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Wyszukujesz frazę ""Steroid 17-alpha-Hydroxylase"" wg kryterium: Temat


Tytuł :
Substrate-Specific Allosteric Effects on the Enhancement of CYP17A1 Lyase Efficiency by Cytochrome b5 .
Autorzy :
Liu Y; Department of Chemistry, Marquette University, 1414W Clybourn Street, Milwaukee, Wisconsin 53233, United States.
Denisov IG
Sligar SG
Kincaid JR; Department of Chemistry, Marquette University, 1414W Clybourn Street, Milwaukee, Wisconsin 53233, United States.
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2021 Mar 17; Vol. 143 (10), pp. 3729-3733. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cytochromes b5/*chemistry
Steroid 17-alpha-Hydroxylase/*metabolism
Allosteric Regulation ; Biocatalysis ; Catalytic Domain ; Cytochromes b5/metabolism ; Humans ; Pregnenolone/chemistry ; Pregnenolone/metabolism ; Steroid 17-alpha-Hydroxylase/chemistry ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Multidisciplinary team management of 46,XY 17α-hydroxylase deficiency: a case report and literature review.
Autorzy :
Zhou Y; Department of Gynecology, Affiliated Hospital of Northwestern Polytechnical University, Xi'an, Shaanxi, China.
Xue X; Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Shi P; Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Lu Q; Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Lv S; Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
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Źródło :
The Journal of international medical research [J Int Med Res] 2021 Mar; Vol. 49 (3), pp. 300060521993965.
Typ publikacji :
Case Reports; Journal Article; Review
MeSH Terms :
Adrenal Hyperplasia, Congenital*/diagnosis
Adrenal Hyperplasia, Congenital*/drug therapy
Adrenal Hyperplasia, Congenital*/genetics
Steroid 17-alpha-Hydroxylase*/genetics
Adolescent ; Female ; Humans ; Male ; Mutation ; Patient Care Team ; Quality of Life
Czasopismo naukowe
Tytuł :
Is the unique benzodiazepine structure interacting with CYP enzymes to affect steroid synthesis in vitro?
Autorzy :
Johannsen ML; Toxicology and Drug Metabolism Group, Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen OE, Denmark.
Munkboel CH; Toxicology and Drug Metabolism Group, Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen OE, Denmark.
Jørgensen FS; Section of Biostructural Research, Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen, OE, Denmark.
Styrishave B; Toxicology and Drug Metabolism Group, Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen OE, Denmark. Electronic address: .
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Źródło :
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2021 Jan; Vol. 205, pp. 105765. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article
MeSH Terms :
Benzodiazepines/*chemistry
Endocrine Disruptors/*chemistry
Steroid 17-alpha-Hydroxylase/*chemistry
Steroid 21-Hydroxylase/*chemistry
Steroids/*biosynthesis
Adrenal Cortex Hormones/chemistry ; Adrenal Cortex Hormones/pharmacology ; Adrenal Glands/drug effects ; Alprazolam/chemistry ; Alprazolam/pharmacology ; Androgens/genetics ; Benzodiazepines/pharmacology ; Diazepam/chemistry ; Diazepam/pharmacology ; Endocrine Disruptors/pharmacology ; Humans ; Molecular Docking Simulation ; Oxazepam/chemistry ; Oxazepam/pharmacology ; Receptors, Androgen/chemistry ; Receptors, Androgen/genetics ; Receptors, GABA-A/chemistry ; Receptors, GABA-A/genetics ; Steroid 17-alpha-Hydroxylase/antagonists & inhibitors ; Steroid 17-alpha-Hydroxylase/genetics ; Steroid 21-Hydroxylase/antagonists & inhibitors ; Steroid 21-Hydroxylase/genetics ; Steroids/chemistry
Czasopismo naukowe
Tytuł :
Modified bile acids and androstanes-Novel promising inhibitors of human cytochrome P450 17A1.
Autorzy :
Dzichenka Y; Institute of Bioorganic Chemistry NAS of Belarus, Kuprevicha Street, 5/2 Minsk, 220141, Belarus. Electronic address: .
Shapira M; Institute of Bioorganic Chemistry NAS of Belarus, Kuprevicha Street, 5/2 Minsk, 220141, Belarus.
Yantsevich A; Institute of Bioorganic Chemistry NAS of Belarus, Kuprevicha Street, 5/2 Minsk, 220141, Belarus.
Cherkesova T; Institute of Bioorganic Chemistry NAS of Belarus, Kuprevicha Street, 5/2 Minsk, 220141, Belarus.
Grbović L; University of Novi Sad Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg Dositeja Obradovića 3, Novi Sad, 21000, Serbia.
Savić M; University of Novi Sad Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg Dositeja Obradovića 3, Novi Sad, 21000, Serbia.
Usanov S; Institute of Bioorganic Chemistry NAS of Belarus, Kuprevicha Street, 5/2 Minsk, 220141, Belarus.
Jovanović-Šanta S; University of Novi Sad Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg Dositeja Obradovića 3, Novi Sad, 21000, Serbia.
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Źródło :
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2021 Jan; Vol. 205, pp. 105777. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Androstanes/*chemistry
Bile Acids and Salts/*chemistry
Cytochrome P-450 Enzyme Inhibitors/*chemistry
Steroid 17-alpha-Hydroxylase/*chemistry
Androstanes/pharmacology ; Bile Acids and Salts/pharmacology ; Cytochrome P-450 Enzyme Inhibitors/pharmacology ; Cytochrome P-450 Enzyme System/chemistry ; Cytochrome P-450 Enzyme System/genetics ; Humans ; Ligands ; Progesterone/genetics ; Steroid 17-alpha-Hydroxylase/antagonists & inhibitors ; Steroid 17-alpha-Hydroxylase/genetics ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
P450 CYP17A1 Variant with a Disordered Proton Shuttle Assembly Retains Peroxo-Mediated Lyase Efficiency.
Autorzy :
Liu Y; Department of Chemistry, Marquette University, 1414W Clybourn Street, Milwaukee, WI, 53233, USA.
Denisov IG; Departments of Biochemistry and Chemistry, University of Illinois, 116 Morrill Hall, 505 S. Goodwin Avenue, Urbana, IL, 61801, USA.
Grinkova YV; Departments of Biochemistry and Chemistry, University of Illinois, 116 Morrill Hall, 505 S. Goodwin Avenue, Urbana, IL, 61801, USA.
Sligar SG; Departments of Biochemistry and Chemistry, University of Illinois, 116 Morrill Hall, 505 S. Goodwin Avenue, Urbana, IL, 61801, USA.
Kincaid JR; Department of Chemistry, Marquette University, 1414W Clybourn Street, Milwaukee, WI, 53233, USA.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Dec 15; Vol. 26 (70), pp. 16846-16852. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article
MeSH Terms :
Protons*
Lyases/*genetics
Lyases/*metabolism
Steroid 17-alpha-Hydroxylase/*genetics
Steroid 17-alpha-Hydroxylase/*metabolism
Humans ; Lyases/chemistry ; Pregnenolone ; Progesterone ; Steroid 17-alpha-Hydroxylase/chemistry
Czasopismo naukowe
Tytuł :
Terazosin reduces steroidogenic factor 1 and upregulates heat shock protein 90 expression in LH-induced bovine ovarian theca cells.
Autorzy :
Tang ZR; College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Deng SL; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.
Lian ZX; College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Yu K; College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China. Electronic address: .
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Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2021 Feb 01; Vol. 163, pp. 190-195. Date of Electronic Publication: 2020 Dec 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Steroid 17-alpha-Hydroxylase*
Theca Cells*
Animals ; Cattle ; Cells, Cultured ; Female ; Heat-Shock Proteins ; Humans ; Prazosin/analogs & derivatives ; Steroidogenic Factor 1/genetics
Czasopismo naukowe
Tytuł :
Tight binding of cytochrome b 5 to cytochrome P450 17A1 is a critical feature of stimulation of C21 steroid lyase activity and androgen synthesis.
Autorzy :
Kim D; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA; Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea.
Kim V; Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea.
McCarty KD; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Guengerich FP; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100571. Date of Electronic Publication: 2021 Mar 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Androgens/*biosynthesis
Cytochromes b5/*metabolism
Lyases/*metabolism
Steroid 17-alpha-Hydroxylase/*metabolism
Humans ; Kinetics ; Mutation ; Protein Binding ; Steroid 17-alpha-Hydroxylase/genetics
Czasopismo naukowe
Tytuł :
Functional Analysis of Steroidogenic Factor 1 (sf-1) and 17α-Hydroxylase/Lyase (cyp17α) Promoters in Yellow Catfish Pelteobagrus fulvidraco .
Autorzy :
Lv WH; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Chen GH; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Zhuo MQ; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Xu YH; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Xu YC; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Tan XY; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 27; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 27.
Typ publikacji :
Journal Article
MeSH Terms :
Promoter Regions, Genetic*
Catfishes/*genetics
Gene Expression Regulation/*genetics
Steroid 17-alpha-Hydroxylase/*genetics
Steroidogenic Factor 1/*genetics
Animals ; Binding Sites ; Catfishes/metabolism ; Cloning, Molecular ; Genes, Reporter ; HEK293 Cells ; Humans ; Leptin/metabolism ; Luciferases/metabolism ; Mutation ; PPAR alpha/genetics ; PPAR alpha/metabolism ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Protein Binding ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Steroid 17-alpha-Hydroxylase/metabolism ; Steroidogenic Factor 1/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Premature Adrenarche in Girls Characterized By Enhanced 17,20-Lyase and 17β-Hydroxysteroid Dehydrogenase Activities.
Autorzy :
Janner M; Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Bern University Hospital, University of Bern, Bern, Switzerland.
Sommer G; Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Bern University Hospital, University of Bern, Bern, Switzerland.; Department of Biomedical Research, University of Bern, Bern, Switzerland.
Groessl M; Department of Biomedical Research, University of Bern, Bern, Switzerland.; Department of Nephrology, Bern University Hospital, University of Bern, Bern, Switzerland.
Flück CE; Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Bern University Hospital, University of Bern, Bern, Switzerland.; Department of Biomedical Research, University of Bern, Bern, Switzerland.
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Źródło :
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2020 Dec 01; Vol. 105 (12).
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
17-Hydroxysteroid Dehydrogenases/*blood
Adrenarche/*blood
Puberty, Precocious/*blood
Steroid 17-alpha-Hydroxylase/*blood
17-Hydroxysteroid Dehydrogenases/metabolism ; Adrenarche/metabolism ; Adrenarche/physiology ; Androgens/blood ; Androgens/metabolism ; Case-Control Studies ; Child ; Child, Preschool ; Corticosterone/blood ; Corticosterone/metabolism ; Estrogens/blood ; Estrogens/metabolism ; Female ; Humans ; Hydrocortisone/blood ; Hydrocortisone/metabolism ; Metabolome ; Puberty, Precocious/metabolism ; Steroid 17-alpha-Hydroxylase/metabolism ; Switzerland ; Up-Regulation
Czasopismo naukowe
Tytuł :
Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome.
Autorzy :
Mihanfar A; Department of Clinical Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Nouri M; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Roshangar L; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Khadem-Ansari MH; Department of Clinical Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Electronic address: .
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Źródło :
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2021 Oct; Vol. 213, pp. 105954. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Flavonols/*pharmacology
Letrozole/*antagonists & inhibitors
Ovary/*drug effects
Polycystic Ovary Syndrome/*drug therapy
AMP-Activated Protein Kinases/blood ; AMP-Activated Protein Kinases/genetics ; Animals ; Blood Glucose/metabolism ; Carboxymethylcellulose Sodium/administration & dosage ; Catalase/blood ; Catalase/genetics ; Disease Models, Animal ; Estradiol/blood ; Female ; Gene Expression ; Glutathione Peroxidase/blood ; Glutathione Peroxidase/genetics ; Humans ; Insulin/blood ; Letrozole/toxicity ; Metformin/pharmacology ; Ovary/metabolism ; Ovary/pathology ; Polycystic Ovary Syndrome/blood ; Polycystic Ovary Syndrome/chemically induced ; Polycystic Ovary Syndrome/pathology ; Progesterone/blood ; Rats ; Rats, Wistar ; Sirtuin 1/blood ; Sirtuin 1/genetics ; Steroid 17-alpha-Hydroxylase/antagonists & inhibitors ; Steroid 17-alpha-Hydroxylase/blood ; Steroid 17-alpha-Hydroxylase/genetics ; Superoxide Dismutase/blood ; Superoxide Dismutase/genetics ; Testosterone/blood
Czasopismo naukowe
Tytuł :
Effect of the spatial-temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouse.
Autorzy :
Secchi C; Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of California San Diego, La Jolla, CA, USA. .
Belli M; Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Harrison TNH; Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Swift J; The Salk Institute for Biological Studies, La Jolla, CA, USA.
Ko C; Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Duleba AJ; Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Stupack D; Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Chang RJ; Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Shimasaki S; Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of California San Diego, La Jolla, CA, USA.
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Źródło :
Journal of translational medicine [J Transl Med] 2021 Oct 15; Vol. 19 (1), pp. 428. Date of Electronic Publication: 2021 Oct 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Polycystic Ovary Syndrome*
Theca Cells*
Androgens/pharmacology ; Animals ; Cytochrome P450 Family 17 ; Female ; Humans ; Male ; Mice ; Phenotype ; Steroid 17-alpha-Hydroxylase/genetics
Czasopismo naukowe
Tytuł :
The broad phenotypic spectrum of 17α-hydroxylase/17,20-lyase (CYP17A1) deficiency: a case series.
Autorzy :
Sun M; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Mueller JW; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Gilligan LC; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Taylor AE; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Shaheen F; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Noczyńska A; Department of Endocrinology and Diabetology for Children and Adolescents, Wroclaw Medical University, Wroclaw, Poland.
T'Sjoen G; Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.
Denvir L; Department of Paediatric Endocrinology and Diabetes, Queen's Medical Centre, Nottingham, UK.
Shenoy S; Children's and Adolescent Services, University Hospitals of Leicester NHS Trust, Leicester, UK.
Fulton P; West Midlands Regional Genetics Service, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
Cheetham TD; Newcastle University c/o Department of Paediatric Endocrinology, Royal Victoria Infirmary, Newcastle Upon Tyne, UK.
Gleeson H; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Department of Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Rahman M; Department of Endocrinology, Northwick Park Hospital, London Northwest University Healthcare NHS Trust, London, UK.
Krone NP; Academic Unit of Child Health, Department of Oncology & Metabolism, University of Sheffield, Sheffield, UK.
Taylor NF; Department of Clinical Biochemistry, King's College Hospital, London, UK.
Shackleton CHL; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Benioff Children's Hospital, University of California San Francisco, Oakland, California, USA.
Arlt W; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Idkowiak J; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Department of Endocrinology and Diabetes, Birmingham Children's Hospital, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
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Źródło :
European journal of endocrinology [Eur J Endocrinol] 2021 Oct 11; Vol. 185 (5), pp. 729-741. Date of Electronic Publication: 2021 Oct 11.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Steroid 17-alpha-Hydroxylase/*genetics
Adolescent ; Adrenal Hyperplasia, Congenital/genetics ; Amenorrhea/genetics ; Computer Simulation ; Corticosterone/urine ; Failure to Thrive/enzymology ; Failure to Thrive/genetics ; Female ; Gas Chromatography-Mass Spectrometry ; Gonadal Steroid Hormones/deficiency ; Gynecomastia/etiology ; Gynecomastia/genetics ; HEK293 Cells ; Humans ; Hydrocortisone/deficiency ; Infant ; Infant, Newborn ; Male ; Mineralocorticoids/metabolism ; Mutation/genetics ; Phenotype ; Steroids/urine ; Young Adult
Czasopismo naukowe
Tytuł :
The effects of selected inhibitors on human fetal adrenal steroidogenesis differs under basal and ACTH-stimulated conditions.
Autorzy :
Melau C; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.; International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Riis ML; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.; International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Nielsen JE; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.; International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Perlman S; Department of Gynaecology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Lundvall L; Department of Gynaecology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Thuesen LL; Department of Obstetrics and Gynaecology, Copenhagen University Hospital - Hvidovre and Amager Hospital, Hvidovre, Denmark.
Hare KJ; Department of Obstetrics and Gynaecology, Copenhagen University Hospital - Hvidovre and Amager Hospital, Hvidovre, Denmark.
Hammerum MS; Department of Obstetrics and Gynaecology, Copenhagen University Hospital - Herlev and Gentofte Hospital, Herlev, Denmark.
Mitchell RT; MRC Centre for Reproductive Health, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.
Frederiksen H; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.; International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Juul A; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.; International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Jørgensen A; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen, Denmark. .; International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark. .
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Źródło :
BMC medicine [BMC Med] 2021 Sep 08; Vol. 19 (1), pp. 204. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adrenal Glands*
Adrenocorticotropic Hormone*
Female ; Fetus ; Humans ; Steroid 17-alpha-Hydroxylase ; Steroid 21-Hydroxylase ; Steroids
Czasopismo naukowe
Tytuł :
Characteristics of steroidogenesis-related factors in the musk gland of Chinese forest musk deer (Moschus berezovskii).
Autorzy :
Yang J; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China; Biology Research Centre of Qin Mountains Wildlife, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Peng G; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China; Biology Research Centre of Qin Mountains Wildlife, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Shu F; College of Forestry, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Dong D; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China; Biology Research Centre of Qin Mountains Wildlife, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Zheng X; College of Forestry, Northwest A&F University, Yangling, Shaanxi, 712100, China; Biology Research Centre of Qin Mountains Wildlife, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Zhu C; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China; Biology Research Centre of Qin Mountains Wildlife, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Li X; College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Ma J; Shaanxi Reed Musk Deer Industry Co., Ltd., Meixian, Shaanxi, 722307, China.
Pan C; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Yang F; College of Forestry, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address: .
Dong W; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China; Biology Research Centre of Qin Mountains Wildlife, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address: .
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Źródło :
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2021 Sep; Vol. 212, pp. 105916. Date of Electronic Publication: 2021 May 16.
Typ publikacji :
Journal Article
MeSH Terms :
3-Hydroxysteroid Dehydrogenases/*genetics
Cholesterol Side-Chain Cleavage Enzyme/*genetics
Deer/*genetics
Deer/*metabolism
Exocrine Glands/*metabolism
Steroid 17-alpha-Hydroxylase/*genetics
Testis/*metabolism
Androgens/metabolism ; Animals ; Fatty Acids, Monounsaturated/metabolism ; Male ; Phylogeny ; Testosterone/metabolism ; Transcriptome
Czasopismo naukowe
Tytuł :
Intratumoral steroid profiling of adrenal cortisol-producing adenomas by liquid chromatography- mass spectrometry.
Autorzy :
Teuber JP; Department of Pharmacology, University of Michigan, Ann Arbor, MI, 48109, USA.
Nanba K; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, 612-8555, Japan.
Turcu AF; Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Chen X; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA.
Zhao L; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA.
Else T; Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Auchus RJ; Department of Pharmacology, University of Michigan, Ann Arbor, MI, 48109, USA; Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Rainey WE; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Rege J; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address: .
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Źródło :
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2021 Sep; Vol. 212, pp. 105924. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Adenoma/*metabolism
Adrenal Cortex Neoplasms/*metabolism
Cushing Syndrome/*metabolism
Steroids/*metabolism
Adenoma/blood ; Adrenal Cortex Neoplasms/blood ; Adult ; Chromatography, Liquid ; Cushing Syndrome/blood ; Female ; Humans ; Male ; Middle Aged ; Progesterone Reductase/metabolism ; Steroid 17-alpha-Hydroxylase/metabolism ; Steroids/blood ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
[Clinical characteristics and CYP17A1 gene mutation analysis in patients with 17α-hydroxylase/17, 20-lyase deficiency and testicular tumor].
Autorzy :
Han BB; Department of Endocrinology, Henan Provincial People's Hospital, Zhengzhou 450003, China Department of Endocrinology, People's Hospital of Henan University, Zhengzhou 450003, China.
Zheng RZ; Department of Endocrinology, Henan Provincial People's Hospital, Zhengzhou 450003, China Department of Endocrinology, People's Hospital of Henan University, Zhengzhou 450003, China.
Xie YD; Department of Endocrinology, Henan Provincial People's Hospital, Zhengzhou 450003, China Department of Endocrinology, People's Hospital of Henan University, Zhengzhou 450003, China.
Chen YQ; Department of Endocrinology, Henan Provincial People's Hospital, Zhengzhou 450003, China.
Niu JP; Department of Endocrinology, Henan Provincial People's Hospital, Zhengzhou 450003, China.
Zhang Y; Department of Endocrinology, Henan Provincial People's Hospital, Zhengzhou 450003, China.
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Źródło :
Zhonghua nei ke za zhi [Zhonghua Nei Ke Za Zhi] 2021 Sep 01; Vol. 60 (9), pp. 827-830.
Typ publikacji :
Journal Article
MeSH Terms :
Adrenal Hyperplasia, Congenital*/genetics
Lyases*
Testicular Neoplasms*/genetics
Female ; Humans ; Male ; Mixed Function Oxygenases ; Mutation ; Retrospective Studies ; Steroid 17-alpha-Hydroxylase/genetics
Czasopismo naukowe
Tytuł :
Changes in Adrenal Androgens and Steroidogenic Enzyme Activities From Ages 2, 4, to 6 Years: A Prospective Cohort Study.
Autorzy :
Kim JH; Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.
Lee YA; Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.
Lim YH; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea.; Environmental Health Center, Seoul National University College of Medicine, Seoul, Korea.
Lee K; Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Kim BN; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
Kim JI; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
Hong YC; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea.; Environmental Health Center, Seoul National University College of Medicine, Seoul, Korea.; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Yang SW; Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.
Song J; Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Shin CH; Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.
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Źródło :
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2020 Oct 01; Vol. 105 (10).
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
3-Hydroxysteroid Dehydrogenases/*blood
Adrenarche/*blood
Androgens/*blood
Steroid 17-alpha-Hydroxylase/*blood
Sulfotransferases/*blood
17-Hydroxysteroid Dehydrogenases/blood ; 17-Hydroxysteroid Dehydrogenases/metabolism ; 17-alpha-Hydroxyprogesterone/blood ; 17-alpha-Hydroxyprogesterone/metabolism ; 3-Hydroxysteroid Dehydrogenases/metabolism ; Adrenarche/metabolism ; Androgens/metabolism ; Androstenedione/blood ; Androstenedione/metabolism ; Child ; Child, Preschool ; Dehydroepiandrosterone Sulfate/blood ; Dehydroepiandrosterone Sulfate/metabolism ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Male ; Prospective Studies ; Steroid 17-alpha-Hydroxylase/metabolism ; Sulfotransferases/metabolism ; Zona Reticularis/metabolism
Czasopismo naukowe
Tytuł :
Altered expression of CYP17A1 and CYP19A1 in undescended testes of dogs with unilateral cryptorchidism.
Autorzy :
Krzeminska P; Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 35, 60-637, Poznan, Poland.
Stachowiak M; Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 35, 60-637, Poznan, Poland.
Skrzypski M; Department of Animal Physiology, Biochemistry and Biostructure, Poznan University of Life Sciences, Wolynska 35, 60-637, Poznan, Poland.
Nowak T; Department of Animal Reproduction, Poznan University of Life Sciences, Wolynska 35, 60-637, Poznan, Poland.
Maslak A; Vital-Vet Veterinary Surgery, sw. Floriana 4, 62-045, Pniewy, Poland.
Switonski M; Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 35, 60-637, Poznan, Poland.
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Źródło :
Animal genetics [Anim Genet] 2020 Oct; Vol. 51 (5), pp. 763-771. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Journal Article
MeSH Terms :
Aromatase/*genetics
Cryptorchidism/*veterinary
Dog Diseases/*genetics
Steroid 17-alpha-Hydroxylase/*genetics
Animals ; Aromatase/metabolism ; Cryptorchidism/genetics ; Dogs ; Male ; Steroid 17-alpha-Hydroxylase/metabolism
Czasopismo naukowe
Tytuł :
Flash glucose monitoring system was applied to cortisol treatment for a patient with congenital adrenal hyperplasia and 17α-hydroxylase deficiency.
Autorzy :
Xiang C; Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030000, China.
Han M; Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030000, China.; First Clinical Medical College, Shanxi Medical University, Taiyuan, 030000, China.
Zhang Y; Department of Pharmacology, Shanxi Medical University, Taiyuan, 030000, China.
Yin J; Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030000, China.
Pei L; Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030000, China.
Yang J; Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030000, China. .
Liu Y; Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030000, China. .
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Źródło :
BMC endocrine disorders [BMC Endocr Disord] 2020 Sep 21; Vol. 20 (1), pp. 144. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Adrenal Hyperplasia, Congenital/*drug therapy
Blood Glucose/*analysis
Blood Glucose Self-Monitoring/*methods
Hydrocortisone/*therapeutic use
Steroid 17-alpha-Hydroxylase/*metabolism
Adrenal Hyperplasia, Congenital/complications ; Adrenal Hyperplasia, Congenital/metabolism ; Adrenal Hyperplasia, Congenital/pathology ; Adrenocorticotropic Hormone/metabolism ; Adult ; Anti-Inflammatory Agents/therapeutic use ; Female ; Humans ; Prognosis ; Steroid 17-alpha-Hydroxylase/genetics
Czasopismo naukowe
Tytuł :
[Clinical and genetic analysis of a patient with 17-hydroxylase/17,20-lyase deficiency].
Autorzy :
Zeng Y; Xiamen Maternal and Child Health Care Hospital, Women and Children's Hospital Affiliated to Xiamen University, Xiamen Key Laboratory of Reproductive Genetics, Xiamen, Fujian 361003, China. pingli .
Mei L
Liang L
He X
Gao H
Lin S
Huang L
Li P
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Źródło :
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics [Zhonghua Yi Xue Yi Chuan Xue Za Zhi] 2020 Sep 10; Vol. 37 (9), pp. 997-1000.
Typ publikacji :
Journal Article
MeSH Terms :
Adrenal Hyperplasia, Congenital*/diagnosis
Adrenal Hyperplasia, Congenital*/genetics
Steroid 17-alpha-Hydroxylase*/genetics
Female ; Genetic Testing ; Heterozygote ; Homozygote ; Humans ; Mutation
Czasopismo naukowe

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