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Wyszukujesz frazę ""Steroid Hydroxylases"" wg kryterium: Temat


Tytuł :
The Influence of Tobacco Smoke/Nicotine on CYP2A Expression in Human and African Green Monkey Lungs.
Autorzy :
Gao Y; Department of Pharmacology and Toxicology, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) (Y.G., S.M., R.F.T.) and Department of Psychiatry (R.F.T.), University of Toronto, Toronto, Ontario, Canada and Department of Psychiatry and Human Genetics, McGill University, Montreal, Quebec, Canada (R.M.P.).
Miksys S; Department of Pharmacology and Toxicology, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) (Y.G., S.M., R.F.T.) and Department of Psychiatry (R.F.T.), University of Toronto, Toronto, Ontario, Canada and Department of Psychiatry and Human Genetics, McGill University, Montreal, Quebec, Canada (R.M.P.).
Palmour RM; Department of Pharmacology and Toxicology, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) (Y.G., S.M., R.F.T.) and Department of Psychiatry (R.F.T.), University of Toronto, Toronto, Ontario, Canada and Department of Psychiatry and Human Genetics, McGill University, Montreal, Quebec, Canada (R.M.P.).
Tyndale RF; Department of Pharmacology and Toxicology, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) (Y.G., S.M., R.F.T.) and Department of Psychiatry (R.F.T.), University of Toronto, Toronto, Ontario, Canada and Department of Psychiatry and Human Genetics, McGill University, Montreal, Quebec, Canada (R.M.P.) .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2020 Dec; Vol. 98 (6), pp. 658-668. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aryl Hydrocarbon Hydroxylases/*metabolism
Lung/*pathology
Smoking/*pathology
Steroid Hydroxylases/*metabolism
Tobacco Smoke Pollution/*adverse effects
Animals ; Aryl Hydrocarbon Hydroxylases/analysis ; Aryl Hydrocarbon Hydroxylases/genetics ; Chlorocebus aethiops ; Datasets as Topic ; Disease Models, Animal ; Gene Expression Profiling ; Humans ; Lung/drug effects ; Lung Neoplasms/etiology ; Lung Neoplasms/pathology ; Lung Neoplasms/prevention & control ; Male ; Microsomes, Liver ; Nicotine/toxicity ; Non-Smokers ; RNA, Messenger/analysis ; Sequence Analysis, RNA ; Smoke/adverse effects ; Smokers ; Smoking/adverse effects ; Steroid Hydroxylases/analysis ; Steroid Hydroxylases/genetics ; Tobacco/chemistry ; Tobacco/toxicity
Czasopismo naukowe
Tytuł :
Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.
Autorzy :
Nail AN; Department of Microbiology, Immunology and Molecular Genetics, USA.
Spear BT; Department of Microbiology, Immunology and Molecular Genetics, USA; Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Peterson ML; Department of Microbiology, Immunology and Molecular Genetics, USA; Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY 40536, USA. Electronic address: .
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Źródło :
Gene [Gene] 2021 Jan 30; Vol. 767, pp. 145162. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article
MeSH Terms :
Aryl Hydrocarbon Hydroxylases/*genetics
Cytochrome P450 Family 2/*genetics
Liver/*metabolism
Steroid Hydroxylases/*genetics
Animals ; Aryl Hydrocarbon Hydroxylases/metabolism ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P450 Family 2/metabolism ; Female ; Gene Expression Regulation/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Protein Binding ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Messenger/genetics ; Steroid Hydroxylases/metabolism
Czasopismo naukowe
Tytuł :
Cholesterol 25-hydroxylase protects against experimental colitis in mice by modulating epithelial gut barrier function.
Autorzy :
Sheng N; The State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, 210061, China. .
Ma Z; The State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, 210061, China.
Zhou Y; State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Xu J; Deparment of Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, 210004, China.
Gao Y; The State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, 210061, China.
Fu XY; The State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, 210061, China. .; State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. .
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Źródło :
Scientific reports [Sci Rep] 2020 Aug 28; Vol. 10 (1), pp. 14246. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colitis/*drug therapy
Intestinal Mucosa/*drug effects
Steroid Hydroxylases/*pharmacology
Animals ; Caco-2 Cells ; Colitis/chemically induced ; Colitis/physiopathology ; Colitis, Ulcerative/pathology ; Colon/metabolism ; Colonic Neoplasms/pathology ; Cytokines/metabolism ; Dextran Sulfate/pharmacology ; Disease Models, Animal ; Epithelial Cells/metabolism ; Gastrointestinal Microbiome/drug effects ; HCT116 Cells ; Humans ; Intestinal Mucosa/metabolism ; Intestines/microbiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Permeability/drug effects ; Steroid Hydroxylases/metabolism ; Tight Junction Proteins/metabolism ; Tight Junctions/metabolism
Czasopismo naukowe
Tytuł :
Orphan Nuclear Receptor RORα Regulates Enzymatic Metabolism of Cerebral 24S-Hydroxycholesterol through CYP39A1 Intronic Response Element Activation.
Autorzy :
Matsuoka H; Laboratory of Genome Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
Katayama M; Laboratory of Genome Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
Ohishi A; Laboratory of Genome Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
Miya K; Laboratory of Genome Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
Tokunaga R; Laboratory of Genome Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
Kobayashi S; Laboratory of Genome Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
Nishimoto Y; Laboratory of Genome Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
Hirooka K; Department of Biotechnology, Faculty of Life Science and Biotechnology, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
Shima A; Laboratory of Genome Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
Michihara A; Laboratory of Genome Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 May 07; Vol. 21 (9). Date of Electronic Publication: 2020 May 07.
Typ publikacji :
Journal Article
MeSH Terms :
Brain/*metabolism
Hydroxycholesterols/*metabolism
Nuclear Receptor Subfamily 1, Group F, Member 1/*metabolism
Steroid Hydroxylases/*genetics
Gene Expression Regulation ; HEK293 Cells ; Hep G2 Cells ; Humans ; Hydroxycholesterols/blood ; Introns ; Nuclear Receptor Subfamily 1, Group F, Member 1/genetics ; Response Elements ; Steroid Hydroxylases/chemistry ; Steroid Hydroxylases/metabolism
Czasopismo naukowe
Tytuł :
Effects of available phosphorus source and concentration on performance and expression of sodium phosphate type IIb cotransporter, vitamin D-1α-hydroxylase, and vitamin D-24-hydroxylase mRNA in broiler chicks.
Autorzy :
Omara II; Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA 24060, USA; Animal Production Department, Faculty of Agriculture, Cairo University, Giza 12613, Egypt.
Mou CT; Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA 24060, USA.
Persia ME; Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA 24060, USA.
Wong EA; Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA 24060, USA. Electronic address: .
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Źródło :
Poultry science [Poult Sci] 2020 Apr; Vol. 99 (4), pp. 1822-1831. Date of Electronic Publication: 2020 Feb 28.
Typ publikacji :
Journal Article
MeSH Terms :
Avian Proteins/*genetics
Chickens/*genetics
Phosphorus, Dietary/*metabolism
Sodium-Phosphate Cotransporter Proteins, Type IIb/*genetics
Steroid Hydroxylases/*genetics
Vitamin D3 24-Hydroxylase/*genetics
Animal Feed/analysis ; Animals ; Avian Proteins/metabolism ; Biological Availability ; Calcium Phosphates/administration & dosage ; Calcium Phosphates/pharmacokinetics ; Chickens/growth & development ; Diet/veterinary ; Dietary Supplements/analysis ; Dose-Response Relationship, Drug ; Duodenum/metabolism ; Kidney/metabolism ; Nanoparticles/administration & dosage ; Nanoparticles/metabolism ; Phosphorus, Dietary/administration & dosage ; Phosphorus, Dietary/pharmacokinetics ; RNA, Messenger/metabolism ; Random Allocation ; Sodium-Phosphate Cotransporter Proteins, Type IIb/metabolism ; Steroid Hydroxylases/metabolism ; Vitamin D3 24-Hydroxylase/metabolism
Czasopismo naukowe
Tytuł :
Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.
Autorzy :
Honda A; Joint Research Center, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan .; Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Miyazaki T; Joint Research Center, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Iwamoto J; Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Hirayama T; Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Morishita Y; Diagnostic Pathology Division, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Monma T; Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Ueda H; Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Mizuno S; Laboratory Animal Resource Center, University of Tsukuba, Ibaraki, Japan.
Sugiyama F; Laboratory Animal Resource Center, University of Tsukuba, Ibaraki, Japan.
Takahashi S; Laboratory Animal Resource Center, University of Tsukuba, Ibaraki, Japan.
Ikegami T; Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
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Źródło :
Journal of lipid research [J Lipid Res] 2020 Jan; Vol. 61 (1), pp. 54-69. Date of Electronic Publication: 2019 Oct 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Aryl Hydrocarbon Hydroxylases/*genetics
Bile Acids and Salts/*metabolism
Cytochrome P-450 Enzyme System/*genetics
Steroid Hydroxylases/*genetics
Animals ; Aryl Hydrocarbon Hydroxylases/deficiency ; Aryl Hydrocarbon Hydroxylases/metabolism ; Bile Acids and Salts/chemistry ; Chenodeoxycholic Acid/chemistry ; Chenodeoxycholic Acid/metabolism ; Cytochrome P-450 Enzyme System/deficiency ; Cytochrome P-450 Enzyme System/metabolism ; Female ; Hydrophobic and Hydrophilic Interactions ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Structure ; Rats ; Rats, Sprague-Dawley ; Steroid Hydroxylases/deficiency ; Steroid Hydroxylases/metabolism
Czasopismo naukowe
Tytuł :
Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization.
Autorzy :
Martinez SE; Comparative Pharmacogenomics Laboratory, Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America. .
Andresen MC; Comparative Pharmacogenomics Laboratory, Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America.
Zhu Z; Comparative Pharmacogenomics Laboratory, Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America.
Papageorgiou I; Comparative Pharmacogenomics Laboratory, Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America.; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, Diabetes Institute, University of Florida, Gainesville, Florida, United States of America.
Court MH; Comparative Pharmacogenomics Laboratory, Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America.
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Źródło :
Scientific reports [Sci Rep] 2020 Jan 09; Vol. 10 (1), pp. 69. Date of Electronic Publication: 2020 Jan 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Variation*
Aryl Hydrocarbon Hydroxylases/*metabolism
Cytochrome P450 Family 2/*metabolism
Pharmacogenetics/*methods
Steroid Hydroxylases/*metabolism
3' Untranslated Regions ; Alleles ; Anesthetics, Intravenous/metabolism ; Animals ; Aryl Hydrocarbon Hydroxylases/genetics ; Breeding ; Cytochrome P450 Family 2/genetics ; Dogs ; Gene Frequency ; Haplotypes ; Linkage Disequilibrium ; Liver/enzymology ; Liver/metabolism ; Microsomes, Liver/metabolism ; Propofol/metabolism ; RNA Splicing ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/isolation & purification ; Steroid Hydroxylases/genetics
Czasopismo naukowe
Tytuł :
Cholesterol 25-hydroxylase suppresses rabies virus infection by inhibiting viral entry.
Autorzy :
Yuan Y; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, Huazhong Agricultural University, Wuhan, 430070, China.; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.; Department of Pathology, University of Georgia, Athens, GA, 30602, USA.
Wang Z; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, Huazhong Agricultural University, Wuhan, 430070, China.; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.; Department of Pathology, University of Georgia, Athens, GA, 30602, USA.
Tian B; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, Huazhong Agricultural University, Wuhan, 430070, China.; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.; Department of Pathology, University of Georgia, Athens, GA, 30602, USA.
Zhou M; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, Huazhong Agricultural University, Wuhan, 430070, China.; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.; Department of Pathology, University of Georgia, Athens, GA, 30602, USA.
Fu ZF; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, Huazhong Agricultural University, Wuhan, 430070, China.; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.; Department of Pathology, University of Georgia, Athens, GA, 30602, USA.
Zhao L; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China. .; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, Huazhong Agricultural University, Wuhan, 430070, China. .; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China. .; Department of Pathology, University of Georgia, Athens, GA, 30602, USA. .
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Źródło :
Archives of virology [Arch Virol] 2019 Dec; Vol. 164 (12), pp. 2963-2974. Date of Electronic Publication: 2019 Sep 24.
Typ publikacji :
Journal Article
MeSH Terms :
Virus Internalization*
Rabies/*enzymology
Rabies virus/*physiology
Steroid Hydroxylases/*metabolism
Animals ; Cell Line ; Host-Pathogen Interactions ; Humans ; Hydroxycholesterols/metabolism ; Mice ; Rabies/genetics ; Rabies/virology ; Rabies virus/genetics ; Steroid Hydroxylases/genetics ; Virus Replication
Czasopismo naukowe
Tytuł :
Sterol metabolism modulates susceptibility to HIV-1 Infection.
Autorzy :
Saulle I; Department of Biomedical and Clinical Sciences 'L. Sacco'.; Department of Pathophysiology and Transplantation, University of Milan, Milan.
Ibba SV; Department of Biomedical and Clinical Sciences 'L. Sacco'.
Vittori C; Department of Biomedical and Clinical Sciences 'L. Sacco'.
Fenizia C; Department of Pathophysiology and Transplantation, University of Milan, Milan.
Mercurio V; Department of Biomedical and Clinical Sciences 'L. Sacco'.
Vichi F; S. Maria Annunziata Hospital, Florence.
Caputo SL; Dipartimento di Medicina Clinica e Sperimentale, Università di Foggia.
Trabattoni D; Department of Biomedical and Clinical Sciences 'L. Sacco'.
Clerici M; Department of Pathophysiology and Transplantation, University of Milan, Milan.; Don C. Gnocchi Foundation ONLUS, IRCCS, Milan, Italy.
Biasin M; Department of Biomedical and Clinical Sciences 'L. Sacco'.
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Źródło :
AIDS (London, England) [AIDS] 2020 Sep 01; Vol. 34 (11), pp. 1593-1602.
Typ publikacji :
Journal Article
MeSH Terms :
HIV Infections/*transmission
HIV Seronegativity/*genetics
HIV Seronegativity/*physiology
MicroRNAs/*blood
Sterols/*metabolism
HIV-1 ; Humans ; Hydroxycholesterols ; Immunity, Innate ; Leukocytes, Mononuclear ; Real-Time Polymerase Chain Reaction ; Steroid Hydroxylases/genetics ; Steroid Hydroxylases/metabolism ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł :
IL-1β/TNF-α/IL-6 inflammatory cytokines promote STAT1-dependent induction of CH25H in Zika virus-infected human macrophages.
Autorzy :
Magoro T; HIV/AIDS and Global Health Research Program, Department of Microbiology, University of Venda, Thohoyandou, Limpopo, South Africa.; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908.; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908.
Dandekar A; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908.; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908.
Jennelle LT; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908.; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908.
Bajaj R; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908.; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908.
Lipkowitz G; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908.; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908.
Angelucci AR; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908.; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908.
Bessong PO; HIV/AIDS and Global Health Research Program, Department of Microbiology, University of Venda, Thohoyandou, Limpopo, South Africa.
Hahn YS; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908 .; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 Oct 04; Vol. 294 (40), pp. 14591-14602. Date of Electronic Publication: 2019 Aug 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Activating Transcription Factor 3/*genetics
STAT1 Transcription Factor/*genetics
Steroid Hydroxylases/*genetics
Zika Virus/*genetics
Zika Virus Infection/*genetics
Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Cytokines/genetics ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; Gene Expression Regulation, Enzymologic ; Humans ; Inflammation/enzymology ; Inflammation/genetics ; Inflammation/virology ; Interferon Type I/genetics ; Interleukin-1beta/genetics ; Interleukin-6/genetics ; Macrophages/virology ; Steroid Hydroxylases/chemistry ; Toll-Like Receptors/genetics ; Tumor Necrosis Factor-alpha/genetics ; Virus Replication/genetics ; Zika Virus/pathogenicity ; Zika Virus Infection/enzymology ; Zika Virus Infection/virology
Czasopismo naukowe
Tytuł :
Ligand-binding properties and catalytic activity of the purified human 24-hydroxycholesterol 7α-hydroxylase, CYP39A1.
Autorzy :
Grabovec IP; Institute of Bioorganic Chemistry NAS of Belarus, Minsk, Belarus.
Smolskaya SV; Sechenov First Moscow State Medical University, Moscow, Russia.
Baranovsky AV; Institute of Bioorganic Chemistry NAS of Belarus, Minsk, Belarus.
Zhabinskii VN; Institute of Bioorganic Chemistry NAS of Belarus, Minsk, Belarus.
Dichenko YV; Institute of Bioorganic Chemistry NAS of Belarus, Minsk, Belarus.
Shabunya PS; Institute of Bioorganic Chemistry NAS of Belarus, Minsk, Belarus.
Usanov SA; Institute of Bioorganic Chemistry NAS of Belarus, Minsk, Belarus.
Strushkevich NV; Institute of Bioorganic Chemistry NAS of Belarus, Minsk, Belarus. Electronic address: .
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Źródło :
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2019 Oct; Vol. 193, pp. 105416. Date of Electronic Publication: 2019 Jun 24.
Typ publikacji :
Journal Article
MeSH Terms :
Azoles/*metabolism
Estrone/*metabolism
Steroid Hydroxylases/*metabolism
Sterols/*metabolism
Catalysis ; Escherichia coli/genetics ; Humans ; Ligands ; Recombinant Proteins/metabolism ; Steroid Hydroxylases/genetics
Czasopismo naukowe
Tytuł :
Porcine Reproductive and Respiratory Syndrome Virus E Protein Degrades Porcine Cholesterol 25-Hydroxylase via the Ubiquitin-Proteasome Pathway.
Autorzy :
Ke W; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; The Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Fang L; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China .; The Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Tao R; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; The Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Li Y; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; The Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Jing H; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; The Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Wang D; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; The Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Xiao S; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China .; The Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
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Źródło :
Journal of virology [J Virol] 2019 Sep 30; Vol. 93 (20). Date of Electronic Publication: 2019 Sep 30 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Porcine Reproductive and Respiratory Syndrome/*metabolism
Porcine Reproductive and Respiratory Syndrome/*virology
Porcine respiratory and reproductive syndrome virus/*physiology
Proteasome Endopeptidase Complex/*metabolism
Steroid Hydroxylases/*metabolism
Ubiquitin/*metabolism
Viral Envelope Proteins/*metabolism
Amino Acid Sequence ; Animals ; Gene Expression Regulation, Viral ; Gene Knockdown Techniques ; Host-Pathogen Interactions ; Protein Binding ; Signal Transduction ; Steroid Hydroxylases/genetics ; Swine ; Ubiquitination ; Viral Envelope Proteins/chemistry
Czasopismo naukowe
Tytuł :
The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis.
Autorzy :
Raselli T; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
Wyss A; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
Gonzalez Alvarado MN; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
Weder B; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
Mamie C; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
Spalinger MR; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
Van Haaften WT; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Dijkstra G; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Sailer AW; Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research, Basel, Switzerland.
Imenez Silva PH; Institute of Physiology, Zurich University, Zurich, Switzerland.
Wagner CA; Institute of Physiology, Zurich University, Zurich, Switzerland.
Tosevski V; Mass Cytometry Facility, Zurich University, Zurich, Switzerland.
Leibl S; Institute of Pathology and Molecular Pathology, University Hospital Zurich and Zurich University, Zurich, Switzerland.
Scharl M; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
Rogler G; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
Hausmann M; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
Misselwitz B; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
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Źródło :
Journal of Crohn's & colitis [J Crohns Colitis] 2019 Sep 19; Vol. 13 (9), pp. 1186-1200.
Typ publikacji :
Journal Article
MeSH Terms :
Intestines/*pathology
Oxysterols/*metabolism
Steroid Hydroxylases/*metabolism
Adult ; Aged ; Aged, 80 and over ; Animals ; Colitis/chemically induced ; Colitis/enzymology ; Crohn Disease/complications ; Crohn Disease/pathology ; Dextran Sulfate/pharmacology ; Disease Models, Animal ; Female ; Fibrosis ; Humans ; Intestines/enzymology ; Intestines/transplantation ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; Steroid Hydroxylases/deficiency
Czasopismo naukowe
Tytuł :
Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol.
Autorzy :
Wang S; Division of Genetics, Department of Pediatrics, Institute for Genomic Medicine, Program in Immunology, University of California San Diego, La Jolla, CA, USA.
Li W; Division of Genetics, Department of Pediatrics, Institute for Genomic Medicine, Program in Immunology, University of California San Diego, La Jolla, CA, USA.; Department of Biology, University of California San Diego, La Jolla, CA, USA.
Hui H; Division of Genetics, Department of Pediatrics, Institute for Genomic Medicine, Program in Immunology, University of California San Diego, La Jolla, CA, USA.; Department of Biology, University of California San Diego, La Jolla, CA, USA.; Bioinformatics Program, University of California San Diego, La Jolla, CA, USA.
Tiwari SK; Division of Genetics, Department of Pediatrics, Institute for Genomic Medicine, Program in Immunology, University of California San Diego, La Jolla, CA, USA.
Zhang Q; Division of Genetics, Department of Pediatrics, Institute for Genomic Medicine, Program in Immunology, University of California San Diego, La Jolla, CA, USA.
Croker BA; Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Rawlings S; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Smith D; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Carlin AF; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Rana TM; Division of Genetics, Department of Pediatrics, Institute for Genomic Medicine, Program in Immunology, University of California San Diego, La Jolla, CA, USA.
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Źródło :
The EMBO journal [EMBO J] 2020 Nov 02; Vol. 39 (21), pp. e106057. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Betacoronavirus/*drug effects
Cholesterol/*metabolism
Coronavirus Infections/*drug therapy
Pneumonia, Viral/*drug therapy
Respiratory Mucosa/*virology
Steroid Hydroxylases/*pharmacology
Virus Internalization/*drug effects
Acetyl-CoA C-Acetyltransferase/metabolism ; Animals ; COVID-19 ; Cell Line ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Chlorocebus aethiops ; Enzyme Activation/drug effects ; Humans ; Middle East Respiratory Syndrome Coronavirus/drug effects ; Organoids/virology ; Pandemics ; Respiratory Mucosa/drug effects ; SARS Virus/drug effects ; SARS-CoV-2 ; Vero Cells
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Cholesterol 24S-Hydroxylase overexpression increases the lipid droplet formation of human umbilical cord mesenchymal stem cells but does not affect adipocyte differentiation.
Autorzy :
Jiang Y; Department of Neurosurgery, Zhengzhou Central Hospital affiliated Zhengzhou University, Zhengzhou, China.
Zhang WJ; Department of Neurosurgery, Zhengzhou Central Hospital affiliated Zhengzhou University, Zhengzhou, China.
Liang AM; Department of Neurosurgery, Zhengzhou Central Hospital affiliated Zhengzhou University, Zhengzhou, China.
Lv GW; Department of Neurosurgery, Zhengzhou Central Hospital affiliated Zhengzhou University, Zhengzhou, China.
Ma BD; Center of Stem Cell and Regenerative Medicine, Zhengzhou Central Hospital affiliated Zhengzhou University, Zhengzhou, China.
Yue H; Center of Stem Cell and Regenerative Medicine, Zhengzhou Central Hospital affiliated Zhengzhou University, Zhengzhou, China.
Sun L; Center of Stem Cell and Regenerative Medicine, Zhengzhou Central Hospital affiliated Zhengzhou University, Zhengzhou, China.
Zhang H; Department of Neurosurgery, Zhengzhou Central Hospital affiliated Zhengzhou University, Zhengzhou, China.
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Źródło :
Journal of biological regulators and homeostatic agents [J Biol Regul Homeost Agents] 2020 Nov-Dec; Vol. 34 (6), pp. 2029-2036.
Typ publikacji :
Journal Article
MeSH Terms :
Mesenchymal Stem Cells*
Adipocytes ; Cell Differentiation ; Cholesterol ; Humans ; Lipid Droplets ; Osteogenesis ; Steroid Hydroxylases ; Umbilical Cord
Czasopismo naukowe
Tytuł :
Distinct Regioselectivity of Fungal P450 Enzymes for Steroidal Hydroxylation.
Autorzy :
Lu W; National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Center for Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.; University of Chinese Academy of Sciences, Beijing, China.
Feng J; National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Center for Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China .
Chen X; National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Center for Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Bao YJ; National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Center for Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Wang Y; National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Center for Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Wu Q; National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Center for Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Ma Y; National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Center for Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Zhu D; National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Center for Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China .; University of Chinese Academy of Sciences, Beijing, China.
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Źródło :
Applied and environmental microbiology [Appl Environ Microbiol] 2019 Aug 29; Vol. 85 (18). Date of Electronic Publication: 2019 Aug 29 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytochrome P-450 Enzyme System/*chemistry
Fungal Proteins/*chemistry
Rhizoctonia/*enzymology
Steroid Hydroxylases/*chemistry
Biotransformation ; Cytochrome P-450 Enzyme System/metabolism ; Fungal Proteins/metabolism ; Hydroxylation ; Steroid Hydroxylases/metabolism ; Steroids/metabolism ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis.
Autorzy :
Heintz MM; Environmental Toxicology Program, Clemson University, Clemson, SC 29634.
Kumar R; Biological Sciences, Clemson University, Clemson, SC 29634.
Rutledge MM; Environmental Toxicology Program, Clemson University, Clemson, SC 29634.
Baldwin WS; Environmental Toxicology Program, Clemson University, Clemson, SC 29634; Biological Sciences, Clemson University, Clemson, SC 29634. Electronic address: .
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Źródło :
The Journal of nutritional biochemistry [J Nutr Biochem] 2019 Aug; Vol. 70, pp. 125-137. Date of Electronic Publication: 2019 May 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Lipid Metabolism*
Aryl Hydrocarbon Hydroxylases/*genetics
Cytochrome P450 Family 2/*genetics
Obesity/*genetics
Steroid Hydroxylases/*genetics
Adipose Tissue, White/metabolism ; Animals ; Aryl Hydrocarbon Hydroxylases/metabolism ; Base Sequence ; Body Weight ; Cluster Analysis ; Cytochrome P450 Family 2/metabolism ; Diet, High-Fat ; Fatty Acids/metabolism ; Female ; Glucose Tolerance Test ; Homeostasis ; Male ; Mice ; Mice, Inbred C57BL ; Obesity/metabolism ; Sex Factors ; Steroid Hydroxylases/metabolism ; Triglycerides/metabolism
Czasopismo naukowe
Tytuł :
Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins.
Autorzy :
Zhou QD; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Surgical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, P.R. China.
Chi X; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Lee MS; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.
Hsieh WY; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Mkrtchyan JJ; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Feng AC; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
He C; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
York AG; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Yale University, New Haven, CT, USA.
Bui VL; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Kronenberger EB; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Ferrari A; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Xiao X; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Daly AE; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Tarling EJ; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Damoiseaux R; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.
Scumpia PO; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Smale ST; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Williams KJ; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Tontonoz P; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Bensinger SJ; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA. .; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA. .
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Źródło :
Nature immunology [Nat Immunol] 2020 Jul; Vol. 21 (7), pp. 746-755. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Infections/*immunology
Bacterial Toxins/*immunology
Hydroxycholesterols/*metabolism
Interferons/*isolation & purification
Phagocytes/*immunology
Streptolysins/*immunology
Animals ; Bacteria/immunology ; Bacteria/metabolism ; Bacterial Proteins/administration & dosage ; Bacterial Proteins/immunology ; Bacterial Proteins/metabolism ; Bacterial Toxins/metabolism ; Cell Membrane/metabolism ; Cell Membrane Permeability/immunology ; Cells, Cultured ; Disease Models, Animal ; Disease Susceptibility/immunology ; Female ; Host Microbial Interactions/immunology ; Humans ; Intravital Microscopy ; Male ; Mice ; Mice, Transgenic ; Phagocytes/cytology ; Phagocytes/metabolism ; Primary Cell Culture ; Steroid Hydroxylases/genetics ; Steroid Hydroxylases/metabolism ; Streptolysins/administration & dosage ; Streptolysins/metabolism
Czasopismo naukowe
Tytuł :
Characterization of two steroid hydroxylases from different Streptomyces spp. and their ligand-bound and -unbound crystal structures.
Autorzy :
Dangi B; Department of Life Science and Biochemical Engineering, Sunmoon University, Asansi, Korea.
Lee CW; Unit of Polar Genomics, Korea Polar Research Institute, Incheon, Korea.; Department of Polar Sciences, University of Science and Technology, Incheon, Korea.
Kim KH; Department of Life Science and Biochemical Engineering, Sunmoon University, Asansi, Korea.
Park SH; Unit of Polar Genomics, Korea Polar Research Institute, Incheon, Korea.
Yu EJ; Department of Life Science and Biochemical Engineering, Sunmoon University, Asansi, Korea.
Jeong CS; Unit of Polar Genomics, Korea Polar Research Institute, Incheon, Korea.; Department of Polar Sciences, University of Science and Technology, Incheon, Korea.
Park H; Unit of Polar Genomics, Korea Polar Research Institute, Incheon, Korea.; Department of Polar Sciences, University of Science and Technology, Incheon, Korea.
Lee JH; Unit of Polar Genomics, Korea Polar Research Institute, Incheon, Korea.; Department of Polar Sciences, University of Science and Technology, Incheon, Korea.
Oh TJ; Department of Life Science and Biochemical Engineering, Sunmoon University, Asansi, Korea.; Genome-based BioIT Convergence Institute, Asansi, Korea.; Department of Pharmaceutical Engineering and Biotechnology, Sunmoon University, Asansi, Korea.
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Źródło :
The FEBS journal [FEBS J] 2019 May; Vol. 286 (9), pp. 1683-1699. Date of Electronic Publication: 2018 Dec 31.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*chemistry
Steroid Hydroxylases/*chemistry
Streptomyces/*enzymology
Amino Acid Sequence ; Androstenedione/metabolism ; Bacterial Proteins/metabolism ; Catalytic Domain ; Chromatography, High Pressure Liquid ; Conserved Sequence ; Crystallography, X-Ray ; Ligands ; Models, Molecular ; Nuclear Magnetic Resonance, Biomolecular ; Progesterone/metabolism ; Protein Binding ; Protein Conformation ; Recombinant Proteins/chemistry ; Sequence Alignment ; Sequence Homology, Amino Acid ; Steroid Hydroxylases/metabolism ; Testosterone/metabolism
Czasopismo naukowe
Tytuł :
Mining for Oxysterols in Cyp7b1 Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5.
Autorzy :
Meljon A; Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK. .; Institute for Global Food Security, Queens University Belfast, Stranmillis Road, Belfast BT9 5AG, UK. .
Crick PJ; Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK. .
Yutuc E; Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK. .
Yau JL; Endocrinology Unit, BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. .
Seckl JR; Endocrinology Unit, BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. .
Theofilopoulos S; Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK. .; Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden. .
Arenas E; Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden. .
Wang Y; Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK. .
Griffiths WJ; Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK. .
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Źródło :
Biomolecules [Biomolecules] 2019 Apr 13; Vol. 9 (4). Date of Electronic Publication: 2019 Apr 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*metabolism
Cytochrome P450 Family 7/*genetics
Hydroxycholesterols/*metabolism
Spastic Paraplegia, Hereditary/*metabolism
Steroid Hydroxylases/*genetics
Animals ; Cytochrome P450 Family 7/deficiency ; Hydroxycholesterols/blood ; Male ; Mice ; Spastic Paraplegia, Hereditary/blood ; Spastic Paraplegia, Hereditary/genetics ; Steroid Hydroxylases/deficiency
Czasopismo naukowe

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