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Tytuł:
Increased number of T cells and exacerbated inflammatory pathophysiology in a human IgG4 knock-in MRL/lpr mouse model.
Autorzy:
Gon Y; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Clinical Immunology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Kandou T; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Tsuruyama T; Department of Drug Discovery Medicine, Pathology Division, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Iwasaki T; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kitagori K; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Murakami K; Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Nakashima R; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Akizuki S; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Morinobu A; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hikida M; Faculty of Engineering Science, Graduate School of Engineering Science, Akita University, Akita, Japan.
Mimori T; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Ijinkai Takeda General Hospital, Kyoto, Japan.
Yoshifuji H; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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Źródło:
PloS one [PLoS One] 2023 Feb 10; Vol. 18 (2), pp. e0279389. Date of Electronic Publication: 2023 Feb 10 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
T-Lymphocytes*
Immunoglobulin G4-Related Disease*
Humans ; Mice ; Animals ; Immunoglobulin G ; Mice, Inbred MRL lpr ; Mice, Inbred C57BL ; Spleen
Czasopismo naukowe
Tytuł:
Inflammation in an Animal Model of Multiple Sclerosis Leads to MicroRNA-25-3p Dysregulation Associated with Inhibition of Pten and Klf4.
Autorzy:
Zare-Chahoki A; Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran AND Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. .
Ahmadi-Zeidabadi M; Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. .
Azadarmaki S; Clinical Laboratory, Khatam Alanbia Hospital, Tehran, Iran. .
Ghorbani S; Hotchkiss Brain Institute and the Department of Clinical Neuroscience, University of Calgary, Calgary, Canada. .
Noorbakhsh F; Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran AND Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. .
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Źródło:
Iranian journal of allergy, asthma, and immunology [Iran J Allergy Asthma Immunol] 2021 Jun 06; Vol. 20 (3), pp. 314-325. Date of Electronic Publication: 2021 Jun 06.
Typ publikacji:
Journal Article
MeSH Terms:
Cytokines/*metabolism
Encephalomyelitis, Autoimmune, Experimental/*enzymology
Inflammation Mediators/*metabolism
Macrophages/*enzymology
MicroRNAs/*metabolism
PTEN Phosphohydrolase/*metabolism
Spleen/*enzymology
T-Lymphocytes/*enzymology
Animals ; Autoimmunity ; Cells, Cultured ; Cytokines/genetics ; Encephalomyelitis, Autoimmune, Experimental/chemically induced ; Encephalomyelitis, Autoimmune, Experimental/genetics ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Female ; Freund's Adjuvant ; Gene Expression Regulation ; Kruppel-Like Factor 4/genetics ; Kruppel-Like Factor 4/metabolism ; Macrophage Activation ; Macrophages/immunology ; Mice, Inbred C57BL ; MicroRNAs/genetics ; Myelin-Oligodendrocyte Glycoprotein ; PTEN Phosphohydrolase/genetics ; Peptide Fragments ; Signal Transduction ; Spleen/immunology ; T-Lymphocytes/immunology ; Mice
Czasopismo naukowe
Tytuł:
miR-155 influences cell-mediated immunity in Balb/c mice treated with aflatoxin M 1 .
Autorzy:
Shirani K; Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Riahi Zanjani B; Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mehri S; Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.; Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran.
Razavi-Azarkhiavi K; Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Badiee A; Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Hayes AW; University of South Florida College of Public Health, Tampa, FL, USA.; Michigan State University, East Lansing, MI, USA.
Giesy JP; Department of Veterinary Biomedical Sciences and Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.; Department of Zoology and Center for Integrative Toxicology, Michigan State University, East Lansing, MI, USA.; School of Biological Sciences, University of Hong Kong, Hong Kong, SAR, China.
Karimi G; Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.; Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran.
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Źródło:
Drug and chemical toxicology [Drug Chem Toxicol] 2021 Jan; Vol. 44 (1), pp. 39-46. Date of Electronic Publication: 2019 Feb 11.
Typ publikacji:
Journal Article
MeSH Terms:
Aflatoxin M1/*toxicity
Immunity, Cellular/*drug effects
MicroRNAs/*metabolism
Spleen/*drug effects
T-Lymphocytes/*drug effects
Aflatoxin M1/administration & dosage ; Animals ; Cell Proliferation/drug effects ; Cytokines/metabolism ; Gene Expression Regulation ; Injections, Intraperitoneal ; Lymphocyte Activation/drug effects ; Male ; Mice, Inbred BALB C ; MicroRNAs/genetics ; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases/metabolism ; Signal Transduction ; Spleen/immunology ; Spleen/metabolism ; Suppressor of Cytokine Signaling 1 Protein/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł:
A MLR-Based Approach to Analyze Regulators of T Lymphocyte Activation In Vivo.
Autorzy:
Koutník J; Institute of Cell Genetics, Medical University Innsbruck, 6020 Innsbruck, Austria.
Klepsch V; Institute of Cell Genetics, Medical University Innsbruck, 6020 Innsbruck, Austria.
Pommermayr M; Institute of Cell Genetics, Medical University Innsbruck, 6020 Innsbruck, Austria.
Thuille N; Institute of Cell Genetics, Medical University Innsbruck, 6020 Innsbruck, Austria.
Baier G; Institute of Cell Genetics, Medical University Innsbruck, 6020 Innsbruck, Austria.
Siegmund K; Institute of Cell Genetics, Medical University Innsbruck, 6020 Innsbruck, Austria.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 May 10; Vol. 23 (10). Date of Electronic Publication: 2022 May 10.
Typ publikacji:
Journal Article
MeSH Terms:
Lymphocyte Activation*
T-Lymphocytes*
Animals ; Lymphocyte Culture Test, Mixed ; Mice ; Spleen
Czasopismo naukowe
Tytuł:
CAR T cells produced in vivo to treat cardiac injury.
Autorzy:
Rurik JG; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Tombácz I; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Yadegari A; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Méndez Fernández PO; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Shewale SV; Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Li L; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Kimura T; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Soliman OY; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Papp TE; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Tam YK; Acuitas Therapeutics, Vancouver, British Columbia V6T 1Z3, Canada.
Mui BL; Acuitas Therapeutics, Vancouver, British Columbia V6T 1Z3, Canada.
Albelda SM; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Puré E; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
June CH; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Aghajanian H; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Weissman D; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Parhiz H; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Epstein JA; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Jan 07; Vol. 375 (6576), pp. 91-96. Date of Electronic Publication: 2022 Jan 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cell Engineering*
Immunotherapy, Adoptive*
Liposomes*
Nanoparticles*
Endopeptidases/*immunology
Heart Diseases/*therapy
Membrane Proteins/*immunology
Receptors, Chimeric Antigen/*immunology
T-Lymphocytes/*immunology
Adoptive Transfer ; Animals ; CD5 Antigens/immunology ; Endopeptidases/metabolism ; Fibroblasts/immunology ; Fibroblasts/pathology ; Fibrosis/therapy ; HEK293 Cells ; Heart Diseases/pathology ; Heart Failure/therapy ; Humans ; Male ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Myocardium/pathology ; RNA, Messenger/genetics ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/metabolism ; Spleen/immunology ; Trogocytosis
Czasopismo naukowe
Tytuł:
Nanovesicles released by OKT3 hybridoma express fully active antibodies.
Autorzy:
Logozzi M; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Di Raimo R; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Properzi F; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.
Barca S; FARVA - National Centre for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy.
Angelini DF; Neuroimmunology Unit, IRCCS Santa Lucia Foundation, Rome, Italy.
Mizzoni D; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Falchi M; National AIDS Center, Istituto Superiore di Sanità, Rome, Italy.
Battistini L; Neuroimmunology Unit, IRCCS Santa Lucia Foundation, Rome, Italy.
Fais S; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 175-182.
Typ publikacji:
Journal Article
MeSH Terms:
B-Lymphocytes/*immunology
Exosomes/*immunology
Hybridomas/*immunology
Immunoglobulin G/*biosynthesis
Muromonab-CD3/*immunology
T-Lymphocytes/*immunology
Animals ; Antigens, Surface/genetics ; Antigens, Surface/immunology ; B-Lymphocytes/cytology ; CD3 Complex/genetics ; CD3 Complex/immunology ; Cell Line, Tumor ; Cytokines/biosynthesis ; Cytokines/immunology ; Exosomes/chemistry ; Exosomes/genetics ; Gene Expression ; Humans ; Hybridomas/chemistry ; Immunoglobulin G/immunology ; Lymphocyte Activation ; Macrophages/cytology ; Macrophages/immunology ; Mice ; Multiple Myeloma/immunology ; Muromonab-CD3/genetics ; Neoplasms, Experimental/immunology ; Primary Cell Culture ; Spleen/cytology ; Spleen/immunology ; T-Lymphocytes/cytology
Czasopismo naukowe
Tytuł:
T Cell Interactions in Mycobacterial Granulomas: Non-Specific T Cells Regulate Mycobacteria-Specific T Cells in Granulomatous Lesions.
Autorzy:
Co DO; Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Hogan LH; The Institute for Clinical and Translational Research, University of Wisconsin-Madison, Madison, WI 53705, USA.
Karman J; Cambridge Research Center, Abbvie, Inc., Cambridge, MA 02139, USA.
Herbath M; Department of Pathology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Fabry Z; Department of Pathology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Sandor M; Department of Pathology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
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Źródło:
Cells [Cells] 2021 Nov 24; Vol. 10 (12). Date of Electronic Publication: 2021 Nov 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cell Communication*
Granuloma/*immunology
Granuloma/*microbiology
Mycobacterium/*physiology
T-Lymphocytes/*immunology
Animals ; Antigens, Bacterial/immunology ; Conalbumin ; Cytochromes c/metabolism ; Cytokines/metabolism ; Immunization ; Lymphocyte Activation/immunology ; Macrophage Activation ; Mice, Transgenic ; Models, Biological ; Mycobacterium bovis/physiology ; Spleen/cytology ; Up-Regulation
Czasopismo naukowe
Tytuł:
Salt inducible kinases 2 and 3 are required for thymic T cell development.
Autorzy:
Nefla M; Division of Cell Signalling and Immunology, Wellcome Trust Building, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.
Darling NJ; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.
van Gijsel Bonnello M; Division of Cell Signalling and Immunology, Wellcome Trust Building, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.
Cohen P; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.
Arthur JSC; Division of Cell Signalling and Immunology, Wellcome Trust Building, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK. .
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Źródło:
Scientific reports [Sci Rep] 2021 Nov 03; Vol. 11 (1), pp. 21550. Date of Electronic Publication: 2021 Nov 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Serine-Threonine Kinases/*genetics
T-Lymphocytes/*cytology
Alleles ; Animals ; Apoptosis ; CD4-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/cytology ; Cell Differentiation ; Cell Proliferation ; Cell Separation ; Exons ; Female ; Flow Cytometry ; Immunity, Innate ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphorylation ; Protein Isoforms ; Signal Transduction/physiology ; Spleen/metabolism ; Thymocytes/cytology ; Transgenes
Czasopismo naukowe
Tytuł:
Neutrophil-suppressive activity over T-cell proliferation and fungal clearance in a murine model of Fonsecaea pedrosoi infection.
Autorzy:
Breda LCD; Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Av Prof. Lineu Prestes, 580, São Paulo, SP, 05508-000, Brazil.; Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.
de Souza Breda CN; Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.
Kaihami GH; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
de Almeida JRF; Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Av Prof. Lineu Prestes, 580, São Paulo, SP, 05508-000, Brazil.
Jannuzzi GP; Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Av Prof. Lineu Prestes, 580, São Paulo, SP, 05508-000, Brazil.
Ferreira LG; Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Av Prof. Lineu Prestes, 580, São Paulo, SP, 05508-000, Brazil.
de Almeida SR; Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Av Prof. Lineu Prestes, 580, São Paulo, SP, 05508-000, Brazil. .
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Źródło:
Scientific reports [Sci Rep] 2021 Oct 12; Vol. 11 (1), pp. 20220. Date of Electronic Publication: 2021 Oct 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies/*adverse effects
Antigens, Ly/*immunology
Chromoblastomycosis/*immunology
Fonsecaea/*pathogenicity
Neutropenia/*immunology
Neutrophils/*metabolism
T-Lymphocytes/*metabolism
Animals ; Cell Polarity ; Cell Proliferation ; Chromoblastomycosis/complications ; Disease Models, Animal ; Fonsecaea/immunology ; Humans ; Interleukin-6/metabolism ; Liver/immunology ; Lymphocyte Activation ; Mice ; Neutropenia/chemically induced ; Spleen/immunology
SCR Organism:
Fonsecaea pedrosoi
Czasopismo naukowe
Tytuł:
Restored immune cell functions upon clearance of senescence in the irradiated splenic environment.
Autorzy:
Palacio L; Centre de recherche du CHU Ste-Justine, Montreal, Quebec, Canada.; Département de pharmacologie et physiologie, Faculté de Médecine, Université de Montréal, Montreal, Quebec, Canada.
Goyer ML; Centre de recherche du CHU Ste-Justine, Montreal, Quebec, Canada.; Département de pharmacologie et physiologie, Faculté de Médecine, Université de Montréal, Montreal, Quebec, Canada.
Maggiorani D; Centre de recherche du CHU Ste-Justine, Montreal, Quebec, Canada.; Département de pharmacologie et physiologie, Faculté de Médecine, Université de Montréal, Montreal, Quebec, Canada.
Espinosa A; Centre de recherche du CHU Ste-Justine, Montreal, Quebec, Canada.
Villeneuve N; Centre de recherche du CHU Ste-Justine, Montreal, Quebec, Canada.
Bourbonnais S; Centre de recherche du CHU Ste-Justine, Montreal, Quebec, Canada.
Moquin-Beaudry G; Centre de recherche du CHU Ste-Justine, Montreal, Quebec, Canada.; Département de pharmacologie et physiologie, Faculté de Médecine, Université de Montréal, Montreal, Quebec, Canada.
Le O; Centre de recherche du CHU Ste-Justine, Montreal, Quebec, Canada.
Demaria M; European Research Institute for the Biology of Aging (ERIBA), University Medical Center Groningen (UMCG), University of Groningen, Groningen, The Netherlands.
Davalos AR; Buck Institute For Research on Aging, Novato, California.
Decaluwe H; Centre de recherche du CHU Ste-Justine, Montreal, Quebec, Canada.; Département de Pédiatrie, Faculté de Médecine, Université de Montréal, Montreal, Quebec, Canada.
Beauséjour C; Centre de recherche du CHU Ste-Justine, Montreal, Quebec, Canada.; Département de pharmacologie et physiologie, Faculté de Médecine, Université de Montréal, Montreal, Quebec, Canada.
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Źródło:
Aging cell [Aging Cell] 2019 Aug; Vol. 18 (4), pp. e12971. Date of Electronic Publication: 2019 May 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Radiation, Ionizing*
Cellular Senescence/*radiation effects
Spleen/*metabolism
Spleen/*radiation effects
T-Lymphocytes/*immunology
T-Lymphocytes/*radiation effects
Animals ; Antiviral Agents/therapeutic use ; Arenaviridae Infections/drug therapy ; Arenaviridae Infections/immunology ; Arenaviridae Infections/virology ; Cell Proliferation/radiation effects ; Cells, Cultured ; Cellular Senescence/genetics ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Ganciclovir/therapeutic use ; Lymphocytic choriomeningitis virus/immunology ; Macrophages/metabolism ; Mice ; Mice, Transgenic ; Phenotype ; Rejuvenation/physiology ; Spleen/virology
Czasopismo naukowe
Tytuł:
Venoarterial Extracorporeal Membrane Oxygenation Increased Immune Function of Spleen and Decreased Reactive Oxygen Species During Post-Resuscitation.
Autorzy:
Zhang Q; Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Liu B; Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Zhao L; Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Lian Y; Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Yuan X; Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Tong-Ren Hospital, Capital Medical University, Beijing, China.
Zhang Y; Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Tong-Ren Hospital, Capital Medical University, Beijing, China.
Lin J; Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Tong-Ren Hospital, Capital Medical University, Beijing, China.
Li C; Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
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Źródło:
Artificial organs [Artif Organs] 2019 Apr; Vol. 43 (4), pp. 377-385. Date of Electronic Publication: 2018 Nov 09.
Typ publikacji:
Journal Article
MeSH Terms:
Cardiopulmonary Resuscitation*/methods
Extracorporeal Membrane Oxygenation*/methods
Spleen/*immunology
T-Lymphocytes/*immunology
Ventricular Fibrillation/*therapy
Animals ; Hemodynamics ; Interleukins/analysis ; Interleukins/immunology ; Male ; Reactive Oxygen Species/analysis ; Reactive Oxygen Species/immunology ; Spleen/cytology ; Spleen/pathology ; Swine ; Swine, Miniature ; T-Lymphocytes/pathology ; Ventricular Fibrillation/immunology ; Ventricular Fibrillation/pathology ; Ventricular Fibrillation/physiopathology
Czasopismo naukowe
Tytuł:
Predicted limited redistribution of T cells to secondary lymphoid tissue correlates with increased risk of haematological malignancies in asplenic patients.
Autorzy:
Kmieciak AE; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Andrew Wiles Building, Woodstock Rd, Oxford, OX2 6GG, UK. .
Brown LV; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Andrew Wiles Building, Woodstock Rd, Oxford, OX2 6GG, UK.
Coles MC; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Dr, Headington, Oxford, OX3 7FY, UK.
Wagg J; AC Immune, EPFL Innovation Park, 1015, Lausanne, Switzerland.
Phipps A; Pharmaceutical Sciences-Clinical Pharmacology Roche Innovation Centre Welwyn 6 Falcon Way, Shire Park, Welwyn Garden City, AL7 1TW, UK.; Clinical Pharmacology and Quantitative Pharmacology-Oncoloy, AstraZeneca, Cambridge, CB2 0AA, UK.
Gaffney EA; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Andrew Wiles Building, Woodstock Rd, Oxford, OX2 6GG, UK.
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Źródło:
Scientific reports [Sci Rep] 2021 Aug 12; Vol. 11 (1), pp. 16394. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hematologic Neoplasms/*immunology
Lymphoid Tissue/*immunology
Splenic Diseases/*immunology
T-Lymphocytes/*immunology
Humans ; Lymphocytes/immunology ; Spleen/immunology ; Splenectomy/methods
Czasopismo naukowe
Tytuł:
High-Affinity Anti-VISTA Antibody Protects against Sepsis by Inhibition of T Lymphocyte Apoptosis and Suppression of the Inflammatory Response.
Autorzy:
Tao T; Department of Anesthesiology, Air Force Medical Center, Beijing 100142, China.; Department of Pain Medicine, Air Force Medical Center, Beijing 100142, China.
Bo L; Faculty of Anesthesiology, Changhai Hospital, Shanghai 200433, China.
Li T; Department of Pathology, Air Force Medical Center, Beijing 100142, China.
Shi L; Department of Pain Medicine, Air Force Medical Center, Beijing 100142, China.
Zhang H; Department of Neurosurgery, Air Force Medical Center, Beijing 100142, China.
Ye B; Department of Anesthesiology, Air Force Medical Center, Beijing 100142, China.
Xu Y; Department of Anesthesiology, Air Force Medical Center, Beijing 100142, China.
Ma Q; Department of Anesthesiology, Air Force Medical Center, Beijing 100142, China.
Deng X; Faculty of Anesthesiology, Changhai Hospital, Shanghai 200433, China.
Zhang G; Department of Pain Medicine, Air Force Medical Center, Beijing 100142, China.
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Źródło:
Mediators of inflammation [Mediators Inflamm] 2021 Jul 28; Vol. 2021, pp. 6650329. Date of Electronic Publication: 2021 Jul 28 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
B7 Antigens/*immunology
Inflammation/*metabolism
Membrane Proteins/*metabolism
Sepsis/*prevention & control
T-Lymphocytes/*pathology
Animals ; CD3 Complex/metabolism ; Cecum ; Cytokines/metabolism ; Disease Models, Animal ; Immune System ; Immunotherapy ; Lymphocyte Activation ; Lymphocyte Count ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Protective Agents/pharmacology ; Sepsis/microbiology ; Spleen/metabolism ; Thymus Gland/metabolism
Czasopismo naukowe
Tytuł:
Generation and first characterization of TRDC-knockout pigs lacking γδ T cells.
Autorzy:
Petersen B; Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut, Hoeltystrasse 10, Neustadt am Rbge./Mariensee, 31535, Neustadt, Germany. .
Kammerer R; Institute of Immunology, Friedrich-Loeffler-Institut, Suedufer 10, Insel Riems, 17493, Greifswald, Germany. .
Frenzel A; Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut, Hoeltystrasse 10, Neustadt am Rbge./Mariensee, 31535, Neustadt, Germany.
Hassel P; Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut, Hoeltystrasse 10, Neustadt am Rbge./Mariensee, 31535, Neustadt, Germany.
Dau TH; Institute of Immunology, Friedrich-Loeffler-Institut, Suedufer 10, Insel Riems, 17493, Greifswald, Germany.
Becker R; Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut, Hoeltystrasse 10, Neustadt am Rbge./Mariensee, 31535, Neustadt, Germany.
Breithaupt A; Department of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Insel Riems, Greifswald, Germany.
Ulrich RG; Institute for Veterinary-Pathology, Leipzig University, Leipzig, Germany.
Lucas-Hahn A; Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut, Hoeltystrasse 10, Neustadt am Rbge./Mariensee, 31535, Neustadt, Germany.
Meyers G; Institute of Immunology, Friedrich-Loeffler-Institut, Suedufer 10, Insel Riems, 17493, Greifswald, Germany.
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Źródło:
Scientific reports [Sci Rep] 2021 Jul 22; Vol. 11 (1), pp. 14965. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Knockout Techniques/*methods
Receptors, Antigen, T-Cell, gamma-delta/*deficiency
T-Lymphocytes/*immunology
Animals ; Antibodies, Neutralizing/blood ; Gene Expression Profiling ; Gene Regulatory Networks ; Leukocytes, Mononuclear/immunology ; Mice ; Nuclear Transfer Techniques ; Spleen/immunology ; Swine ; Exome Sequencing
Czasopismo naukowe
Tytuł:
Methamphetamine facilitates pulmonary and splenic tissue injury and reduces T cell infiltration in C57BL/6 mice after antigenic challenge.
Autorzy:
Hernandez-Santini AC; Department of Biology, University of Puerto Rico-Ponce, Ponce, PR, USA.
Mitha AN; Department of Biomedical Sciences, NYIT College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY, USA.
Chow D; Department of Biological Sciences, The Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX, USA.
Hamed MF; Department of Oral Biology, University of Florida College of Dentistry, 1395 Center Drive, Room DG-48, P.O. Box 100424, Gainesville, FL, 32610, USA.; Department of Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
Gucwa AL; Department of Biology, Farmingdale State College, Farmingdale, NY, USA.
Vaval V; Department of Biomedical Sciences, Long Island University, C. W. Post, Brookville, NY, USA.
Martinez LR; Department of Oral Biology, University of Florida College of Dentistry, 1395 Center Drive, Room DG-48, P.O. Box 100424, Gainesville, FL, 32610, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Apr 15; Vol. 11 (1), pp. 8207. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Lung Injury/*chemically induced
Methamphetamine/*pharmacology
Splenic Diseases/*chemically induced
T-Lymphocytes/*drug effects
Amphetamine-Related Disorders/immunology ; Amphetamine-Related Disorders/pathology ; Animals ; Antigens, Bacterial ; Apoptosis/drug effects ; Chemotaxis, Leukocyte/drug effects ; Chemotaxis, Leukocyte/physiology ; Disease Models, Animal ; Female ; Humans ; Inflammation/chemically induced ; Inflammation/immunology ; Inflammation/pathology ; Jurkat Cells ; Lipopolysaccharides ; Lung/drug effects ; Lung/immunology ; Lung/pathology ; Lung Injury/immunology ; Lung Injury/pathology ; Lymphocyte Activation/drug effects ; Mice ; Mice, Inbred C57BL ; Spleen/drug effects ; Spleen/immunology ; Spleen/injuries ; Spleen/pathology ; Splenic Diseases/immunology ; Splenic Diseases/pathology ; T-Lymphocytes/physiology
Czasopismo naukowe
Tytuł:
Systemic T Cell Exhaustion Dynamics Is Linked to Early High Mobility Group Box Protein 1 (HMGB1) Driven Hyper-Inflammation in a Polytrauma Rat Model.
Autorzy:
Muire PJ; Combat Wound Care, US Army Institute of Surgical Research, JBSA Ft Sam Houston, San Antonio, TX 78234, USA.
Schwacha MG; Division of Trauma and Emergency Surgery, Department of Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Wenke JC; Combat Wound Care, US Army Institute of Surgical Research, JBSA Ft Sam Houston, San Antonio, TX 78234, USA.
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Źródło:
Cells [Cells] 2021 Jun 30; Vol. 10 (7). Date of Electronic Publication: 2021 Jun 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HMGB1 Protein/*metabolism
Inflammation/*immunology
Multiple Trauma/*immunology
T-Lymphocytes/*immunology
Animals ; Antibodies/pharmacology ; Blood Proteins/metabolism ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; Cell Count ; Cell Membrane/metabolism ; Cytokines/blood ; Disease Models, Animal ; Male ; Models, Biological ; Multiple Trauma/blood ; Myeloid Cells/drug effects ; Myeloid Cells/metabolism ; Neutralization Tests ; Osteotomy ; Rats, Sprague-Dawley ; Receptor for Advanced Glycation End Products/metabolism ; Spleen/immunology ; Toll-Like Receptor 4/metabolism ; Rats
Czasopismo naukowe
Tytuł:
Lipofection with Synthetic mRNA as a Simple Method for T-Cell Immunomonitoring.
Autorzy:
Jarzebska NT; Department of Dermatology, University Hospital Zürich (USZ), University of Zürich (UZH), Raemistrasse 100, 8091 Zürich, Switzerland.; Faculty of Science, University of Zürich, 8006 Zürich, Switzerland.
Frei J; Department of Dermatology, University Hospital Zürich (USZ), University of Zürich (UZH), Raemistrasse 100, 8091 Zürich, Switzerland.; Faculty of Medicine, University of Zürich, 8006 Zürich, Switzerland.
Lauchli S; Department of Dermatology, University Hospital Zürich (USZ), University of Zürich (UZH), Raemistrasse 100, 8091 Zürich, Switzerland.; Faculty of Medicine, University of Zürich, 8006 Zürich, Switzerland.
French LE; Department of Dermatology and Allergy, University Hospital, LMU Munich, 80539 Munich, Germany.; Dr. Philip Frost, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33146, USA.
Guenova E; Department of Dermatology, University Hospital Zürich (USZ), University of Zürich (UZH), Raemistrasse 100, 8091 Zürich, Switzerland.; Faculty of Medicine, University of Zürich, 8006 Zürich, Switzerland.; Department of Dermatology and Venereology, Faculty of Biology and Medicine, Lausanne University Hospital (CHUV), University of Lausanne, 1000 Lausanne, Switzerland.
Gouttefangeas C; Department of Immunology, University of Tübingen, 72074 Tübingen, Germany.
Kündig TM; Department of Dermatology, University Hospital Zürich (USZ), University of Zürich (UZH), Raemistrasse 100, 8091 Zürich, Switzerland.; Faculty of Medicine, University of Zürich, 8006 Zürich, Switzerland.
Mellett M; Department of Dermatology, University Hospital Zürich (USZ), University of Zürich (UZH), Raemistrasse 100, 8091 Zürich, Switzerland.; Faculty of Medicine, University of Zürich, 8006 Zürich, Switzerland.
Pascolo S; Department of Dermatology, University Hospital Zürich (USZ), University of Zürich (UZH), Raemistrasse 100, 8091 Zürich, Switzerland.; Faculty of Medicine, University of Zürich, 8006 Zürich, Switzerland.
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Źródło:
Viruses [Viruses] 2021 Jun 25; Vol. 13 (7). Date of Electronic Publication: 2021 Jun 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antigens/*genetics
Antigens/*immunology
Leukocytes, Mononuclear/*immunology
Monitoring, Immunologic/*methods
RNA, Messenger/*genetics
T-Lymphocytes/*immunology
Animals ; Cell Line ; Epitopes, T-Lymphocyte/genetics ; Epitopes, T-Lymphocyte/immunology ; Humans ; Immunity, Innate ; Influenza A virus/immunology ; Liposomes ; Mice ; Mice, Inbred C57BL ; Nanoparticles ; Spleen/cytology ; Transfection ; Viral Matrix Proteins/genetics ; Viral Matrix Proteins/immunology
Czasopismo naukowe
Tytuł:
CD112 Regulates Angiogenesis and T Cell Entry into the Spleen.
Autorzy:
Russo E; Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, CH-8093 Zurich, Switzerland.
Runge P; Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, CH-8093 Zurich, Switzerland.
Jahromi NH; Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, CH-8093 Zurich, Switzerland.
Naboth H; Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, CH-8093 Zurich, Switzerland.
Landtwing A; Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, CH-8093 Zurich, Switzerland.
Montecchi R; Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, CH-8093 Zurich, Switzerland.
Leicht N; Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, CH-8093 Zurich, Switzerland.
Hunter MC; Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, CH-8093 Zurich, Switzerland.
Takai Y; Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Chuo-ku Kobe 650-0047, Japan.
Halin C; Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, CH-8093 Zurich, Switzerland.
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Źródło:
Cells [Cells] 2021 Jan 15; Vol. 10 (1). Date of Electronic Publication: 2021 Jan 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neovascularization, Pathologic*
Nectins/*metabolism
Spleen/*metabolism
T-Lymphocytes/*metabolism
Animals ; Blood Vessels/metabolism ; Blood Vessels/pathology ; Capillary Permeability ; Cell Movement ; Endothelial Cells/metabolism ; Gene Expression Regulation ; Leukocytes/cytology ; Lymphatic Vessels/cytology ; Mice ; Mice, Inbred C57BL ; Microscopy, Fluorescence ; Neutrophils/metabolism ; Permeability ; Protein Binding ; T-Lymphocytes/cytology ; Virus Internalization
Czasopismo naukowe
Tytuł:
Homotaurine limits the spreading of T cell autoreactivity within the CNS and ameliorates disease in a model of multiple sclerosis.
Autorzy:
Tian J; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095-1735, USA. .
Song M; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095-1735, USA.
Kaufman DL; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095-1735, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Mar 08; Vol. 11 (1), pp. 5402. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Central Nervous System/*pathology
Multiple Sclerosis/*immunology
T-Lymphocytes/*immunology
Taurine/*analogs & derivatives
Animals ; Antigen Presentation/drug effects ; Antigen-Presenting Cells/drug effects ; Antigen-Presenting Cells/immunology ; Cell Proliferation/drug effects ; Central Nervous System/drug effects ; Central Nervous System/immunology ; Disease Models, Animal ; Disease Progression ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Female ; Mice, Inbred C57BL ; Multiple Sclerosis/pathology ; Myelin Proteolipid Protein/immunology ; Peptide Fragments/immunology ; Recurrence ; Spleen/pathology ; T-Lymphocytes/drug effects ; Taurine/pharmacology ; gamma-Aminobutyric Acid/pharmacology ; Mice
Czasopismo naukowe
Tytuł:
Effect of lead exposure and nutritional iron-deficiency on immune response: A vaccine challenge study in rats.
Autorzy:
Yathapu SR; Food and Drug Toxicology Research Center, ICMR-National Institute of Nutrition, Hyderabad, India.
Kondapalli NB; Department of Immunology and Micro-biology, ICMR-National Institute of Nutrition, Hyderabad, India.
Srivalliputturu SB; Food and Drug Toxicology Research Center, ICMR-National Institute of Nutrition, Hyderabad, India.
Hemalatha R; Department of Immunology and Micro-biology, ICMR-National Institute of Nutrition, Hyderabad, India.
Bharatraj DK; Food and Drug Toxicology Research Center, ICMR-National Institute of Nutrition, Hyderabad, India.
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Źródło:
Journal of immunotoxicology [J Immunotoxicol] 2020 Dec; Vol. 17 (1), pp. 144-152.
Typ publikacji:
Journal Article
MeSH Terms:
Anemia, Iron-Deficiency/*immunology
Lead/*toxicity
T-Lymphocytes/*immunology
Tetanus Toxoid/*immunology
Administration, Oral ; Anemia, Iron-Deficiency/blood ; Anemia, Iron-Deficiency/complications ; Anemia, Iron-Deficiency/diagnosis ; Animals ; Cell Proliferation/drug effects ; Cells, Cultured ; Cytokines/immunology ; Cytokines/metabolism ; Disease Models, Animal ; Female ; Hemoglobins/analysis ; Humans ; Immunity, Humoral/drug effects ; Immunity, Mucosal/drug effects ; Immunization, Secondary ; Immunogenicity, Vaccine ; Iron/blood ; Iron Deficiencies ; Lead/administration & dosage ; Lymphocyte Activation/drug effects ; Male ; Primary Cell Culture ; Rats ; Rats, Sprague-Dawley ; Spleen/cytology ; Spleen/immunology ; T-Lymphocytes/drug effects ; T-Lymphocytes/metabolism ; Tetanus Toxoid/administration & dosage ; Weaning
Czasopismo naukowe

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