Trifloxystrobin blocks the growth of Theileria parasites and is a promising drug to treat Buparvaquone resistance.
Autorzy:
Villares M; Université Paris Cité, Epigenetics and Cell Fate, CNRS, F-75013, Paris, France. Lourenço N; Université Paris Cité, Epigenetics and Cell Fate, CNRS, F-75013, Paris, France. Berthelet J; Université Paris Cité, Epigenetics and Cell Fate, CNRS, F-75013, Paris, France. Lamotte S; Institut Pasteur, Université Paris Cité, INSERM U1201, Molecular Parasitology and Signaling Unit, Paris, France. Regad L; Université Paris Cité, BFA, UMR 8251, CNRS, ERL U1133, Inserm, F-75013, Paris, France. Medjkane S; Université Paris Cité, Epigenetics and Cell Fate, CNRS, F-75013, Paris, France. Prina E; Institut Pasteur, Université Paris Cité, INSERM U1201, Molecular Parasitology and Signaling Unit, Paris, France. Rodrigues-Lima F; Université Paris Cité, BFA, UMR 8251, CNRS, ERL U1133, Inserm, F-75013, Paris, France. SpäthGF; Institut Pasteur, Université Paris Cité, INSERM U1201, Molecular Parasitology and Signaling Unit, Paris, France. Weitzman JB; Université Paris Cité, Epigenetics and Cell Fate, CNRS, F-75013, Paris, France. .
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Communications biology [Commun Biol] 2022 Nov 15; Vol. 5 (1), pp. 1253. Date of Electronic Publication: 2022 Nov 15.
Experimental evolution links post-transcriptional regulation to Leishmania fitness gain.
Autorzy:
Piel L; Institut Pasteur, Université de Paris, INSERM U1201, Unité de Parasitologie moléculaire et Signalisation, Paris, France. Rajan KS; The Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan, Israel. Bussotti G; Institut Pasteur, Université de Paris, INSERM U1201, Unité de Parasitologie moléculaire et Signalisation, Paris, France.; Institut Pasteur, Bioinformatics and Biostatistics Hub, Department of Computational Biology, USR 3756 IP CNRS, Paris, France. Varet H; Institut Pasteur, Bioinformatics and Biostatistics Hub, Department of Computational Biology, USR 3756 IP CNRS, Paris, France.; Institut Pasteur, Biomics, Paris, France; Institut Pasteur, UTechS MSBio, Paris, France. Legendre R; Institut Pasteur, Bioinformatics and Biostatistics Hub, Department of Computational Biology, USR 3756 IP CNRS, Paris, France.; Institut Pasteur, Biomics, Paris, France; Institut Pasteur, UTechS MSBio, Paris, France. Proux C; Institut Pasteur, Biomics, Paris, France; Institut Pasteur, UTechS MSBio, Paris, France. Douché T; Institut Pasteur, Proteomics Platform Mass Spectrometry for Biology UTechS, C2RT, USR2000 CNRS, Paris, France. Giai-Gianetto Q; Institut Pasteur, Bioinformatics and Biostatistics Hub, Department of Computational Biology, USR 3756 IP CNRS, Paris, France.; Institut Pasteur, Proteomics Platform Mass Spectrometry for Biology UTechS, C2RT, USR2000 CNRS, Paris, France. Chaze T; Institut Pasteur, Proteomics Platform Mass Spectrometry for Biology UTechS, C2RT, USR2000 CNRS, Paris, France. Cokelaer T; Institut Pasteur, Bioinformatics and Biostatistics Hub, Department of Computational Biology, USR 3756 IP CNRS, Paris, France.; Institut Pasteur, Biomics, Paris, France; Institut Pasteur, UTechS MSBio, Paris, France. Vojtkova B; Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic. Gordon-Bar N; The Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan, Israel. Doniger T; The Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan, Israel. Cohen-Chalamish S; The Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan, Israel. Rengaraj P; The Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan, Israel. Besse C; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France. Boland A; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France. Sadlova J; Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic. Deleuze JF; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France. Matondo M; Institut Pasteur, Proteomics Platform Mass Spectrometry for Biology UTechS, C2RT, USR2000 CNRS, Paris, France. Unger R; The Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan, Israel. Volf P; Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic. Michaeli S; The Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan, Israel. Pescher P; Institut Pasteur, Université de Paris, INSERM U1201, Unité de Parasitologie moléculaire et Signalisation, Paris, France. SpäthGF; Institut Pasteur, Université de Paris, INSERM U1201, Unité de Parasitologie moléculaire et Signalisation, Paris, France.
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Źródło:
PLoS pathogens [PLoS Pathog] 2022 Mar 16; Vol. 18 (3), pp. e1010375. Date of Electronic Publication: 2022 Mar 16 (Print Publication: 2022).
Colonization and genetic diversification processes of Leishmania infantum in the Americas.
Autorzy:
Schwabl P; School of Life Sciences, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, G12 8QQ, Glasgow, UK. Boité MC; Laboratório de Pesquisa em Leishmaniose, Instituto Oswaldo Cruz, FIOCRUZ, 21040-365, Rio de Janeiro, Brazil. . Bussotti G; Institut Pasteur-Bioinformatics and Biostatistics Hub-C3BI, USR 3756 IP CNRS, 75015, Paris, France.; Department of Parasites and Insect Vectors, Institut Pasteur, INSERM U1201, Unité de Parasitology moléculaire et Signalisation, 75015, Paris, France. Jacobs A; School of Life Sciences, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, G12 8QQ, Glasgow, UK. Andersson B; Department of Cell and Molecular Biology, Science for Life Laboratory, Karolinska Institutet, Biomedicum 9C, 171 77, Stockholm, Sweden. Moreira O; Laboratório de Biologia Molecular e Doenças Endêmicas, Instituto Oswaldo Cruz, Fiocruz, 21040-365, Rio de Janeiro, RJ, Brazil. Freitas-Mesquita AL; Instituto de Bioquímica Médica Leopoldo de Meis (IBqM), Universidade Federal do Rio de Janeiro (UFRJ), 21941-590, Rio de Janeiro, RJ, Brazil. Meyer-Fernandes JR; Instituto de Bioquímica Médica Leopoldo de Meis (IBqM), Universidade Federal do Rio de Janeiro (UFRJ), 21941-590, Rio de Janeiro, RJ, Brazil. Telleria EL; Laboratório de Biologia Molecular de Parasitas e Vetores, Instituto Oswaldo Cruz, 21040-365, Rio de Janeiro, Brazil.; Faculty of Science, Department of Parasitology, Charles University, 128 44, Prague, Czech Republic. Traub-Csekö Y; Laboratório de Biologia Molecular de Parasitas e Vetores, Instituto Oswaldo Cruz, 21040-365, Rio de Janeiro, Brazil. Vaselek S; Faculty of Science, Department of Parasitology, Charles University, 128 44, Prague, Czech Republic. Leštinová T; Faculty of Science, Department of Parasitology, Charles University, 128 44, Prague, Czech Republic. Volf P; Faculty of Science, Department of Parasitology, Charles University, 128 44, Prague, Czech Republic. Morgado FN; Laboratório de Pesquisa em Leishmaniose, Instituto Oswaldo Cruz, FIOCRUZ, 21040-365, Rio de Janeiro, Brazil. Porrozzi R; Laboratório de Pesquisa em Leishmaniose, Instituto Oswaldo Cruz, FIOCRUZ, 21040-365, Rio de Janeiro, Brazil. Llewellyn M; School of Life Sciences, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, G12 8QQ, Glasgow, UK. SpäthGF; Department of Parasites and Insect Vectors, Institut Pasteur, INSERM U1201, Unité de Parasitology moléculaire et Signalisation, 75015, Paris, France. Cupolillo E; Laboratório de Pesquisa em Leishmaniose, Instituto Oswaldo Cruz, FIOCRUZ, 21040-365, Rio de Janeiro, Brazil.
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Źródło:
Communications biology [Commun Biol] 2021 Jan 29; Vol. 4 (1), pp. 139. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Comparative transcriptomic analysis of antimony resistant and susceptible Leishmania infantum lines.
Autorzy:
Andrade JM; Genômica Funcional de Parasitos, Instituto René Rachou, Fiocruz Minas, Belo Horizonte, MG, Brazil. Gonçalves LO; Grupo Informática de Biossistemas, Instituto René Rachou, Fiocruz Minas, Belo Horizonte, MG, Brazil.; Programa de Pós-graduação em Biologia Computacional e Sistemas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil. Liarte DB; Universidade Federal do Piauí, Teresina, PI, Brazil. Lima DA; Genômica Funcional de Parasitos, Instituto René Rachou, Fiocruz Minas, Belo Horizonte, MG, Brazil.; Grupo Informática de Biossistemas, Instituto René Rachou, Fiocruz Minas, Belo Horizonte, MG, Brazil. Guimarães FG; Grupo Informática de Biossistemas, Instituto René Rachou, Fiocruz Minas, Belo Horizonte, MG, Brazil. de Melo Resende D; Genômica Funcional de Parasitos, Instituto René Rachou, Fiocruz Minas, Belo Horizonte, MG, Brazil.; Grupo Informática de Biossistemas, Instituto René Rachou, Fiocruz Minas, Belo Horizonte, MG, Brazil. Santi AMM; Genômica Funcional de Parasitos, Instituto René Rachou, Fiocruz Minas, Belo Horizonte, MG, Brazil. de Oliveira LM; Unité Biologie des ARN des Pathogènes Fongiques, Département de Mycologie, Institut Pasteur, Paris, France. Velloso JPL; Grupo Informática de Biossistemas, Instituto René Rachou, Fiocruz Minas, Belo Horizonte, MG, Brazil. Delfino RG; Grupo Informática de Biossistemas, Instituto René Rachou, Fiocruz Minas, Belo Horizonte, MG, Brazil. Pescher P; Unité de Parasitologie moléculaire et Signalisation, Département de Parasitologie et Mycologie, Institut Pasteur, Paris, France. SpäthGF; Unité de Parasitologie moléculaire et Signalisation, Département de Parasitologie et Mycologie, Institut Pasteur, Paris, France. Ruiz JC; Grupo Informática de Biossistemas, Instituto René Rachou, Fiocruz Minas, Belo Horizonte, MG, Brazil. .; Programa de Pós-graduação em Biologia Computacional e Sistemas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil. . Murta SMF; Genômica Funcional de Parasitos, Instituto René Rachou, Fiocruz Minas, Belo Horizonte, MG, Brazil. .
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Źródło:
Parasites & vectors [Parasit Vectors] 2020 Nov 30; Vol. 13 (1), pp. 600. Date of Electronic Publication: 2020 Nov 30.
Author Correction: Discovery of novel hit compounds with broad activity against visceral and cutaneous Leishmania species by comparative phenotypic screening.
Autorzy:
Lamotte S; Institut Pasteur, Molecular Parasitology and Signaling, INSERM U1201, Department of Parasites and Insect Vectors, Paris, France. Aulner N; Institut Pasteur, UTechS Photonic BioImaging, Center for Technological Research and Resources, 75015, Paris, France. SpäthGF; Institut Pasteur, Molecular Parasitology and Signaling, INSERM U1201, Department of Parasites and Insect Vectors, Paris, France. . Prina E; Institut Pasteur, Molecular Parasitology and Signaling, INSERM U1201, Department of Parasites and Insect Vectors, Paris, France. .
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Źródło:
Scientific reports [Sci Rep] 2019 Jul 09; Vol. 9 (1), pp. 10148. Date of Electronic Publication: 2019 Jul 09.
Leishmania donovani 90 kD Heat Shock Protein - Impact of Phosphosites on Parasite Fitness, Infectivity and Casein Kinase Affinity.
Autorzy:
Hombach-Barrigah A; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. Bartsch K; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. Smirlis D; Institut Pasteur and Institut National de Santé et Recherche Médicale INSERM U1201, Unité de Parasitologie Moléculaire et Signalisation, Paris, France.; Hellenic Pasteur Institute, Athens, Greece. Rosenqvist H; Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS) University of Strathclyde, Glasgow, Scotland, UK.; Novo Nordisk A/S, Gentofte, Denmark. MacDonald A; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. Dingli F; Laboratoire de Spectrométrie de Masse Protéomique, Centre de Recherche, Institut Curie, PSL Research University, Paris, France. Loew D; Laboratoire de Spectrométrie de Masse Protéomique, Centre de Recherche, Institut Curie, PSL Research University, Paris, France. SpäthGF; Institut Pasteur and Institut National de Santé et Recherche Médicale INSERM U1201, Unité de Parasitologie Moléculaire et Signalisation, Paris, France. Rachidi N; Institut Pasteur and Institut National de Santé et Recherche Médicale INSERM U1201, Unité de Parasitologie Moléculaire et Signalisation, Paris, France. Wiese M; Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS) University of Strathclyde, Glasgow, Scotland, UK. Clos J; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2019 Mar 25; Vol. 9 (1), pp. 5074. Date of Electronic Publication: 2019 Mar 25.
Discovery of novel hit compounds with broad activity against visceral and cutaneous Leishmania species by comparative phenotypic screening.
Autorzy:
Lamotte S; Institut Pasteur, Molecular Parasitology and Signaling, INSERM U1201, Department of Parasites and Insect Vectors, Paris, France. Aulner N; Institut Pasteur, UTechS Photonic BioImaging, Center for Technological Research and Resources, 75015, Paris, France. SpäthGF; Institut Pasteur, Molecular Parasitology and Signaling, INSERM U1201, Department of Parasites and Insect Vectors, Paris, France. . Prina E; Institut Pasteur, Molecular Parasitology and Signaling, INSERM U1201, Department of Parasites and Insect Vectors, Paris, France. .
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Źródło:
Scientific reports [Sci Rep] 2019 Jan 24; Vol. 9 (1), pp. 438. Date of Electronic Publication: 2019 Jan 24.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
The enemy within: Targeting host-parasite interaction for antileishmanial drug discovery.
Autorzy:
Lamotte S; Institut Pasteur and INSERM U1201, Unité de Parasitologie Moléculaire et Signalisation, Paris, France. SpäthGF; Institut Pasteur and INSERM U1201, Unité de Parasitologie Moléculaire et Signalisation, Paris, France. Rachidi N; Institut Pasteur and INSERM U1201, Unité de Parasitologie Moléculaire et Signalisation, Paris, France. Prina E; Institut Pasteur and INSERM U1201, Unité de Parasitologie Moléculaire et Signalisation, Paris, France.
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2017 Jun 08; Vol. 11 (6), pp. e0005480. Date of Electronic Publication: 2017 Jun 08 (Print Publication: 2017).
Characterisation of Casein Kinase 1.1 in Leishmania donovani Using the CRISPR Cas9 Toolkit.
Autorzy:
Martel D; Institut Pasteur and INSERM U1201, Unité de Parasitologie Moléculaire et Signalisation, Paris, France. Beneke T; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK. Gluenz E; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK. SpäthGF; Institut Pasteur and INSERM U1201, Unité de Parasitologie Moléculaire et Signalisation, Paris, France. Rachidi N; Institut Pasteur and INSERM U1201, Unité de Parasitologie Moléculaire et Signalisation, Paris, France.
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Źródło:
BioMed research international [Biomed Res Int] 2017; Vol. 2017, pp. 4635605. Date of Electronic Publication: 2017 Nov 29.
A touch of Zen: post-translational regulation of the Leishmania stress response.
Autorzy:
SpäthGF; Institut Pasteur and Institut National de la Santé et de la Recherche Médicale U1210, Unité de Parasitologie Moléculaire et Signalisation, 25 rue du Dr Roux, Paris, 75015, France. Drini S Rachidi N
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Źródło:
Cellular microbiology [Cell Microbiol] 2015 May; Vol. 17 (5), pp. 632-8. Date of Electronic Publication: 2015 Apr 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability.
Autorzy:
Cayla M; Institut Pasteur and Centre National de la Recherche Scientifique URA 2581, Unité de Parasitologie Moléculaire et Signalisation, Paris, France. Rachidi N; Institut Pasteur and Centre National de la Recherche Scientifique URA 2581, Unité de Parasitologie Moléculaire et Signalisation, Paris, France. Leclercq O; Institut Pasteur and Centre National de la Recherche Scientifique URA 2581, Unité de Parasitologie Moléculaire et Signalisation, Paris, France. Schmidt-Arras D; Institut Pasteur and Centre National de la Recherche Scientifique URA 2581, Unité de Parasitologie Moléculaire et Signalisation, Paris, France. Rosenqvist H; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland; Protein Research Group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark. Wiese M; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland. SpäthGF; Institut Pasteur and Centre National de la Recherche Scientifique URA 2581, Unité de Parasitologie Moléculaire et Signalisation, Paris, France.
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Źródło:
PLoS pathogens [PLoS Pathog] 2014 Sep 18; Vol. 10 (9), pp. e1004347. Date of Electronic Publication: 2014 Sep 18 (Print Publication: 2014).
Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferation.
Autorzy:
Pescher P; Laboratory of Parasite Virulence Trypanosome Cell Biology Unit, Institut Pasteur, CNRS URA 2581/Institut National de la Santé et de la Recherche Médicale AVENIR Program, Paris, France. Blisnick T Bastin P SpäthGF
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Źródło:
Cellular microbiology [Cell Microbiol] 2011 Jul; Vol. 13 (7), pp. 978-91. Date of Electronic Publication: 2011 Apr 26.
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