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Tytuł:
An Unexpected Enzyme in Vascular Smooth Muscle Cells: Angiotensin II Upregulates Cholesterol-25-Hydroxylase Gene Expression.
Autorzy:
Kovács KB; Department of Physiology, Semmelweis University, 1094 Budapest, Hungary.
Szalai L; Department of Physiology, Semmelweis University, 1094 Budapest, Hungary.; ELKH-SE Laboratory of Molecular Physiology, Eötvös Loránd Research Network and Semmelweis University, 1085 Budapest, Hungary.
Szabó P; Research Center for Natural Sciences, Center for Structural Study, MS Metabolomics Laboratory, 1117 Budapest, Hungary.
Gém JB; Department of Physiology, Semmelweis University, 1094 Budapest, Hungary.
Barsi S; Department of Physiology, Semmelweis University, 1094 Budapest, Hungary.
Szalai B; Department of Physiology, Semmelweis University, 1094 Budapest, Hungary.; Research Centre for Natural Sciences, Institute of Enzymology, 1117 Budapest, Hungary.
Perey-Simon B; Department of Physiology, Semmelweis University, 1094 Budapest, Hungary.
Turu G; Department of Physiology, Semmelweis University, 1094 Budapest, Hungary.; ELKH-SE Laboratory of Molecular Physiology, Eötvös Loránd Research Network and Semmelweis University, 1085 Budapest, Hungary.
Tóth AD; Department of Physiology, Semmelweis University, 1094 Budapest, Hungary.; ELKH-SE Laboratory of Molecular Physiology, Eötvös Loránd Research Network and Semmelweis University, 1085 Budapest, Hungary.; Department of Internal Medicine and Haematology, Semmelweis University, 1088 Budapest, Hungary.
Várnai P; Department of Physiology, Semmelweis University, 1094 Budapest, Hungary.; ELKH-SE Laboratory of Molecular Physiology, Eötvös Loránd Research Network and Semmelweis University, 1085 Budapest, Hungary.
Hunyady L; Department of Physiology, Semmelweis University, 1094 Budapest, Hungary.; ELKH-SE Laboratory of Molecular Physiology, Eötvös Loránd Research Network and Semmelweis University, 1085 Budapest, Hungary.; Research Centre for Natural Sciences, Institute of Enzymology, 1117 Budapest, Hungary.
Balla A; Department of Physiology, Semmelweis University, 1094 Budapest, Hungary.; ELKH-SE Laboratory of Molecular Physiology, Eötvös Loránd Research Network and Semmelweis University, 1085 Budapest, Hungary.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 16; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
Angiotensin II*/metabolism
Muscle, Smooth, Vascular*/enzymology
Steroid Hydroxylases*/genetics
Animals ; Rats ; Cells, Cultured ; Chromatography, Liquid ; Gene Expression ; Myocytes, Smooth Muscle/metabolism ; Tandem Mass Spectrometry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Role of Cholesterol 25-Hydroxylase (Ch25h) in Mediating Innate Immune Responses to Streptococcus pneumoniae Infection.
Autorzy:
Cho SJ; Weill Cornell Medicine, New York, NY 10021, USA.
Pronko A; Weill Cornell Medicine, New York, NY 10021, USA.
Yang J; Weill Cornell Medicine, New York, NY 10021, USA.
Pagan K; Weill Cornell Medicine, New York, NY 10021, USA.
Stout-Delgado H; Weill Cornell Medicine, New York, NY 10021, USA.
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Źródło:
Cells [Cells] 2023 Feb 10; Vol. 12 (4). Date of Electronic Publication: 2023 Feb 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Lung*/metabolism
Pneumococcal Infections*
Steroid Hydroxylases*
Animals ; Mice ; Cytokines/metabolism ; Immunity, Innate ; Streptococcus pneumoniae/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In Silico Prediction of the Metabolic Resistance of Vitamin D Analogs against CYP3A4 Metabolizing Enzyme.
Autorzy:
Żołek T; Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha, 02-097 Warsaw, Poland.
Yasuda K; Department of Pharmaceutical Engineering, Toyama Prefectural University, Toyama 939-0398, Japan.
Brown G; School of Biomedical Sciences, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Sakaki T; Department of Pharmaceutical Engineering, Toyama Prefectural University, Toyama 939-0398, Japan.
Kutner A; Department of Bioanalysis and Drug Analysis, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha, 02-097 Warsaw, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jul 16; Vol. 23 (14). Date of Electronic Publication: 2022 Jul 16.
Typ publikacji:
Journal Article
MeSH Terms:
Steroid Hydroxylases*/metabolism
Vitamin D*/metabolism
Cytochrome P-450 CYP3A ; Cytochrome P-450 Enzyme System/metabolism ; Humans ; Vitamin D3 24-Hydroxylase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Placenta-A New Source of Bile Acids during Healthy Pregnancy? First Results of a Gene Expression Study in Humans and Mice.
Autorzy:
Ontsouka E; Faculty of Medicine, Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.
Schroeder M; Faculty of Medicine, Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.
Ok L; Institut National de la Recherche Scientifique (INRS), Centre Armand Frappier et Regroupement Intersectoriel de Recherche en Santé de l'Université du Quebec (RISUQ), 532 des Prairies, Laval, QC H7V1B7, Canada.
Vaillancourt C; Institut National de la Recherche Scientifique (INRS), Centre Armand Frappier et Regroupement Intersectoriel de Recherche en Santé de l'Université du Quebec (RISUQ), 532 des Prairies, Laval, QC H7V1B7, Canada.
Stroka D; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Murtenstrasse 35, 3002 Bern, Switzerland.
Albrecht C; Faculty of Medicine, Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 30; Vol. 24 (11). Date of Electronic Publication: 2023 May 30.
Typ publikacji:
Journal Article
MeSH Terms:
Bile Acids and Salts*/metabolism
Steroid 12-alpha-Hydroxylase*/genetics
Humans ; Mice ; Animals ; Pregnancy ; Female ; Liver/metabolism ; Cholesterol/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Placenta/metabolism ; Gene Expression ; Steroid Hydroxylases/genetics ; Steroid Hydroxylases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tumor Necrosis Factor-alpha utilizes MAPK/NFκB pathways to induce cholesterol-25 hydroxylase for amplifying pro-inflammatory response via 25-hydroxycholesterol-integrin-FAK pathway.
Autorzy:
Pokharel SM; Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America.
Chiok K; Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America.
Shil NK; Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America.
Mohanty I; Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America.
Bose S; Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America.
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Źródło:
PloS one [PLoS One] 2021 Sep 22; Vol. 16 (9), pp. e0257576. Date of Electronic Publication: 2021 Sep 22 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Signal Transduction/*drug effects
Steroid Hydroxylases/*metabolism
Tumor Necrosis Factor-alpha/*pharmacology
Activating Transcription Factor 2/metabolism ; Animals ; Cells, Cultured ; Chemokine CCL3/metabolism ; Female ; Focal Adhesion Protein-Tyrosine Kinases/antagonists & inhibitors ; Focal Adhesion Protein-Tyrosine Kinases/metabolism ; Humans ; Hydroxycholesterols/metabolism ; Integrin alpha5/metabolism ; Macrophages/cytology ; Macrophages/drug effects ; Macrophages/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitogen-Activated Protein Kinases/metabolism ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/metabolism ; Protein Binding ; Steroid Hydroxylases/deficiency ; Steroid Hydroxylases/genetics ; Up-Regulation/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Oxysterol 7-α Hydroxylase (CYP7B1) Attenuates Metabolic-Associated Fatty Liver Disease in Mice at Thermoneutrality.
Autorzy:
Evangelakos I; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Schwinge D; Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Worthmann A; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
John C; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Roeder N; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Pertzborn P; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Behrens J; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Schramm C; Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Scheja L; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Heeren J; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
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Źródło:
Cells [Cells] 2021 Oct 05; Vol. 10 (10). Date of Electronic Publication: 2021 Oct 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Temperature*
Cytochrome P450 Family 7/*metabolism
Fatty Liver/*enzymology
Fatty Liver/*metabolism
Steroid Hydroxylases/*metabolism
Animals ; Biomarkers/metabolism ; Cytochrome P450 Family 7/deficiency ; Inflammation/pathology ; Lipid Metabolism ; Liver/metabolism ; Liver/pathology ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Mice ; Mice, Knockout ; Phenotype ; Receptors, Lipoprotein/metabolism ; Spleen/immunology ; Steroid Hydroxylases/deficiency ; Up-Regulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Revisiting Steroidogenic Pathways in the Human Placenta and Primary Human Trophoblast Cells.
Autorzy:
Karahoda R; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Akademika Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.
Kallol S; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.; Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, 3012 Bern, Switzerland.
Groessl M; Department of Nephrology and Hypertension, Department of Biomedical Research, Inselspital, University of Bern, Freiburgstrasse 15, 3010 Bern, Switzerland.
Ontsouka E; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.
Anderle P; Sitem Center for Translational Medicine and Biomedical Entrepreneurship and Sitem-Insel AG, University of Bern, Freiburgstrasse 3, 3010 Bern, Switzerland.
Fluck C; Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Department of Biomedical Research, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 15, 3010 Bern, Switzerland.
Staud F; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Akademika Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.
Albrecht C; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.; Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, 3012 Bern, Switzerland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 08; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 08.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation*
Choriocarcinoma/*metabolism
Placenta/*metabolism
Pregnancy Trimester, First/*metabolism
Steroid Hydroxylases/*metabolism
Steroids/*metabolism
Trophoblasts/*metabolism
Adult ; Cells, Cultured ; Choriocarcinoma/pathology ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Placenta/cytology ; Pregnancy ; Steroid Hydroxylases/genetics ; Trophoblasts/cytology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Orphan Nuclear Receptor RORα Regulates Enzymatic Metabolism of Cerebral 24S-Hydroxycholesterol through CYP39A1 Intronic Response Element Activation.
Autorzy:
Matsuoka H; Laboratory of Genome Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
Katayama M; Laboratory of Genome Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
Ohishi A; Laboratory of Genome Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
Miya K; Laboratory of Genome Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
Tokunaga R; Laboratory of Genome Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
Kobayashi S; Laboratory of Genome Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
Nishimoto Y; Laboratory of Genome Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
Hirooka K; Department of Biotechnology, Faculty of Life Science and Biotechnology, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
Shima A; Laboratory of Genome Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
Michihara A; Laboratory of Genome Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 May 07; Vol. 21 (9). Date of Electronic Publication: 2020 May 07.
Typ publikacji:
Journal Article
MeSH Terms:
Brain/*metabolism
Hydroxycholesterols/*metabolism
Nuclear Receptor Subfamily 1, Group F, Member 1/*metabolism
Steroid Hydroxylases/*genetics
Gene Expression Regulation ; HEK293 Cells ; Hep G2 Cells ; Humans ; Hydroxycholesterols/blood ; Introns ; Nuclear Receptor Subfamily 1, Group F, Member 1/genetics ; Response Elements ; Steroid Hydroxylases/chemistry ; Steroid Hydroxylases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cholesterol 25-hydroxylase protects against experimental colitis in mice by modulating epithelial gut barrier function.
Autorzy:
Sheng N; The State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, 210061, China. .
Ma Z; The State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, 210061, China.
Zhou Y; State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Xu J; Deparment of Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, 210004, China.
Gao Y; The State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, 210061, China.
Fu XY; The State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, 210061, China. .; State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. .
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Źródło:
Scientific reports [Sci Rep] 2020 Aug 28; Vol. 10 (1), pp. 14246. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Colitis/*drug therapy
Intestinal Mucosa/*drug effects
Steroid Hydroxylases/*pharmacology
Animals ; Caco-2 Cells ; Colitis/chemically induced ; Colitis/physiopathology ; Colitis, Ulcerative/pathology ; Colon/metabolism ; Colonic Neoplasms/pathology ; Cytokines/metabolism ; Dextran Sulfate/pharmacology ; Disease Models, Animal ; Epithelial Cells/metabolism ; Gastrointestinal Microbiome/drug effects ; HCT116 Cells ; Humans ; Intestinal Mucosa/metabolism ; Intestines/microbiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Permeability/drug effects ; Steroid Hydroxylases/metabolism ; Tight Junction Proteins/metabolism ; Tight Junctions/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner.
Autorzy:
Wong MY; Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Lewis M; Sage Therapeutics, Cambridge, Massachusetts, USA.
Doherty JJ; Sage Therapeutics, Cambridge, Massachusetts, USA.
Shi Y; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Cashikar AG; Departments of Neurology and Psychiatry, Hope Center for Neurological Disorders, Taylor Family Institute, Washington University School of Medicine, St. Louis, MO, USA.
Amelianchik A; Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Tymchuk S; Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Sullivan PM; Department of Medicine, Duke University Medical Center, Durham Veterans Health Administration Medical Center's Geriatric Research, Education and Clinical Center, Durham, NC, USA.
Qian M; Departments of Developmental Biology, Anesthesiology, Taylor Family Institute for Innovative Psychiatric Research, Washington University in St. Louis, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Covey DF; Departments of Developmental Biology, Anesthesiology, Taylor Family Institute for Innovative Psychiatric Research, Washington University in St. Louis, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Petsko GA; Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Holtzman DM; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Paul SM; Sage Therapeutics, Cambridge, Massachusetts, USA. .; Departments of Neurology and Psychiatry, Hope Center for Neurological Disorders, Taylor Family Institute, Washington University School of Medicine, St. Louis, MO, USA. .
Luo W; Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2020 Jun 17; Vol. 17 (1), pp. 192. Date of Electronic Publication: 2020 Jun 17.
Typ publikacji:
Journal Article
MeSH Terms:
Apolipoproteins E/*metabolism
Hydroxycholesterols/*metabolism
Interleukin-1beta/*metabolism
Microglia/*metabolism
Steroid Hydroxylases/*metabolism
Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Animals ; Apolipoproteins E/genetics ; Frontal Lobe/drug effects ; Frontal Lobe/metabolism ; Humans ; Lipopolysaccharides/pharmacology ; Mice ; Mice, Transgenic ; Microglia/drug effects ; Steroid Hydroxylases/genetics ; tau Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization.
Autorzy:
Martinez SE; Comparative Pharmacogenomics Laboratory, Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America. s_.
Andresen MC; Comparative Pharmacogenomics Laboratory, Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America.
Zhu Z; Comparative Pharmacogenomics Laboratory, Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America.
Papageorgiou I; Comparative Pharmacogenomics Laboratory, Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America.; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, Diabetes Institute, University of Florida, Gainesville, Florida, United States of America.
Court MH; Comparative Pharmacogenomics Laboratory, Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America.
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Źródło:
Scientific reports [Sci Rep] 2020 Jan 09; Vol. 10 (1), pp. 69. Date of Electronic Publication: 2020 Jan 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Variation*
Aryl Hydrocarbon Hydroxylases/*metabolism
Cytochrome P450 Family 2/*metabolism
Pharmacogenetics/*methods
Steroid Hydroxylases/*metabolism
3' Untranslated Regions ; Alleles ; Anesthetics, Intravenous/metabolism ; Animals ; Aryl Hydrocarbon Hydroxylases/genetics ; Breeding ; Cytochrome P450 Family 2/genetics ; Dogs ; Gene Frequency ; Haplotypes ; Linkage Disequilibrium ; Liver/enzymology ; Liver/metabolism ; Microsomes, Liver/metabolism ; Propofol/metabolism ; RNA Splicing ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/isolation & purification ; Steroid Hydroxylases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis.
Autorzy:
Raselli T; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
Wyss A; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
Gonzalez Alvarado MN; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
Weder B; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
Mamie C; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
Spalinger MR; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
Van Haaften WT; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Dijkstra G; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Sailer AW; Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research, Basel, Switzerland.
Imenez Silva PH; Institute of Physiology, Zurich University, Zurich, Switzerland.
Wagner CA; Institute of Physiology, Zurich University, Zurich, Switzerland.
Tosevski V; Mass Cytometry Facility, Zurich University, Zurich, Switzerland.
Leibl S; Institute of Pathology and Molecular Pathology, University Hospital Zurich and Zurich University, Zurich, Switzerland.
Scharl M; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
Rogler G; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
Hausmann M; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
Misselwitz B; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.
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Źródło:
Journal of Crohn's & colitis [J Crohns Colitis] 2019 Sep 19; Vol. 13 (9), pp. 1186-1200.
Typ publikacji:
Journal Article
MeSH Terms:
Intestines/*pathology
Oxysterols/*metabolism
Steroid Hydroxylases/*metabolism
Adult ; Aged ; Aged, 80 and over ; Animals ; Colitis/chemically induced ; Colitis/enzymology ; Crohn Disease/complications ; Crohn Disease/pathology ; Dextran Sulfate/pharmacology ; Disease Models, Animal ; Female ; Fibrosis ; Humans ; Intestines/enzymology ; Intestines/transplantation ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; Steroid Hydroxylases/deficiency
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Characterization of two steroid hydroxylases from different Streptomyces spp. and their ligand-bound and -unbound crystal structures.
Autorzy:
Dangi B; Department of Life Science and Biochemical Engineering, Sunmoon University, Asansi, Korea.
Lee CW; Unit of Polar Genomics, Korea Polar Research Institute, Incheon, Korea.; Department of Polar Sciences, University of Science and Technology, Incheon, Korea.
Kim KH; Department of Life Science and Biochemical Engineering, Sunmoon University, Asansi, Korea.
Park SH; Unit of Polar Genomics, Korea Polar Research Institute, Incheon, Korea.
Yu EJ; Department of Life Science and Biochemical Engineering, Sunmoon University, Asansi, Korea.
Jeong CS; Unit of Polar Genomics, Korea Polar Research Institute, Incheon, Korea.; Department of Polar Sciences, University of Science and Technology, Incheon, Korea.
Park H; Unit of Polar Genomics, Korea Polar Research Institute, Incheon, Korea.; Department of Polar Sciences, University of Science and Technology, Incheon, Korea.
Lee JH; Unit of Polar Genomics, Korea Polar Research Institute, Incheon, Korea.; Department of Polar Sciences, University of Science and Technology, Incheon, Korea.
Oh TJ; Department of Life Science and Biochemical Engineering, Sunmoon University, Asansi, Korea.; Genome-based BioIT Convergence Institute, Asansi, Korea.; Department of Pharmaceutical Engineering and Biotechnology, Sunmoon University, Asansi, Korea.
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Źródło:
The FEBS journal [FEBS J] 2019 May; Vol. 286 (9), pp. 1683-1699. Date of Electronic Publication: 2018 Dec 31.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bacterial Proteins/*chemistry
Steroid Hydroxylases/*chemistry
Streptomyces/*enzymology
Amino Acid Sequence ; Androstenedione/metabolism ; Bacterial Proteins/metabolism ; Catalytic Domain ; Chromatography, High Pressure Liquid ; Conserved Sequence ; Crystallography, X-Ray ; Ligands ; Models, Molecular ; Nuclear Magnetic Resonance, Biomolecular ; Progesterone/metabolism ; Protein Binding ; Protein Conformation ; Recombinant Proteins/chemistry ; Sequence Alignment ; Sequence Homology, Amino Acid ; Steroid Hydroxylases/metabolism ; Testosterone/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mining for Oxysterols in Cyp7b1 Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5.
Autorzy:
Meljon A; Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK. .; Institute for Global Food Security, Queens University Belfast, Stranmillis Road, Belfast BT9 5AG, UK. .
Crick PJ; Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK. .
Yutuc E; Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK. .
Yau JL; Endocrinology Unit, BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. .
Seckl JR; Endocrinology Unit, BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. .
Theofilopoulos S; Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK. .; Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden. .
Arenas E; Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden. .
Wang Y; Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK. .
Griffiths WJ; Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK. .
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Źródło:
Biomolecules [Biomolecules] 2019 Apr 13; Vol. 9 (4). Date of Electronic Publication: 2019 Apr 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain/*metabolism
Cytochrome P450 Family 7/*genetics
Hydroxycholesterols/*metabolism
Spastic Paraplegia, Hereditary/*metabolism
Steroid Hydroxylases/*genetics
Animals ; Cytochrome P450 Family 7/deficiency ; Hydroxycholesterols/blood ; Male ; Mice ; Spastic Paraplegia, Hereditary/blood ; Spastic Paraplegia, Hereditary/genetics ; Steroid Hydroxylases/deficiency
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Interleukin-1 Induces the Release of Lubricating Phospholipids from Human Osteoarthritic Fibroblast-like Synoviocytes.
Autorzy:
Thottakkattumana Parameswaran V; Laboratory for Experimental Orthopaedics, Department of Orthopaedics, Justus Liebig University Giessen, 35392 Giessen, Germany.
Hild C; Laboratory for Experimental Orthopaedics, Department of Orthopaedics, Justus Liebig University Giessen, 35392 Giessen, Germany.
Eichner G; Mathematical Institute, Justus Liebig University Giessen, 35392 Giessen, Germany.
Ishaque B; Laboratory for Experimental Orthopaedics, Department of Orthopaedics, Justus Liebig University Giessen, 35392 Giessen, Germany.
Rickert M; Laboratory for Experimental Orthopaedics, Department of Orthopaedics, Justus Liebig University Giessen, 35392 Giessen, Germany.
Steinmeyer J; Laboratory for Experimental Orthopaedics, Department of Orthopaedics, Justus Liebig University Giessen, 35392 Giessen, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Feb 22; Vol. 23 (5). Date of Electronic Publication: 2022 Feb 22.
Typ publikacji:
Journal Article
MeSH Terms:
Benzoates/*pharmacology
Benzylamines/*pharmacology
Interleukin-1beta/*pharmacology
Osteoarthritis/*metabolism
Phospholipids/*metabolism
Synoviocytes/*cytology
ATP Binding Cassette Transporter 1/genetics ; Cells, Cultured ; Cytochrome P450 Family 7/genetics ; Gene Expression Regulation/drug effects ; Humans ; Liver X Receptors/genetics ; Osteoarthritis/genetics ; Steroid Hydroxylases/genetics ; Synovial Fluid/cytology ; Synovial Fluid/drug effects ; Synovial Fluid/metabolism ; Synoviocytes/drug effects ; Synoviocytes/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Transcriptomic Meta-Analysis Shows Lipid Metabolism Dysregulation as an Early Pathological Mechanism in the Spinal Cord of SOD1 Mice.
Autorzy:
Fernández-Beltrán LC; Neurological Disorders Group, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, Spain.
Godoy-Corchuelo JM; Neurological Disorders Group, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, Spain.
Losa-Fontangordo M; Neurological Disorders Group, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, Spain.
Williams D; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK.
Matias-Guiu J; Neurological Disorders Group, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, Spain.
Corrochano S; Neurological Disorders Group, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 02; Vol. 22 (17). Date of Electronic Publication: 2021 Sep 02.
Typ publikacji:
Journal Article; Meta-Analysis
MeSH Terms:
Lipid Metabolism*
Transcriptome*
Amyotrophic Lateral Sclerosis/*metabolism
Spinal Cord/*metabolism
Amyotrophic Lateral Sclerosis/etiology ; Animals ; Disease Models, Animal ; Female ; Mice ; Steroid Hydroxylases/genetics ; Steroid Hydroxylases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
NR1H4 rs35724 G>C variant modulates liver damage in nonalcoholic fatty liver disease.
Autorzy:
Grimaudo S; Sezione di Gastroenterologia e Epatologia, Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro', University of Palermo, Palermo, Italy.
Dongiovanni P; General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Pihlajamäki J; Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Eslam M; Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, Australia.
Yki-Järvinen H; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Pipitone RM; Sezione di Gastroenterologia e Epatologia, Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro', University of Palermo, Palermo, Italy.
Baselli G; Department of Pathophysiology and Transplantation, Section Internal Medicine, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico, Università degli Studi, Milano, Italy.
Cammà C; Sezione di Gastroenterologia e Epatologia, Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro', University of Palermo, Palermo, Italy.
Di Marco V; Sezione di Gastroenterologia e Epatologia, Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro', University of Palermo, Palermo, Italy.
Enea M; Sezione di Gastroenterologia e Epatologia, Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro', University of Palermo, Palermo, Italy.
Longo M; General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, Italy.
Pennisi G; Sezione di Gastroenterologia e Epatologia, Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro', University of Palermo, Palermo, Italy.
Prati D; Precision Medicine, Department of Transfusion Medicine and Hematology, Fondazione IRCCS Cà Granda Pad Marangoni, Milan, Italy.
Zito R; Sezione di Gastroenterologia e Epatologia, Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro', University of Palermo, Palermo, Italy.
Fracanzani AL; General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Pathophysiology and Transplantation, Section Internal Medicine, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico, Università degli Studi, Milano, Italy.
Craxì A; Sezione di Gastroenterologia e Epatologia, Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro', University of Palermo, Palermo, Italy.
George J; Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, Australia.
Romeo S; Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Valenti L; Department of Pathophysiology and Transplantation, Section Internal Medicine, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico, Università degli Studi, Milano, Italy.; Department of Pathophysiology and Transplantion, Università degli Studi, Milan, Italy.
Petta S; Sezione di Gastroenterologia e Epatologia, Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro', University of Palermo, Palermo, Italy.
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2021 Nov; Vol. 41 (11), pp. 2712-2719. Date of Electronic Publication: 2021 Jul 29.
Typ publikacji:
Journal Article
MeSH Terms:
Non-alcoholic Fatty Liver Disease*/genetics
Non-alcoholic Fatty Liver Disease*/pathology
Receptors, Cytoplasmic and Nuclear/*genetics
Bile Acids and Salts ; Humans ; Liver/pathology ; Liver Cirrhosis/genetics ; Liver Cirrhosis/pathology ; Receptor, Fibroblast Growth Factor, Type 4 ; Steroid Hydroxylases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Daikenchuto (TU-100) alters murine hepatic and intestinal drug metabolizing enzymes in an in vivo dietary model: effects of gender and withdrawal.
Autorzy:
Nobutani K; Department of Medicine, Knapp Center for Biomedical Center, The University of Chicago, Chicago, Illinois.
Miyoshi J; Department of Medicine, Knapp Center for Biomedical Center, The University of Chicago, Chicago, Illinois.
Musch MW; Department of Medicine, Knapp Center for Biomedical Center, The University of Chicago, Chicago, Illinois.
Nishiyama M; Tsumura Research Laboratories, Tsumura & Co., Ami, Ibaraki, Japan.
Watanabe J; Tsumura Research Laboratories, Tsumura & Co., Ami, Ibaraki, Japan.
Kaneko A; Tsumura Research Laboratories, Tsumura & Co., Ami, Ibaraki, Japan.
Yamamoto M; Tsumura Research Laboratories, Tsumura & Co., Ami, Ibaraki, Japan.
Yoshida M; Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Kono T; Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Hokkaido, Japan.; Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
Jeong H; Departments of Pharmacy Practice and Biopharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago, Illinois.
Chang EB; Department of Medicine, Knapp Center for Biomedical Center, The University of Chicago, Chicago, Illinois.
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Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2017 Oct; Vol. 5 (5).
Typ publikacji:
Journal Article
MeSH Terms:
ATP Binding Cassette Transporter, Subfamily B/*genetics
Aryl Hydrocarbon Hydroxylases/*genetics
Cytochrome P-450 CYP3A/*genetics
Cytochrome P450 Family 2/*genetics
Intestines/*enzymology
Liver/*enzymology
Membrane Proteins/*genetics
Plant Extracts/*adverse effects
Steroid Hydroxylases/*genetics
ATP Binding Cassette Transporter, Subfamily B/metabolism ; Animals ; Aryl Hydrocarbon Hydroxylases/metabolism ; Cytochrome P-450 CYP3A/metabolism ; Cytochrome P450 Family 2/metabolism ; Dietary Supplements/adverse effects ; Dose-Response Relationship, Drug ; Female ; Gene Expression Regulation, Enzymologic/drug effects ; Intestines/drug effects ; Liver/drug effects ; Male ; Membrane Proteins/metabolism ; Mice ; Models, Animal ; Panax ; Sex Factors ; Steroid Hydroxylases/metabolism ; Zanthoxylum ; Zingiberaceae
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification and characterization of the steroid 15α-hydroxylase gene from Penicillium raistrickii.
Autorzy:
Jia L; College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China.
Dong J; College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China.
Wang R; College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China.
Mao S; College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China.
Lu F; College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China. .
Singh S; Department of Biotechnology & Food Technology, Faculty of Applied Sciences, Durban University of Technology, P.O. Box 1334, Durban, 4001, South Africa.
Wang Z; College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin, 300457, China.
Liu X; College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin, 300457, China. liu_.
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Źródło:
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2017 Aug; Vol. 101 (16), pp. 6409-6418. Date of Electronic Publication: 2017 Jun 29.
Typ publikacji:
Journal Article
MeSH Terms:
Aryl Hydrocarbon Hydroxylases/*genetics
Penicillium/*enzymology
Penicillium/*genetics
Steroid Hydroxylases/*genetics
Aryl Hydrocarbon Hydroxylases/metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Gene Deletion ; Gene Expression Profiling ; Genes, Fungal ; Hydroxylation ; Norpregnenes/metabolism ; Open Reading Frames ; Penicillium/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Steroid Hydroxylases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null mice.
Autorzy:
Kumar R; Biological Sciences, Clemson University, Clemson, SC, United States of America.
Mota LC; Environmental Toxicology, Clemson University, Pendleton, SC, United States of America.
Litoff EJ; Biological Sciences, Clemson University, Clemson, SC, United States of America.
Rooney JP; NHEERL, US-EPA, Research Triangle Park, NC, United States of America.
Boswell WT; Biological Sciences, Clemson University, Clemson, SC, United States of America.
Courter E; Biological Sciences, Clemson University, Clemson, SC, United States of America.
Henderson CM; Biological Sciences, Clemson University, Clemson, SC, United States of America.
Hernandez JP; Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, United States of America.
Corton JC; NHEERL, US-EPA, Research Triangle Park, NC, United States of America.
Moore DD; Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, United States of America.
Baldwin WS; Biological Sciences, Clemson University, Clemson, SC, United States of America.; Environmental Toxicology, Clemson University, Pendleton, SC, United States of America.
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Źródło:
PloS one [PLoS One] 2017 Mar 28; Vol. 12 (3), pp. e0174355. Date of Electronic Publication: 2017 Mar 28 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Aryl Hydrocarbon Hydroxylases/*genetics
Cytochrome P-450 Enzyme System/*genetics
Cytochrome P450 Family 2/*genetics
Receptors, Cytoplasmic and Nuclear/*genetics
Steroid Hydroxylases/*genetics
Animals ; Aryl Hydrocarbon Hydroxylases/metabolism ; CRISPR-Cas Systems ; Constitutive Androstane Receptor ; Cytochrome P-450 CYP3A ; Cytochrome P-450 Enzyme System/metabolism ; Cytochrome P450 Family 2/metabolism ; Female ; Gene Deletion ; Gene Expression ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Pharmacological and Toxicological Phenomena ; Receptors, Cytoplasmic and Nuclear/metabolism ; Steroid Hydroxylases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice.
Autorzy:
Noebauer B; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Jais A; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Todoric J; Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, UCSD School of Medicine, San Diego, CA, USA.
Gossens K; Max Planck Institute for Immunobiology and Epigenetics, Freiburg, Germany.
Sutterlüty-Fall H; Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Einwallner E; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
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Źródło:
Journal of diabetes research [J Diabetes Res] 2017; Vol. 2017, pp. 4108768. Date of Electronic Publication: 2017 Feb 19.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2/*genetics
Insulin Resistance/*genetics
Liver/*metabolism
Obesity/*genetics
Steroid Hydroxylases/*genetics
Animals ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Disease Progression ; Male ; Mice ; Mice, Transgenic ; Obesity/metabolism ; Steroid Hydroxylases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Differences in expression of genes related to steroidgenesis in abdominal subcutaneous adipose tissue of pregnant women with and without PCOS; a case control study.
Autorzy:
Emami N; Department of Biology, Faculty of Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Moini A; Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.; Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran.; Department of Gynecology and Obstetrics, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Yaghmaei P; Department of Biology, Faculty of Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Akbarinejad V; Department of Theriogenology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Shahhoseini M; Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. .; Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. .; Department of Cell and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran. .
Alizadeh A; Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. .
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Źródło:
BMC pregnancy and childbirth [BMC Pregnancy Childbirth] 2021 Jul 07; Vol. 21 (1), pp. 490. Date of Electronic Publication: 2021 Jul 07.
Typ publikacji:
Journal Article
MeSH Terms:
Gonadal Steroid Hormones/*metabolism
Hydroxysteroid Dehydrogenases/*metabolism
Polycystic Ovary Syndrome/*genetics
Steroid Hydroxylases/*metabolism
Subcutaneous Fat, Abdominal/*metabolism
Adult ; Case-Control Studies ; Cesarean Section ; Female ; Gene Expression/genetics ; Glucocorticoids/metabolism ; Humans ; Mineralocorticoids/metabolism ; Phosphoproteins/metabolism ; Pregnancy ; RNA, Messenger/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Description of clinical features and genetic analysis of one ultra-rare (SPG64) and two common forms (SPG5A and SPG15) of hereditary spastic paraplegia families.
Autorzy:
Pashaei M; Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Davarzani A; Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Hajati R; Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Zamani B; Neurology Department, Firoozgar hospital, Iran University of Medical Sciences, Tehran, Iran.
Nafissi S; Department of Neurology, Shariati Hospital., Tehran University of Medical Sciences, Tehran, Iran.
Larti F; Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Nilipour Y; Pediatric Pathology Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Rohani M; Department of Neurology, Hazrat Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran.
Alavi A; Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
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Źródło:
Journal of neurogenetics [J Neurogenet] 2021 Mar-Jun; Vol. 35 (2), pp. 84-94. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Apyrase/*genetics
Carrier Proteins/*genetics
Cytochrome P450 Family 7/*genetics
Spastic Paraplegia, Hereditary/*genetics
Steroid Hydroxylases/*genetics
Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Humans ; Male ; Mutation ; Pedigree ; Phenotype ; Spastic Paraplegia, Hereditary/physiopathology ; Exome Sequencing ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Biotransformation of Cholesterol and 16α,17α-Epoxypregnenolone and Isolation of Hydroxylase in Burkholderia cepacia SE-1.
Autorzy:
Zhu X; College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang 330045, China.
Pang C; College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang 330045, China.
Cao Y; College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang 330045, China.
Fan D; College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang 330045, China.
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Źródło:
BioMed research international [Biomed Res Int] 2016; Vol. 2016, pp. 5727631. Date of Electronic Publication: 2016 Jun 02.
Typ publikacji:
Journal Article
MeSH Terms:
17-alpha-Hydroxypregnenolone/*metabolism
Burkholderia cepacia/*metabolism
Cholesterol/*metabolism
Steroid Hydroxylases/*biosynthesis
Steroid Hydroxylases/*chemistry
Biotransformation/physiology ; Burkholderia cepacia/classification ; Enzyme Activation ; Species Specificity ; Steroid Hydroxylases/isolation & purification
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Impaired cholesterol metabolism in the mouse model of cystic fibrosis. A preliminary study.
Autorzy:
Amato F; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, University of Naples Federico II, Naples, Italy.; CEINGE-Biotecnologie Avanzate, Scarl, Naples, Italy.
Castaldo A; Dipartimento di Scienze Mediche Traslazionali, University of Naples Federico II, Naples, Italy.
Castaldo G; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, University of Naples Federico II, Naples, Italy.; CEINGE-Biotecnologie Avanzate, Scarl, Naples, Italy.
Cernera G; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, University of Naples Federico II, Naples, Italy.; CEINGE-Biotecnologie Avanzate, Scarl, Naples, Italy.
Corso G; Dipartimento di Medicina Clinica e Sperimentale, University of Foggia, Foggia, Italy.
Ferrari E; European Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy.; Dipartimento di Scienze della Salute, University of Eastern Piedmont, Novara, Italy.
Gelzo M; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, University of Naples Federico II, Naples, Italy.; CEINGE-Biotecnologie Avanzate, Scarl, Naples, Italy.
Monzani R; European Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy.; Dipartimento di Scienze della Salute, University of Eastern Piedmont, Novara, Italy.
Villella VR; European Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy.
Raia V; Dipartimento di Scienze Mediche Traslazionali, University of Naples Federico II, Naples, Italy.
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Źródło:
PloS one [PLoS One] 2021 Jan 07; Vol. 16 (1), pp. e0245302. Date of Electronic Publication: 2021 Jan 07 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lipid Metabolism*
Mutation*
Cholesterol/*metabolism
Cystic Fibrosis/*pathology
Cystic Fibrosis Transmembrane Conductance Regulator/*genetics
Liver/*metabolism
Steroid Hydroxylases/*metabolism
Animals ; Cystic Fibrosis/genetics ; Cystic Fibrosis/metabolism ; Female ; Homozygote ; Male ; Metabolic Clearance Rate ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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