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Tytuł:
Pterostilbene Induces Apoptosis from Endoplasmic Reticulum Stress Synergistically with Anticancer Drugs That Deposit Iron in Mitochondria.
Autorzy:
Nishiguch Y; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Fujiwara-Tani R; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Nukaga S; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Nishida R; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Ikemoto A; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Sasaki R; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Mori S; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Ogata R; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Kishi S; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.; Pathology Laboratory, Research Institute, Tokushukai Nozaki Hospital, 2-10-50 Tanigawa, Daito 574-0074, Osaka, Japan.
Hojo Y; Department of Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Hyogo, Japan.
Shinohara H; Department of Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Hyogo, Japan.
Sho M; Department of Surgery, Nara Medical University, Kashihara 634-8522, Nara, Japan.
Kuniyasu H; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 23; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 23.
Typ publikacji:
Journal Article
MeSH Terms:
Stomach Neoplasms*/pathology
Antineoplastic Agents*/pharmacology
Stilbenes*/pharmacology
Humans ; Hydrogen Peroxide/metabolism ; Fluorouracil/pharmacology ; Reactive Oxygen Species/metabolism ; Cisplatin/pharmacology ; Doxorubicin/pharmacology ; Apoptosis ; Mitochondria/metabolism ; Endoplasmic Reticulum Stress ; Cell Line, Tumor ; Adaptor Proteins, Signal Transducing/metabolism
Czasopismo naukowe
Tytuł:
Synthesis, In Vitro, and In Vivo Investigations of Pterostilbene-Tethered Analogues as Anti-Breast Cancer Candidates.
Autorzy:
Li G; School of Pharmacy, Changzhou University, Changzhou 213164, China.
Li J; School of Pharmacy, Changzhou University, Changzhou 213164, China.; Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Analysis and Testing Center, NERC Biomass of Changzhou University, Changzhou 213164, China.
Wang W; School of Pharmacy, Changzhou University, Changzhou 213164, China.
Feng X; School of Pharmacy, Changzhou University, Changzhou 213164, China.
Yu X; School of Pharmacy, Changzhou University, Changzhou 213164, China.
Yuan S; School of Pharmacy, Changzhou University, Changzhou 213164, China.
Zhang W; School of Pharmacy, Changzhou University, Changzhou 213164, China.
Chen J; School of Pharmacy, Changzhou University, Changzhou 213164, China.
Hu C; School of Pharmacy, Changzhou University, Changzhou 213164, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 14; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 14.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*/metabolism
Stilbenes*/pharmacology
Stilbenes*/therapeutic use
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Antineoplastic Agents*/chemistry
Humans ; Animals ; Mice ; Female ; Cell Line, Tumor ; Apoptosis ; Cell Proliferation
Czasopismo naukowe
Tytuł:
Improvement of the Physicochemical Limitations of Rhapontigenin, a Cytotoxic Analogue of Resveratrol against Colon Cancer.
Autorzy:
Navarro-Orcajada S; Departamento de Bioquímica y Biología Molecular-A, Facultad de Biología, Universidad de Murcia-Regional Campus of International Excellence 'Campus Mare Nostrum', E-30100 Murcia, Spain.
Vidal-Sánchez FJ; Departamento de Bioquímica y Biología Molecular-A, Facultad de Biología, Universidad de Murcia-Regional Campus of International Excellence 'Campus Mare Nostrum', E-30100 Murcia, Spain.
Conesa I; Departamento de Bioquímica y Biología Molecular-A, Facultad de Biología, Universidad de Murcia-Regional Campus of International Excellence 'Campus Mare Nostrum', E-30100 Murcia, Spain.
Matencio A; Dipartimento di Chimica, Università di Torino, via P. Giuria 7, 10125 Turin, Italy.
López-Nicolás JM; Departamento de Bioquímica y Biología Molecular-A, Facultad de Biología, Universidad de Murcia-Regional Campus of International Excellence 'Campus Mare Nostrum', E-30100 Murcia, Spain.
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Źródło:
Biomolecules [Biomolecules] 2023 Aug 20; Vol. 13 (8). Date of Electronic Publication: 2023 Aug 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Colonic Neoplasms*/drug therapy
Stilbenes*/pharmacology
Antineoplastic Agents*/pharmacology
Cyclodextrins*
Humans ; Resveratrol/pharmacology
Czasopismo naukowe
Tytuł:
Systematic Studies on Anti-Cancer Evaluation of Stilbene and Dibenzo[ b,f ]oxepine Derivatives.
Autorzy:
Borys F; Department of Organic Chemistry, Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Poland.; Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.
Tobiasz P; Department of Organic Chemistry, Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Poland.
Poterała M; Department of Organic Chemistry, Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Poland.
Fabczak H; Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.
Krawczyk H; Department of Organic Chemistry, Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Poland.
Joachimiak E; Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Apr 18; Vol. 28 (8). Date of Electronic Publication: 2023 Apr 18.
Typ publikacji:
Journal Article
MeSH Terms:
Stilbenes*/chemistry
Neoplasms*/drug therapy
Neoplasms*/metabolism
Antineoplastic Agents*/chemistry
Humans ; Tubulin/metabolism ; Oxepins/metabolism ; HEK293 Cells ; Microtubules/metabolism ; Colchicine/chemistry ; Tubulin Modulators/chemistry ; Binding Sites ; Cell Proliferation
Czasopismo naukowe
Tytuł:
Development of Combretastatin A-4 Analogues as Potential Anticancer Agents with Improved Aqueous Solubility.
Autorzy:
Chen ZH; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China.
Xu RM; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China.
Zheng GH; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China.
Jin YZ; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China.
Li Y; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China.
Chen XY; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China.
Tian YS; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Feb 10; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 10.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Stilbenes*/chemistry
Cell Proliferation ; Drug Screening Assays, Antitumor ; Molecular Structure ; Solubility ; Structure-Activity Relationship ; Tubulin/metabolism ; Tubulin Modulators/pharmacology ; Humans ; Cell Line, Tumor
Czasopismo naukowe
Tytuł:
Design, synthesis, and biological evaluation of tetrahydroisoquinoline stilbene derivatives as potential antitumor candidates.
Autorzy:
Li B; Department of Chemistry, Bengbu Medical College, Bengbu, China.
Wang J; Department of Chemistry, Bengbu Medical College, Bengbu, China.
Yuan M; Department of Chemistry, Bengbu Medical College, Bengbu, China.
Miao Y; Department of Chemistry, Bengbu Medical College, Bengbu, China.
Zhang H; Department of Chemistry, Bengbu Medical College, Bengbu, China.
Zhang J; Department of Chemistry, Bengbu Medical College, Bengbu, China.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2023 Feb; Vol. 101 (2), pp. 364-379. Date of Electronic Publication: 2022 Sep 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Stilbenes*/pharmacology
Antineoplastic Agents*/pharmacology
Tetrahydroisoquinolines*/pharmacology
Humans ; Cell Line, Tumor ; Tubulin/metabolism ; Tubulin Modulators/pharmacology ; Apoptosis ; Drug Screening Assays, Antitumor ; Cell Proliferation ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Mechanism of Resveratrol-Induced Programmed Cell Death and New Drug Discovery against Cancer: A Review.
Autorzy:
Jang JY; Department of Pharmacy, College of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Korea.
Im E; Department of Pharmacy, College of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Korea.
Kim ND; Department of Pharmacy, College of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Nov 08; Vol. 23 (22). Date of Electronic Publication: 2022 Nov 08.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neoplasms*/drug therapy
Stilbenes*/pharmacology
Stilbenes*/therapeutic use
Stilbenes*/chemistry
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Humans ; Resveratrol/pharmacology ; Apoptosis ; Drug Discovery
Czasopismo naukowe
Tytuł:
Cytotoxic and Antioxidant Activities of Imine Analogs of Trans-Resveratrol towards Murine Neuronal N2a Cells.
Autorzy:
Ksila M; Team 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA7270/Inserm, University Bourgogne Franche-Comté, 21000 Dijon, France.; Laboratory of Neurophysiology, Cellular Physiopathology and Valorisation of Biomolecules, (LR18ES03), Department of Biology, Faculty of Sciences, University Tunis El Manar, Tunis 2092, Tunisia.
Vejux A; Team 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA7270/Inserm, University Bourgogne Franche-Comté, 21000 Dijon, France.
Prost-Camus E; Laboratoire Spiral, 21560 Couternon, France.
Durand P; Laboratoire Spiral, 21560 Couternon, France.
Ghzaiel I; Team 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA7270/Inserm, University Bourgogne Franche-Comté, 21000 Dijon, France.; Institut Européen des Antioxydants (IEA), 1B, rue Victor de Lespinats, 54230 Neuves-Maisons, France.
Nury T; Team 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA7270/Inserm, University Bourgogne Franche-Comté, 21000 Dijon, France.
Duprey D; Team OCS, Institute of Molecular Chemistry of University of Burgundy (ICMUB UMR CNRS 6302), University of Bourgogne Franche-Comté, 21000 Dijon, France.
Meziane S; Institut Européen des Antioxydants (IEA), 1B, rue Victor de Lespinats, 54230 Neuves-Maisons, France.
Masmoudi-Kouki O; Laboratory of Neurophysiology, Cellular Physiopathology and Valorisation of Biomolecules, (LR18ES03), Department of Biology, Faculty of Sciences, University Tunis El Manar, Tunis 2092, Tunisia.
Latruffe N; Team 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA7270/Inserm, University Bourgogne Franche-Comté, 21000 Dijon, France.
Ghrairi T; Laboratory of Neurophysiology, Cellular Physiopathology and Valorisation of Biomolecules, (LR18ES03), Department of Biology, Faculty of Sciences, University Tunis El Manar, Tunis 2092, Tunisia.
Prost M; Laboratoire Spiral, 21560 Couternon, France.
Lizard G; Team 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA7270/Inserm, University Bourgogne Franche-Comté, 21000 Dijon, France.
Vervandier-Fasseur D; Team OCS, Institute of Molecular Chemistry of University of Burgundy (ICMUB UMR CNRS 6302), University of Bourgogne Franche-Comté, 21000 Dijon, France.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jul 23; Vol. 27 (15). Date of Electronic Publication: 2022 Jul 23.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemistry
Stilbenes*/chemistry
Stilbenes*/pharmacology
Animals ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Imines/pharmacology ; Mice ; Resveratrol/pharmacology
Czasopismo naukowe
Tytuł:
Design, Synthesis and Cytotoxicity of Thiazole-Based Stilbene Analogs as Novel DNA Topoisomerase IB Inhibitors.
Autorzy:
Liu JC; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Chen B; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Yang JL; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Weng JQ; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Yu Q; School of Clinical Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Hu DX; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Feb 02; Vol. 27 (3). Date of Electronic Publication: 2022 Feb 02.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*chemistry
Stilbenes/*chemistry
Thiazoles/*chemistry
Topoisomerase Inhibitors/*chemistry
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Drug Design ; HCT116 Cells ; Humans ; MCF-7 Cells ; Molecular Docking Simulation ; Neoplasms/drug therapy ; Stilbenes/chemical synthesis ; Stilbenes/pharmacology ; Thiazoles/chemical synthesis ; Thiazoles/pharmacology ; Topoisomerase Inhibitors/chemical synthesis ; Topoisomerase Inhibitors/pharmacology
Czasopismo naukowe
Tytuł:
Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect.
Autorzy:
Ibrahim TS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Hawwas MM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Malebari AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Taher ES; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Omar AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Neamatallah T; Department of Pharmacology and toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Abdel-Samii ZK; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Safo MK; Institute for Structural Biology, Drug Discovery and Development, Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, USA.
Elshaier YAMM; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Menoufia, Egypt.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 802-818.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Discovery*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Quinolines/*pharmacology
Stilbenes/*pharmacology
Tubulin/*metabolism
Tubulin Modulators/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Polymerization/drug effects ; Quinolines/chemical synthesis ; Quinolines/chemistry ; Reactive Oxygen Species/metabolism ; Stilbenes/chemical synthesis ; Stilbenes/chemistry ; Structure-Activity Relationship ; Tubulin Modulators/chemical synthesis ; Tubulin Modulators/chemistry
Czasopismo naukowe
Tytuł:
Chloroquine Potentiates the Anticancer Effect of Pterostilbene on Pancreatic Cancer by Inhibiting Autophagy and Downregulating the RAGE/STAT3 Pathway.
Autorzy:
Chen RJ; Department of Food Safety/Hygiene and Risk Management, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan.
Lyu YJ; Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan.
Chen YY; Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan.
Lee YC; Department of Medical Oncology, Tainan Hospital, Ministry of Health and Welfare, Executive Yuan, Tainan 70043, Taiwan.; Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan 70403, Taiwan.
Pan MH; Institute of Food Science and Technology, National Taiwan University, Taipei 10617, Taiwan.
Ho YS; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Cancer Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan.; School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Wang YJ; Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan.; Master Degree Program in Toxicology, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Nov 08; Vol. 26 (21). Date of Electronic Publication: 2021 Nov 08.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Autophagy/*drug effects
Carcinoma, Pancreatic Ductal/*drug therapy
Chloroquine/*pharmacology
Pancreatic Neoplasms/*drug therapy
Stilbenes/*pharmacology
Antigens, Neoplasm/metabolism ; Antineoplastic Agents/chemistry ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Chloroquine/chemistry ; Down-Regulation/drug effects ; Drug Screening Assays, Antitumor ; Humans ; Mitogen-Activated Protein Kinases/antagonists & inhibitors ; Mitogen-Activated Protein Kinases/metabolism ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; STAT3 Transcription Factor/antagonists & inhibitors ; STAT3 Transcription Factor/metabolism ; Stilbenes/chemistry
Czasopismo naukowe
Tytuł:
Design and synthesis of new trimethoxylphenyl-linked combretastatin analogues loaded on diamond nanoparticles as a panel for ameliorated solubility and antiproliferative activity.
Autorzy:
Zaki I; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Port Said University, Port Said, Egypt.
Moustafa AMY; Chemistry Department, Faculty of Science, Port Said University, Port Said, Egypt.
Beshay BY; Pharmaceutical Sciences (Pharmaceutical Chemistry) Department, College of Pharmacy, Arab Academy for Science, Technology and Maritime Transport, Alexandria, Egypt.
Masoud RE; Clinical Pharmacology Department, Faculty of Medicine, Port Said University, Port Said, Egypt.
Elbastawesy MAI; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Abourehab MAS; Department of Pharmaceutics, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.; Department of Pharmaceutics, College of Pharmacy, Minia University, Minia, Egypt.
Zakaria MY; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Port Said University, Port Said, Egypt.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 2679-2701.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Nanoparticles*
Amides/pharmacology ; Bibenzyls ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Molecular Structure ; Solubility ; Stilbenes ; Structure-Activity Relationship ; Tubulin/metabolism ; Tubulin Modulators/pharmacology
Czasopismo naukowe
Tytuł:
Piceatannol, a Structural Analog of Resveratrol, Is an Apoptosis Inducer and a Multidrug Resistance Modulator in HL-60 Human Acute Myeloid Leukemia Cells.
Autorzy:
Siedlecka-Kroplewska K; Department of Histology, Medical University of Gdańsk, 80-211 Gdańsk, Poland.
Wrońska A; Department of Histology, Medical University of Gdańsk, 80-211 Gdańsk, Poland.
Kmieć Z; Department of Histology, Medical University of Gdańsk, 80-211 Gdańsk, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 30; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 30.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Drug Resistance, Multiple/*drug effects
Leukemia, Myeloid, Acute/*metabolism
Resveratrol/*analogs & derivatives
Stilbenes/*pharmacology
ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Antineoplastic Agents/chemistry ; Autophagy/drug effects ; Caspase 3/metabolism ; Cell Cycle/drug effects ; Cell Survival/drug effects ; DNA Fragmentation/drug effects ; HL-60 Cells ; Humans ; Inhibitory Concentration 50 ; Leukemia, Myeloid, Acute/pathology ; Membrane Potential, Mitochondrial/drug effects ; Molecular Structure ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Stilbenes/chemistry
Czasopismo naukowe
Tytuł:
Enhancement of Anticancer Potential of Pterostilbene Derivative by Chalcone Hybridization.
Autorzy:
Tang KW; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Ke CC; Department of Medical Imaging and Radiological Sciences, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Tseng CH; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.; Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Department of Pharmacy, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 801, Taiwan.
Chen YL; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Department of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Tzeng CC; Department of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Chen YJ; Department of Medical Imaging and Radiological Sciences, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Hsu CC; Department of Medical Imaging and Radiological Sciences, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Tai HT; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Hsieh YJ; Department of Medical Imaging and Radiological Sciences, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Aug 10; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 10.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Chalcone/*pharmacology
Stilbenes/*pharmacology
Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Caspases/metabolism ; Cell Cycle Checkpoints/drug effects ; Cell Cycle Proteins/metabolism ; Cell Death/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chalcone/chemistry ; Drug Evaluation, Preclinical ; Enzyme Activation/drug effects ; Humans ; Inhibitory Concentration 50 ; Poly(ADP-ribose) Polymerases/metabolism ; Stilbenes/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Co-administration of combretastatin A4 nanoparticles and anti-PD-L1 for synergistic therapy of hepatocellular carcinoma.
Autorzy:
Zhao B; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Dong Z; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Liu W; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Lou F; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Wang Q; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Hong H; School of Medicine, Nanjing University, 22 Hankou Road, Nanjing, 210093, China. .
Wang Y; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China. zwy_.
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Źródło:
Journal of nanobiotechnology [J Nanobiotechnology] 2021 May 01; Vol. 19 (1), pp. 124. Date of Electronic Publication: 2021 May 01.
Typ publikacji:
Journal Article
MeSH Terms:
Antibodies, Monoclonal, Humanized/*pharmacology
Antineoplastic Agents/*pharmacology
Carcinoma, Hepatocellular/*drug therapy
Liver Neoplasms/*drug therapy
Nanoparticles/*administration & dosage
Stilbenes/*administration & dosage
Animals ; Antibodies, Monoclonal, Humanized/chemistry ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Agents/therapeutic use ; B7-H1 Antigen ; Carcinoma, Hepatocellular/pathology ; Disease Models, Animal ; Drug Synergism ; Female ; Humans ; Liver Neoplasms/pathology ; Mice ; Mice, Inbred C57BL ; Nanoparticles/chemistry ; Polyethylene Glycols ; Stilbenes/chemistry ; Tumor Microenvironment/drug effects
Czasopismo naukowe
Tytuł:
Imidazole Analogs of Vascular-Disrupting Combretastatin A-4 with Pleiotropic Efficacy against Resistant Colorectal Cancer Models.
Autorzy:
Reipsch F; University Clinic for Internal Medicine IV, Hematology/Oncology, Medical Faculty, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Biersack B; Organic Chemistry Laboratory, University of Bayreuth, Universitätsstraße 30, 95440 Bayreuth, Germany.
Lucas H; Institute of Pharmacy, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Schobert R; Organic Chemistry Laboratory, University of Bayreuth, Universitätsstraße 30, 95440 Bayreuth, Germany.
Mueller T; University Clinic for Internal Medicine IV, Hematology/Oncology, Medical Faculty, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 03; Vol. 22 (23). Date of Electronic Publication: 2021 Dec 03.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Bibenzyls/*pharmacology
Colorectal Neoplasms/*drug therapy
Imidazoles/*chemistry
Tubulin Modulators/*pharmacology
Animals ; Antineoplastic Agents/therapeutic use ; Bibenzyls/chemistry ; Cell Line, Tumor ; Female ; HCT116 Cells ; HT29 Cells ; Humans ; Male ; Mice, Nude ; Stilbenes ; Structure-Activity Relationship ; Tubulin Modulators/therapeutic use ; Xenograft Model Antitumor Assays ; Mice
Czasopismo naukowe
Tytuł:
Piceatannol ameliorates behavioural, biochemical and histological aspects in cisplatin-induced peripheral neuropathy in rats.
Autorzy:
Wahdan SA; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Elsherbiny DA; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Azab SS; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
El-Demerdash E; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
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Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2021 Dec; Vol. 129 (6), pp. 486-495. Date of Electronic Publication: 2021 Sep 23.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*toxicity
Cisplatin/*toxicity
Peripheral Nervous System Diseases/*prevention & control
Stilbenes/*pharmacology
Animals ; Behavior, Animal/drug effects ; Hand Strength ; Locomotion/drug effects ; Male ; Peripheral Nervous System Diseases/chemically induced ; Rats ; Rats, Wistar ; Sciatic Nerve/drug effects
Czasopismo naukowe
Tytuł:
Review on target domains and natural compound-based inhibitors of fatty acid synthase for anticancer drug discovery.
Autorzy:
Pulla LSS; Department of Pharmacy, Birla Institute of Technology and Science (BITS)-Pilani, Hyderabad, India.
Begum Ahil S; Department of Pharmacy, Birla Institute of Technology and Science (BITS)-Pilani, Hyderabad, India.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2021 Nov; Vol. 98 (5), pp. 869-884. Date of Electronic Publication: 2021 Sep 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Antineoplastic Agents/*chemistry
Biological Products/*chemistry
Fatty Acid Synthases/*antagonists & inhibitors
Antineoplastic Agents/pharmacology ; Biological Products/pharmacology ; Catalytic Domain ; Drug Discovery ; Drug Screening Assays, Antitumor ; Flavonoids/chemistry ; Humans ; Polyphenols/chemistry ; Protein Binding ; Resveratrol/chemistry ; Stilbenes/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Stilbene Compounds Inhibit Tumor Growth by the Induction of Cellular Senescence and the Inhibition of Telomerase Activity.
Autorzy:
Lee YH; Department of Food Safety/Hygiene and Risk Management, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan. .
Chen YY; Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan. .
Yeh YL; Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan. .
Wang YJ; Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan. .; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan. .
Chen RJ; Department of Food Safety/Hygiene and Risk Management, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Jun 02; Vol. 20 (11). Date of Electronic Publication: 2019 Jun 02.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Antineoplastic Agents/*therapeutic use
Cellular Senescence/*drug effects
Neoplasms/*drug therapy
Stilbenes/*therapeutic use
Telomerase/*antagonists & inhibitors
Animals ; Antineoplastic Agents/pharmacology ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology ; Resveratrol/pharmacology ; Resveratrol/therapeutic use ; Stilbenes/pharmacology ; Telomerase/metabolism
Czasopismo naukowe
Tytuł:
DNA-binding affinity, cytotoxicity, apoptosis, cell cycle inhibition and molecular docking studies of a new stilbene derivative.
Autorzy:
Mehdipour M; a Department of Biology, Faculty of Natural Science s, University of Tabriz , Tabriz , Iran.
Dehghan G; a Department of Biology, Faculty of Natural Science s, University of Tabriz , Tabriz , Iran.
Yekta R; a Department of Biology, Faculty of Natural Science s, University of Tabriz , Tabriz , Iran.
Hanifeh Ahagh M; a Department of Biology, Faculty of Natural Science s, University of Tabriz , Tabriz , Iran.
Mahdavi M; a Department of Biology, Faculty of Natural Science s, University of Tabriz , Tabriz , Iran.
Ghasemi Z; b Department of Organic Chemistry and Biochemistry, Faculty of Chemistry , University of Tabriz , Tabriz , Iran.
Fathi Z; b Department of Organic Chemistry and Biochemistry, Faculty of Chemistry , University of Tabriz , Tabriz , Iran.
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Źródło:
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2019; Vol. 38 (2), pp. 101-118. Date of Electronic Publication: 2019 Mar 31.
Typ publikacji:
Journal Article
MeSH Terms:
Molecular Docking Simulation*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
DNA/*drug effects
Stilbenes/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Binding Sites/drug effects ; Cattle ; Cell Cycle Checkpoints/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; K562 Cells ; Molecular Structure ; Stilbenes/chemical synthesis ; Stilbenes/chemistry ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe

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