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Wyszukujesz frazę ""Spike Glycoprotein, Coronavirus"" wg kryterium: Temat


Tytuł :
Prospective mapping of viral mutations that escape antibodies used to treat COVID-19.
Autorzy :
Starr TN; Basic Sciences and Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Greaney AJ; Basic Sciences and Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Department of Genome Sciences, University of Washington, Seattle, WA 98109, USA.; Medical Scientist Training Program, University of Washington, Seattle, WA 98109, USA.
Addetia A; Basic Sciences and Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98109, USA.
Hannon WW; Basic Sciences and Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98109, USA.
Choudhary MC; Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Dingens AS; Basic Sciences and Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Li JZ; Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Bloom JD; Basic Sciences and Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. .; Department of Genome Sciences, University of Washington, Seattle, WA 98109, USA.; Howard Hughes Medical Institute, Seattle, WA 98109, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Feb 19; Vol. 371 (6531), pp. 850-854. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Antibodies, Monoclonal, Humanized/*immunology
Antibodies, Viral/*immunology
COVID-19/*therapy
SARS-CoV-2/*genetics
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*genetics
Spike Glycoprotein, Coronavirus/*immunology
Amino Acid Substitution ; Angiotensin-Converting Enzyme 2/metabolism ; Antibodies, Monoclonal, Humanized/metabolism ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Viral/metabolism ; Antibodies, Viral/therapeutic use ; Cells, Cultured ; Drug Combinations ; Humans ; Immunization, Passive ; Protein Binding ; Protein Domains ; Receptors, Coronavirus/metabolism ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/metabolism
SCR Protocol :
COVID-19 serotherapy
Czasopismo naukowe
Tytuł :
A stable platform for the production of virus-like particles pseudotyped with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein.
Autorzy :
Roy S; CHU de Québec-Université Laval Research Center (Oncology division), Université Laval Cancer Research Center, Québec, Qc, Canada.
Ghani K; CHU de Québec-Université Laval Research Center (Oncology division), Université Laval Cancer Research Center, Québec, Qc, Canada; BioVec Pharma, Québec, Qc, Canada.
de Campos-Lima PO; Boldrini Children's Center, Campinas, Brazil; Functional and Molecular Biology Graduate Program, State University of Campinas, Brazil.
Caruso M; CHU de Québec-Université Laval Research Center (Oncology division), Université Laval Cancer Research Center, Québec, Qc, Canada; BioVec Pharma, Québec, Qc, Canada; Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Université Laval, Québec, Qc, Canada. Electronic address: .
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Źródło :
Virus research [Virus Res] 2021 Apr 02; Vol. 295, pp. 198305. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19 Vaccines/*immunology
Spike Glycoprotein, Coronavirus/*biosynthesis
Virion/*genetics
Cell Line ; Humans ; Moloney murine leukemia virus/genetics ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Vaccines, Synthetic/immunology ; Virion/immunology
Czasopismo naukowe
Tytuł :
Exploring the efficacy of naturally occurring biflavone based antioxidants towards the inhibition of the SARS-CoV-2 spike glycoprotein mediated membrane fusion.
Autorzy :
Mondal S; Department of Chemistry, Rammohan College, 102/1-Raja Rammohan Sarani, Kolkata, 700009, West Bengal, India. Electronic address: .
Karmakar A; Department of Chemistry, Visva-Bharati (Central University), Santiniketan, 731 235, India.
Mallick T; Department of Chemistry, Visva-Bharati (Central University), Santiniketan, 731 235, India.
Begum NA; Department of Chemistry, Visva-Bharati (Central University), Santiniketan, 731 235, India.
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Źródło :
Virology [Virology] 2021 Apr; Vol. 556, pp. 133-139. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antioxidants/*pharmacology
Antiviral Agents/*pharmacology
Biflavonoids/*pharmacology
Spike Glycoprotein, Coronavirus/*metabolism
Virus Internalization/*drug effects
Antioxidants/chemistry ; Antiviral Agents/chemistry ; Biflavonoids/chemistry ; Molecular Docking Simulation ; Molecular Structure ; Protein Binding ; Protein Domains ; SARS-CoV-2/drug effects ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; Spike Glycoprotein, Coronavirus/chemistry
Czasopismo naukowe
Tytuł :
Clinical performance of three fully automated anti-SARS-CoV-2 immunoassays targeting the nucleocapsid or spike proteins.
Autorzy :
Favresse J; Department of Laboratory Medicine, Clinique St-Luc Bouge, Namur, Belgium.; Department of Pharmacy, Namur Research Institute for Life Sciences, University of Namur, Namur, Belgium.
Cadrobbi J; Department of Laboratory Medicine, Clinique St-Luc Bouge, Namur, Belgium.
Eucher C; Department of Laboratory Medicine, Clinique St-Luc Bouge, Namur, Belgium.
Elsen M; Department of Laboratory Medicine, Clinique St-Luc Bouge, Namur, Belgium.
Laffineur K; Department of Laboratory Medicine, Clinique St-Luc Bouge, Namur, Belgium.
Dogné JM; Department of Pharmacy, Namur Research Institute for Life Sciences, University of Namur, Namur, Belgium.
Douxfils J; Department of Pharmacy, Namur Research Institute for Life Sciences, University of Namur, Namur, Belgium.; Qualiblood sa, Namur, Belgium.
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Źródło :
Journal of medical virology [J Med Virol] 2021 Apr; Vol. 93 (4), pp. 2262-2269. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19/*blood
COVID-19/*virology
COVID-19 Testing/*methods
Coronavirus Nucleocapsid Proteins/*blood
Immunoassay/*methods
SARS-CoV-2/*isolation & purification
Spike Glycoprotein, Coronavirus/*blood
Adult ; Aged ; Aged, 80 and over ; Antibodies, Viral/blood ; COVID-19/diagnosis ; COVID-19/immunology ; Coronavirus Nucleocapsid Proteins/immunology ; Cross Reactions ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunoglobulin A/blood ; Immunoglobulin G/blood ; Male ; Middle Aged ; Phosphoproteins/blood ; Phosphoproteins/immunology ; Retrospective Studies ; Sensitivity and Specificity ; Spike Glycoprotein, Coronavirus/analysis ; Spike Glycoprotein, Coronavirus/immunology
Czasopismo naukowe
Tytuł :
COVID-19 outbreak: history, mechanism, transmission, structural studies and therapeutics.
Autorzy :
Yesudhas D; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, 600036, India. .
Srivastava A; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, 600036, India.
Gromiha MM; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, 600036, India. .; School of Computing, Tokyo Tech World Research Hub Initiative (WRHI), Institute of Innovative Research, Tokyo Institute of Technology, Midori-ku, Yokohama, Kanagawa, 226-8503, Japan. .
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Źródło :
Infection [Infection] 2021 Apr; Vol. 49 (2), pp. 199-213. Date of Electronic Publication: 2020 Sep 04.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
COVID-19/*transmission
COVID-19/*virology
SARS-CoV-2/*physiology
Spike Glycoprotein, Coronavirus/*metabolism
Amino Acid Sequence ; Animals ; COVID-19/drug therapy ; COVID-19/epidemiology ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Humans ; Protein Binding ; Protein Folding ; SARS-CoV-2/chemistry ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Virus Internalization
Czasopismo naukowe
Tytuł :
Linear epitope landscape of the SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients.
Autorzy :
Li Y; Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China; College of Life Science, Nankai University, Tianjin 300071, China.
Ma ML; Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Lei Q; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wang F; Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hong W; CAS Key Laboratory of Special Pathogens and Biosafety, Centre for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China; University of Chinese Academy of Sciences, Beijing, China.
Lai DY; Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Hou H; Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xu ZW; Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Zhang B; Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chen H; Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Yu C; Department of Public Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xue JB; Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Zheng YX; Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Wang XN; Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Jiang HW; Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Zhang HN; Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Qi H; Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Guo SJ; Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Zhang Y; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lin X; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yao Z; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wu J; Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Sheng H; Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang Y; CAS Key Laboratory of Special Pathogens and Biosafety, Centre for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China; University of Chinese Academy of Sciences, Beijing, China.
Wei H; CAS Key Laboratory of Special Pathogens and Biosafety, Centre for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China; University of Chinese Academy of Sciences, Beijing, China. Electronic address: .
Sun Z; Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
Fan X; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
Tao SC; Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2021 Mar 30; Vol. 34 (13), pp. 108915. Date of Electronic Publication: 2021 Mar 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Adult ; Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Antigens, Viral/immunology ; COVID-19/epidemiology ; COVID-19/genetics ; China/epidemiology ; Disease Models, Animal ; Epitope Mapping/methods ; Epitopes/immunology ; Female ; Humans ; Immunoglobulin G/immunology ; Male ; Mice ; Mice, Inbred BALB C ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism
Czasopismo naukowe
Tytuł :
Vaccinomic approach for novel multi epitopes vaccine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Autorzy :
Almofti YA; Department of Molecular Biology and Bioinformatics, College of Veterinary Medicine, University of Bahri, Khartoum, Sudan. .
Abd-Elrahman KA; Department of Pharmaceutical Technology, College of Pharmacy, University of Medical Science and Technology (MUST), Khartoum, Sudan.
Eltilib EEM; Department of Molecular Biology and Bioinformatics, College of Veterinary Medicine, University of Bahri, Khartoum, Sudan.
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Źródło :
BMC immunology [BMC Immunol] 2021 Mar 25; Vol. 22 (1), pp. 22. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19 Vaccines*/chemistry
COVID-19 Vaccines*/genetics
COVID-19 Vaccines*/immunology
Epitopes, B-Lymphocyte*/chemistry
Epitopes, B-Lymphocyte*/genetics
Epitopes, B-Lymphocyte*/immunology
Epitopes, T-Lymphocyte*/chemistry
Epitopes, T-Lymphocyte*/genetics
Epitopes, T-Lymphocyte*/immunology
SARS-CoV-2*/chemistry
SARS-CoV-2*/genetics
SARS-CoV-2*/immunology
Spike Glycoprotein, Coronavirus*/chemistry
Spike Glycoprotein, Coronavirus*/genetics
Spike Glycoprotein, Coronavirus*/immunology
Viral Proteins*/chemistry
Viral Proteins*/genetics
Viral Proteins*/immunology
COVID-19/*immunology
B-Lymphocytes/immunology ; COVID-19/prevention & control ; Humans ; Polyproteins/chemistry ; Polyproteins/genetics ; Polyproteins/immunology ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
Topography, Spike Dynamics, and Nanomechanics of Individual Native SARS-CoV-2 Virions.
Autorzy :
Kiss B; Department of Biophysics and Radiation Biology, Semmelweis University, Tűzoltó str. 37-47, Budapest H-1094, Hungary.
Kis Z; National Biosafety Laboratory, National Public Health Center, Albert Flórián Rd 2-6, Budapest H-1097, Hungary.; Department of Medical Microbiology, Semmelweis University, Nagyvárad Sq. 4, Budapest H-1089, Hungary.
Pályi B; National Biosafety Laboratory, National Public Health Center, Albert Flórián Rd 2-6, Budapest H-1097, Hungary.
Kellermayer MSZ; Department of Biophysics and Radiation Biology, Semmelweis University, Tűzoltó str. 37-47, Budapest H-1094, Hungary.; Hungarian Centre of Excellence for Molecular Medicine (HCEMM), In Vivo Imaging Advanced Core Facility, Budapest H-1094, Hungary.
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Źródło :
Nano letters [Nano Lett] 2021 Mar 24; Vol. 21 (6), pp. 2675-2680. Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*virology
SARS-CoV-2/*chemistry
SARS-CoV-2/*physiology
Spike Glycoprotein, Coronavirus/*chemistry
Spike Glycoprotein, Coronavirus/*physiology
Virion/*chemistry
Virion/*physiology
Biomechanical Phenomena ; Hot Temperature ; Humans ; Microscopy, Atomic Force ; Models, Molecular ; Nanostructures/chemistry ; Nanostructures/ultrastructure ; Nanotechnology ; Pandemics ; Protein Conformation ; Protein Stability ; SARS-CoV-2/ultrastructure ; Single Molecule Imaging ; Spike Glycoprotein, Coronavirus/ultrastructure ; Thermodynamics ; Virion/ultrastructure
Czasopismo naukowe
Tytuł :
The impact of receptor-binding domain natural mutations on antibody recognition of SARS-CoV-2.
Autorzy :
Li C; MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Tian X; MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Jia X; Department of Comprehensive Liver Cancer, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Wan J; Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Lu L; MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Jiang S; MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Lan F; Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Lu Y; Department of Comprehensive Liver Cancer, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, China. .
Wu Y; MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China. .
Ying T; MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China. .
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2021 Mar 23; Vol. 6 (1), pp. 132. Date of Electronic Publication: 2021 Mar 23.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Viral*/genetics
Antibodies, Viral*/immunology
COVID-19*/genetics
COVID-19*/immunology
Mutation, Missense*
SARS-CoV-2*/genetics
SARS-CoV-2*/immunology
Spike Glycoprotein, Coronavirus*/genetics
Spike Glycoprotein, Coronavirus*/immunology
Amino Acid Substitution ; Humans ; Protein Domains
Raport
Tytuł :
Single-component, self-assembling, protein nanoparticles presenting the receptor binding domain and stabilized spike as SARS-CoV-2 vaccine candidates.
Autorzy :
He L; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Lin X; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Wang Y; Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA 19140, USA.; Department of Microbiology and Immunology, Temple University, Philadelphia, PA 19140, USA.
Abraham C; Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA 19140, USA.
Sou C; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Ngo T; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Zhang Y; Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA 19140, USA.; Department of Microbiology and Immunology, Temple University, Philadelphia, PA 19140, USA.
Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Zhu J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. .; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
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Źródło :
Science advances [Sci Adv] 2021 Mar 19; Vol. 7 (12). Date of Electronic Publication: 2021 Mar 19 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19 Vaccines*/chemistry
COVID-19 Vaccines*/immunology
COVID-19 Vaccines*/pharmacology
Nanoparticles*/chemistry
Nanoparticles*/therapeutic use
SARS-CoV-2*/chemistry
SARS-CoV-2*/immunology
Spike Glycoprotein, Coronavirus*/chemistry
Spike Glycoprotein, Coronavirus*/immunology
Spike Glycoprotein, Coronavirus*/pharmacology
COVID-19/*immunology
Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/prevention & control ; HEK293 Cells ; Humans ; Immunogenicity, Vaccine ; Mice ; Mice, Inbred BALB C ; Protein Domains
Czasopismo naukowe
Tytuł :
The inhibitory effect of a coronavirus spike protein fragment with ACE2.
Autorzy :
Peter EK; John von Neumann Institute for, Computing and Jülich Supercomputing Centre, Institute for Advanced Simulation, Forschungszentrum Jülich, Jülich, Germany.
Schug A; John von Neumann Institute for, Computing and Jülich Supercomputing Centre, Institute for Advanced Simulation, Forschungszentrum Jülich, Jülich, Germany; Faculty of Biology, University of Duisburg-Essen, Essen, Germany. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2021 Mar 16; Vol. 120 (6), pp. 1001-1010. Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme 2/*metabolism
Peptides/*pharmacology
Spike Glycoprotein, Coronavirus/*antagonists & inhibitors
Amino Acid Sequence ; Angiotensin-Converting Enzyme 2/chemistry ; Humans ; Molecular Dynamics Simulation ; Peptides/chemistry ; Protein Binding/drug effects ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/metabolism
Czasopismo naukowe
Tytuł :
Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution.
Autorzy :
Zhang S; The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, 100084, Beijing, China.
Qiao S; The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, 100084, Beijing, China.
Yu J; The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, 100084, Beijing, China.
Zeng J; The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, 100084, Beijing, China.
Shan S; Center for Global Health and Infectious Diseases, Comprehensive AIDS Research Center, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing, China.
Tian L; The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, 100084, Beijing, China.
Lan J; The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, 100084, Beijing, China.
Zhang L; Center for Global Health and Infectious Diseases, Comprehensive AIDS Research Center, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing, China.
Wang X; The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, 100084, Beijing, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 11; Vol. 12 (1), pp. 1607. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*virology
Chiroptera/*virology
Coronavirus/*chemistry
Coronavirus/*genetics
Pangolins/*virology
SARS-CoV-2/*chemistry
SARS-CoV-2/*genetics
Spike Glycoprotein, Coronavirus/*chemistry
Spike Glycoprotein, Coronavirus/*genetics
Amino Acid Sequence ; Angiotensin-Converting Enzyme 2/chemistry ; Animals ; COVID-19/epidemiology ; COVID-19/transmission ; Cryoelectron Microscopy ; Evolution, Molecular ; Host Microbial Interactions ; Humans ; Models, Molecular ; Pandemics ; Protein Domains ; Sequence Homology, Amino Acid ; Species Specificity ; Spike Glycoprotein, Coronavirus/ultrastructure
Czasopismo naukowe
Tytuł :
Rapid SARS-CoV-2 Spike Protein Detection by Carbon Nanotube-Based Near-Infrared Nanosensors.
Autorzy :
Pinals RL; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.
Ledesma F; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.
Yang D; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.
Navarro N; Department of Chemistry, University of California, Berkeley, California 94720, United States.
Jeong S; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.
Pak JE; Chan Zuckerberg Biohub, San Francisco, California 94158, United States.
Kuo L; Wadsworth Center, New York State Department of Health, Slingerlands, New York 12159, United States.
Chuang YC; Leadgene Biomedical Inc., Tainan 71042, Taiwan.; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Cheng YW; Leadgene Biomedical Inc., Tainan 71042, Taiwan.
Sun HY; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Landry MP; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.; Chan Zuckerberg Biohub, San Francisco, California 94158, United States.; Innovative Genomics Institute (IGI), Berkeley, California 94720, United States.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, California 94720, United States.
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Źródło :
Nano letters [Nano Lett] 2021 Mar 10; Vol. 21 (5), pp. 2272-2280. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Nanotubes, Carbon*
Biosensing Techniques/*methods
COVID-19/*diagnosis
COVID-19/*virology
COVID-19 Testing/*methods
SARS-CoV-2/*chemistry
Spike Glycoprotein, Coronavirus/*analysis
Angiotensin-Converting Enzyme 2/metabolism ; Antigens, Viral/analysis ; Humans ; Immobilized Proteins/metabolism ; Nanotechnology ; Pandemics ; Protein Binding ; SARS-CoV-2/immunology ; Spectrometry, Fluorescence ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/metabolism
Czasopismo naukowe
Tytuł :
SARS-CoV-2 spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity.
Autorzy :
Petruk G; Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE-22184 Lund, Sweden.
Puthia M; Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE-22184 Lund, Sweden.
Petrlova J; Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE-22184 Lund, Sweden.
Samsudin F; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore 138671, Singapore.
Strömdahl AC; Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE-22184 Lund, Sweden.
Cerps S; Unit of Respiratory Immunopharmacology, Department of Experimental Medicine, Lund University, SE-22184 Lund, Sweden.
Uller L; Unit of Respiratory Immunopharmacology, Department of Experimental Medicine, Lund University, SE-22184 Lund, Sweden.
Kjellström S; Division of Mass Spectrometry, Department of Clinical Sciences, Lund University, SE-22184 Lund, Sweden.
Bond PJ; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore 138671, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore.
Schmidtchen AA; Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE-22184 Lund, Sweden.; Copenhagen Wound Healing Center, Bispebjerg Hospital, Department of Biomedical Sciences, University of Copenhagen, DK-2400 Copenhagen, Denmark.; Dermatology, Skåne University Hospital, SE-22185 Lund, Sweden.
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Źródło :
Journal of molecular cell biology [J Mol Cell Biol] 2021 Mar 10; Vol. 12 (12), pp. 916-932.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
SARS-CoV-2*/immunology
SARS-CoV-2*/pathogenicity
SARS-CoV-2*/physiology
COVID-19/*complications
Inflammation/*etiology
Lipopolysaccharides/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Animals ; Binding Sites ; COVID-19/immunology ; COVID-19/virology ; Cytokine Release Syndrome/etiology ; Cytokine Release Syndrome/immunology ; Disease Models, Animal ; Gram-Negative Bacterial Infections/complications ; Gram-Negative Bacterial Infections/immunology ; Humans ; In Vitro Techniques ; Lipid A/chemistry ; Lipid A/immunology ; Lipid A/metabolism ; Lipopolysaccharides/chemistry ; Lipopolysaccharides/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Models, Immunological ; Models, Molecular ; Molecular Docking Simulation ; Protein Binding ; Protein Interaction Domains and Motifs ; Respiratory Distress Syndrome/etiology ; Risk Factors ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/immunology
Czasopismo naukowe
Tytuł :
Analogue discovery of safer alternatives to HCQ and CQ drugs for SAR-CoV-2 by computational design.
Autorzy :
Sinha M; Computational Toxicology Facility, CSIR- Indian Institute of Toxicology Research, Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India.
Gupta A; Computational Toxicology Facility, CSIR- Indian Institute of Toxicology Research, Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India.
Gupta S; Computational Toxicology Facility, CSIR- Indian Institute of Toxicology Research, Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India.
Singh P; Computational Toxicology Facility, CSIR- Indian Institute of Toxicology Research, Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India.
Pandit S; Computational Toxicology Facility, CSIR- Indian Institute of Toxicology Research, Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India.
Chauhan SS; Computational Toxicology Facility, CSIR- Indian Institute of Toxicology Research, Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India.
Parthasarathi R; Computational Toxicology Facility, CSIR- Indian Institute of Toxicology Research, Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India. Electronic address: .
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Źródło :
Computers in biology and medicine [Comput Biol Med] 2021 Mar; Vol. 130, pp. 104222. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery*
Hydroxychloroquine*/analogs & derivatives
Hydroxychloroquine*/chemistry
Molecular Docking Simulation*
Molecular Dynamics Simulation*
Spike Glycoprotein, Coronavirus*/antagonists & inhibitors
Spike Glycoprotein, Coronavirus*/chemistry
COVID-19/*drug therapy
SARS-CoV-2/*chemistry
Humans
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Development and characterization of an indirect ELISA to detect SARS-CoV-2 spike protein-specific antibodies.
Autorzy :
Krähling V; Institute of Virology, Philipps University Marburg, Marburg, Germany; German Center for Infection Research (DZIF), Partner Site Gießen-Marburg-Langen, Marburg, Germany. Electronic address: .
Halwe S; Institute of Virology, Philipps University Marburg, Marburg, Germany; German Center for Infection Research (DZIF), Partner Site Gießen-Marburg-Langen, Marburg, Germany.
Rohde C; Institute of Virology, Philipps University Marburg, Marburg, Germany; German Center for Infection Research (DZIF), Partner Site Gießen-Marburg-Langen, Marburg, Germany.
Becker D; Institute of Virology, Philipps University Marburg, Marburg, Germany; German Center for Infection Research (DZIF), Partner Site Gießen-Marburg-Langen, Marburg, Germany.
Berghöfer S; Institute of Virology, Philipps University Marburg, Marburg, Germany.
Dahlke C; First Department of Medicine, Division of Infectious Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; German Center for Infection Research, Hamburg-Lübeck-Borstel-Riems, Germany.
Eickmann M; Institute of Virology, Philipps University Marburg, Marburg, Germany.
Ercanoglu MS; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Gieselmann L; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Herwig A; Institute of Virology, Philipps University Marburg, Marburg, Germany.
Kupke A; Institute of Virology, Philipps University Marburg, Marburg, Germany; German Center for Infection Research (DZIF), Partner Site Gießen-Marburg-Langen, Marburg, Germany.
Müller H; Institute of Virology, Philipps University Marburg, Marburg, Germany.
Neubauer-Rädel P; Institute of Virology, Philipps University Marburg, Marburg, Germany.
Klein F; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.
Keller C; Institute of Virology, Philipps University Marburg, Marburg, Germany; Institute of Virology, University Hospital Giessen and Marburg, Marburg, Germany.
Becker S; Institute of Virology, Philipps University Marburg, Marburg, Germany; German Center for Infection Research (DZIF), Partner Site Gießen-Marburg-Langen, Marburg, Germany.
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Źródło :
Journal of immunological methods [J Immunol Methods] 2021 Mar; Vol. 490, pp. 112958. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*diagnosis
COVID-19 Serological Testing/*methods
Epithelial Cells/*metabolism
SARS-CoV-2/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Animals ; Antibodies, Neutralizing/blood ; Chlorocebus aethiops ; Enzyme Assays ; Enzyme-Linked Immunosorbent Assay ; Humans ; Reproducibility of Results ; Sensitivity and Specificity ; Seroconversion ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Vero Cells
Czasopismo naukowe
Tytuł :
Improved production of SARS-CoV-2 spike receptor-binding domain (RBD) for serology assays.
Autorzy :
Mehalko J; Protein Expression Laboratory, NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
Drew M; Protein Expression Laboratory, NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
Snead K; Protein Expression Laboratory, NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
Denson JP; Protein Expression Laboratory, NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
Wall V; Protein Expression Laboratory, NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
Taylor T; Protein Expression Laboratory, NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
Sadtler K; Section on Immuno-Engineering, National Institute for Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20894, USA.
Messing S; Protein Expression Laboratory, NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
Gillette W; Protein Expression Laboratory, NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
Esposito D; Protein Expression Laboratory, NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA. Electronic address: .
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Źródło :
Protein expression and purification [Protein Expr Purif] 2021 Mar; Vol. 179, pp. 105802. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms :
COVID-19/*blood
Protein Domains/*genetics
SARS-CoV-2/*isolation & purification
Spike Glycoprotein, Coronavirus/*isolation & purification
Antibodies, Viral/immunology ; COVID-19/genetics ; COVID-19/virology ; Enzyme-Linked Immunosorbent Assay ; Humans ; Protein Binding/genetics ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/blood ; Spike Glycoprotein, Coronavirus/genetics
Czasopismo naukowe
Tytuł :
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.
Autorzy :
Johnson BA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Xie X; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Bailey AL; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Kalveram B; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Lokugamage KG; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Muruato A; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Zou J; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Zhang X; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Juelich T; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Smith JK; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Zhang L; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Bopp N; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Schindewolf C; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Vu M; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Vanderheiden A; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Winkler ES; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Swetnam D; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Plante JA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Aguilar P; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Plante KS; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Popov V; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Lee B; Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Weaver SC; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
Suthar MS; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Yerkes National Primate Research Center, Atlanta, GA, USA.
Routh AL; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Ren P; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Ku Z; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, USA.
An Z; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, USA.
Debbink K; Department of Natural Sciences Bowie State University, Bowie, MD, USA.
Diamond MS; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.
Shi PY; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
Freiberg AN; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
Menachery VD; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA. .; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA. .
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Źródło :
Nature [Nature] 2021 Mar; Vol. 591 (7849), pp. 293-299. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Mutation*
COVID-19/*virology
Furin/*metabolism
SARS-CoV-2/*genetics
SARS-CoV-2/*pathogenicity
Spike Glycoprotein, Coronavirus/*chemistry
Spike Glycoprotein, Coronavirus/*genetics
Amino Acid Sequence ; Animals ; Antibodies, Neutralizing/immunology ; COVID-19/pathology ; COVID-19/physiopathology ; Cell Line ; Chlorocebus aethiops ; Cricetinae ; Female ; Humans ; Lung Diseases/pathology ; Lung Diseases/physiopathology ; Lung Diseases/virology ; Male ; Mice ; Mice, Transgenic ; Models, Molecular ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Proteolysis ; SARS-CoV-2/chemistry ; SARS-CoV-2/metabolism ; Serine Endopeptidases/metabolism ; Spike Glycoprotein, Coronavirus/metabolism ; Vero Cells ; Virus Replication/genetics
Czasopismo naukowe
Tytuł :
Incomplete humoral response including neutralizing antibodies in asymptomatic to mild COVID-19 patients in Japan.
Autorzy :
Takeshita M; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, 160-8582, Japan. Electronic address: .
Nishina N; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Moriyama S; Department of Immunology, National Institute of Infectious Diseases, Tokyo, 160-8582, Japan.
Takahashi Y; Department of Immunology, National Institute of Infectious Diseases, Tokyo, 160-8582, Japan.
Uwamino Y; Department of Laboratory Medicine, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Nagata M; Clinical Laboratory, Keio University Hospital, Tokyo, 160-8582, Japan.
Aoki W; Clinical Laboratory, Keio University Hospital, Tokyo, 160-8582, Japan.
Masaki K; Division of Pulmonary Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Ishii M; Division of Pulmonary Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Saya H; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Kondo Y; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Kaneko Y; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Suzuki K; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Fukunaga K; Division of Pulmonary Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Takeuchi T; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, 160-8582, Japan.
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Corporate Authors :
Keio Donner project
Źródło :
Virology [Virology] 2021 Mar; Vol. 555, pp. 35-43. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing/*blood
Antibodies, Viral/*blood
COVID-19/*immunology
Coronavirus Nucleocapsid Proteins/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Adult ; Angiotensin-Converting Enzyme 2/metabolism ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Asymptomatic Infections ; COVID-19/diagnosis ; COVID-19/physiopathology ; COVID-19 Nucleic Acid Testing ; Coronavirus Nucleocapsid Proteins/chemistry ; Female ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Japan ; Male ; Middle Aged ; Phosphoproteins/chemistry ; Phosphoproteins/immunology ; Protein Domains ; Severity of Illness Index ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/metabolism
Czasopismo naukowe
Tytuł :
Identification of SARS-CoV-2 Nucleocapsid and Spike T-Cell Epitopes for Assessing T-Cell Immunity.
Autorzy :
Lee E; Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia .; Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
Sandgren K; Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia.; Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
Duette G; Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia.; Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
Stylianou VV; Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia.; Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
Khanna R; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.; QIMR Berghofer Centre for Immunotherapy and Vaccine Development, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Eden JS; Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia.; Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.; Centre for Infectious Diseases and Microbiology, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia.; Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Westmead, New South Wales, Australia.
Blyth E; Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.; Centre for Cancer Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia.; BMT and Cell Therapies Program, Westmead Hospital, Westmead, New South Wales, Australia.
Gottlieb D; Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.; Centre for Cancer Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia.; BMT and Cell Therapies Program, Westmead Hospital, Westmead, New South Wales, Australia.
Cunningham AL; Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia.; Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
Palmer S; Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia.; Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
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Źródło :
Journal of virology [J Virol] 2021 Feb 24; Vol. 95 (6). Date of Electronic Publication: 2021 Feb 24 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Coronavirus Nucleocapsid Proteins/*immunology
Epitopes, T-Lymphocyte/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Amino Acid Sequence ; Antigen Presentation ; COVID-19/blood ; COVID-19/immunology ; Computational Biology ; Coronavirus/classification ; Coronavirus/immunology ; Coronavirus Nucleocapsid Proteins/chemistry ; Coronavirus Nucleocapsid Proteins/genetics ; Epitopes, T-Lymphocyte/chemistry ; Epitopes, T-Lymphocyte/genetics ; HLA Antigens/immunology ; Humans ; Immunity, Cellular ; Mutation ; Phosphoproteins/chemistry ; Phosphoproteins/genetics ; Phosphoproteins/immunology ; Protein Binding ; SARS-CoV-2/genetics ; Species Specificity ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics
Czasopismo naukowe

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