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Tytuł:
HIV-1 Infection Results in Sphingosine-1-Phosphate Receptor 1 Dysregulation in the Human Thymus.
Autorzy:
Resop RS; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA.; UCLA AIDS Institute and Center for AIDS Research, University of California, Los Angeles, CA 90095, USA.
Salvatore B; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA.
Kim SJ; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA.
Gordon BR; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA.
Blom B; Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Vatakis DN; UCLA AIDS Institute and Center for AIDS Research, University of California, Los Angeles, CA 90095, USA.; Department of Medicine, Division of Hematology-Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Uittenbogaart CH; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA.; UCLA AIDS Institute and Center for AIDS Research, University of California, Los Angeles, CA 90095, USA.; Department of Pediatrics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Sep 08; Vol. 24 (18). Date of Electronic Publication: 2023 Sep 08.
Typ publikacji:
Journal Article
MeSH Terms:
HIV Infections*/metabolism
Sphingosine-1-Phosphate Receptors*/metabolism
Thymus Gland*
Animals ; Humans ; Mice ; HIV-1 ; Lysophospholipids/metabolism ; Thymocytes/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways.
Autorzy:
Gurrea-Rubio M; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Wang Q; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Autoimmunity Center of Excellence, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Mills EA; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Wu Q; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Pitt D; Department of Neurology, Yale Medicine, New Haven, CT 06473, USA.
Tsou PS; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.; Autoimmunity Center of Excellence, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Fox DA; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.; Autoimmunity Center of Excellence, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Mao-Draayer Y; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Autoimmunity Center of Excellence, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Multiple Sclerosis Center of Excellence, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 20; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 20.
Typ publikacji:
Journal Article
MeSH Terms:
Neuroprotective Agents*/pharmacology
Multiple Sclerosis*/drug therapy
Multiple Sclerosis, Chronic Progressive*/drug therapy
Azetidines*
Benzyl Compounds*
Humans ; Animals ; Rats ; Sphingosine-1-Phosphate Receptors ; Neuroinflammatory Diseases ; Tumor Necrosis Factor-alpha/therapeutic use ; Cell Death
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720.
Autorzy:
Laroche FJF; Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA.
Li S; Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA.; Institute of Agro-Bioengineering and College of Life Sciences, Guizhou University, Guizhou 550025, China.
Shen N; Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA.
Hwang SK; Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA.
Nguyen G; Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA.
Yu W; Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA.
Wong CK; Biomedical Genetics Section, Department of Medicine, Department of Pathology and Laboratory Medicine, Genetics and Genomics Graduate Program, Cancer Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA.
Quinton RJ; Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA.
Berman JN; Children's Hospital of Eastern Ontario Research Institute, Departments of Pediatrics and Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8L1, Canada.
Liu CT; Department of Biostatistics, School of Public Health, Boston University, Boston, MA 02118, USA.
Singh A; Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA.
Ganem NJ; Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA.
Thiagalingam S; Biomedical Genetics Section, Department of Medicine, Department of Pathology and Laboratory Medicine, Genetics and Genomics Graduate Program, Cancer Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA.
Feng H; Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA.
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Źródło:
Cells [Cells] 2023 Mar 23; Vol. 12 (7). Date of Electronic Publication: 2023 Mar 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Fingolimod Hydrochloride*/pharmacology
Sphingosine-1-Phosphate Receptors*/metabolism
Triple Negative Breast Neoplasms*/drug therapy
Animals ; Humans ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Lysosphingolipid/metabolism ; Threonine ; Zebrafish/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dialogue between VE-Cadherin and Sphingosine 1 Phosphate Receptor1 (S1PR1) for Protecting Endothelial Functions.
Autorzy:
Garnier O; University Grenoble Alpes, INSERM U13, CEA, BGE-Biomics, 38000 Grenoble, France.
Vilgrain I; University Grenoble Alpes, INSERM U13, CEA, BGE-Biomics, 38000 Grenoble, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 16; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 16.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cadherins*/metabolism
Endothelial Cells*/metabolism
Endothelium, Vascular*/metabolism
Sphingosine-1-Phosphate Receptors*/metabolism
Humans ; Adherens Junctions/metabolism ; Capillary Permeability/physiology ; Sphingosine/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
LncRNA ANRIL-mediated miR-181b-5p/S1PR1 axis is involved in the progression of uremic cardiomyopathy through activating T cells.
Autorzy:
Xu Y; Urology and Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, China.
Cao L; Urology and Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, China.
Ji S; Urology and Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, China.
Shen W; Urology and Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, China. .
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Źródło:
Scientific reports [Sci Rep] 2022 Oct 27; Vol. 12 (1), pp. 18027. Date of Electronic Publication: 2022 Oct 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cardiomyopathies*/pathology
MicroRNAs*/genetics
MicroRNAs*/metabolism
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
T-Lymphocytes*/metabolism
Sphingosine-1-Phosphate Receptors*/genetics
Sphingosine-1-Phosphate Receptors*/metabolism
Animals ; Mice ; Body Weight ; Cell Line ; Fibrosis ; Inflammation/pathology ; Tumor Necrosis Factor-alpha
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis.
Autorzy:
Liu XT; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, Sydney, NSW, 2050, Australia.
Huang Y; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, Sydney, NSW, 2050, Australia.
Liu D; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, Sydney, NSW, 2050, Australia.
Jiang YC; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, Sydney, NSW, 2050, Australia.
Zhao M; School of Science, Technology and Engineering, University of the Sunshine Coast, Maroochydore DC, QLD, 4558, Australia.
Chung LH; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, Sydney, NSW, 2050, Australia.
Han XD; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, Sydney, NSW, 2050, Australia.
Zhao Y; Key Laboratory of Biotechnology and Bioresources Utilization of Ministry of Education, Dalian Minzu University, Dalian, 116600, Liaoning, China.
Chen J; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, Sydney, NSW, 2050, Australia.
Coleman P; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, Sydney, NSW, 2050, Australia.
Ting KK; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, Sydney, NSW, 2050, Australia.
Tran C; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia.
Su Y; Sydney Microscopy and Microanalysis, The University of Sydney, Sydney, NSW, 2006, Australia.
Dennis CV; AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, NSW, 2050, Australia.
Bhatnagar A; Sydney Mass Spectrometry, The University of Sydney, Sydney, NSW, 2006, Australia.
Liu K; AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, NSW, 2050, Australia.
Don AS; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia.
Vadas MA; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, Sydney, NSW, 2050, Australia.
Gorrell MD; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, Sydney, NSW, 2050, Australia.; AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, NSW, 2050, Australia.
Zhang S; Key Laboratory of Biotechnology and Bioresources Utilization of Ministry of Education, Dalian Minzu University, Dalian, 116600, Liaoning, China.
Murray M; Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia.
Kavurma MM; Heart Research Institute, Sydney, NSW, 2042, Australia.
McCaughan GW; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, Sydney, NSW, 2050, Australia.; AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, NSW, 2050, Australia.
Gamble JR; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, Sydney, NSW, 2050, Australia.
Qi Y; Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, Sydney, NSW, 2050, Australia. .
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Źródło:
Journal of translational medicine [J Transl Med] 2024 Jan 10; Vol. 22 (1), pp. 43. Date of Electronic Publication: 2024 Jan 10.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/genetics
Liver Neoplasms*/genetics
Phosphotransferases (Alcohol Group Acceptor)*
Pyrrolidines*
Sulfones*
Animals ; Humans ; Mice ; Angiogenesis ; Diethylnitrosamine ; Endothelial Cells ; Methanol ; Neovascularization, Pathologic ; Phosphofructokinase-2 ; Sphingosine-1-Phosphate Receptors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Investigating the Mitoprotective Effects of S1P Receptor Modulators Ex Vivo Using a Novel Semi-Automated Live Imaging Set-Up.
Autorzy:
Ludwig R; Experimental and Clinical Research Center (ECRC), 13125 Berlin, Germany.; Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.; Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, 13125 Berlin, Germany.
Malla B; Experimental and Clinical Research Center (ECRC), 13125 Berlin, Germany.; Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.; Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, 13125 Berlin, Germany.
Höhrhan M; Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.; Institute for Medical Immunology, 13353 Berlin, Germany.
Infante-Duarte C; Experimental and Clinical Research Center (ECRC), 13125 Berlin, Germany.; Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.; Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, 13125 Berlin, Germany.
Anderhalten L; Experimental and Clinical Research Center (ECRC), 13125 Berlin, Germany.; Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.; Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, 13125 Berlin, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 23; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 23.
Typ publikacji:
Journal Article
MeSH Terms:
Fingolimod Hydrochloride*/pharmacology
Azetidines*
Animals ; Mice ; Sphingosine-1-Phosphate Receptors ; Benzyl Compounds
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Enhanced Activation of the S1PR2-IL-1β-Src-BDNF-TrkB Pathway Mediates Neuroinflammation in the Hippocampus and Cognitive Impairment in Hyperammonemic Rats.
Autorzy:
Sancho-Alonso M; Laboratory of Neurobiology, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain.; Institute of Biomedical Research of Barcelona (IIBB), Spanish National Research Council (CSIC), 08036 Barcelona, Spain.; Systems Neuropharmacology Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Biomedical Research Networking Center for Mental Health (CIBERSAM), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Arenas YM; Laboratory of Neurobiology, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain.
Izquierdo-Altarejos P; Laboratory of Neurobiology, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain.
Martinez-Garcia M; Laboratory of Neurobiology, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain.
Llansola M; Laboratory of Neurobiology, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain.
Felipo V; Laboratory of Neurobiology, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 08; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 08.
Typ publikacji:
Journal Article
MeSH Terms:
Hyperammonemia*/metabolism
Cognitive Dysfunction*/etiology
Cognitive Dysfunction*/metabolism
Rats ; Animals ; Rats, Wistar ; Brain-Derived Neurotrophic Factor/metabolism ; Neuroinflammatory Diseases ; Sphingosine-1-Phosphate Receptors/metabolism ; Hippocampus/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sphingosine kinase 1/S1P receptor signaling axis is essential for cellular uptake of Neisseria meningitidis in brain endothelial cells.
Autorzy:
Fohmann I; Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Weinmann A; Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Schumacher F; Institute of Pharmacy, Pharmacology and Toxicology, Freie Universität Berlin, Berlin, Germany.
Peters S; Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Prell A; Institute of Pharmacy, Pharmacology and Toxicology, Freie Universität Berlin, Berlin, Germany.
Weigel C; Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.
Spiegel S; Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.
Kleuser B; Institute of Pharmacy, Pharmacology and Toxicology, Freie Universität Berlin, Berlin, Germany.
Schubert-Unkmeir A; Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
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Źródło:
PLoS pathogens [PLoS Pathog] 2023 Nov 30; Vol. 19 (11), pp. e1011842. Date of Electronic Publication: 2023 Nov 30 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Endothelial Cells*/metabolism
Neisseria meningitidis*
Sphingosine-1-Phosphate Receptors/metabolism ; Receptors, Lysosphingolipid/metabolism ; Sphingosine/metabolism ; Brain/metabolism ; Lysophospholipids/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Role of Sphingosine-1-Phosphate Receptor 2 in Mouse Retina Light Responses.
Autorzy:
Shrestha AP; Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Stiles M; Departments of Cell Biology, Neurosurgery, and Pharmacological Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Grambergs RC; Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Boff JM; Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Madireddy S; College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Mondal K; Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Rajmanna R; Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Porter H; Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Sherry DM; Departments of Cell Biology, Neurosurgery, and Pharmacological Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Proia RL; Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Vaithianathan T; Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Mandal N; Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA.; Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
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Źródło:
Biomolecules [Biomolecules] 2023 Nov 23; Vol. 13 (12). Date of Electronic Publication: 2023 Nov 23.
Typ publikacji:
Journal Article
MeSH Terms:
Retina*/metabolism
Electroretinography*
Mice ; Animals ; Sphingosine-1-Phosphate Receptors/metabolism ; Signal Transduction ; Mice, Knockout
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sphingosine-1-Phosphate Receptor 3 Induces Endothelial Barrier Loss via ADAM10-Mediated Vascular Endothelial-Cadherin Cleavage.
Autorzy:
Wu J; Center for Translational Science, Florida International University, Port Saint Lucie, FL 34987, USA.; Department of Environmental Health Sciences, Florida International University, Miami, FL 33199, USA.
Liang Y; Center for Translational Science, Florida International University, Port Saint Lucie, FL 34987, USA.; Department of Environmental Health Sciences, Florida International University, Miami, FL 33199, USA.
Fu P; Center for Translational Science, Florida International University, Port Saint Lucie, FL 34987, USA.; Department of Environmental Health Sciences, Florida International University, Miami, FL 33199, USA.
Feng A; Center for Translational Science, Florida International University, Port Saint Lucie, FL 34987, USA.; Department of Environmental Health Sciences, Florida International University, Miami, FL 33199, USA.
Lu Q; Center for Translational Science, Florida International University, Port Saint Lucie, FL 34987, USA.; Department of Environmental Health Sciences, Florida International University, Miami, FL 33199, USA.
Unwalla HJ; Department of Immunology and Nanomedicine, Florida International University, Miami, FL 33199, USA.
Marciano DP; Center for Translational Science, Florida International University, Port Saint Lucie, FL 34987, USA.; Department of Cellular Biology and Pharmacology, Florida International University, Miami, FL 33199, USA.
Black SM; Center for Translational Science, Florida International University, Port Saint Lucie, FL 34987, USA.; Department of Environmental Health Sciences, Florida International University, Miami, FL 33199, USA.; Department of Cellular Biology and Pharmacology, Florida International University, Miami, FL 33199, USA.
Wang T; Center for Translational Science, Florida International University, Port Saint Lucie, FL 34987, USA.; Department of Environmental Health Sciences, Florida International University, Miami, FL 33199, USA.; Department of Cellular Biology and Pharmacology, Florida International University, Miami, FL 33199, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 08; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 08.
Typ publikacji:
Journal Article
MeSH Terms:
Ventilator-Induced Lung Injury*/metabolism
Pneumonia*
Humans ; Mice ; Animals ; Sphingosine-1-Phosphate Receptors ; Cadherins ; Sphingosine/pharmacology ; Lysophospholipids/pharmacology ; Receptors, Lysosphingolipid/metabolism ; ADAM10 Protein ; Membrane Proteins ; Amyloid Precursor Protein Secretases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood-brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis.
Autorzy:
Zhang Y; Department of Neurosurgery, Neural Injury and Protection Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.; Department of Neurosurgery, Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, China.
Wang L; Department of Neurosurgery, Neural Injury and Protection Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.; Department of Neurosurgery, Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, China.
Pan Q; Department of Neurosurgery, Neural Injury and Protection Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Yang X; Department of Neurosurgery, Neural Injury and Protection Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Cao Y; Department of Neurosurgery, Neural Injury and Protection Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Yan J; Department of Neurosurgery, Neural Injury and Protection Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Wang Y; Department of Neurosurgery, Neural Injury and Protection Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Tao Y; Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Fan R; Department of Neurosurgery, Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, China.
Sun X; Department of Neurosurgery, Neural Injury and Protection Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. .
Li L; Department of Neurosurgery, Neural Injury and Protection Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. .
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Źródło:
Fluids and barriers of the CNS [Fluids Barriers CNS] 2022 Jul 11; Vol. 19 (1), pp. 57. Date of Electronic Publication: 2022 Jul 11.
Typ publikacji:
Journal Article
MeSH Terms:
Blood-Brain Barrier*/metabolism
Blood-Brain Barrier*/pathology
Brain Injuries, Traumatic*/drug therapy
Brain Injuries, Traumatic*/metabolism
Brain Injuries, Traumatic*/pathology
Sphingosine-1-Phosphate Receptors*/metabolism
Stroke*/metabolism
Animals ; Brain Ischemia/metabolism ; Brain Ischemia/pathology ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Mice ; Transcytosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Letter: the sphingosine 1 phosphate/sphingosine 1 phosphate receptor axis-a unique therapeutic target in inflammatory bowel disease. Authors' reply.
Autorzy:
Wang J; Henan Key Laboratory of Immunology and Targeted Drug, Xinxiang Medical University, Xinxiang, China.; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Goren I; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.; Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Rieder F; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.; Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
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Źródło:
Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2022 May; Vol. 55 (10), pp. 1360.
Typ publikacji:
Letter; Comment
MeSH Terms:
Inflammatory Bowel Diseases*/drug therapy
Inflammatory Bowel Diseases*/metabolism
Lysophospholipids*/metabolism
Sphingosine-1-Phosphate Receptors*/metabolism
Sphingosine/*analogs & derivatives
Humans ; Molecular Targeted Therapy ; Signal Transduction/drug effects ; Sphingosine/metabolism
Opinia redakcyjna
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Tytuł:
Letter: the sphingosine 1 phosphate/sphingosine 1 phosphate receptor axis-a unique therapeutic target in inflammatory bowel disease.
Autorzy:
Radeke HH; Interdisziplinäres Crohn-Colitis Centrum Rhein-Main, Frankfurt am Main, Germany.; pharmazentrum frankfurt, Institute of Pharmacology and Toxicology, Hospital of the Goethe University, Frankfurt am Main, Germany.
Stein J; Interdisziplinäres Crohn-Colitis Centrum Rhein-Main, Frankfurt am Main, Germany.; Gastroenterology and Clinical Nutrition, DGD Kliniken Sachsenhausen, Frankfurt am Main, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.
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Źródło:
Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2022 May; Vol. 55 (10), pp. 1359.
Typ publikacji:
Letter; Comment
MeSH Terms:
Inflammatory Bowel Diseases*/drug therapy
Inflammatory Bowel Diseases*/metabolism
Lysophospholipids*/metabolism
Sphingosine-1-Phosphate Receptors*/metabolism
Sphingosine/*analogs & derivatives
Humans ; Molecular Targeted Therapy ; Signal Transduction/drug effects ; Sphingosine/metabolism
Opinia redakcyjna
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Tytuł:
The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells.
Autorzy:
Johansen VBI; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.; Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Hampson E; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.; Vernalis (R&D) Ltd., Cambridge, UK.
Tsonou E; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Pantarelli C; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.
Chu JY; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.
Crossland L; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.
Okkenhaug H; Imaging Facility, The Babraham Institute, Cambridge, UK.
Massey AJ; Vernalis (R&D) Ltd., Cambridge, UK.
Hornigold DC; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Welch HCE; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. .
Chetwynd SA; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. .
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 25; Vol. 13 (1), pp. 18237. Date of Electronic Publication: 2023 Oct 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, G-Protein-Coupled*/genetics
Receptors, G-Protein-Coupled*/metabolism
Signal Transduction*
Animals ; Rats ; Cell Cycle ; PC12 Cells ; Sphingosine-1-Phosphate Receptors ; Cell Survival/genetics
Czasopismo naukowe
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Tytuł:
Clinical Significance of Sphingosine 1-phosphate Receptor 2 and Takeda G Protein-coupled Receptor 5 in Extrahepatic Cholangiocarcinoma Patients.
Autorzy:
Kim H; Department of Pathology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea. . .
Kim HJ; Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea. . .
Park YT; Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea. .
Kim JS; Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea. .
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Źródło:
Journal of gastrointestinal and liver diseases : JGLD [J Gastrointestin Liver Dis] 2023 Sep 29; Vol. 32 (3), pp. 371-376. Date of Electronic Publication: 2023 Sep 29.
Typ publikacji:
Journal Article
MeSH Terms:
Bile Duct Neoplasms*/surgery
Bile Duct Neoplasms*/pathology
Cholangiocarcinoma*/pathology
Humans ; Sphingosine-1-Phosphate Receptors ; Clinical Relevance ; Receptors, G-Protein-Coupled/metabolism ; Bile Ducts, Intrahepatic/pathology
Czasopismo naukowe
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Tytuł:
The Role of Sphingolipids and Sphingosine-1-phosphate-Sphingosine-1-phosphate-receptor Signaling in Psoriasis.
Autorzy:
Masuda-Kuroki K; Department of Dermatology, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Alimohammadi S; Department of Dermatology, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Di Nardo A; Department of Dermatology, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
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Źródło:
Cells [Cells] 2023 Sep 26; Vol. 12 (19). Date of Electronic Publication: 2023 Sep 26.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural
MeSH Terms:
Sphingolipids*/metabolism
Psoriasis*/drug therapy
Humans ; Sphingosine-1-Phosphate Receptors/therapeutic use ; Inflammation/metabolism
Czasopismo naukowe
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Tytuł:
Presynaptic Release-Regulating Sphingosine 1-Phosphate 1/3 Receptors in Cortical Glutamatergic Terminals: Adaptations in EAE Mice and Impact of Therapeutic FTY720.
Autorzy:
Roggeri A; Department of Pharmacy (DiFar), University of Genoa, Viale Cembrano 4, 16148 Genoa, Italy.
Olivero G; Department of Pharmacy (DiFar), University of Genoa, Viale Cembrano 4, 16148 Genoa, Italy.
Usai C; Institute of Biophysics, National Research Council, Via De Marini 6, 16149 Genoa, Italy.
Vanmierlo T; Department of Neuroscience, Biomedical Research Institute, European Graduate School of Neuroscience, Hasselt University, B-3590 Hasselt, Belgium.; Department of Psychiatry and Neuropsychology, School for Mental Health and Neurosciences, Division Translational Neuroscience, Maastricht University, 6200 MD Maastricht, The Netherlands.
Pittaluga A; Department of Pharmacy (DiFar), Center of Excellence for Biomedical Research, 3Rs Center, University of Genoa, Viale Cembrano 4, 16148 Genoa, Italy.; IRCCS Ospedale Policlinico San Martino, 16145 Genoa, Italy.
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Źródło:
Cells [Cells] 2023 Sep 24; Vol. 12 (19). Date of Electronic Publication: 2023 Sep 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Encephalomyelitis, Autoimmune, Experimental*/metabolism
Mice ; Animals ; Fingolimod Hydrochloride/pharmacology ; Fingolimod Hydrochloride/therapeutic use ; Sphingosine-1-Phosphate Receptors/therapeutic use ; Glutamic Acid/metabolism
Czasopismo naukowe
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Tytuł:
S. epidermidis Rescues Allergic Contact Dermatitis in Sphingosine 1-Phosphate Receptor 2-Deficient Skin.
Autorzy:
Masuda-Kuroki K; Department of Dermatology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Alimohammadi S; Department of Dermatology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Di Nardo A; Department of Dermatology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 25; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 25.
Typ publikacji:
Journal Article
MeSH Terms:
Skin*
Dermatitis, Allergic Contact*
Animals ; Mice ; Sphingosine-1-Phosphate Receptors ; Claudin-1 ; Health Status ; Staphylococcus epidermidis
Czasopismo naukowe
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Tytuł:
The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism.
Autorzy:
Pitman MR; Molecular Therapeutics Laboratory, Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, Australia. .; School of Biological Sciences, University of Adelaide, Adelaide, Australia. .
Lewis AC; Molecular Therapeutics Laboratory, Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, Australia.
Davies LT; Molecular Therapeutics Laboratory, Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, Australia.
Moretti PAB; Molecular Therapeutics Laboratory, Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, Australia.
Anderson D; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
Creek DJ; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
Powell JA; Molecular Therapeutics Laboratory, Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, Australia.
Pitson SM; Molecular Therapeutics Laboratory, Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, Australia. .; School of Biological Sciences, University of Adelaide, Adelaide, Australia. .; Adelaide Medical School, University of Adelaide, Adelaide, Australia. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jan 10; Vol. 12 (1), pp. 454. Date of Electronic Publication: 2022 Jan 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Pyrazoles/*chemistry
Pyridines/*chemistry
Sphingolipids/*metabolism
Sphingosine-1-Phosphate Receptors/*antagonists & inhibitors
Sphingosine-1-Phosphate Receptors/*metabolism
HEK293 Cells ; Humans ; Kinetics ; Oxidoreductases/chemistry ; Oxidoreductases/genetics ; Oxidoreductases/metabolism ; Pyrazoles/pharmacology ; Pyridines/pharmacology ; Sphingosine-1-Phosphate Receptors/genetics
Czasopismo naukowe
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Wyświetlanie 1-20 z 362

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