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Wyszukujesz frazę ""Spike Glycoprotein, Coronavirus"" wg kryterium: Temat


Tytuł:
Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2.
Autorzy:
Huang KA; Graduate Institute of Immunology and Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. .; Genomics Research Center, Academia Sinica, Taipei, Taiwan. .; College of Medicine, Chang Gung University, Taoyuan, Taiwan. .
Chen X; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Mohapatra A; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Nguyen HTV; Genomics Research Center, Academia Sinica, Taipei, Taiwan.; Chemical Biology and Molecular Biophysics program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan.; Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan.
Schimanski L; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Tan TK; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Rijal P; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Vester SK; Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK.
Hills RA; Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK.
Howarth M; Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK.; Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK.
Keeffe JR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, USA.
Cohen AA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, USA.
Kakutani LM; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, USA.
Wu YM; Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan.
Shahed-Al-Mahmud M; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Chou YC; Biomedical Translation Research Center, Academia Sinica, Taipei, 11529, Taiwan.
Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, USA.
Townsend AR; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Ma C; Genomics Research Center, Academia Sinica, Taipei, Taiwan. .
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Źródło:
Nature communications [Nat Commun] 2023 Jan 19; Vol. 14 (1), pp. 311. Date of Electronic Publication: 2023 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Antibodies, Neutralizing*
Antibodies, Viral*
COVID-19*
Spike Glycoprotein, Coronavirus*/genetics
Spike Glycoprotein, Coronavirus*/immunology
Humans ; Epitopes ; SARS-CoV-2 ; Severe acute respiratory syndrome-related coronavirus
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
A fast, efficient, and scalable method for purifying recombinant SARS-CoV-2 spike protein.
Autorzy:
Butani N; Department of Chemical Engineering, McMaster University, Hamilton, ON L8S 4L7, Canada.
Xu Y; Department of Chemical Engineering, McMaster University, Hamilton, ON L8S 4L7, Canada.
Pan S; Department of Chemical Engineering, McMaster University, Hamilton, ON L8S 4L7, Canada.
Durocher Y; National Research Council of Canada, Montreal, QC H4P 2R2, Canada; Département de biochimie et médecine moléculaire, Faculté de médecine, Université de Montréal, Montreal, QC H3C 3J7, Canada.
Ghosh R; Department of Chemical Engineering, McMaster University, Hamilton, ON L8S 4L7, Canada. Electronic address: .
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Źródło:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2023 Jan 15; Vol. 1215, pp. 123579. Date of Electronic Publication: 2022 Dec 20.
Typ publikacji:
Journal Article
MeSH Terms:
Spike Glycoprotein, Coronavirus*/biosynthesis
Spike Glycoprotein, Coronavirus*/isolation & purification
Recombinant Proteins*/biosynthesis
Recombinant Proteins*/isolation & purification
COVID-19 Vaccines ; SARS-CoV-2/genetics
Czasopismo naukowe
Tytuł:
Proline-Proline Dyad in the Fusion Peptide of the Murine β-Coronavirus Spike Protein's S2 Domain Modulates Its Neuroglial Tropism.
Autorzy:
Safiriyu AA; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, India.
Mulchandani V; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, India.
Anakkacheri MN; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, India.
Pal D; Department of Computational and Data Sciences, Indian Institute of Science, Bengaluru 560012, India.
Das Sarma J; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, India.
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Źródło:
Viruses [Viruses] 2023 Jan 12; Vol. 15 (1). Date of Electronic Publication: 2023 Jan 12.
Typ publikacji:
Journal Article
MeSH Terms:
Murine hepatitis virus*/physiology
Spike Glycoprotein, Coronavirus*/genetics
Spike Glycoprotein, Coronavirus*/metabolism
Viral Tropism*
Animals ; Mice ; Peptides/metabolism ; Proline ; Viral Envelope Proteins/metabolism
Czasopismo naukowe
Tytuł:
Liquid biomarkers of macrophage dysregulation and circulating spike protein illustrate the biological heterogeneity in patients with post-acute sequelae of COVID-19.
Autorzy:
Schultheiß C; Department of Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Willscher E; Department of Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Paschold L; Department of Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Gottschick C; Institute for Medical Epidemiology, Biometrics and Informatics (IMEBI), Interdisciplinary Center for Health Sciences, Medical School of the Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany.
Klee B; Institute for Medical Epidemiology, Biometrics and Informatics (IMEBI), Interdisciplinary Center for Health Sciences, Medical School of the Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany.
Bosurgi L; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Protozoa Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Dutzmann J;  Department of Cardiology and Intensive Care Medicine, Mid-German Heart Center, University Hospital, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Sedding D;  Department of Cardiology and Intensive Care Medicine, Mid-German Heart Center, University Hospital, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Frese T; Institute of General Practice and Family Medicine, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Girndt M; Department of Internal Medicine II, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Höll JI; Pediatric Hematology and Oncology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Gekle M; Julius Bernstein-Institute of Physiology, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Mikolajczyk R; Institute for Medical Epidemiology, Biometrics and Informatics (IMEBI), Interdisciplinary Center for Health Sciences, Medical School of the Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany.
Binder M; Department of Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
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Źródło:
Journal of medical virology [J Med Virol] 2023 Jan; Vol. 95 (1), pp. e28364.
Typ publikacji:
Journal Article
MeSH Terms:
Post-Acute COVID-19 Syndrome*/diagnosis
Post-Acute COVID-19 Syndrome*/metabolism
Spike Glycoprotein, Coronavirus*/blood
Spike Glycoprotein, Coronavirus*/chemistry
Humans ; Biomarkers ; Cohort Studies ; COVID-19/complications ; Disease Progression ; Quality of Life ; SARS-CoV-2 ; Macrophages/metabolism
Czasopismo naukowe
Tytuł:
SARS-CoV-2 Spike Protein Mutation at Cysteine-488 Impairs Its Golgi Localization and Intracellular S1/S2 Processing.
Autorzy:
Yamamoto Y; Laboratory of Molecular Targeted Therapy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.
Inoue T; Laboratory of Molecular Targeted Therapy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.
Inoue M; Laboratory of Molecular Targeted Therapy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.
Murae M; Laboratory of Molecular Targeted Therapy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Fukasawa M; Laboratory of Molecular Targeted Therapy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Kaneko MK; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Sendai 980-8575, Miyagi, Japan.
Kato Y; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Sendai 980-8575, Miyagi, Japan.; Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Sendai 980-8575, Miyagi, Japan.
Noguchi K; Laboratory of Molecular Targeted Therapy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 13; Vol. 23 (24). Date of Electronic Publication: 2022 Dec 13.
Typ publikacji:
Journal Article
MeSH Terms:
Spike Glycoprotein, Coronavirus*/genetics
Spike Glycoprotein, Coronavirus*/metabolism
Golgi Apparatus*
Humans ; Angiotensin-Converting Enzyme 2/genetics ; COVID-19/virology ; Cysteine/genetics ; Mutation ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; Virus Internalization
Czasopismo naukowe
Tytuł:
From the Wuhan-Hu-1 strain to the XD and XE variants: is targeting the SARS-CoV-2 spike protein still a pharmaceutically relevant option against COVID-19?
Autorzy:
Pavan M; Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
Bassani D; Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
Sturlese M; Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
Moro S; Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 1704-1714.
Typ publikacji:
Journal Article
MeSH Terms:
Spike Glycoprotein, Coronavirus*/genetics
Spike Glycoprotein, Coronavirus*/metabolism
COVID-19 Drug Treatment*
Humans ; Mutation ; Pandemics/prevention & control ; SARS-CoV-2
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Host-cell recognition of SARS-CoV-2 spike receptor binding domain from different variants.
Autorzy:
Elfiky AA; Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt. Electronic address: dr_.
Ibrahim IM; Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt.
Ibrahim MN; Clinical Laboratories Department, College of Applied Medical Sciences, Jouf University, Sakakah, Saudi Arabia.
Elshemey WM; Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt; Department of Physics, Faculty of Science, Islamic University of Madinah, Madinah 42351, Saudi Arabia.
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Źródło:
The Journal of infection [J Infect] 2022 Dec; Vol. 85 (6), pp. 702-769. Date of Electronic Publication: 2022 Oct 09.
Typ publikacji:
Letter
MeSH Terms:
COVID-19*
SARS-CoV-2*/genetics
Spike Glycoprotein, Coronavirus*/chemistry
Spike Glycoprotein, Coronavirus*/metabolism
Humans ; Mutation ; Protein Binding
Opinia redakcyjna
Tytuł:
Rapid quantitative monitoring of SARS-CoV-2 spike protein-mediated syncytia formation using split NanoLuc.
Autorzy:
Wang H; Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Guo S; Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Yang H; Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
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Źródło:
Journal of medical virology [J Med Virol] 2022 Dec; Vol. 94 (12), pp. 6073-6077. Date of Electronic Publication: 2022 Aug 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19*
Spike Glycoprotein, Coronavirus*/genetics
Spike Glycoprotein, Coronavirus*/metabolism
Angiotensin-Converting Enzyme 2 ; Furin/metabolism ; Humans ; Luciferases ; Peptidyl-Dipeptidase A/metabolism ; SARS-CoV-2/genetics ; Virus Internalization
Czasopismo naukowe
Tytuł:
Computer simulations on oxidative stress-induced reactions in SARS-CoV-2 spike glycoprotein: a multi-scale approach.
Autorzy:
Bertran O; Departament de Física EETAC, Universitat Politècnica de Catalunya, c/Esteve Terrades, 7, 08860, Castelldefels, Spain. .
Martí D; Departament d'Enginyeria Química (DEQ) and Barcelona Research Center in Multiscale Science and Engineering, EEBE, Universitat Politècnica de Catalunya (UPC), C/Eduard Maristany 10-14, 08019, Barcelona, Spain.
Torras J; Departament d'Enginyeria Química (DEQ) and Barcelona Research Center in Multiscale Science and Engineering, EEBE, Universitat Politècnica de Catalunya (UPC), C/Eduard Maristany 10-14, 08019, Barcelona, Spain. .
Turon P; B. Braun Surgical, S.A.U. Carretera de Terrasa 121, 08191, Rubí, Barcelona, Spain. .
Alemán C; Departament d'Enginyeria Química (DEQ) and Barcelona Research Center in Multiscale Science and Engineering, EEBE, Universitat Politècnica de Catalunya (UPC), C/Eduard Maristany 10-14, 08019, Barcelona, Spain. .; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Baldiri Reixac 10-12, 08028, Barcelona, Spain. .
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Źródło:
Molecular diversity [Mol Divers] 2022 Dec; Vol. 26 (6), pp. 3143-3155. Date of Electronic Publication: 2022 Feb 18.
Typ publikacji:
Journal Article
MeSH Terms:
Spike Glycoprotein, Coronavirus*/chemistry
Spike Glycoprotein, Coronavirus*/metabolism
COVID-19*
Humans ; SARS-CoV-2 ; Angiotensin-Converting Enzyme 2 ; Binding Sites ; Molecular Dynamics Simulation ; Protein Binding ; Oxidative Stress
Czasopismo naukowe
Tytuł:
Safety, mucosal and systemic immunopotency of an aerosolized adenovirus-vectored vaccine against SARS-CoV-2 in rhesus macaques.
Autorzy:
Xu F; CanSino Biologics, Tianjin, People's Republic of China.
Wu S; Institute of Biotechnology, Academy of Military Medical Sciences, Beijing, People's Republic of China.
Yi L; CanSino Biologics, Tianjin, People's Republic of China.
Peng S; CanSino Biologics, Tianjin, People's Republic of China.
Wang F; CanSino Biologics, Tianjin, People's Republic of China.
Si W; CanSino Biologics, Tianjin, People's Republic of China.
Hou L; Institute of Biotechnology, Academy of Military Medical Sciences, Beijing, People's Republic of China.
Zhu T; CanSino Biologics, Tianjin, People's Republic of China.
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Źródło:
Emerging microbes & infections [Emerg Microbes Infect] 2022 Dec; Vol. 11 (1), pp. 438-441.
Typ publikacji:
Letter
MeSH Terms:
Immunity, Mucosal*
Adenoviridae/*immunology
COVID-19/*immunology
COVID-19 Vaccines/*immunology
Genetic Vectors/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Adenoviridae/genetics ; Administration, Inhalation ; Animals ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/genetics ; Disease Models, Animal ; Genetic Vectors/genetics ; Humans ; Immunogenicity, Vaccine ; Macaca mulatta ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/administration & dosage ; Spike Glycoprotein, Coronavirus/genetics
Opinia redakcyjna
Tytuł:
Structural heterogeneity and precision of implications drawn from cryo-electron microscopy structures: SARS-CoV-2 spike-protein mutations as a test case.
Autorzy:
Mehra R; Department of Chemistry, Indian Institute of Technology Bhilai, Raipur, Sejbahar, Chhattisgarh, 492015, India. .
Kepp KP; DTU Chemistry, Technical University of Denmark, Building 206, 2800, Kongens Lyngby, Denmark. .
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Źródło:
European biophysics journal : EBJ [Eur Biophys J] 2022 Dec; Vol. 51 (7-8), pp. 555-568. Date of Electronic Publication: 2022 Sep 27.
Typ publikacji:
Journal Article
MeSH Terms:
Spike Glycoprotein, Coronavirus*/genetics
Spike Glycoprotein, Coronavirus*/chemistry
Spike Glycoprotein, Coronavirus*/metabolism
COVID-19*
Humans ; Cryoelectron Microscopy ; SARS-CoV-2/genetics ; Models, Molecular ; Mutation ; Proteins/genetics
Czasopismo naukowe
Tytuł:
Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein.
Autorzy:
Xu S; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
Wang Y; State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
Wang Y; State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
Zhang C; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
Hong Q; State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
Gu C; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Xu R; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
Wang T; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
Yang Y; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
Zang J; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
Zhou Y; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
Li Z; State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
Liu Q; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
Zhou B; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
Bai L; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
Zhu Y; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.; BSL-3 Laboratory of Fudan University, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Deng Q; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Wang H; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
Lavillette D; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
Wong G; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
Xie Y; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.; BSL-3 Laboratory of Fudan University, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Cong Y; State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
Huang Z; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
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Źródło:
Emerging microbes & infections [Emerg Microbes Infect] 2022 Dec; Vol. 11 (1), pp. 351-367.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19/*virology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*chemistry
Spike Glycoprotein, Coronavirus/*immunology
Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/immunology ; Epitope Mapping ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Neutralization Tests ; SARS-CoV-2/chemistry ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics
Czasopismo naukowe
Tytuł:
Furin cleavage is required for swine acute diarrhea syndrome coronavirus spike protein-mediated cell - cell fusion.
Autorzy:
Kim J; Laboratory of Veterinary Public Health, College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.
Yoon J; Laboratory of Veterinary Public Health, College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.
Park JE; Laboratory of Veterinary Public Health, College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.; Research Institute of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.
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Źródło:
Emerging microbes & infections [Emerg Microbes Infect] 2022 Dec; Vol. 11 (1), pp. 2176-2183.
Typ publikacji:
Journal Article
MeSH Terms:
Furin*/metabolism
Spike Glycoprotein, Coronavirus*/genetics
Spike Glycoprotein, Coronavirus*/metabolism
Alphacoronavirus ; Animals ; Antiviral Agents ; Cell Fusion ; Proprotein Convertases ; Swine ; Virus Internalization
SCR Organism:
Swine acute diarrhea syndrome coronavirus
Czasopismo naukowe
Tytuł:
Omicron: a drug developer's perspective.
Autorzy:
Fang FF; Abimmune Biopharma, Inc., San Diego, CA, USA.
Shi PY; Department of Biochemistry and Molecular Biology, Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX, USA.
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Źródło:
Emerging microbes & infections [Emerg Microbes Infect] 2022 Dec; Vol. 11 (1), pp. 208-211.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19 Drug Treatment*
Angiotensin-Converting Enzyme 2/*metabolism
Drug Design/*methods
Receptors, Virus/*metabolism
SARS-CoV-2/*genetics
Spike Glycoprotein, Coronavirus/*genetics
Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/immunology ; Antiviral Agents/chemical synthesis ; Antiviral Agents/therapeutic use ; Binding Sites ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/adverse effects ; Humans ; Immune Evasion ; Mutation ; Protein Binding ; Receptors, Virus/genetics ; Receptors, Virus/immunology ; SARS-CoV-2/drug effects ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/metabolism
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Atomistic insights into the binding of SARS-CoV-2 spike receptor binding domain with the human ACE2 receptor: The importance of residue 493.
Autorzy:
Carter C; Department of Chemistry, Gottwald Center for the Sciences, University of Richmond, Richmond, VA, 23173, USA.
Airas J; Department of Chemistry, Gottwald Center for the Sciences, University of Richmond, Richmond, VA, 23173, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Parish CA; Department of Chemistry, Gottwald Center for the Sciences, University of Richmond, Richmond, VA, 23173, USA. Electronic address: .
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Źródło:
Journal of molecular graphics & modelling [J Mol Graph Model] 2023 Jan; Vol. 118, pp. 108360. Date of Electronic Publication: 2022 Oct 22.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19*
Spike Glycoprotein, Coronavirus*/genetics
Humans ; Angiotensin-Converting Enzyme 2 ; SARS-CoV-2/genetics
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Towards an optimal monoclonal antibody with higher binding affinity to the receptor-binding domain of SARS-CoV-2 spike proteins from different variants.
Autorzy:
Neamtu A; Department of Physiology, 'Grigore T. Popa' University of Medicine and Pharmacy of Iasi, Str. Universitatii nr. 16, 700051 Iasi, România; TRANSCEND Centre - Regional Institute of Oncology (IRO) Iasi, Str. General Henri Mathias Berthelot, Nr. 2-4 Iași, România.
Mocci F; University of Cagliari, Department of Chemical and Geological Sciences, Campus Monserrato, SS 554 bivio per Sestu, 09042 Monserrato, Italy.
Laaksonen A; Centre of Advanced Research in Bionanoconjugates and Biopolymers, PetruPoni Institute of Macromolecular Chemistry Aleea Grigore Ghica-Voda, 41 A, 700487 Iasi, Romania; University of Cagliari, Department of Chemical and Geological Sciences, Campus Monserrato, SS 554 bivio per Sestu, 09042 Monserrato, Italy; Department of Materials and Environmental Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden; State Key Laboratory of Materials-Oriented and Chemical Engineering, Nanjing Tech University, Nanjing 210009, PR China; Department of Engineering Sciences and Mathematics, Division of Energy Science, Luleå University of Technology, SE-97187 Luleå, Sweden.
Barroso da Silva FL; Universidade de São Paulo, Departamento de Ciências Biomoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Av. café, s/no - campus da USP, BR-14040-903 Ribeirão Preto, SP, Brazil; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA. Electronic address: .
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Źródło:
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2023 Jan; Vol. 221, pp. 112986. Date of Electronic Publication: 2022 Oct 29.
Typ publikacji:
Journal Article
MeSH Terms:
Spike Glycoprotein, Coronavirus*/genetics
COVID-19*
Humans ; SARS-CoV-2 ; Antibodies, Monoclonal ; Edible Grain
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model.
Autorzy:
Jiang S; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College (SHMC), Fudan University, Shanghai, China.; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Wu S; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College (SHMC), Fudan University, Shanghai, China.
Zhao G; Biomedical Research Institute of Advaccine (BRIA), Advaccine Biopharmaceutics (Suzhou) Co. LTD, Suzhou City, Jiangsu.
He Y; Biomedical Research Institute of Advaccine (BRIA), Advaccine Biopharmaceutics (Suzhou) Co. LTD, Suzhou City, Jiangsu.
Bao L; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College (PUMC), Beijing, China.
Liu J; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College (PUMC), Beijing, China.
Qin C; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College (PUMC), Beijing, China.
Hou J; Biomedical Research Institute of Advaccine (BRIA), Advaccine Biopharmaceutics (Suzhou) Co. LTD, Suzhou City, Jiangsu.
Ding Y; Biomedical Research Institute of Advaccine (BRIA), Advaccine Biopharmaceutics (Suzhou) Co. LTD, Suzhou City, Jiangsu.
Cheng A; Biomedical Research Institute of Advaccine (BRIA), Advaccine Biopharmaceutics (Suzhou) Co. LTD, Suzhou City, Jiangsu.
Jiang B; Biomedical Research Institute of Advaccine (BRIA), Advaccine Biopharmaceutics (Suzhou) Co. LTD, Suzhou City, Jiangsu.
Wu J; Biomedical Research Institute of Advaccine (BRIA), Advaccine Biopharmaceutics (Suzhou) Co. LTD, Suzhou City, Jiangsu.
Yan J; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
Humeau L; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
Patella A; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
Weiner DB; The Wistar Institute, Philadelphia, PA, USA.
Broderick K; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
Wang B; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College (SHMC), Fudan University, Shanghai, China.; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
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Źródło:
Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2022 Dec 31; Vol. 18 (1), pp. 2016201. Date of Electronic Publication: 2022 Jan 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19*/prevention & control
Spike Glycoprotein, Coronavirus*/genetics
Animals ; Antibodies, Neutralizing ; Antibodies, Viral ; Base Sequence ; Mice ; SARS-CoV-2/genetics
Czasopismo naukowe
Tytuł:
The Elusive Coreceptors for the SARS-CoV-2 Spike Protein.
Autorzy:
Berkowitz RL; Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Ostrov DA; Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA.
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Źródło:
Viruses [Viruses] 2022 Dec 25; Vol. 15 (1). Date of Electronic Publication: 2022 Dec 25.
Typ publikacji:
Journal Article; Review
MeSH Terms:
COVID-19*
Spike Glycoprotein, Coronavirus*/genetics
Receptors, Virus*/metabolism
Humans ; Antiviral Agents/pharmacology ; Membrane Proteins ; Protein Binding ; SARS-CoV-2/genetics
Czasopismo naukowe
Tytuł:
Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level.
Autorzy:
Zhu R; Department of Experimental Applied Biophysics, Johannes Kepler University Linz, Linz, Austria.
Canena D; Department of Experimental Applied Biophysics, Johannes Kepler University Linz, Linz, Austria.
Sikora M; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.; Faculty of Physics, University of Vienna, Vienna, Austria.; Malopolska Centre of Biotechnology, Gronostajowa 7A, 30-387, Kraków, Poland.
Klausberger M; Department of Biotechnology, Institute of Molecular Biotechnology, University of Natural Resources and Life Sciences, Vienna, Vienna, Austria.
Seferovic H; Department of Experimental Applied Biophysics, Johannes Kepler University Linz, Linz, Austria.
Mehdipour AR; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.; Center for Molecular Modeling, University of Ghent, Ghent, Belgium.
Hain L; Department of Experimental Applied Biophysics, Johannes Kepler University Linz, Linz, Austria.
Laurent E; Department of Biotechnology, Institute of Molecular Biotechnology, University of Natural Resources and Life Sciences, Vienna, Vienna, Austria.; Core Facility Biomolecular & Cellular Analysis, University of Natural Resources and Life Sciences, Vienna, Vienna, Austria.
Monteil V; Department of Laboratory Medicine, Unit of Clinical Microbiology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
Wirnsberger G; Apeiron Biologics, Vienna, Austria.
Wieneke R; Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt, Germany.
Tampé R; Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt, Germany.
Kienzl NF; Department of Applied Genetics and Cell Biology, Institute of Plant Biotechnology and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Vienna, Austria.
Mach L; Department of Applied Genetics and Cell Biology, Institute of Plant Biotechnology and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Vienna, Austria.
Mirazimi A; Department of Laboratory Medicine, Unit of Clinical Microbiology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.; National Veterinary Institute, Uppsala, Sweden.
Oh YJ; Department of Experimental Applied Biophysics, Johannes Kepler University Linz, Linz, Austria.
Penninger JM; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna, Austria. .; Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada. .
Hummer G; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany. .; Institute of Biophysics, Goethe University Frankfurt, Frankfurt am Main, Germany. .
Hinterdorfer P; Department of Experimental Applied Biophysics, Johannes Kepler University Linz, Linz, Austria. .
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Źródło:
Nature communications [Nat Commun] 2022 Dec 24; Vol. 13 (1), pp. 7926. Date of Electronic Publication: 2022 Dec 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Angiotensin-Converting Enzyme 2*/metabolism
COVID-19*/virology
SARS-CoV-2*/metabolism
SARS-CoV-2*/physiology
Spike Glycoprotein, Coronavirus*/metabolism
Single Molecule Imaging*
Humans ; Virus Attachment
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Direct Inhibition of SARS-CoV-2 Spike Protein by Peracetic Acid.
Autorzy:
Yamamoto Y; Laboratory of Molecular Targeted Therapy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.
Nakano Y; Department of Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.
Murae M; Laboratory of Molecular Targeted Therapy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Shimizu Y; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.; Department of Pharmaceutical Sciences, Teikyo Heisei University, 4-21-2, Nakano, Nakano-ku, Tokyo 164-8530, Japan.
Sakai S; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Ogawa M; Department of Virology I, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Mizukami T; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Inoue T; Laboratory of Molecular Targeted Therapy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.
Onodera T; Reseach Center for Drug and Vaccine Development, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Takahashi Y; Reseach Center for Drug and Vaccine Development, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Wakita T; Department of Virology II, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Fukasawa M; Laboratory of Molecular Targeted Therapy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Miyazaki S; Department of Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.
Noguchi K; Laboratory of Molecular Targeted Therapy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 20; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 20.
Typ publikacji:
Journal Article
MeSH Terms:
Spike Glycoprotein, Coronavirus*
COVID-19*
Humans ; Peracetic Acid/pharmacology ; Angiotensin-Converting Enzyme 2 ; SARS-CoV-2 ; Protein Binding
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe

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