Temat: "Steroid 17-alpha-Hydroxylase" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: The Multienzyme Complex Nature of Dehydroepiandrosterone Sulfate Biosynthesis.
Autorzy:: Tumilovich A; Institute of Bioorganic Chemistry NASB, 5 Building 2, V.F. Kuprevich Street, 220141 Minsk, Belarus.
Yablokov E; Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.
Mezentsev Y; Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.
Ershov P; Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.
Basina V; Research Centre for Medical Genetics, 1 Moskvorechye Street, 115522 Moscow, Russia.
Gnedenko O; Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.
Kaluzhskiy L; Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.
Tsybruk T; Institute of Bioorganic Chemistry NASB, 5 Building 2, V.F. Kuprevich Street, 220141 Minsk, Belarus.
Grabovec I; Institute of Bioorganic Chemistry NASB, 5 Building 2, V.F. Kuprevich Street, 220141 Minsk, Belarus.
Kisel M; Institute of Bioorganic Chemistry NASB, 5 Building 2, V.F. Kuprevich Street, 220141 Minsk, Belarus.
Shabunya P; Institute of Bioorganic Chemistry NASB, 5 Building 2, V.F. Kuprevich Street, 220141 Minsk, Belarus.
Soloveva N; Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.
Vavilov N; Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.
Gilep A; Institute of Bioorganic Chemistry NASB, 5 Building 2, V.F. Kuprevich Street, 220141 Minsk, Belarus.; Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.
Ivanov A; Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 08; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 08.
Typ publikacji:: Journal Article
MeSH Terms:: Multienzyme Complexes*/metabolism
Steroid 17-alpha-Hydroxylase*/metabolism
Dehydroepiandrosterone Sulfate ; Oxidation-Reduction ; Steroids ; Surface Plasmon Resonance ; Sulfotransferases/genetics ; Sulfotransferases/metabolism

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Skocz do pozycji: 2.

Tytuł:: Full-term live birth in a woman with 17α-hydroxylase and 17,20-lyase deficiency with assisted reproductive technology: a case report.
Autorzy:: Xi S; Peking University First Hospital Obstetric and Gynecology Department Reproductive and Genetic Center, No.1 Xi'an Men Street, Xi Cheng District, Beijing, China.
Yang X; Peking University First Hospital Obstetric and Gynecology Department Reproductive and Genetic Center, No.1 Xi'an Men Street, Xi Cheng District, Beijing, China.
Shan X; Peking University First Hospital Obstetric and Gynecology Department Reproductive and Genetic Center, No.1 Xi'an Men Street, Xi Cheng District, Beijing, China.
Xue Q; Peking University First Hospital Obstetric and Gynecology Department Reproductive and Genetic Center, No.1 Xi'an Men Street, Xi Cheng District, Beijing, China. .; Pokaż więcej
Źródło:: BMC women's health [BMC Womens Health] 2023 Aug 04; Vol. 23 (1), pp. 408. Date of Electronic Publication: 2023 Aug 04.
Typ publikacji:: Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Steroid 17-alpha-Hydroxylase*/genetics
Live Birth*
Humans ; Female ; Pregnancy ; Adult ; Progesterone ; Mixed Function Oxygenases ; Cesarean Section ; Dexamethasone

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Skocz do pozycji: 3.

Tytuł:: Exploring the Chemical Space of CYP17A1 Inhibitors Using Cheminformatics and Machine Learning.
Autorzy:: Yu T; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong (Shenzhen), Shenzhen 518172, China.; Center of Data Mining and Biomedical informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
Huang T; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong (Shenzhen), Shenzhen 518172, China.
Yu L; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai 200438, China.
Nantasenamat C; Streamlit Open Source, Snowflake Inc., San Mateo, CA 94402, USA.
Anuwongcharoen N; Center of Data Mining and Biomedical informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
Piacham T; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
Ren R; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai 200438, China.; Shanghai Qi Zhi Institute, Shanghai 200030, China.
Chiang YC; Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong (Shenzhen), Shenzhen 518172, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Feb 09; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 09.
Typ publikacji:: Journal Article
MeSH Terms:: Cheminformatics*
Enzyme Inhibitors*/pharmacology
Steroid 17-alpha-Hydroxylase*/antagonists & inhibitors
Dehydroepiandrosterone ; Machine Learning ; Quantitative Structure-Activity Relationship ; Steroids/chemistry

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Skocz do pozycji: 4.

Tytuł:: A novel homozygous CYP17A1 mutation causes partial 17 α-hydroxylase/17,20-lyase deficiency in 46,XX: a case report and literature review.
Autorzy:: Chen H; Department of Endocrinology and Metabolism, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Chen Y; Department of Endocrinology and Metabolism, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Mao H; Department of Endocrinology and Metabolism, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Huang H; Department of Endocrinology and Metabolism, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Lou X; Department of Endocrinology and Metabolism, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.; Pokaż więcej
Źródło:: Blood pressure [Blood Press] 2023 Dec; Vol. 32 (1), pp. 2195008.
Typ publikacji:: Review; Case Reports; Journal Article
MeSH Terms:: Hypokalemia*
Hypertension*/genetics
Female ; Humans ; Adult ; Steroid 17-alpha-Hydroxylase/genetics ; Progesterone ; Amenorrhea/genetics ; Mutation, Missense

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Skocz do pozycji: 5.

Tytuł:: Congenital adrenal hyperplasia disorder due to 17 α-hydroxylase deficiency: a case report.
Autorzy:: Tian Y; Department of Endocrinology and Metabolic, The First Hospital of Lanzhou University, Lanzhou, Gansu, P.R.China.
Hou L; Department of Endocrinology and Metabolic, The First Hospital of Lanzhou University, Lanzhou, Gansu, P.R.China.
Xiang S; Department of General Family Medicine, The First Hospital of Lanzhou University, Lanzhou, Gansu, P.R.China.
Tian X; Lintao Country People's Hospital, Lintao, Dingxi, Gansu, P.R.China.
Xu J; Department of Respiratory medicine, The First Hospital of Lanzhou University, Lanzhou, Gansu, P.R.China.; Pokaż więcej
Źródło:: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2023 Aug 18; Vol. 39 (1), pp. 2250001.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Adrenal Hyperplasia, Congenital*/complications
Adrenal Hyperplasia, Congenital*/diagnosis
Adrenal Hyperplasia, Congenital*/drug therapy
Female ; Humans ; Young Adult ; Adult ; Steroid 17-alpha-Hydroxylase/genetics ; Adrenocorticotropic Hormone ; Estradiol
SCR Disease Name:: Adrenal hyperplasia, congenital, type 5

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Skocz do pozycji: 6.

Tytuł:: Synthesis and Structure-Activity Relationships of Novel Non-Steroidal CYP17A1 Inhibitors as Potential Prostate Cancer Agents.
Autorzy:: Wróbel TM; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.; Department of Synthesis and Chemical Technology of Pharmaceutical Substances, Medical University of Lublin, Chodźki 4a, 20093 Lublin, Poland.
Rogova O; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Sharma K; Division of Pediatric Endocrinology, Department of Pediatrics, University Children's Hospital Bern, 3010 Bern, Switzerland.; Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland.
Rojas Velazquez MN; Division of Pediatric Endocrinology, Department of Pediatrics, University Children's Hospital Bern, 3010 Bern, Switzerland.; Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland.
Pandey AV; Division of Pediatric Endocrinology, Department of Pediatrics, University Children's Hospital Bern, 3010 Bern, Switzerland.; Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland.
Jørgensen FS; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Arendrup FS; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen, Denmark.
Andersen KL; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen, Denmark.
Björkling F; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2022 Jan 20; Vol. 12 (2). Date of Electronic Publication: 2022 Jan 20.
Typ publikacji:: Journal Article
MeSH Terms:: Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/pharmacology
Prostatic Neoplasms*/drug therapy
Prostatic Neoplasms*/enzymology
Steroid 17-alpha-Hydroxylase*/antagonists & inhibitors
Humans ; Male ; PC-3 Cells ; Structure-Activity Relationship

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Skocz do pozycji: 7.

Tytuł:: Mutated CYP17A1 promotes atherosclerosis and early-onset coronary artery disease.
Autorzy:: Wu TT; Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, People's Republic of China.
Zheng YY; Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, People's Republic of China.
Ma X; Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, People's Republic of China.
Xiu WJ; Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, People's Republic of China.
Yang HT; Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, People's Republic of China.
Hou XG; Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, People's Republic of China.
Yang Y; Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, People's Republic of China.
Chen Y; Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, People's Republic of China.
Ma YT; Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, People's Republic of China. myt_.
Xie X; Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, People's Republic of China. .; Pokaż więcej
Źródło:: Cell communication and signaling : CCS [Cell Commun Signal] 2023 Jun 27; Vol. 21 (1), pp. 155. Date of Electronic Publication: 2023 Jun 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms:: Atherosclerosis*/genetics
Coronary Artery Disease*/genetics
Animals ; Humans ; Mice ; Mice, Knockout ; Mice, Knockout, ApoE ; Signal Transduction ; Steroid 17-alpha-Hydroxylase/genetics

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Skocz do pozycji: 8.

Tytuł:: Endocrine profiles and cycle characteristics of infertile 17α-hydroxylase/17,20-lyase Deficiency Patients undergoing assisted Reproduction Treatment: a retrospective cohort study.
Autorzy:: Pan P; Reproductive Medicine Centre, Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, 510120, Guangdong, China.
Zheng L; Reproductive Medicine Centre, Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, 510120, Guangdong, China.
Huang J; Reproductive Medicine Centre, Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, 510120, Guangdong, China.
Chen X; Reproductive Medicine Centre, Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, 510120, Guangdong, China.
Ni R; Department of Reproductive Medicine, Kunming Angel Women's and Children's Hospital, Kunming, Yunnan, China.
Zhang Q; Reproductive Medicine Centre, Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, 510120, Guangdong, China.
Yang D; Reproductive Medicine Centre, Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, 510120, Guangdong, China. .
Li Y; Reproductive Medicine Centre, Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, 510120, Guangdong, China. .; Pokaż więcej
Źródło:: Journal of ovarian research [J Ovarian Res] 2023 Jun 14; Vol. 16 (1), pp. 111. Date of Electronic Publication: 2023 Jun 14.
Typ publikacji:: Journal Article
MeSH Terms:: Infertility, Female*/genetics
Infertility, Female*/therapy
Adrenal Hyperplasia, Congenital*/genetics
Pregnancy ; Humans ; Female ; Steroid 17-alpha-Hydroxylase/genetics ; Retrospective Studies ; Mixed Function Oxygenases

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Skocz do pozycji: 9.

Tytuł:: P450 CYP17A1 Variant with a Disordered Proton Shuttle Assembly Retains Peroxo-Mediated Lyase Efficiency.
Autorzy:: Liu Y; Department of Chemistry, Marquette University, 1414W Clybourn Street, Milwaukee, WI, 53233, USA.
Denisov IG; Departments of Biochemistry and Chemistry, University of Illinois, 116 Morrill Hall, 505 S. Goodwin Avenue, Urbana, IL, 61801, USA.
Grinkova YV; Departments of Biochemistry and Chemistry, University of Illinois, 116 Morrill Hall, 505 S. Goodwin Avenue, Urbana, IL, 61801, USA.
Sligar SG; Departments of Biochemistry and Chemistry, University of Illinois, 116 Morrill Hall, 505 S. Goodwin Avenue, Urbana, IL, 61801, USA.
Kincaid JR; Department of Chemistry, Marquette University, 1414W Clybourn Street, Milwaukee, WI, 53233, USA.; Pokaż więcej
Źródło:: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Dec 15; Vol. 26 (70), pp. 16846-16852. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji:: Journal Article
MeSH Terms:: Protons*
Lyases/*genetics
Lyases/*metabolism
Steroid 17-alpha-Hydroxylase/*genetics
Steroid 17-alpha-Hydroxylase/*metabolism
Humans ; Lyases/chemistry ; Pregnenolone ; Progesterone ; Steroid 17-alpha-Hydroxylase/chemistry

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Skocz do pozycji: 10.

Tytuł:: Functional Analysis of Steroidogenic Factor 1 (sf-1) and 17α-Hydroxylase/Lyase (cyp17α) Promoters in Yellow Catfish Pelteobagrus fulvidraco .
Autorzy:: Lv WH; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Chen GH; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Zhuo MQ; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Xu YH; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Xu YC; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Tan XY; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Dec 27; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 27.
Typ publikacji:: Journal Article
MeSH Terms:: Promoter Regions, Genetic*
Catfishes/*genetics
Gene Expression Regulation/*genetics
Steroid 17-alpha-Hydroxylase/*genetics
Steroidogenic Factor 1/*genetics
Animals ; Binding Sites ; Catfishes/metabolism ; Cloning, Molecular ; Genes, Reporter ; HEK293 Cells ; Humans ; Leptin/metabolism ; Luciferases/metabolism ; Mutation ; PPAR alpha/genetics ; PPAR alpha/metabolism ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Protein Binding ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Steroid 17-alpha-Hydroxylase/metabolism ; Steroidogenic Factor 1/metabolism ; Up-Regulation

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