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Tytuł :
[Effects of ophiopogonin D on fatty acid metabolic enzymes in cardiomyocytes].
Autorzy :
Tang XL; Institute of Radiation Medicine,Academy of Military Medical Sciences Beijing 100850,China.
Lin Y; Institute of Radiation Medicine,Academy of Military Medical Sciences Beijing 100850,China.
Wang YG; Institute of Radiation Medicine,Academy of Military Medical Sciences Beijing 100850,China.
Gao Y; Institute of Radiation Medicine,Academy of Military Medical Sciences Beijing 100850,China.
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Źródło :
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2021 Jul; Vol. 46 (14), pp. 3672-3677.
Typ publikacji :
Journal Article
MeSH Terms :
Saponins*/pharmacology
Spirostans*/pharmacology
Fatty Acids ; Humans ; Myocytes, Cardiac
Czasopismo naukowe
Tytuł :
Spirostanol Sapogenins and Saponins from Convallaria majalis L. Structural Characterization by 2D NMR, Theoretical GIAO DFT Calculations and Molecular Modeling.
Autorzy :
Dąbrowska-Balcerzak K; Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
Nartowska J; Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
Wawer I; Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
Siudem P; Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
Paradowska K; Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 May 18; Vol. 26 (10). Date of Electronic Publication: 2021 May 18.
Typ publikacji :
Journal Article
MeSH Terms :
Carbon-13 Magnetic Resonance Spectroscopy*
Density Functional Theory*
Models, Molecular*
Proton Magnetic Resonance Spectroscopy*
Convallaria/*chemistry
Sapogenins/*analysis
Saponins/*analysis
Spirostans/*analysis
Molecular Docking Simulation ; Sapogenins/chemistry ; Sapogenins/isolation & purification ; Saponins/chemistry ; Saponins/isolation & purification ; Spirostans/chemistry ; Spirostans/isolation & purification
Czasopismo naukowe
Tytuł :
Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice.
Autorzy :
Yu YY; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Cui SC; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Zheng TN; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Ma HJ; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Xie ZF; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Jiang HW; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Li YF; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Zhu KX; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Huang CG; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Li J; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. .
Li JY; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. .
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Źródło :
Acta pharmacologica Sinica [Acta Pharmacol Sin] 2021 Feb; Vol. 42 (2), pp. 272-281. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Insulin Resistance*
Inflammation/*drug therapy
Obesity/*drug therapy
Spirostans/*pharmacology
3T3-L1 Cells ; Adipocytes/drug effects ; Adipocytes/pathology ; Adipose Tissue/drug effects ; Animals ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/pharmacology ; Diet, High-Fat ; Disease Models, Animal ; Inflammation/pathology ; Macrophages/drug effects ; Macrophages/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Obesity/complications ; RAW 264.7 Cells ; Spirostans/administration & dosage
Czasopismo naukowe
Tytuł :
Mechanisms dissection of the combination GRS derived from ShengMai preparations for the treatment of myocardial ischemia/reperfusion injury.
Autorzy :
Yang W; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, PR China. Electronic address: .
Lai Q; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, PR China. Electronic address: .
Zhang L; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, PR China. Electronic address: .
Zhang Y; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, PR China. Electronic address: .
Zhang Y; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, PR China. Electronic address: .
Yu B; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, PR China. Electronic address: .
Li F; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, PR China. Electronic address: .
Kou J; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, PR China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Jan 10; Vol. 264, pp. 113381. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Journal Article
MeSH Terms :
Cyclooctanes/*administration & dosage
Drugs, Chinese Herbal/*administration & dosage
Ginsenosides/*administration & dosage
Lignans/*administration & dosage
Myocardial Reperfusion Injury/*drug therapy
Polycyclic Compounds/*administration & dosage
Spirostans/*administration & dosage
Animals ; Cell Line ; Cell Survival/drug effects ; Cell Survival/physiology ; Cyclooctanes/isolation & purification ; Drug Combinations ; Drugs, Chinese Herbal/isolation & purification ; Ginsenosides/isolation & purification ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/metabolism ; Lignans/isolation & purification ; Male ; Mice ; Mice, Inbred ICR ; Myocardial Reperfusion Injury/metabolism ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Polycyclic Compounds/isolation & purification ; Rats ; Spirostans/isolation & purification ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Differences in the Hemolytic Behavior of Two Isomers in Ophiopogon japonicus In Vitro and In Vivo and Their Risk Warnings.
Autorzy :
Xu HH; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Jiang ZH; Jiangxi Province Key Laboratory of Molecular Medicine, Nanchang 330006, China.
Sun YT; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Qiu LZ; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Xu LL; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.; College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China.
Tang XL; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Ma ZC; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Gao Y; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
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Źródło :
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2020 Dec 13; Vol. 2020, pp. 8870656. Date of Electronic Publication: 2020 Dec 13 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Hemolysis/*drug effects
Ophiopogon/*chemistry
Saponins/*pharmacology
Spirostans/*pharmacology
Animals ; Antioxidants/adverse effects ; Antioxidants/chemistry ; Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Blood Cells/drug effects ; Blood Cells/metabolism ; Drugs, Chinese Herbal/adverse effects ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Isomerism ; Male ; Mice ; Oxidation-Reduction/drug effects ; Proteome/drug effects ; Proteome/metabolism ; Rabbits ; Rats ; Rats, Wistar ; Risk Assessment ; Saponins/adverse effects ; Saponins/chemistry ; Saponins/isolation & purification ; Spirostans/adverse effects ; Spirostans/chemistry ; Spirostans/isolation & purification ; Toxicity Tests, Acute
Czasopismo naukowe
Tytuł :
Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC/MS.
Autorzy :
Xie L; School of Pharmacy, Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, Shenyang 110016, China.
Lee DY; Mailman Research Center, McLean Hospital, Harvard Medical School, Boston, MA, United States. Electronic address: .
Shang Y; School of Pharmacy, Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, Shenyang 110016, China.
Cao X; School of Pharmacy, Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wang S; School of Pharmacy, Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, Shenyang 110016, China.
Liao J; School of Pharmacy, Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhang T; School of Pharmacy, Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: .
Dai R; School of Pharmacy, Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2020 Oct; Vol. 77, pp. 153284. Date of Electronic Publication: 2020 Jul 11.
Typ publikacji :
Journal Article
MeSH Terms :
Anemarrhena/*chemistry
Cyclooxygenase 2 Inhibitors/*pharmacology
Glycosides/*chemistry
Lipoxygenase Inhibitors/*pharmacology
Spirostans/*chemistry
Sterols/*chemistry
Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Arachidonate 5-Lipoxygenase/chemistry ; Arachidonate 5-Lipoxygenase/genetics ; Arachidonate 5-Lipoxygenase/metabolism ; Chromatography, High Pressure Liquid ; Cyclooxygenase 2/chemistry ; Cyclooxygenase 2/genetics ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/chemistry ; Drug Evaluation, Preclinical ; Glycosides/pharmacology ; Inflammation/drug therapy ; Lipoxygenase Inhibitors/chemistry ; Mass Spectrometry ; Molecular Docking Simulation ; Rats ; Rhizome/chemistry ; Saponins/chemistry ; Saponins/pharmacology ; Spirostans/pharmacology ; Steroids/chemistry ; Steroids/pharmacology ; Sterols/pharmacology ; Ultrafiltration
Czasopismo naukowe
Tytuł :
Identification and Structural Analysis of Spirostanol Saponin from Yucca schidigera by Integrating Silica Gel Column Chromatography and Liquid Chromatography/Mass Spectrometry Analysis.
Autorzy :
Ruan J; Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.
Qu L; Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.; Institute of TCM, Yunnan University of Traditional Chinese Medicine, 1076 Yuhua Road, Chenggong District, Kunming 650500, China.
Zhao W; Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.
Gao C; Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.
Huang P; Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.
Zheng D; Institute of TCM, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.
Han L; Institute of TCM, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.
Yu H; Institute of TCM, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.
Zhang Z; Institute of TCM, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.
Zhang Y; Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.; Institute of TCM, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.
Wang T; Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.; Institute of TCM, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Aug 24; Vol. 25 (17). Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Journal Article
MeSH Terms :
Saponins*/chemistry
Saponins*/isolation & purification
Spirostans*/chemistry
Spirostans*/isolation & purification
Plant Extracts/*chemistry
Yucca/*chemistry
Chromatography, High Pressure Liquid ; Silica Gel ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
A Total of Eight Novel Steroidal Glycosides Based on Spirostan, Furostan, Pseudofurostan, and Cholestane from the Leaves of Cestrum newellii .
Autorzy :
Iguchi T; School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Takahashi N; School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Mimaki Y; School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Sep 28; Vol. 25 (19). Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article
MeSH Terms :
Cestrum/*chemistry
Cholestanes/*analysis
Glycosides/*analysis
Phytosterols/*analysis
Spirostans/*analysis
Carbon-13 Magnetic Resonance Spectroscopy ; Cholestanes/chemistry ; Glycosides/chemistry ; Phytosterols/chemistry ; Proton Magnetic Resonance Spectroscopy ; Spirostans/chemistry
Czasopismo naukowe
Tytuł :
Sarsasapogenin Suppresses RANKL-Induced Osteoclastogenesis in vitro and Prevents Lipopolysaccharide-Induced Bone Loss in vivo.
Autorzy :
Peng J; Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Guangxi 530021, People's Republic of China.
Zhao K; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, People's Republic of China.
Zhu J; Department of Clinical Medicine, Medical College of Shaoxing University, Shaoxing, Zhejiang 312000, People's Republic of China.
Wang Y; Department of Orthopaedics, Shaoxing People's Hospital, Zhejiang University School of Medicine, Shaoxing 312000, Zhejiang, People's Republic of China.; Department of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Sun P; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, People's Republic of China.
Yang Q; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, People's Republic of China.
Zhang T; Department of Orthopaedics, Shaoxing People's Hospital, Zhejiang University School of Medicine, Shaoxing 312000, Zhejiang, People's Republic of China.
Han W; Department of Orthopaedics, Shaoxing People's Hospital, Zhejiang University School of Medicine, Shaoxing 312000, Zhejiang, People's Republic of China.
Hu W; Department of Orthopaedics, Shaoxing People's Hospital, Zhejiang University School of Medicine, Shaoxing 312000, Zhejiang, People's Republic of China.
Yang W; Department of Orthopaedics, Shaoxing People's Hospital, Zhejiang University School of Medicine, Shaoxing 312000, Zhejiang, People's Republic of China.
Ruan J; Department of Orthopaedics, Taizhou Municipal Hospital, Taizhou 318000, Zhejiang, Republic of China.
Qian Y; Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Guangxi 530021, People's Republic of China.; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, People's Republic of China.; Department of Orthopaedics, Shaoxing People's Hospital, Zhejiang University School of Medicine, Shaoxing 312000, Zhejiang, People's Republic of China.
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Źródło :
Drug design, development and therapy [Drug Des Devel Ther] 2020 Aug 24; Vol. 14, pp. 3435-3447. Date of Electronic Publication: 2020 Aug 24 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Lipopolysaccharides/*antagonists & inhibitors
Osteoclasts/*drug effects
Osteogenesis/*drug effects
Osteolysis/*prevention & control
RANK Ligand/*antagonists & inhibitors
Spirostans/*pharmacology
Animals ; Cells, Cultured ; Dose-Response Relationship, Drug ; Lipopolysaccharides/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Conformation ; Osteoclasts/metabolism ; Osteoclasts/pathology ; Osteolysis/pathology ; RANK Ligand/metabolism ; Spirostans/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Synthesis and anti-tumour, immunomodulating activity of diosgenin and tigogenin conjugates.
Autorzy :
Michalak O; Łukasiewicz Research Network-Pharmaceutical Research Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland. Electronic address: .
Krzeczyński P; Łukasiewicz Research Network-Pharmaceutical Research Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland.
Cieślak M; Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Łódź, Poland.
Cmoch P; Institute of Organic Chemistry, Polish Academy of Sciences, 44/52 Kasprzaka Str., 01-224 Warsaw, Poland.
Cybulski M; Łukasiewicz Research Network-Pharmaceutical Research Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland.
Królewska-Golińska K; Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Łódź, Poland.
Kaźmierczak-Barańska J; Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Łódź, Poland.
Trzaskowski B; Chemical and Biological Systems Simulation Lab, Center of New Technologies, University of Warsaw, 2C Banacha Str., 02-097 Warsaw, Poland.
Ostrowska K; Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland.
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Źródło :
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2020 Apr; Vol. 198, pp. 105573. Date of Electronic Publication: 2020 Feb 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Diosgenin/*analogs & derivatives
Diosgenin/*pharmacology
Spirostans/*chemistry
Spirostans/*pharmacology
Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Antineoplastic Agents/chemical synthesis ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Diosgenin/chemical synthesis ; Drug Design ; Drug Screening Assays, Antitumor ; Human Umbilical Vein Endothelial Cells ; Humans ; Immunologic Factors/chemical synthesis ; Immunologic Factors/chemistry ; Immunologic Factors/pharmacology ; MCF-7 Cells ; Molecular Docking Simulation ; PC-3 Cells ; Spirostans/chemical synthesis
Czasopismo naukowe
Tytuł :
Ophiopogonin D alleviates diabetic myocardial injuries by regulating mitochondrial dynamics.
Autorzy :
Li W; School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: .
Ji L; School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: .
Tian J; School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: .
Tang W; School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: .
Shan X; Public Laboratory Platform, School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: .
Zhao P; Public Laboratory Platform, School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: .
Chen H; School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: .
Zhang C; Department of Pathology, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: .
Xu M; Department of Physiology, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: .
Lu R; School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: .
Guo W; Department of Pathology, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 May 10; Vol. 271, pp. 113853. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article
MeSH Terms :
Cardiotonic Agents/*pharmacology
Cardiotonic Agents/*therapeutic use
Diabetic Cardiomyopathies/*prevention & control
Mitochondrial Dynamics/*drug effects
Saponins/*pharmacology
Saponins/*therapeutic use
Spirostans/*pharmacology
Spirostans/*therapeutic use
Animals ; Apoptosis/drug effects ; Blood Glucose/drug effects ; Body Weight/drug effects ; Calcineurin/metabolism ; Calcium/metabolism ; Cell Line ; Cell Survival/drug effects ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Diabetic Cardiomyopathies/etiology ; Diabetic Cardiomyopathies/metabolism ; Diabetic Cardiomyopathies/pathology ; Disease Models, Animal ; Dynamins/antagonists & inhibitors ; Lipids/blood ; Liver/drug effects ; Male ; Mice ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Myocytes, Cardiac/drug effects ; Palmitic Acid/toxicity ; Rats
Czasopismo naukowe
Tytuł :
Outlining In Vitro and In Silico Cholinesterase Inhibitory Activity of Twenty-Four Natural Products of Various Chemical Classes: Smilagenin, Kokusaginine, and Methyl Rosmarinate as Emboldening Inhibitors.
Autorzy :
Senol Deniz FS; Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey.
Eren G; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey.
Orhan IE; Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey.
Sener B; Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey.
Ozgen U; Department of Pharmacognosy, Faculty of Pharmacy, Karadeniz Technical University, 61080 Trabzon, Turkey.
Aldaba R; Department of Pharmacognosy, Faculty of Pharmacy, Near East University, 99138 Nicosia, Turkey.
Calis I; Department of Pharmacognosy, Faculty of Pharmacy, Near East University, 99138 Nicosia, Turkey.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Apr 01; Vol. 26 (7). Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Products/*chemistry
Biological Products/*pharmacology
Cholinesterase Inhibitors/*chemistry
Cholinesterase Inhibitors/*pharmacology
Binding Sites ; Biological Products/isolation & purification ; Cholinesterase Inhibitors/isolation & purification ; Furans/chemistry ; Furans/pharmacology ; Inhibitory Concentration 50 ; Molecular Conformation ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Structure ; Protein Binding ; Quinolines/chemistry ; Quinolines/pharmacology ; Spirostans/chemistry ; Spirostans/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Combination of Sarsasapogenin and Fluticasone attenuates ovalbumin-induced airway inflammation in a mouse asthma model.
Autorzy :
Ingawale DK; Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, India.
Mandlik SK; Sinhgad College of Pharmacy, Pune, India.
Patel SS; Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, India.
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Źródło :
Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 2020 Apr; Vol. 42 (2), pp. 128-137. Date of Electronic Publication: 2020 Feb 18.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Asthmatic Agents/*therapeutic use
Asthma/*drug therapy
Drugs, Chinese Herbal/*therapeutic use
Fluticasone/*therapeutic use
Lung/*drug effects
Spirostans/*therapeutic use
Animals ; Anti-Asthmatic Agents/administration & dosage ; Asthma/blood ; Asthma/immunology ; Cytokines/metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Drugs, Chinese Herbal/administration & dosage ; Female ; Fluticasone/administration & dosage ; Immunoglobulin E/blood ; Lung/immunology ; Male ; Mice ; Mice, Inbred BALB C ; Ovalbumin/immunology ; Oxidative Stress/drug effects ; Oxidative Stress/immunology ; Spirostans/administration & dosage
Czasopismo naukowe
Tytuł :
A validated UPLC-MS/MS method for quantitative determination of a potent neuroprotective agent Sarsasapogenin-AA13 in rat plasma: Application to pharmacokinetic studies.
Autorzy :
Pei L; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ye Y; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhao W; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ye Q; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ge S; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jiang ZW; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Liang XQ; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Gan HX; School of Pharmacy, East China University of Science and Technology, Shanghai, China.
Ma L; School of Pharmacy, East China University of Science and Technology, Shanghai, China.
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Źródło :
Biomedical chromatography : BMC [Biomed Chromatogr] 2020 Mar; Vol. 34 (3), pp. e4775. Date of Electronic Publication: 2020 Jan 17.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatography, High Pressure Liquid/*methods
Neuroprotective Agents/*blood
Spirostans/*blood
Tandem Mass Spectrometry/*methods
Animals ; Limit of Detection ; Linear Models ; Male ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Spirostans/chemistry ; Spirostans/pharmacokinetics
Czasopismo naukowe
Tytuł :
Spirostanol and sesquiterpenoid glycosides from the rhizomes of Trillium tschonoskii.
Autorzy :
Li D; State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Yan H; State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Wang J; State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Yu Q; Institute of Medicinal Chemistry and Chemical Biology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Ni W; State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
An LK; Institute of Medicinal Chemistry and Chemical Biology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Qin XJ; State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: .
Liu HY; State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: .
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Źródło :
Steroids [Steroids] 2020 Mar; Vol. 155, pp. 108569. Date of Electronic Publication: 2019 Dec 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Glycosides/*pharmacology
Rhizome/*chemistry
Sesquiterpenes/*pharmacology
Spirostans/*pharmacology
Trillium/*chemistry
Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Glycosides/chemistry ; Glycosides/isolation & purification ; HCT116 Cells ; HeLa Cells ; Humans ; Models, Molecular ; Molecular Conformation ; Sesquiterpenes/chemistry ; Sesquiterpenes/isolation & purification ; Spirostans/chemistry ; Spirostans/isolation & purification ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Sarsasapogenin: A steroidal saponin from Asparagus racemosus as multi target directed ligand in Alzheimer's disease.
Autorzy :
Kashyap P; University School of Biotechnology, GGS Indraprastha University, Dwarka, Sector 16C, New Delhi 110078, India.
Muthusamy K; Indian Pharmacopoeia Commission, Ministry of Health and Family Welfare, Sector 23, Raj Nagar, Ghaziabad, Uttar Pradesh 201002, India.
Niranjan M; Indian Pharmacopoeia Commission, Ministry of Health and Family Welfare, Sector 23, Raj Nagar, Ghaziabad, Uttar Pradesh 201002, India.
Trikha S; Indian Pharmacopoeia Commission, Ministry of Health and Family Welfare, Sector 23, Raj Nagar, Ghaziabad, Uttar Pradesh 201002, India.
Kumar S; University School of Biotechnology, GGS Indraprastha University, Dwarka, Sector 16C, New Delhi 110078, India. Electronic address: .
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Źródło :
Steroids [Steroids] 2020 Jan; Vol. 153, pp. 108529. Date of Electronic Publication: 2019 Oct 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*drug therapy
Antioxidants/*pharmacology
Asparagus Plant/*chemistry
Enzyme Inhibitors/*pharmacology
Neuroprotective Agents/*pharmacology
Spirostans/*pharmacology
Acetylcholinesterase/metabolism ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Animals ; Antioxidants/chemistry ; Antioxidants/isolation & purification ; Aspartic Acid Endopeptidases/antagonists & inhibitors ; Aspartic Acid Endopeptidases/metabolism ; Biphenyl Compounds/antagonists & inhibitors ; Butyrylcholinesterase/metabolism ; Cell Survival/drug effects ; Electrophorus ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/isolation & purification ; Horses ; Humans ; Ligands ; Monoamine Oxidase/metabolism ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/isolation & purification ; Oxidative Stress/drug effects ; PC12 Cells ; Picrates/antagonists & inhibitors ; Rats ; Spirostans/chemistry ; Spirostans/isolation & purification
Czasopismo naukowe
Tytuł :
Sarsasapogenin ameliorates diabetes-associated memory impairment and neuroinflammation through down-regulation of PAR-1 receptor.
Autorzy :
Kong L; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Liu Y; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Zhang YM; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Li Y; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Gou LS; Center for Genetic Medicine, Xuzhou Maternity and Child Health Care Hospital, Xuzhou, Jiangsu, China.
Ma TF; Institute for Stem Cell and Neural Regeneration; Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, China.
Liu YW; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.; Department of Pharmacology, School of Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
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Źródło :
Phytotherapy research : PTR [Phytother Res] 2021 Jun; Vol. 35 (6), pp. 3167-3180. Date of Electronic Publication: 2021 Apr 22.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Experimental/*drug therapy
Memory Disorders/*drug therapy
Spirostans/*pharmacology
Animals ; Cell Line ; Down-Regulation ; Hippocampus/drug effects ; Humans ; Inflammasomes/drug effects ; Male ; Memory/drug effects ; NF-kappa B/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptor, PAR-1/genetics ; Receptor, PAR-1/metabolism ; Signal Transduction/drug effects ; Streptozocin
Czasopismo naukowe
Tytuł :
Extracts from Chinese herbs with anti-amyloid and neuroprotective activities.
Autorzy :
Bednarikova Z; Department of Biophysics, Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Košice, Slovakia.
Gancar M; Department of Biophysics, Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Košice, Slovakia.
Wang R; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Rd., 200237 Shanghai, China.
Zheng L; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Rd., 200237 Shanghai, China.
Tang Y; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Rd., 200237 Shanghai, China.
Luo Y; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Rd., 200237 Shanghai, China.
Huang Y; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Rd., 200237 Shanghai, China.
Spodniakova B; Department of Biophysics, Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Košice, Slovakia.
Ma L; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Rd., 200237 Shanghai, China.
Gazova Z; Department of Biophysics, Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Košice, Slovakia. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 May 15; Vol. 179, pp. 475-484. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article
MeSH Terms :
Abietanes/*pharmacology
Amyloid beta-Peptides/*metabolism
Benzofurans/*pharmacology
Neuroprotective Agents/*pharmacology
Peptide Fragments/*metabolism
Spirostans/*pharmacology
Alzheimer Disease/drug therapy ; Anemarrhena/chemistry ; Cell Line ; China ; Humans ; Plant Extracts ; Salvia miltiorrhiza/chemistry
Czasopismo naukowe
Tytuł :
Effects of Shengmai San on key enzymes involved in hepatic and intestinal drug metabolism in rats.
Autorzy :
Chiang TY; Division of Basic Chinese Medicine, National Research Institute of Chinese Medicine, Taipei, Taiwan; Institute of Biopharmaceutical Sciences, School of Pharmacy, National Yang-Ming University, Taipei, Taiwan.
Wang HJ; School of Pharmacy, National Defense Medical Center, Taipei, Taiwan.
Wang YC; Division of Basic Chinese Medicine, National Research Institute of Chinese Medicine, Taipei, Taiwan.
Chia-Hui Tan E; Division of Clinical Chinese Medicine, National Research Institute of Chinese Medicine, Taipei, Taiwan.
Lee IJ; Department of Herbal Medicine, Yokohama University of Pharmacy, Yokohama, Japan.
Yun CH; School of Biological Sciences and Technology, Chonnam National University, Gwangju, South Korea.
Ueng YF; Division of Basic Chinese Medicine, National Research Institute of Chinese Medicine, Taipei, Taiwan; Institute of Biopharmaceutical Sciences, School of Pharmacy, National Yang-Ming University, Taipei, Taiwan; Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan; Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 May 10; Vol. 271, pp. 113914. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochrome P-450 CYP3A Inhibitors/*pharmacology
Drugs, Chinese Herbal/*pharmacology
Intestines/*enzymology
Liver/*enzymology
Animals ; Biomarkers/blood ; Cyclooctanes/analysis ; Cytochrome P-450 CYP3A/metabolism ; Cytochrome P-450 CYP3A Inhibitors/analysis ; Cytochrome P-450 CYP3A Inhibitors/therapeutic use ; Drug Combinations ; Drugs, Chinese Herbal/analysis ; Drugs, Chinese Herbal/therapeutic use ; Ginsenosides/analysis ; Glucuronosyltransferase/metabolism ; Glutathione Transferase/metabolism ; Herb-Drug Interactions ; Intestines/drug effects ; Lignans/analysis ; Liver/drug effects ; Male ; Microsomes/drug effects ; Microsomes/enzymology ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; Nifedipine/metabolism ; Oxidation-Reduction/drug effects ; Polycyclic Compounds/analysis ; Rats, Sprague-Dawley ; Saponins/chemistry ; Spirostans/chemistry
Czasopismo naukowe
Tytuł :
Potent therapeutic effects of ruscogenin on gastric ulcer established by acetic acid.
Autorzy :
Ercan G; Department of General Surgery, University of Health Science Bagcilar Training and Research Hospital, Istanbul, Turkey. Electronic address: .
Ilbar Tartar R; Department of General Surgery, University of Health Science Bagcilar Training and Research Hospital, Istanbul, Turkey.
Solmaz A; Department of General Surgery, University of Health Science Bagcilar Training and Research Hospital, Istanbul, Turkey.
Gulcicek OB; Department of General Surgery, University of Health Science Bagcilar Training and Research Hospital, Istanbul, Turkey.
Karagulle OO; Department of General Surgery, Ergani State Hospital, Diyarbakır, Turkey.
Meric S; Department of General Surgery, University of Health Science Bagcilar Training and Research Hospital, Istanbul, Turkey.
Cayoren H; Department of General Surgery, University of Health Science Bagcilar Training and Research Hospital, Istanbul, Turkey.
Kusaslan R; Department of General Surgery, University of Health Science Bagcilar Training and Research Hospital, Istanbul, Turkey.
Kemik A; Department of Biochemistry Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Gokceoglu Kayali D; Department of Histology and Embryology, Faculty of Medicine, Marmara University, Istanbul, Turkey.
Cetinel S; Department of Histology and Embryology, Faculty of Medicine, Marmara University, Istanbul, Turkey.
Celik A; Department of General Surgery, University of Health Science Bagcilar Training and Research Hospital, Istanbul, Turkey.
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Źródło :
Asian journal of surgery [Asian J Surg] 2020 Feb; Vol. 43 (2), pp. 405-416. Date of Electronic Publication: 2019 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Phytotherapy*
Spirostans/*administration & dosage
Stomach Ulcer/*drug therapy
Animals ; Chronic Disease ; Collagen/metabolism ; Cytokines/metabolism ; Dinoprostone/metabolism ; Disease Models, Animal ; Epidermal Growth Factor/metabolism ; Female ; Microscopy, Electron, Transmission ; Ophiopogon/chemistry ; Parietal Cells, Gastric/pathology ; Parietal Cells, Gastric/ultrastructure ; Peroxidases/metabolism ; Rats, Sprague-Dawley ; Spirostans/isolation & purification ; Stomach Ulcer/metabolism ; Stomach Ulcer/pathology ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe

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