Temat: "Steroid 17-alpha-Hydroxylase" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: The Multienzyme Complex Nature of Dehydroepiandrosterone Sulfate Biosynthesis.
Autorzy:: Tumilovich A; Institute of Bioorganic Chemistry NASB, 5 Building 2, V.F. Kuprevich Street, 220141 Minsk, Belarus.
Yablokov E; Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.
Mezentsev Y; Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.
Ershov P; Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.
Basina V; Research Centre for Medical Genetics, 1 Moskvorechye Street, 115522 Moscow, Russia.
Gnedenko O; Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.
Kaluzhskiy L; Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.
Tsybruk T; Institute of Bioorganic Chemistry NASB, 5 Building 2, V.F. Kuprevich Street, 220141 Minsk, Belarus.
Grabovec I; Institute of Bioorganic Chemistry NASB, 5 Building 2, V.F. Kuprevich Street, 220141 Minsk, Belarus.
Kisel M; Institute of Bioorganic Chemistry NASB, 5 Building 2, V.F. Kuprevich Street, 220141 Minsk, Belarus.
Shabunya P; Institute of Bioorganic Chemistry NASB, 5 Building 2, V.F. Kuprevich Street, 220141 Minsk, Belarus.
Soloveva N; Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.
Vavilov N; Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.
Gilep A; Institute of Bioorganic Chemistry NASB, 5 Building 2, V.F. Kuprevich Street, 220141 Minsk, Belarus.; Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.
Ivanov A; Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 08; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 08.
Typ publikacji:: Journal Article
MeSH Terms:: Multienzyme Complexes*/metabolism
Steroid 17-alpha-Hydroxylase*/metabolism
Dehydroepiandrosterone Sulfate ; Oxidation-Reduction ; Steroids ; Surface Plasmon Resonance ; Sulfotransferases/genetics ; Sulfotransferases/metabolism

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Skocz do pozycji: 2.

Tytuł:: Full-term live birth in a woman with 17α-hydroxylase and 17,20-lyase deficiency with assisted reproductive technology: a case report.
Autorzy:: Xi S; Peking University First Hospital Obstetric and Gynecology Department Reproductive and Genetic Center, No.1 Xi'an Men Street, Xi Cheng District, Beijing, China.
Yang X; Peking University First Hospital Obstetric and Gynecology Department Reproductive and Genetic Center, No.1 Xi'an Men Street, Xi Cheng District, Beijing, China.
Shan X; Peking University First Hospital Obstetric and Gynecology Department Reproductive and Genetic Center, No.1 Xi'an Men Street, Xi Cheng District, Beijing, China.
Xue Q; Peking University First Hospital Obstetric and Gynecology Department Reproductive and Genetic Center, No.1 Xi'an Men Street, Xi Cheng District, Beijing, China. .; Pokaż więcej
Źródło:: BMC women's health [BMC Womens Health] 2023 Aug 04; Vol. 23 (1), pp. 408. Date of Electronic Publication: 2023 Aug 04.
Typ publikacji:: Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Steroid 17-alpha-Hydroxylase*/genetics
Live Birth*
Humans ; Female ; Pregnancy ; Adult ; Progesterone ; Mixed Function Oxygenases ; Cesarean Section ; Dexamethasone

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Skocz do pozycji: 3.

Tytuł:: Exploring the Chemical Space of CYP17A1 Inhibitors Using Cheminformatics and Machine Learning.
Autorzy:: Yu T; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong (Shenzhen), Shenzhen 518172, China.; Center of Data Mining and Biomedical informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
Huang T; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong (Shenzhen), Shenzhen 518172, China.
Yu L; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai 200438, China.
Nantasenamat C; Streamlit Open Source, Snowflake Inc., San Mateo, CA 94402, USA.
Anuwongcharoen N; Center of Data Mining and Biomedical informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
Piacham T; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
Ren R; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai 200438, China.; Shanghai Qi Zhi Institute, Shanghai 200030, China.
Chiang YC; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong (Shenzhen), Shenzhen 518172, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Feb 09; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 09.
Typ publikacji:: Journal Article
MeSH Terms:: Cheminformatics*
Enzyme Inhibitors*/pharmacology
Steroid 17-alpha-Hydroxylase*/antagonists & inhibitors
Dehydroepiandrosterone ; Machine Learning ; Quantitative Structure-Activity Relationship ; Steroids/chemistry

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Skocz do pozycji: 4.

Tytuł:: Synthesis and Structure-Activity Relationships of Novel Non-Steroidal CYP17A1 Inhibitors as Potential Prostate Cancer Agents.
Autorzy:: Wróbel TM; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.; Department of Synthesis and Chemical Technology of Pharmaceutical Substances, Medical University of Lublin, Chodźki 4a, 20093 Lublin, Poland.
Rogova O; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Sharma K; Division of Pediatric Endocrinology, Department of Pediatrics, University Children's Hospital Bern, 3010 Bern, Switzerland.; Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland.
Rojas Velazquez MN; Division of Pediatric Endocrinology, Department of Pediatrics, University Children's Hospital Bern, 3010 Bern, Switzerland.; Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland.
Pandey AV; Division of Pediatric Endocrinology, Department of Pediatrics, University Children's Hospital Bern, 3010 Bern, Switzerland.; Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland.
Jørgensen FS; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Arendrup FS; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen, Denmark.
Andersen KL; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen, Denmark.
Björkling F; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2022 Jan 20; Vol. 12 (2). Date of Electronic Publication: 2022 Jan 20.
Typ publikacji:: Journal Article
MeSH Terms:: Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/pharmacology
Prostatic Neoplasms*/drug therapy
Prostatic Neoplasms*/enzymology
Steroid 17-alpha-Hydroxylase*/antagonists & inhibitors
Humans ; Male ; PC-3 Cells ; Structure-Activity Relationship

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Skocz do pozycji: 5.

Tytuł:: P450 CYP17A1 Variant with a Disordered Proton Shuttle Assembly Retains Peroxo-Mediated Lyase Efficiency.
Autorzy:: Liu Y; Department of Chemistry, Marquette University, 1414W Clybourn Street, Milwaukee, WI, 53233, USA.
Denisov IG; Departments of Biochemistry and Chemistry, University of Illinois, 116 Morrill Hall, 505 S. Goodwin Avenue, Urbana, IL, 61801, USA.
Grinkova YV; Departments of Biochemistry and Chemistry, University of Illinois, 116 Morrill Hall, 505 S. Goodwin Avenue, Urbana, IL, 61801, USA.
Sligar SG; Departments of Biochemistry and Chemistry, University of Illinois, 116 Morrill Hall, 505 S. Goodwin Avenue, Urbana, IL, 61801, USA.
Kincaid JR; Department of Chemistry, Marquette University, 1414W Clybourn Street, Milwaukee, WI, 53233, USA.; Pokaż więcej
Źródło:: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Dec 15; Vol. 26 (70), pp. 16846-16852. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji:: Journal Article
MeSH Terms:: Protons*
Lyases/*genetics
Lyases/*metabolism
Steroid 17-alpha-Hydroxylase/*genetics
Steroid 17-alpha-Hydroxylase/*metabolism
Humans ; Lyases/chemistry ; Pregnenolone ; Progesterone ; Steroid 17-alpha-Hydroxylase/chemistry

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Skocz do pozycji: 6.

Tytuł:: Functional Analysis of Steroidogenic Factor 1 (sf-1) and 17α-Hydroxylase/Lyase (cyp17α) Promoters in Yellow Catfish Pelteobagrus fulvidraco .
Autorzy:: Lv WH; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Chen GH; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Zhuo MQ; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Xu YH; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Xu YC; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Tan XY; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Dec 27; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 27.
Typ publikacji:: Journal Article
MeSH Terms:: Promoter Regions, Genetic*
Catfishes/*genetics
Gene Expression Regulation/*genetics
Steroid 17-alpha-Hydroxylase/*genetics
Steroidogenic Factor 1/*genetics
Animals ; Binding Sites ; Catfishes/metabolism ; Cloning, Molecular ; Genes, Reporter ; HEK293 Cells ; Humans ; Leptin/metabolism ; Luciferases/metabolism ; Mutation ; PPAR alpha/genetics ; PPAR alpha/metabolism ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Protein Binding ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Steroid 17-alpha-Hydroxylase/metabolism ; Steroidogenic Factor 1/metabolism ; Up-Regulation

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Skocz do pozycji: 7.

Tytuł:: Altered expression of CYP17A1 and CYP19A1 in undescended testes of dogs with unilateral cryptorchidism.
Autorzy:: Krzeminska P; Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 35, 60-637, Poznan, Poland.
Stachowiak M; Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 35, 60-637, Poznan, Poland.
Skrzypski M; Department of Animal Physiology, Biochemistry and Biostructure, Poznan University of Life Sciences, Wolynska 35, 60-637, Poznan, Poland.
Nowak T; Department of Animal Reproduction, Poznan University of Life Sciences, Wolynska 35, 60-637, Poznan, Poland.
Maslak A; Vital-Vet Veterinary Surgery, sw. Floriana 4, 62-045, Pniewy, Poland.
Switonski M; Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 35, 60-637, Poznan, Poland.; Pokaż więcej
Źródło:: Animal genetics [Anim Genet] 2020 Oct; Vol. 51 (5), pp. 763-771. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji:: Journal Article
MeSH Terms:: Aromatase/*genetics
Cryptorchidism/*veterinary
Dog Diseases/*genetics
Steroid 17-alpha-Hydroxylase/*genetics
Animals ; Aromatase/metabolism ; Cryptorchidism/genetics ; Dogs ; Male ; Steroid 17-alpha-Hydroxylase/metabolism

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Skocz do pozycji: 8.

Tytuł:: Flash glucose monitoring system was applied to cortisol treatment for a patient with congenital adrenal hyperplasia and 17α-hydroxylase deficiency.
Autorzy:: Xiang C; Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030000, China.
Han M; Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030000, China.; First Clinical Medical College, Shanxi Medical University, Taiyuan, 030000, China.
Zhang Y; Department of Pharmacology, Shanxi Medical University, Taiyuan, 030000, China.
Yin J; Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030000, China.
Pei L; Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030000, China.
Yang J; Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030000, China. .
Liu Y; Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030000, China. .; Pokaż więcej
Źródło:: BMC endocrine disorders [BMC Endocr Disord] 2020 Sep 21; Vol. 20 (1), pp. 144. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Adrenal Hyperplasia, Congenital/*drug therapy
Blood Glucose/*analysis
Blood Glucose Self-Monitoring/*methods
Hydrocortisone/*therapeutic use
Steroid 17-alpha-Hydroxylase/*metabolism
Adrenal Hyperplasia, Congenital/complications ; Adrenal Hyperplasia, Congenital/metabolism ; Adrenal Hyperplasia, Congenital/pathology ; Adrenocorticotropic Hormone/metabolism ; Adult ; Anti-Inflammatory Agents/therapeutic use ; Female ; Humans ; Prognosis ; Steroid 17-alpha-Hydroxylase/genetics

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Skocz do pozycji: 9.

Tytuł:: New benzothieno[2,3- c ]pyridines as non-steroidal CYP17 inhibitors: design, synthesis, anticancer screening, apoptosis induction, and in silico ADME profile studies.
Autorzy:: Khalil NA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Ahmed EM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Zaher AF; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Sobh EA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt.
El-Sebaey SA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
El-Zoghbi MS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1839-1859.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Enzyme Inhibitors/*chemistry
Enzyme Inhibitors/*pharmacology
Pyridines/*chemistry
Pyridines/*pharmacology
Steroid 17-alpha-Hydroxylase/*antagonists & inhibitors
Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacokinetics ; Biological Availability ; Cell Line, Tumor ; Computer Simulation ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/pharmacokinetics ; Humans ; Male ; Mice ; Prostatic Neoplasms/pathology ; Pyridines/chemical synthesis ; Pyridines/pharmacokinetics ; Spectrum Analysis/methods ; Xenograft Model Antitumor Assays

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Skocz do pozycji: 10.

Tytuł:: Diagnosis of female 17α-hydroxylase deficiency after gonadectomy: a case report.
Autorzy:: Mikami Y; Department of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe City, Saitama, 350-3550, Japan. .
Takai Y; Department of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe City, Saitama, 350-3550, Japan.
Obata-Yasuoka M; Department of Obstetrics and Gynecology Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Kumagai R; Department of Endocrinology and Metabolism Tsukuba University Hospital Mito Clinical Education and Training Center, Mito Kyodo General Hospital, Ibaraki, Japan.
Yagyu H; Department of Endocrinology and Metabolism Tsukuba University Hospital Mito Clinical Education and Training Center, Mito Kyodo General Hospital, Ibaraki, Japan.
Shigematsu K; Department of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe City, Saitama, 350-3550, Japan.
Huang H; Department of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe City, Saitama, 350-3550, Japan.
Uemura N; Department of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe City, Saitama, 350-3550, Japan.
Shinsaka M; Department of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe City, Saitama, 350-3550, Japan.
Saitoh M; Department of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe City, Saitama, 350-3550, Japan.
Baba K; Department of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe City, Saitama, 350-3550, Japan.
Seki H; Department of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe City, Saitama, 350-3550, Japan.; Pokaż więcej
Źródło:: Journal of medical case reports [J Med Case Rep] 2019 Jul 30; Vol. 13 (1), pp. 235. Date of Electronic Publication: 2019 Jul 30.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Steroid 17-alpha-Hydroxylase*
Adrenal Hyperplasia, Congenital/*genetics
Adrenal Hyperplasia, Congenital/diagnosis ; Castration ; Child ; Delayed Diagnosis ; Female ; Genetic Counseling ; Humans ; Mutation, Missense

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Skocz do pozycji: 11.

Tytuł:: Association of the CYP17 and CYP19 gene polymorphisms in women with polycystic ovary syndrome from Punjab, Pakistan.
Autorzy:: Munawar Lone N; Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan.
Babar S; Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan.
Sultan S; Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan.
Malik S; Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan.
Nazeer K; Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan.
Riaz S; Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan.; Citi Lab and Research Centre, Lahore, Pakistan.; Pokaż więcej
Źródło:: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2021 May; Vol. 37 (5), pp. 456-461. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji:: Journal Article
MeSH Terms:: Aromatase/*genetics
Polycystic Ovary Syndrome/*genetics
Steroid 17-alpha-Hydroxylase/*genetics
Adult ; Case-Control Studies ; Female ; Humans ; Polymorphism, Genetic ; Young Adult

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Skocz do pozycji: 12.

Tytuł:: CYP17 gene polymorphic sequence variation is associated with hyperandrogenism in Kashmiri women with polycystic ovarian syndrome.
Autorzy:: Ashraf S; Department of Biochemistry, University of Kashmir, Srinagar, India.
Rasool SUA; Department of Biotechnology, University of Kashmir, Srinagar, India.
Nabi M; Department of Biochemistry, University of Kashmir, Srinagar, India.
Ganie MA; Department of Endocrinology, Sher-e-Kashmir Institute of Medical Sciences, Srinagar, India.
Jabeen F; Department of Obstetrics and Gynecology, LD Hospital, Government Medical College, Srinagar, India.
Rashid F; Department of Clinical Biochemistry, University of Kashmir, Srinagar, India.
Amin S; Department of Biochemistry, University of Kashmir, Srinagar, India.; Pokaż więcej
Źródło:: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2021 Mar; Vol. 37 (3), pp. 230-234. Date of Electronic Publication: 2020 May 27.
Typ publikacji:: Journal Article
MeSH Terms:: Hyperandrogenism/*genetics
Polycystic Ovary Syndrome/*genetics
Steroid 17-alpha-Hydroxylase/*genetics
Adolescent ; Adult ; Anovulation/genetics ; Case-Control Studies ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Hyperandrogenism/complications ; Hyperandrogenism/epidemiology ; India/epidemiology ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/epidemiology ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Young Adult

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Skocz do pozycji: 13.

Tytuł:: Effect of glucocorticoids on androgen biosynthesis in the testes of the toad Rhinella arenarum (Amphibia, Anura).
Autorzy:: Czuchlej SC; Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
Volonteri MC; Instituto de Diversidad y Evolución Austral (IDEAus CENPAT-CONICET), Puerto Madryn, Chubut, Argentina.
Regueira E; Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.; Instituto de Biodiversidad y Biología Experimental y Aplicada (IBBEA UBA- CONICET), Buenos Aires, Argentina.
Ceballos NR; Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.; Pokaż więcej
Źródło:: Journal of experimental zoology. Part A, Ecological and integrative physiology [J Exp Zool A Ecol Integr Physiol] 2019 Jan; Vol. 331 (1), pp. 17-26. Date of Electronic Publication: 2018 Sep 15.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: 11-beta-Hydroxysteroid Dehydrogenase Type 1/*metabolism
Androgens/*biosynthesis
Bufonidae/*metabolism
Corticosterone/*pharmacology
Steroid 17-alpha-Hydroxylase/*metabolism
Testis/*drug effects
11-beta-Hydroxysteroid Dehydrogenase Type 1/genetics ; Animals ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/pharmacology ; Corticosterone/administration & dosage ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Gene Expression Regulation/drug effects ; Glycyrrhetinic Acid/administration & dosage ; Glycyrrhetinic Acid/pharmacology ; Male ; Mifepristone ; Steroid 17-alpha-Hydroxylase/genetics ; Testis/metabolism ; Tissue Culture Techniques

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Skocz do pozycji: 14.

Tytuł:: A rare intronic mutation in the splice acceptor site of the CYP17A1 gene in a patient with 17α-hydroxylase/17,20-lyase deficiency.
Autorzy:: Guo X; Department of Urology, Shandong Provincial Hospital, affiliated to Shandong First Medical University, Jinan, China.
Wang H; Department of Urology, Shandong Provincial Hospital, affiliated to Shandong First Medical University, Jinan, China.
Xiang Y; Department of Urology, Shandong Provincial Hospital, affiliated to Shandong First Medical University, Jinan, China.
Ren X; Department of Urology, Shandong Provincial Hospital, affiliated to Shandong First Medical University, Jinan, China.
Jiang S; Department of Urology, Shandong Provincial Hospital, affiliated to Shandong First Medical University, Jinan, China.; Pokaż więcej
Źródło:: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2021 Jan; Vol. 37 (1), pp. 97-100. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Adrenal Hyperplasia, Congenital/*genetics
Cytochrome P-450 Enzyme System/*deficiency
RNA Splice Sites/*genetics
Steroid 17-alpha-Hydroxylase/*genetics
Adult ; Codon, Nonsense ; Cytochrome P-450 Enzyme System/genetics ; Female ; Humans ; Introns
SCR Disease Name:: 17,20-Lyase Deficiency, Isolated

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Skocz do pozycji: 15.

Tytuł:: The mole genome reveals regulatory rearrangements associated with adaptive intersexuality.
Autorzy:: M Real F; RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Institute for Medical and Human Genetics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Haas SA; Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Franchini P; Chair in Zoology and Evolutionary Biology, Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Xiong P; Chair in Zoology and Evolutionary Biology, Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Simakov O; Department of Molecular Evolution and Development, University of Vienna, 1090 Vienna, Austria.
Kuhl H; Department of Ecophysiology and Aquaculture, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Berlin, Germany.
Schöpflin R; RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Institute for Medical and Human Genetics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Heller D; Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Moeinzadeh MH; Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Heinrich V; Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Krannich T; Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Bressin A; Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Hartmann MF; Steroid Research & Mass Spectrometry Unit, Laboratory for Translational Hormone Analytics in Paediatric Endocrinology, Division of Paediatric Endocrinology & Diabetology, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany.
Wudy SA; Steroid Research & Mass Spectrometry Unit, Laboratory for Translational Hormone Analytics in Paediatric Endocrinology, Division of Paediatric Endocrinology & Diabetology, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany.
Dechmann DKN; Department of Migration and Immuno-Ecology, Max Planck Institute for Animal Behavior, Radolfzell, Germany.; Department of Biology, University of Konstanz, Konstanz, Germany.
Hurtado A; Departamento de Genética, Universidad de Granada, Granada, Spain.; Instituto de Biotecnología, Centro de Investigación Biomédica, Universidad de Granada, Armilla, Granada, Spain.
Barrionuevo FJ; Departamento de Genética, Universidad de Granada, Granada, Spain.; Instituto de Biotecnología, Centro de Investigación Biomédica, Universidad de Granada, Armilla, Granada, Spain.
Schindler M; RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Institute for Medical and Human Genetics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Harabula I; RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Osterwalder M; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.; Department for BioMedical Research (DBMR), University of Bern, 3008 Bern, Switzerland.
Hiller M; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.; Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany.; Center for Systems Biology Dresden, 01307 Dresden, Germany.
Wittler L; Department of Developmental Genetics, Transgenic Unit, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Visel A; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.; U.S. Department of Energy Joint Genome Institute, Berkeley, CA 94720, USA.; School of Natural Sciences, University of California, Merced, CA 95343, USA.
Timmermann B; RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Meyer A; Chair in Zoology and Evolutionary Biology, Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Vingron M; Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Jiménez R; Departamento de Genética, Universidad de Granada, Granada, Spain.; Instituto de Biotecnología, Centro de Investigación Biomédica, Universidad de Granada, Armilla, Granada, Spain.
Mundlos S; RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany. .; Institute for Medical and Human Genetics, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany.
Lupiáñez DG; RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany. .; Institute for Medical and Human Genetics, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany.; Epigenetics and Sex Development Group, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin, Germany.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2020 Oct 09; Vol. 370 (6513), pp. 208-214.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Regulatory Elements, Transcriptional*
Adaptation, Physiological/*genetics
Fibroblast Growth Factor 9/*genetics
Moles/*genetics
Sex Differentiation/*genetics
Steroid 17-alpha-Hydroxylase/*genetics
Animals ; Chromosome Inversion ; Datasets as Topic ; Female ; Gene Expression Regulation ; Genome ; Mice ; Mice, Transgenic ; Tandem Repeat Sequences ; Testosterone/blood ; Testosterone/genetics

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Skocz do pozycji: 16.

Tytuł:: CYP17 inhibitors improve the prognosis of metastatic castration-resistant prostate cancer patients: A meta-analysis of published trials.
Autorzy:: Cao Q; Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Bai P; Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Shi D; Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Liao J; Department of Nursing, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Shi H; Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xing Y; Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chen K; Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhang X; Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Pokaż więcej
Źródło:: Journal of cancer research and therapeutics [J Cancer Res Ther] 2020 Sep; Vol. 16 (5), pp. 990-1001.
Typ publikacji:: Journal Article; Meta-Analysis
MeSH Terms:: Abiraterone Acetate/*therapeutic use
Cytochrome P-450 Enzyme Inhibitors/*therapeutic use
Prostate-Specific Antigen/*blood
Prostatic Neoplasms, Castration-Resistant/*drug therapy
Steroid 17-alpha-Hydroxylase/*antagonists & inhibitors
Clinical Trials, Phase III as Topic ; Humans ; Male ; Prognosis ; Prostatic Neoplasms, Castration-Resistant/pathology ; Randomized Controlled Trials as Topic ; Survival Rate

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Skocz do pozycji: 17.

Tytuł:: A rare cause of delayed puberty in two cases with 46,XX and 46,XY karyotype: 17 α-hydroxylase deficiency due to a novel variant in CYP17A1 gene.
Autorzy:: Unal E; Department of Pediatric Endocrinology, Dicle University Medical Faculty, Diyarbakir, Turkey.
Yıldırım R; Department of Pediatric Endocrinology, Diyarbakır Children's Hospital, Diyarbakir, Turkey.
Taş FF; Department of Pediatric Endocrinology, Dicle University Medical Faculty, Diyarbakir, Turkey.
Tekin S; Department of Pediatrics, Dicle University Medical Faculty, Diyarbakir, Turkey.
Ceylaner S; Intergen Genetic Diagnosis Center, Department of Medical Genetics, Ankara, Turkey.
Haspolat YK; Department of Pediatric Endocrinology, Dicle University Medical Faculty, Diyarbakir, Turkey.; Pokaż więcej
Źródło:: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2020 Aug; Vol. 36 (8), pp. 739-742. Date of Electronic Publication: 2019 Dec 30.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Polymorphism, Single Nucleotide*
46, XX Disorders of Sex Development/*genetics
Disorder of Sex Development, 46,XY/*genetics
Puberty, Delayed/*genetics
Steroid 17-alpha-Hydroxylase/*genetics
46, XX Disorders of Sex Development/diagnosis ; Adolescent ; Adrenal Hyperplasia, Congenital/diagnosis ; Adrenal Hyperplasia, Congenital/genetics ; Disorder of Sex Development, 46,XY/diagnosis ; Female ; Humans ; Karyotype ; Mutation, Missense ; Puberty, Delayed/diagnosis

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Skocz do pozycji: 18.

Tytuł:: Discovery of Novel Non-Steroidal Cytochrome P450 17A1 Inhibitors as Potential Prostate Cancer Agents.
Autorzy:: Wróbel TM; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.; Department of Synthesis and Chemical Technology of Pharmaceutical Substances, Medical University of Lublin, Chodźki 4a, 20093 Lublin, Poland.
Rogova O; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Andersen KL; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen, Denmark.
Yadav R; Department of Medicinal Chemistry, University of Michigan, 428 Church Street, Ann Arbor, MI 48109-1065, USA.
Brixius-Anderko S; Department of Medicinal Chemistry, University of Michigan, 428 Church Street, Ann Arbor, MI 48109-1065, USA.
Scott EE; Department of Medicinal Chemistry, University of Michigan, 428 Church Street, Ann Arbor, MI 48109-1065, USA.; Department of Pharmacology, University of Michigan, 428 Church Street, Ann Arbor, MI 48109-1065, USA.
Olsen L; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.; Protein Engineering, Novozymes A/S, Krogshøjvej 36, DK-2880 Bagsvaerd, Denmark.
Jørgensen FS; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Björkling F; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Jul 09; Vol. 21 (14). Date of Electronic Publication: 2020 Jul 09.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Prostatic Neoplasms/*drug therapy
Steroid 17-alpha-Hydroxylase/*antagonists & inhibitors
Androgens/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; Male ; PC-3 Cells ; Prostatic Neoplasms/metabolism

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Skocz do pozycji: 19.

Tytuł:: CYP17A1 deficient XY mice display susceptibility to atherosclerosis, altered lipidomic profile and atypical sex development.
Autorzy:: Aherrahrou R; Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany.; Centre for Public Health Genomics, Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
Kulle AE; Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.
Alenina N; Max-Delbrück-Center for Molecular Medicine (MDC), Robert-Rössle-Str. 10, 13125, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.
Werner R; Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, University of Lübeck, Lübeck, Germany.; Institute of Molecular Medicine, University of Lübeck, Lübeck, Germany.
Vens-Cappell S; Bioanalytical Core Facility, CBBM (Center of Brain Behavior and Metabolism), University of Lübeck, Lübeck, Germany.
Bader M; Max-Delbrück-Center for Molecular Medicine (MDC), Robert-Rössle-Str. 10, 13125, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Charité-Universitätsmedizin, Berlin, Germany.; Institute for Biology, University of Lübeck, Lübeck, Germany.
Schunkert H; Kardiologie, Deutsches Herzzentrum München, Technische Universität München and DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Erdmann J; Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Germany, University Heart Centre Lübeck, 23562, Lübeck, Germany.
Aherrahrou Z; Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany. .; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Germany, University Heart Centre Lübeck, 23562, Lübeck, Germany. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 May 29; Vol. 10 (1), pp. 8792. Date of Electronic Publication: 2020 May 29.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Atherosclerosis/*genetics
Infertility/*genetics
Lipidomics/*methods
Steroid 17-alpha-Hydroxylase/*genetics
Steroids/*blood
Animals ; Atherosclerosis/blood ; Atherosclerosis/chemically induced ; Chromatography, Liquid ; Diet, Western/adverse effects ; Disease Models, Animal ; Female ; Infertility/blood ; Male ; Mass Spectrometry ; Mice ; Mice, Knockout ; Phenotype

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Skocz do pozycji: 20.

Tytuł:: Delayed Diagnosis of a 17-Hydroxylase/17,20-Lyase Deficient Patient Presenting as a 46,XY Female: A Low Normal Potassium Level Can Be an Alerting Diagnostic Sign.
Autorzy:: Çamtosun E; Ankara University Faculty of Medicine, Department of Pediatric Endocrinology, Ankara, Turkey, E-mail: .
Şıklar Z
Ceylaner S
Kocaay P
Berberoğlu M; Pokaż więcej
Źródło:: Journal of clinical research in pediatric endocrinology [J Clin Res Pediatr Endocrinol] 2017 Jun 01; Vol. 9 (2), pp. 163-167. Date of Electronic Publication: 2016 Dec 23.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Delayed Diagnosis*
Gonadal Dysgenesis, 46,XY*
Adrenal Hyperplasia, Congenital/*diagnosis
Potassium/*blood
Steroid 17-alpha-Hydroxylase/*metabolism
Adrenal Hyperplasia, Congenital/blood ; Adrenal Hyperplasia, Congenital/genetics ; Child, Preschool ; Diagnosis, Differential ; Disorders of Sex Development/blood ; Disorders of Sex Development/diagnosis ; Disorders of Sex Development/genetics ; Female ; Follicle Stimulating Hormone/blood ; Humans ; Luteinizing Hormone/blood ; Steroid 17-alpha-Hydroxylase/genetics
SCR Disease Name:: 46, XY female

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