Autor: "Souza BBP" - OpacWWW

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Tytuł:: Structural insights and molecular dynamics into the inhibitory mechanism of a Kunitz-type trypsin inhibitor from Tamarindus indica L.
Autorzy:: de Medeiros AF; Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
de Souza BBP; Postgraduate Biological Molecular, Institute of Biological Sciences, University of Brasília, Brasília, Brazil.; Laboratory of Mass Spectometry-LEM, Embrapa Genetic Resources and Biotechnology, Brasília, Brazil.
Coutinho LP; Chemistry Course, Science Center, Federal University of Ceará, Fortaleza, Brazil.
Murad AM; Laboratory of Mass Spectometry-LEM, Embrapa Genetic Resources and Biotechnology, Brasília, Brazil.
Dos Santos PIM; Federal Institute of Education, Science and Technology of Rio Grande do Norte, Brazil.
Monteiro NKV; Analytical Chemistry and physical Chemistry Department, Science Center, Federal University of Ceará, Fortaleza, Brazil.
Santos EAD; Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.; Department of Biochemistry, Biosciences Center, Federal University of Rio Grande, Natal, Brazil.; Tropical Medicine Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
Maciel BLL; Postgraduate Nutrition Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.; Department of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
de Araújo Morais AH; Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.; Postgraduate Nutrition Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.; Department of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 480-490.
Typ publikacji:: Journal Article
MeSH Terms:: Molecular Dynamics Simulation*
Plant Extracts/*pharmacology
Tamarindus/*chemistry
Trypsin/*metabolism
Trypsin Inhibitors/*pharmacology
Dose-Response Relationship, Drug ; Molecular Structure ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Seeds/chemistry ; Structure-Activity Relationship ; Trypsin Inhibitors/chemistry ; Trypsin Inhibitors/isolation & purification

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Skocz do pozycji: 2.

Tytuł:: Biochemical characterisation of a Kunitz-type inhibitor from Tamarindus indica L. seeds and its efficacy in reducing plasma leptin in an experimental model of obesity.
Autorzy:: Medeiros AF; a Postgraduate Biochemistry Program, Biosciences Center , Federal University of Rio Grande do Norte , Natal , Brazil.
Costa IS; a Postgraduate Biochemistry Program, Biosciences Center , Federal University of Rio Grande do Norte , Natal , Brazil.
Carvalho FMC; a Postgraduate Biochemistry Program, Biosciences Center , Federal University of Rio Grande do Norte , Natal , Brazil.
Kiyota S; b Laboratory of Protein and Peptide Biochemistry , CPDSA, Biological Institute , São Paulo , Brazil.
Souza BBP; c Postgraduate Biological Molecular, Institute of Biological Sciences , University of Brasília , Distrito Federal , Brasília , Brazil.; d Embrapa Genetic Resources and Biotechnology , Embrapa , Distrito Federal , Brasília , Brazil.
Sifuentes DN; d Embrapa Genetic Resources and Biotechnology , Embrapa , Distrito Federal , Brasília , Brazil.
Serquiz RP; a Postgraduate Biochemistry Program, Biosciences Center , Federal University of Rio Grande do Norte , Natal , Brazil.
Maciel BLL; e Postgraduate Nutrition Program, Center for Health Sciences , Federal University of Rio Grande do Norte , Natal , Brazil.; f Department of Nutrition, Center for Health Sciences , Federal University of Rio Grande do Norte , Natal , Brazil.
Uchôa AF; a Postgraduate Biochemistry Program, Biosciences Center , Federal University of Rio Grande do Norte , Natal , Brazil.; g Department of Cell Biology and Genetics, Biosciences Center , Federal University of Rio Grande do Norte , Natal , Brazil.
Santos EAD; a Postgraduate Biochemistry Program, Biosciences Center , Federal University of Rio Grande do Norte , Natal , Brazil.; h Department of Biochemistry, Biosciences Center , Federal University of Rio Grande do Norte , Natal , Brazil.
Morais AHA; a Postgraduate Biochemistry Program, Biosciences Center , Federal University of Rio Grande do Norte , Natal , Brazil.; e Postgraduate Nutrition Program, Center for Health Sciences , Federal University of Rio Grande do Norte , Natal , Brazil.; f Department of Nutrition, Center for Health Sciences , Federal University of Rio Grande do Norte , Natal , Brazil.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2018 Dec; Vol. 33 (1), pp. 334-348.
Typ publikacji:: Journal Article
MeSH Terms:: Disease Models, Animal*
Anti-Obesity Agents/*pharmacology
Leptin/*blood
Obesity/*blood
Obesity/*drug therapy
Peptides/*pharmacology
Plant Proteins/*pharmacology
Tamarindus/*chemistry
Animals ; Anti-Obesity Agents/chemistry ; Anti-Obesity Agents/isolation & purification ; Dose-Response Relationship, Drug ; Male ; Obesity/metabolism ; Peptides/chemistry ; Peptides/isolation & purification ; Plant Proteins/chemistry ; Plant Proteins/isolation & purification ; Rats ; Rats, Wistar ; Seeds/chemistry ; Structure-Activity Relationship ; Trypsin/metabolism

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