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Wyświetlanie 1-11 z 11
Tytuł :
Impact of mRNA chemistry and manufacturing process on innate immune activation.
Autorzy :
Nelson J; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Sorensen EW; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Mintri S; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Rabideau AE; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Zheng W; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Besin G; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Khatwani N; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Su SV; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Miracco EJ; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Issa WJ; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Hoge S; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Stanton MG; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Joyal JL; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
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Źródło :
Science advances [Sci Adv] 2020 Jun 24; Vol. 6 (26), pp. eaaz6893. Date of Electronic Publication: 2020 Jun 24 (Print Publication: 2020).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
mRNA structure regulates protein expression through changes in functional half-life.
Autorzy :
Mauger DM; Platform Research, Moderna, Inc., Cambridge, MA 02139.
Cabral BJ; Platform Research, Moderna, Inc., Cambridge, MA 02139.
Presnyak V; Platform Research, Moderna, Inc., Cambridge, MA 02139.
Su SV; Platform Research, Moderna, Inc., Cambridge, MA 02139.
Reid DW; Platform Research, Moderna, Inc., Cambridge, MA 02139.
Goodman B; Platform Research, Moderna, Inc., Cambridge, MA 02139.
Link K; Platform Research, Moderna, Inc., Cambridge, MA 02139.
Khatwani N; Platform Research, Moderna, Inc., Cambridge, MA 02139.
Reynders J; Platform Research, Moderna, Inc., Cambridge, MA 02139.
Moore MJ; Platform Research, Moderna, Inc., Cambridge, MA 02139 .
McFadyen IJ; Platform Research, Moderna, Inc., Cambridge, MA 02139.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Nov 26; Vol. 116 (48), pp. 24075-24083. Date of Electronic Publication: 2019 Nov 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Stability*
Protein Biosynthesis/*physiology
RNA, Messenger/*chemistry
Half-Life ; HeLa Cells ; Humans ; Nucleic Acid Conformation ; Proteins/metabolism
Czasopismo naukowe
Tytuł :
Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs.
Autorzy :
Hewitt SL; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
Bai A; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
Bailey D; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
Ichikawa K; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
Zielinski J; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
Karp R; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
Apte A; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
Arnold K; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
Zacharek SJ; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
Iliou MS; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
Bhatt K; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
Garnaas M; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
Musenge F; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
Davis A; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
Khatwani N; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
Su SV; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
MacLean G; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
Farlow SJ; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
Burke K; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA.
Frederick JP; Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA. .
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Źródło :
Science translational medicine [Sci Transl Med] 2019 Jan 30; Vol. 11 (477).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity*
Interleukin-1/*genetics
Interleukin-23/*genetics
Neoplasms/*immunology
OX40 Ligand/*genetics
RNA, Messenger/*administration & dosage
Animals ; Cell Proliferation ; Disease Models, Animal ; Humans ; Inflammation/pathology ; Interleukin-1/metabolism ; Interleukin-23/metabolism ; Lymph Nodes/pathology ; Lymphocyte Activation/immunology ; Mice ; OX40 Ligand/metabolism ; Tissue Distribution ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
Gene set enrichment in eQTL data identifies novel annotations and pathway regulators.
Autorzy :
Wu C; Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America.
Delano DL
Mitro N
Su SV
Janes J
McClurg P
Batalov S
Welch GL
Zhang J
Orth AP
Walker JR
Glynne RJ
Cooke MP
Takahashi JS
Shimomura K
Kohsaka A
Bass J
Saez E
Wiltshire T
Su AI
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Źródło :
PLoS genetics [PLoS Genet] 2008 May 09; Vol. 4 (5), pp. e1000070. Date of Electronic Publication: 2008 May 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :
Genes, Regulator*
Quantitative Trait Loci*
Adipose Tissue/*metabolism
Genomics/*methods
Adipocytes ; Animals ; Cyclin H ; Cyclins/genetics ; Cyclins/metabolism ; Energy Metabolism ; Gene Expression ; Gene Expression Profiling ; Mice ; Mice, Inbred Strains ; Oligonucleotide Array Sequence Analysis ; Polymorphism, Single Nucleotide ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Identification of the optimal DC-SIGN binding site on human immunodeficiency virus type 1 gp120.
Autorzy :
Hong PW; Department of Microbiology, Immunology, and Molecular Genetics, 3825 MSB, UCLA, 609 Charles E. Young Dr. East, Los Angeles, CA 90095, USA.
Nguyen S
Young S
Su SV
Lee B
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Źródło :
Journal of virology [J Virol] 2007 Aug; Vol. 81 (15), pp. 8325-36. Date of Electronic Publication: 2007 May 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Epitopes*
Cell Adhesion Molecules/*metabolism
HIV Envelope Protein gp120/*metabolism
HIV-1/*metabolism
Lectins, C-Type/*metabolism
Receptors, Cell Surface/*metabolism
Binding Sites ; Cell Adhesion Molecules/genetics ; Cell Line ; Glycosylation ; HIV Envelope Protein gp120/chemistry ; HIV Envelope Protein gp120/genetics ; Humans ; Lectins, C-Type/genetics ; Models, Molecular ; Molecular Sequence Data ; Polysaccharides/chemistry ; Polysaccharides/metabolism ; Protein Binding ; Protein Structure, Tertiary ; Receptors, Cell Surface/genetics
Czasopismo naukowe
Tytuł :
N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry.
Autorzy :
Aguilar HC; Department of MIMG, David Geffen Schoo; of Medicine at UCLA, Los Angeles, CA 90095, USA.
Matreyek KA
Filone CM
Hashimi ST
Levroney EL
Negrete OA
Bertolotti-Ciarlet A
Choi DY
McHardy I
Fulcher JA
Su SV
Wolf MC
Kohatsu L
Baum LG
Lee B
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Źródło :
Journal of virology [J Virol] 2006 May; Vol. 80 (10), pp. 4878-89.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Membrane Fusion/*physiology
Nipah Virus/*physiology
Polysaccharides/*physiology
Viral Envelope Proteins/*physiology
Viral Fusion Proteins/*physiology
Animals ; Cell Line ; Dogs ; Glycosylation ; HeLa Cells ; Henipavirus Infections/prevention & control ; Henipavirus Infections/virology ; Humans ; Membrane Fusion/genetics ; Neutralization Tests ; Nipah Virus/genetics ; Nipah Virus/pathogenicity ; Polysaccharides/genetics ; Polysaccharides/metabolism ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/metabolism ; Viral Fusion Proteins/biosynthesis ; Viral Fusion Proteins/genetics ; Viral Fusion Proteins/metabolism
Czasopismo naukowe
Tytuł :
Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus.
Autorzy :
Negrete OA; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, California, USA.
Wolf MC
Aguilar HC
Enterlein S
Wang W
Mühlberger E
Su SV
Bertolotti-Ciarlet A
Flick R
Lee B
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Źródło :
PLoS pathogens [PLoS Pathog] 2006 Feb; Vol. 2 (2), pp. e7. Date of Electronic Publication: 2006 Feb 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Ephrin-B3/*chemistry
Ephrin-B3/*metabolism
Nipah Virus/*metabolism
Receptors, Virus/*metabolism
Animals ; Binding Sites ; CHO Cells ; Cricetinae ; Cricetulus ; Ephrin-B2/genetics ; Ephrin-B2/metabolism ; Ephrin-B3/genetics ; Henipavirus Infections/virology ; Humans ; Leucine ; Nipah Virus/physiology ; Tryptophan
Czasopismo naukowe
    Wyświetlanie 1-11 z 11

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