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Tytuł :
A simple, cost-effective and rapid method for simultaneous determination of Strychnos nux-vomica alkaloids in blood and Ayurvedic medicines based on ultrasound-assisted dispersive liquid-liquid microextraction-thin-layer chromatography-image analysis.
Autorzy :
Jain R; Forensic Toxicology Division, Central Forensic Science Laboratory, Urput-Kumeria Road, P.O. Maniari Tiniali, Kamrup (Rural), Assam 781125, India.; Forensic Toxicology Division, Central Forensic Science Laboratory, Plot #2, Sector 36-A, Dakshin Marg, Chandigarh 160036, India, and.
Tripathi RM; Forensic Toxicology Division, Central Forensic Science Laboratory, Plot #2, Sector 36-A, Dakshin Marg, Chandigarh 160036, India, and.
Negi A; Forensic Chemistry Division, Central Forensic Science Laboratory, Plot #2, Sector 36-A, Dakshin Marg, Chandigarh 160036, India.
Singh SP; Forensic Toxicology Division, Central Forensic Science Laboratory, Urput-Kumeria Road, P.O. Maniari Tiniali, Kamrup (Rural), Assam 781125, India.
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Źródło :
Journal of chromatographic science [J Chromatogr Sci] 2020 Apr 25; Vol. 58 (5), pp. 477-484.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatography, Thin Layer/*methods
Liquid Phase Microextraction/*methods
Strychnine/*analogs & derivatives
Strychnine/*analysis
Strychnos nux-vomica/*chemistry
Chromatography, Thin Layer/economics ; Cost-Benefit Analysis ; Humans ; Image Processing, Computer-Assisted ; Limit of Detection ; Liquid Phase Microextraction/economics ; Medicine, Ayurvedic ; Reproducibility of Results ; Strychnine/blood ; Tablets/analysis ; Ultrasonics ; Ultraviolet Rays
Czasopismo naukowe
Tytuł :
Activation of glycine receptors in the lateral habenula rescues anxiety- and depression-like behaviors associated with alcohol withdrawal and reduces alcohol intake in rats.
Autorzy :
Li W; Department of Anesthesiology, Pharmacology, & Physiology, and Neuroscience, Rutgers, The State University of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, USA.
Zuo W; Department of Anesthesiology, Pharmacology, & Physiology, and Neuroscience, Rutgers, The State University of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, USA.
Wu W; Department of Anesthesiology, Pharmacology, & Physiology, and Neuroscience, Rutgers, The State University of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, USA.
Zuo QK; Department of Anesthesiology, Pharmacology, & Physiology, and Neuroscience, Rutgers, The State University of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, USA.
Fu R; Department of Anesthesiology, Pharmacology, & Physiology, and Neuroscience, Rutgers, The State University of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, USA.
Wu L; Department of Anesthesiology, Pharmacology, & Physiology, and Neuroscience, Rutgers, The State University of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, USA.
Zhang H; Department of Anesthesiology, Pharmacology, & Physiology, and Neuroscience, Rutgers, The State University of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, USA.
Ndukwe M; Department of Anesthesiology, Pharmacology, & Physiology, and Neuroscience, Rutgers, The State University of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, USA.
Ye JH; Department of Anesthesiology, Pharmacology, & Physiology, and Neuroscience, Rutgers, The State University of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, USA. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2019 Oct; Vol. 157, pp. 107688. Date of Electronic Publication: 2019 Jun 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Alcohol Drinking/*prevention & control
Anxiety/*prevention & control
Depression/*prevention & control
Glycine/*pharmacology
Habenula/*physiology
Neurons/*physiology
Receptors, Glycine/*physiology
Strychnine/*pharmacology
Substance Withdrawal Syndrome/*prevention & control
Action Potentials/physiology ; Animals ; Anxiety/chemically induced ; Anxiety/complications ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Depression/chemically induced ; Depression/complications ; Glycine/administration & dosage ; Glycine/antagonists & inhibitors ; Inhibitory Postsynaptic Potentials/physiology ; Male ; Microinjections ; Neural Inhibition/physiology ; Rats ; Receptors, Glycine/agonists ; Receptors, Glycine/antagonists & inhibitors ; Sarcosine/pharmacology ; Strychnine/administration & dosage ; Substance Withdrawal Syndrome/complications
Czasopismo naukowe
Tytuł :
Cyp3a11 metabolism-based chronotoxicity of brucine in mice.
Autorzy :
Zhou Z; Research Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou, 510632, China.
Lin Y; Research Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou, 510632, China.
Gao L; Research Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou, 510632, China.
Yang Z; Research Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou, 510632, China.
Wang S; Research Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou, 510632, China.
Wu B; Research Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou, 510632, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2019 Oct 01; Vol. 313, pp. 188-195. Date of Electronic Publication: 2019 Jul 05.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Circadian Rhythm*/genetics
Photoperiod*
Chemical and Drug Induced Liver Injury/*enzymology
Cytochrome P-450 CYP3A/*metabolism
Liver/*drug effects
Liver/*enzymology
Membrane Proteins/*metabolism
Strychnine/*analogs & derivatives
Alanine Transaminase/blood ; Animals ; Aspartate Aminotransferases/blood ; Basic Helix-Loop-Helix Transcription Factors/deficiency ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Chemical and Drug Induced Liver Injury/blood ; Chemical and Drug Induced Liver Injury/genetics ; Chemical and Drug Induced Liver Injury/pathology ; Drug Chronotherapy ; HEK293 Cells ; Humans ; Liver/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Microsomes, Liver/drug effects ; Microsomes, Liver/enzymology ; Nerve Tissue Proteins/deficiency ; Nerve Tissue Proteins/genetics ; Strychnine/administration & dosage ; Strychnine/metabolism ; Strychnine/pharmacokinetics ; Strychnine/toxicity
Czasopismo naukowe
Tytuł :
Licorice Extracts Attenuate Nephrotoxicity Induced by Brucine Through Suppression of Mitochondria Apoptotic Pathway and STAT3 Activation.
Autorzy :
Zhang M; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, China.
Wang C; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, China.
Cai HL; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, China.
Wen J; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, China.
Fang PF; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, 410011, China. .; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, China. .
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Źródło :
Current medical science [Curr Med Sci] 2019 Dec; Vol. 39 (6), pp. 890-898. Date of Electronic Publication: 2019 Dec 16.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Kidney Injury/*drug therapy
Glycyrrhiza/*chemistry
Mitochondria/*metabolism
Plant Extracts/*administration & dosage
STAT3 Transcription Factor/*metabolism
Strychnine/*analogs & derivatives
Acute Kidney Injury/chemically induced ; Acute Kidney Injury/metabolism ; Animals ; Apoptosis/drug effects ; Blood Urea Nitrogen ; Creatinine/blood ; Disease Models, Animal ; Gene Expression Regulation/drug effects ; Glutathione/metabolism ; Injections, Intraperitoneal ; Male ; Malondialdehyde/metabolism ; Mitochondria/drug effects ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Strychnine/adverse effects ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Tytuł :
11-Aminostrychnine and N -(Strychnine-11-yl)propionamide: Synthesis, Configuration, and Pharmacological Evaluation at Glycine Receptors.
Autorzy :
Zlotos DP; Faculty of Pharmacy and Biotechnology , The German University in Cairo , New Cairo City, 11835 Cairo , Egypt.
Mohsen AMY; Faculty of Pharmacy and Biotechnology , The German University in Cairo , New Cairo City, 11835 Cairo , Egypt.
Mandour YM; Faculty of Pharmacy and Biotechnology , The German University in Cairo , New Cairo City, 11835 Cairo , Egypt.
Marzouk MA; Faculty of Pharmacy and Biotechnology , The German University in Cairo , New Cairo City, 11835 Cairo , Egypt.
Breitinger U; Faculty of Pharmacy and Biotechnology , The German University in Cairo , New Cairo City, 11835 Cairo , Egypt.
Villmann C; Institute of Clinical Neurobiology , University of Würzburg , 97078 Würzburg , Germany.
Breitinger HG; Faculty of Pharmacy and Biotechnology , The German University in Cairo , New Cairo City, 11835 Cairo , Egypt.
Sotriffer C; Institute of Pharmacy and Food Chemistry , University of Würzburg , 97074 Würzburg , Germany.
Jensen AA; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences , University of Copenhagen , DK-2100 Copenhagen , Denmark.
Holzgrabe U; Institute of Pharmacy and Food Chemistry , University of Würzburg , 97074 Würzburg , Germany.
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Źródło :
Journal of natural products [J Nat Prod] 2019 Aug 23; Vol. 82 (8), pp. 2332-2336. Date of Electronic Publication: 2019 Aug 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amides/*chemistry
Receptors, Glycine/*antagonists & inhibitors
Strychnine/*analogs & derivatives
Carbon-13 Magnetic Resonance Spectroscopy ; Proton Magnetic Resonance Spectroscopy ; Structure-Activity Relationship ; Strychnine/pharmacology
Czasopismo naukowe
Tytuł :
Brucine alleviates neuropathic pain in mice via reducing the current of the sodium channel.
Autorzy :
Yu G; School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, 210023 Jiangsu, China; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, Nanjing University of Chinese Medicine, 138 Xian in Rd, Nanjing, 210023 Jiangsu, China; State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China; Key Laboratory of Drug Target and Drug for Degenerative Disease of Jiangsu Province, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: .
Qian L; School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, 210023 Jiangsu, China; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, Nanjing University of Chinese Medicine, 138 Xian in Rd, Nanjing, 210023 Jiangsu, China. Electronic address: .
Yu J; School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, 210023 Jiangsu, China; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, Nanjing University of Chinese Medicine, 138 Xian in Rd, Nanjing, 210023 Jiangsu, China. Electronic address: .
Tang M; School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, 210023 Jiangsu, China; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, Nanjing University of Chinese Medicine, 138 Xian in Rd, Nanjing, 210023 Jiangsu, China. Electronic address: .
Wang C; School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, 210023 Jiangsu, China; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, Nanjing University of Chinese Medicine, 138 Xian in Rd, Nanjing, 210023 Jiangsu, China. Electronic address: .
Zhou Y; School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, 210023 Jiangsu, China; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, Nanjing University of Chinese Medicine, 138 Xian in Rd, Nanjing, 210023 Jiangsu, China. Electronic address: .
Geng X; School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, 210023 Jiangsu, China; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, Nanjing University of Chinese Medicine, 138 Xian in Rd, Nanjing, 210023 Jiangsu, China. Electronic address: .
Zhu C; School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, 210023 Jiangsu, China; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, Nanjing University of Chinese Medicine, 138 Xian in Rd, Nanjing, 210023 Jiangsu, China. Electronic address: .
Yang Y; School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, 210023 Jiangsu, China; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, Nanjing University of Chinese Medicine, 138 Xian in Rd, Nanjing, 210023 Jiangsu, China. Electronic address: .
Pan Y; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, Nanjing University of Chinese Medicine, 138 Xian in Rd, Nanjing, 210023 Jiangsu, China. Electronic address: .
Shen X; School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, 210023 Jiangsu, China; State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China; Key Laboratory of Drug Target and Drug for Degenerative Disease of Jiangsu Province, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: .
Tang Z; School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, 210023 Jiangsu, China; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, Nanjing University of Chinese Medicine, 138 Xian in Rd, Nanjing, 210023 Jiangsu, China; State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China; Key Laboratory of Drug Target and Drug for Degenerative Disease of Jiangsu Province, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2019 Apr 06; Vol. 233, pp. 56-63. Date of Electronic Publication: 2018 Dec 30.
Typ publikacji :
Journal Article
MeSH Terms :
Analgesics/*pharmacology
Analgesics/*therapeutic use
Neuralgia/*drug therapy
Sodium Channels/*physiology
Strychnine/*analogs & derivatives
Action Potentials/drug effects ; Animals ; Behavior, Animal/drug effects ; Cells, Cultured ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/physiology ; Male ; Mice, Inbred C57BL ; Neuralgia/physiopathology ; Neurons/drug effects ; Neurons/physiology ; Strychnine/pharmacology ; Strychnine/therapeutic use
Czasopismo naukowe
Tytuł :
Brucine Suppresses Vasculogenic Mimicry in Human Triple-Negative Breast Cancer Cell Line MDA-MB-231.
Autorzy :
Xu MR; Department of Chinese Integrative Medicine Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
Wei PF; The CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui 230027, China.; Hefei National Laboratory for Physical Sciences at Microscale, Hefei, Anhui 230027, China.
Suo MZ; Department of Chinese Integrative Medicine Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
Hu Y; The CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui 230027, China.
Ding W; Center for Biomedical Engineering, Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, China.
Su L; Department of Chinese Integrative Medicine Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
Zhu YD; Department of Chinese Integrative Medicine Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
Song WJ; Department of Chinese Integrative Medicine Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
Tang GH; Department of Chinese Integrative Medicine Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
Zhang M; Department of Chinese Integrative Medicine Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
Li P; Department of Chinese Integrative Medicine Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
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Źródło :
BioMed research international [Biomed Res Int] 2019 Jan 06; Vol. 2019, pp. 6543230. Date of Electronic Publication: 2019 Jan 06 (Print Publication: 2019).
Typ publikacji :
Journal Article
MeSH Terms :
Neovascularization, Pathologic/*drug therapy
Strychnine/*analogs & derivatives
Strychnos nux-vomica/*chemistry
Triple Negative Breast Neoplasms/*drug therapy
Apoptosis/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Matrix Metalloproteinase 2/genetics ; Matrix Metalloproteinase 9/genetics ; Neoplasm Invasiveness/genetics ; Neoplasm Invasiveness/pathology ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/pathology ; Strychnine/chemistry ; Strychnine/pharmacology ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Biochemical studies evaluating the chemopreventive potential of brucine in chemically induced mammary carcinogenesis of rats.
Autorzy :
Saminathan U; a Department of Biochemistry and Biotechnology , Annamalai University , Annamalai Nagar , India.
Pugalendhi P; a Department of Biochemistry and Biotechnology , Annamalai University , Annamalai Nagar , India.
Subramaniyan S; a Department of Biochemistry and Biotechnology , Annamalai University , Annamalai Nagar , India.
Jayaganesh R; a Department of Biochemistry and Biotechnology , Annamalai University , Annamalai Nagar , India.
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Źródło :
Toxicology mechanisms and methods [Toxicol Mech Methods] 2019 Jan; Vol. 29 (1), pp. 8-17.
Typ publikacji :
Journal Article
MeSH Terms :
Anticarcinogenic Agents/*pharmacology
Mammary Glands, Animal/*drug effects
Mammary Neoplasms, Experimental/*prevention & control
Oxidative Stress/*drug effects
Strychnine/*analogs & derivatives
9,10-Dimethyl-1,2-benzanthracene/toxicity ; Animals ; Anticarcinogenic Agents/administration & dosage ; Antioxidants/metabolism ; Chemoprevention ; Dose-Response Relationship, Drug ; Female ; Lipid Metabolism/drug effects ; Mammary Glands, Animal/metabolism ; Mammary Glands, Animal/pathology ; Mammary Neoplasms, Experimental/chemically induced ; Mammary Neoplasms, Experimental/metabolism ; Rats, Sprague-Dawley ; Strychnine/administration & dosage ; Strychnine/pharmacology
Czasopismo naukowe
Tytuł :
Microdialysis combined with RRLC-MS/MS for the pharmacokinetics of two major alkaloids of Bi qi capsule and the potential roles of P-gp and BCRP on their penetration.
Autorzy :
Ren T; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, PR China. Electronic address: .
Li M; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, PR China. Electronic address: .
Zheng H; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, PR China. Electronic address: .
Liu W; Tianjin Darentang Jingwanhong Pharmaceutical CO., Ltd., Tianjin 300112, China.
Zhang J; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, PR China. Electronic address: .
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Źródło :
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2018 Aug 15; Vol. 1092, pp. 72-81. Date of Electronic Publication: 2018 May 31.
Typ publikacji :
Journal Article
MeSH Terms :
Drugs, Chinese Herbal*
Strychnine/*analogs & derivatives
Strychnine/*analysis
Strychnine/*pharmacokinetics
Animals ; Brain Chemistry ; Chromatography, Liquid/methods ; Linear Models ; Male ; Microdialysis ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Sensitivity and Specificity ; Strychnine/blood ; Strychnine/chemistry ; Tandem Mass Spectrometry/methods
Czasopismo naukowe
Tytuł :
Identification of the hypertension drug niflumic acid as a glycine receptor inhibitor.
Autorzy :
Ito D; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, 252-5258, Japan.
Kawazoe Y; Saga University Center for Education and Research in Agricultural Innovation, Karatsu, 847-0021, Japan.
Sato A; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, 464-8601, Japan.
Uesugi M; Institute for Chemical Research (ICR) and Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Uji, 611-0011, Japan.
Hirata H; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, 252-5258, Japan. .
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Źródło :
Scientific reports [Sci Rep] 2020 Aug 19; Vol. 10 (1), pp. 13999. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Niflumic Acid/*pharmacology
Receptors, Glycine/*antagonists & inhibitors
Synaptic Transmission/*drug effects
Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Convulsants/pharmacology ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/drug effects ; Embryo, Nonmammalian/physiology ; Female ; Glycine/pharmacology ; Membrane Potentials/drug effects ; Nifedipine/pharmacology ; Oocytes/drug effects ; Oocytes/metabolism ; Oocytes/physiology ; Picrotoxin/pharmacology ; Receptors, Glycine/agonists ; Receptors, Glycine/metabolism ; Strychnine/pharmacology ; Synaptic Transmission/physiology ; Vasodilator Agents/pharmacology ; Xenopus laevis ; Zebrafish/embryology ; Zebrafish/metabolism
Czasopismo naukowe
Tytuł :
In vivo Antimalarial and Antitrypanosomal Activity of Strychnogucine B, a Bisindole Alkaloid from Strychnos icaja.
Autorzy :
Beaufay C; Pharmacognosy Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium.
Ledoux A; Laboratory of Pharmacognosy, CIRM, Université de Liège, Liège, Belgium.
Jansen O; Laboratory of Pharmacognosy, CIRM, Université de Liège, Liège, Belgium.
Bordignon A; Laboratory of Pharmacognosy, CIRM, Université de Liège, Liège, Belgium.
Zhao S; Department of Chemistry, Temple University, Philadelphia, PA, United States of America.
Teijaro CN; Department of Chemistry, Temple University, Philadelphia, PA, United States of America.
Andrade RB; Department of Chemistry, Temple University, Philadelphia, PA, United States of America.
Quetin-Leclercq J; Pharmacognosy Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium.
Frédérich M; Laboratory of Pharmacognosy, CIRM, Université de Liège, Liège, Belgium.
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Źródło :
Planta medica [Planta Med] 2018 Aug; Vol. 84 (12-13), pp. 881-885. Date of Electronic Publication: 2018 Jun 21.
Typ publikacji :
Journal Article
MeSH Terms :
Alkaloids/*pharmacology
Antimalarials/*pharmacology
Plasmodium berghei/*drug effects
Strychnine/*analogs & derivatives
Strychnos/*chemistry
Trypanocidal Agents/*pharmacology
Alkaloids/chemistry ; Animals ; Antimalarials/chemistry ; Disease Models, Animal ; Female ; Leishmania mexicana/drug effects ; Mice ; Strychnine/chemistry ; Strychnine/pharmacology ; Trypanocidal Agents/chemistry ; Trypanosoma brucei brucei/drug effects
Czasopismo naukowe
Tytuł :
Prophylactic Neuroprotection of Total Glucosides of Paeoniae Radix Alba against Semen Strychni-Induced Neurotoxicity in Rats: Suppressing Oxidative Stress and Reducing the Absorption of Toxic Components.
Autorzy :
Li S; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110000, China. .
Chu Y; School of Traditional Chinese Material Medica, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110000, China. .
Zhang R; Southern Research Institute, 2000 9th Ave. s., Birmingham 35205, AL, USA. .
Sun L; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110000, China. .
Chen X; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110000, China. .
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Źródło :
Nutrients [Nutrients] 2018 Apr 20; Vol. 10 (4). Date of Electronic Publication: 2018 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Paeonia*/chemistry
Antioxidants/*pharmacology
Brain/*drug effects
Glucosides/*pharmacology
Neuroprotective Agents/*pharmacology
Neurotoxicity Syndromes/*prevention & control
Oxidative Stress/*drug effects
Plant Extracts/*pharmacology
Strychnine/*analogs & derivatives
Strychnine/*toxicity
Strychnos/*toxicity
Administration, Oral ; Animals ; Antioxidants/isolation & purification ; Behavior, Animal/drug effects ; Brain/metabolism ; Brain/pathology ; Brain/physiopathology ; Chromatography, High Pressure Liquid ; Glucosides/isolation & purification ; Male ; Motor Activity/drug effects ; Neuroprotective Agents/isolation & purification ; Neurotoxicity Syndromes/etiology ; Neurotoxicity Syndromes/metabolism ; Neurotoxicity Syndromes/physiopathology ; Permeability ; Phytotherapy ; Plant Extracts/isolation & purification ; Plants, Medicinal ; Rats, Sprague-Dawley ; Strychnine/administration & dosage ; Strychnine/metabolism ; Tandem Mass Spectrometry ; Time Factors ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Toxicokinetics of strychnine and brucine after the oral administration of Biqi capsule to rats by RRLC-MS/MS.
Autorzy :
Zheng H; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Wang Z; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Liu W; Tianjin Darentang Jingwanhong Pharmaceutical Co. Ltd, Tianjin, China.
Jin H; New Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Zhang J; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
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Źródło :
Biomedical chromatography : BMC [Biomed Chromatogr] 2018 Mar; Vol. 32 (3). Date of Electronic Publication: 2017 Nov 03.
Typ publikacji :
Journal Article
MeSH Terms :
Drugs, Chinese Herbal/*administration & dosage
Strychnine/*analogs & derivatives
Strychnine/*blood
Strychnine/*pharmacokinetics
Administration, Oral ; Animals ; Chromatography, Liquid ; Drugs, Chinese Herbal/pharmacokinetics ; Female ; Linear Models ; Male ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Sensitivity and Specificity ; Strychnine/toxicity ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Determination of the conformational states of strychnine in solution using NMR residual dipolar couplings in a tensor-free approach.
Autorzy :
Tomba G; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.
Camilloni C; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.
Vendruscolo M; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom. Electronic address: .
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Źródło :
Methods (San Diego, Calif.) [Methods] 2018 Sep 15; Vol. 148, pp. 4-8. Date of Electronic Publication: 2018 Jul 21.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Conformation*
Molecular Dynamics Simulation*
Nuclear Magnetic Resonance, Biomolecular/*methods
Strychnine/*chemistry
Strychnine/analysis
Czasopismo naukowe
Tytuł :
Wnt/β-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells.
Autorzy :
Shi X; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta Weststreet, #54, Xi'an, Shaanxi 710061, PR China.
Zhu M; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta Weststreet, #54, Xi'an, Shaanxi 710061, PR China.
Kang Y; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta Weststreet, #54, Xi'an, Shaanxi 710061, PR China.
Yang T; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta Weststreet, #54, Xi'an, Shaanxi 710061, PR China.
Chen X; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta Weststreet, #54, Xi'an, Shaanxi 710061, PR China.
Zhang Y; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta Weststreet, #54, Xi'an, Shaanxi 710061, PR China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2018 Jul 15; Vol. 46, pp. 85-92. Date of Electronic Publication: 2018 Apr 10.
Typ publikacji :
Journal Article
MeSH Terms :
Wnt Signaling Pathway*
Cell Movement/*drug effects
Colorectal Neoplasms/*drug therapy
Strychnine/*analogs & derivatives
Animals ; Apoptosis/drug effects ; Axin Protein/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival ; Down-Regulation ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Male ; Matrix Metalloproteinases/metabolism ; Mice ; Mice, Nude ; Strychnine/pharmacology ; Xenograft Model Antitumor Assays ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
An LC-MS/MS method for determination of bioactive components of liquorice and Semen Strychni in rat plasma: Application to a pharmacokinetics study.
Autorzy :
Zhang M; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, China.; Institute of Clinical Pharmacy, Central South University, Changsha, China.
Deng Y; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, China.; Institute of Clinical Pharmacy, Central South University, Changsha, China.
Wang C; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, China.; Institute of Clinical Pharmacy, Central South University, Changsha, China.
Cai HL; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, China.; Institute of Clinical Pharmacy, Central South University, Changsha, China.
Wen J; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, China.; Institute of Clinical Pharmacy, Central South University, Changsha, China.
Fang PF; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, China.; Institute of Clinical Pharmacy, Central South University, Changsha, China.
Zhang BK; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, China.; Institute of Clinical Pharmacy, Central South University, Changsha, China.
Li HD; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, China.; Institute of Clinical Pharmacy, Central South University, Changsha, China.
Yan M; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, China.; Institute of Clinical Pharmacy, Central South University, Changsha, China.
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Źródło :
Drug testing and analysis [Drug Test Anal] 2018 Feb; Vol. 10 (2), pp. 262-271. Date of Electronic Publication: 2017 Jul 26.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatography, Liquid/*methods
Flavanones/*chemistry
Glucosides/*chemistry
Glycyrrhiza/*chemistry
Glycyrrhizic Acid/*chemistry
Plasma/*chemistry
Semen/*chemistry
Strychnine/*analogs & derivatives
Animals ; Flavanones/metabolism ; Glucosides/metabolism ; Glycyrrhiza/metabolism ; Rats ; Reproducibility of Results ; Strychnine/chemistry ; Strychnine/pharmacokinetics
Czasopismo naukowe
Tytuł :
Brucine suppresses breast cancer metastasis via inhibiting epithelial mesenchymal transition and matrix metalloproteinases expressions.
Autorzy :
Li M; Department of Geriatrics, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui Province, 233000, China.
Li P; Department of Chinese Medicine Tumor, the Affiliated Provincial Hospital of Anhui Medical University, Hefei, 230001, China. .
Zhang M; Department of Chinese Medicine Tumor, the Affiliated Provincial Hospital of Anhui Medical University, Hefei, 230001, China.
Ma F; Department of Chinese Medicine Tumor, the Affiliated Provincial Hospital of Anhui Medical University, Hefei, 230001, China.
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Źródło :
Chinese journal of integrative medicine [Chin J Integr Med] 2018 Jan; Vol. 24 (1), pp. 40-46. Date of Electronic Publication: 2017 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
Epithelial-Mesenchymal Transition*/drug effects
Breast Neoplasms/*drug therapy
Breast Neoplasms/*enzymology
Matrix Metalloproteinase 2/*metabolism
Matrix Metalloproteinase 9/*metabolism
Strychnine/*analogs & derivatives
Biomarkers, Tumor/metabolism ; Breast Neoplasms/pathology ; Cell Adhesion/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Survival/drug effects ; Collagen/pharmacology ; Drug Combinations ; Female ; Humans ; Laminin/pharmacology ; Neoplasm Invasiveness ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Proteoglycans/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Strychnine/chemistry ; Strychnine/pharmacology ; Strychnine/therapeutic use
Czasopismo naukowe
Tytuł :
Sensitive detection of brucine an anti-metastatic drug for hepatocellular carcinoma at carbon nanotubes - nafion composite based biosensor.
Autorzy :
Savalia R; Department of Chemistry, Institute of Chemical Technology, Matunga, Mumbai 400019, India.
Chatterjee S; Department of Chemistry, Institute of Chemical Technology, Matunga, Mumbai 400019, India. Electronic address: .
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Źródło :
Biosensors & bioelectronics [Biosens Bioelectron] 2017 Dec 15; Vol. 98, pp. 371-377. Date of Electronic Publication: 2017 Jul 06.
Typ publikacji :
Journal Article
MeSH Terms :
Biosensing Techniques*
Carcinoma, Hepatocellular*/blood
Carcinoma, Hepatocellular*/urine
Liver Neoplasms*/blood
Liver Neoplasms*/urine
Strychnine/*analogs & derivatives
Cell Line, Tumor ; Electrochemical Techniques/methods ; Humans ; Nanotubes, Carbon/chemistry ; Strychnine/blood ; Strychnine/urine
Czasopismo naukowe

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