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Wyszukujesz frazę ""Sphingolipids"" wg kryterium: Temat


Tytuł :
The Role of Sphingolipids in Cancer Immunotherapy.
Autorzy :
Giussani P; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, LITA Segrate, Via Fratelli Cervi, 93, 20090 Segrate, Italy.
Prinetti A; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, LITA Segrate, Via Fratelli Cervi, 93, 20090 Segrate, Italy.
Tringali C; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, LITA Segrate, Via Fratelli Cervi, 93, 20090 Segrate, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 17; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Immunomodulation*
Neoplasms/*immunology
Neoplasms/*metabolism
Sphingolipids/*metabolism
Animals ; Antigens, Neoplasm/immunology ; Cell Communication ; Disease Management ; Disease Susceptibility ; Humans ; Immune System/immunology ; Immune System/metabolism ; Immunotherapy/adverse effects ; Immunotherapy/methods ; Immunotherapy, Adoptive/adverse effects ; Immunotherapy, Adoptive/methods ; Lysophospholipids/metabolism ; Neoplasms/therapy ; Signal Transduction ; Sphingolipids/chemistry ; Sphingolipids/immunology ; Sphingosine/analogs & derivatives ; Sphingosine/metabolism ; Treatment Outcome
Czasopismo naukowe
Tytuł :
A Comprehensive Review: Sphingolipid Metabolism and Implications of Disruption in Sphingolipid Homeostasis.
Autorzy :
Quinville BM; Centre for Neuroscience Studies at Queen's University, Kingston, ON K7L 3N6, Canada.
Deschenes NM; Centre for Neuroscience Studies at Queen's University, Kingston, ON K7L 3N6, Canada.
Ryckman AE; Centre for Neuroscience Studies at Queen's University, Kingston, ON K7L 3N6, Canada.
Walia JS; Centre for Neuroscience Studies at Queen's University, Kingston, ON K7L 3N6, Canada.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 28; Vol. 22 (11). Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Homeostasis*
Cell Membrane/*metabolism
Membrane Lipids/*metabolism
Sphingolipids/*metabolism
Animals ; Cell Membrane/chemistry ; Humans ; Inflammation/metabolism ; Membrane Lipids/chemical synthesis ; Membrane Lipids/chemistry ; Models, Chemical ; Molecular Structure ; Neoplasms/metabolism ; Sphingolipids/chemical synthesis ; Sphingolipids/chemistry
Czasopismo naukowe
Tytuł :
Sphingolipids mediate polar sorting of PIN2 through phosphoinositide consumption at the trans-Golgi network.
Autorzy :
Ito Y; Laboratoire de Biogenèse Membranaire, Univ. Bordeaux, Villenave d'Ornon, France.
Esnay N; Laboratoire de Biogenèse Membranaire, Univ. Bordeaux, Villenave d'Ornon, France.; BioDiscovery Institute and Department of Biological Sciences, University of North Texas, Denton, TX, USA.
Platre MP; Laboratoire Reproduction et Développement des Plantes, Université de Lyon, ENS de Lyon, UCB Lyon1, CNRS, INRAE, Lyon, France.; Plant Molecular and Cellular Biology Laboratory and Integrative Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Wattelet-Boyer V; Laboratoire de Biogenèse Membranaire, Univ. Bordeaux, Villenave d'Ornon, France.
Noack LC; Laboratoire Reproduction et Développement des Plantes, Université de Lyon, ENS de Lyon, UCB Lyon1, CNRS, INRAE, Lyon, France.
Fougère L; Laboratoire de Biogenèse Membranaire, Univ. Bordeaux, Villenave d'Ornon, France.
Menzel W; Laboratoire de Biogenèse Membranaire, Univ. Bordeaux, Villenave d'Ornon, France.; Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany.
Claverol S; Platforme Proteome, Univ. Bordeaux, Bordeaux, France.
Fouillen L; Laboratoire de Biogenèse Membranaire, Univ. Bordeaux, Villenave d'Ornon, France.; MetaboHub-Bordeaux Metabolome INRAE, Villenave d'Ornon, France.
Moreau P; Laboratoire de Biogenèse Membranaire, Univ. Bordeaux, Villenave d'Ornon, France.; Bordeaux Imaging Centre, Plant Imaging Platform, UMS 3420 University of Bordeaux-CNRS, INRAE, Villenave-d'Ornon Cedex, France.
Jaillais Y; Laboratoire Reproduction et Développement des Plantes, Université de Lyon, ENS de Lyon, UCB Lyon1, CNRS, INRAE, Lyon, France.
Boutté Y; Laboratoire de Biogenèse Membranaire, Univ. Bordeaux, Villenave d'Ornon, France. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 13; Vol. 12 (1), pp. 4267. Date of Electronic Publication: 2021 Jul 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Phosphatidylinositols/*metabolism
Sphingolipids/*metabolism
trans-Golgi Network/*metabolism
Animals ; Endoplasmic Reticulum/metabolism ; Humans ; Phosphatidylinositols/genetics ; Sphingolipids/genetics ; Type C Phospholipases/metabolism ; trans-Golgi Network/genetics
Czasopismo naukowe
Tytuł :
Sphingolipid long-chain base hydroxylation influences plant growth and callose deposition in Physcomitrium patens.
Autorzy :
Gömann J; Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen, Göttingen, D-37077, Germany.
Herrfurth C; Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen, Göttingen, D-37077, Germany.; Service Unit for Metabolomics and Lipidomics, Göttingen Center for Molecular Biosciences (GZMB), University of Göttingen, Göttingen, D-37077, Germany.
Zienkiewicz A; Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen, Göttingen, D-37077, Germany.
Ischebeck T; Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen, Göttingen, D-37077, Germany.; Department of Plant Biochemistry, Göttingen Center for Molecular Biosciences (GZMB), University of Göttingen, Göttingen, D-37077, Germany.
Haslam TM; Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen, Göttingen, D-37077, Germany.
Hornung E; Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen, Göttingen, D-37077, Germany.
Feussner I; Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen, Göttingen, D-37077, Germany.; Service Unit for Metabolomics and Lipidomics, Göttingen Center for Molecular Biosciences (GZMB), University of Göttingen, Göttingen, D-37077, Germany.; Department of Plant Biochemistry, Göttingen Center for Molecular Biosciences (GZMB), University of Göttingen, Göttingen, D-37077, Germany.
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Źródło :
The New phytologist [New Phytol] 2021 Jul; Vol. 231 (1), pp. 297-314. Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bryopsida*
Sphingolipids*
Glucans ; Hydroxylation
Czasopismo naukowe
Tytuł :
Altered hepatic sphingolipid metabolism in insulin resistant mice: Role of advanced glycation endproducts.
Autorzy :
Mastrocola R; Dept. of Clinical and Biological Sciences, University of Turin, Italy; Dept. of Internal Medicine, MUMC+, Maastricht, Limburg, Cardiovascular Research Institute, Maastricht (CARIM), the Netherlands. Electronic address: .
Dal Bello F; Dept. of Molecular Biotechnology and Health Sciences, University of Turin, Italy.
Cento AS; Dept. of Clinical and Biological Sciences, University of Turin, Italy.
Gaens K; Dept. of Internal Medicine, MUMC+, Maastricht, Limburg, Cardiovascular Research Institute, Maastricht (CARIM), the Netherlands.
Collotta D; Dept. of Drug Science and Technology, University of Turin, Italy.
Aragno M; Dept. of Clinical and Biological Sciences, University of Turin, Italy.
Medana C; Dept. of Molecular Biotechnology and Health Sciences, University of Turin, Italy.
Collino M; Dept. of Drug Science and Technology, University of Turin, Italy.
Wouters K; Dept. of Internal Medicine, MUMC+, Maastricht, Limburg, Cardiovascular Research Institute, Maastricht (CARIM), the Netherlands.
Schalkwijk CG; Dept. of Internal Medicine, MUMC+, Maastricht, Limburg, Cardiovascular Research Institute, Maastricht (CARIM), the Netherlands.
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Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2021 Jun; Vol. 169, pp. 425-435. Date of Electronic Publication: 2021 Apr 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Insulin*
Sphingolipids*
Animals ; Glycation End Products, Advanced ; Liver ; Mice ; Mice, Inbred C57BL ; Receptor for Advanced Glycation End Products/genetics ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Ether lipids, sphingolipids and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients.
Autorzy :
Hannich JT; Department of Biochemistry, Faculty of Science, NCCR Chemical Biology, University of Geneva, Geneva, Switzerland.
Loizides-Mangold U; Division of Endocrinology, Diabetes, Nutrition and Patient Education, Department of Medicine, University Hospital of Geneva, Geneva, Switzerland.; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland.
Sinturel F; Division of Endocrinology, Diabetes, Nutrition and Patient Education, Department of Medicine, University Hospital of Geneva, Geneva, Switzerland.; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland.
Harayama T; Department of Biochemistry, Faculty of Science, NCCR Chemical Biology, University of Geneva, Geneva, Switzerland.
Vandereycken B; Department of Mathematics, University of Geneva, Geneva, Switzerland.
Saini C; Department and Division of Primary Care Medicine, University Hospital of Geneva, Geneva, Switzerland.
Gosselin P; Division of Endocrinology, Diabetes, Nutrition and Patient Education, Department of Medicine, University Hospital of Geneva, Geneva, Switzerland.; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland.; Department and Division of Primary Care Medicine, University Hospital of Geneva, Geneva, Switzerland.
Brulhart-Meynet MC; Division of Endocrinology, Diabetes, Nutrition and Patient Education, Department of Medicine, University Hospital of Geneva, Geneva, Switzerland.
Robert M; Department of Digestive and Bariatric Surgery, Edouard Herriot University Hospital, University, Lyon, France.
Chanon S; CarMeN Laboratory, INSERM U1060, INRA 1397, University Lyon 1, Oullins, France.
Durand C; CarMeN Laboratory, INSERM U1060, INRA 1397, University Lyon 1, Oullins, France.
Paz Montoya J; Proteomics Core Facility, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
David FPA; Gene Expression Core Facility, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Guessous I; Department and Division of Primary Care Medicine, University Hospital of Geneva, Geneva, Switzerland.
Pataky Z; Division of Endocrinology, Diabetes, Nutrition and Patient Education, Department of Medicine, WHO Collaborating Centre, University Hospital of Geneva, University of Geneva, Geneva, Switzerland.
Golay A; Division of Endocrinology, Diabetes, Nutrition and Patient Education, Department of Medicine, WHO Collaborating Centre, University Hospital of Geneva, University of Geneva, Geneva, Switzerland.
Jornayvaz FR; Division of Endocrinology, Diabetes, Nutrition and Patient Education, Department of Medicine, University Hospital of Geneva, Geneva, Switzerland.; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Philippe J; Division of Endocrinology, Diabetes, Nutrition and Patient Education, Department of Medicine, University Hospital of Geneva, Geneva, Switzerland.; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Dermitzakis ET; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland.; Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Brown SA; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Lefai E; INRA, Unité de Nutrition Humaine, Université Clermont Auvergne, Paris, France.
Riezman H; Department of Biochemistry, Faculty of Science, NCCR Chemical Biology, University of Geneva, Geneva, Switzerland.
Dibner C; Division of Endocrinology, Diabetes, Nutrition and Patient Education, Department of Medicine, University Hospital of Geneva, Geneva, Switzerland.; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland.
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Źródło :
Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2021 May; Vol. 232 (1), pp. e13610. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Type 2*
Sphingolipids*
Adipose Tissue/physiology ; Animals ; Ether ; Humans ; Lipids/chemistry ; Mice ; Obesity
Czasopismo naukowe
Tytuł :
Screening of lipid metabolism biomarkers in patients with coronary heart disease via ultra-performance liquid chromatography-high resolution mass spectrometry.
Autorzy :
Cai F; Faculty of Agriculture and Food Science, Kunming University of Science and Technology, Yunnan, Kunming 650500, China.
Ren F; Faculty of Agriculture and Food Science, Kunming University of Science and Technology, Yunnan, Kunming 650500, China.
Zhang Y; Department of Cardiology, Yunnan First People's Hospital, Kunming 650032, China.
Ding X; Department of Cardiology, Yunnan First People's Hospital, Kunming 650032, China.
Fu G; School of Science, Kunming University of Science and Technology, Yunnan, Kunming 650500, China.
Ren D; Faculty of Agriculture and Food Science, Kunming University of Science and Technology, Yunnan, Kunming 650500, China.
Yang L; Faculty of Agriculture and Food Science, Kunming University of Science and Technology, Yunnan, Kunming 650500, China.
Chen N; Faculty of Agriculture and Food Science, Kunming University of Science and Technology, Yunnan, Kunming 650500, China.
Shang Y; Faculty of Agriculture and Food Science, Kunming University of Science and Technology, Yunnan, Kunming 650500, China.
Hu Y; Faculty of Agriculture and Food Science, Kunming University of Science and Technology, Yunnan, Kunming 650500, China.
Yi L; Faculty of Agriculture and Food Science, Kunming University of Science and Technology, Yunnan, Kunming 650500, China. Electronic address: .
Zhang H; Department of Cardiology, Yunnan First People's Hospital, Kunming 650032, China. Electronic address: .
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Źródło :
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2021 Apr 15; Vol. 1169, pp. 122603. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article
MeSH Terms :
Glycerophospholipids*/blood
Glycerophospholipids*/metabolism
Sphingolipids*/blood
Sphingolipids*/metabolism
Chromatography, High Pressure Liquid/*methods
Coronary Disease/*metabolism
Lipid Metabolism/*physiology
Aged ; Biomarkers/blood ; Biomarkers/metabolism ; Case-Control Studies ; Female ; High-Throughput Screening Assays ; Humans ; Lipidomics ; Male ; Mass Spectrometry/methods ; Middle Aged
Czasopismo naukowe
Tytuł :
Metabolic Depletion of Sphingolipids Reduces Cell Surface Population of the Human Serotonin 1A Receptor due to Impaired Trafficking.
Autorzy :
Kumar A; CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India.; Amity Institute of Biotechnology, Amity University Haryana, Amity Education Valley, Gurugram 122 413, India.
Sarkar P; CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India.
Chattopadhyay A; CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Apr 07; Vol. 12 (7), pp. 1189-1196. Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Serotonin*
Sphingolipids*
Cell Membrane ; HEK293 Cells ; Humans ; Receptor, Serotonin, 5-HT1A
Czasopismo naukowe
Tytuł :
How the replacement of cholesterol by 25-hydroxycholesterol affects the interactions with sphingolipids: The Langmuir Monolayer Study complemented with theoretical calculations.
Autorzy :
Kobierski J; Department of Pharmaceutical Biophysics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
Wnętrzak A; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland.
Chachaj-Brekiesz A; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland.
Filiczkowska A; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.
Petelska AD; Faculty of Chemistry, University of Bialystok, Ciołkowskiego 1 K, 15-425 Bialystok, Poland.
Dynarowicz-Latka P; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland.
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Źródło :
Journal of the Royal Society, Interface [J R Soc Interface] 2021 Mar; Vol. 18 (176), pp. 20210050. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hydroxycholesterols*
Sphingolipids*
Cholesterol ; Sphingomyelins ; Surface Properties
Czasopismo naukowe
Tytuł :
HILIC-MS-based metabolomics reveal that Astragalus polysaccharide alleviates doxorubicin-induced cardiomyopathy by regulating sphingolipid and glycerophospholipid homeostasis.
Autorzy :
Zhang Y; School of Pharmacy, Air Force Medical University, Xi'an, 710032, China. Electronic address: .
Zhou Q; Department of Traditional Chinese Medicine, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China. Electronic address: .
Ding X; School of Pharmacy, Air Force Medical University, Xi'an, 710032, China; School of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, 712046, China. Electronic address: .
Wang H; School of Pharmacy, Air Force Medical University, Xi'an, 710032, China. Electronic address: .
Tan G; School of Pharmacy, Air Force Medical University, Xi'an, 710032, China. Electronic address: .
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Źródło :
Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2021 Sep 05; Vol. 203, pp. 114177. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
Cardiomyopathies*/chemically induced
Sphingolipids*
Animals ; Biomarkers ; Doxorubicin/toxicity ; Glycerophospholipids ; Homeostasis ; Metabolomics ; Polysaccharides/pharmacology
Czasopismo naukowe
Tytuł :
More Evidence for Inborn Dysregulation of Sphingolipid Metabolism in Children with Asthma?
Autorzy :
Ono JG; Department of Pediatrics Weill Cornell Medicine New York, New York.
Worgall S; Department of Pediatrics Department of Genetic Medicine and.; Drukier Institute for Children's Health Weill Cornell Medicine New York, New York.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2021 Apr 01; Vol. 203 (7), pp. 792-793.
Typ publikacji :
Editorial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Asthma*
Sphingolipids*
Child ; Humans ; Lipid Metabolism
Raport
Tytuł :
Azidosphinganine enables metabolic labeling and detection of sphingolipid de novo synthesis.
Autorzy :
Fink J; Institute of Organic Chemistry, Julius-Maximilians University Würzburg, Am Hubland C1, 97074 Würzburg, Germany. .
Schumacher F; Institute of Pharmacy, Freie Universität Berlin, Königin-Luise-Str. 2+4, 14195 Berlin, Germany. , Department of Toxicology, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
Schlegel J; Department of Biotechnology and Biophysics, Biocenter, Julius-Maximilians University Würzburg, 97074 Würzburg, Germany. .
Stenzel P; Institute of Organic Chemistry, Julius-Maximilians University Würzburg, Am Hubland C1, 97074 Würzburg, Germany. .
Wigger D; Institute of Nutritional Science, Department of Toxicology, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
Sauer M; Department of Biotechnology and Biophysics, Biocenter, Julius-Maximilians University Würzburg, 97074 Würzburg, Germany. .
Kleuser B; Institute of Pharmacy, Freie Universität Berlin, Königin-Luise-Str. 2+4, 14195 Berlin, Germany. , Department of Toxicology, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
Seibel J; Institute of Organic Chemistry, Julius-Maximilians University Würzburg, Am Hubland C1, 97074 Würzburg, Germany. .
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Źródło :
Organic & biomolecular chemistry [Org Biomol Chem] 2021 Mar 18; Vol. 19 (10), pp. 2203-2212.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Azides/*metabolism
Sphingolipids/*analysis
Sphingosine/*analogs & derivatives
Sphingosine/*metabolism
Animals ; Azides/chemical synthesis ; Boron Compounds/chemical synthesis ; Boron Compounds/metabolism ; Cell Line, Tumor ; Chlorocebus aethiops ; Click Chemistry ; Endoplasmic Reticulum/metabolism ; Fluorescent Dyes/chemical synthesis ; Fluorescent Dyes/metabolism ; Humans ; Microscopy, Confocal ; Microscopy, Fluorescence ; Sphingolipids/biosynthesis
Czasopismo naukowe
Tytuł :
Kicking off sphingolipid biosynthesis: structures of the serine palmitoyltransferase complex.
Autorzy :
Wattenberg BW; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Mar; Vol. 28 (3), pp. 229-231.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Serine C-Palmitoyltransferase/*chemistry
Serine C-Palmitoyltransferase/*metabolism
Sphingolipids/*biosynthesis
Humans ; Models, Molecular ; Sphingolipids/metabolism
Czasopismo naukowe
Tytuł :
Aortic Gene Expression Profiles Show How ApoA-I Levels Modulate Inflammation, Lysosomal Activity, and Sphingolipid Metabolism in Murine Atherosclerosis.
Autorzy :
Busnelli M; Department of Pharmacological and Biomolecular Sciences (M.B., S.M., A.C., F.F., R.O., S.B., G.C.), Università degli Studi di Milano, Italy.
Manzini S; Department of Pharmacological and Biomolecular Sciences (M.B., S.M., A.C., F.F., R.O., S.B., G.C.), Università degli Studi di Milano, Italy.
Chiara M; Department of Biosciences (M.C., D.H.), Università degli Studi di Milano, Italy.; Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council, Bari, Italy (M.C., D.H.).
Colombo A; Department of Pharmacological and Biomolecular Sciences (M.B., S.M., A.C., F.F., R.O., S.B., G.C.), Università degli Studi di Milano, Italy.
Fontana F; Department of Pharmacological and Biomolecular Sciences (M.B., S.M., A.C., F.F., R.O., S.B., G.C.), Università degli Studi di Milano, Italy.
Oleari R; Department of Pharmacological and Biomolecular Sciences (M.B., S.M., A.C., F.F., R.O., S.B., G.C.), Università degli Studi di Milano, Italy.
Potì F; Department of Medicine and Surgery-Unit of Neurosciences, University of Parma, Italy (F.P.).
Horner D; Department of Biosciences (M.C., D.H.), Università degli Studi di Milano, Italy.; Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council, Bari, Italy (M.C., D.H.).
Bellosta S; Department of Pharmacological and Biomolecular Sciences (M.B., S.M., A.C., F.F., R.O., S.B., G.C.), Università degli Studi di Milano, Italy.
Chiesa G; Department of Pharmacological and Biomolecular Sciences (M.B., S.M., A.C., F.F., R.O., S.B., G.C.), Università degli Studi di Milano, Italy.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Feb; Vol. 41 (2), pp. 651-667. Date of Electronic Publication: 2020 Dec 17.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcriptome*
Aorta/*metabolism
Aortic Diseases/*genetics
Apolipoprotein A-I/*metabolism
Atherosclerosis/*genetics
Inflammation/*genetics
Lysosomes/*genetics
Sphingolipids/*metabolism
Animals ; Aorta/pathology ; Aortic Diseases/metabolism ; Aortic Diseases/pathology ; Apolipoprotein A-I/blood ; Apolipoprotein A-I/genetics ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Cells, Cultured ; Cholesterol/blood ; Diet, High-Fat ; Disease Models, Animal ; Gene Expression Profiling ; Gene Regulatory Networks ; High-Throughput Nucleotide Sequencing ; Inflammation/metabolism ; Inflammation/pathology ; Lysosomes/metabolism ; Lysosomes/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout, ApoE ; Plaque, Atherosclerotic ; Protein Interaction Maps ; Signal Transduction ; Sphingolipids/blood ; Time Factors ; Triglycerides/blood
Czasopismo naukowe
Tytuł :
Dissecting the regulatory roles of ORM proteins in the sphingolipid pathway of plants.
Autorzy :
Alsiyabi A; Department of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, United States of America.
Solis AG; Center for Plant Science Innovation & Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, United States of America.
Cahoon EB; Center for Plant Science Innovation & Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, United States of America.
Saha R; Department of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, United States of America.; Center for Plant Science Innovation, University of Nebraska-Lincoln, Lincoln, Nebraska, United States of America.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2021 Jan 28; Vol. 17 (1), pp. e1008284. Date of Electronic Publication: 2021 Jan 28 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Arabidopsis Proteins*/genetics
Arabidopsis Proteins*/metabolism
Orosomucoid*/genetics
Orosomucoid*/metabolism
Sphingolipids*/genetics
Sphingolipids*/metabolism
Gene Expression Regulation, Plant/*genetics
Arabidopsis/genetics ; Arabidopsis/metabolism ; Ceramides/genetics ; Ceramides/metabolism ; Computational Biology ; Metabolic Networks and Pathways/genetics ; Models, Biological ; Seedlings/genetics ; Seedlings/metabolism
Czasopismo naukowe
Tytuł :
Rotten to the Cortex: Ceramide-Mediated Lipotoxicity in Diabetic Kidney Disease.
Autorzy :
Nicholson RJ; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, United States.; Diabetes and Metabolism Research Center, University of Utah School of Medicine, Salt Lake City, UT, United States.
Pezzolesi MG; Diabetes and Metabolism Research Center, University of Utah School of Medicine, Salt Lake City, UT, United States.; Division of Nephrology and Hypertension, Department of Internal Medicine, University of Utah, Salt Lake City, UT, United States.
Summers SA; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, United States.; Diabetes and Metabolism Research Center, University of Utah School of Medicine, Salt Lake City, UT, United States.
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Źródło :
Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2021 Jan 28; Vol. 11, pp. 622692. Date of Electronic Publication: 2021 Jan 28 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Ceramides/*metabolism
Diabetic Nephropathies/*drug therapy
Diabetic Nephropathies/*metabolism
Insulin Resistance/*physiology
Kidney Cortex/*metabolism
Sphingolipids/*metabolism
Animals ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/pathology ; Diabetic Nephropathies/pathology ; Humans ; Kidney Cortex/drug effects ; Kidney Cortex/pathology ; Sphingolipids/toxicity
Czasopismo naukowe
Tytuł :
Consistent alteration of chain length-specific ceramides in human and mouse fibrotic kidneys.
Autorzy :
Eckes T; Institute of General Pharmacology and Toxicology, University Hospital, Goethe University Frankfurt am Main, Germany. Electronic address: .
Trautmann S; Institute of Clinical Pharmacology, University Hospital, Goethe University Frankfurt am Main, Germany.
Djudjaj S; Institute of Pathology, University Hospital of the RWTH Aachen, Germany.
Beyer S; Institute of General Pharmacology and Toxicology, University Hospital, Goethe University Frankfurt am Main, Germany.
Patyna S; Department of Nephrology, University Hospital, Goethe University Frankfurt am Main, Germany.
Schwalm S; Institute of General Pharmacology and Toxicology, University Hospital, Goethe University Frankfurt am Main, Germany.
Gauer S; Department of Nephrology, University Hospital, Goethe University Frankfurt am Main, Germany.
Thomas D; Institute of Clinical Pharmacology, University Hospital, Goethe University Frankfurt am Main, Germany.
Schaefer L; Institute of General Pharmacology and Toxicology, University Hospital, Goethe University Frankfurt am Main, Germany.
Boor P; Institute of Pathology, University Hospital of the RWTH Aachen, Germany; Division of Nephrology, University Hospital of the RWTH Aachen, Germany.
Koch A; Institute of General Pharmacology and Toxicology, University Hospital, Goethe University Frankfurt am Main, Germany.
Pfeilschifter J; Institute of General Pharmacology and Toxicology, University Hospital, Goethe University Frankfurt am Main, Germany.
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Źródło :
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2021 Jan; Vol. 1866 (1), pp. 158821. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ceramides/*metabolism
Hydronephrosis/*metabolism
Pyelonephritis/*metabolism
Sphingolipids/*metabolism
Ureteral Obstruction/*metabolism
Actins/genetics ; Actins/metabolism ; Adenine/administration & dosage ; Aged ; Animals ; Biomarkers/metabolism ; Ceramides/classification ; Collagen Type I/genetics ; Collagen Type I/metabolism ; Collagen Type III/genetics ; Collagen Type III/metabolism ; Disease Models, Animal ; Female ; Fibrosis ; Gene Expression Regulation ; Humans ; Hydronephrosis/chemically induced ; Hydronephrosis/genetics ; Hydronephrosis/pathology ; Kidney/metabolism ; Kidney/pathology ; Lipid Metabolism/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Pyelonephritis/chemically induced ; Pyelonephritis/genetics ; Pyelonephritis/pathology ; Sphingolipids/classification ; Ureteral Obstruction/genetics ; Ureteral Obstruction/pathology
Czasopismo naukowe
Tytuł :
Sphingolipids in food and their critical roles in human health.
Autorzy :
Wang X; College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong, China.
Wang Y; College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong, China.; Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong, China.
Xu J; College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong, China.
Xue C; College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong, China.; Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong, China.
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Źródło :
Critical reviews in food science and nutrition [Crit Rev Food Sci Nutr] 2021; Vol. 61 (3), pp. 462-491. Date of Electronic Publication: 2020 Mar 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Neoplasms*
Sphingolipids*
Humans ; Signal Transduction
Czasopismo naukowe
Tytuł :
ORMDL3 and Asthma: Linking Sphingolipid Regulation to Altered T Cell Function.
Autorzy :
Luthers CR; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Dunn TM; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.; Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Snow AL; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Nov 30; Vol. 11, pp. 597945. Date of Electronic Publication: 2020 Nov 30 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Disease Susceptibility*
Asthma/*etiology
Asthma/*metabolism
Membrane Proteins/*genetics
Sphingolipids/*metabolism
T-Lymphocytes/*immunology
T-Lymphocytes/*metabolism
Allergens/immunology ; Endoplasmic Reticulum Stress ; Energy Metabolism ; Gene Expression Regulation ; Humans ; Immunomodulation ; Lymphocyte Activation/immunology ; Membrane Proteins/metabolism ; Sphingolipids/immunology
Czasopismo naukowe
Tytuł :
Effects of constant light exposure on sphingolipidomics and progression of NASH in high-fat-fed rats.
Autorzy :
Yue F; Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xia K; Department of Cardiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wei L; Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xing L; Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wu S; Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shi Y; Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lam SM; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Shui G; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Xiang X; Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Russell R; Department of Health and Human Performance, College of Health Professions, University of Texas Rio Grande Valley, Brownsville, Texas, USA.
Zhang D; Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
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Źródło :
Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2020 Nov; Vol. 35 (11), pp. 1978-1989. Date of Electronic Publication: 2020 Feb 23.
Typ publikacji :
Journal Article
MeSH Terms :
Diet, High-Fat/*adverse effects
Environmental Exposure/*adverse effects
Light/*adverse effects
Liver/*metabolism
Non-alcoholic Fatty Liver Disease/*etiology
Sphingolipids/*metabolism
Animals ; Blood Glucose/metabolism ; Ceramides/blood ; Ceramides/metabolism ; Darkness ; Disease Progression ; Dyslipidemias/etiology ; Lipidomics/methods ; Male ; Rats, Sprague-Dawley ; Risk Factors ; Sphingolipids/blood
Czasopismo naukowe

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