In Vitro and In Vivo Drug-Response Profiling Using Patient-Derived High-Grade Glioma.
Autorzy:
Rajan RG; Helene and Stephen Weicholz Cell Therapy Laboratory, Marcus Neuroscience Institute, Boca Raton Regional Hospital, 800 Meadows Road, Boca Raton, FL 33486, USA. Fernandez-Vega V; The Herbert Wertheim UF Scripps Institute Molecular Screening Center, Department of Molecular Medicine, UF Scripps Biomedical Research, 130 Scripps Way, Jupiter, FL 33458, USA. Sperry J; Certis Oncology, 5626 Oberlin Dr. Suite 110, San Diego, CA 92121, USA. Nakashima J; Certis Oncology, 5626 Oberlin Dr. Suite 110, San Diego, CA 92121, USA. Do LH; Certis Oncology, 5626 Oberlin Dr. Suite 110, San Diego, CA 92121, USA. Andrews W; Certis Oncology, 5626 Oberlin Dr. Suite 110, San Diego, CA 92121, USA. Boca S; Innovation Center for Biomedical Informatics (ICBI), Departments of Oncology and Biostatistics, Bioinformatics and Biomathematics, Georgetown University Medical Center, 2115 Wisconsin Ave NW, Suite G100, Washington, DC 20007, USA. Islam R; Florida Atlantic University College of Medicine, 777 Glades Road, Boca Raton, FL 33431, USA. Chowdhary SA; Helene and Stephen Weicholz Cell Therapy Laboratory, Marcus Neuroscience Institute, Boca Raton Regional Hospital, 800 Meadows Road, Boca Raton, FL 33486, USA. Seldin J; Greiner Bio-One North America, Inc., 4238 Capital Drive, Monroe, NC 28110, USA. Souza GR; Greiner Bio-One North America, Inc., 4238 Capital Drive, Monroe, NC 28110, USA. Scampavia L; The Herbert Wertheim UF Scripps Institute Molecular Screening Center, Department of Molecular Medicine, UF Scripps Biomedical Research, 130 Scripps Way, Jupiter, FL 33458, USA. Hanafy KA; Helene and Stephen Weicholz Cell Therapy Laboratory, Marcus Neuroscience Institute, Boca Raton Regional Hospital, 800 Meadows Road, Boca Raton, FL 33486, USA.; Florida Atlantic University College of Medicine, 777 Glades Road, Boca Raton, FL 33431, USA. Vrionis FD; Helene and Stephen Weicholz Cell Therapy Laboratory, Marcus Neuroscience Institute, Boca Raton Regional Hospital, 800 Meadows Road, Boca Raton, FL 33486, USA.; Florida Atlantic University College of Medicine, 777 Glades Road, Boca Raton, FL 33431, USA. SpicerTP; The Herbert Wertheim UF Scripps Institute Molecular Screening Center, Department of Molecular Medicine, UF Scripps Biomedical Research, 130 Scripps Way, Jupiter, FL 33458, USA.
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Źródło:
Cancers [Cancers (Basel)] 2023 Jun 22; Vol. 15 (13). Date of Electronic Publication: 2023 Jun 22.
Identification of novel modulators of a schistosome transient receptor potential channel targeted by praziquantel.
Autorzy:
Chulkov EG; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America. Smith E; Department of Molecular Medicine, Scripps Research, Jupiter, Florida, United States of America. Rohr CM; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America. Yahya NA; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.; Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America. Park SK; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America. Scampavia L; Department of Molecular Medicine, Scripps Research, Jupiter, Florida, United States of America. SpicerTP; Department of Molecular Medicine, Scripps Research, Jupiter, Florida, United States of America. Marchant JS; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Nov 03; Vol. 15 (11), pp. e0009898. Date of Electronic Publication: 2021 Nov 03 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Discovery and Optimization of Selective Inhibitors of Meprin α (Part I).
Autorzy:
Hou S; Department of Molecular Medicine, The Scripps Research Molecular Screening Center, Scripps Research, Jupiter, FL 33458, USA. Diez J; Rumbaugh-Goodwin Institute for Cancer Research, Nova Southeastern University, 3321 College Avenue, CCR r.605, Fort Lauderdale, FL 33314, USA. Wang C; Department of Molecular Medicine, The Scripps Research Molecular Screening Center, Scripps Research, Jupiter, FL 33458, USA. Becker-Pauly C; Unit for Degradomics of the Protease Web, Institute of Biochemistry, University of Kiel, Rudolf-Höber-Str.1, 24118 Kiel, Germany. Fields GB; Department of Chemistry & Biochemistry and I-HEALTH, Florida Atlantic University, 5353 Parkside Drive, Jupiter, FL 33458, USA. Bannister T; Department of Molecular Medicine, The Scripps Research Molecular Screening Center, Scripps Research, Jupiter, FL 33458, USA. SpicerTP; Department of Molecular Medicine, The Scripps Research Molecular Screening Center, Scripps Research, Jupiter, FL 33458, USA. Scampavia LD; Department of Molecular Medicine, The Scripps Research Molecular Screening Center, Scripps Research, Jupiter, FL 33458, USA. Minond D; Rumbaugh-Goodwin Institute for Cancer Research, Nova Southeastern University, 3321 College Avenue, CCR r.605, Fort Lauderdale, FL 33314, USA.; Dr. Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University, 3301 College Avenue, Fort Lauderdale, FL 33314, USA.
Discovery and Optimization of Selective Inhibitors of Meprin α (Part II).
Autorzy:
Wang C; Department of Molecular Medicine, Scripps Research, Jupiter, FL 33458, USA.; Department of Chemistry, Scripps Research, Jupiter, FL 33458, USA. Diez J; Rumbaugh-Goodwin Institute for Cancer Research, Nova Southeastern University, 3321 College Avenue, CCR r.605, Fort Lauderdale, FL 33314, USA. Park H; Department of Molecular Medicine, Scripps Research, Jupiter, FL 33458, USA. SpicerTP; Department of Molecular Medicine, Scripps Research, Jupiter, FL 33458, USA.; The Scripps Research Molecular Screening Center, Scripps Research, Jupiter, FL 33458, USA. Scampavia LD; Department of Molecular Medicine, Scripps Research, Jupiter, FL 33458, USA.; The Scripps Research Molecular Screening Center, Scripps Research, Jupiter, FL 33458, USA. Becker-Pauly C; Unit for Degradomics of the Protease Web, University of Kiel, Institute of Biochemistry, Rudolf-Höber-Str.1, 24118 Kiel, Germany. Fields GB; Department of Chemistry & Biochemistry and I-HEALTH, Florida Atlantic University, 5353 Parkside Drive, Jupiter, FL 33458, USA. Minond D; Department of Chemistry, Scripps Research, Jupiter, FL 33458, USA.; Dr. Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University, 3301 College Avenue, Fort Lauderdale, FL 33314, USA. Bannister TD; Department of Molecular Medicine, Scripps Research, Jupiter, FL 33458, USA.; Department of Chemistry, Scripps Research, Jupiter, FL 33458, USA.
Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity.
Autorzy:
Smith E; Department of Molecular Medicine, The Scripps Research Molecular Screening Center, Scripps Research Florida, 130 Scripps Way #1A1, Jupiter, FL, 33458, USA. Janovick JA; Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX, USA. Bannister TD; Department of Chemistry, The Scripps Research Molecular Screening Center, Scripps Research Florida, 130 Scripps Way, Jupiter, FL, USA. Shumate J; Department of Molecular Medicine, The Scripps Research Molecular Screening Center, Scripps Research Florida, 130 Scripps Way #1A1, Jupiter, FL, 33458, USA. Ganapathy V; Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX, USA. Scampavia L; Department of Molecular Medicine, The Scripps Research Molecular Screening Center, Scripps Research Florida, 130 Scripps Way #1A1, Jupiter, FL, 33458, USA. SpicerTP; Department of Molecular Medicine, The Scripps Research Molecular Screening Center, Scripps Research Florida, 130 Scripps Way #1A1, Jupiter, FL, 33458, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Jun 29; Vol. 10 (1), pp. 10579. Date of Electronic Publication: 2020 Jun 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons.
Autorzy:
Sridharan B; The Scripps Research Molecular Screening Center, Department of Molecular Medicine, Scripps Research, Jupiter, Florida, 33458, USA. Hubbs C; Department of Neuroscience, Scripps Research, Jupiter, Florida, 33458, USA. Llamosas N; Department of Neuroscience, Scripps Research, Jupiter, Florida, 33458, USA. Kilinc M; Graduate School of Chemical and Biological Sciences, Scripps Research, Jupiter, Florida, 33458, USA. Singhera FU; The Scripps Research Molecular Screening Center, Department of Molecular Medicine, Scripps Research, Jupiter, Florida, 33458, USA. Willems E; Cell Biology, Thermo Fisher Scientific, Carlsbad, California, 92008, USA. Piper DR; Cell Biology, Thermo Fisher Scientific, Carlsbad, California, 92008, USA. Scampavia L; The Scripps Research Molecular Screening Center, Department of Molecular Medicine, Scripps Research, Jupiter, Florida, 33458, USA. Rumbaugh G; The Scripps Research Molecular Screening Center, Department of Molecular Medicine, Scripps Research, Jupiter, Florida, 33458, USA. .; Department of Neuroscience, Scripps Research, Jupiter, Florida, 33458, USA. .; Graduate School of Chemical and Biological Sciences, Scripps Research, Jupiter, Florida, 33458, USA. . SpicerTP; The Scripps Research Molecular Screening Center, Department of Molecular Medicine, Scripps Research, Jupiter, Florida, 33458, USA. .
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Źródło:
Scientific reports [Sci Rep] 2019 Jun 21; Vol. 9 (1), pp. 9000. Date of Electronic Publication: 2019 Jun 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias.
Autorzy:
Janovick JA; Departments of Internal Medicine and Cell Biology/Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America. SpicerTP; Lead Identification Division, Translational Research Institute and Department of Molecular Therapeutics, Scripps Research Institute, Jupiter, Florida, United States of America. Bannister TD; Department of Chemistry, Scripps Research Institute, Jupiter, Florida, United States of America. Scampavia L; Lead Identification Division, Translational Research Institute and Department of Molecular Therapeutics, Scripps Research Institute, Jupiter, Florida, United States of America. Conn PM; Departments of Internal Medicine and Cell Biology/Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America.
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Źródło:
PloS one [PLoS One] 2017 Aug 02; Vol. 12 (8), pp. e0181830. Date of Electronic Publication: 2017 Aug 02 (Print Publication: 2017).
Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1.
Autorzy:
Ting PY; Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America. Damoiseaux R; California NanoSystems Institute, University of California Los Angeles, Los Angeles, California, United States of America. Titz B; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, University of California at Los Angeles Metabolomics and Proteomics Center, California NanoSystems Institute and Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, United States of America. Bradley KA; Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, and California NanoSystems Institute, University of California Los Angeles, Los Angeles, California, United States of America. Graeber TG; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, University of California at Los Angeles Metabolomics and Proteomics Center, California NanoSystems Institute and Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, United States of America. Fernández-Vega V; The Scripps Research Institute-FL, Lead Identification, Translational Research Institute, Jupiter, Florida, United States of America. Bannister TD; The Scripps Research Institute-FL, Department of Chemistry, Translational Research Institute, Jupiter, Florida, United States of America. Chase P; The Scripps Research Institute-FL, Lead Identification, Translational Research Institute, Jupiter, Florida, United States of America. Nair R; The Scripps Research Institute-FL, Department of Chemistry, Translational Research Institute, Jupiter, Florida, United States of America. Scampavia L; The Scripps Research Institute-FL, Lead Identification, Translational Research Institute, Jupiter, Florida, United States of America. Hodder P; The Scripps Research Institute-FL, Lead Identification, Translational Research Institute, Jupiter, Florida, United States of America. SpicerTP; The Scripps Research Institute-FL, Lead Identification, Translational Research Institute, Jupiter, Florida, United States of America. Colicelli J; Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America.
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Źródło:
PloS one [PLoS One] 2015 Mar 26; Vol. 10 (3), pp. e0121833. Date of Electronic Publication: 2015 Mar 26 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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