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Wyszukujesz frazę ""Sulfonamides"" wg kryterium: Temat


Tytuł:
Synthesis, anti-inflammatory, cytotoxic, and COX-1/2 inhibitory activities of cyclic imides bearing 3-benzenesulfonamide, oxime, and β-phenylalanine scaffolds: a molecular docking study.
Autorzy:
Abdel-Aziz AA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
El-Azab AS; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
AlSaif NA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Alanazi MM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
El-Gendy MA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Obaidullah AJ; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Alkahtani HM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Almehizia AA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Al-Suwaidan IA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 610-621.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Antineoplastic Agents/*pharmacology
Cyclooxygenase Inhibitors/*pharmacology
Imides/*pharmacology
Oximes/*pharmacology
Phenylalanine/*pharmacology
Sulfonamides/*pharmacology
Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclooxygenase 1/metabolism ; Cyclooxygenase 2/metabolism ; Cyclooxygenase Inhibitors/chemical synthesis ; Cyclooxygenase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Edema/drug therapy ; Humans ; Imides/chemistry ; Molecular Docking Simulation ; Molecular Structure ; Oximes/chemistry ; Phenylalanine/chemistry ; Rats ; Structure-Activity Relationship ; Sulfonamides/chemistry ; Benzenesulfonamides
Czasopismo naukowe
Tytuł:
Development of in vitro - in vivo correlations for newly optimized Nimesulide formulations.
Autorzy:
Hanif M; Department of Pharmaceutics, Faculty of Pharmacy, Bahaudin Zakaria University Multan, Punjab, Pakistan.
Shoaib MH; Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Sindh, Karachi, Pakistan.
Yousuf RI; Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Sindh, Karachi, Pakistan.
Zafar F; Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Sindh, Karachi, Pakistan.
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Źródło:
PloS one [PLoS One] 2018 Aug 31; Vol. 13 (8), pp. e0203123. Date of Electronic Publication: 2018 Aug 31 (Print Publication: 2018).
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Cyclooxygenase Inhibitors/*administration & dosage
Cyclooxygenase Inhibitors/*pharmacokinetics
Sulfonamides/*administration & dosage
Sulfonamides/*pharmacokinetics
Adolescent ; Adult ; Cross-Over Studies ; Delayed-Action Preparations ; Drug Liberation ; Humans ; Male ; Tablets ; Therapeutic Equivalency ; Young Adult
Czasopismo naukowe
Tytuł:
Synthesis and cycloxygenase inhibitory properties of new naphthalene-methylsulfonamido, naphthalene-methylsulfonyl and tetrahydronaphthalen-methylsulfonamido compounds.
Autorzy:
Nencetti S; Dipartimento di Farmacia, Università Pisa Via Bonanno , Pisa , Italy and.
Ciccone L
Rossello A
Nuti E
Milanese C
Orlandini E
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2015 Jun; Vol. 30 (3), pp. 406-12. Date of Electronic Publication: 2014 Aug 04.
Typ publikacji:
Journal Article
MeSH Terms:
Cyclooxygenase 1/*metabolism
Cyclooxygenase 2/*metabolism
Cyclooxygenase Inhibitors/*pharmacology
Naphthalenes/*pharmacology
Sulfonamides/*pharmacology
Animals ; Cyclooxygenase Inhibitors/chemical synthesis ; Cyclooxygenase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Mice ; Molecular Structure ; Naphthalenes/chemical synthesis ; Naphthalenes/chemistry ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry
Czasopismo naukowe
Tytuł:
The COX-2-Selective Antagonist (NS-398) Inhibits Choroidal Neovascularization and Subretinal Fibrosis.
Autorzy:
Zhang R; Department of Ophthalmology, The first affiliated hospital of China Medical University, Shenyang City, liaoning Province, China.
Liu Z; Department of Ophthalmology, The first affiliated hospital of China Medical University, Shenyang City, liaoning Province, China.
Zhang H; Department of Ophthalmology, The first affiliated hospital of China Medical University, Shenyang City, liaoning Province, China.
Zhang Y; Department of Ophthalmology, The first affiliated hospital of China Medical University, Shenyang City, liaoning Province, China.
Lin D; Department of Ophthalmology, The first affiliated hospital of China Medical University, Shenyang City, liaoning Province, China.
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Źródło:
PloS one [PLoS One] 2016 Jan 13; Vol. 11 (1), pp. e0146808. Date of Electronic Publication: 2016 Jan 13 (Print Publication: 2016).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Choroidal Neovascularization/*drug therapy
Cyclooxygenase Inhibitors/*therapeutic use
Nitrobenzenes/*therapeutic use
Retina/*pathology
Sulfonamides/*therapeutic use
Animals ; Choroid/drug effects ; Choroid/metabolism ; Choroid/pathology ; Choroidal Neovascularization/pathology ; Cyclooxygenase Inhibitors/pharmacology ; Disease Models, Animal ; Fibrosis ; Macrophages/drug effects ; Macrophages/pathology ; Mice, Inbred C57BL ; Nitrobenzenes/pharmacology ; Retina/drug effects ; Retinal Pigment Epithelium/drug effects ; Retinal Pigment Epithelium/metabolism ; Retinal Pigment Epithelium/pathology ; Sulfonamides/pharmacology ; Transforming Growth Factor beta2/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł:
Quantification of nimesulide in human plasma by high-performance liquid chromatography with ultraviolet detector (HPLC-UV): application to pharmacokinetic studies in 28 healthy Korean subjects.
Autorzy:
Kim MS; Department of Dermatology, Eulji Medical Center, College of Medicine, Seoul 139-872, South Korea.
Park YS
Kim SH
Kim SY
Lee MH
Kim YH
Kim DW
Yang SC
Kang JS
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Źródło:
Journal of chromatographic science [J Chromatogr Sci] 2012 May; Vol. 50 (5), pp. 396-400. Date of Electronic Publication: 2012 Mar 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms:
Anti-Inflammatory Agents, Non-Steroidal/*blood
Chromatography, High Pressure Liquid/*methods
Cyclooxygenase Inhibitors/*blood
Sulfonamides/*blood
Administration, Oral ; Adult ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Area Under Curve ; Asian People ; Chromatography, High Pressure Liquid/economics ; Cyclooxygenase Inhibitors/administration & dosage ; Humans ; Male ; Sensitivity and Specificity ; Sulfonamides/administration & dosage ; Young Adult
Czasopismo naukowe
Tytuł:
A randomized, multicentre, double-blind, parallel-group study to assess the adverse event-related discontinuation rate with celecoxib and diclofenac in elderly patients with osteoarthritis.
Autorzy:
Dahlberg LE; Department of Orthopaedics, Lund University, Malmö University Hospital, Malmö, Sweden. />Holme I
Høye K
Ringertz B
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Źródło:
Scandinavian journal of rheumatology [Scand J Rheumatol] 2009 Mar-Apr; Vol. 38 (2), pp. 133-43.
Typ publikacji:
Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Cyclooxygenase Inhibitors/*adverse effects
Diclofenac/*adverse effects
Osteoarthritis, Hip/*drug therapy
Osteoarthritis, Knee/*drug therapy
Pyrazoles/*adverse effects
Sulfonamides/*adverse effects
Aged ; Celecoxib ; Cyclooxygenase Inhibitors/economics ; Diclofenac/economics ; Double-Blind Method ; Drug Costs ; Female ; Health Status ; Humans ; Male ; Osteoarthritis, Hip/mortality ; Osteoarthritis, Hip/physiopathology ; Osteoarthritis, Knee/mortality ; Osteoarthritis, Knee/physiopathology ; Pain/drug therapy ; Pain/etiology ; Pain/physiopathology ; Pain Measurement ; Patient Satisfaction ; Pyrazoles/economics ; Severity of Illness Index ; Sulfonamides/economics ; Survival Rate ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Celecoxib does not appear to affect prosthesis fixation in total knee replacement: A randomized study using radiostereometry in 50 patients.
Autorzy:
Meunier A; Division of Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Sweden. />Aspenberg P
Good L
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Źródło:
Acta orthopaedica [Acta Orthop] 2009 Feb; Vol. 80 (1), pp. 46-50.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Knee Prosthesis*
Prosthesis Failure*
Anti-Inflammatory Agents, Non-Steroidal/*adverse effects
Arthroplasty, Replacement, Knee/*adverse effects
Cyclooxygenase Inhibitors/*adverse effects
Pyrazoles/*adverse effects
Sulfonamides/*adverse effects
Administration, Oral ; Aged ; Aged, 80 and over ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Bone Density/drug effects ; Bone Remodeling/drug effects ; Celecoxib ; Cyclooxygenase Inhibitors/administration & dosage ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Osteoarthritis, Knee/surgery ; Pyrazoles/administration & dosage ; Risk Factors ; Sulfonamides/administration & dosage ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Reduction in opioid-related adverse events and improvement in function with parecoxib followed by valdecoxib treatment after non-cardiac surgery: a randomized, double-blind, placebo-controlled, parallel-group trial.
Autorzy:
Langford RM; Pain and Anaesthesia Research Group, St Bartholomew's Hospital, West Smithfield, London, EC1A 7BE, UK. />Joshi GP
Gan TJ
Mattera MS
Chen WH
Revicki DA
Chen C
Zlateva G
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Źródło:
Clinical drug investigation [Clin Drug Investig] 2009; Vol. 29 (9), pp. 577-90.
Typ publikacji:
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms:
Analgesics, Opioid/*adverse effects
Cyclooxygenase Inhibitors/*adverse effects
Isoxazoles/*adverse effects
Pain, Postoperative/*drug therapy
Sulfonamides/*adverse effects
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analgesics, Opioid/administration & dosage ; Attitude of Health Personnel ; Cyclooxygenase Inhibitors/administration & dosage ; Double-Blind Method ; Drug Evaluation ; Drug Therapy, Combination ; Elective Surgical Procedures/adverse effects ; Female ; Humans ; Isoxazoles/administration & dosage ; Male ; Middle Aged ; Patient Satisfaction ; Placebos ; Psychometrics/methods ; Sulfonamides/administration & dosage
Czasopismo naukowe
Tytuł:
Effect of non-steroidal anti-inflammatory drugs and the pro-carcinogen 1,2 dimethylhydrazine on the rat intestinal membrane structure and function.
Autorzy:
Mittal N; Department of Biophysics, Panjah University, Chandigarh, India.
Kanwar SS
Sanyal SN
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Źródło:
Nutricion hospitalaria [Nutr Hosp] 2008 Sep-Oct; Vol. 23 (5), pp. 439-48.
Typ publikacji:
Comparative Study; Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
1,2-Dimethylhydrazine/*pharmacology
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Aspirin/*pharmacology
Carcinogens/*pharmacology
Cyclooxygenase Inhibitors/*pharmacology
Intestinal Mucosa/*drug effects
Intestine, Small/*drug effects
Pyrazoles/*pharmacology
Pyridines/*pharmacology
Sulfonamides/*pharmacology
Sulfones/*pharmacology
1,2-Dimethylhydrazine/administration & dosage ; Animal Experimentation ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Aspirin/administration & dosage ; Body Weight ; Carcinogens/administration & dosage ; Celecoxib ; Cyclooxygenase Inhibitors/administration & dosage ; Etoricoxib ; Fluorescence Polarization ; Intestinal Neoplasms/prevention & control ; Intestine, Small/enzymology ; Intestine, Small/metabolism ; Intestine, Small/physiology ; Intestine, Small/ultrastructure ; Male ; Membrane Lipids/metabolism ; Microscopy, Electron, Scanning ; Pyrazoles/administration & dosage ; Pyridines/administration & dosage ; Rats ; Rats, Sprague-Dawley ; Sulfonamides/administration & dosage ; Sulfones/administration & dosage ; Time Factors
Czasopismo naukowe
Tytuł:
COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro.
Autorzy:
Chuang HC; Department of Molecular Microbiology & Immunology, University of Southern California, Los Angeles, USA. />Kardosh A
Gaffney KJ
Petasis NA
Schönthal AH
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Źródło:
Molecular cancer [Mol Cancer] 2008 May 16; Vol. 7, pp. 38. Date of Electronic Publication: 2008 May 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Proliferation/*drug effects
Cyclooxygenase 2/*metabolism
Cyclooxygenase Inhibitors/*pharmacology
Pyrazoles/*pharmacology
Sulfonamides/*pharmacology
Celecoxib ; Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Immunoblotting ; Methylation ; Neoplasms/metabolism ; Neoplasms/pathology ; Pyrazoles/chemistry ; Sulfonamides/chemistry ; Transcription Factor CHOP/metabolism
Czasopismo naukowe
Tytuł:
Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double-blind, randomized, placebo-controlled study.
Autorzy:
Nery FG; Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Monkul ES
Hatch JP
Fonseca M
Zunta-Soares GB
Frey BN
Bowden CL
Soares JC
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Źródło:
Human psychopharmacology [Hum Psychopharmacol] 2008 Mar; Vol. 23 (2), pp. 87-94.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Bipolar Disorder/*drug therapy
Cyclooxygenase Inhibitors/*therapeutic use
Pyrazoles/*therapeutic use
Sulfonamides/*therapeutic use
Adult ; Antimanic Agents/therapeutic use ; Antipsychotic Agents/therapeutic use ; Celecoxib ; Cyclooxygenase Inhibitors/adverse effects ; Double-Blind Method ; Drug Therapy, Combination ; Exanthema/chemically induced ; Female ; Humans ; Male ; Middle Aged ; Psychiatric Status Rating Scales ; Pyrazoles/adverse effects ; Severity of Illness Index ; Sulfonamides/adverse effects ; Time Factors
Czasopismo naukowe
Tytuł:
Renal functional responses to ischaemia-reperfusion injury in normotensive and hypertensive rats following non-selective and selective cyclo-oxygenase inhibition with nitric oxide donation.
Autorzy:
Knight S; Department of Physiology, Aras Windle, University College Cork, Cork, Republic of Ireland.
Johns EJ
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Źródło:
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2008 Jan; Vol. 35 (1), pp. 11-6.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aspirin/*analogs & derivatives
Aspirin/*pharmacology
Cyclooxygenase 2 Inhibitors/*pharmacology
Cyclooxygenase Inhibitors/*pharmacology
Hypertension/*drug therapy
Kidney/*drug effects
Nitrates/*pharmacology
Nitric Oxide Donors/*pharmacology
Pyrazoles/*pharmacology
Reperfusion Injury/*drug therapy
Sulfonamides/*pharmacology
Animals ; Aspirin/therapeutic use ; Blood Pressure/drug effects ; Celecoxib ; Cyclooxygenase 1/metabolism ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/therapeutic use ; Cyclooxygenase Inhibitors/therapeutic use ; Disease Models, Animal ; Diuresis/drug effects ; Glomerular Filtration Rate/drug effects ; Hypertension/metabolism ; Hypertension/physiopathology ; Kidney/blood supply ; Kidney/enzymology ; Kidney/physiopathology ; Male ; Membrane Proteins/metabolism ; Nitrates/therapeutic use ; Nitric Oxide/metabolism ; Nitric Oxide Donors/therapeutic use ; Prostaglandins/metabolism ; Pyrazoles/therapeutic use ; Rats ; Rats, Inbred SHR ; Rats, Wistar ; Renal Circulation/drug effects ; Reperfusion Injury/metabolism ; Reperfusion Injury/physiopathology ; Sodium/urine ; Sulfonamides/therapeutic use ; Time Factors
Czasopismo naukowe
Tytuł:
Inhibition of cyclooxygenase-2 by NS398 attenuates noise-induced hearing loss in mice.
Autorzy:
Sun Y; Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Yu J; Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Lin X; Department of Otolaryngology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322-3030, USA.
Tang W; Department of Otolaryngology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, PR China.
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Źródło:
Scientific reports [Sci Rep] 2016 Mar 03; Vol. 6, pp. 22573. Date of Electronic Publication: 2016 Mar 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cyclooxygenase 2/*biosynthesis
Cyclooxygenase Inhibitors/*pharmacology
Gene Expression Regulation, Enzymologic/*drug effects
Hearing Loss/*drug therapy
Nitrobenzenes/*pharmacology
Noise/*adverse effects
Sulfonamides/*pharmacology
Animals ; Disease Models, Animal ; Female ; Hearing Loss/enzymology ; Hearing Loss/etiology ; Mice ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł:
Celecoxib-cyclodextrin systems: characterization and evaluation of in vitro and in vivo advantage.
Autorzy:
Nagarsenker MS; Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Mumbai 400098, India. mangal_ />Joshi MS
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Źródło:
Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2005 Jan; Vol. 31 (2), pp. 169-78.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cyclooxygenase Inhibitors/*pharmacokinetics
Cyclooxygenase Inhibitors/*pharmacology
Excipients/*chemistry
Pyrazoles/*pharmacokinetics
Pyrazoles/*pharmacology
Sulfonamides/*pharmacokinetics
Sulfonamides/*pharmacology
beta-Cyclodextrins/*chemistry
2-Hydroxypropyl-beta-cyclodextrin ; Administration, Oral ; Animals ; Calorimetry, Differential Scanning ; Celecoxib ; Chemistry, Pharmaceutical ; Cyclooxygenase Inhibitors/administration & dosage ; Pyrazoles/administration & dosage ; Rats ; Rats, Wistar ; Solubility ; Sulfonamides/administration & dosage ; Tablets
Czasopismo naukowe

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