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Tytuł:
Protein kinase inhibitor selectivity "hinges" on evolution.
Autorzy:
Shrestha S; Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.
Bendzunas G; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.
Kannan N; Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Dec 01; Vol. 30 (12), pp. 1561-1563.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Structural and functional insights into CST tethering in Tetrahymena thermophila telomerase.
Autorzy:
Ma Y; Shanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China.
Huang C; Shanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China.
Tang T; CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Wu B; National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China.
Xue H; National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China.
Cao Y; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Wu J; Shanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China. Electronic address: .
Wan B; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: .
Lei M; Shanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Dec 01; Vol. 30 (12), pp. 1565-1572.e4.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Two siblings, distinct characteristics.
Autorzy:
Wang J; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
Billadeau DD; Division of Oncology Research and Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: .
Jia D; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Dec 01; Vol. 30 (12), pp. 1559-1560.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Tethering CST to the telomerase catalytic core-the p50 linchpin.
Autorzy:
Joseph NA; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Chen LY; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Dec 01; Vol. 30 (12), pp. 1563-1564.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Molecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor.
Autorzy:
Asada H; Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan. Electronic address: .
Im D; Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Hotta Y; Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Yasuda S; Graduate School of Science, Chiba University, 1-33 Yayoi-cho, Inage, Chiba 263-8522, Japan; Membrane Protein Research and Molecular Chirality Research Centers, Chiba University, 1-33 Yayoi-cho, Inage, Chiba 263-8522, Japan.
Murata T; Graduate School of Science, Chiba University, 1-33 Yayoi-cho, Inage, Chiba 263-8522, Japan; Membrane Protein Research and Molecular Chirality Research Centers, Chiba University, 1-33 Yayoi-cho, Inage, Chiba 263-8522, Japan.
Suno R; Department of Medical Chemistry, Kansai Medical University, Hirakata 573-1010, Japan.
Iwata S; Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Dec 01; Vol. 30 (12), pp. 1582-1589.e4. Date of Electronic Publication: 2022 Nov 22.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Structure of the divergent human astrovirus MLB capsid spike.
Autorzy:
Delgado-Cunningham K; Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
López T; Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, 62210, Mexico.
Khatib F; Department of Computer and Information Science, University of Massachusetts Dartmouth, Dartmouth, MA 02747, USA.
Arias CF; Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, 62210, Mexico.
DuBois RM; Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Dec 01; Vol. 30 (12), pp. 1573-1581.e3. Date of Electronic Publication: 2022 Nov 22.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Tandem engagement of phosphotyrosines by the dual SH2 domains of p120RasGAP.
Autorzy:
Stiegler AL; Department of Pharmacology, Yale University, New Haven, CT, USA.
Vish KJ; Department of Pharmacology, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Boggon TJ; Department of Pharmacology, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA; Yale Cancer Center, Yale University, New Haven, CT, USA. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Dec 01; Vol. 30 (12), pp. 1603-1614.e5. Date of Electronic Publication: 2022 Nov 22.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Structure of the RhlR-PqsE complex from Pseudomonas aeruginosa reveals mechanistic insights into quorum-sensing gene regulation.
Autorzy:
Feathers JR; Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
Richael EK; Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Simanek KA; Department of Biomedical Sciences, University at Albany, School of Public Health, Albany, NY 12201, USA.
Fromme JC; Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
Paczkowski JE; Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA; Department of Biomedical Sciences, University at Albany, School of Public Health, Albany, NY 12201, USA. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Dec 01; Vol. 30 (12), pp. 1626-1636.e4. Date of Electronic Publication: 2022 Nov 14.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Structural basis for the carotenoid binding and transport function of a START domain.
Autorzy:
Sluchanko NN; A.N. Bach Institute of Biochemistry, Federal Research Center of Biotechnology of the Russian Academy of Sciences, 33 Leninsky Prospect, Building 1, Moscow 119071, Russian Federation. Electronic address: .
Slonimskiy YB; A.N. Bach Institute of Biochemistry, Federal Research Center of Biotechnology of the Russian Academy of Sciences, 33 Leninsky Prospect, Building 1, Moscow 119071, Russian Federation.
Egorkin NA; A.N. Bach Institute of Biochemistry, Federal Research Center of Biotechnology of the Russian Academy of Sciences, 33 Leninsky Prospect, Building 1, Moscow 119071, Russian Federation.
Varfolomeeva LA; A.N. Bach Institute of Biochemistry, Federal Research Center of Biotechnology of the Russian Academy of Sciences, 33 Leninsky Prospect, Building 1, Moscow 119071, Russian Federation.
Kleymenov SY; Koltzov Institute of Developmental Biology of Russian Academy of Sciences, 26 Vavilov Street, Moscow, 119334, Russia.
Minyaev ME; N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prospect, Moscow 119991, Russian Federation.
Faletrov YV; Research Institute for Physical Chemical Problems, Belarusian State University, 14 Leningradskaya Street, Minsk 220030, Belarus.
Moysenovich AM; M.V. Lomonosov Moscow State University, Faculty of Biology, 1 Lenin Hills, Building 12, Moscow 119991, Russian Federation.
Parshina EY; M.V. Lomonosov Moscow State University, Faculty of Biology, 1 Lenin Hills, Building 12, Moscow 119991, Russian Federation.
Friedrich T; Technical University of Berlin, Institute of Chemistry PC 14, Straße des 17. Juni 135, D-10623 Berlin, Germany.
Maksimov EG; M.V. Lomonosov Moscow State University, Faculty of Biology, 1 Lenin Hills, Building 12, Moscow 119991, Russian Federation.
Boyko KM; A.N. Bach Institute of Biochemistry, Federal Research Center of Biotechnology of the Russian Academy of Sciences, 33 Leninsky Prospect, Building 1, Moscow 119071, Russian Federation.
Popov VO; A.N. Bach Institute of Biochemistry, Federal Research Center of Biotechnology of the Russian Academy of Sciences, 33 Leninsky Prospect, Building 1, Moscow 119071, Russian Federation; Research Center 'Kurchatov Institute', 1 Akademika Kurchatova sqr., Moscow 123182, Russian Federation.
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Dec 01; Vol. 30 (12), pp. 1647-1659.e4. Date of Electronic Publication: 2022 Nov 09.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964.
Autorzy:
Kelso S; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
O'Brien S; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada; Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 1A8, Canada.
Kurinov I; Department of Chemistry and Chemical Biology, Cornell University, NE-CAT, Argonne, IL 60439, USA.
Angers S; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada; Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 1A8, Canada; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada. Electronic address: .
Sicheri F; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Dec 01; Vol. 30 (12), pp. 1615-1625.e4. Date of Electronic Publication: 2022 Nov 02.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins.
Autorzy:
Healy MD; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
Sacharz J; Department of Biochemistry and Pharmacology, The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3052, Australia.
McNally KE; School of Biochemistry, Biomedical Sciences Building, University of Bristol, Bristol BS8 1TD, UK.
McConville C; Department of Biochemistry and Pharmacology, The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3052, Australia.
Tillu VA; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
Hall RJ; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
Chilton M; School of Biochemistry, Biomedical Sciences Building, University of Bristol, Bristol BS8 1TD, UK.
Cullen PJ; School of Biochemistry, Biomedical Sciences Building, University of Bristol, Bristol BS8 1TD, UK.
Mobli M; Centre for Advanced Imaging and School of Chemistry and Molecular Biology, The University of Queensland, St. Lucia, QLD 4072, Australia.
Ghai R; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
Stroud DA; Department of Biochemistry and Pharmacology, The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3052, Australia.
Collins BM; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Dec 01; Vol. 30 (12), pp. 1590-1602.e6. Date of Electronic Publication: 2022 Oct 26.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Crystal structure of the AlbEF complex involved in subtilosin A biosynthesis.
Autorzy:
Ishida K; Department of Life Science, Graduate School of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan.
Nakamura A; Department of Life Science, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan. Electronic address: .
Kojima S; Department of Life Science, Graduate School of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan; Department of Life Science, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan.
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Dec 01; Vol. 30 (12), pp. 1637-1646.e3. Date of Electronic Publication: 2022 Oct 26.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Chemical modulation of microtubule structure through the laulimalide/peloruside site.
Autorzy:
Estévez-Gallego J; Centro de Investigaciones Biológicas Margarita Salas - Consejo Superior de Investigaciones Científicas, Madrid 28040, Spain.
Álvarez-Bernad B; Centro de Investigaciones Biológicas Margarita Salas - Consejo Superior de Investigaciones Científicas, Madrid 28040, Spain.
Pera B; Centro de Investigaciones Biológicas Margarita Salas - Consejo Superior de Investigaciones Científicas, Madrid 28040, Spain.
Wullschleger C; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences - ETH Zurich, Zürich 8093, Switzerland.
Raes O; Department of Organic and Macromolecular Chemistry, Ghent University, Gent 9000, Belgium.
Menche D; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Martínez JC; ALBA Synchrotron, CELLS, Cerdanyola del Vallés 08290, Spain.
Lucena-Agell D; Centro de Investigaciones Biológicas Margarita Salas - Consejo Superior de Investigaciones Científicas, Madrid 28040, Spain.
Prota AE; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, Villigen 5232, Switzerland.
Bonato F; Centro de Investigaciones Biológicas Margarita Salas - Consejo Superior de Investigaciones Científicas, Madrid 28040, Spain.
Bargsten K; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, Villigen 5232, Switzerland.
Cornelus J; Department of Organic and Macromolecular Chemistry, Ghent University, Gent 9000, Belgium.
Giménez-Abián JF; Centro de Investigaciones Biológicas Margarita Salas - Consejo Superior de Investigaciones Científicas, Madrid 28040, Spain.
Northcote P; Ferrier Research Institute, University of Wellington, Lower Hutt 5010, New Zealand.
Steinmetz MO; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, Villigen 5232, Switzerland; University of Basel, Biozentrum, Basel 4056, Switzerland.
Kamimura S; Department of Biological Sciences, Faculty of Science and Engineering, Chuo University, Tokyo 192-0393, Japan.
Altmann KH; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences - ETH Zurich, Zürich 8093, Switzerland.
Paterson I; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Gago F; Department of Biomedical Sciences and Associated Unit IQM-UAH, Universidad de Alcalá, Alcalá de Henares 28805, Spain.
Van der Eycken J; Department of Organic and Macromolecular Chemistry, Ghent University, Gent 9000, Belgium.
Díaz JF; Centro de Investigaciones Biológicas Margarita Salas - Consejo Superior de Investigaciones Científicas, Madrid 28040, Spain.
Oliva MÁ; Centro de Investigaciones Biológicas Margarita Salas - Consejo Superior de Investigaciones Científicas, Madrid 28040, Spain. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Nov 19. Date of Electronic Publication: 2022 Nov 19.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Pulling the wool over a pathogen's eyes: Llama nanobody inhibitors of the bacterial SOS response.
Autorzy:
Chen E; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Culyba MJ; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Nov 03; Vol. 30 (11), pp. 1467-1469.
Typ publikacji:
Journal Article; Comment
MeSH Terms:
SOS Response, Genetics*
Camelids, New World*/metabolism
Animals ; Rec A Recombinases/genetics ; Rec A Recombinases/metabolism ; Wool/metabolism ; Bacterial Proteins/genetics ; Serine Endopeptidases/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Bacteria/metabolism
Czasopismo naukowe
Tytuł:
Hitting them where it hurts: Pantothenate kinase targeting in pathogenic fungi.
Autorzy:
Pierce C; Department of Biochemistry & Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA.
Park H; Department of Biochemistry & Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Nov 03; Vol. 30 (11), pp. 1463-1464.
Typ publikacji:
Journal Article; Comment
MeSH Terms:
Phosphotransferases (Alcohol Group Acceptor)*/chemistry
High-Throughput Screening Assays*
Fungi
Czasopismo naukowe
Tytuł:
Trapping Tribbles: Nanobody-assisted structure of the TRIB2 pseudokinase.
Autorzy:
Santana FR; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158, USA.
Linossi EM; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158, USA.
Jura N; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94158, USA. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Nov 03; Vol. 30 (11), pp. 1465-1467.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Comment
MeSH Terms:
Calcium-Calmodulin-Dependent Protein Kinases*/metabolism
Intracellular Signaling Peptides and Proteins*/genetics
Intracellular Signaling Peptides and Proteins*/metabolism
Humans ; Protein Serine-Threonine Kinases/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł:
A memetic algorithm enables efficient local and global all-atom protein-protein docking with backbone and side-chain flexibility.
Autorzy:
Varela D; Division of Biochemistry and Structural Biology, Department of Chemistry, Lund University, 22100 Lund, Sweden.
Karlin V; Division of Biochemistry and Structural Biology, Department of Chemistry, Lund University, 22100 Lund, Sweden.
André I; Division of Biochemistry and Structural Biology, Department of Chemistry, Lund University, 22100 Lund, Sweden. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Nov 03; Vol. 30 (11), pp. 1550-1558.e3. Date of Electronic Publication: 2022 Oct 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Algorithms*
Proteins*/metabolism
Models, Molecular ; Monte Carlo Method ; Molecular Conformation ; Protein Conformation
Czasopismo naukowe
Tytuł:
Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering.
Autorzy:
Gerlits O; Department of Natural Sciences, Tennessee Wesleyan University, Athens, TN 37303, USA.
Fajer M; Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA.
Cheng X; Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Blumenthal DK; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.
Radić Z; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093-0657, USA. Electronic address: .
Kovalevsky A; Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Nov 03; Vol. 30 (11), pp. 1538-1549.e3. Date of Electronic Publication: 2022 Oct 19.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
MeSH Terms:
Acetylcholinesterase*/chemistry
Pesticides*
Humans ; Paraoxon/chemistry ; Crystallography, X-Ray ; Cholinesterase Inhibitors/chemistry ; Oximes/chemistry ; Organophosphorus Compounds ; Neutrons
Czasopismo naukowe
Tytuł:
Nanobodies targeting LexA autocleavage disclose a novel suppression strategy of SOS-response pathway.
Autorzy:
Maso L; Dipartimento di Biologia, Università degli Studi di Padova, Via Ugo Bassi 58/b, 35131 Padova, Italy.
Vascon F; Dipartimento di Biologia, Università degli Studi di Padova, Via Ugo Bassi 58/b, 35131 Padova, Italy.
Chinellato M; Dipartimento di Biologia, Università degli Studi di Padova, Via Ugo Bassi 58/b, 35131 Padova, Italy.
Goormaghtigh F; Biozentrum, University of Basel, CH-4056 Basel, Switzerland; Cellular and Molecular Microbiology (CM2), Faculté des Sciences, Université Libre de Bruxelles (ULB), 12 rue des Professeurs Jeener et Brachet, B-6041 Brussels, Belgium.
Bellio P; Dipartimento di Scienze Cliniche Applicate e Biotecnologiche, Università degli Studi dell'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.
Campagnaro E; Dipartimento di Biologia, Università degli Studi di Padova, Via Ugo Bassi 58/b, 35131 Padova, Italy.
Van Melderen L; Cellular and Molecular Microbiology (CM2), Faculté des Sciences, Université Libre de Bruxelles (ULB), 12 rue des Professeurs Jeener et Brachet, B-6041 Brussels, Belgium.
Ruzzene M; Dipartimento di Scienze Biomediche, Università degli Studi di Padova, Via Ugo Bassi 58/b, 35131 Padova, Italy.
Pardon E; VIB-VUB Center for Structural Biology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
Angelini A; Dipartimento di Scienze Molecolari e Nanosistemi, Università Ca' Foscari Venezia, via Torino 155, 30172 Mestre, Venice, Italy.
Celenza G; Dipartimento di Scienze Cliniche Applicate e Biotecnologiche, Università degli Studi dell'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.
Steyaert J; VIB-VUB Center for Structural Biology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
Tondi D; Dipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, via Giuseppe Campi 103, 41125 Modena, Italy.
Cendron L; Dipartimento di Biologia, Università degli Studi di Padova, Via Ugo Bassi 58/b, 35131 Padova, Italy. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Nov 03; Vol. 30 (11), pp. 1479-1493.e9. Date of Electronic Publication: 2022 Oct 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
SOS Response, Genetics*
Single-Domain Antibodies*/genetics
Single-Domain Antibodies*/metabolism
Rec A Recombinases/genetics ; Rec A Recombinases/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Anti-Bacterial Agents/pharmacology
Czasopismo naukowe
Tytuł:
Nanobodies identify an activated state of the TRIB2 pseudokinase.
Autorzy:
Jamieson SA; Biochemistry Department, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.
Pudjihartono M; Biochemistry Department, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.
Horne CR; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.
Viloria JS; Department of Physical Chemistry, University of Barcelona, Barcelona, Spain.
Dunlop JL; Biochemistry Department, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.
McMillan HD; Biochemistry Department, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.
Day RC; Biochemistry Department, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.
Keeshan K; Paul O'Gorman Leukaemia Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, Scotland.
Murphy JM; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.
Mace PD; Biochemistry Department, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Nov 03; Vol. 30 (11), pp. 1518-1529.e5. Date of Electronic Publication: 2022 Sep 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Intracellular Signaling Peptides and Proteins*/genetics
Intracellular Signaling Peptides and Proteins*/metabolism
Single-Domain Antibodies*/metabolism
Protein Serine-Threonine Kinases/genetics ; Ubiquitin/metabolism ; Ubiquitination
Czasopismo naukowe

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