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Wyszukujesz frazę ""Steroid 17-alpha-Hydroxylase"" wg kryterium: Temat


Wyświetlanie 1-18 z 18
Tytuł:
Promising Tools in Prostate Cancer Research: Selective Non-Steroidal Cytochrome P450 17A1 Inhibitors.
Autorzy:
Bonomo S; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen Ø, Denmark.
Hansen CH; Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
Petrunak EM; Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Dr., Lawrence, KS, 66045 USA.
Scott EE; Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Dr., Lawrence, KS, 66045 USA.
Styrishave B; Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
Jørgensen FS; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen Ø, Denmark.
Olsen L; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen Ø, Denmark.
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Źródło:
Scientific reports [Sci Rep] 2016 Jul 12; Vol. 6, pp. 29468. Date of Electronic Publication: 2016 Jul 12.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Design*
Prostatic Neoplasms/*blood
Prostatic Neoplasms/*drug therapy
Steroid 17-alpha-Hydroxylase/*antagonists & inhibitors
Androstenes/pharmacology ; Catalytic Domain ; Cell Line, Tumor ; Cell Survival ; Chromatography, Liquid ; Crystallography, X-Ray ; Humans ; Inhibitory Concentration 50 ; Ligands ; Male ; Mass Spectrometry ; Molecular Docking Simulation ; Nitrogen/chemistry ; Prostate/metabolism ; Protein Binding ; Steroid 17-alpha-Hydroxylase/blood ; Steroid 17-alpha-Hydroxylase/metabolism ; Steroids
Czasopismo naukowe
Tytuł:
Testicular steroidogenesis is suppressed during experimental autoimmune encephalomyelitis in rats.
Autorzy:
Milosevic A; Department for Neurobiology, Institute for Biological Research 'Siniša Stanković'-National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11000, Belgrade, Serbia.
Bjelobaba I; Department for Neurobiology, Institute for Biological Research 'Siniša Stanković'-National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11000, Belgrade, Serbia.
Bozic ID; Department for Neurobiology, Institute for Biological Research 'Siniša Stanković'-National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11000, Belgrade, Serbia.
Lavrnja I; Department for Neurobiology, Institute for Biological Research 'Siniša Stanković'-National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11000, Belgrade, Serbia.
Savic D; Department for Neurobiology, Institute for Biological Research 'Siniša Stanković'-National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11000, Belgrade, Serbia.
Tesovic K; Department for Neurobiology, Institute for Biological Research 'Siniša Stanković'-National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11000, Belgrade, Serbia.
Jakovljevic M; Department for Neurobiology, Institute for Biological Research 'Siniša Stanković'-National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11000, Belgrade, Serbia.
Stojilkovic SS; Section on Cellular Signaling, Eunice Kennedy Shriver National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Janjic MM; Department for Neurobiology, Institute for Biological Research 'Siniša Stanković'-National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11000, Belgrade, Serbia. .
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Źródło:
Scientific reports [Sci Rep] 2021 Apr 26; Vol. 11 (1), pp. 8996. Date of Electronic Publication: 2021 Apr 26.
Typ publikacji:
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Encephalomyelitis, Autoimmune, Experimental/*metabolism
Multiple Sclerosis/*metabolism
Testis/*metabolism
Testosterone/*biosynthesis
Animals ; Cholesterol Side-Chain Cleavage Enzyme/biosynthesis ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Gene Expression Regulation, Enzymologic ; Male ; Multienzyme Complexes/biosynthesis ; Multiple Sclerosis/pathology ; Progesterone Reductase/biosynthesis ; Rats ; Steroid 17-alpha-Hydroxylase/biosynthesis ; Steroid Isomerases/biosynthesis ; Testis/pathology
Czasopismo naukowe
Tytuł:
Targeting of CYP17A1 Lyase by VT-464 Inhibits Adrenal and Intratumoral Androgen Biosynthesis and Tumor Growth of Castration Resistant Prostate Cancer.
Autorzy:
Maity SN; Department of Genitourinary Medical Oncology, David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Titus MA; Department of Genitourinary Medical Oncology, David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Gyftaki R; Department of Oncology, Alexandra Hospital, University of Athens, Athens, Greece.
Wu G; Department of Genitourinary Medical Oncology, David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Lu JF; Department of Genitourinary Medical Oncology, David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Ramachandran S; Department of Genitourinary Medical Oncology, David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Li-Ning-Tapia EM; Department of Genitourinary Medical Oncology, David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Logothetis CJ; Department of Genitourinary Medical Oncology, David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Araujo JC; Department of Genitourinary Medical Oncology, David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Efstathiou E; Department of Genitourinary Medical Oncology, David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Oncology, Alexandra Hospital, University of Athens, Athens, Greece.
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Źródło:
Scientific reports [Sci Rep] 2016 Oct 17; Vol. 6, pp. 35354. Date of Electronic Publication: 2016 Oct 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Naphthalenes/*administration & dosage
Prostatic Neoplasms, Castration-Resistant/*drug therapy
Receptors, Androgen/*metabolism
Steroid 17-alpha-Hydroxylase/*antagonists & inhibitors
Triazoles/*administration & dosage
Abiraterone Acetate/administration & dosage ; Androgens/biosynthesis ; Animals ; Biopsy ; Cell Line, Tumor ; Dehydroepiandrosterone/chemistry ; Humans ; Hydrocortisone/blood ; Male ; Mass Spectrometry ; Mice ; Mice, SCID ; Neoplasm Transplantation ; Precision Medicine ; Prednisone/administration & dosage ; Receptors, Androgen/genetics ; Signal Transduction ; Steroid 17-alpha-Hydroxylase/metabolism
Czasopismo naukowe
Tytuł:
CYP17A1 deficient XY mice display susceptibility to atherosclerosis, altered lipidomic profile and atypical sex development.
Autorzy:
Aherrahrou R; Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany.; Centre for Public Health Genomics, Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
Kulle AE; Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.
Alenina N; Max-Delbrück-Center for Molecular Medicine (MDC), Robert-Rössle-Str. 10, 13125, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.
Werner R; Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, University of Lübeck, Lübeck, Germany.; Institute of Molecular Medicine, University of Lübeck, Lübeck, Germany.
Vens-Cappell S; Bioanalytical Core Facility, CBBM (Center of Brain Behavior and Metabolism), University of Lübeck, Lübeck, Germany.
Bader M; Max-Delbrück-Center for Molecular Medicine (MDC), Robert-Rössle-Str. 10, 13125, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Charité-Universitätsmedizin, Berlin, Germany.; Institute for Biology, University of Lübeck, Lübeck, Germany.
Schunkert H; Kardiologie, Deutsches Herzzentrum München, Technische Universität München and DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Erdmann J; Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Germany, University Heart Centre Lübeck, 23562, Lübeck, Germany.
Aherrahrou Z; Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany. .; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Germany, University Heart Centre Lübeck, 23562, Lübeck, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2020 May 29; Vol. 10 (1), pp. 8792. Date of Electronic Publication: 2020 May 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Atherosclerosis/*genetics
Infertility/*genetics
Lipidomics/*methods
Steroid 17-alpha-Hydroxylase/*genetics
Steroids/*blood
Animals ; Atherosclerosis/blood ; Atherosclerosis/chemically induced ; Chromatography, Liquid ; Diet, Western/adverse effects ; Disease Models, Animal ; Female ; Infertility/blood ; Male ; Mass Spectrometry ; Mice ; Mice, Knockout ; Phenotype
Czasopismo naukowe
Tytuł:
Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001.
Autorzy:
DeVore NM; Department of Medicinal Chemistry, 1251 Wescoe Hall Drive, University of Kansas, Lawrence, Kansas 66045, USA.
Scott EE
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Źródło:
Nature [Nature] 2012 Jan 22; Vol. 482 (7383), pp. 116-9. Date of Electronic Publication: 2012 Jan 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Prostatic Neoplasms*/drug therapy
Androstadienes/*chemistry
Androstenols/*chemistry
Antineoplastic Agents/*chemistry
Benzimidazoles/*chemistry
Steroid 17-alpha-Hydroxylase/*antagonists & inhibitors
Steroid 17-alpha-Hydroxylase/*chemistry
Androstadienes/metabolism ; Androstenes ; Androstenols/metabolism ; Antineoplastic Agents/metabolism ; Benzimidazoles/metabolism ; Biocatalysis/drug effects ; Catalytic Domain ; Crystallography, X-Ray ; Humans ; Hydrogen Bonding ; Ligands ; Male ; Models, Molecular ; Protein Conformation ; Receptors, Androgen/chemistry ; Receptors, Androgen/metabolism ; Steroid 17-alpha-Hydroxylase/metabolism ; United States ; United States Food and Drug Administration
Czasopismo naukowe
Tytuł:
Interaction between CYP1A1/CYP17A1 polymorphisms and parental risk factors in the risk of hypospadias in a Chinese population.
Autorzy:
Mao Y; Department of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, 110034, China.; Editorial Department of Journal of Shenyang Medical College, Shenyang Medical College, Shenyang, Liaoning Province, 110034, China.
Zhang K; Department of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, 110034, China.
Ma L; Department of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, 110034, China.
Yun X; Department of Clinical Nutrition, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, 110001, China.
Ou F; Department of Clinical Nutrition, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, 110001, China.
Liu G; Department of Pediatric Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, 110004, China.
Yang Y; Department of Pediatric Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, 110004, China.
Zhang Y; Department of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, 110034, China.
Pei X; Department of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, 110034, China.
Duan Z; Department of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, 110034, China.
Ma M; Department of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, 110034, China. .
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Źródło:
Scientific reports [Sci Rep] 2019 Mar 11; Vol. 9 (1), pp. 4123. Date of Electronic Publication: 2019 Mar 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Polymorphism, Single Nucleotide*
Cytochrome P-450 CYP1A1/*genetics
Hypospadias/*genetics
Steroid 17-alpha-Hydroxylase/*genetics
Adolescent ; Child ; China ; Gene-Environment Interaction ; Humans ; Hypospadias/epidemiology ; Male ; Socioeconomic Factors
Czasopismo naukowe
Tytuł:
A high-fat diet impairs reproduction by decreasing the IL1β level in mice treated at immature stage.
Autorzy:
Zhang J; Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, China.
Li K; Division of Experimental Oncology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.
Yuan M; Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, China.
Zhang J; Division of Experimental Oncology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.
Huang G; Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, China.
Ao J; Division of Experimental Oncology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.
Tan H; Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, China.
Li Y; Division of Experimental Oncology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.
Gong D; Division of Experimental Oncology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.
Li J; Division of Experimental Oncology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.
Kang L; Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, China.
An N; Department of Pediatric Surgery, Provincial People's Hospital, Guizhou, China.
Li F; Department of Pediatric Surgery, Provincial People's Hospital, Guizhou, China.
Lin P; Division of Experimental Oncology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China. .
Huang L; Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, China. .
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Źródło:
Scientific reports [Sci Rep] 2017 Apr 03; Vol. 7 (1), pp. 567. Date of Electronic Publication: 2017 Apr 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diet, High-Fat*/adverse effects
Reproduction*/genetics
Reproduction*/immunology
Interleukin-1beta/*metabolism
Age Factors ; Animals ; Apoptosis ; Cholesterol Side-Chain Cleavage Enzyme/genetics ; Cholesterol Side-Chain Cleavage Enzyme/metabolism ; Germ Cells/metabolism ; Immunohistochemistry ; Inflammasomes/metabolism ; Macrophages/immunology ; Macrophages/metabolism ; Male ; Mice ; Steroid 17-alpha-Hydroxylase/genetics ; Steroid 17-alpha-Hydroxylase/metabolism ; Testis/metabolism ; Testis/pathology ; Testosterone/metabolism
Czasopismo naukowe
Tytuł:
Serum sex steroid hormone levels and polymorphisms of CYP17 and SRD5A2: implication for prostate cancer risk.
Autorzy:
Kakinuma H; Department of Urology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
Tsuchiya N
Habuchi T
Ohyama C
Matsuura S
Wang L
Nakamura A
Kato T
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Źródło:
Prostate cancer and prostatic diseases [Prostate Cancer Prostatic Dis] 2004; Vol. 7 (4), pp. 333-7.
Typ publikacji:
Journal Article
MeSH Terms:
Polymorphism, Genetic*
3-Oxo-5-alpha-Steroid 4-Dehydrogenase/*genetics
Androstenedione/*blood
Biomarkers, Tumor/*blood
Prostatic Neoplasms/*genetics
Steroid 17-alpha-Hydroxylase/*genetics
Testosterone/*blood
3-Oxo-5-alpha-Steroid 4-Dehydrogenase/blood ; Aged ; Aged, 80 and over ; Androgens/blood ; Cohort Studies ; DNA, Neoplasm/blood ; DNA, Neoplasm/genetics ; Genotype ; Humans ; Japan/epidemiology ; Male ; Middle Aged ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/epidemiology ; Risk Factors ; Steroid 17-alpha-Hydroxylase/blood
Czasopismo naukowe
Tytuł:
No association of the 5' promoter region polymorphism of CYP17 gene with prostate cancer risk.
Autorzy:
dos Santos A; Centro de Biologia Molecular e Engenharia Genética, Universidade Estadual De Campinas, Sáo Paulo, Brazil.
Ribeiro ML
Mesquita JC
Carvalho-Salles AB
Hackel C
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Źródło:
Prostate cancer and prostatic diseases [Prostate Cancer Prostatic Dis] 2002; Vol. 5 (1), pp. 28-31.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Genetic Predisposition to Disease*
Polymorphism, Genetic*
Promoter Regions, Genetic/*genetics
Prostate/*metabolism
Prostatic Neoplasms/*genetics
Steroid 17-alpha-Hydroxylase/*genetics
Adult ; Aged ; Brazil/epidemiology ; Case-Control Studies ; Gene Frequency ; Genotype ; Humans ; Male ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Prostate/pathology ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/epidemiology ; Risk Factors ; Steroid 17-alpha-Hydroxylase/blood
Czasopismo naukowe
Tytuł:
Conversion of abiraterone to D4A drives anti-tumour activity in prostate cancer.
Autorzy:
Li Z; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Bishop AC; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Alyamani M; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Garcia JA; 1] Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA [2] Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Dreicer R; 1] Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA [2] Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Bunch D; Department of Laboratory Medicine, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Liu J; Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Upadhyay SK; Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Auchus RJ; 1] Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Sharifi N; 1] Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA [2] Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA [3] Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
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Źródło:
Nature [Nature] 2015 Jul 16; Vol. 523 (7560), pp. 347-51. Date of Electronic Publication: 2015 Jun 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Androstenes/*metabolism
Androstenes/*pharmacology
Prostatic Neoplasms/*drug therapy
Prostatic Neoplasms/*metabolism
3-Hydroxysteroid Dehydrogenases/antagonists & inhibitors ; 3-Hydroxysteroid Dehydrogenases/metabolism ; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/metabolism ; 5-alpha Reductase Inhibitors/metabolism ; 5-alpha Reductase Inhibitors/pharmacology ; 5-alpha Reductase Inhibitors/therapeutic use ; Androgen Receptor Antagonists/metabolism ; Androgen Receptor Antagonists/pharmacology ; Androgen Receptor Antagonists/therapeutic use ; Androgens/biosynthesis ; Androgens/metabolism ; Androstenes/chemistry ; Androstenes/therapeutic use ; Animals ; Benzamides ; Biosynthetic Pathways/drug effects ; Biotransformation ; Cell Division ; Chromatin/metabolism ; Dihydrotestosterone/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice ; Nitriles ; Phenylthiohydantoin/analogs & derivatives ; Phenylthiohydantoin/pharmacology ; Prostatic Neoplasms/enzymology ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Receptors, Androgen/metabolism ; Steroid 17-alpha-Hydroxylase/antagonists & inhibitors ; Steroid 17-alpha-Hydroxylase/metabolism ; Survival Analysis ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
Retinoic acid receptor beta and angiopoietin-like protein 1 are involved in the regulation of human androgen biosynthesis.
Autorzy:
Udhane SS; Pediatric Endocrinology and Diabetology, Department of Pediatrics, University Children's Hospital, Inselspital.; The Department of Clinical Research, University of Bern, 3010 Bern, Switzerland.
Pandey AV; Pediatric Endocrinology and Diabetology, Department of Pediatrics, University Children's Hospital, Inselspital.; The Department of Clinical Research, University of Bern, 3010 Bern, Switzerland.
Hofer G; Pediatric Endocrinology and Diabetology, Department of Pediatrics, University Children's Hospital, Inselspital.; The Department of Clinical Research, University of Bern, 3010 Bern, Switzerland.
Mullis PE; Pediatric Endocrinology and Diabetology, Department of Pediatrics, University Children's Hospital, Inselspital.; The Department of Clinical Research, University of Bern, 3010 Bern, Switzerland.
Flück CE; Pediatric Endocrinology and Diabetology, Department of Pediatrics, University Children's Hospital, Inselspital.; The Department of Clinical Research, University of Bern, 3010 Bern, Switzerland.
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Źródło:
Scientific reports [Sci Rep] 2015 May 13; Vol. 5, pp. 10132. Date of Electronic Publication: 2015 May 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Androgens/*biosynthesis
Angiopoietins/*metabolism
Receptors, Retinoic Acid/*metabolism
Adrenal Glands/metabolism ; Angiopoietin-Like Protein 1 ; Angiopoietin-like Proteins ; Cell Cycle ; Cell Line ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Regulatory Networks ; Humans ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Models, Biological ; Nuclear Receptor Subfamily 4, Group A, Member 1/metabolism ; Progesterone Reductase/metabolism ; Protein Binding ; Steroid 17-alpha-Hydroxylase/genetics ; Steroids/biosynthesis
Czasopismo naukowe
Tytuł:
Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis.
Autorzy:
Yuan X; Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Cai C; Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Chen S; Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Chen S; Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Yu Z; Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Balk SP; Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
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Źródło:
Oncogene [Oncogene] 2014 May 29; Vol. 33 (22), pp. 2815-25. Date of Electronic Publication: 2013 Jun 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Drug Resistance, Neoplasm*
Prostatic Neoplasms, Castration-Resistant/*metabolism
Receptors, Androgen/*metabolism
Androgen Receptor Antagonists/therapeutic use ; Androgens/metabolism ; Animals ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/genetics ; Receptors, Androgen/chemistry ; Repressor Proteins/metabolism ; Steroid 17-alpha-Hydroxylase/antagonists & inhibitors ; Steroid 17-alpha-Hydroxylase/metabolism ; Trans-Activators/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł:
Association of common variants in/near six genes (ATP2B1, CSK, MTHFR, CYP17A1, STK39 and FGF5) with blood pressure/hypertension risk in Chinese children.
Autorzy:
Xi B; 1] Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China [2] Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan, China.
Shen Y
Zhao X
Chandak GR
Cheng H
Hou D
Li Y
Ott J
Zhang Y
Wang X
Mi J
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Źródło:
Journal of human hypertension [J Hum Hypertens] 2014 Jan; Vol. 28 (1), pp. 32-6. Date of Electronic Publication: 2013 Jun 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Polymorphism, Single Nucleotide*
Asian People/*genetics
Blood Pressure/*genetics
Hypertension/*genetics
Adolescent ; CSK Tyrosine-Protein Kinase ; Child ; China ; Cross-Sectional Studies ; Female ; Fibroblast Growth Factor 5/genetics ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genotype ; Humans ; Male ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics ; Plasma Membrane Calcium-Transporting ATPases/genetics ; Protein Serine-Threonine Kinases/genetics ; Risk ; Steroid 17-alpha-Hydroxylase/genetics ; src-Family Kinases/genetics
Czasopismo naukowe
Tytuł:
A sex-specific effect of the CYP17A1 SNP rs11191548 on blood pressure in Chinese children.
Autorzy:
Wu L; Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
Xi B
Zhang M
Shen Y
Zhao X
Wang T
Cheng H
Hou D
Liu G
Wang X
Mi J
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Źródło:
Journal of human hypertension [J Hum Hypertens] 2012 Dec; Vol. 26 (12), pp. 731-6. Date of Electronic Publication: 2011 Nov 03.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Sex Factors*
Asian People/*genetics
Blood Pressure/*genetics
Hypertension/*genetics
Polymorphism, Single Nucleotide/*genetics
Steroid 17-alpha-Hydroxylase/*genetics
Adolescent ; Asian People/ethnology ; Blood Pressure/physiology ; Child ; China ; Comorbidity ; Cross-Sectional Studies ; Diastole/genetics ; Diastole/physiology ; Female ; Genotype ; Humans ; Hypertension/epidemiology ; Hypertension/ethnology ; Male ; Obesity/epidemiology ; Obesity/ethnology ; Obesity/genetics ; Risk Factors ; Systole/genetics ; Systole/physiology
Czasopismo naukowe
Tytuł:
Emerging therapeutic approaches in the management of metastatic castration-resistant prostate cancer.
Autorzy:
Antonarakis ES; Prostate Cancer Research Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231-1000, USA. />Armstrong AJ
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Źródło:
Prostate cancer and prostatic diseases [Prostate Cancer Prostatic Dis] 2011 Sep; Vol. 14 (3), pp. 206-18. Date of Electronic Publication: 2011 May 17.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Prostatic Neoplasms/*pathology
Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Disease Management ; Humans ; Male ; Molecular Targeted Therapy ; Neoplasm Metastasis ; Orchiectomy ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/surgery ; Randomized Controlled Trials as Topic ; Steroid 17-alpha-Hydroxylase/antagonists & inhibitors ; Treatment Failure
Czasopismo naukowe
Tytuł:
Comprehensive association analyses of IGF1, ESR2, and CYP17 genes with adult height in Caucasians.
Autorzy:
Yang TL; The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, PR China.
Xiong DH
Guo Y
Recker RR
Deng HW
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Źródło:
European journal of human genetics : EJHG [Eur J Hum Genet] 2008 Nov; Vol. 16 (11), pp. 1380-7. Date of Electronic Publication: 2008 Jun 18.
Typ publikacji:
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Polymorphism, Single Nucleotide*
Body Height/*genetics
Estrogen Receptor beta/*genetics
Insulin-Like Growth Factor I/*genetics
Steroid 17-alpha-Hydroxylase/*genetics
White People/*genetics
Female ; Humans ; Linkage Disequilibrium ; Male ; Sex Characteristics ; Sex Factors
Czasopismo naukowe
Tytuł:
Comprehensive evaluation of the association between prostate cancer and genotypes/haplotypes in CYP17A1, CYP3A4, and SRD5A2.
Autorzy:
Loukola A; Amersham Biosciences, Sunnyvale, CA 94085, USA.
Chadha M
Penn SG
Rank D
Conti DV
Thompson D
Cicek M
Love B
Bivolarevic V
Yang Q
Jiang Y
Hanzel DK
Dains K
Paris PL
Casey G
Witte JS
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Źródło:
European journal of human genetics : EJHG [Eur J Hum Genet] 2004 Apr; Vol. 12 (4), pp. 321-32.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Haplotypes*
3-Oxo-5-alpha-Steroid 4-Dehydrogenase/*genetics
Cytochrome P-450 Enzyme System/*genetics
Prostatic Neoplasms/*genetics
Steroid 17-alpha-Hydroxylase/*genetics
Case-Control Studies ; Cytochrome P-450 CYP3A ; Genotype ; Humans ; Male ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł:
The potential role of periovarian fat and leptin in initiation of puberty in the immature rat.
Autorzy:
Cannady WE; Department of Physiology and Endocrinology, Medical College of Georgia, Augusta 30912-3000, USA.
Brann DW
Mahesh VB
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Źródło:
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity [Int J Obes Relat Metab Disord] 2000 Jun; Vol. 24 Suppl 2, pp. S146-7.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Adipose Tissue/*metabolism
Leptin/*physiology
Ovary/*metabolism
Sexual Maturation/*physiology
Animals ; Aromatase/genetics ; Cholesterol Side-Chain Cleavage Enzyme/genetics ; Estradiol/metabolism ; Female ; Kinetics ; Leptin/administration & dosage ; Progesterone/metabolism ; RNA, Messenger/metabolism ; Rats ; Recombinant Proteins/administration & dosage ; Steroid 17-alpha-Hydroxylase/genetics ; Testosterone/metabolism
Czasopismo naukowe
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