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Tytuł :
DNA surface exploration and operator bypassing during target search.
Autorzy :
Marklund E; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
van Oosten B; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Mao G; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Amselem E; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Kipper K; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Sabantsev A; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Emmerich A; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Globisch D; Department of Medicinal Chemistry, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Zheng X; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Lehmann LC; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Berg OG; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Johansson M; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Elf J; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. .
Deindl S; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. .
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Źródło :
Nature [Nature] 2020 Jul; Vol. 583 (7818), pp. 858-861. Date of Electronic Publication: 2020 Jun 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nucleic Acid Conformation*
Substrate Specificity*/genetics
DNA/*chemistry
Operator Regions, Genetic/*genetics
Binding Sites/genetics ; DNA/genetics ; Diffusion ; Fluorescence Resonance Energy Transfer ; Kinetics ; Lac Repressors/metabolism ; Protein Binding ; Rotation ; Single Molecule Imaging ; Spectrometry, Fluorescence
Czasopismo naukowe
Tytuł :
A novel carcinogenic PI3Kα mutation suggesting the role of helical domain in transmitting nSH2 regulatory signals to kinase domain.
Autorzy :
Ghalamkari S; Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran.
Alavi S; Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Mianesaz H; Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran.
Khosravian F; Cellular, Molecular and Genetics Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Medical Genetics Research Center of Genome, Isfahan University of Medical Sciences, Isfahan, Iran.
Bahreini A; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA, USA; KaryoGen, Isfahan, Iran. Electronic address: .
Salehi M; Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran; Cellular, Molecular and Genetics Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Medical Genetics Research Center of Genome, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Mar 15; Vol. 269, pp. 118759. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Carcinogenesis/*genetics
Class I Phosphatidylinositol 3-Kinases/*chemistry
Class I Phosphatidylinositol 3-Kinases/*genetics
Mutation/*genetics
Adult ; Allosteric Regulation ; Biocatalysis ; Exons/genetics ; Female ; Humans ; Middle Aged ; Mutant Proteins/chemistry ; Mutant Proteins/metabolism ; Protein Domains ; Protein Structure, Secondary ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Metabolism and pharmacokinetics of pharmaceuticals in cats (Felix sylvestris catus) and implications for the risk assessment of feed additives and contaminants.
Autorzy :
Lautz LS; Radboud University Nijmegen, Houtlaan 4, 6525 XZ Nijmegen, the Netherlands.
Jeddi MZ; European Food Safety Authority, Scientific Committee and Emerging Risks Unit, Via Carlo Magno, 1A, 43126 Parma, Italy.
Girolami F; University of Torino, Department of Veterinary Sciences, Largo P. Braccini 2, 10095 Grugliasco, Italy.
Nebbia C; University of Torino, Department of Veterinary Sciences, Largo P. Braccini 2, 10095 Grugliasco, Italy.
Dorne JLCM; European Food Safety Authority, Scientific Committee and Emerging Risks Unit, Via Carlo Magno, 1A, 43126 Parma, Italy. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Mar 01; Vol. 338, pp. 114-127. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Comparative Study; Journal Article; Review
MeSH Terms :
Food Contamination*
Animal Feed/*toxicity
Cytochrome P-450 Enzyme System/*metabolism
Glucuronosyltransferase/*metabolism
Xenobiotics/*pharmacokinetics
Animals ; Cats ; Metabolic Detoxication, Phase I ; Metabolic Detoxication, Phase II ; No-Observed-Adverse-Effect Level ; Rats ; Risk Assessment ; Species Specificity ; Substrate Specificity ; Uncertainty ; Xenobiotics/administration & dosage ; Xenobiotics/toxicity
Czasopismo naukowe
Tytuł :
Meloxicam methyl group determines enzyme specificity for thiazole bioactivation compared to sudoxicam.
Autorzy :
Barnette DA; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205, United States.
Schleiff MA; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205, United States.
Datta A; Department of Pathology and Immunology, 660 S Euclid Ave, Washington University, St. Louis, MO, 63130, United States.
Flynn N; Department of Pathology and Immunology, 660 S Euclid Ave, Washington University, St. Louis, MO, 63130, United States.
Swamidass SJ; Department of Pathology and Immunology, 660 S Euclid Ave, Washington University, St. Louis, MO, 63130, United States.
Miller GP; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205, United States. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Mar 01; Vol. 338, pp. 10-20. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*metabolism
Cytochrome P-450 CYP1A2/*metabolism
Cytochrome P-450 CYP2C8/*metabolism
Cytochrome P-450 CYP2C9/*metabolism
Meloxicam/*metabolism
Microsomes, Liver/*enzymology
Thiazines/*metabolism
Activation, Metabolic ; Anti-Inflammatory Agents, Non-Steroidal/toxicity ; Chemical and Drug Induced Liver Injury/etiology ; Data Mining ; Deep Learning ; Drug Interactions ; Electronic Health Records ; Female ; Humans ; Inactivation, Metabolic ; Kinetics ; Male ; Meloxicam/toxicity ; Middle Aged ; Substrate Specificity ; Thiazines/toxicity
Czasopismo naukowe
Tytuł :
Protein structural heterogeneity: A hypothesis for the basis of proteolytic recognition by the main protease of SARS-CoV and SARS-CoV-2.
Autorzy :
Behnam MAM; Institute of Pharmacy and Molecular Biotechnology, Im Neuenheimer Feld 364, 69120, Heidelberg, Germany. Electronic address: .
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Źródło :
Biochimie [Biochimie] 2021 Mar; Vol. 182, pp. 177-184. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Conformation*
COVID-19/*virology
SARS Virus/*enzymology
SARS-CoV-2/*enzymology
Viral Proteases/*chemistry
Viral Proteases/*metabolism
Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Catalytic Domain ; Drug Design ; Humans ; Protease Inhibitors/chemistry ; Protease Inhibitors/metabolism ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Effects of conserved Arg20, Glu74 and Asp77 on the structure and function of a tau class glutathione S-transferase in rice.
Autorzy :
Yang X; College of Life Sciences, Jilin Agricultural University, Changchun, 130118, China.; State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, The Chinese Academy of Sciences, Beijing, 100093, China.
Wu Z; College of Life Sciences, Jilin Agricultural University, Changchun, 130118, China. .
Gao J; CAS Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun, 666303, Yunnan, China. .; Center of Conservation Biology, Core Botanical Gardens, Chinese Academy of Sciences, Mengla, 666303, China. .
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Źródło :
Plant molecular biology [Plant Mol Biol] 2021 Mar; Vol. 105 (4-5), pp. 451-462. Date of Electronic Publication: 2021 Jan 02.
Typ publikacji :
Journal Article
MeSH Terms :
Catalytic Domain*
Amino Acids/*genetics
Glutathione Transferase/*genetics
Oryza/*genetics
Plant Proteins/*genetics
Amino Acid Sequence ; Amino Acids/chemistry ; Amino Acids/metabolism ; Arginine/chemistry ; Arginine/genetics ; Arginine/metabolism ; Aspartic Acid/chemistry ; Aspartic Acid/genetics ; Aspartic Acid/metabolism ; Enzyme Stability/genetics ; Glutamic Acid/chemistry ; Glutamic Acid/genetics ; Glutamic Acid/metabolism ; Glutathione/metabolism ; Glutathione Transferase/chemistry ; Glutathione Transferase/metabolism ; Models, Molecular ; Mutation ; Oryza/enzymology ; Plant Proteins/chemistry ; Plant Proteins/metabolism ; Protein Domains ; Sequence Homology, Amino Acid ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Characterization of a Rhodobacter sphaeroides primary fatty acid kinase.
Autorzy :
Bachochin MJ; Department of Biological Sciences, College of Natural and Health Sciences, University of Wisconsin-Parkside, 900 Wood Rd, Kenosha, WI, 53141-2000, USA.
Van Allen M; Department of Biological Sciences, College of Natural and Health Sciences, University of Wisconsin-Parkside, 900 Wood Rd, Kenosha, WI, 53141-2000, USA.
Barber RD; Department of Biological Sciences, College of Natural and Health Sciences, University of Wisconsin-Parkside, 900 Wood Rd, Kenosha, WI, 53141-2000, USA. .
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Źródło :
Archives of microbiology [Arch Microbiol] 2021 Mar; Vol. 203 (2), pp. 861-864. Date of Electronic Publication: 2020 Oct 10.
Typ publikacji :
Journal Article
MeSH Terms :
Acetate Kinase/*metabolism
Rhodobacter sphaeroides/*enzymology
Acyl Coenzyme A/metabolism ; Acyltransferases/metabolism ; Fatty Acids/metabolism ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Molecular biology interventions for activity improvement and production of industrial enzymes.
Autorzy :
Kant Bhatia S; Department of Biological Engineering, College of Engineering, Konkuk University, Seoul 05029, Republic of Korea; Institute for Ubiquitous Information Technology and Application, Konkuk University, Seoul 05029, Republic of Korea.
Vivek N; Centre for Climate and Environmental Protection, School of Water, Energy and Environment, Cranfield University, Cranfield MK43 0AL, UK.
Kumar V; Centre for Climate and Environmental Protection, School of Water, Energy and Environment, Cranfield University, Cranfield MK43 0AL, UK.
Chandel N; School of Medical and Allied Sciences, GD Goenka University, Gurugram 122103, Haryana, India.
Thakur M; Department of Biotechnology, Shoolini Institute of Life Sciences and Business Management, Solan 173212, Himachal Pradesh, India.
Kumar D; School of Bioengineering & Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan 173229, Himachal Pradesh, India.
Yang YH; Department of Biological Engineering, College of Engineering, Konkuk University, Seoul 05029, Republic of Korea; Institute for Ubiquitous Information Technology and Application, Konkuk University, Seoul 05029, Republic of Korea.
Pugazendhi A; Innovative Green Product Synthesis and Renewable Environment Development Research Group, Faculty of Environment and Labour Safety, Ton Duc Thang University, Ho ChiMinh City, Viet Nam.
Kumar G; Institute of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Box 8600 Forus, 4036 Stavanger, Norway; School of Civil and Environmental Engineering, Yonsei University, Seoul 03722, Republic of Korea. Electronic address: .
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Źródło :
Bioresource technology [Bioresour Technol] 2021 Mar; Vol. 324, pp. 124596. Date of Electronic Publication: 2020 Dec 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Directed Molecular Evolution*
Industry*
Catalysis ; Enzymes/genetics ; Enzymes/metabolism ; Molecular Biology ; Protein Engineering ; Substrate Specificity
Czasopismo naukowe
Tytuł :
[Heterologous expression of a novel β-glucosidase BglD2 and its application in polydatin-hydrolyzing].
Autorzy :
He C; School of Life Sciences, Anhui University, Hefei 230601, Anhui, China.
Wu Y; School of Life Sciences, Anhui University, Hefei 230601, Anhui, China.
Meng C; School of Life Sciences, Anhui University, Hefei 230601, Anhui, China.
Xiao Y; School of Life Sciences, Anhui University, Hefei 230601, Anhui, China.
Fang Z; School of Life Sciences, Anhui University, Hefei 230601, Anhui, China.
Fang W; School of Life Sciences, Anhui University, Hefei 230601, Anhui, China.
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Źródło :
Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Sheng Wu Gong Cheng Xue Bao] 2021 Feb 25; Vol. 37 (2), pp. 580-592.
Typ publikacji :
Journal Article
MeSH Terms :
Stilbenes*/pharmacology
beta-Glucosidase*/genetics
Enzyme Stability ; Glucose ; Glucosides/pharmacology ; Hydrogen-Ion Concentration ; Substrate Specificity ; Temperature ; Xylose
Czasopismo naukowe
Tytuł :
RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination.
Autorzy :
Kiss L; MRC Laboratory of Molecular Biology, Cambridge, UK. .
Clift D; MRC Laboratory of Molecular Biology, Cambridge, UK.
Renner N; MRC Laboratory of Molecular Biology, Cambridge, UK.
Neuhaus D; MRC Laboratory of Molecular Biology, Cambridge, UK.
James LC; MRC Laboratory of Molecular Biology, Cambridge, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 22; Vol. 12 (1), pp. 1220. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biocatalysis*
RING Finger Domains*
Ubiquitination*
Animals ; Female ; Male ; Mice ; Models, Molecular ; NIH 3T3 Cells ; Proteolysis ; Ribonucleoproteins/chemistry ; Substrate Specificity ; Ubiquitin/chemistry ; Ubiquitin/metabolism
Czasopismo naukowe
Tytuł :
Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism.
Autorzy :
Kumar G; Department of Structural Biology, Memphis, TN 38105, USA.
Cuypers M; Department of Structural Biology, Memphis, TN 38105, USA.
Webby RR; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Webb TR; Wildflower Biopharma, Inc., 8650 Genesee Ave. STE 214, San Diego, CA 92122, USA.; Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
White SW; Department of Structural Biology, Memphis, TN 38105, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Feb 22; Vol. 49 (3), pp. 1609-1618.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Endoribonucleases/*chemistry
Influenza A Virus, H1N1 Subtype/*enzymology
Viral Proteins/*chemistry
Antiviral Agents/chemistry ; DNA/chemistry ; Dibenzothiepins/chemistry ; Endoribonucleases/metabolism ; Models, Molecular ; Morpholines/chemistry ; Pyridones/chemistry ; RNA/chemistry ; Substrate Specificity ; Triazines/chemistry ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
Active-site loop variations adjust activity and selectivity of the cumene dioxygenase.
Autorzy :
Heinemann PM; Institute of Biochemistry and Technical Biochemistry, Department of Technical Biochemistry, University of Stuttgart, Stuttgart, Germany.
Armbruster D; Institute of Biochemistry and Technical Biochemistry, Department of Technical Biochemistry, University of Stuttgart, Stuttgart, Germany.
Hauer B; Institute of Biochemistry and Technical Biochemistry, Department of Technical Biochemistry, University of Stuttgart, Stuttgart, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 17; Vol. 12 (1), pp. 1095. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Catalytic Domain*
Bacterial Proteins/*metabolism
Dioxygenases/*metabolism
Protein Engineering/*methods
Pseudomonas fluorescens/*enzymology
Amino Acid Sequence ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Binding Sites ; Biocatalysis ; Dioxygenases/chemistry ; Dioxygenases/genetics ; Models, Molecular ; Protein Conformation ; Pseudomonas fluorescens/genetics ; Sequence Homology, Amino Acid ; Substrate Specificity
Czasopismo naukowe
Tytuł :
The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.
Autorzy :
Davydova E; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316, Oslo, Norway.
Shimazu T; Cellular Memory Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan.
Schuhmacher MK; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany.
Jakobsson ME; Proteomics Program, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research (NNF-CPR), University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.; Department of Immunotechnology, Lund University, Medicon Village, 22100, Lund, Sweden.
Willemen HLDM; Center for Translational Immunology (CTI), University Medical Center Utrecht, Utrecht University, 3584, Utrecht, EA, The Netherlands.
Liu T; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Moen A; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316, Oslo, Norway.
Ho AYY; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316, Oslo, Norway.
Małecki J; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316, Oslo, Norway.
Schroer L; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316, Oslo, Norway.
Pinto R; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316, Oslo, Norway.; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
Suzuki T; Biomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Grønsberg IA; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316, Oslo, Norway.
Sohtome Y; Synthetic Organic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan.; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Akakabe M; Synthetic Organic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan.
Weirich S; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany.
Kikuchi M; Laboratory for Epigenetics Drug Discovery, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan.
Olsen JV; Proteomics Program, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research (NNF-CPR), University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.
Dohmae N; Biomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Umehara T; Laboratory for Epigenetics Drug Discovery, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan.
Sodeoka M; Synthetic Organic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan.; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Siino V; Department of Immunotechnology, Lund University, Medicon Village, 22100, Lund, Sweden.
McDonough MA; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Eijkelkamp N; Center for Translational Immunology (CTI), University Medical Center Utrecht, Utrecht University, 3584, Utrecht, EA, The Netherlands.
Schofield CJ; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Jeltsch A; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany. .
Shinkai Y; Cellular Memory Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan. .
Falnes PØ; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316, Oslo, Norway. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 09; Vol. 12 (1), pp. 891. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Methylhistidines/*metabolism
Methyltransferases/*metabolism
Proteome/*metabolism
Amino Acid Motifs ; Animals ; Cells, Cultured ; Histidine/metabolism ; Humans ; Mammals/classification ; Mammals/genetics ; Mammals/metabolism ; Methylation ; Methyltransferases/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria/metabolism ; Mutation ; Protein Processing, Post-Translational ; Proteome/chemistry ; Substrate Specificity ; Zinc/metabolism
Czasopismo naukowe
Tytuł :
Study of Specific Receptor Binding Mode Suggests a Possible Enzymatic Disinfectant for SARS-CoV-2.
Autorzy :
Cao Y; Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
Ge J; Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.; Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China.; Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen 518038, China.
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Źródło :
Langmuir : the ACS journal of surfaces and colloids [Langmuir] 2021 Feb 09; Vol. 37 (5), pp. 1707-1713. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2/*metabolism
Peptide Hydrolases/*metabolism
SARS-CoV-2/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Amino Acid Sequence ; Angiotensin-Converting Enzyme 2/chemistry ; Molecular Dynamics Simulation ; Protein Binding ; Protein Domains ; SARS-CoV-2/physiology ; Substrate Specificity ; Thermodynamics
Czasopismo naukowe
Tytuł :
Development of a thin-layer chromatography bioautographic assay for neuraminidase inhibitors hyphenated with electrostatic field induced spray ionisation-mass spectrometry for identification of active Isatis indigotica root compounds.
Autorzy :
Zang Y; Department of Natural Medicine, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
Miao Y; Key Laboratory of Standardization of Chinese Medicines of Ministry of Education, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
Wu T; Key Laboratory of Standardization of Chinese Medicines of Ministry of Education, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China. Electronic address: .
Cheng Z; Department of Natural Medicine, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China. Electronic address: .
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2021 Feb 08; Vol. 1638, pp. 461597. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :
Journal Article
MeSH Terms :
Static Electricity*
Chromatography, Thin Layer/*methods
Enzyme Inhibitors/*analysis
Enzyme Inhibitors/*pharmacology
Isatis/*chemistry
Mass Spectrometry/*methods
Neuraminidase/*antagonists & inhibitors
Plant Roots/*chemistry
Analysis of Variance ; Biological Assay ; Calcium Chloride/pharmacology ; Chemical Fractionation ; Enzyme Inhibitors/chemistry ; Hydrogen-Ion Concentration ; Limit of Detection ; Plant Extracts/chemistry ; Spectrophotometry, Ultraviolet ; Substrate Specificity/drug effects ; Time Factors
Czasopismo naukowe
Tytuł :
Structural basis for the biosynthesis of lovastatin.
Autorzy :
Wang J; State Key Laboratory of Microbial Metabolism and School of Life Science & Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Liang J; State Key Laboratory of Microbial Metabolism and School of Life Science & Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Chen L; State Key Laboratory of Microbial Metabolism and School of Life Science & Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Zhang W; State Key Laboratory of Microbial Metabolism and School of Life Science & Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Kong L; National Facility for Protein Science in Shanghai, Shanghai, China.
Peng C; National Facility for Protein Science in Shanghai, Shanghai, China.
Su C; National Facility for Protein Science in Shanghai, Shanghai, China.
Tang Y; Department of Chemical and Biomolecular Engineering and Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA.
Deng Z; State Key Laboratory of Microbial Metabolism and School of Life Science & Biotechnology, Shanghai Jiao Tong University, Shanghai, China. .
Wang Z; State Key Laboratory of Microbial Metabolism and School of Life Science & Biotechnology, Shanghai Jiao Tong University, Shanghai, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 08; Vol. 12 (1), pp. 867. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lovastatin/*biosynthesis
Lovastatin/*chemistry
Biocatalysis ; Models, Molecular ; Naphthalenes/metabolism ; Oxidoreductases Acting on CH-CH Group Donors/chemistry ; Oxidoreductases Acting on CH-CH Group Donors/metabolism ; Polyketide Synthases/chemistry ; Polyketide Synthases/metabolism ; Polyketide Synthases/ultrastructure ; Protein Domains ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Mechanism of the small ATP-independent chaperone Spy is substrate specific.
Autorzy :
Mitra R; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Gadkari VV; Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.
Meinen BA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
van Mierlo CPM; Laboratory of Biochemistry, Wageningen University, Wageningen, The Netherlands.
Ruotolo BT; Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.
Bardwell JCA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA. .; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 08; Vol. 12 (1), pp. 851. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Triphosphate/*metabolism
Molecular Chaperones/*metabolism
Periplasmic Proteins/*metabolism
Anabaena/metabolism ; Apoproteins/chemistry ; Apoproteins/metabolism ; Azotobacter/metabolism ; Escherichia coli/metabolism ; Flavodoxin/chemistry ; Flavodoxin/metabolism ; Kinetics ; Magnetic Resonance Spectroscopy ; Molecular Conformation ; Mutant Proteins/metabolism ; Periplasmic Proteins/chemistry ; Protein Binding ; Protein Folding ; Substrate Specificity
Czasopismo naukowe
Tytuł :
The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans.
Autorzy :
Chaves DA; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA; Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Dai H; Department of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, CA, USA.
Li L; Department of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, CA, USA.
Moresco JJ; Center for Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX, USA.
Oh ME; Department of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, CA, USA.
Conte D Jr; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
Yates JR 3rd; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA, USA.
Mello CC; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
Gu W; Department of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, CA, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Feb 04; Vol. 81 (3), pp. 546-557.e5. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Processing, Post-Transcriptional*
Caenorhabditis elegans/*enzymology
Caenorhabditis elegans Proteins/*metabolism
Phosphoric Monoester Hydrolases/*metabolism
RNA/*metabolism
Animals ; Animals, Genetically Modified ; Caenorhabditis elegans/embryology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/genetics ; Gene Expression Regulation, Developmental ; Phosphoric Monoester Hydrolases/genetics ; Phosphorylation ; RNA/genetics ; RNA Caps ; RNA-Dependent RNA Polymerase/genetics ; RNA-Dependent RNA Polymerase/metabolism ; Ribonuclease III/genetics ; Ribonuclease III/metabolism ; Spermatogenesis ; Substrate Specificity
Czasopismo naukowe
Tytuł :
The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases.
Autorzy :
Mäkinen JJ; Department of Biochemistry, University of Turku, Turku, Finland.
Shin Y; Department of Biochemistry and Molecular Biology, The Center for RNA Molecular Biology, The Pennsylvania State University, University Park, PA, USA.
Vieras E; Department of Biochemistry, University of Turku, Turku, Finland.
Virta P; Department of Chemistry, University of Turku, Turku, Finland.
Metsä-Ketelä M; Department of Biochemistry, University of Turku, Turku, Finland.
Murakami KS; Department of Biochemistry and Molecular Biology, The Center for RNA Molecular Biology, The Pennsylvania State University, University Park, PA, USA. .
Belogurov GA; Department of Biochemistry, University of Turku, Turku, Finland. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 04; Vol. 12 (1), pp. 796. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*metabolism
DNA-Directed RNA Polymerases/*metabolism
Deoxyribonucleotides/*metabolism
Deoxyribose/*metabolism
Arginine/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/isolation & purification ; Bacterial Proteins/ultrastructure ; Crystallography, X-Ray ; DNA-Directed RNA Polymerases/genetics ; DNA-Directed RNA Polymerases/isolation & purification ; DNA-Directed RNA Polymerases/ultrastructure ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Kinetics ; Molecular Docking Simulation ; Promoter Regions, Genetic ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Recombinant Proteins/ultrastructure ; Substrate Specificity ; Thermus thermophilus/enzymology ; Thermus thermophilus/genetics
Czasopismo naukowe
Tytuł :
The ubiquitin ligase RFWD3 is required for translesion DNA synthesis.
Autorzy :
Gallina I; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Hendriks IA; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Hoffmann S; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Larsen NB; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Johansen J; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Colding-Christensen CS; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Schubert L; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Sellés-Baiget S; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Fábián Z; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Kühbacher U; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Gao AO; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Räschle M; Department of Molecular Biotechnology and Systems Biology, Technical University of Kaiserslautern, 67653 Kaiserslautern, Germany.
Rasmussen S; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Nielsen ML; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Mailand N; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Duxin JP; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Feb 04; Vol. 81 (3), pp. 442-458.e9. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Single-Stranded*
DNA Repair*
DNA Replication*
Chromatin/*metabolism
Proliferating Cell Nuclear Antigen/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Animals ; Cell Line, Tumor ; Chromatin/genetics ; DNA-Directed DNA Polymerase/metabolism ; Female ; Humans ; Proliferating Cell Nuclear Antigen/genetics ; Substrate Specificity ; Ubiquitin-Protein Ligases/genetics ; Ubiquitination ; Xenopus laevis
Czasopismo naukowe

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