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Wyświetlanie 1-15 z 15
Tytuł :
Grb2 binding induces phosphorylation-independent activation of Shp2.
Autorzy :
Lin CC; School of Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK. .
Wieteska L; School of Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.
Suen KM; School of Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, UK.
Kalverda AP; School of Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.
Ahmed Z; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ladbury JE; School of Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK. .; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, India. .
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Źródło :
Communications biology [Commun Biol] 2021 Apr 01; Vol. 4 (1), pp. 437. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
GRB2 Adaptor Protein/*genetics
Protein Tyrosine Phosphatase, Non-Receptor Type 11/*genetics
Enzyme Activation ; GRB2 Adaptor Protein/metabolism ; Phosphorylation ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/metabolism
Czasopismo naukowe
Tytuł :
DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans.
Autorzy :
Suen KM; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.; Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK.
Braukmann F; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.; Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK.
Butler R; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.
Bensaddek D; Laboratory for Quantitative Proteomics, Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.; Bioscience Core labs, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Saudi Arabia.
Akay A; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.; Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK.; School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK.
Lin CC; School of Molecular and Cellular Biology, University of Leeds, LC Miall Building, Leeds, LS2 9JT, UK.
Milonaitytė D; School of Molecular and Cellular Biology, University of Leeds, LC Miall Building, Leeds, LS2 9JT, UK.
Doshi N; University of Cambridge, School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0SP, UK.
Sapetschnig A; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK.
Lamond A; Laboratory for Quantitative Proteomics, Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.
Ladbury JE; School of Molecular and Cellular Biology, University of Leeds, LC Miall Building, Leeds, LS2 9JT, UK.
Miska EA; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK. .; Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK. .; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 25; Vol. 11 (1), pp. 4242. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Silencing*
Argonaute Proteins/*metabolism
Caenorhabditis elegans/*metabolism
Caenorhabditis elegans Proteins/*metabolism
RNA, Small Interfering/*metabolism
Animals ; Argonaute Proteins/genetics ; Binding Sites ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/chemistry ; Caenorhabditis elegans Proteins/genetics ; Cytoplasmic Granules/metabolism ; Germ Cells/metabolism ; Mutation ; Protein Binding ; Proteomics ; RNA Interference ; RNA, Double-Stranded/metabolism ; RNA, Small Interfering/genetics
Czasopismo naukowe
Tytuł :
Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling.
Autorzy :
Lin CC; School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK.
Suen KM; School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.
Stainthorp A; School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK.
Wieteska L; School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK.
Biggs GS; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EQ, UK.
Leitão A; Medicinal Chemistry Group (NEQUIMED), São Carlos Institute of Chemistry, University of São Paulo (IQSC-USP), 13566-590, São Carlos, SP, Brazil.
Montanari CA; Medicinal Chemistry Group (NEQUIMED), São Carlos Institute of Chemistry, University of São Paulo (IQSC-USP), 13566-590, São Carlos, SP, Brazil.
Ladbury JE; School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK; Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Aug 10; Vol. 457, pp. 86-97. Date of Electronic Publication: 2019 May 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Repositioning*
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Antineoplastic Agents/*pharmacology
Indomethacin/*pharmacology
MAP Kinase Signaling System/*drug effects
Neoplasms/*drug therapy
Shc Signaling Adaptor Proteins/*antagonists & inhibitors
Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/metabolism ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Cell Movement/drug effects ; ErbB Receptors/chemistry ; ErbB Receptors/metabolism ; HeLa Cells ; Humans ; Indomethacin/chemistry ; Indomethacin/metabolism ; MCF-7 Cells ; Molecular Docking Simulation ; Neoplasm Invasiveness ; Neoplasms/enzymology ; Neoplasms/pathology ; Phosphorylation ; Protein Binding ; Protein Conformation ; Protein Interaction Domains and Motifs ; Shc Signaling Adaptor Proteins/chemistry ; Shc Signaling Adaptor Proteins/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells.
Autorzy :
Suen KM; Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Unit 1954, 1515 Holcombe Blvd, Houston, TX 77030, USA; Graduate School of Biological Sciences, The University of Texas MD Anderson Cancer Center, Unit 1954, 1515 Holcombe Blvd, Houston, TX 77030, USA.
Lin CC; School of Molecular and Cellular Biology, University of Leeds, LC Miall Building, Leeds, LS2 9JT, UK.
Seiler C; School of Molecular and Cellular Biology, University of Leeds, LC Miall Building, Leeds, LS2 9JT, UK.
George R; Structural Biology STP, The Francis Crick Institute, Lincolns Inn Fields Laboratory, 44 Lincolns Inn Fields, Holborn, London, WC2A 3LY, UK.
Poncet-Montange G; Orthogon Therapeutics, 960 Turnpike Street, Unit 10, Canton, MA 02021, USA.
Biter AB; Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development, 1102 Bates Avenue, Houston, TX 77030, USA.
Ahmed Z; Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Unit 1954, 1515 Holcombe Blvd, Houston, TX 77030, USA.
Arold ST; Division of Biological and Environmental Sciences and Engineering, CBRC, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.
Ladbury JE; School of Molecular and Cellular Biology, University of Leeds, LC Miall Building, Leeds, LS2 9JT, UK. Electronic address: .
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Źródło :
The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2018 Jan; Vol. 94, pp. 89-97. Date of Electronic Publication: 2017 Dec 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
MAP Kinase Signaling System*
Models, Biological*
Protein Processing, Post-Translational*
Receptor Cross-Talk*
Proto-Oncogene Proteins c-akt/*metabolism
Src Homology 2 Domain-Containing, Transforming Protein 1/*metabolism
Triple Negative Breast Neoplasms/*metabolism
14-3-3 Proteins/metabolism ; Animals ; Cell Line, Tumor ; Female ; HEK293 Cells ; Humans ; Ligands ; Mutation ; NIMA-Interacting Peptidylprolyl Isomerase/metabolism ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Phosphorylation ; Rats ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/metabolism ; Src Homology 2 Domain-Containing, Transforming Protein 1/chemistry ; Src Homology 2 Domain-Containing, Transforming Protein 1/genetics ; Threonine/metabolism ; Triple Negative Breast Neoplasms/enzymology ; Up-Regulation
Czasopismo naukowe
Tytuł :
The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription.
Autorzy :
Akay A; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.
Di Domenico T; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.
Suen KM; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.
Nabih A; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Parada GE; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.
Larance M; Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Medhi R; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.
Berkyurek AC; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.
Zhang X; Department of Statistics, University of Georgia, Athens, GA 30602, USA.
Wedeles CJ; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Rudolph KLM; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.
Engelhardt J; Bioinformatics Group, Department of Computer Science, Interdisciplinary Center for Bioinformatics, University of Leipzig, Haertelstraße 16-18, Leipzig 04107, Germany.
Hemberg M; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.
Ma P; Department of Statistics, University of Georgia, Athens, GA 30602, USA.
Lamond AI; Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Claycomb JM; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Miska EA; Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK. Electronic address: .
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Źródło :
Developmental cell [Dev Cell] 2017 Aug 07; Vol. 42 (3), pp. 241-255.e6.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms :
RNA Interference*
Argonaute Proteins/*genetics
Caenorhabditis elegans/*genetics
Caenorhabditis elegans Proteins/*genetics
Nuclear Proteins/*genetics
Animals ; Argonaute Proteins/metabolism ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/metabolism ; DNA Transposable Elements ; Introns ; Nuclear Proteins/metabolism ; Protein Binding
Czasopismo naukowe
Tytuł :
Grb2 monomer-dimer equilibrium determines normal versus oncogenic function.
Autorzy :
Ahmed Z; 1] Department of Biochemistry and Molecular Biology, University of Texas, M.D. Anderson Cancer Center, Unit 1000, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [2] Center for Biomolecular Structure and Function, University of Texas, M.D. Anderson Cancer Center, Unit 1000, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.
Timsah Z; 1] Department of Biochemistry and Molecular Biology, University of Texas, M.D. Anderson Cancer Center, Unit 1000, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [2] School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.
Suen KM; 1] Department of Biochemistry and Molecular Biology, University of Texas, M.D. Anderson Cancer Center, Unit 1000, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [2] School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.
Cook NP; Department of Chemistry, Rice University, Houston, Texas 77005, USA.
Lee GR 4th; Center for Biomolecular Structure and Function, University of Texas, M.D. Anderson Cancer Center, Unit 1000, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.
Lin CC; 1] Department of Biochemistry and Molecular Biology, University of Texas, M.D. Anderson Cancer Center, Unit 1000, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [2] School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.
Gagea M; Department of Veterinary Medicine and Surgery, University of Texas, M.D. Anderson Cancer Center, Unit 63, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.
Marti AA; Department of Chemistry, Rice University, Houston, Texas 77005, USA.
Ladbury JE; 1] Department of Biochemistry and Molecular Biology, University of Texas, M.D. Anderson Cancer Center, Unit 1000, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [2] Center for Biomolecular Structure and Function, University of Texas, M.D. Anderson Cancer Center, Unit 1000, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [3] School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.
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Źródło :
Nature communications [Nat Commun] 2015 Jun 24; Vol. 6, pp. 7354. Date of Electronic Publication: 2015 Jun 24.
Typ publikacji :
Journal Article
MeSH Terms :
MAP Kinase Signaling System*
Protein Multimerization*
Breast Neoplasms/*metabolism
Colonic Neoplasms/*metabolism
GRB2 Adaptor Protein/*metabolism
Prostatic Neoplasms/*metabolism
Female ; GRB2 Adaptor Protein/chemistry ; HEK293 Cells ; Humans ; Male ; Phosphorylation ; Signal Transduction ; Son of Sevenless Proteins/metabolism ; Tissue Array Analysis ; Tyrosine/metabolism ; src Homology Domains
Czasopismo naukowe
Tytuł :
A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans.
Autorzy :
Drake M; Department of Genetics, UT MD Anderson Cancer Center, Houston, TX 77030, USA.
Furuta T; Department of Genetics, UT MD Anderson Cancer Center, Houston, TX 77030, USA.
Suen KM; Department of Biochemistry and Molecular Biology, UT MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Gonzalez G; Department of Genetics, UT MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Liu B; Center for Genetics and Genomics, UT MD Anderson Cancer Center, Houston, TX 77030, USA.
Kalia A; Graduate Program in Diagnostic Genetics, School of Health Professions, UT MD Anderson Cancer Center, Houston, TX 77030, USA.
Ladbury JE; Department of Biochemistry and Molecular Biology, UT MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Fire AZ; Department of Pathology and Genetics, Stanford University, Stanford, CA 94305, USA.
Skeath JB; Department of Genetics, Washington University School of Medicine, Scott Avenue, St. Louis, MO 63110, USA.
Arur S; Department of Genetics, UT MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, Houston, TX 77030, USA; Center for Genetics and Genomics, UT MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: .
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Źródło :
Developmental cell [Dev Cell] 2014 Dec 08; Vol. 31 (5), pp. 614-28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Caenorhabditis elegans/*enzymology
MAP Kinase Signaling System/*physiology
Oocytes/*metabolism
RNA, Double-Stranded/*metabolism
Ribonuclease III/*metabolism
Animals ; Base Sequence/physiology ; Caenorhabditis elegans/embryology ; Mice ; Oogenesis/physiology ; Phosphorylation
Czasopismo naukowe
Tytuł :
Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli.
Autorzy :
Suen KM; Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Lin CC
George R
Melo FA
Biggs ER
Ahmed Z
Drake MN
Arur S
Arold ST
Ladbury JE
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2013 May; Vol. 20 (5), pp. 620-7. Date of Electronic Publication: 2013 Apr 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Interaction Mapping*
Signal Transduction*
Mitogen-Activated Protein Kinase 1/*metabolism
Shc Signaling Adaptor Proteins/*metabolism
Binding Sites ; Cell Line ; Humans ; Protein Binding ; Src Homology 2 Domain-Containing, Transforming Protein 1
Czasopismo naukowe
Tytuł :
Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity.
Autorzy :
Ahmed Z; Department of Biochemistry and Molecular Biology and Center for Biomolecular Structure and Function, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. />Lin CC
Suen KM
Melo FA
Levitt JA
Suhling K
Ladbury JE
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Źródło :
The Journal of cell biology [J Cell Biol] 2013 Feb 18; Vol. 200 (4), pp. 493-504.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
GRB2 Adaptor Protein/*physiology
Protein Tyrosine Phosphatase, Non-Receptor Type 11/*physiology
Receptor, Fibroblast Growth Factor, Type 2/*metabolism
GRB2 Adaptor Protein/genetics ; GRB2 Adaptor Protein/metabolism ; Gene Knockdown Techniques ; HEK293 Cells ; Humans ; MAP Kinase Signaling System ; Phosphorylation ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/metabolism
Czasopismo naukowe
Tytuł :
Inhibition of basal FGF receptor signaling by dimeric Grb2.
Autorzy :
Lin CC; Department of Biochemistry and Molecular Biology and Center for Biomolecular Structure and Function, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Melo FA
Ghosh R
Suen KM
Stagg LJ
Kirkpatrick J
Arold ST
Ahmed Z
Ladbury JE
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Źródło :
Cell [Cell] 2012 Jun 22; Vol. 149 (7), pp. 1514-24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
GRB2 Adaptor Protein/*metabolism
Receptor, Fibroblast Growth Factor, Type 2/*metabolism
Dimerization ; HEK293 Cells ; Humans ; Models, Molecular ; Phosphorylation ; Receptor, Fibroblast Growth Factor, Type 2/chemistry
Czasopismo naukowe
Tytuł :
Enhancement of the immunogenicity of an alphavirus replicon-based DNA vaccine against classical swine fever by electroporation and coinjection with a plasmid expressing porcine interleukin 2.
Autorzy :
Tian DY; Division of Swine Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China.
Sun Y
Wai SF
Lee FK
Meng QL
Suen KM
Wang N
Han W
Li S
Li YF
Li D
Ling LJ
Liao YJ
Qiu HJ
Pokaż więcej
Źródło :
Vaccine [Vaccine] 2012 May 21; Vol. 30 (24), pp. 3587-94. Date of Electronic Publication: 2012 Mar 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adjuvants, Immunologic/*administration & dosage
Alphavirus/*genetics
Classical Swine Fever/*prevention & control
Electroporation/*methods
Interleukin-2/*administration & dosage
Vaccines, DNA/*administration & dosage
Vaccines, DNA/*immunology
Adjuvants, Immunologic/genetics ; Animals ; Antibodies, Viral/blood ; Cell Proliferation ; Classical Swine Fever/immunology ; Genetic Vectors ; Interferon-gamma/metabolism ; Interleukin-2/genetics ; Interleukin-4/metabolism ; Lymphocytes/immunology ; Plasmids/administration & dosage ; Swine ; Vaccines, DNA/genetics ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/genetics ; Vaccines, Synthetic/immunology
Czasopismo naukowe
Tytuł :
Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function.
Autorzy :
Ahmed Z; Department of Structural & Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK.
George R
Lin CC
Suen KM
Levitt JA
Suhling K
Ladbury JE
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Źródło :
Cellular signalling [Cell Signal] 2010 Jan; Vol. 22 (1), pp. 23-33. Date of Electronic Publication: 2009 Sep 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
src Homology Domains*
GRB2 Adaptor Protein/*metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 11/*metabolism
Receptor, Fibroblast Growth Factor, Type 2/*metabolism
Amino Acid Sequence ; Animals ; Calorimetry ; Cell Line ; GRB2 Adaptor Protein/chemistry ; Humans ; Mice ; Molecular Sequence Data ; Phosphorylation ; Protein Binding ; Receptor, Fibroblast Growth Factor, Type 2/chemistry ; Receptor, Fibroblast Growth Factor, Type 2/genetics ; Sequence Alignment
Czasopismo naukowe
Tytuł :
A complex of Shc and Ran-GTPase localises to the cell nucleus.
Autorzy :
George R; Department of Biochemistry and Molecular Biology, University College London, UK.
Chan HL
Ahmed Z
Suen KM
Stevens CN
Levitt JA
Suhling K
Timms J
Ladbury JE
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2009 Feb; Vol. 66 (4), pp. 711-20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Nucleus/*metabolism
Multiprotein Complexes/*metabolism
Protein Isoforms/*metabolism
Shc Signaling Adaptor Proteins/*metabolism
ran GTP-Binding Protein/*metabolism
Animals ; Blotting, Far-Western ; Dogs ; GRB2 Adaptor Protein/genetics ; GRB2 Adaptor Protein/metabolism ; Humans ; Jurkat Cells ; Nucleocytoplasmic Transport Proteins/genetics ; Nucleocytoplasmic Transport Proteins/metabolism ; Protein Isoforms/genetics ; Shc Signaling Adaptor Proteins/genetics ; Signal Transduction/physiology ; ran GTP-Binding Protein/genetics
Czasopismo naukowe
Tytuł :
Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2).
Autorzy :
Schüller AC; Department of Biochemistry and Molecular Biology, Darwin Building, Gower Street, London WC1E6BT, UK.
Ahmed Z
Levitt JA
Suen KM
Suhling K
Ladbury JE
Pokaż więcej
Źródło :
The Biochemical journal [Biochem J] 2008 Dec 01; Vol. 416 (2), pp. 189-99.
Typ publikacji :
Journal Article
MeSH Terms :
Receptor Protein-Tyrosine Kinases/*metabolism
Receptor, Fibroblast Growth Factor, Type 2/*physiology
Shc Signaling Adaptor Proteins/*physiology
Signal Transduction/*physiology
Animals ; Cell Line ; Cell Membrane/physiology ; Cloning, Molecular ; DNA, Complementary/genetics ; Genes, Reporter ; Humans ; Intracellular Membranes/physiology ; Kidney/embryology ; PC12 Cells ; Phosphorylation ; Polymerase Chain Reaction ; Rats ; Receptor, Fibroblast Growth Factor, Type 2/genetics ; Transfection
Czasopismo naukowe
    Wyświetlanie 1-15 z 15

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