- Tytuł:
- Synthesis, SAR and docking studies of substituted aryl phenylthiazolyl phenylcarboxamide as potential protein tyrosine phosphatase 1B (PTP1B) inhibitors.
- Autorzy:
- Źródło:
- Chemical biology & drug design [Chem Biol Drug Des] 2019 Jul; Vol. 94 (1), pp. 1378-1389. Date of Electronic Publication: 2019 Jun 05.
- Typ publikacji:
- Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
- MeSH Terms:
-
Molecular Docking Simulation*
Amides/*chemistryEnzyme Inhibitors /*chemical synthesis
Hypoglycemic Agents/*chemical synthesis
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*antagonists & inhibitors
Amides/metabolism ; Amides/therapeutic use ; Animals ; Binding Sites ; Blood Glucose/analysis ; Catalytic Domain ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/pathology ; Drug Design ;Enzyme Inhibitors /metabolism ;Enzyme Inhibitors /therapeutic use ; Glucose Tolerance Test ; Humans ; Hypoglycemic Agents/metabolism ; Hypoglycemic Agents/therapeutic use ; Hypolipidemic Agents/chemistry ; Hypolipidemic Agents/metabolism ; Hypolipidemic Agents/therapeutic use ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Structure-Activity Relationship
Czasopismo naukowe