Temat: "Spirostans" - OpacWWW

Skocz do pozycji: 21.

Tytuł:: Ophiopogonin B induces reactive oxygen species‑dependent apoptosis through the Hippo pathway in nasopharyngeal carcinoma.
Autorzy:: Dong W; Department of Otorhinolaryngology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.
Dong Q; Department of Operating Room, Weifang Yidu Central Hospital, Weifang, Shandong 262500, P.R. China.
Ding H; Department of Emergency, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2021 Jul; Vol. 24 (1). Date of Electronic Publication: 2021 Jun 03.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis/*drug effects
Nasopharyngeal Carcinoma/*metabolism
Nasopharyngeal Neoplasms/*metabolism
Protein Serine-Threonine Kinases/*metabolism
Reactive Oxygen Species/*metabolism
Saponins/*pharmacology
Spirostans/*pharmacology
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Hippo Signaling Pathway ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Nasopharyngeal Neoplasms/pathology ; Signal Transduction/drug effects

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Skocz do pozycji: 22.

Tytuł:: Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway.
Autorzy:: Cao G; Jiangsu Key Laboratory of Traditional Chinese Medicine Evaluation and Translational Research, Department of Complex Prescription of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China. .
Jiang N; Jiangsu Key Laboratory of Traditional Chinese Medicine Evaluation and Translational Research, Department of Complex Prescription of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China. .
Hu Y; Jiangsu Key Laboratory of Traditional Chinese Medicine Evaluation and Translational Research, Department of Complex Prescription of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China. .
Zhang Y; Jiangsu Key Laboratory of Traditional Chinese Medicine Evaluation and Translational Research, Department of Complex Prescription of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China. .
Wang G; Jiangsu Key Laboratory of Traditional Chinese Medicine Evaluation and Translational Research, Department of Complex Prescription of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China. .
Yin M; Jiangsu Key Laboratory of Traditional Chinese Medicine Evaluation and Translational Research, Department of Complex Prescription of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China. .
Ma X; Cellular and Molecular Biology Center, China Pharmaceutical University, Nanjing 211198, China. .
Zhou K; Jiangsu Key Laboratory of Traditional Chinese Medicine Evaluation and Translational Research, Department of Complex Prescription of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China. yuefei_.
Qi J; Jiangsu Key Laboratory of Traditional Chinese Medicine Evaluation and Translational Research, Department of Complex Prescription of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China. .
Yu B; Jiangsu Key Laboratory of Traditional Chinese Medicine Evaluation and Translational Research, Department of Complex Prescription of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China. .
Kou J; Jiangsu Key Laboratory of Traditional Chinese Medicine Evaluation and Translational Research, Department of Complex Prescription of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2016 Aug 29; Vol. 17 (9). Date of Electronic Publication: 2016 Aug 29.
Typ publikacji:: Journal Article
MeSH Terms:: MAP Kinase Signaling System*
Anti-Inflammatory Agents/*pharmacology
Antioxidants/*pharmacology
Blood-Brain Barrier/*drug effects
Infarction, Middle Cerebral Artery/*drug therapy
Inflammasomes/*metabolism
Spirostans/*pharmacology
Animals ; Anti-Inflammatory Agents/therapeutic use ; Antioxidants/therapeutic use ; Blood-Brain Barrier/metabolism ; Carrier Proteins/metabolism ; Caspase 1/genetics ; Caspase 1/metabolism ; Cell Hypoxia ; Cell Line ; Infarction, Middle Cerebral Artery/metabolism ; Inflammasomes/drug effects ; Interleukin-1beta/genetics ; Interleukin-1beta/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Ophiopogon/chemistry ; Reactive Oxygen Species/metabolism ; Spirostans/therapeutic use ; Thioredoxins/metabolism ; Tight Junctions/drug effects ; Tight Junctions/metabolism

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Skocz do pozycji: 23.

Tytuł:: Antiproliferative and anti-inflammatory polyhydroxylated spirostanol saponins from Tupistra chinensis.
Autorzy:: Xiang L; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Yi X; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Wang Y; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
He X; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2016 Aug 17; Vol. 6, pp. 31633. Date of Electronic Publication: 2016 Aug 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Anti-Inflammatory Agents/*pharmacology
Antineoplastic Agents, Phytogenic/*pharmacology
Asparagaceae/*chemistry
Saponins/*pharmacology
Spirostans/*pharmacology
Anti-Inflammatory Agents/isolation & purification ; Antineoplastic Agents, Phytogenic/isolation & purification ; Cell Line, Tumor ; Cell Proliferation/drug effects ; China ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/pharmacology ; Hep G2 Cells ; Humans ; K562 Cells ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Nitric Oxide/biosynthesis ; Plants, Medicinal/chemistry ; Rhizome/chemistry ; Saponins/isolation & purification ; Spirostans/isolation & purification

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Skocz do pozycji: 24.

Tytuł:: In vitro study on the effect of ophiopogonin D on the activity of cytochrome P450 enzymes.
Autorzy:: Ji X; Department of Pediatrics, Weifang Yidu Central Hospital, Weifang, China.
Ding B; Department of Pediatrics, Weifang Yidu Central Hospital, Weifang, China.
Wu X; Department of Pediatrics, Weifang Yidu Central Hospital, Weifang, China.
Liu F; Qingzhou Dongxia Central Health Center, Weifang, China.
Yang F; Department of Pediatrics, Qujing First People's Hospital at Kunming Medical University, Qujing, China.; Pokaż więcej
Źródło:: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Mar; Vol. 51 (3), pp. 262-267. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji:: Journal Article
MeSH Terms:: Cytochrome P-450 Enzyme Inhibitors/*pharmacology
Microsomes, Liver/*drug effects
Saponins/*pharmacology
Spirostans/*pharmacology
Cytochrome P-450 Enzyme System ; Humans ; Microsomes, Liver/enzymology

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Skocz do pozycji: 25.

Tytuł:: Furostanol and Spirostanol Saponins from Tribulus terrestris.
Autorzy:: Wang ZF; Department of Pharmaceutical Care, PLA General Hospital, Beijing 100850, China. .; Tianjin Zhongyi Pharmaceutical Co. Ltd., Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. .
Wang BB; Department of Biology, Beijing Institute of Radiation Medicine, Beijing 100850, China. .
Zhao Y; Department of Biology, Beijing Institute of Radiation Medicine, Beijing 100850, China. .
Wang FX; Department of Biology, Beijing Institute of Radiation Medicine, Beijing 100850, China. .
Sun Y; Department of Pharmaceutical Care, PLA General Hospital, Beijing 100850, China. .
Guo RJ; Department of Pharmaceutical Care, PLA General Hospital, Beijing 100850, China. .
Song XB; Tianjin Zhongyi Pharmaceutical Co. Ltd., Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. .
Xin HL; Department of Pharmaceutical Care, PLA General Hospital, Beijing 100850, China. .
Sun XG; Department of Biology, Beijing Institute of Radiation Medicine, Beijing 100850, China. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2016 Mar 30; Vol. 21 (4), pp. 429. Date of Electronic Publication: 2016 Mar 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Plant Extracts/*chemistry
Saponins/*chemistry
Spirostans/*chemistry
Sterols/*chemistry
Tribulus/*chemistry
Drugs, Chinese Herbal/chemistry ; Molecular Structure ; Saponins/isolation & purification ; Spirostans/isolation & purification ; Sterols/isolation & purification

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Skocz do pozycji: 26.

Tytuł:: Rapid Detection and Characterization of Steroidal Saponins in the Root of Asparagus cochinchinensis by High-Performance Liquid Chromatography Coupled to Electrospray Ionization and Quadrupole Time-of-Flight Mass Spectrometry.
Autorzy:: Ling Y; Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.
He X; Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.
Jiang R; Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.
Zhang Q; Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.
Yuan S; Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.
Liang Y; Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.
Li C; Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.
Zhao Y; Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.
Zhang Q; Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.
Liu K; Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.; Pokaż więcej
Źródło:: Journal of chromatographic science [J Chromatogr Sci] 2020 Apr 25; Vol. 58 (5), pp. 454-463.
Typ publikacji:: Journal Article
MeSH Terms:: Asparagus Plant/*chemistry
Chromatography, High Pressure Liquid/*methods
Saponins/*analysis
Drugs, Chinese Herbal/chemistry ; Glycosides/analysis ; Glycosides/chemistry ; Plant Roots/chemistry ; Pregnanes/analysis ; Pregnanes/chemistry ; Saponins/chemistry ; Spectrometry, Mass, Electrospray Ionization/methods ; Spirostans/analysis ; Spirostans/chemistry ; Steroids/analysis ; Steroids/chemistry ; Sterols/analysis ; Sterols/chemistry ; Tandem Mass Spectrometry/methods

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Skocz do pozycji: 27.

Tytuł:: Synthesis of Thiol Derivatives of Biological Active Compounds for Nanotechnology Application.
Autorzy:: Sidoryk K; Department of Biomedical Technology, Cosmetic Chemicals and Electrochemistry, Team of Chemistry, Łukasiewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland.
Michalak O; Department of Biomedical Technology, Cosmetic Chemicals and Electrochemistry, Team of Chemistry, Łukasiewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland.
Kubiszewski M; Analytical Department, Łukasiewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland.
Leś A; Faculty of Chemistry, University of Warsaw, 1 Pasteur Str., 02-093 Warsaw, Poland.
Cybulski M; Department of Biomedical Technology, Cosmetic Chemicals and Electrochemistry, Team of Chemistry, Łukasiewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland.
Stolarczyk EU; Analytical Department, Łukasiewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland.
Doubsky J; Zentiva k.s., U Kabelovny 130, 102 37 Prague 10, Czech Republic.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2020 Jul 30; Vol. 25 (15). Date of Electronic Publication: 2020 Jul 30.
Typ publikacji:: Journal Article
MeSH Terms:: Capecitabine/*chemistry
Diosgenin/*chemistry
Genistein/*chemistry
Nanotechnology/*methods
Phytochemicals/*chemistry
Spirostans/*chemistry
Sulfhydryl Compounds/*chemical synthesis
Sulfhydryl Compounds/chemistry

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Skocz do pozycji: 28.

Tytuł:: Ophiopogonin D promotes bone regeneration by stimulating CD31 vessel formation.
Autorzy:: Yang M; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China.
Li CJ; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China.
Xiao Y; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China.
Guo Q; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China.
Huang Y; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China.
Su T; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China.
Luo XH; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China.
Jiang TJ; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China.; Pokaż więcej
Źródło:: Cell proliferation [Cell Prolif] 2020 Mar; Vol. 53 (3), pp. e12784. Date of Electronic Publication: 2020 Feb 20.
Typ publikacji:: Journal Article
MeSH Terms:: Bone Regeneration/*drug effects
Neovascularization, Physiologic/*drug effects
Platelet Endothelial Cell Adhesion Molecule-1/*metabolism
Saponins/*pharmacology
Sialoglycoproteins/*metabolism
Spirostans/*pharmacology
Animals ; Cells, Cultured ; Kruppel-Like Transcription Factors/antagonists & inhibitors ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Osteogenesis/drug effects

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Skocz do pozycji: 29.

Tytuł:: Novel steroidal components from the underground parts of Ruscus aculeatus L.
Autorzy:: De Marino S; Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Via D. Montesano 49, I-80131 Napoli, Italy. />Festa C
Zollo F
Iorizzi M; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2012 Nov 26; Vol. 17 (12), pp. 14002-14. Date of Electronic Publication: 2012 Nov 26.
Typ publikacji:: Journal Article
MeSH Terms:: Saponins*/chemistry
Saponins*/isolation & purification
Spirostans*/chemistry
Spirostans*/isolation & purification
Steroids*/chemistry
Steroids*/isolation & purification
Sterols*/chemistry
Sterols*/isolation & purification
Magnetic Resonance Spectroscopy ; Molecular Structure ; Plant Roots/chemistry ; Ruscus/chemistry

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Skocz do pozycji: 30.

Tytuł:: Determination of ruscogenin in crude Chinese medicines and biological samples by immunoassay.
Autorzy:: Liu N; Department of Complex Prescription of TCM, China Pharmaceutical University, 1 Shennong Road, Nanjing, 210038, People's Republic of China.
Wen X
Liu J
Liang M
Zeng H
Lin Y
Yu B; Pokaż więcej
Źródło:: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2006 Nov; Vol. 386 (6), pp. 1727-33. Date of Electronic Publication: 2006 Sep 07.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Medicine, Chinese Traditional*
Enzyme-Linked Immunosorbent Assay/*methods
Ophiopogon/*chemistry
Ophiopogon/*immunology
Spirostans/*analysis
Spirostans/*immunology
Animals ; Antibodies/blood ; Antibodies/immunology ; Antigens/immunology ; Chromatography, High Pressure Liquid ; Female ; Male ; Molecular Structure ; Plant Extracts/chemistry ; Plant Extracts/immunology ; Rabbits ; Rats ; Sensitivity and Specificity ; Spirostans/chemistry ; Spirostans/pharmacokinetics

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Skocz do pozycji: 31.

Tytuł:: Pennogenin tetraglycoside induces rat myometrial contraction and MLC20 phosphorylation via PLC-IP(3) and RhoA/Rho kinase signaling pathways.
Autorzy:: Wang L; Department of Pathophysiology, Beijing Institute of Radiation Medicine, Beijing, China.
Jia C
Yu Z
Liu X
Kang L
Cong Y
Shan Y
Zhao Z
Ma B
Cong Y; Pokaż więcej
Źródło:: PloS one [PLoS One] 2012; Vol. 7 (12), pp. e51536. Date of Electronic Publication: 2012 Dec 12.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Inositol 1,4,5-Trisphosphate/*metabolism
Myosin Light Chains/*metabolism
Spirostans/*pharmacology
Type C Phospholipases/*metabolism
Uterine Contraction/*drug effects
rho-Associated Kinases/*metabolism
rhoA GTP-Binding Protein/*metabolism
Animals ; Calcium/metabolism ; Calmodulin/metabolism ; Dose-Response Relationship, Drug ; Female ; In Vitro Techniques ; Myosin-Light-Chain Kinase/antagonists & inhibitors ; Myosin-Light-Chain Kinase/metabolism ; Phosphorylation/drug effects ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Spirostans/chemistry ; Time Factors

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Skocz do pozycji: 32.

Tytuł:: Two new steroidal saponins from Tribulus terrestris L.
Autorzy:: Liu T; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Lu X
Wu B
Chen G
Hua HM
Pei YH; Pokaż więcej
Źródło:: Journal of Asian natural products research [J Asian Nat Prod Res] 2010 Jan; Vol. 12 (1), pp. 30-5.
Typ publikacji:: Journal Article
MeSH Terms:: Drugs, Chinese Herbal/*isolation & purification
Saponins/*isolation & purification
Spirostans/*isolation & purification
Tribulus/*chemistry
Drugs, Chinese Herbal/chemistry ; Fruit/chemistry ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Saponins/chemistry ; Spirostans/chemistry ; Stereoisomerism

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Skocz do pozycji: 33.

Tytuł:: Two novel furostanol saponins from Ophiopogon japonicus.
Autorzy:: Zhang T; Beijing Institute of Radiation Medicine, China.
Zou P
Kang LP
Yu HS
Liu YX
Song XB
Ma BP; Pokaż więcej
Źródło:: Journal of Asian natural products research [J Asian Nat Prod Res] 2009 Sep; Vol. 11 (9), pp. 824-31.
Typ publikacji:: Journal Article
MeSH Terms:: Drugs, Chinese Herbal/*isolation & purification
Ophiopogon/*chemistry
Saponins/*isolation & purification
Spirostans/*isolation & purification
Drugs, Chinese Herbal/chemistry ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Plant Tubers/chemistry ; Saponins/chemistry ; Spirostans/chemistry ; Stereoisomerism

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Skocz do pozycji: 34.

Tytuł:: Allergic contact dermatitis to ruscogenins.
Autorzy:: Ramírez-Hernández M; Department of Allergy, Virgen de la Arrixaca University Hospital, 30120 El Palmar, Murcia, Spain. />García-Sellés J
Mérida-Fernández C
Martínez-Escribano JA; Pokaż więcej
Źródło:: Contact dermatitis [Contact Dermatitis] 2006 Jan; Vol. 54 (1), pp. 60.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Dermatitis, Allergic Contact/*diagnosis
Spirostans/*adverse effects
Administration, Cutaneous ; Adult ; Dermatitis, Allergic Contact/etiology ; Dermatitis, Allergic Contact/pathology ; Diagnosis, Differential ; Female ; Hemorrhoids/drug therapy ; Humans ; Patch Tests ; Phytotherapy ; Plant Extracts/administration & dosage ; Plant Extracts/adverse effects ; Ruscus/adverse effects ; Spirostans/administration & dosage

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Skocz do pozycji: 35.

Tytuł:: Furostanoside from Asparagus filicinus.
Autorzy:: Li YF; Department of Pharmaceutics and Bioengineering, Sichuan University, Chengdu, China.
Hu LH
Lou FC
Hong JR
Li J
Shen Q; Pokaż więcej
Źródło:: Journal of Asian natural products research [J Asian Nat Prod Res] 2005 Feb; Vol. 7 (1), pp. 43-7.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Asparagus Plant/*chemistry
Saponins/*isolation & purification
Spirostans/*isolation & purification
Magnetic Resonance Spectroscopy ; Molecular Conformation ; Saponins/chemistry ; Spirostans/chemistry

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Skocz do pozycji: 36.

Tytuł:: Two steroidal saponins from Camassia cusickii induce L1210 cell death through the apoptotic mechanism.
Autorzy:: Candra E; Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Sendai, Japan.
Matsunaga K
Fujiwara H
Mimaki Y
Sashida Y
Yamakuni T
Ohizumi Y; Pokaż więcej
Źródło:: Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2001 Nov; Vol. 79 (11), pp. 953-8.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Apoptosis*
Liliaceae*
Saponins/*pharmacology
Spirostans/*pharmacology
Animals ; Blotting, Western ; Cell Separation ; DNA Fragmentation ; Electrophoresis, Agar Gel ; Flow Cytometry ; Leukemia L1210 ; Mice ; Plant Structures ; Saponins/isolation & purification ; Spirostans/isolation & purification ; Tumor Cells, Cultured

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Skocz do pozycji: 37.

Tytuł:: Cardioprotection by combination of three compounds from ShengMai preparations in mice with myocardial ischemia/reperfusion injury through AMPK activation-mediated mitochondrial fission.
Autorzy:: Li F; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, P.R. China.
Fan X; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, P.R. China.
Zhang Y; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, P.R. China.
Pang L; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, P.R. China.
Ma X; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, P.R. China.
Song M; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, P.R. China.
Kou J; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, P.R. China.
Yu B; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, P.R. China.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2016 Nov 21; Vol. 6, pp. 37114. Date of Electronic Publication: 2016 Nov 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: AMP-Activated Protein Kinases/*metabolism
Cardiotonic Agents/*administration & dosage
Drugs, Chinese Herbal/*administration & dosage
Myocardial Reperfusion Injury/*drug therapy
Myocardial Reperfusion Injury/*metabolism
Animals ; Apoptosis/drug effects ; Cyclooctanes/administration & dosage ; Drug Combinations ; Drug Therapy, Combination ; Dynamins/metabolism ; Ginsenosides/administration & dosage ; Lignans/administration & dosage ; Male ; Mice, Inbred ICR ; Mitochondrial Dynamics/drug effects ; Myocardial Reperfusion Injury/pathology ; Polycyclic Compounds/administration & dosage ; Spirostans/administration & dosage

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Skocz do pozycji: 38.

Tytuł:: Effects of ophiopogonin B on the proliferation and apoptosis of SGC‑7901 human gastric cancer cells.
Autorzy:: Zhang W; School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, P.R. China.
Zhang Q; Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, P.R. China.
Jiang Y; Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, P.R. China.
Li F; School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, P.R. China.
Xin H; Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2016 Jun; Vol. 13 (6), pp. 4981-6. Date of Electronic Publication: 2016 Apr 27.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Saponins/*pharmacology
Spirostans/*pharmacology
Biomarkers ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Humans ; Matrix Metalloproteinases/metabolism ; Reactive Oxygen Species/metabolism ; Stomach Neoplasms/metabolism

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Skocz do pozycji: 39.

Tytuł:: Steroidal Saponins from the Rhizomes of Aspidistra typica.
Autorzy:: Cui JM; Beijing Institute of Radiation Medicine, Beijing, 100850, PR China.; School of Pharmaceutical Sciences, Central South University, Changsha, 410013, China.
Kang LP; State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, People's Republic of China.
Zhao Y; Beijing Institute of Radiation Medicine, Beijing, 100850, PR China.
Zhao JY; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
Zhang J; Ovation Health Science and Technology Co. Ltd., ENN Group, Langfang, 065001, China.
Pang X; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
Yu HS; Beijing Institute of Radiation Medicine, Beijing, 100850, PR China.
Jia DX; Ovation Health Science and Technology Co. Ltd., ENN Group, Langfang, 065001, China.
Liu C; Beijing Institute of Radiation Medicine, Beijing, 100850, PR China.
Yu LY; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
Ma BP; Beijing Institute of Radiation Medicine, Beijing, 100850, PR China.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2016 Mar 03; Vol. 11 (3), pp. e0150595. Date of Electronic Publication: 2016 Mar 03 (Print Publication: 2016).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Anti-HIV Agents/*pharmacology
HIV-1/*drug effects
Liliaceae/*chemistry
Reassortant Viruses/*drug effects
Rhizome/*chemistry
Saponins/*pharmacology
Sterols/*pharmacology
Anti-HIV Agents/isolation & purification ; Capsid Proteins/antagonists & inhibitors ; Capsid Proteins/genetics ; Capsid Proteins/metabolism ; Gene Expression ; Genes, Reporter ; HEK293 Cells ; HIV-1/genetics ; HIV-1/growth & development ; Humans ; Luciferases/antagonists & inhibitors ; Luciferases/genetics ; Luciferases/metabolism ; Magnetic Resonance Spectroscopy ; Plant Extracts/chemistry ; Reassortant Viruses/genetics ; Reassortant Viruses/growth & development ; Saponins/isolation & purification ; Spirostans/isolation & purification ; Spirostans/pharmacology ; Steroids/isolation & purification ; Steroids/pharmacology ; Sterols/isolation & purification ; Structure-Activity Relationship ; Vesiculovirus/genetics ; Virus Replication/drug effects

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Skocz do pozycji: 40.

Tytuł:: Discovery of Anti-inflammatory Ingredients in Chinese Herbal Formula Kouyanqing Granule based on Relevance Analysis between Chemical Characters and Biological Effects.
Autorzy:: Liu H; Guangzhou Quality R&D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, P.R. China.
Zheng YF; Guangzhou Quality R&D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, P.R. China.
Li CY; Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co., Ltd., Guangzhou, P.R. China.
Zheng YY; Guangzhou Quality R&D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, P.R. China.
Wang DQ; Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co., Ltd., Guangzhou, P.R. China.
Wu Z; Guangzhou Quality R&D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, P.R. China.
Huang L; Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co., Ltd., Guangzhou, P.R. China.
Wang YG; Guangzhou Quality R&D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, P.R. China.
Li PB; Guangzhou Quality R&D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, P.R. China.
Peng W; Guangzhou Quality R&D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, P.R. China.
Su WW; Guangzhou Quality R&D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, P.R. China.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2015 Dec 10; Vol. 5, pp. 18080. Date of Electronic Publication: 2015 Dec 10.
Typ publikacji:: Journal Article
MeSH Terms:: Anti-Inflammatory Agents/*pharmacology
Drug Discovery/*methods
Drugs, Chinese Herbal/*chemistry
Keratinocytes/*drug effects
Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/isolation & purification ; Cells, Cultured ; Chlorogenic Acid/analogs & derivatives ; Chlorogenic Acid/chemistry ; Chlorogenic Acid/isolation & purification ; Chlorogenic Acid/pharmacology ; Chromatography, Liquid/methods ; Cinnamates/chemistry ; Cinnamates/isolation & purification ; Cinnamates/pharmacology ; Flavones/chemistry ; Flavones/isolation & purification ; Flavones/pharmacology ; Glucosides/chemistry ; Glucosides/isolation & purification ; Glucosides/pharmacology ; Humans ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Interleukin-8/metabolism ; Keratinocytes/cytology ; Keratinocytes/metabolism ; Molecular Structure ; Smoke ; Spirostans/chemistry ; Spirostans/isolation & purification ; Spirostans/pharmacology ; Tandem Mass Spectrometry/methods ; Tobacco Products ; Tumor Necrosis Factor-alpha/metabolism

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