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Wyszukujesz frazę ""Substantia Nigra"" wg kryterium: Temat


Tytuł :
Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development.
Autorzy :
Brignani S; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.
Raj DDA; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.
Schmidt ERE; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.
Düdükcü Ö; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.
Adolfs Y; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.
De Ruiter AA; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.
Rybiczka-Tesulov M; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.
Verhagen MG; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.
van der Meer C; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.
Broekhoven MH; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.
Moreno-Bravo JA; Institut de la Vision, Sorbonne Université, INSERM, CNRS, 17 Rue Moreau, 75012 Paris, France.
Grossouw LM; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.
Dumontier E; Montreal Neurological Institute, 3801 University, Montréal, QC H3A 2B4, Canada.
Cloutier JF; Montreal Neurological Institute, 3801 University, Montréal, QC H3A 2B4, Canada.
Chédotal A; Institut de la Vision, Sorbonne Université, INSERM, CNRS, 17 Rue Moreau, 75012 Paris, France.
Pasterkamp RJ; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Aug 19; Vol. 107 (4), pp. 684-702.e9. Date of Electronic Publication: 2020 Jun 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Movement/*physiology
Dopaminergic Neurons/*metabolism
GABAergic Neurons/*metabolism
Netrin-1/*metabolism
Prosencephalon/*metabolism
Substantia Nigra/*metabolism
Animals ; Axons/metabolism ; Dopaminergic Neurons/cytology ; GABAergic Neurons/cytology ; Mice ; Mice, Transgenic ; Substantia Nigra/cytology
Czasopismo naukowe
Tytuł :
Impaired glymphatic system in secondary degeneration areas after ischemic stroke in rats.
Autorzy :
Lin L; Department of Radiology, Huashan Hospital, Fudan University, No. 12 Middle Urumqi Road, Shanghai 200040, China.
Hao X; Department of Radiology, Huashan Hospital, Fudan University, No. 12 Middle Urumqi Road, Shanghai 200040, China.
Li C; Department of Radiology, Huashan Hospital, Fudan University, No. 12 Middle Urumqi Road, Shanghai 200040, China.
Sun C; Department of Radiology, Huashan Hospital, Fudan University, No. 12 Middle Urumqi Road, Shanghai 200040, China.
Wang X; Department of Radiology, Huashan Hospital, Fudan University, No. 12 Middle Urumqi Road, Shanghai 200040, China.
Yin L; Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhang X; Department of Radiotherapy, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Tian J; Department of Radiology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Yang Y; Department of Radiology, Huashan Hospital, Fudan University, No. 12 Middle Urumqi Road, Shanghai 200040, China. Electronic address: .
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Źródło :
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2020 Jul; Vol. 29 (7), pp. 104828. Date of Electronic Publication: 2020 May 11.
Typ publikacji :
Journal Article
MeSH Terms :
Magnetic Resonance Imaging*
Nerve Degeneration*
Contrast Media/*administration & dosage
Gadolinium DTPA/*administration & dosage
Glymphatic System/*diagnostic imaging
Infarction, Middle Cerebral Artery/*diagnostic imaging
Substantia Nigra/*diagnostic imaging
Ventral Thalamic Nuclei/*diagnostic imaging
Animals ; Disease Models, Animal ; Glymphatic System/pathology ; Glymphatic System/physiopathology ; Infarction, Middle Cerebral Artery/pathology ; Infarction, Middle Cerebral Artery/physiopathology ; Male ; Predictive Value of Tests ; Rats, Sprague-Dawley ; Signal-To-Noise Ratio ; Substantia Nigra/pathology ; Substantia Nigra/physiopathology ; Time Factors ; Ventral Thalamic Nuclei/pathology ; Ventral Thalamic Nuclei/physiopathology
Czasopismo naukowe
Tytuł :
A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders.
Autorzy :
Agarwal D; Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.; Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy, Genetics, University of Oxford, Oxford, UK.
Sandor C; UK Dementia Research Institute, Cardiff University, Cardiff, UK.
Volpato V; UK Dementia Research Institute, Cardiff University, Cardiff, UK.
Caffrey TM; Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy, Genetics, University of Oxford, Oxford, UK.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Monzón-Sandoval J; UK Dementia Research Institute, Cardiff University, Cardiff, UK.
Bowden R; Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX2 7BN, UK.
Alegre-Abarrategui J; Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy, Genetics, University of Oxford, Oxford, UK.; Department of Neuropathology, University of Oxford, Oxford, UK.; Division of Brain Sciences, Imperial College London, London, UK.
Wade-Martins R; Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy, Genetics, University of Oxford, Oxford, UK.
Webber C; Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy, Genetics, University of Oxford, Oxford, UK. .; UK Dementia Research Institute, Cardiff University, Cardiff, UK. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 21; Vol. 11 (1), pp. 4183. Date of Electronic Publication: 2020 Aug 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression*
Nervous System Diseases/*genetics
Nervous System Diseases/*metabolism
Parkinson Disease/*genetics
Parkinson Disease/*metabolism
Substantia Nigra/*metabolism
Alzheimer Disease/metabolism ; Astrocytes/metabolism ; Brain ; Dopaminergic Neurons/metabolism ; Humans ; Microglia/metabolism ; Mitochondria/metabolism ; Nervous System Diseases/pathology ; Substantia Nigra/pathology ; Transcriptome
Czasopismo naukowe
Tytuł :
"The One Who Guides" Nigral Neuron Migration.
Autorzy :
Awatramani R; Northwestern University, Department of Neurology, Chicago, IL 60611, USA. Electronic address: .
Lévesque M; Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval, CERVO Brain Research Centre, 2601 Chemin de la Canardiere, Quebec, QC, Canada.
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Źródło :
Neuron [Neuron] 2020 Aug 19; Vol. 107 (4), pp. 595-596.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
GABAergic Neurons*
Substantia Nigra*
Axons ; Dopamine ; Netrin-1
Czasopismo naukowe
Tytuł :
Amygdala-Midbrain Connections Modulate Appetitive and Aversive Learning.
Autorzy :
Steinberg EE; Nancy Pritzker Laboratory, Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Gore F; Nancy Pritzker Laboratory, Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Departments of Bioengineering and Psychiatry and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Heifets BD; Nancy Pritzker Laboratory, Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Department of Anesthesiology, Stanford University, Stanford, CA 94305, USA.
Taylor MD; Nancy Pritzker Laboratory, Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Norville ZC; Nancy Pritzker Laboratory, Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Beier KT; Nancy Pritzker Laboratory, Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Department of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Földy C; Nancy Pritzker Laboratory, Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Brain Research Institute, University of Zurich, Zurich, Switzerland.
Lerner TN; Departments of Bioengineering and Psychiatry and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Luo L; Department of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Deisseroth K; Departments of Bioengineering and Psychiatry and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Malenka RC; Nancy Pritzker Laboratory, Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA 94305, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Jun 17; Vol. 106 (6), pp. 1026-1043.e9. Date of Electronic Publication: 2020 Apr 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Appetitive Behavior/*physiology
Avoidance Learning/*physiology
Central Amygdaloid Nucleus/*physiology
Dopaminergic Neurons/*physiology
GABAergic Neurons/*physiology
Substantia Nigra/*physiology
Animals ; Conditioning, Classical/physiology ; Emotions ; Mice ; Neural Pathways ; Reinforcement, Psychology ; Reward ; Substantia Nigra/cytology
Czasopismo naukowe
Tytuł :
Reversing a model of Parkinson's disease with in situ converted nigral neurons.
Autorzy :
Qian H; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Kang X; State Key Laboratory of Membrane Biology and Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing, China.; MOE Key Lab of Medical Electrophysiology, ICR, Southwest Medical University, Luzhou, China.
Hu J; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.; Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Zhang D; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.
Liang Z; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Meng F; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Zhang X; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Xue Y; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.; Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Maimon R; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.; Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA.
Dowdy SF; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Devaraj NK; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.
Zhou Z; State Key Laboratory of Membrane Biology and Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing, China.
Mobley WC; Department of Neurosciences and Center for Neural Circuits and Behavior, University of California, San Diego, La Jolla, CA, USA.
Cleveland DW; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.; Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA.
Fu XD; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA. .; Institute of Genomic Medicine, University of California, San Diego, La Jolla, CA, USA. .
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Źródło :
Nature [Nature] 2020 Jun; Vol. 582 (7813), pp. 550-556. Date of Electronic Publication: 2020 Jun 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Astrocytes/*cytology
Dopaminergic Neurons/*cytology
Parkinson Disease/*pathology
Parkinson Disease/*therapy
Substantia Nigra/*cytology
Substantia Nigra/*physiology
Animals ; Axons/physiology ; Dopamine/biosynthesis ; Dopamine/metabolism ; Dopaminergic Neurons/metabolism ; Female ; Heterogeneous-Nuclear Ribonucleoproteins/deficiency ; Heterogeneous-Nuclear Ribonucleoproteins/genetics ; Heterogeneous-Nuclear Ribonucleoproteins/metabolism ; Humans ; In Vitro Techniques ; Male ; Mice ; Neostriatum/cytology ; Neostriatum/physiology ; Neural Pathways ; Neurogenesis ; Parkinson Disease/metabolism ; Phenotype ; Polypyrimidine Tract-Binding Protein/deficiency ; Polypyrimidine Tract-Binding Protein/genetics ; Polypyrimidine Tract-Binding Protein/metabolism ; Substantia Nigra/metabolism
Czasopismo naukowe
Tytuł :
Alpha-Synuclein deficiency ameliorates chronic methamphetamine induced neurodegeneration in mice.
Autorzy :
Ding J; School of Forensic Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China.
Hu S; Good Clinical Practice Center, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou, China.
Meng Y; School of Forensic Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China.
Li C; School of Forensic Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China.
Huang J; School of Forensic Medicine, Kunming Medical University, Kunming 650000, Yunnan, China.
He Y; School of Forensic Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China.
Qiu P; School of Forensic Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China. Electronic address: .
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Źródło :
Toxicology [Toxicology] 2020 May 30; Vol. 438, pp. 152461. Date of Electronic Publication: 2020 Apr 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nerve Degeneration*
Hippocampus/*metabolism
Neurons/*metabolism
Neurotoxicity Syndromes/*prevention & control
Substantia Nigra/*metabolism
alpha-Synuclein/*deficiency
Animals ; Autophagy ; Axons/metabolism ; Axons/ultrastructure ; Cells, Cultured ; Cyclin-Dependent Kinase 5/metabolism ; Disease Models, Animal ; Glycogen Synthase Kinase 3 beta/metabolism ; Hippocampus/ultrastructure ; Lysosomes/metabolism ; Lysosomes/ultrastructure ; Male ; Methamphetamine ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria/metabolism ; Mitochondria/ultrastructure ; Neurons/ultrastructure ; Neurotoxicity Syndromes/genetics ; Neurotoxicity Syndromes/metabolism ; Neurotoxicity Syndromes/pathology ; Phosphorylation ; Substantia Nigra/ultrastructure ; Time Factors ; alpha-Synuclein/genetics ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Human decisions about when to act originate within a basal forebrain-nigral circuit.
Autorzy :
Khalighinejad N; Wellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford OX1 3SR, United Kingdom; .
Priestley L; Wellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford OX1 3SR, United Kingdom.
Jbabdi S; Wellcome Centre for Integrative Neuroimaging, Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.
Rushworth MFS; Wellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford OX1 3SR, United Kingdom.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 May 26; Vol. 117 (21), pp. 11799-11810. Date of Electronic Publication: 2020 May 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Basal Forebrain/*physiology
Decision Making/*physiology
Substantia Nigra/*physiology
Adult ; Basal Forebrain/diagnostic imaging ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Models, Neurological ; Nerve Net/diagnostic imaging ; Nerve Net/physiology ; Substantia Nigra/diagnostic imaging
Czasopismo naukowe
Tytuł :
Do the Magic Angle Effects or Susceptibility Effects Affect the Visualization of Nigrosome 1?
Autorzy :
Kim EY; Department of RadiologyGil Medical CenterGachon University College of MedicineIncheon, South Korea.
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Źródło :
AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2020 Apr; Vol. 41 (4), pp. E20. Date of Electronic Publication: 2020 Mar 05.
Typ publikacji :
Letter; Comment
MeSH Terms :
Parkinson Disease*
Substantia Nigra*
Humans
Opinia redakcyjna
Tytuł :
Network degeneration in Parkinson's disease: multimodal imaging of nigro-striato-cortical dysfunction.
Autorzy :
Ruppert MC; Department of Neurology, University Hospital of Marburg, Germany.; Center for Mind, Brain and Behavior - CMBB, Universities Marburg and Gießen, Germany.
Greuel A; Department of Neurology, University Hospital of Marburg, Germany.
Tahmasian M; Institue of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran.
Schwartz F; Department of Neurology, Hospital of the Brothers of Mercy, Trier, Germany.
Stürmer S; Max Planck Institute for Metabolism Research, Cologne, Germany.; Department of Neurology, Medical Faculty and University Hospital Cologne, University Hospital Cologne, Germany.
Maier F; Department of Psychiatry, University Hospital Cologne, Medical Faculty, Cologne, Germany.
Hammes J; Multimodal Neuroimaging Group, Department of Nuclear Medicine, Medical Faculty and University Hospital Cologne, University Hospital Cologne, Germany.
Tittgemeyer M; Max Planck Institute for Metabolism Research, Cologne, Germany.; Cluster of Excellence in Cellular Stress and Aging Associated Disease (CECAD), Cologne, Germany.
Timmermann L; Department of Neurology, University Hospital of Marburg, Germany.; Center for Mind, Brain and Behavior - CMBB, Universities Marburg and Gießen, Germany.
van Eimeren T; Department of Neurology, Medical Faculty and University Hospital Cologne, University Hospital Cologne, Germany.; Multimodal Neuroimaging Group, Department of Nuclear Medicine, Medical Faculty and University Hospital Cologne, University Hospital Cologne, Germany.; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Germany.
Drzezga A; Multimodal Neuroimaging Group, Department of Nuclear Medicine, Medical Faculty and University Hospital Cologne, University Hospital Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE), Germany.; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-2), Research Center Jülich, Germany.
Eggers C; Department of Neurology, University Hospital of Marburg, Germany.; Center for Mind, Brain and Behavior - CMBB, Universities Marburg and Gießen, Germany.
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Źródło :
Brain : a journal of neurology [Brain] 2020 Mar 01; Vol. 143 (3), pp. 944-959.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebral Cortex/*physiopathology
Corpus Striatum/*physiopathology
Parkinson Disease/*physiopathology
Substantia Nigra/*physiopathology
Aged ; Case-Control Studies ; Cerebral Cortex/metabolism ; Corpus Striatum/metabolism ; Dihydroxyphenylalanine/analogs & derivatives ; Dihydroxyphenylalanine/metabolism ; Dopamine/metabolism ; Female ; Fluorodeoxyglucose F18/metabolism ; Functional Neuroimaging ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multimodal Imaging ; Neural Pathways/physiopathology ; Parkinson Disease/metabolism ; Positron-Emission Tomography ; Putamen/physiopathology ; Substantia Nigra/metabolism
Czasopismo naukowe
Tytuł :
Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging.
Autorzy :
Matuskey D; Positron Emission Tomography Research Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT.; Department of Psychiatry, Yale University, New Haven, CT.; Department of Neurology, Yale University, New Haven, CT.
Tinaz S; Department of Neurology, Yale University, New Haven, CT.
Wilcox KC; Translational Imaging, Integrated Science and Technology, AbbVie, North Chicago, IL.
Naganawa M; Positron Emission Tomography Research Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT.
Toyonaga T; Positron Emission Tomography Research Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT.
Dias M; Positron Emission Tomography Research Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT.
Henry S; Positron Emission Tomography Research Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT.
Pittman B; Department of Psychiatry, Yale University, New Haven, CT.
Ropchan J; Positron Emission Tomography Research Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT.
Nabulsi N; Positron Emission Tomography Research Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT.
Suridjan I; Translational Imaging, Integrated Science and Technology, AbbVie, North Chicago, IL.
Comley RA; Translational Imaging, Integrated Science and Technology, AbbVie, North Chicago, IL.
Huang Y; Positron Emission Tomography Research Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT.
Finnema SJ; Positron Emission Tomography Research Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT.; Translational Imaging, Integrated Science and Technology, AbbVie, North Chicago, IL.
Carson RE; Positron Emission Tomography Research Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT.
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Źródło :
Annals of neurology [Ann Neurol] 2020 Mar; Vol. 87 (3), pp. 329-338. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Journal Article
MeSH Terms :
Early Diagnosis*
Parkinson Disease/*diagnostic imaging
Parkinson Disease/*pathology
Putamen/*pathology
Substantia Nigra/*pathology
Synapses/*pathology
Autoradiography ; Case-Control Studies ; Female ; Functional Neuroimaging ; Humans ; Locus Coeruleus/pathology ; Male ; Membrane Glycoproteins/metabolism ; Middle Aged ; Nerve Tissue Proteins/metabolism ; Positron-Emission Tomography ; Putamen/metabolism ; Pyridines ; Pyrrolidines ; Red Nucleus/pathology ; Substantia Nigra/metabolism
Czasopismo naukowe
Tytuł :
A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy.
Autorzy :
Chen B; Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Xu C; Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Wang Y; Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. .; Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. .
Lin W; Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Wang Y; Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Chen L; Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Cheng H; Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Xu L; Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Hu T; Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Zhao J; Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Dong P; Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Guo Y; Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zhang S; Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Wang S; Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zhou Y; Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Hu W; Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Duan S; Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Chen Z; Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. .; Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. .; College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, China. .
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Źródło :
Nature communications [Nat Commun] 2020 Feb 17; Vol. 11 (1), pp. 923. Date of Electronic Publication: 2020 Feb 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epilepsy, Temporal Lobe/*physiopathology
Intralaminar Thalamic Nuclei/*physiopathology
Neural Pathways/*physiopathology
Substantia Nigra/*physiopathology
Animals ; Disease Models, Animal ; Electrodes, Implanted ; Epilepsy, Temporal Lobe/diagnosis ; GABAergic Neurons/physiology ; Humans ; Intralaminar Thalamic Nuclei/cytology ; Male ; Mice ; Mice, Transgenic ; Optogenetics ; Patch-Clamp Techniques ; Severity of Illness Index ; Stereotaxic Techniques ; Substantia Nigra/cytology
Czasopismo naukowe
Tytuł :
The stillness of sleep.
Autorzy :
Wisden W; Department of Life Science and UK Dementia Research Institute at Imperial College London, London, UK. .
Franks NP; Department of Life Science and UK Dementia Research Institute at Imperial College London, London, UK. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Jan 24; Vol. 367 (6476), pp. 366-367.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Sleep*
Substantia Nigra*
Czasopismo naukowe
Tytuł :
Acupuncture Inhibits the Increase in Alpha-Synuclein in Substantia Nigra in an MPTP- Induced Parkinsonism Mouse Model.
Autorzy :
Yeo S; College of Korean Medicine, Sang Ji University, Wonju, Republic of Korea. .
Song J; College of Korean Medicine, Sang Ji University, Wonju, Republic of Korea.
Lim S; Department of Meridian & Acupoint, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
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Źródło :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2020; Vol. 1232, pp. 401-408.
Typ publikacji :
Journal Article
MeSH Terms :
Acupuncture Therapy*
Parkinsonian Disorders*/chemically induced
Substantia Nigra*/metabolism
alpha-Synuclein*/metabolism
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Animals ; Disease Models, Animal ; Dopaminergic Neurons/pathology ; Mice ; Mice, Inbred C57BL ; Neuroprotective Agents ; Tyrosine 3-Monooxygenase/metabolism
Czasopismo naukowe
Tytuł :
Signal Alteration of Substantia Nigra on 3.0T Susceptibility-weighted Imaging in Parkinson's Disease and Vascular Parkinsonism.
Autorzy :
Zhao XJ; Neurocritical Care Unit, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.
Niu XY; Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.
You HY; Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.
Zhou M; Neurocritical Care Unit, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.
Ji XB; Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.
Liu Y; Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.
Wu L; Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China. .
Ding XL; Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China. .
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Źródło :
Current medical science [Curr Med Sci] 2019 Oct; Vol. 39 (5), pp. 831-835. Date of Electronic Publication: 2019 Oct 14.
Typ publikacji :
Journal Article
MeSH Terms :
Dementia, Multi-Infarct/*diagnostic imaging
Magnetic Resonance Imaging/*statistics & numerical data
Parkinson Disease/*diagnostic imaging
Substantia Nigra/*diagnostic imaging
Aged ; Aged, 80 and over ; Biomarkers/analysis ; Case-Control Studies ; Dementia, Multi-Infarct/pathology ; Diagnosis, Differential ; Female ; Humans ; Male ; Middle Aged ; Parkinson Disease/pathology ; Sensitivity and Specificity ; Substantia Nigra/blood supply ; Substantia Nigra/pathology
Czasopismo naukowe
Tytuł :
3 versus 7 Tesla magnetic resonance imaging for parcellations of subcortical brain structures in clinical settings.
Autorzy :
Isaacs, Bethany R. (AUTHOR)
Mulder, Martijn J. (AUTHOR)
Groot, Josephine M. (AUTHOR)
van Berendonk, Nikita (AUTHOR)
Lute, Nicky (AUTHOR)
Bazin, Pierre-Louis (AUTHOR)
Forstmann, Birte U. (AUTHOR)
Alkemade, Anneke (AUTHOR)
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Źródło :
PLoS ONE. 11/24/2020, Vol. 15 Issue 11, p1-21. 21p.
Czasopismo naukowe
Tytuł :
Intranigral Administration of β-Sitosterol-β-D-Glucoside Elicits Neurotoxic A1 Astrocyte Reactivity and Chronic Neuroinflammation in the Rat Substantia Nigra.
Autorzy :
Luna-Herrera, Claudia (AUTHOR)
Martínez-Dávila, Irma A. (AUTHOR)
Soto-Rojas, Luis O. (AUTHOR)
Flores-Martinez, Yazmin M. (AUTHOR)
Fernandez-Parrilla, Manuel A. (AUTHOR)
Ayala-Davila, Jose (AUTHOR)
León-Chavez, Bertha A. (AUTHOR)
Soto-Rodriguez, Guadalupe (AUTHOR)
Blanco-Alvarez, Victor M. (AUTHOR)
Lopez-Salas, Francisco E. (AUTHOR)
Gutierrez-Castillo, Maria E. (AUTHOR)
Gatica-Garcia, Bismark (AUTHOR)
Padilla-Viveros, America (AUTHOR)
Bañuelos, Cecilia (AUTHOR)
Reyes-Corona, David (AUTHOR)
Espadas-Alvarez, Armando J. (AUTHOR)
Garcés-Ramírez, Linda (AUTHOR)
Hidalgo-Alegria, Oriana (AUTHOR)
De La Cruz-lópez, Fidel (AUTHOR)
Martinez-Fong, Daniel (AUTHOR)
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Źródło :
Journal of Immunology Research. 11/23/2020, p1-19. 19p. 2 Color Photographs, 8 Graphs.
Czasopismo naukowe
Tytuł :
Unilateral Optogenetic Inhibition and Excitation of Basal Ganglia Output Affect Directional Lick Choices and Movement Initiation in Mice.
Autorzy :
Morrissette AE; Department of Biology, Emory University, Atlanta, GA, United States.
Chen PH; Department of Biology, Emory University, Atlanta, GA, United States.
Bhamani C; Cornell University, Ithaca, NY, United States.
Borden PY; Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, United States.
Waiblinger C; Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, United States.
Stanley GB; Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, United States.
Jaeger D; Department of Biology, Emory University, Atlanta, GA, United States. Electronic address: .
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Źródło :
Neuroscience [Neuroscience] 2019 Dec 15; Vol. 423, pp. 55-65. Date of Electronic Publication: 2019 Nov 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Basal Ganglia/*physiology
Decision Making/*physiology
Movement/*physiology
Neural Inhibition/*physiology
Substantia Nigra/*physiology
Animals ; Anticipation, Psychological/drug effects ; Behavior, Animal/drug effects ; Dependovirus/genetics ; Female ; Functional Laterality/physiology ; Male ; Mice ; Motor Cortex/physiology ; Neural Pathways/physiology ; Optogenetics ; Substantia Nigra/drug effects ; Thalamus/physiology ; Vesicular Inhibitory Amino Acid Transport Proteins/genetics
Czasopismo naukowe
Tytuł :
Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice.
Autorzy :
Earls RH; Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, GA, 30602, USA.
Menees KB; Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, GA, 30602, USA.
Chung J; Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, GA, 30602, USA.
Barber J; Department of Infectious Disease, University of Georgia College of Veterinary Medicine, Athens, GA, 30602, USA.
Gutekunst CA; Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Hazim MG; Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Lee JK; Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, GA, 30602, USA. .
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Źródło :
Journal of neuroinflammation [J Neuroinflammation] 2019 Dec 03; Vol. 16 (1), pp. 250. Date of Electronic Publication: 2019 Dec 03.
Typ publikacji :
Journal Article
MeSH Terms :
Immunity, Cellular/*immunology
Substantia Nigra/*immunology
T-Lymphocytes/*immunology
alpha-Synuclein/*administration & dosage
Animals ; Animals, Newborn ; Cells, Cultured ; Female ; Humans ; Immunity, Cellular/drug effects ; Injections, Intraventricular ; Male ; Mice ; Mice, Inbred C57BL ; Substantia Nigra/drug effects ; Substantia Nigra/metabolism ; T-Lymphocytes/drug effects ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
Convolutional neural network-based segmentation can help in assessing the substantia nigra in neuromelanin MRI.
Autorzy :
Le Berre A; Department of Radiology, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.; Department of Radiology, Université Paris Descartes, 12 rue de l'Ecole de Medecine, 75006, Paris, France.
Kamagata K; Department of Radiology, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. .
Otsuka Y; Department of Radiology, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.; Milliman Inc., Tokyo, Japan.
Andica C; Department of Radiology, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Hatano T; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Saccenti L; Department of Radiology, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.; Department of Radiology, Université Paris Descartes, 12 rue de l'Ecole de Medecine, 75006, Paris, France.
Ogawa T; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Takeshige-Amano H; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Wada A; Department of Radiology, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Suzuki M; Department of Radiology, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Hagiwara A; Department of Radiology, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Irie R; Department of Radiology, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Hori M; Department of Radiology, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Oyama G; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Shimo Y; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Umemura A; Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan.
Hattori N; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Aoki S; Department of Radiology, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
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Źródło :
Neuroradiology [Neuroradiology] 2019 Dec; Vol. 61 (12), pp. 1387-1395. Date of Electronic Publication: 2019 Aug 10.
Typ publikacji :
Journal Article
MeSH Terms :
Image Interpretation, Computer-Assisted/*methods
Magnetic Resonance Imaging/*methods
Melanins/*metabolism
Parkinson Disease/*diagnostic imaging
Substantia Nigra/*diagnostic imaging
Aged ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Neural Networks, Computer ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Retrospective Studies ; Substantia Nigra/metabolism ; Substantia Nigra/pathology
Czasopismo naukowe

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