospital, Nanjing, China.
Sun J; Shenzhen Salubris Pharmaceuticals Co., Ltd, Shenzhen, China.
Yan L; Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. .
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Źródło:
BMC medicine [BMC Med] 2023 Oct 09; Vol. 21 (1), pp. 388. Date of Electronic Publication: 2023 Oct 09.
Typ publikacji:
Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Type 2*/drug therapy
Dipeptidyl-Peptidase IV Inhibitors*/adverse effects
Humans ; Glycated Hemoglobin ; Blood Glucose ; Hypoglycemic Agents/adverse effects ; Double-Blind Method ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Upregulation of carbonic anhydrase 1 beneficial for depressive disorder.
Autorzy:
Cheng K; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.; Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
Wang Y; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.; Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
He Y; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Tian Y; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Li J; Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing, 400014, China.; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Chen C; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Xu X; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Wu Z; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Yu H; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Chen X; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Wu Y; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Institute of Aging, Zhejiang Provincial Clinical Research Center for Mental Disorders, Key Laboratory of Alzheimer's Disease of Zhejiang Province, School of Mental Health and Kangning Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Song W; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Institute of Aging, Zhejiang Provincial Clinical Research Center for Mental Disorders, Key Laboratory of Alzheimer's Disease of Zhejiang Province, School of Mental Health and Kangning Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. weihong@mail.ubc.ca.
Dong Z; Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing, 400014, China. .; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China. .
Xu H; Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China. .; Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai, 201210, China. .
Xie P; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. .; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Apr 03; Vol. 11 (1), pp. 59. Date of Electronic Publication: 2023 Apr 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Depressive Disorder, Major*/genetics
Carbonic Anhydrases*/genetics
Carbonic Anhydrases*/metabolism
Mice ; Animals ; Up-Regulation ; Mice, Knockout ; Transcriptional Activation
Czasopismo naukowe
Tytuł:
COVID-19 vaccine uptake and vaccine hesitancy in rural-to-urban migrant workers at the first round of COVID-19 vaccination in China.
Autorzy:
Hong L; School of Mental Health, Wenzhou Medical University, Wenzhou, China.
Jin Z; School of Mental Health, Wenzhou Medical University, Wenzhou, China.; Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Zhejiang Provincial Clinical Research Center for Mental Disorders, School of Mental Health and The Affiliated Kangning Hospital, Wenzhou Medical University, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, 325000, Zhejiang, China.
Xu K; School of Mental Health, Wenzhou Medical University, Wenzhou, China.
Shen G; School of Mental Health, Wenzhou Medical University, Wenzhou, China.
Zou Y; School of Mental Health, Wenzhou Medical University, Wenzhou, China.
Li R; Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Zhejiang Provincial Clinical Research Center for Mental Disorders, School of Mental Health and The Affiliated Kangning Hospital, Wenzhou Medical University, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, 325000, Zhejiang, China.; The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China.
Xu L; School of Mental Health, Wenzhou Medical University, Wenzhou, China.; Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Zhejiang Provincial Clinical Research Center for Mental Disorders, School of Mental Health and The Affiliated Kangning Hospital, Wenzhou Medical University, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, 325000, Zhejiang, China.
Wang D; The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China.
Chen L; School of Mental Health, Wenzhou Medical University, Wenzhou, China. .; Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Zhejiang Provincial Clinical Research Center for Mental Disorders, School of Mental Health and The Affiliated Kangning Hospital, Wenzhou Medical University, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, 325000, Zhejiang, China. .
Wu Y; School of Mental Health, Wenzhou Medical University, Wenzhou, China. .; Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Zhejiang Provincial Clinical Research Center for Mental Disorders, School of Mental Health and The Affiliated Kangning Hospital, Wenzhou Medical University, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, 325000, Zhejiang, China. .
Song W; School of Mental Health, Wenzhou Medical University, Wenzhou, China. weihong@wmu.edu.cn.; Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Zhejiang Provincial Clinical Research Center for Mental Disorders, School of Mental Health and The Affiliated Kangning Hospital, Wenzhou Medical University, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, 325000, Zhejiang, China. weihong@wmu.edu.cn.; The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China. weihong@wmu.edu.cn.
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Źródło:
BMC public health [BMC Public Health] 2023 Jan 20; Vol. 23 (1), pp. 139. Date of Electronic Publication: 2023 Jan 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19*/epidemiology
COVID-19*/prevention & control
Transients and Migrants*
Female ; Humans ; COVID-19 Vaccines ; Cross-Sectional Studies ; Reproducibility of Results ; Vaccination Hesitancy ; Vaccination ; China/epidemiology
Czasopismo naukowe
Tytuł:
Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential.
Autorzy:
Gao L; Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, College of Pharmacy, Jining Medical University, Jining, 272067, Shandong, China.; Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
Zhang Y; National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Sterling K; Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
Song W; Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, College of Pharmacy, Jining Medical University, Jining, 272067, Shandong, China. weihong@wmu.edu.cn.; Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada. weihong@wmu.edu.cn.; National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. weihong@wmu.edu.cn.; Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, School of Mental Health and The Affiliated Kangning Hospital, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. weihong@wmu.edu.cn.; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, 325001, Zhejiang, China. weihong@wmu.edu.cn.
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Źródło:
Translational neurodegeneration [Transl Neurodegener] 2022 Jan 28; Vol. 11 (1), pp. 4. Date of Electronic Publication: 2022 Jan 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/genetics
Alzheimer Disease*/pathology
Amyloid beta-Peptides ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/pharmacology ; Humans ; Neurons/pathology ; Pharmaceutical Preparations
Czasopismo naukowe
Tytuł:
TRPV1 activation alleviates cognitive and synaptic plasticity impairments through inhibiting AMPAR endocytosis in APP23/PS45 mouse model of Alzheimer's disease.
Autorzy:
Du Y; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Fu M; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Huang Z; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Tian X; Department of Neurology, Chongqing Key Laboratory of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Li J; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Pang Y; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Song W; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; Department of Psychiatry, Townsend Family Laboratories, University of British Columbia, Vancouver, BC, Canada.
Tian Wang Y; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; Brain Research Centre, University of British Columbia, Vancouver, BC, Canada.
Dong Z; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
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Źródło:
Aging cell [Aging Cell] 2020 Mar; Vol. 19 (3), pp. e13113. Date of Electronic Publication: 2020 Feb 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease/*metabolism
Cognitive Dysfunction/*metabolism
Endocytosis/*genetics
Long-Term Potentiation/*genetics
Receptors, AMPA/*metabolism
TRPV Cation Channels/*metabolism
Alzheimer Disease/genetics ; Amyloid beta-Peptides/metabolism ; Animals ; CA1 Region, Hippocampal/metabolism ; Cognitive Dysfunction/genetics ; Disease Models, Animal ; Maze Learning ; Memory ; Mice ; Mice, Transgenic ; Signal Transduction/drug effects ; Spatial Learning ; Synapses/metabolism ; TRPV Cation Channels/genetics
Czasopismo naukowe
Tytuł:
A novel de novo nonsense mutation in ZC4H2 causes Wieacker-Wolff Syndrome.
Autorzy:
Wang D; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Hu D; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Guo Z; Department of Internal Neurology, Children's Hospital of Chongqing Medical University, Chongqing, China.
Hu R; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Wang Q; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Liu Y; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Liu M; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Meng Z; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Yang H; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Zhang Y; Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, Vancouver, BC, Canada.
Cai F; Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, Vancouver, BC, Canada.
Zhou W; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Song W; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, Vancouver, BC, Canada.
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Źródło:
Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2020 Feb; Vol. 8 (2), pp. e1100. Date of Electronic Publication: 2019 Dec 30.
Typ publikacji:
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Codon, Nonsense*
Apraxias/*genetics
Contracture/*genetics
Genetic Diseases, X-Linked/*genetics
Intracellular Signaling Peptides and Proteins/*genetics
Muscular Atrophy/*genetics
Nuclear Proteins/*genetics
Ophthalmoplegia/*genetics
Apraxias/pathology ; Contracture/pathology ; Female ; Genetic Diseases, X-Linked/pathology ; HEK293 Cells ; Humans ; Infant ; Intracellular Signaling Peptides and Proteins/chemistry ; Intracellular Signaling Peptides and Proteins/metabolism ; Muscular Atrophy/pathology ; Nuclear Proteins/chemistry ; Nuclear Proteins/metabolism ; Ophthalmoplegia/pathology ; Protein Domains ; X Chromosome Inactivation
SCR Disease Name:
Wieacker syndrome
Czasopismo naukowe
Tytuł:
Transcriptional activation of USP16 gene expression by NFκB signaling.
Autorzy:
Yang S; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Wang J; Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
Guo S; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Huang D; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Lorigados IB; Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
Nie X; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Lou D; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Li Y; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Liu M; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Kang Y; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Zhou W; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China. .
Song W; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China. weihong@mail.ubc.ca.; Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada. weihong@mail.ubc.ca.
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Źródło:
Molecular brain [Mol Brain] 2019 Dec 30; Vol. 12 (1), pp. 120. Date of Electronic Publication: 2019 Dec 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Signal Transduction*
NF-kappa B/*metabolism
Transcriptional Activation/*genetics
Ubiquitin Thiolesterase/*genetics
Animals ; Base Sequence ; Binding Sites/genetics ; Cell Line ; Humans ; Mice ; Promoter Regions, Genetic ; Sequence Deletion ; Transcription, Genetic ; Ubiquitin Thiolesterase/metabolism ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł:
Upregulation of MIF as a defense mechanism and a biomarker of Alzheimer's disease.
Autorzy:
Zhang S; Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
Zhao J; Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
Zhang Y; Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
Zhang Y; Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
Cai F; Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
Wang L; Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China. .
Song W; Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada. weihong@mail.ubc.ca.
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2019 Jun 07; Vol. 11 (1), pp. 54. Date of Electronic Publication: 2019 Jun 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease/*metabolism
Brain/*metabolism
Intramolecular Oxidoreductases/*biosynthesis
Macrophage Migration-Inhibitory Factors/*biosynthesis
Up-Regulation/*physiology
Adult ; Aged ; Alzheimer Disease/cerebrospinal fluid ; Alzheimer Disease/diagnostic imaging ; Animals ; Biomarkers/cerebrospinal fluid ; Biomarkers/metabolism ; Female ; Humans ; Intramolecular Oxidoreductases/cerebrospinal fluid ; Macrophage Migration-Inhibitory Factors/cerebrospinal fluid ; Male ; Maze Learning/physiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Transgenic ; Middle Aged
Czasopismo naukowe
Tytuł:
Exome sequencing in multiple sclerosis families identifies 12 candidate genes and nominates biological pathways for the genesis of disease.
Autorzy:
Vilariño-Güell C; Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Zimprich A; Department of Neurology, Medical University of Vienna, Vienna, Austria.
Martinelli-Boneschi F; Laboratory of Human Genetics of Neurological Disorders, CNS Inflammatory Unit, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy.; MS Unit and Department of Neurology, IRCCS Policlinico San Donato, Milan, Italy.; Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Herculano B; Townsend Family Laboratories, Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Wang Z; Townsend Family Laboratories, Department of Psychiatry, University of British Columbia, Vancouver, Canada.; National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of the Capital Medical University, Beijing, China.
Matesanz F; Department of Cell Biology and Immunology, Instituto de Parasitología y Biomedicina López Neyra (IPBLN), CSIC, Granada, Spain.
Urcelay E; Immunology Dept, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.; Red Española de Esclerosis Múltiple REEM, Madrid, Spain.
Vandenbroeck K; Achucarro Basque Center for Neuroscience, Universidad del País Vasco (UPV/EHU), Leioa, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.
Leyva L; Red Española de Esclerosis Múltiple REEM, Madrid, Spain.; Instituto de Investigación Biomédica de Málaga-IBIMA, Unidad de Gestion Clínica de Neurociencias, Hospital Regional Universitario de Málaga, Málaga, Spain.
Gris D; Division of Immunology, Department of Pediatrics, CR-CHUS, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Canada.
Massaad C; Toxicology, Pharmacology and Cell Signalisation-UMR-S 1124 Université Paris Descartes, Paris, France.
Quandt JA; Department of Pathology, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Traboulsee AL; Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Encarnacion M; Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Bernales CQ; Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Follett J; Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Yee IM; Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Criscuoli MG; Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Deutschländer A; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, United States of America.; Department of Clinical Genomics, Mayo Clinic Florida, Jacksonville, FL, United States of America.; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, United States of America.
Reinthaler EM; Department of Neurology, Medical University of Vienna, Vienna, Austria.
Zrzavy T; Department of Neurology, Medical University of Vienna, Vienna, Austria.
Mascia E; Laboratory of Human Genetics of Neurological Disorders, CNS Inflammatory Unit, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Zauli A; Laboratory of Human Genetics of Neurological Disorders, CNS Inflammatory Unit, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Esposito F; Laboratory of Human Genetics of Neurological Disorders, CNS Inflammatory Unit, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Alcina A; Department of Cell Biology and Immunology, Instituto de Parasitología y Biomedicina López Neyra (IPBLN), CSIC, Granada, Spain.
Izquierdo G; Unidad de Esclerosis Múltiple, Hospital Virgen Macarena, Sevilla, Spain.
Espino-Paisán L; Immunology Dept, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.; Red Española de Esclerosis Múltiple REEM, Madrid, Spain.
Mena J; Achucarro Basque Center for Neuroscience, Universidad del País Vasco (UPV/EHU), Leioa, Spain.
Antigüedad A; Neurology Department, Hospital Universitario de Cruces, S/N, Baracaldo, Spain.
Urbaneja-Romero P; Red Española de Esclerosis Múltiple REEM, Madrid, Spain.; Instituto de Investigación Biomédica de Málaga-IBIMA, Unidad de Gestion Clínica de Neurociencias, Hospital Regional Universitario de Málaga, Málaga, Spain.
Ortega-Pinazo J; Instituto de Investigación Biomédica de Málaga-IBIMA, Unidad de Gestion Clínica de Neurociencias, Hospital Regional Universitario de Málaga, Málaga, Spain.
Song W; Townsend Family Laboratories, Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Sadovnick AD; Department of Medical Genetics, University of British Columbia, Vancouver, Canada.; Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
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Źródło:
PLoS genetics [PLoS Genet] 2019 Jun 06; Vol. 15 (6), pp. e1008180. Date of Electronic Publication: 2019 Jun 06 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Predisposition to Disease*
Inflammation/*genetics
Multiple Sclerosis/*genetics
Transcriptome/*genetics
Adult ; Codon, Nonsense ; Demyelinating Diseases/genetics ; Demyelinating Diseases/pathology ; Exome/genetics ; Female ; Humans ; Inflammation/metabolism ; Inflammation/pathology ; Male ; Middle Aged ; Multiple Sclerosis/metabolism ; Multiple Sclerosis/pathology ; Myelin Sheath/genetics ; Myelin Sheath/pathology ; Nerve Degeneration/genetics ; Nerve Degeneration/pathology ; Neurons/metabolism ; Neurons/pathology ; Pedigree ; Exome Sequencing ; Young Adult
Czasopismo naukowe
Tytuł:
Regulation of global gene expression in brain by TMP21.
Autorzy:
Zhang X; Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.; National Clinical Research Center for Mental Disorders, Changsha, Hunan, China.; Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
Wu Y; Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jining, Shandong, China.
Cai F; Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
Song W; Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada. weihong@mail.ubc.ca.
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Źródło:
Molecular brain [Mol Brain] 2019 Apr 29; Vol. 12 (1), pp. 39. Date of Electronic Publication: 2019 Apr 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation*
Brain/*metabolism
Membrane Proteins/*metabolism
Animals ; Epistasis, Genetic ; Gene Expression Profiling ; Gene Ontology ; Gene Regulatory Networks ; Hippocampus/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Transcription, Genetic
Czasopismo naukowe
Tytuł:
Regulation of LRRK2 promoter activity and gene expression by Sp1.
Autorzy:
Wang J; Department of Psychiatry, Townsend Family Laboratories, Graduate Program in Neuroscience, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
Song W; Department of Psychiatry, Townsend Family Laboratories, Graduate Program in Neuroscience, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada. weihong@mail.ubc.ca.
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Źródło:
Molecular brain [Mol Brain] 2016 Mar 22; Vol. 9, pp. 33. Date of Electronic Publication: 2016 Mar 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation*
Promoter Regions, Genetic*
Protein Serine-Threonine Kinases/*genetics
Sp1 Transcription Factor/*metabolism
Base Sequence ; Binding Sites ; Cloning, Molecular ; HEK293 Cells ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 ; Molecular Sequence Data ; Plicamycin/analogs & derivatives ; Plicamycin/pharmacology ; Protein Serine-Threonine Kinases/metabolism ; Sequence Deletion ; Transcription Initiation Site ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł:
Regulation of global gene expression and cell proliferation by APP.
Autorzy:
Wu Y; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.; Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.; Department of Psychiatry, Jining Medical University, Jining, Shandong, 272067, China.
Zhang S; Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Xu Q; Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.
Zou H; Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.
Zhou W; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.; Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Cai F; Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.
Li T; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.; Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Song W; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.; Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.; Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.
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Źródło:
Scientific reports [Sci Rep] 2016 Mar 03; Vol. 6, pp. 22460. Date of Electronic Publication: 2016 Mar 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Proliferation*
Gene Expression Regulation*
Amyloid beta-Protein Precursor/*metabolism
Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Amyloid beta-Protein Precursor/genetics ; Down Syndrome/genetics ; Down Syndrome/metabolism ; HEK293 Cells ; Humans ; Proteasome Endopeptidase Complex/biosynthesis ; Proteasome Endopeptidase Complex/genetics ; Tumor Suppressor Protein p53/biosynthesis ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł:
Melatonin regulates the transcription of βAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells.
Autorzy:
Panmanee J; Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakhonpathom, Thailand.
Nopparat C; Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakhonpathom, Thailand.
Chavanich N; Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakhonpathom, Thailand.
Shukla M; Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakhonpathom, Thailand.
Mukda S; Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakhonpathom, Thailand.
Song W; Townsend Family Laboratories, Department of Psychiatry, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
Vincent B; Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakhonpathom, Thailand.; Centre National de la Recherche Scientifique, Paris, France.
Govitrapong P; Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakhonpathom, Thailand.; Center for Neuroscience and Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand.
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Źródło:
Journal of pineal research [J Pineal Res] 2015 Oct; Vol. 59 (3), pp. 308-20. Date of Electronic Publication: 2015 Jul 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
ADAM Proteins/*metabolism
Amyloid Precursor Protein Secretases/*metabolism
Amyloid beta-Peptides/*metabolism
Aspartic Acid Endopeptidases/*metabolism
Melatonin/*pharmacology
Membrane Proteins/*metabolism
Neuroblastoma/*metabolism
Receptors, Melatonin/*metabolism
ADAM Proteins/genetics ; ADAM10 Protein ; Amyloid Precursor Protein Secretases/genetics ; Aspartic Acid Endopeptidases/genetics ; Cell Line, Tumor ; Gene Expression/drug effects ; Gene Expression/genetics ; Humans ; Membrane Proteins/genetics ; Neuroblastoma/genetics ; Presenilins/genetics ; Presenilins/metabolism ; Receptors, Melatonin/genetics
Czasopismo naukowe
Tytuł:
Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo.
Autorzy:
Zhang M; Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.
Cai F; Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.
Zhang S; Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.
Zhang S; Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.
Song W; Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.
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Źródło:
Scientific reports [Sci Rep] 2014 Dec 03; Vol. 4, pp. 7298. Date of Electronic Publication: 2014 Dec 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease/*metabolism
Alzheimer Disease/*pathology
Ubiquitin Thiolesterase/*metabolism
Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Animals ; DNA, Complementary/metabolism ; Disease Models, Animal ; Disease Progression ; Humans ; Memory Disorders/metabolism ; Memory Disorders/pathology ; Mice ; Mice, Transgenic/metabolism ; Plaque, Amyloid/metabolism ; Plaque, Amyloid/pathology ; Ubiquitins/metabolism
Czasopismo naukowe
Tytuł:
Two novel DNA motifs are essential for BACE1 gene transcription.
Autorzy:
Xiang Y; Ministry of Education Key Laboratory of Child Development and Disorders; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, 136 ZhongshanEr Lu, Yuzhong District, Chongqing 400014, China.
Meng S; Ministry of Education Key Laboratory of Child Development and Disorders; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, 136 ZhongshanEr Lu, Yuzhong District, Chongqing 400014, China.
Wang J; Ministry of Education Key Laboratory of Child Development and Disorders; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, 136 ZhongshanEr Lu, Yuzhong District, Chongqing 400014, China.
Li S; Ministry of Education Key Laboratory of Child Development and Disorders; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, 136 ZhongshanEr Lu, Yuzhong District, Chongqing 400014, China.
Liu J; Ministry of Education Key Laboratory of Child Development and Disorders; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, 136 ZhongshanEr Lu, Yuzhong District, Chongqing 400014, China.
Li H; Ministry of Education Key Laboratory of Child Development and Disorders; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, 136 ZhongshanEr Lu, Yuzhong District, Chongqing 400014, China.
Li T; Ministry of Education Key Laboratory of Child Development and Disorders; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, 136 ZhongshanEr Lu, Yuzhong District, Chongqing 400014, China.
Song W; 1] Ministry of Education Key Laboratory of Child Development and Disorders; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, 136 ZhongshanEr Lu, Yuzhong District, Chongqing 400014, China [2] Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, University of British Columbia, Vancouver, British Columbia, V6T1Z3, Canada.
Zhou W; Ministry of Education Key Laboratory of Child Development and Disorders; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, 136 ZhongshanEr Lu, Yuzhong District, Chongqing 400014, China.
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Źródło:
Scientific reports [Sci Rep] 2014 Oct 31; Vol. 4, pp. 6864. Date of Electronic Publication: 2014 Oct 31.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation*
Nucleotide Motifs*
Transcription, Genetic*
Amyloid Precursor Protein Secretases/*genetics
Aspartic Acid Endopeptidases/*genetics
Amyloid Precursor Protein Secretases/chemistry ; Aspartic Acid Endopeptidases/chemistry ; Base Sequence ; Cell Line ; Conserved Sequence ; Humans ; Molecular Sequence Data ; Promoter Regions, Genetic ; Response Elements ; Transcriptional Activation
Czasopismo naukowe
Tytuł:
5-Mehtyltetrahydrofolate rescues alcohol-induced neural crest cell migration abnormalities.
Autorzy:
Shi Y
Li J
Chen C
Gong M
Chen Y
Liu Y
Chen J
Li T
Song W
Pokaż więcej
Źródło:
Molecular brain [Mol Brain] 2014 Sep 16; Vol. 7, pp. 67. Date of Electronic Publication: 2014 Sep 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Movement/*drug effects
Ethanol/*toxicity
Neural Crest/*pathology
Tetrahydrofolates/*pharmacology
Animals ; Apoptosis/drug effects ; Cartilage/drug effects ; Cartilage/embryology ; Models, Animal ; Neural Crest/drug effects ; Neural Plate/drug effects ; Neural Plate/pathology ; Pigments, Biological/metabolism ; Xenopus laevis/embryology
Czasopismo naukowe
Tytuł:
Upregulation of human PINK1 gene expression by NFκB signalling.
Autorzy:
Duan X
Tong J
Xu Q
Wu Y
Cai F
Li T
Song W
Pokaż więcej
Źródło:
Molecular brain [Mol Brain] 2014 Aug 11; Vol. 7, pp. 57. Date of Electronic Publication: 2014 Aug 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
NF-kappa B/*metabolism
Protein Kinases/*genetics
Signal Transduction/*genetics
Up-Regulation/*genetics
Animals ; Base Sequence ; Binding Sites/genetics ; HEK293 Cells ; Humans ; Mice ; Molecular Sequence Data ; Promoter Regions, Genetic ; Protein Binding/genetics ; Protein Kinases/metabolism ; Sequence Deletion/genetics ; Transcription Initiation Site
Czasopismo naukowe
Tytuł:
RCAN1 overexpression exacerbates calcium overloading-induced neuronal apoptosis.
Autorzy:
Sun X; Qilu Hospital of Shandong University, Jinan, China; Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, Graduate Program in Neuroscience, The University of British Columbia, Vancouver, Canada.
Wu Y; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China; Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, Graduate Program in Neuroscience, The University of British Columbia, Vancouver, Canada.
Herculano B; Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, Graduate Program in Neuroscience, The University of British Columbia, Vancouver, Canada.
Song W; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China; Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, Graduate Program in Neuroscience, The University of British Columbia, Vancouver, Canada.
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Źródło:
PloS one [PLoS One] 2014 Apr 21; Vol. 9 (4), pp. e95471. Date of Electronic Publication: 2014 Apr 21 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*/genetics
Calcium/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Muscle Proteins/*metabolism
Neurons/*cytology
Neurons/*metabolism
Animals ; Base Sequence ; Caspase 3/metabolism ; Cell Line ; DNA-Binding Proteins ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Molecular Sequence Data ; Muscle Proteins/genetics ; NFATC Transcription Factors/metabolism ; Neurotoxins/toxicity ; Promoter Regions, Genetic/genetics ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Signal Transduction/genetics ; Transcription, Genetic ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł:
High glucose promotes Aβ production by inhibiting APP degradation.
Autorzy:
Yang Y; Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, Graduate Program in Neuroscience, The University of British Columbia, Vancouver, Canada.
Wu Y
Zhang S
Song W
Pokaż więcej
Źródło:
PloS one [PLoS One] 2013 Jul 23; Vol. 8 (7), pp. e69824. Date of Electronic Publication: 2013 Jul 23 (Print Publication: 2013).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyloid beta-Peptides/*biosynthesis
Amyloid beta-Protein Precursor/*metabolism
Glucose/*metabolism
Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Cell Line, Tumor ; Glucose/pharmacology ; Humans ; Peptide Fragments/metabolism ; Transcription, Genetic
Czasopismo naukowe

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